# RGD-PIPELINE: ftp-file-extracts
# MODULE: annotations-version-1.1.9 (Oct 10, 2019)
# GENERATED-ON: 2024/11/16
# PURPOSE: annotations about active Dog objects extracted from RGD database
# ONTOLOGY: ChEBI: ChEBI Ontology
# CONTACT: rgd.data@mcw.edu
# FORMAT: tab delimited text
# NOTES: multiple values in a single column are separated by '|'
#
#COLUMN INFORMATION:
#
#1   RGD_ID	          unique RGD_ID of the annotated object
#2   OBJECT_SYMBOL      official symbol of the annotated object
#3   OBJECT_NAME        official name of the annotated object
#4   OBJECT_TYPE        annotated object data type: one of ['gene','qtl','strain']
#5   TERM_ACC_ID        ontology term accession id
#6   TERM_NAME          ontology term name
#7   QUALIFIER          optional qualifier
#8   EVIDENCE           evidence
#9   WITH               with info
#10  ASPECT             aspect
#11  REFERENCES         db references (Reference RGDID|PUBMED ID)
#12  CREATED_DATE       created date
#13  ASSIGNED_BY        assigned by
#14  MESH_OMIM_ID       MESH:xxx or OMIM:xxx id corresponding to RDO:xxx id found in TERM_ACC_ID column (RGD/CTD Disease Ontology annotations only)
#15  CURATION_NOTES     curation notes provided by RGD curators
#16  ORIGINAL_REFERENCE original reference
RGD_ID	OBJECT_SYMBOL	OBJECT_NAME	OBJECT_TYPE	TERM_ACC_ID	TERM_NAME	QUALIFIER	EVIDENCE	WITH	ASPECT	REFERENCES	CREATED_DATE	ASSIGNED_BY	MESH_OMIM_ID	CURATION_NOTES	ORIGINAL_REFERENCE
12050654	CMTM7	CKLF like MARVEL transmembrane domain containing 7	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CMTM7 mRNA	PMID:22747577
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:16170	mercury(0)	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein	PMID:15590114
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:16170	mercury(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	ABCC1 protein affects the export of and results in decreased susceptibility to Mercury	PMID:15590114
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:16978	leukotriene C4	affects transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D017997	ABCC1 protein affects the transport of Leukotriene C4	PMID:12516967
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:25195	mercury atom	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein	PMID:15590114
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:25195	mercury atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	ABCC1 protein affects the export of and results in decreased susceptibility to Mercury	PMID:15590114
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:28445	vincristine	decreases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D014750	ABCC1 protein results in decreased susceptibility to Vincristine	PMID:12516967
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:31823	mercury dichloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008627	Mercuric Chloride results in increased expression of ABCC1 mRNA; Mercuric Chloride results in increased expression of ABCC1 protein	PMID:15590114
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:31823	mercury dichloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008627	ABCC1 protein affects the export of and results in decreased susceptibility to Mercuric Chloride	PMID:15590114
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:3303	calcein am	affects export	EXP		E	RGD:6480464	20191114	CTD	MESH:C085925	ABCC1 protein affects the export of calcein AM	PMID:12516967
12050846	ABCC1	ATP binding cassette subfamily C member 1	gene	CHEBI:4911	etoposide	decreases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D005047	ABCC1 protein results in decreased susceptibility to Etoposide	PMID:12516967
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:16170	mercury(0)	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein	PMID:15590114
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:16170	mercury(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	ABCC2 protein affects the export of and results in decreased susceptibility to Mercury	PMID:15590114
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:16469	17beta-estradiol	affects transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D004958	ABCC2 protein affects the transport of Estradiol	PMID:15507541
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:16978	leukotriene C4	affects transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D017997	ABCC2 protein affects the transport of Leukotriene C4	PMID:15507541
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:25195	mercury atom	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein	PMID:15590114
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:25195	mercury atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008628	ABCC2 protein affects the export of and results in decreased susceptibility to Mercury	PMID:15590114
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:31823	mercury dichloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008627	Mercuric Chloride results in increased expression of ABCC2 mRNA; Mercuric Chloride results in increased expression of ABCC2 protein	PMID:15590114
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:31823	mercury dichloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008627	ABCC2 protein affects the export of and results in decreased susceptibility to Mercuric Chloride	PMID:15590114
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:63621	saquinavir	affects transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D019258	ABCC2 protein affects the transport of Saquinavir	PMID:12702717
12050879	ABCC2	ATP binding cassette subfamily C member 2	gene	CHEBI:9436	Temocaprilat	affects transport	EXP		E	RGD:6480464	20191114	CTD	MESH:C069156	ABCC2 protein affects the transport of temocaprilat	PMID:15507541
12050914	MAPK9	mitogen-activated protein kinase 9	gene	CHEBI:16240	hydrogen peroxide	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein	PMID:23816505
12050914	MAPK9	mitogen-activated protein kinase 9	gene	CHEBI:16240	hydrogen peroxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]	PMID:23816505
12050914	MAPK9	mitogen-activated protein kinase 9	gene	CHEBI:16856	glutathione	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005978	Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]	PMID:23816505
12050914	MAPK9	mitogen-activated protein kinase 9	gene	CHEBI:26710	sodium chloride	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased phosphorylation of MAPK9 protein	PMID:23816505
12050914	MAPK9	mitogen-activated protein kinase 9	gene	CHEBI:26710	sodium chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]	PMID:23816505
12050914	MAPK9	mitogen-activated protein kinase 9	gene	CHEBI:28939	N-acetyl-L-cysteine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000111	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]	PMID:23816505
12050914	MAPK9	mitogen-activated protein kinase 9	gene	CHEBI:90695	anthra[1,9-cd]pyrazol-6(2H)-one	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C432165	pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]	PMID:23816505
12051364	LOC100686073	metallothionein-1	gene	CHEBI:31823	mercury dichloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008627	Mercuric Chloride results in increased expression of MT1 mRNA	PMID:15590114
12051759	ATG7	autophagy related 7	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of ATG7 mRNA	PMID:27255383
12051818	CA2	carbonic anhydrase 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of CA2 mRNA	PMID:22747577
12052222	SERPINE2	serpin family E member 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of SERPINE2 mRNA	PMID:22747577
12052559	PPARG	peroxisome proliferator activated receptor gamma	gene	CHEBI:17154	nicotinamide	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D009536	Niacinamide results in increased expression of PPARG protein	PMID:22539994
12052559	PPARG	peroxisome proliferator activated receptor gamma	gene	CHEBI:17154	nicotinamide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009536	Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]	PMID:22539994
12052559	PPARG	peroxisome proliferator activated receptor gamma	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]	PMID:22539994
12052585	TJP1	tight junction protein 1	gene	CHEBI:15367	all-trans-retinoic acid	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	Tretinoin results in increased expression of TJP1 mRNA; Tretinoin results in increased expression of TJP1 protein	PMID:17035595
12052585	TJP1	tight junction protein 1	gene	CHEBI:15367	all-trans-retinoic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]	PMID:17035595
12052585	TJP1	tight junction protein 1	gene	CHEBI:60579	calcium oxalate	decreases expression	EXP		E	RGD:6480464	20210907	CTD	MESH:D002129	Calcium Oxalate results in decreased expression of TJP1 protein	PMID:34147488|PMID:36349591
12052585	TJP1	tight junction protein 1	gene	CHEBI:60579	calcium oxalate	multiple interactions	EXP		E	RGD:6480464	20210907	CTD	MESH:D002129	Docetaxel inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]; Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]	PMID:34147488|PMID:36349591
12052585	TJP1	tight junction protein 1	gene	CHEBI:8040	phalloidin	multiple interactions	EXP		E	RGD:6480464	20210907	CTD	MESH:D010590	Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]	PMID:34147488
12053109	CYP1A2	cytochrome P450 family 1 subfamily A member 2	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of CYP1A2 mRNA	PMID:19952500
12053109	CYP1A2	cytochrome P450 family 1 subfamily A member 2	gene	CHEBI:8050	phenacetin	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D010615	CYP1A2 protein affects the metabolism of Phenacetin	PMID:15801540
12053109	CYP1A2	cytochrome P450 family 1 subfamily A member 2	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of CYP1A2 mRNA	PMID:19952500
12053380	AHCY	adenosylhomocysteinase	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of AHCY protein	PMID:19952500
12053380	AHCY	adenosylhomocysteinase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of AHCY protein	PMID:19952500
12053832	EHHADH	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of EHHADH mRNA	PMID:19952500
12054509	EIF5A2	eukaryotic translation initiation factor 5A2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of EIF5A2 mRNA	PMID:22747577
12057161	MMP2	matrix metallopeptidase 2	gene	CHEBI:15379	dioxygen	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D010100	Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein]	PMID:18339021
12057161	MMP2	matrix metallopeptidase 2	gene	CHEBI:17883	hydrogen chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Hydrochloric Acid results in increased expression of MMP2 protein	PMID:18339021
12057161	MMP2	matrix metallopeptidase 2	gene	CHEBI:17883	hydrogen chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein]	PMID:18339021
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:144353	diethyldithiocarbamic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004050	Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]	PMID:8592870
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:17578	toluene	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D014050	CYP2E1 protein affects the metabolism of Toluene	PMID:8592870
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:17578	toluene	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014050	Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]; Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]	PMID:8592870
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:17847	p-cresol	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:C032538	CYP2E1 protein affects the metabolism of 4-cresol	PMID:8592870
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:17987	benzyl alcohol	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D019905	CYP2E1 protein affects the metabolism of Benzyl Alcohol	PMID:8592870
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:28054	o-cresol	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:C034047	CYP2E1 protein affects the metabolism of 2-cresol	PMID:8592870
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of CYP2E1 protein	PMID:19952500
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:5141	fomepizole	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C010238	Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]	PMID:8592870
12058559	CYP2E1	cytochrome P450 family 2 subfamily E member 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of CYP2E1 mRNA	PMID:19952500
12059801	CTSK	cathepsin K	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CTSK mRNA	PMID:22747577
12060061	HGF	hepatocyte growth factor	gene	CHEBI:28748	doxorubicin	decreases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D004317	HGF protein results in decreased susceptibility to Doxorubicin	PMID:15688034
12060417	CPT2	carnitine palmitoyltransferase 2	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of CPT2 mRNA	PMID:19952500
12060747	UGT2B31	UDP-glucuronosyltransferase UGT2B31	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20210119	CTD	MESH:D010634	Phenobarbital results in increased expression of UGT2B4 protein	PMID:19952500
12061939	CAPN1	calpain 1	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of CAPN1 mRNA	PMID:24582689
12061939	CAPN1	calpain 1	gene	CHEBI:9241	spironolactone	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013148	Spironolactone results in decreased expression of CAPN1 protein	PMID:20082611
12062987	MAL2	mal, T cell differentiation protein 2	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of MAL2 mRNA	PMID:27255383
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:16243	quercetin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011794	Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]	PMID:15266218
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28077	rifampicin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D012293	Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein	PMID:22620706
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28411	allicin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C006452	allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]	PMID:15266218
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28445	vincristine	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D014750	ABCB1 protein affects the susceptibility to Vincristine	PMID:24975508
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28445	vincristine	increases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D014750	ABCB1 protein results in increased export of Vincristine	PMID:28093773
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28445	vincristine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014750	valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]	PMID:24975508
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28499	kaempferol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C006552	kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]	PMID:15266218
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28748	doxorubicin	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D004317	ABCB1 protein affects the susceptibility to Doxorubicin	PMID:24975508
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28748	doxorubicin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004317	Doxorubicin results in increased expression of ABCB1 protein	PMID:28093773
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:28748	doxorubicin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004317	valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]	PMID:15492788|PMID:24975508
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:31516	Doramectin	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form results in increased susceptibility to doramectin; ABCB1 mutant form results in increased susceptibility to doramectin	PMID:22834856|PMID:23186803|PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of TTR mRNA]	PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:44658	okadaic acid	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D019319	ABCB1 protein results in increased transport of Okadaic Acid	PMID:24374049
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:45409	ritonavir	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D019438	allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]	PMID:15266218
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:4551	digoxin	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form results in increased susceptibility to Digoxin; ABCB1 mutant form results in increased susceptibility to Digoxin	PMID:16594604|PMID:23186803|PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	[ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]; [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]; MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog]	PMID:20510202|PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:47519	ketoconazole	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D007654	Ketoconazole results in decreased activity of ABCB1 protein	PMID:19754906
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:47519	ketoconazole	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D007654	Ketoconazole results in decreased expression of ABCB1 mRNA	PMID:22620706
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:47519	ketoconazole	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007654	[Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi	PMID:19754906
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:50345	milbemycin	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form results in increased susceptibility to moxidectin; ABCB1 mutant form results in increased susceptibility to moxidectin	PMID:23186803|PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA]	PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:5051	Fexofenadine hydrochloride	decreases uptake	EXP		E	RGD:6480464	20191114	CTD	MESH:C093230	ABCB1 protein results in decreased uptake of fexofenadine	PMID:18299336
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:5831	Hypaconitine	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:C058309	ABCB1 protein results in increased transport of hypaconitine	PMID:23200901
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:5835	hypericin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C004965	hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]	PMID:15266218
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:6078	ivermectin	affects abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 protein affects the abundance of Ivermectin	PMID:20595473
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:6078	ivermectin	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form results in increased susceptibility to Ivermectin; ABCB1 mutant form results in increased susceptibility to Ivermectin; ABCB1 protein mutant form results in increased susceptibility to Ivermectin	PMID:22834856|PMID:22924731|PMID:23186803|PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA]	PMID:25419811
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:6532	loperamide	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D008139	ABCB1 protein affects the susceptibility to Loperamide	PMID:25660379
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:6532	loperamide	increases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D008139	ABCB1 protein results in increased export of Loperamide	PMID:28093773
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:6773	Mesaconitine	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:C019470	ABCB1 protein results in increased transport of mesaconitine	PMID:23200901
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:6916	mexiletine	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D008801	ABCB1 mutant form results in increased susceptibility to Mexiletine	PMID:16594604
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:77733	2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014700	[Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin	PMID:20510202
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:78739	emodepside	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:C468987	ABCB1 protein affects the susceptibility to emodepside	PMID:25660379
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:78761	ML-7	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C070571	[ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]	PMID:20510202
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:8828	rhodamine 123	increases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D020112	ABCB1 protein results in increased export of Rhodamine 123	PMID:28093773
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:8985	SDZ PSC 833	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C070272	valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]	PMID:15492788|PMID:24975508
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:9423	Technetium tc 99m sestamibi	decreases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D017256	ABCB1 gene mutant form results in decreased transport of Technetium Tc 99m Sestamibi	PMID:19754906
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:9423	Technetium tc 99m sestamibi	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D017256	[Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi	PMID:19754906
12063362	ABCB1	ATP binding cassette subfamily B member 1	gene	CHEBI:9948	verapamil	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014700	[Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin	PMID:20510202
12063579	LBX2	ladybird homeobox 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of LBX2 mRNA	PMID:22747577
12064112	OAT	ornithine aminotransferase	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of OAT protein	PMID:32991862
12066106	PPP3CA	protein phosphatase 3 catalytic subunit alpha	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of PPP3CA mRNA	PMID:27255383
12066131	EDN2	endothelin 2	gene	CHEBI:88212	lead(II) chloride	increases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:C029891	lead chloride results in increased secretion of EDN2 protein	PMID:15915659
12067089	SDCBP	syndecan binding protein	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SDCBP mRNA	PMID:27255383
12067598	CP	ceruloplasmin	gene	CHEBI:18248	iron atom	increases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	CP protein results in increased export of Iron	PMID:16806171
12067598	CP	ceruloplasmin	gene	CHEBI:18248	iron atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]	PMID:16806171
12067598	CP	ceruloplasmin	gene	CHEBI:82664	iron(0)	increases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	CP protein results in increased export of Iron	PMID:16806171
12067598	CP	ceruloplasmin	gene	CHEBI:82664	iron(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]	PMID:16806171
12067945	HSPA5	heat shock protein family A (Hsp70) member 5	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of HSPA5 protein	PMID:32991862
12067945	HSPA5	heat shock protein family A (Hsp70) member 5	gene	CHEBI:18320	1,4-dithiothreitol	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004229	Dithiothreitol metabolite results in increased expression of HSPA5 protein	PMID:17416481
12067945	HSPA5	heat shock protein family A (Hsp70) member 5	gene	CHEBI:29699	tunicamycin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014415	Tunicamycin results in increased expression of HSPA5 protein	PMID:17416481
12067945	HSPA5	heat shock protein family A (Hsp70) member 5	gene	CHEBI:42106	L-1,4-dithiothreitol	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004229	Dithiothreitol metabolite results in increased expression of HSPA5 protein	PMID:17416481
12067945	HSPA5	heat shock protein family A (Hsp70) member 5	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of HSPA5 mRNA	PMID:24582689
12067945	HSPA5	heat shock protein family A (Hsp70) member 5	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of HSPA5 protein	PMID:19952500
12067945	HSPA5	heat shock protein family A (Hsp70) member 5	gene	CHEBI:9516	thapsigargin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D019284	Thapsigargin results in increased expression of HSPA5 protein	PMID:17416481
12068442	AKAP12	A-kinase anchoring protein 12	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of AKAP12 mRNA	PMID:27255383
12071595	KCND3	potassium voltage-gated channel subfamily D member 3	gene	CHEBI:17347	testosterone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013739	Testosterone results in increased expression of KCND3 protein	PMID:17054656
12071595	KCND3	potassium voltage-gated channel subfamily D member 3	gene	CHEBI:4784	enalapril	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	Enalapril results in decreased expression of KCND3 mRNA	PMID:19732978
12071640	ADRA1A	adrenoceptor alpha 1A	gene	CHEBI:135929	silodosin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C095285	silodosin binds to and results in decreased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]	PMID:19371927
12071640	ADRA1A	adrenoceptor alpha 1A	gene	CHEBI:8093	phenylephrine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D010656	Phenylephrine binds to and results in increased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]	PMID:19371927
12071790	TRIM54	tripartite motif containing 54	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TRIM54 mRNA	PMID:27255383
12071833	TNPO1	transportin 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of TNPO1 mRNA	PMID:22747577
12072070	MYLK	myosin light chain kinase	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	[ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]	PMID:20510202
12072070	MYLK	myosin light chain kinase	gene	CHEBI:78761	ML-7	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C070571	[ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]	PMID:20510202
12072547	CASP3	caspase 3	gene	CHEBI:15367	all-trans-retinoic acid	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	Tretinoin results in increased activity of CASP3 protein	PMID:16953078
12072547	CASP3	caspase 3	gene	CHEBI:192461	toosendanin	increases cleavage	EXP		E	RGD:6480464	20240604	CTD	MESH:C036454	toosendanin results in increased cleavage of CASP3 protein	PMID:36809669
12072547	CASP3	caspase 3	gene	CHEBI:3441	carvedilol	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C043211	Carvedilol results in decreased activity of CASP3 protein	PMID:12875697
12072547	CASP3	caspase 3	gene	CHEBI:4629	diosgenin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004144	Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein]	PMID:25446497
12072547	CASP3	caspase 3	gene	CHEBI:60579	calcium oxalate	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D002129	Calcium Oxalate results in increased activity of CASP3 protein	PMID:25446497
12072547	CASP3	caspase 3	gene	CHEBI:60579	calcium oxalate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002129	Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein]	PMID:25446497
12072547	CASP3	caspase 3	gene	CHEBI:6538	loratadine	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D017336	Loratadine results in increased activity of CASP3 protein	PMID:20570632
12072547	CASP3	caspase 3	gene	CHEBI:9241	spironolactone	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013148	Spironolactone results in decreased expression of CASP3 protein	PMID:20082611
12072547	CASP3	caspase 3	gene	CHEBI:9453	Terfenadine	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D016593	Terfenadine results in increased activity of CASP3 protein	PMID:20570632
12074068	VIM	vimentin	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of VIM mRNA; ochratoxin A results in increased expression of VIM protein	PMID:33543323
12074068	VIM	vimentin	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of VIM protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]	PMID:33543323
12074886	BCL2	BCL2 apoptosis regulator	gene	CHEBI:17823	calcitriol	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002117	Calcitriol affects the expression of BCL2 protein	PMID:16080513
12074886	BCL2	BCL2 apoptosis regulator	gene	CHEBI:192461	toosendanin	decreases expression	EXP		E	RGD:6480464	20240604	CTD	MESH:C036454	toosendanin results in decreased expression of BCL2 mRNA; toosendanin results in decreased expression of BCL2 protein	PMID:36809669
12074886	BCL2	BCL2 apoptosis regulator	gene	CHEBI:9241	spironolactone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013148	Spironolactone results in increased expression of BCL2 protein	PMID:20082611
12075184	FAS	Fas cell surface death receptor	gene	CHEBI:3441	carvedilol	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C043211	Carvedilol results in decreased expression of FAS	PMID:12875697
12076208	MYPN	myopalladin	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of MYPN mRNA	PMID:27255383
12077453	CCL17	C-C motif chemokine ligand 17	gene	CHEBI:15864	luteolin	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D047311	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL17 promoter	PMID:33763461
12077453	CCL17	C-C motif chemokine ligand 17	gene	CHEBI:69478	cannabidiol	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D002185	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL17 promoter	PMID:33763461
12077464	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	gene	CHEBI:46195	paracetamol	increases glucuronidation	EXP		E	RGD:6480464	20191114	CTD	MESH:D000082	UGT1A6 protein results in increased glucuronidation of Acetaminophen	PMID:11903872
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:17747	bis(2-ethylhexyl) phthalate	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D004051	Diethylhexyl Phthalate results in increased activity of NR1I3 protein	PMID:27732639
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:223316	(+)-artemisinin	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C031327	artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form	PMID:21778469|PMID:27732639
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:223316	(+)-artemisinin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C031327	androstan-3-ol inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]; artemisinin inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]	PMID:21778469
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:24780	imidazoles	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D007093	Imidazoles results in decreased activity of NR1I3 protein alternative form	PMID:21778469
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:24780	imidazoles	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007093	artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]	PMID:21778469
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:35727	triazoles	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D014230	Triazoles results in increased activity of NR1I3 protein alternative form	PMID:21778469
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:3764	clotrimazole	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:D003022	Clotrimazole binds to NR1I3 protein	PMID:21778469
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:3764	clotrimazole	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003022	Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form	PMID:21778469|PMID:27732639
12077895	NR1I3	nuclear receptor subfamily 1 group I member 3	gene	CHEBI:47318	6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein mutant form	PMID:21778469
12079702	IL6	interleukin 6	gene	CHEBI:16412	lipopolysaccharide	increases expression	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	Lipopolysaccharides results in increased expression of IL6 mRNA	PMID:32899721
12079702	IL6	interleukin 6	gene	CHEBI:16412	lipopolysaccharide	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]	PMID:32899721
12079702	IL6	interleukin 6	gene	CHEBI:2682	amphotericin B	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000666	Amphotericin B results in increased expression of IL6 protein	PMID:24105867
12079702	IL6	interleukin 6	gene	CHEBI:2682	amphotericin B	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000666	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]	PMID:24105867
12079702	IL6	interleukin 6	gene	CHEBI:29866	arsenite(3-)	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:C015001	arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]	PMID:32899721
12079702	IL6	interleukin 6	gene	CHEBI:47495	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein	PMID:24105867
12079702	IL6	interleukin 6	gene	CHEBI:47495	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]	PMID:24105867
12079702	IL6	interleukin 6	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of IL6 mRNA	PMID:33543323
12079702	IL6	interleukin 6	gene	CHEBI:7719	ochratoxin A	increases secretion	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased secretion of IL6 protein	PMID:33543323
12080881	NFKBIA	NFKB inhibitor alpha	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	Resveratrol inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]	PMID:21239502
12080881	NFKBIA	NFKB inhibitor alpha	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of NFKBIA mRNA	PMID:22747577
12082040	NT5E	5'-nucleotidase ecto	gene	CHEBI:3441	carvedilol	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C043211	Carvedilol results in increased activity of NT5E protein	PMID:15148268
12083733	HTR2B	5-hydroxytryptamine receptor 2B	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of HTR2B mRNA	PMID:22747577
12085405	B4GALT7	beta-1,4-galactosyltransferase 7	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of B4GALT7 mRNA	PMID:22747577
12085513	LRP8	LDL receptor related protein 8	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of LRP8 mRNA	PMID:22747577
12085621	JAML	junction adhesion molecule like	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of JAML mRNA	PMID:22747577
12085800	MAPK8	mitogen-activated protein kinase 8	gene	CHEBI:16240	hydrogen peroxide	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein	PMID:23816505
12085800	MAPK8	mitogen-activated protein kinase 8	gene	CHEBI:16240	hydrogen peroxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]	PMID:23816505
12085800	MAPK8	mitogen-activated protein kinase 8	gene	CHEBI:16856	glutathione	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005978	Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]	PMID:23816505
12085800	MAPK8	mitogen-activated protein kinase 8	gene	CHEBI:26710	sodium chloride	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased phosphorylation of MAPK8 protein	PMID:23816505
12085800	MAPK8	mitogen-activated protein kinase 8	gene	CHEBI:26710	sodium chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]	PMID:23816505
12085800	MAPK8	mitogen-activated protein kinase 8	gene	CHEBI:28939	N-acetyl-L-cysteine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000111	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]	PMID:23816505
12085800	MAPK8	mitogen-activated protein kinase 8	gene	CHEBI:90695	anthra[1,9-cd]pyrazol-6(2H)-one	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C432165	pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]	PMID:23816505
12085918	LOC478702	tubulin beta-2B chain	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of TUBB2B mRNA	PMID:27255383
12086515	CXCL8	C-X-C motif chemokine ligand 8	gene	CHEBI:15379	dioxygen	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D010100	Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein]	PMID:18339021
12086515	CXCL8	C-X-C motif chemokine ligand 8	gene	CHEBI:17883	hydrogen chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Hydrochloric Acid results in increased expression of CXCL8 protein	PMID:18339021
12086515	CXCL8	C-X-C motif chemokine ligand 8	gene	CHEBI:17883	hydrogen chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein]	PMID:18339021
12086958	EIF3A	eukaryotic translation initiation factor 3 subunit A	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of EIF3A protein	PMID:22747577
12087520	ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein	PMID:18820026
12087520	ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	gene	CHEBI:6904	metoprolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008790	[Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein	PMID:18820026
12087520	ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	gene	CHEBI:87681	ranolazine	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	Ranolazine affects the expression of ATP2A2 protein	PMID:18820026
12087520	ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	gene	CHEBI:87681	ranolazine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein	PMID:18820026
12087575	HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of HNRNPA2B1 protein	PMID:32991862
12087674	EEF2	eukaryotic translation elongation factor 2	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of EEF2 protein	PMID:32991862
12089460	ABCA5	ATP binding cassette subfamily A member 5	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ABCA5 mRNA	PMID:22747577
12090670	DERL2	derlin 2	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of DERL2 mRNA	PMID:27255383
12091856	ESR1	estrogen receptor 1	gene	CHEBI:16469	17beta-estradiol	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004958	Estradiol affects the expression of ESR1 protein	PMID:16483645
12091856	ESR1	estrogen receptor 1	gene	CHEBI:17026	progesterone	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D011374	Progesterone affects the expression of ESR1 protein	PMID:16483645
12093199	ANK1	ankyrin 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of ANK1 mRNA	PMID:27255383
12095224	IMMP2L	inner mitochondrial membrane peptidase subunit 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of IMMP2L mRNA	PMID:22747577
12095504	PRDX6	peroxiredoxin 6	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of PRDX6 protein	PMID:19952500
12095504	PRDX6	peroxiredoxin 6	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of PRDX6 protein	PMID:19952500
12096923	VPS41	VPS41 subunit of HOPS complex	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS41 mRNA	PMID:27255383
12097421	SLCO1B2	solute carrier organic anion transporter family member 1B2	gene	CHEBI:135946	sincalide	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D012844	SLCO1B3 protein results in increased transport of Sincalide	PMID:20079461
12097421	SLCO1B2	solute carrier organic anion transporter family member 1B2	gene	CHEBI:17474	estrone 3-sulfate	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:C017296	SLCO1B3 protein results in increased transport of estrone sulfate	PMID:20079461
12097421	SLCO1B2	solute carrier organic anion transporter family member 1B2	gene	CHEBI:28865	taurocholic acid	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D013656	SLCO1B3 protein results in increased transport of Taurocholic Acid	PMID:20079461
12097421	SLCO1B2	solute carrier organic anion transporter family member 1B2	gene	CHEBI:63836	bromosulfophthalein	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D013448	SLCO1B3 protein results in increased transport of Sulfobromophthalein	PMID:20079461
12097421	SLCO1B2	solute carrier organic anion transporter family member 1B2	gene	CHEBI:73356	DPDPE	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D020881	SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)-	PMID:20079461
12097421	SLCO1B2	solute carrier organic anion transporter family member 1B2	gene	CHEBI:791	17beta-estradiol 17-glucosiduronic acid	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:C025483	SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide	PMID:20079461
12098737	LOC609402	hemoglobin subunit beta-like	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20241001	CTD	MESH:C526575	masitinib results in increased expression of HBG1 mRNA	PMID:22747577
12098749	PXYLP1	2-phosphoxylose phosphatase 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ACPL2 mRNA	PMID:22747577
12099137	ANXA6	annexin A6	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ANXA6 protein	PMID:22747577
12100173	ANXA1	annexin A1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ANXA1 protein	PMID:22747577
12101384	HEBP2	heme binding protein 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of HEBP2 mRNA	PMID:22747577
12101396	DLST	dihydrolipoamide S-succinyltransferase	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of DLST protein	PMID:19952500
12101885	ATG4D	autophagy related 4D cysteine peptidase	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of ATG4D mRNA	PMID:27255383
12101969	CORO1A	coronin 1A	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CORO1A protein	PMID:22747577
12102553	PCM1	pericentriolar material 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PCM1 mRNA	PMID:22747577
12103247	RABEPK	Rab9 effector protein with kelch motifs	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of RABEPK mRNA	PMID:27255383
12104718	PRPS2	phosphoribosyl pyrophosphate synthetase 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of PRPS2 mRNA	PMID:22747577
12105831	SLC18A2	solute carrier family 18 member A2	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC18A2 mRNA]	PMID:25419811
12105831	SLC18A2	solute carrier family 18 member A2	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]	PMID:25419811
12105831	SLC18A2	solute carrier family 18 member A2	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA]	PMID:25419811
12105831	SLC18A2	solute carrier family 18 member A2	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]	PMID:25419811
12106395	AVP	arginine vasopressin	gene	CHEBI:2453	acyclovir	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D000212	Acyclovir results in decreased activity of AVP protein	PMID:2724137
12106395	AVP	arginine vasopressin	gene	CHEBI:41879	dexamethasone	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D003907	Dexamethasone results in decreased expression of AVP protein	PMID:1934541
12107235	CIRBP	cold inducible RNA binding protein	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CIRBP mRNA	PMID:22747577
12107375	SAR1B	secretion associated Ras related GTPase 1B	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20241112	CTD	MESH:C526575	masitinib results in decreased expression of SAR1A mRNA	PMID:22747577
12108225	VPS29	VPS29 retromer complex component	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS29 mRNA	PMID:27255383
12110037	PCK2	phosphoenolpyruvate carboxykinase 2, mitochondrial	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of PCK2 protein	PMID:19952500
12111199	FADD	Fas associated via death domain	gene	CHEBI:132230	marbofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	marbofloxacin results in increased expression of FADD mRNA	PMID:31005593
12111206	IL31	interleukin 31	gene	CHEBI:15864	luteolin	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D047311	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]	PMID:33763461
12111206	IL31	interleukin 31	gene	CHEBI:69478	cannabidiol	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D002185	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]	PMID:33763461
12111640	USO1	USO1 vesicle transport factor	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of USO1 mRNA	PMID:27255383
12112287	TRPV1	transient receptor potential cation channel subfamily V member 1	gene	CHEBI:3374	capsaicin	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D002211	Capsaicin results in increased activity of TRPV1 protein	PMID:17392452
12112287	TRPV1	transient receptor potential cation channel subfamily V member 1	gene	CHEBI:3374	capsaicin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002211	JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]	PMID:17392452
12113038	STX4	syntaxin 4	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of STX4 mRNA	PMID:27255383
12113445	CPS1	carbamoyl-phosphate synthase 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of CPS1 protein	PMID:19952500
12114548	GGT1	gamma-glutamyltransferase 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of GGT1 mRNA	PMID:22747577
12114876	SLC10A4	solute carrier family 10 member 4	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC10A4 mRNA]	PMID:25419811
12114876	SLC10A4	solute carrier family 10 member 4	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA]	PMID:25419811
12114876	SLC10A4	solute carrier family 10 member 4	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA]	PMID:25419811
12114876	SLC10A4	solute carrier family 10 member 4	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]	PMID:25419811
12115416	PSMD6	proteasome 26S subunit, non-ATPase 6	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of PSMD6 protein	PMID:22747577
12116424	CDKN2A	cyclin dependent kinase inhibitor 2A	gene	CHEBI:64090	tert-butyl hydroperoxide	decreases expression	EXP		E	RGD:6480464	20220118	CTD	MESH:D020122	tert-Butylhydroperoxide results in decreased expression of CDKN2A protein	PMID:14729356
12116574	IL18	interleukin 18	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of IL18 mRNA	PMID:33543323
12116574	IL18	interleukin 18	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]	PMID:33543323
12117362	TNFSF11	TNF superfamily member 11	gene	CHEBI:27881	resveratrol	decreases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	Resveratrol results in decreased susceptibility to TNFSF11 protein	PMID:21239502
12117362	TNFSF11	TNF superfamily member 11	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased localization of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased localization of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]	PMID:21239502
12118927	LIN7C	lin-7 homolog C, crumbs cell polarity complex component	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of LIN7C mRNA	PMID:22747577
12119451	TP53	tumor protein p53	gene	CHEBI:192461	toosendanin	increases expression	EXP		E	RGD:6480464	20240604	CTD	MESH:C036454	toosendanin results in increased expression of TP53 mRNA; toosendanin results in increased expression of TP53 protein	PMID:36809669
12119872	POMT1	protein O-mannosyltransferase 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of POMT1 mRNA	PMID:22747577
12120274	CHMP5	charged multivesicular body protein 5	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of CHMP5 mRNA	PMID:27255383
12120555	TRPM8	transient receptor potential cation channel subfamily M member 8	gene	CHEBI:22984	calcium atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]	PMID:16386244
12120555	TRPM8	transient receptor potential cation channel subfamily M member 8	gene	CHEBI:25187	p-menthan-3-ol	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D008610	Menthol results in increased activity of TRPM8 protein	PMID:16386244
12120555	TRPM8	transient receptor potential cation channel subfamily M member 8	gene	CHEBI:25187	p-menthan-3-ol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008610	[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]	PMID:16386244
12120555	TRPM8	transient receptor potential cation channel subfamily M member 8	gene	CHEBI:29320	calcium(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]	PMID:16386244
12120906	TRADD	TNFRSF1A associated via death domain	gene	CHEBI:132230	marbofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	marbofloxacin results in increased expression of TRADD mRNA	PMID:31005593
12120906	TRADD	TNFRSF1A associated via death domain	gene	CHEBI:132230	marbofloxacin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]	PMID:31005593
12120906	TRADD	TNFRSF1A associated via death domain	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of TRADD mRNA	PMID:24582689
12120906	TRADD	TNFRSF1A associated via death domain	gene	CHEBI:7731	ofloxacin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]	PMID:24582689
12121525	TMED1	transmembrane p24 trafficking protein 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TMED1 mRNA	PMID:27255383
12121678	SFT2D2	SFT2 domain containing 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of SFT2D2 mRNA	PMID:22747577
12122857	PGR	progesterone receptor	gene	CHEBI:17026	progesterone	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:D011374	Progesterone binds to PGR protein	PMID:16054490
12122897	TUBG1	tubulin, gamma 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TUBG1 mRNA	PMID:27255383
12123938	KNG1	kininogen 1	gene	CHEBI:16480	nitric oxide	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D009569	Nitric Oxide deficiency results in increased activity of KNG1 protein modified form	PMID:10805402
12123938	KNG1	kininogen 1	gene	CHEBI:25549	nitrites	increases chemical synthesis	EXP		E	RGD:6480464	20191114	CTD	MESH:D009573	KNG1 protein modified form results in increased chemical synthesis of Nitrites	PMID:17644579
12124520	TIMP1	TIMP metallopeptidase inhibitor 1	gene	CHEBI:9241	spironolactone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013148	Spironolactone results in increased expression of TIMP1 protein	PMID:20082611
12125759	CFTR	CF transmembrane conductance regulator	gene	CHEBI:28088	genistein	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D019833	Genistein results in decreased activity of CFTR protein	PMID:15496164
12125759	CFTR	CF transmembrane conductance regulator	gene	CHEBI:34457	5-Nitro-2-(3-phenylpropylamino)benzoic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C058176	5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein	PMID:15496164
12125759	CFTR	CF transmembrane conductance regulator	gene	CHEBI:34795	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D015056	[1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein	PMID:15161604
12125759	CFTR	CF transmembrane conductance regulator	gene	CHEBI:5441	glyburide	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D005905	Glyburide results in decreased activity of CFTR protein	PMID:15496164
12125759	CFTR	CF transmembrane conductance regulator	gene	CHEBI:84612	8-(4-chlorophenylthio)-cAMP	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C015929	[1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein	PMID:15161604
12127651	GXYLT1	glucoside xylosyltransferase 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of GXYLT1 mRNA	PMID:22747577
12130565	PECAM1	platelet and endothelial cell adhesion molecule 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PECAM1 mRNA	PMID:22747577
12130594	EBF3	EBF transcription factor 3	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of EBF3 mRNA]	PMID:25419811
12130594	EBF3	EBF transcription factor 3	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA]	PMID:25419811
12130594	EBF3	EBF transcription factor 3	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA]	PMID:25419811
12130594	EBF3	EBF transcription factor 3	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]	PMID:25419811
12131516	ZNF23	zinc finger protein 23	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ZNF23 mRNA	PMID:22747577
12132159	ELSPBP1	epididymal sperm binding protein 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ELSPBP1 mRNA	PMID:22747577
12132858	TSPAN2	tetraspanin 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TSPAN2 mRNA	PMID:22747577
12133381	SMTN	smoothelin	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of SMTN mRNA	PMID:27255383
12135324	GKN1	gastrokine 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of GKN1 mRNA	PMID:22747577
12135641	EIF4A1	eukaryotic translation initiation factor 4A1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of EIF4A1 protein	PMID:22747577
12136798	PAH	phenylalanine hydroxylase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of PAH protein	PMID:19952500
12136864	TUBA4A	tubulin alpha 4a	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TUBA4A mRNA	PMID:27255383
12136920	ASL	argininosuccinate lyase	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of ASL protein	PMID:19952500
12136920	ASL	argininosuccinate lyase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of ASL protein	PMID:19952500
12137992	CYP26A1	cytochrome P450 family 26 subfamily A member 1	gene	CHEBI:15367	all-trans-retinoic acid	increases degradation	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	CYP26A1 protein results in increased degradation of Tretinoin	PMID:17035595
12137992	CYP26A1	cytochrome P450 family 26 subfamily A member 1	gene	CHEBI:15367	all-trans-retinoic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]	PMID:17035595
12138460	GNAQ	G protein subunit alpha q	gene	CHEBI:61048	ganglioside GM1	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005677	G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]	PMID:21671308
12138460	GNAQ	G protein subunit alpha q	gene	CHEBI:78496	mastoparan	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C037500	G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein	PMID:21671308
12138962	ABCG2	ATP binding cassette subfamily G member 2	gene	CHEBI:10106	zearalenone	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D015025	ABCG2 protein results in increased transport of Zearalenone	PMID:30576553
12138962	ABCG2	ATP binding cassette subfamily G member 2	gene	CHEBI:5831	Hypaconitine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C058309	[3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of hypaconitine	PMID:23200901
12138962	ABCG2	ATP binding cassette subfamily G member 2	gene	CHEBI:6773	Mesaconitine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C019470	[3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of mesaconitine	PMID:23200901
12140683	MGST2	microsomal glutathione S-transferase 2	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of MGST2 mRNA	PMID:19952500
12141041	LYRM1	LYR motif containing 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of LYRM1 mRNA	PMID:22747577
12142365	PYCARD	PYD and CARD domain containing	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of PYCARD mRNA; ochratoxin A results in increased expression of PYCARD protein	PMID:33543323
12142365	PYCARD	PYD and CARD domain containing	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]	PMID:33543323
12142742	STOX1	storkhead box 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of STOX1 mRNA	PMID:22747577
12142850	CD5L	CD5 molecule like	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CD5L mRNA	PMID:22747577
12143356	MICAL1	microtubule associated monooxygenase, calponin and LIM domain containing 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of MICAL1 mRNA	PMID:27255383
12144117	EDEM2	ER degradation enhancing alpha-mannosidase like protein 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of EDEM2 mRNA	PMID:22747577
12144154	SLC9A1	solute carrier family 9 member A1	gene	CHEBI:30621	diarsenic trioxide	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C006632	Arsenic Trioxide results in increased expression of SLC9A1 protein	PMID:23236503
12144154	SLC9A1	solute carrier family 9 member A1	gene	CHEBI:49900	arsenous acid	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C032793	Arsenic Trioxide results in increased expression of SLC9A1 protein	PMID:23236503
12145444	ACAT2	acetyl-CoA acetyltransferase 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ACAT2 mRNA	PMID:22747577
12146852	TTN	titin	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TTN mRNA	PMID:27255383
12147301	CAT	catalase	gene	CHEBI:36560	zinc oxide	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D015034	Zinc Oxide results in decreased activity of CAT protein	PMID:28126643
12151468	PDE6H	phosphodiesterase 6H	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PDE6H mRNA	PMID:22747577
12151708	CYP2D15	cytochrome P450 family 2 subfamily D member 15	gene	CHEBI:34593	Bufuralol	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:C010831	CYP2D6 protein affects the metabolism of bufuralol	PMID:15801540
12151708	CYP2D15	cytochrome P450 family 2 subfamily D member 15	gene	CHEBI:4470	dextromethorphan	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D003915	CYP2D15 affects the metabolism of Dextromethorphan	PMID:7786018
12151708	CYP2D15	cytochrome P450 family 2 subfamily D member 15	gene	CHEBI:47781	desipramine	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D003891	CYP2D15 affects the metabolism of Desipramine	PMID:7786018
12151708	CYP2D15	cytochrome P450 family 2 subfamily D member 15	gene	CHEBI:6904	metoprolol	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D008790	CYP2D15 affects the metabolism of Metoprolol	PMID:7786018
12152101	SLC22A6	solute carrier family 22 member 6	gene	CHEBI:43355	indoxyl sulfate	multiple interactions	EXP		E	RGD:6480464	20230404	CTD	MESH:D007200	[Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican	PMID:36243147
12152101	SLC22A6	solute carrier family 22 member 6	gene	CHEBI:6375	lansoprazole	multiple interactions	EXP		E	RGD:6480464	20230404	CTD	MESH:D064747	[Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican	PMID:36243147
12152101	SLC22A6	solute carrier family 22 member 6	gene	CHEBI:77260	5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole	multiple interactions	EXP		E	RGD:6480464	20230404	CTD	MESH:D009853	[Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican	PMID:36243147
12152101	SLC22A6	solute carrier family 22 member 6	gene	CHEBI:7772	omeprazole	multiple interactions	EXP		E	RGD:6480464	20230404	CTD	MESH:D009853	[Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican	PMID:36243147
12152101	SLC22A6	solute carrier family 22 member 6	gene	CHEBI:7915	pantoprazole	multiple interactions	EXP		E	RGD:6480464	20230404	CTD	MESH:C064276	[Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican	PMID:36243147
12152328	PDHA1	pyruvate dehydrogenase E1 subunit alpha 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of PDHA1 mRNA	PMID:22747577
12154022	PEX19	peroxisomal biogenesis factor 19	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of PEX19 mRNA	PMID:27255383
12154073	LOC479912	glutathione S-transferase Mu 1	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20241112	CTD	MESH:D002994	Clofibrate results in decreased expression of GSTM1 mRNA	PMID:19952500
12154073	LOC479912	glutathione S-transferase Mu 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20241112	CTD	MESH:D010634	Phenobarbital results in decreased expression of GSTM1 mRNA	PMID:19952500
12154650	AP3S1	adaptor related protein complex 3 subunit sigma 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of AP3S1 mRNA	PMID:27255383
12156386	COPB2	COPI coat complex subunit beta 2	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of COPB2 mRNA	PMID:27255383
12157586	ASS1	argininosuccinate synthase 1	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of ASS1 protein	PMID:19952500
12157586	ASS1	argininosuccinate synthase 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of ASS1 protein	PMID:19952500
12158445	IRX6	iroquois homeobox 6	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of IRX6 protein	PMID:22747577
12158997	REN	renin	gene	CHEBI:135026	xibenolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C006027	xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	PMID:6103674
12158997	REN	renin	gene	CHEBI:145568	cilazapril monohydrate	increases activity	EXP		E	RGD:6480464	20200107	CTD	MESH:D017315	Cilazapril results in increased activity of REN protein	PMID:2419701
12158997	REN	renin	gene	CHEBI:15551	prostaglandin E2	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015232	Dinoprostone results in increased expression of REN protein	PMID:495730
12158997	REN	renin	gene	CHEBI:18357	(R)-noradrenaline	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	Norepinephrine results in increased activity of REN protein	PMID:8952593
12158997	REN	renin	gene	CHEBI:2668	amlodipine	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D017311	Amlodipine results in increased expression of REN protein	PMID:10218729
12158997	REN	renin	gene	CHEBI:2682	amphotericin B	decreases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:D000666	Amphotericin B results in decreased secretion of REN protein	PMID:7391978
12158997	REN	renin	gene	CHEBI:28787	nitroglycerin	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D005996	Nitroglycerin results in decreased activity of REN protein	PMID:8640982
12158997	REN	renin	gene	CHEBI:2904	atenolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D001262	Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	PMID:6103674
12158997	REN	renin	gene	CHEBI:35457	EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D000806	Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein	PMID:6257882
12158997	REN	renin	gene	CHEBI:35457	EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor	increases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:D000806	Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein	PMID:6185789
12158997	REN	renin	gene	CHEBI:3757	clonidine (imino form)	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in decreased activity of REN protein	PMID:6991409
12158997	REN	renin	gene	CHEBI:3757	clonidine (imino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in decreased secretion of and results in decreased activity of REN protein	PMID:6248808
12158997	REN	renin	gene	CHEBI:46631	clonidine	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in decreased activity of REN protein	PMID:6991409
12158997	REN	renin	gene	CHEBI:46631	clonidine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in decreased secretion of and results in decreased activity of REN protein	PMID:6248808
12158997	REN	renin	gene	CHEBI:46632	clonidine (amino form)	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in decreased activity of REN protein	PMID:6991409
12158997	REN	renin	gene	CHEBI:46632	clonidine (amino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in decreased secretion of and results in decreased activity of REN protein	PMID:6248808
12158997	REN	renin	gene	CHEBI:472805	ouabain	decreases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:D010042	Ouabain results in decreased secretion of REN protein	PMID:6093556
12158997	REN	renin	gene	CHEBI:472805	ouabain	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D010042	Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]	PMID:6093556
12158997	REN	renin	gene	CHEBI:4784	enalapril	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	Enalapril results in increased activity of REN protein	PMID:12019275
12158997	REN	renin	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	[Enalapril co-treated with FR 173657] results in increased activity of REN protein	PMID:12019275
12158997	REN	renin	gene	CHEBI:64317	isoprenaline	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D007545	Isoproterenol results in increased activity of REN protein	PMID:6103674
12158997	REN	renin	gene	CHEBI:64317	isoprenaline	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007545	Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	PMID:6103674
12158997	REN	renin	gene	CHEBI:6541	losartan	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D019808	Losartan results in increased expression of REN protein	PMID:10483973
12158997	REN	renin	gene	CHEBI:74125	losartan carboxylic acid	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C066026	losartan carboxylic acid results in increased expression of REN protein	PMID:10483973
12158997	REN	renin	gene	CHEBI:7596	nitroprusside	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D009599	Nitroprusside results in increased activity of REN protein	PMID:2434793|PMID:6399253
12158997	REN	renin	gene	CHEBI:7983	pentobarbital	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D010424	Pentobarbital results in increased activity of REN protein	PMID:6348358
12158997	REN	renin	gene	CHEBI:8093	phenylephrine	increases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:D010656	Phenylephrine results in increased secretion of REN protein	PMID:6347479
12158997	REN	renin	gene	CHEBI:8214	pindolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D010869	Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	PMID:6103674
12158997	REN	renin	gene	CHEBI:8499	propranolol	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D011433	Propranolol results in decreased activity of REN protein	PMID:2566282
12158997	REN	renin	gene	CHEBI:8499	propranolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011433	Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]	PMID:6103674
12158997	REN	renin	gene	CHEBI:8862	Rilmenidine	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C032302	Rilmenidine results in decreased activity of REN protein	PMID:2866274
12160227	RPS6KB1	ribosomal protein S6 kinase B1	gene	CHEBI:9753	troglitazone	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C057693	Troglitazone results in decreased activity of and results in decreased phosphorylation of RPS6KB1 protein	PMID:16825603
12162018	NOS2	nitric oxide synthase 2	gene	CHEBI:17883	hydrogen chloride	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Hydrochloric Acid results in increased activity of NOS2 protein	PMID:14621274
12162819	VPS16	VPS16 core subunit of CORVET and HOPS complexes	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS16 mRNA	PMID:27255383
12164689	NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of NDUFS1 mRNA	PMID:22747577
12164984	SPP1	secreted phosphoprotein 1	gene	CHEBI:17833	gentamycin	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:D005839	Gentamicins results in increased expression of SPP1 protein	PMID:33290828
12166457	FTCD	formimidoyltransferase cyclodeaminase	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of FTCD protein	PMID:19952500
12167375	ALAS2	5'-aminolevulinate synthase 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ALAS2 mRNA	PMID:22747577
12167898	SELENBP1	selenium binding protein 1	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of SELENBP1 protein	PMID:19952500
12167898	SELENBP1	selenium binding protein 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of SELENBP1 protein	PMID:22747577
12167898	SELENBP1	selenium binding protein 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of SELENBP1 protein	PMID:19952500
12169167	DDIT3	DNA damage inducible transcript 3	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of DDIT3 mRNA	PMID:24582689
12169872	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	gene	CHEBI:6931	midazolam	affects metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D008874	CYP3A4 protein affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam	PMID:15801540
12169872	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of CYP3A4 mRNA	PMID:19952500
12169889	CPNE6	copine 6	gene	CHEBI:15342	acenaphthoquinone	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C023722	DHRS4 protein results in increased reduction of acenaphthenequinone	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:16243	quercetin	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D011794	Quercetin results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:16325	lithocholic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D008095	Lithocholic Acid results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:17639	3-oxo-5beta-cholanic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C046230	3-oxocholan-24-oic acid results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:18280	phenylglyoxylic acid	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C012482	DHRS4 protein results in increased reduction of phenylglyoxylic acid	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:27539	isatin	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:D007510	DHRS4 protein results in increased reduction of Isatin	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:28088	genistein	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D019833	Genistein results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:28499	kaempferol	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C006552	kaempferol results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:28869	menadione	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:D024483	DHRS4 protein results in increased reduction of Vitamin K 3	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:28875	tetradecanoic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D019814	Myristic Acid results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:34166	16-Ketoestrone	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C002591	DHRS4 protein results in increased reduction of 16-ketoestrone	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:36237	cholanic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C007036	cholanic acid results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:36812	valerophenone	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C547345	DHRS4 protein results in increased reduction of valerophenone	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:37454	9,10-phenanthroquinone	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C005399	DHRS4 protein results in increased reduction of 9,10-phenanthrenequinone	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:39867	valproic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D014635	Valproic Acid results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:42638	flufenamic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D005439	Flufenamic Acid results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:52774	pentane-2,3-dione	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C013186	DHRS4 protein results in increased reduction of 2,3-pentanedione	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of DHRS4 mRNA	PMID:22747577
12169889	CPNE6	copine 6	gene	CHEBI:63836	bromosulfophthalein	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D013448	Sulfobromophthalein results in decreased activity of DHRS4 protein	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:78273	9-cis-retinal	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C031390	DHRS4 protein results in increased reduction of 9-cis-retinal	PMID:17827741
12169889	CPNE6	copine 6	gene	CHEBI:87583	hexane-2,3-dione	increases reduction	EXP		E	RGD:6480464	20191114	CTD	MESH:C043231	DHRS4 protein results in increased reduction of 2,3-hexanedione	PMID:17827741
12170359	CNR2	cannabinoid receptor 2	gene	CHEBI:135574	nabilone	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:C011941	nabilone binds to CNR2 protein	PMID:21871882
12170359	CNR2	cannabinoid receptor 2	gene	CHEBI:146245	SR 144528	multiple interactions	EXP		E	RGD:6480464	20200407	CTD	MESH:C110630	SR 144528 binds to and results in decreased activity of CNR2 protein	PMID:21871882
12170359	CNR2	cannabinoid receptor 2	gene	CHEBI:73295	WIN 55212-2	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:C070417	(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone binds to CNR2 protein	PMID:21871882
12171830	PPA1	inorganic pyrophosphatase 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of PPA1 protein	PMID:22747577
12172571	PRKACB	protein kinase cAMP-activated catalytic subunit beta	gene	CHEBI:2682	amphotericin B	increases expression	EXP		E	RGD:6480464	20241015	CTD	MESH:D000666	Amphotericin B results in increased expression of PRKACG protein	PMID:24105867
12172571	PRKACB	protein kinase cAMP-activated catalytic subunit beta	gene	CHEBI:2682	amphotericin B	multiple interactions	EXP		E	RGD:6480464	20241015	CTD	MESH:D000666	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein]	PMID:24105867
12172571	PRKACB	protein kinase cAMP-activated catalytic subunit beta	gene	CHEBI:47495	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide	multiple interactions	EXP		E	RGD:6480464	20241015	CTD	MESH:C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein]	PMID:24105867
12173937	GSTO1	glutathione S-transferase omega 1	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of GSTO1 mRNA	PMID:19952500
12173937	GSTO1	glutathione S-transferase omega 1	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of GSTO1 mRNA	PMID:19952500
12175766	NTRK1	neurotrophic receptor tyrosine kinase 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of NTRK1 mRNA	PMID:22747577
12176018	MYOZ1	myozenin 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of MYOZ1 mRNA	PMID:22747577
12176711	CLU	clusterin	gene	CHEBI:17833	gentamycin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D005839	Gentamicins results in increased expression of CLU mRNA; Gentamicins results in increased expression of CLU protein	PMID:25034533|PMID:33290828
12178044	AHR	aryl hydrocarbon receptor	gene	CHEBI:28119	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013749	[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein	PMID:24389113
12178044	AHR	aryl hydrocarbon receptor	gene	CHEBI:28909	iprodione	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C033148	[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein	PMID:24389113
12178044	AHR	aryl hydrocarbon receptor	gene	CHEBI:32114	salicylamide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C031060	[salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin	PMID:24389113
12178044	AHR	aryl hydrocarbon receptor	gene	CHEBI:63933	Aroclor 1254	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D020111	[Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein	PMID:24389113
12178044	AHR	aryl hydrocarbon receptor	gene	CHEBI:8434	prochloraz	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C045362	[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz	PMID:24389113
12179802	CYCS	cytochrome c, somatic	gene	CHEBI:192461	toosendanin	multiple interactions	EXP		E	RGD:6480464	20240604	CTD	MESH:C036454	toosendanin results in increased expression of and affects the localization of CYCS protein	PMID:36809669
12180515	CYP2A13	cytochrome P450 family 2 subfamily A polypeptide 13	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of CYP2A13 mRNA	PMID:19952500
12180515	CYP2A13	cytochrome P450 family 2 subfamily A polypeptide 13	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of CYP2A13 mRNA	PMID:19952500
12181438	ASCC1	activating signal cointegrator 1 complex subunit 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ASCC1 mRNA	PMID:22747577
12182321	CLDN1	claudin 1	gene	CHEBI:15367	all-trans-retinoic acid	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	Tretinoin results in increased expression of CLDN1 mRNA; Tretinoin results in increased expression of CLDN1 protein	PMID:17035595
12182321	CLDN1	claudin 1	gene	CHEBI:15367	all-trans-retinoic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]	PMID:17035595
12182644	LOC475707	GPN-loop GTPase 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of GPN1 mRNA	PMID:22747577
12184043	CYP2C41	cytochrome P450 2C41	gene	CHEBI:17578	toluene	affects metabolic processing	EXP		E	RGD:6480464	20231128	CTD	MESH:D014050	CYP2C11 protein affects the metabolism of Toluene	PMID:8592870
12184043	CYP2C41	cytochrome P450 2C41	gene	CHEBI:17847	p-cresol	affects metabolic processing	EXP		E	RGD:6480464	20231128	CTD	MESH:C032538	CYP2C11 protein affects the metabolism of 4-cresol	PMID:8592870
12184043	CYP2C41	cytochrome P450 2C41	gene	CHEBI:17987	benzyl alcohol	affects metabolic processing	EXP		E	RGD:6480464	20231128	CTD	MESH:D019905	CYP2C11 protein affects the metabolism of Benzyl Alcohol	PMID:8592870
12184043	CYP2C41	cytochrome P450 2C41	gene	CHEBI:47381	diclofenac	affects metabolic processing	EXP		E	RGD:6480464	20220412	CTD	MESH:D004008	CYP2C9 protein affects the metabolism of Diclofenac	PMID:15801540
12184043	CYP2C41	cytochrome P450 2C41	gene	CHEBI:47381	diclofenac	increases hydroxylation	EXP		E	RGD:6480464	20241112	CTD	MESH:D004008	CYP2C19 protein results in increased hydroxylation of Diclofenac	PMID:15677349
12184043	CYP2C41	cytochrome P450 2C41	gene	CHEBI:49575	diazepam	affects metabolic processing	EXP		E	RGD:6480464	20241112	CTD	MESH:D003975	CYP2C19 protein affects the metabolism of Diazepam	PMID:15801540
12184558	ACSM3	acyl-CoA synthetase medium chain family member 3	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ACSM3 mRNA	PMID:22747577
12185148	SEC24D	SEC24 homolog D, COPII coat complex component	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SEC24D mRNA	PMID:27255383
12185184	ATP6V0D1	ATPase H+ transporting V0 subunit d1	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of ATP6V0D1 protein	PMID:32991862
12185421	ACHE	acetylcholinesterase	gene	CHEBI:136185	VX nerve agent	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C009680	VX results in decreased activity of ACHE protein	PMID:16915560
12185421	ACHE	acetylcholinesterase	gene	CHEBI:136185	VX nerve agent	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C009680	[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]	PMID:16915560
12185421	ACHE	acetylcholinesterase	gene	CHEBI:16684	atropine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D001285	[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]	PMID:16915560
12185421	ACHE	acetylcholinesterase	gene	CHEBI:34690	dichlorvos	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D004006	Dichlorvos results in decreased activity of ACHE protein	PMID:3627083|PMID:89824
12185421	ACHE	acetylcholinesterase	gene	CHEBI:75701	sarin	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D012524	Sarin results in decreased activity of ACHE protein	PMID:16915560
12185421	ACHE	acetylcholinesterase	gene	CHEBI:75701	sarin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012524	[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]	PMID:16915560
12185421	ACHE	acetylcholinesterase	gene	CHEBI:78734	tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D001285	[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]	PMID:16915560
12185421	ACHE	acetylcholinesterase	gene	CHEBI:9195	Soman	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D012999	Soman results in decreased activity of ACHE protein	PMID:16915560
12185421	ACHE	acetylcholinesterase	gene	CHEBI:9195	Soman	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012999	[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]	PMID:16915560
12185534	CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20241112	CTD	MESH:D002994	Clofibrate results in increased expression of CYP4A11 mRNA	PMID:19952500
12185534	CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20241112	CTD	MESH:D010634	Phenobarbital results in decreased expression of CYP4A11 mRNA	PMID:19952500
12185593	TEAD4	TEA domain transcription factor 4	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TEAD4 mRNA	PMID:22747577
12187213	SLC2A9	solute carrier family 2 member 9	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D014527	SLC2A9 protein results in increased transport of Uric Acid	PMID:18989453
12187275	CASK	calcium/calmodulin dependent serine protein kinase	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of CASK mRNA	PMID:27255383
12187382	MDH2	malate dehydrogenase 2	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of MDH2 protein	PMID:32991862
12187832	ACE	angiotensin I converting enzyme	gene	CHEBI:177391	Ceronapril	decreases activity	EXP		E	RGD:6480464	20210907	CTD	MESH:C054518	ceronapril results in decreased activity of ACE protein	PMID:1812274
12188501	NOX4	NADPH oxidase 4	gene	CHEBI:32020	pitavastatin	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in decreased expression of NOX4 mRNA	PMID:15502390
12188501	NOX4	NADPH oxidase 4	gene	CHEBI:71260	pitavastatin(1-)	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in decreased expression of NOX4 mRNA	PMID:15502390
12188532	ADRA2A	adrenoceptor alpha 2A	gene	CHEBI:3757	clonidine (imino form)	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	ADRA2A protein results in increased susceptibility to Clonidine	PMID:16814767
12188532	ADRA2A	adrenoceptor alpha 2A	gene	CHEBI:3757	clonidine (imino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine binds to and results in increased activity of ADRA2A protein	PMID:16814767
12188532	ADRA2A	adrenoceptor alpha 2A	gene	CHEBI:46631	clonidine	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	ADRA2A protein results in increased susceptibility to Clonidine	PMID:16814767
12188532	ADRA2A	adrenoceptor alpha 2A	gene	CHEBI:46631	clonidine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine binds to and results in increased activity of ADRA2A protein	PMID:16814767
12188532	ADRA2A	adrenoceptor alpha 2A	gene	CHEBI:46632	clonidine (amino form)	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	ADRA2A protein results in increased susceptibility to Clonidine	PMID:16814767
12188532	ADRA2A	adrenoceptor alpha 2A	gene	CHEBI:46632	clonidine (amino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine binds to and results in increased activity of ADRA2A protein	PMID:16814767
12188915	ACTR2	actin related protein 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ACTR2 protein	PMID:22747577
12189900	PDIA3	protein disulfide isomerase family A member 3	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PDIA3 protein	PMID:22747577
12189900	PDIA3	protein disulfide isomerase family A member 3	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of PDIA3 protein	PMID:19952500
12190112	KCNJ2	potassium inwardly rectifying channel subfamily J member 2	gene	CHEBI:17347	testosterone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013739	Testosterone results in increased expression of KCNJ2 protein	PMID:17054656
12190768	RAB31	RAB31, member RAS oncogene family	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of RAB31 mRNA	PMID:27255383
12190790	WT1	WT1 transcription factor	gene	CHEBI:16480	nitric oxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009569	[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA	PMID:21443142
12190790	WT1	WT1 transcription factor	gene	CHEBI:7596	nitroprusside	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009599	[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA	PMID:21443142
12192059	IL1B	interleukin 1 beta	gene	CHEBI:16412	lipopolysaccharide	increases expression	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	Lipopolysaccharides results in increased expression of IL1B mRNA	PMID:32899721
12192059	IL1B	interleukin 1 beta	gene	CHEBI:16412	lipopolysaccharide	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]	PMID:32899721
12192059	IL1B	interleukin 1 beta	gene	CHEBI:29866	arsenite(3-)	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:C015001	arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]	PMID:32899721
12192059	IL1B	interleukin 1 beta	gene	CHEBI:44445	nimesulide	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C012655	nimesulide results in decreased expression of IL1B mRNA	PMID:19638440
12192059	IL1B	interleukin 1 beta	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B protein	PMID:33543323
12192059	IL1B	interleukin 1 beta	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]	PMID:33543323
12192158	VPS33B	VPS33B late endosome and lysosome associated	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS33B mRNA	PMID:27255383
12192371	ALPI	alkaline phosphatase, intestinal	gene	CHEBI:17263	estrone	increases chemical synthesis	EXP		E	RGD:6480464	20191114	CTD	MESH:D004970	ALPI protein results in increased chemical synthesis of Estrone	PMID:1495895
12192371	ALPI	alkaline phosphatase, intestinal	gene	CHEBI:17440	4-nitrophenyl phosphate	increases chemical synthesis	EXP		E	RGD:6480464	20191114	CTD	MESH:C008644	ALPI protein results in increased chemical synthesis of nitrophenylphosphate	PMID:1495895
12192371	ALPI	alkaline phosphatase, intestinal	gene	CHEBI:27632	acetophenone	increases chemical synthesis	EXP		E	RGD:6480464	20191114	CTD	MESH:C038699	ALPI protein results in increased chemical synthesis of acetophenone	PMID:1495895
12194335	MGMT	O-6-methylguanine-DNA methyltransferase	gene	CHEBI:3423	carmustine	decreases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D002330	MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine	PMID:15053863
12194335	MGMT	O-6-methylguanine-DNA methyltransferase	gene	CHEBI:3423	carmustine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002330	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	PMID:14617759
12195592	SAE1	SUMO1 activating enzyme subunit 1	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of SAE1 protein	PMID:32991862
12195612	EBPL	EBP like	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of EBPL mRNA	PMID:22747577
12196334	STX16	syntaxin 16	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of STX16 mRNA	PMID:22747577
12197733	ARF4	ADP ribosylation factor 4	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of ARF4 mRNA	PMID:27255383
12197785	RYR2	ryanodine receptor 2	gene	CHEBI:3441	carvedilol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C043211	Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein	PMID:17448375
12198974	NAPG	NSF attachment protein gamma	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of NAPG mRNA	PMID:22747577
12199021	APP	amyloid beta precursor protein	gene	CHEBI:28694	copper atom	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D003300	Copper results in increased expression of APP protein	PMID:16886094
12199021	APP	amyloid beta precursor protein	gene	CHEBI:30052	copper(0)	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D003300	Copper results in increased expression of APP protein	PMID:16886094
12199089	LOC474850	heat shock 70 kDa protein 1-like	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of HSPA1L mRNA	PMID:22747577
12199883	PSMD9	proteasome 26S subunit, non-ATPase 9	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of PSMD9 mRNA	PMID:22747577
12201020	CPNE1	copine 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CPNE1 mRNA	PMID:22747577
12201171	FGFR2	fibroblast growth factor receptor 2	gene	CHEBI:17883	hydrogen chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Hydrochloric Acid results in increased expression of FGFR2 mRNA	PMID:15883737
12203515	TMEM108	transmembrane protein 108	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TMEM108 mRNA	PMID:22747577
12203958	MGST1	microsomal glutathione S-transferase 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of MGST1 mRNA	PMID:19952500
12203958	MGST1	microsomal glutathione S-transferase 1	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of MGST1 mRNA	PMID:19952500
12204155	SPTBN1	spectrin beta, non-erythrocytic 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SPTBN1 mRNA	PMID:27255383
12205516	ITGA6	integrin subunit alpha 6	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ITGA6 mRNA	PMID:22747577
12205685	ATP5F1B	ATP synthase F1 subunit beta	gene	CHEBI:17883	hydrogen chloride	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Hydrochloric Acid results in decreased expression of ATP5F1B mRNA	PMID:15883737
12205685	ATP5F1B	ATP synthase F1 subunit beta	gene	CHEBI:17883	hydrogen chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	[Hydrochloric Acid co-treated with Bile Acids and Salts] results in decreased expression of ATP5F1B mRNA	PMID:15883737
12206121	PLCG1	phospholipase C gamma 1	gene	CHEBI:60427	dioleoyl phosphatidic acid	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C037657	dioleoylphosphatidic acid results in increased activity of PLCG1 protein	PMID:2001791
12206121	PLCG1	phospholipase C gamma 1	gene	CHEBI:62085	dimyristoyl phosphatidic acid	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C025602	dimyristoylphosphatidic acid results in increased activity of PLCG1 protein	PMID:2001791
12206121	PLCG1	phospholipase C gamma 1	gene	CHEBI:72999	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D015060	1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein	PMID:2001791
12206121	PLCG1	phospholipase C gamma 1	gene	CHEBI:72999	1,2-dihexadecanoyl-sn-glycero-3-phosphocholine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D015060	dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]	PMID:2001791
12206121	PLCG1	phospholipase C gamma 1	gene	CHEBI:78105	dihexadecanoyl phosphatidic acid	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C031599	dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein	PMID:2001791
12206121	PLCG1	phospholipase C gamma 1	gene	CHEBI:78105	dihexadecanoyl phosphatidic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C031599	dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]	PMID:2001791
12206121	PLCG1	phospholipase C gamma 1	gene	CHEBI:84165	1-stearoyl-2-arachidonoylphosphatidic acid	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C060203	1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein	PMID:2001791
12206702	ANP32E	acidic nuclear phosphoprotein 32 family member E	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ANP32E mRNA	PMID:22747577
12206766	TNNT2	troponin T2, cardiac type	gene	CHEBI:28748	doxorubicin	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004317	Doxorubicin affects the expression of TNNT2 protein	PMID:12322705
12206884	COPB1	COPI coat complex subunit beta 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of COPB1 mRNA	PMID:27255383
12206910	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of DNAJC3 protein	PMID:32991862
12207057	HIF1A	hypoxia inducible factor 1 subunit alpha	gene	CHEBI:34159	15-deoxy-Delta(12,14)-prostaglandin J2	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C097240	15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein	PMID:17658243
12207336	SCD	stearoyl-CoA desaturase	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of SCD mRNA	PMID:22747577
12207969	ADPRH	ADP-ribosylarginine hydrolase	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ADPRH mRNA	PMID:22747577
12208058	GSTK1	glutathione S-transferase kappa 1	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of GSTK1 mRNA	PMID:19952500
12208319	LOC486353	SEC14-like protein 4	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of SEC14L4 protein	PMID:19952500
12209006	IMMT	inner membrane mitochondrial protein	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of IMMT protein	PMID:32991862
12209509	GPT	glutamic--pyruvic transaminase	gene	CHEBI:9728	trimethaphan	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014294	Trimethaphan results in increased expression of GPT protein	PMID:6848019
12209713	NSG1	neuronal vesicle trafficking associated 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of NSG1 mRNA	PMID:22747577
12210134	SCN10A	sodium voltage-gated channel alpha subunit 10	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SCN10A mRNA	PMID:27255383
12210611	LCN2	lipocalin 2	gene	CHEBI:17833	gentamycin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D005839	Gentamicins results in increased expression of LCN2 mRNA; Gentamicins results in increased expression of LCN2 protein	PMID:25034533|PMID:33290828
12212542	TSHB	thyroid stimulating hormone subunit beta	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TSHB mRNA	PMID:22747577
12212878	VTI1B	vesicle transport through interaction with t-SNAREs 1B	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VTI1B mRNA	PMID:27255383
12213188	GABRQ	gamma-aminobutyric acid type A receptor subunit theta	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GABRQ mRNA]	PMID:25419811
12213188	GABRQ	gamma-aminobutyric acid type A receptor subunit theta	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA]	PMID:25419811
12213188	GABRQ	gamma-aminobutyric acid type A receptor subunit theta	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA]	PMID:25419811
12213188	GABRQ	gamma-aminobutyric acid type A receptor subunit theta	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]	PMID:25419811
12213368	CDKN1A	cyclin dependent kinase inhibitor 1A	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CDKN1A mRNA	PMID:22747577
12213379	AGA	aspartylglucosaminidase	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of AGA mRNA	PMID:22747577
12213672	CLTCL1	clathrin heavy chain like 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of CLTCL1 mRNA	PMID:27255383
12213926	SIRT1	sirtuin 1	gene	CHEBI:17154	nicotinamide	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D009536	Niacinamide results in decreased expression of SIRT1 protein	PMID:22539994
12213926	SIRT1	sirtuin 1	gene	CHEBI:17154	nicotinamide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009536	Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]	PMID:22539994
12213926	SIRT1	sirtuin 1	gene	CHEBI:27881	resveratrol	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	Resveratrol results in increased activity of SIRT1 protein	PMID:22539994
12213926	SIRT1	sirtuin 1	gene	CHEBI:27881	resveratrol	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	Resveratrol results in increased expression of SIRT1 protein	PMID:21239502|PMID:22539994
12213926	SIRT1	sirtuin 1	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	[[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein; [Resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of SIRT1 protein]; Resveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein]; SIRT1 protein affects the reaction [Resveratrol results in decreased acetylation of RUNX2 protein]	PMID:21239502|PMID:22539994
12215478	SELP	selectin P	gene	CHEBI:31530	edaravone	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C005435	Edaravone results in decreased expression of SELP protein	PMID:16041266
12215478	SELP	selectin P	gene	CHEBI:9574	Thrombin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013917	Thrombin results in increased expression of SELP	PMID:21034320
12215829	GPAA1	glycosylphosphatidylinositol anchor attachment 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of GPAA1 mRNA	PMID:27255383
12221388	MOB1B	MOB kinase activator 1B	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of MOB1B mRNA	PMID:22747577
12221655	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of YWHAZ protein	PMID:22747577
12224500	CYP2C18	cytochrome P450 2C21	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of CYP2C18 mRNA	PMID:19952500
12224854	GSR	glutathione-disulfide reductase	gene	CHEBI:29678	sodium arsenite	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C017947	sodium arsenite results in decreased activity of GSR protein	PMID:18163546
12224854	GSR	glutathione-disulfide reductase	gene	CHEBI:29678	sodium arsenite	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C017947	[monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]	PMID:18163546
12224854	GSR	glutathione-disulfide reductase	gene	CHEBI:63623	succimer	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004113	[monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]	PMID:18163546
12225383	RGS13	regulator of G protein signaling 13	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of RGS13 mRNA	PMID:22747577
12225830	DAO	D-amino acid oxidase	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of DAO mRNA]	PMID:25419811
12225830	DAO	D-amino acid oxidase	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA]	PMID:25419811
12225830	DAO	D-amino acid oxidase	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA]	PMID:25419811
12225830	DAO	D-amino acid oxidase	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]	PMID:25419811
12226040	VPS54	VPS54 subunit of GARP complex	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of VPS54 mRNA	PMID:27255383
12226319	SYTL1	synaptotagmin like 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SYTL1 mRNA	PMID:27255383
12227151	KIF5B	kinesin family member 5B	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of KIF5B mRNA	PMID:27255383
12228288	MAPK14	mitogen-activated protein kinase 14	gene	CHEBI:15355	acetylcholine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000109	Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein	PMID:9688607
12228338	CCT2	chaperonin containing TCP1 subunit 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of CCT2 protein	PMID:22747577
12228377	UROC1	urocanate hydratase 1	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of UROC1 protein	PMID:19952500
12228377	UROC1	urocanate hydratase 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of UROC1 protein	PMID:19952500
12228928	SCAMP3	secretory carrier membrane protein 3	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of SCAMP3 mRNA	PMID:27255383
12230130	RAB11A	RAB11A, member RAS oncogene family	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of RAB11A protein	PMID:32991862
12230450	KRT1	keratin 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of KRT1 protein	PMID:19952500
12230481	PSMB9	proteasome 20S subunit beta 9	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PSMB9 mRNA	PMID:22747577
12234055	NAB1	NGFI-A binding protein 1	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein	PMID:18820026
12234055	NAB1	NGFI-A binding protein 1	gene	CHEBI:6904	metoprolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008790	[Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein	PMID:18820026
12234055	NAB1	NGFI-A binding protein 1	gene	CHEBI:87681	ranolazine	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	Ranolazine affects the expression of NAB1 protein	PMID:18820026
12234055	NAB1	NGFI-A binding protein 1	gene	CHEBI:87681	ranolazine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein	PMID:18820026
12235605	SLC22A2	solute carrier family 22 member 2	gene	CHEBI:3699	cimetidine	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:D002927	Cimetidine results in decreased activity of SLC22A2 protein	PMID:36669674
12235605	SLC22A2	solute carrier family 22 member 2	gene	CHEBI:81781	tebuconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087114	tebuconazole results in decreased activity of SLC22A2 protein	PMID:36669674
12235605	SLC22A2	solute carrier family 22 member 2	gene	CHEBI:81970	penconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087058	penconazole results in decreased activity of SLC22A2 protein	PMID:36669674
12235618	IL4	interleukin 4	gene	CHEBI:15864	luteolin	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D047311	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]	PMID:33763461
12235618	IL4	interleukin 4	gene	CHEBI:69478	cannabidiol	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D002185	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]	PMID:33763461
12235905	SOD2	superoxide dismutase 2	gene	CHEBI:16199	urea	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014508	Urea results in increased expression of SOD2 protein	PMID:22718889
12235905	SOD2	superoxide dismutase 2	gene	CHEBI:16240	hydrogen peroxide	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Hydrogen Peroxide results in decreased activity of SOD2 protein	PMID:16682413
12235905	SOD2	superoxide dismutase 2	gene	CHEBI:16240	hydrogen peroxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]	PMID:16682413
12235905	SOD2	superoxide dismutase 2	gene	CHEBI:16330	17beta-hydroxy-5alpha-androstan-3-one	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013196	Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]	PMID:16682413
12235905	SOD2	superoxide dismutase 2	gene	CHEBI:26710	sodium chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased expression of SOD2 protein	PMID:22718889
12239792	CYP2B6	cytochrome P450 2B11	gene	CHEBI:10033	warfarin	increases hydroxylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D014859	CYP2B6 protein results in increased hydroxylation of Warfarin	PMID:12637241
12239792	CYP2B6	cytochrome P450 2B11	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of CYP2B6 mRNA	PMID:19952500
12239792	CYP2B6	cytochrome P450 2B11	gene	CHEBI:4027	cyclophosphamide	increases hydroxylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D003520	CYP2B6 protein results in increased hydroxylation of Cyclophosphamide	PMID:16546968
12239792	CYP2B6	cytochrome P450 2B11	gene	CHEBI:4470	dextromethorphan	increases metabolic processing	EXP		E	RGD:6480464	20191114	CTD	MESH:D003915	CYP2B6 protein results in increased metabolism of Dextromethorphan	PMID:12637241
12239792	CYP2B6	cytochrome P450 2B11	gene	CHEBI:6757	mephenytoin	increases hydroxylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D008617	CYP2B6 protein results in increased hydroxylation of Mephenytoin	PMID:12637241
12239792	CYP2B6	cytochrome P450 2B11	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of CYP2B6 protein	PMID:19952500
12239972	ABLIM1	actin binding LIM protein 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ABLIM1 mRNA	PMID:22747577
12240290	P2RY2	purinergic receptor P2Y2	gene	CHEBI:15713	UTP	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D014544	Uridine Triphosphate results in increased activity of P2RY2 protein	PMID:10604969
12240290	P2RY2	purinergic receptor P2Y2	gene	CHEBI:15713	UTP	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014544	[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]	PMID:10604969
12240290	P2RY2	purinergic receptor P2Y2	gene	CHEBI:15843	arachidonic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D016718	[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]	PMID:10604969
12240290	P2RY2	purinergic receptor P2Y2	gene	CHEBI:17489	3',5'-cyclic AMP	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000242	[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]	PMID:10604969
12240290	P2RY2	purinergic receptor P2Y2	gene	CHEBI:34941	5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C077792	pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]	PMID:10604969
12240550	SNX24	sorting nexin 24	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SNX24 mRNA	PMID:27255383
12242625	KCNJ6	potassium inwardly rectifying channel subfamily J member 6	gene	CHEBI:15355	acetylcholine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000109	Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]	PMID:10666054
12242625	KCNJ6	potassium inwardly rectifying channel subfamily J member 6	gene	CHEBI:26216	potassium atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011188	[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]	PMID:10666054
12242625	KCNJ6	potassium inwardly rectifying channel subfamily J member 6	gene	CHEBI:32595	barium(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D001464	Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]	PMID:10666054
12243013	FGF7	fibroblast growth factor 7	gene	CHEBI:17883	hydrogen chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Hydrochloric Acid results in increased expression of FGF7 mRNA	PMID:15883737
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:15367	all-trans-retinoic acid	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	Tretinoin results in increased expression of NOS3 mRNA; Tretinoin results in increased expression of NOS3 protein	PMID:17267746
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:32020	pitavastatin	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in increased activity of NOS3 protein	PMID:15502390
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:32020	pitavastatin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in increased expression of NOS3 mRNA	PMID:15502390
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:4784	enalapril	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	Enalapril results in increased expression of NOS3 mRNA	PMID:12019275
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	FR 173657 inhibits the reaction [Enalapril results in increased expression of NOS3 mRNA]	PMID:12019275
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:71260	pitavastatin(1-)	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in increased activity of NOS3 protein	PMID:15502390
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:71260	pitavastatin(1-)	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in increased expression of NOS3 mRNA	PMID:15502390
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:78420	icariin	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C056599	icariin results in increased activity of NOS3 protein	PMID:17438405
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:9150	simvastatin	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D019821	Simvastatin results in decreased expression of NOS3 mRNA	PMID:11087217
12243345	NOS3	nitric oxide synthase 3	gene	CHEBI:9150	simvastatin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D019821	Simvastatin results in increased expression of NOS3 protein	PMID:11087217
12244264	OCLN	occludin	gene	CHEBI:15367	all-trans-retinoic acid	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	Tretinoin results in increased expression of OCLN mRNA; Tretinoin results in increased expression of OCLN protein	PMID:17035595
12244264	OCLN	occludin	gene	CHEBI:15367	all-trans-retinoic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]	PMID:17035595
12244264	OCLN	occludin	gene	CHEBI:35456	cadmium dichloride	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D019256	Cadmium Chloride results in decreased expression of OCLN protein	PMID:18418844
12244289	BIRC5	baculoviral IAP repeat containing 5	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of BIRC5 mRNA	PMID:22747577
12244446	EGR1	early growth response 1	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	[Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein	PMID:18820026
12244446	EGR1	early growth response 1	gene	CHEBI:6904	metoprolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008790	[Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein	PMID:18820026
12244446	EGR1	early growth response 1	gene	CHEBI:87681	ranolazine	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	Ranolazine affects the expression of EGR1 protein	PMID:18820026
12244446	EGR1	early growth response 1	gene	CHEBI:87681	ranolazine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	[Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein	PMID:18820026
12245252	KCNMB4	potassium calcium-activated channel subfamily M regulatory beta subunit 4	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of KCNMB4 mRNA	PMID:27255383
12246481	SOD1	superoxide dismutase 1	gene	CHEBI:37537	phorbol 13-acetate 12-myristate	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D013755	SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate	PMID:6333936
12246481	SOD1	superoxide dismutase 1	gene	CHEBI:7449	nafenopin	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D009255	SOD1 protein affects the susceptibility to Nafenopin	PMID:6333936
12246481	SOD1	superoxide dismutase 1	gene	CHEBI:77649	2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D009255	SOD1 protein affects the susceptibility to Nafenopin	PMID:6333936
12246481	SOD1	superoxide dismutase 1	gene	CHEBI:8069	phenobarbital	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	SOD1 protein affects the susceptibility to Phenobarbital	PMID:6333936
12246503	ADRB2	adrenoceptor beta 2	gene	CHEBI:135592	amosulalol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C032473	amosulalol binds to and results in decreased activity of ADRB2 protein	PMID:6129981
12246503	ADRB2	adrenoceptor beta 2	gene	CHEBI:18357	(R)-noradrenaline	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine	PMID:2884805
12246503	ADRB2	adrenoceptor beta 2	gene	CHEBI:8499	propranolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011433	[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine	PMID:2884805
12246586	TTR	transthyretin	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of TTR mRNA]	PMID:25419811
12246586	TTR	transthyretin	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]	PMID:25419811
12246586	TTR	transthyretin	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA]	PMID:25419811
12246586	TTR	transthyretin	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA]	PMID:25419811
12246909	MIR15B	microRNA mir-15b	gene	CHEBI:17833	gentamycin	affects expression	EXP		E	RGD:6480464	20210608	CTD	MESH:D005839	Gentamicins affects the expression of MIR15B mRNA	PMID:33290828
12247034	PLN	phospholamban	gene	CHEBI:40279	allopurinol	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000493	Allopurinol affects the expression of PLN mRNA; Allopurinol affects the expression of PLN protein; Allopurinol affects the expression of PLN protein modified form	PMID:17071724
12248831	NAPA	NSF attachment protein alpha	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of NAPA protein	PMID:32991862
12249132	VPS33A	VPS33A core subunit of CORVET and HOPS complexes	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS33A mRNA	PMID:27255383
12249312	UROS	uroporphyrinogen III synthase	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of UROS mRNA	PMID:22747577
12249792	VCPKMT	valosin containing protein lysine methyltransferase	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of VCPKMT mRNA	PMID:22747577
12250216	NCF1	neutrophil cytosolic factor 1	gene	CHEBI:32020	pitavastatin	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in decreased expression of NCF1 mRNA	PMID:15502390
12250216	NCF1	neutrophil cytosolic factor 1	gene	CHEBI:71260	pitavastatin(1-)	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C108475	pitavastatin results in decreased expression of NCF1 mRNA	PMID:15502390
12250353	CAV1	caveolin 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of CAV1 mRNA	PMID:27255383
12251833	SNX17	sorting nexin 17	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of SNX17 mRNA	PMID:27255383
12252074	NPPA	natriuretic peptide A	gene	CHEBI:18357	(R)-noradrenaline	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	Norepinephrine results in increased expression of NPPA protein	PMID:8952593
12252074	NPPA	natriuretic peptide A	gene	CHEBI:28918	(R)-adrenaline	affects abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D004837	NPPA protein affects the abundance of Epinephrine	PMID:2951327
12252074	NPPA	natriuretic peptide A	gene	CHEBI:41879	dexamethasone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D003907	Dexamethasone results in increased expression of NPPA protein	PMID:1934541
12252074	NPPA	natriuretic peptide A	gene	CHEBI:4784	enalapril	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	Enalapril results in decreased expression of NPPA protein	PMID:12019275
12252074	NPPA	natriuretic peptide A	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	FR 173657 inhibits the reaction [Enalapril results in decreased expression of NPPA protein]	PMID:12019275
12252074	NPPA	natriuretic peptide A	gene	CHEBI:8499	propranolol	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D011433	Propranolol results in increased expression of NPPA protein	PMID:2566282
12252219	TNFSF10	TNF superfamily member 10	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TNFSF10 mRNA	PMID:22747577
12252592	CHMP4B	charged multivesicular body protein 4B	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of CHMP4B mRNA	PMID:27255383
12252833	ALOX5	arachidonate 5-lipoxygenase	gene	CHEBI:10112	zileuton	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C063449	zileuton results in decreased activity of ALOX5 protein	PMID:1618819
12253291	CLEC2B	C-type lectin domain family 2 member B	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of CLEC2B mRNA	PMID:22747577
12253987	AGRN	agrin	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of AGRN mRNA	PMID:22747577
12254561	BLOC1S1	biogenesis of lysosomal organelles complex 1 subunit 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of BLOC1S1 mRNA	PMID:27255383
12255685	TARDBP	TAR DNA binding protein	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of TARDBP protein	PMID:22747577
12256662	CAMK1D	calcium/calmodulin dependent protein kinase ID	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of CAMK1D mRNA	PMID:27255383
12257206	TMED2	transmembrane p24 trafficking protein 2	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TMED2 mRNA	PMID:27255383
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:168067	Acetyl tributyl citrate	increases activity	EXP		E	RGD:6480464	20210504	CTD	MESH:C014953	2-acetyltributylcitrate results in increased activity of NR1I2 protein	PMID:21742782
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:28077	rifampicin	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D012293	Rifampin results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:31429	colforsin daropate hydrochloride	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D005576	Colforsin results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:3764	clotrimazole	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003022	Clotrimazole results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:45409	ritonavir	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D019438	Ritonavir results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:45735	troleandomycin	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D014217	Troleandomycin results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:47318	6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:585948	felodipine	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D015736	Felodipine results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:77260	5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D009853	Omeprazole results in increased activity of NR1I2 protein	PMID:27732639
12257278	NR1I2	nuclear receptor subfamily 1 group I member 2	gene	CHEBI:7772	omeprazole	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D009853	Omeprazole results in increased activity of NR1I2 protein	PMID:27732639
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:16240	hydrogen peroxide	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein	PMID:23816505
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:16240	hydrogen peroxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]	PMID:23816505
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:16856	glutathione	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005978	Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]	PMID:23816505
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:17924	D-glucitol	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D013012	Sorbitol results in increased phosphorylation of MAPK1 protein	PMID:12639917
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:26710	sodium chloride	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased phosphorylation of MAPK1 protein	PMID:23816505
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:26710	sodium chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]	PMID:23816505
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:27563	arsenic atom	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D001151	Arsenic results in increased phosphorylation of MAPK1 protein	PMID:29306782
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:28939	N-acetyl-L-cysteine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000111	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]	PMID:23816505
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:30621	diarsenic trioxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C006632	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein	PMID:23236503
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:31429	colforsin daropate hydrochloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005576	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein	PMID:12639917
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:37537	phorbol 13-acetate 12-myristate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013755	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein	PMID:12639917
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:47217	arsane	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D001151	Arsenic results in increased phosphorylation of MAPK1 protein	PMID:29306782
12258672	MAPK1	mitogen-activated protein kinase 1	gene	CHEBI:49900	arsenous acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C032793	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein	PMID:23236503
12258978	TBC1D14	TBC1 domain family member 14	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of TBC1D14 mRNA	PMID:22747577
12259272	EP300	E1A binding protein p300	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20200128	CTD	MESH:C059514	[[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein; Resveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]	PMID:21239502
12260125	CASP8	caspase 8	gene	CHEBI:132230	marbofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	marbofloxacin results in increased expression of CASP8 mRNA	PMID:31005593
12260125	CASP8	caspase 8	gene	CHEBI:132230	marbofloxacin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]	PMID:31005593
12260125	CASP8	caspase 8	gene	CHEBI:51403	1,4-phenylenediamine	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C029728	4-phenylenediamine results in increased activity of CASP8 protein	PMID:20156547
12260125	CASP8	caspase 8	gene	CHEBI:51403	1,4-phenylenediamine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C029728	benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP8 protein]	PMID:20156547
12260125	CASP8	caspase 8	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of CASP8 mRNA	PMID:24582689
12260125	CASP8	caspase 8	gene	CHEBI:7731	ofloxacin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]	PMID:24582689
12261435	ACADVL	acyl-CoA dehydrogenase very long chain	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of ACADVL protein	PMID:19952500
12261866	BHMT	betaine--homocysteine S-methyltransferase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of BHMT protein	PMID:19952500
12262056	PHF10	PHD finger protein 10	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PHF10 mRNA	PMID:22747577
12263390	DLGAP1	DLG associated protein 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of DLGAP1 mRNA	PMID:22747577
12263533	MAB21L2	mab-21 like 2	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of MAB21L2 mRNA]	PMID:25419811
12263533	MAB21L2	mab-21 like 2	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA]	PMID:25419811
12263533	MAB21L2	mab-21 like 2	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA]	PMID:25419811
12263533	MAB21L2	mab-21 like 2	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]	PMID:25419811
12264151	CAST	calpastatin	gene	CHEBI:9241	spironolactone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013148	Spironolactone results in increased expression of CAST protein	PMID:20082611
12264323	TTLL1	TTL family tubulin polyglutamylase complex subunit L1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of TTLL1 mRNA	PMID:22747577
12265583	ATP1A1	ATPase Na+/K+ transporting subunit alpha 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of ATP1A1 mRNA	PMID:27255383
12267221	AIG1	androgen induced 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of AIG1 mRNA	PMID:22747577
12267755	HYAL3	hyaluronidase 3	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of HYAL3 mRNA	PMID:22747577
12268039	ACTA2	actin alpha 2, smooth muscle	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 protein	PMID:33543323
12268039	ACTA2	actin alpha 2, smooth muscle	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]	PMID:33543323
12269304	HSP90AA1	heat shock protein 90 alpha family class A member 1	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of HSP90AA1 protein	PMID:32991862
12272567	WAPL	WAPL cohesin release factor	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of WAPAL mRNA	PMID:22747577
12275117	AGT	angiotensinogen	gene	CHEBI:145568	cilazapril monohydrate	decreases expression	EXP		E	RGD:6480464	20200107	CTD	MESH:D017315	Cilazapril results in decreased expression of AGT protein	PMID:2419701
12275117	AGT	angiotensinogen	gene	CHEBI:26523	reactive oxygen species	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D017382	Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]	PMID:8021468
12275117	AGT	angiotensinogen	gene	CHEBI:27584	aldosterone	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D000450	AGT results in increased abundance of Aldosterone	PMID:2831029
12275117	AGT	angiotensinogen	gene	CHEBI:28790	serotonin	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D012701	AGT protein modified form results in increased susceptibility to Serotonin	PMID:8021468
12275117	AGT	angiotensinogen	gene	CHEBI:28790	serotonin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012701	Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]; Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]	PMID:8021468
12275117	AGT	angiotensinogen	gene	CHEBI:4356	desferrioxamine B	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003676	Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]	PMID:8021468
12276421	MT2A	metallothionein 1H	gene	CHEBI:31823	mercury dichloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008627	Mercuric Chloride results in increased expression of MT2 mRNA	PMID:15590114
12277402	CRH	corticotropin releasing hormone	gene	CHEBI:17650	cortisol	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D006854	CRH protein results in increased abundance of Hydrocortisone	PMID:2831029
12278725	SFT2D1	SFT2 domain containing 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of SFT2D1 mRNA	PMID:27255383
12278777	SLC25A12	solute carrier family 25 member 12	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of SLC25A12 protein	PMID:32991862
12278777	SLC25A12	solute carrier family 25 member 12	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of SLC25A12 mRNA	PMID:22747577
12278824	TM2D2	TM2 domain containing 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TM2D2 mRNA	PMID:22747577
12279055	CRYZ	crystallin zeta	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of CRYZ protein	PMID:19952500
12279429	EPHX1	epoxide hydrolase 1	gene	CHEBI:17907	styrene oxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C013690	CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]	PMID:12051674
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:135004	nefiracetam	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C058876	nefiracetam affects the expression of PTGS2 mRNA	PMID:16105799
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:135004	nefiracetam	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C058876	nefiracetam results in increased expression of PTGS2 protein	PMID:16105799
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:28119	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013749	Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA; Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein	PMID:8660662
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:32243	tolfenamic acid	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C009500	tolfenamic acid results in decreased expression of PTGS2 mRNA	PMID:15198222
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:364453	carprofen	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C007005	carprofen results in decreased expression of PTGS2 mRNA	PMID:15198222
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:44445	nimesulide	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C012655	nimesulide results in decreased expression of PTGS2 mRNA	PMID:15198222
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:4909	etodolac	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D017308	Etodolac results in decreased expression of PTGS2 mRNA	PMID:15198222
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:5855	ibuprofen	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D007052	Ibuprofen results in increased expression of PTGS2 protein	PMID:16105799
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:73458	NS-398	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 protein	PMID:12857884|PMID:15198222
12279597	PTGS2	prostaglandin-endoperoxide synthase 2	gene	CHEBI:9352	sulindac	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013467	Sulindac results in decreased expression of PTGS2 protein	PMID:12857884
12279693	ACTL7A	actin like 7A	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ACTL7A mRNA	PMID:22747577
12280604	ACOX2	acyl-CoA oxidase 2	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of ACOX2 mRNA	PMID:19952500
12280894	CIAPIN1	cytokine induced apoptosis inhibitor 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of CIAPIN1 mRNA	PMID:22747577
12281399	POMC	proopiomelanocortin	gene	CHEBI:17650	cortisol	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D006854	POMC protein results in increased abundance of Hydrocortisone	PMID:2831029
12281399	POMC	proopiomelanocortin	gene	CHEBI:18357	(R)-noradrenaline	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	POMC protein results in increased susceptibility to Norepinephrine	PMID:6279499
12281399	POMC	proopiomelanocortin	gene	CHEBI:27584	aldosterone	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D000450	POMC protein results in increased abundance of Aldosterone	PMID:2831029
12281399	POMC	proopiomelanocortin	gene	CHEBI:6954	Mitotane	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008939	Mitotane results in increased expression of POMC protein alternative form	PMID:8453685
12281399	POMC	proopiomelanocortin	gene	CHEBI:7457	Nalmefene	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C038981	nalmefene results in increased expression of POMC protein alternative form	PMID:3026683
12281399	POMC	proopiomelanocortin	gene	CHEBI:7459	naloxone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D009270	Naloxone results in increased expression of POMC protein	PMID:8277081
12281399	POMC	proopiomelanocortin	gene	CHEBI:7596	nitroprusside	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D009599	Nitroprusside results in increased expression of POMC protein	PMID:2831029
12284259	ABCB11	ATP binding cassette subfamily B member 11	gene	CHEBI:75379	blebbistatin	decreases localization	EXP		E	RGD:6480464	20191114	CTD	MESH:C472645	blebbistatin results in decreased localization of ABCB11 protein	PMID:15826951
12284512	THEMIS2	thymocyte selection associated family member 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of THEMIS2 mRNA	PMID:22747577
12284676	VPS26A	VPS26, retromer complex component A	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS26A mRNA	PMID:27255383
12287062	MYC	MYC proto-oncogene, bHLH transcription factor	gene	CHEBI:31401	cilostazol	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C045645	Cilostazol results in decreased expression of MYC mRNA	PMID:19545562
12287448	DPYSL3	dihydropyrimidinase like 3	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of DPYSL3 mRNA	PMID:22747577
12288301	MMP9	matrix metallopeptidase 9	gene	CHEBI:15379	dioxygen	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D010100	Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein]	PMID:18339021
12288301	MMP9	matrix metallopeptidase 9	gene	CHEBI:17883	hydrogen chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Hydrochloric Acid results in increased expression of MMP9 protein	PMID:18339021
12288301	MMP9	matrix metallopeptidase 9	gene	CHEBI:17883	hydrogen chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006851	Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein]	PMID:18339021
12288301	MMP9	matrix metallopeptidase 9	gene	CHEBI:9241	spironolactone	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013148	Spironolactone results in decreased expression of MMP9 protein	PMID:20082611
12289273	MGST3	microsomal glutathione S-transferase 3	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of MGST3 mRNA	PMID:19952500
12289830	CAPG	capping actin protein, gelsolin like	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CAPG protein	PMID:22747577
12290254	ANK3	ankyrin 3	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of ANK3 mRNA	PMID:27255383
12290491	GDI1	GDP dissociation inhibitor 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of GDI1 protein	PMID:19952500
12290611	UCHL3	ubiquitin C-terminal hydrolase L3	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of UCHL3 protein	PMID:22747577
12290979	SHMT1	serine hydroxymethyltransferase 1	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of SHMT1 protein	PMID:19952500
12292179	RCAN1	regulator of calcineurin 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of RCAN1 mRNA	PMID:22747577
12294444	SLC6A9	solute carrier family 6 member 9	gene	CHEBI:27617	monensin A	affects localization	EXP		E	RGD:6480464	20191114	CTD	MESH:D008985	Monensin affects the localization of SLC6A9 protein	PMID:19473961
12294444	SLC6A9	solute carrier family 6 member 9	gene	CHEBI:27617	monensin A	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008985	Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]	PMID:19473961
12294444	SLC6A9	solute carrier family 6 member 9	gene	CHEBI:37537	phorbol 13-acetate 12-myristate	affects localization	EXP		E	RGD:6480464	20191114	CTD	MESH:D013755	Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein	PMID:19473961
12294444	SLC6A9	solute carrier family 6 member 9	gene	CHEBI:37537	phorbol 13-acetate 12-myristate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013755	Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]	PMID:19473961
12294532	TSG101	tumor susceptibility 101	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TSG101 mRNA	PMID:27255383
12295839	SNX15	sorting nexin 15	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of SNX15 mRNA	PMID:27255383
12296742	DLGAP5	DLG associated protein 5	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of DLGAP5 mRNA	PMID:22747577
12296991	SP1	Sp1 transcription factor	gene	CHEBI:26710	sodium chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased expression of SP1 protein	PMID:23816505
12296991	SP1	Sp1 transcription factor	gene	CHEBI:26710	sodium chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]	PMID:23816505
12296991	SP1	Sp1 transcription factor	gene	CHEBI:90695	anthra[1,9-cd]pyrazol-6(2H)-one	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C432165	pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]	PMID:23816505
12299714	HADH	hydroxyacyl-CoA dehydrogenase	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of HADH mRNA	PMID:19952500
12299714	HADH	hydroxyacyl-CoA dehydrogenase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of HADH mRNA	PMID:19952500
12301253	KIF5A	kinesin family member 5A	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of KIF5A mRNA	PMID:27255383
12302435	COMMD1	copper metabolism domain containing 1	gene	CHEBI:28694	copper atom	decreases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D003300	COMMD1 gene mutant form results in decreased export of Copper	PMID:20433422
12302435	COMMD1	copper metabolism domain containing 1	gene	CHEBI:28694	copper atom	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003300	COMMD1 gene mutant form results in increased abundance of Copper	PMID:22879914
12302435	COMMD1	copper metabolism domain containing 1	gene	CHEBI:30052	copper(0)	decreases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D003300	COMMD1 gene mutant form results in decreased export of Copper	PMID:20433422
12302435	COMMD1	copper metabolism domain containing 1	gene	CHEBI:30052	copper(0)	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003300	COMMD1 gene mutant form results in increased abundance of Copper	PMID:22879914
12303620	ETFDH	electron transfer flavoprotein dehydrogenase	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ETFDH mRNA	PMID:22747577
12304097	KCNJ3	potassium inwardly rectifying channel subfamily J member 3	gene	CHEBI:15355	acetylcholine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000109	Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]	PMID:10666054
12304097	KCNJ3	potassium inwardly rectifying channel subfamily J member 3	gene	CHEBI:26216	potassium atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011188	[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]	PMID:10666054
12304097	KCNJ3	potassium inwardly rectifying channel subfamily J member 3	gene	CHEBI:32595	barium(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D001464	Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]	PMID:10666054
12304129	GLRA1	glycine receptor alpha 1	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GLRA1 mRNA]	PMID:25419811
12304129	GLRA1	glycine receptor alpha 1	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]	PMID:25419811
12304129	GLRA1	glycine receptor alpha 1	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA]	PMID:25419811
12304129	GLRA1	glycine receptor alpha 1	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]	PMID:25419811
12304674	HRC	histidine rich calcium binding protein	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of HRC mRNA	PMID:27255383
12305033	ABITRAM	actin binding transcription modulator	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ABITRAM mRNA	PMID:22747577
12305715	SLC47A1	solute carrier family 47 member 1	gene	CHEBI:38000	uniconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C092705	uniconazole results in decreased activity of SLC47A1 protein	PMID:36669674
12305715	SLC47A1	solute carrier family 47 member 1	gene	CHEBI:81766	hexaconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C409722	hexaconazole results in decreased activity of SLC47A1 protein	PMID:36669674
12305715	SLC47A1	solute carrier family 47 member 1	gene	CHEBI:81781	tebuconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087114	tebuconazole results in decreased activity of SLC47A1 protein	PMID:36669674
12305715	SLC47A1	solute carrier family 47 member 1	gene	CHEBI:81970	penconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087058	penconazole results in decreased activity of SLC47A1 protein	PMID:36669674
12305715	SLC47A1	solute carrier family 47 member 1	gene	CHEBI:81980	triticonazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C412303	triticonazole results in decreased activity of SLC47A1 protein	PMID:36669674
12306176	UQCC1	ubiquinol-cytochrome c reductase complex assembly factor 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20240806	CTD	MESH:C526575	masitinib results in decreased expression of UQCC1 mRNA	PMID:22747577
12306340	ARMC12	armadillo repeat containing 12	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ARMC12 mRNA	PMID:22747577
12306353	LOC474938	glutathione S-transferase A2	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein	PMID:19952500
12306353	LOC474938	glutathione S-transferase A2	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of GSTA3 protein	PMID:19952500
12308896	PARP14	poly(ADP-ribose) polymerase family member 14	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PARP14 mRNA	PMID:22747577
12309295	XIAP	X-linked inhibitor of apoptosis	gene	CHEBI:28748	doxorubicin	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D004317	XIAP affects the susceptibility to Doxorubicin	PMID:16953886
12309515	IL31RA	interleukin 31 receptor A	gene	CHEBI:15864	luteolin	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D047311	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of IL31RA promoter	PMID:33763461
12309515	IL31RA	interleukin 31 receptor A	gene	CHEBI:69478	cannabidiol	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D002185	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of IL31RA promoter	PMID:33763461
12309823	UROD	uroporphyrinogen decarboxylase	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of UROD protein	PMID:22747577
12310262	TOX	thymocyte selection associated high mobility group box	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TOX mRNA	PMID:22747577
12311221	PC	pyruvate carboxylase	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of PC protein	PMID:32991862
12311221	PC	pyruvate carboxylase	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of PC protein	PMID:19952500
12311506	RASGRP2	RAS guanyl releasing protein 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of RASGRP2 mRNA	PMID:22747577
12312469	POR	cytochrome p450 oxidoreductase	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of POR mRNA	PMID:22747577
12312848	DRD2	dopamine receptor D2	gene	CHEBI:26421	pyridines	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011725	Pyridines analog binds to and results in decreased activity of DRD2 protein	PMID:12593651
12312848	DRD2	dopamine receptor D2	gene	CHEBI:8871	risperidone	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D018967	Risperidone binds to and results in decreased activity of DRD2 protein	PMID:16948927
12315254	SMC5	structural maintenance of chromosomes 5	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of SMC5 mRNA	PMID:22747577
12317496	LOC607874	cystatin-C-like	gene	CHEBI:17833	gentamycin	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:D005839	Gentamicins results in increased expression of CST3 protein	PMID:33290828
12317599	STON1	stonin 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of STON1 mRNA	PMID:27255383
12318220	DNM1L	dynamin 1 like	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of DNM1L mRNA	PMID:27255383
12319222	AGO2	argonaute RISC catalytic component 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of AGO2 mRNA	PMID:22747577
12320140	RUNX2	RUNX family transcription factor 2	gene	CHEBI:17154	nicotinamide	decreases expression	EXP		E	RGD:6480464	20210114	CTD	MESH:D009536	Niacinamide results in decreased expression of RUNX2 protein	PMID:22539994
12320140	RUNX2	RUNX family transcription factor 2	gene	CHEBI:17154	nicotinamide	increases acetylation	EXP		E	RGD:6480464	20210114	CTD	MESH:D009536	Niacinamide results in increased acetylation of RUNX2 protein	PMID:22539994
12320140	RUNX2	RUNX family transcription factor 2	gene	CHEBI:17154	nicotinamide	multiple interactions	EXP		E	RGD:6480464	20210114	CTD	MESH:D009536	Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]	PMID:22539994
12320140	RUNX2	RUNX family transcription factor 2	gene	CHEBI:27881	resveratrol	decreases acetylation	EXP		E	RGD:6480464	20210114	CTD	MESH:C059514	Resveratrol results in decreased acetylation of RUNX2 protein	PMID:22539994
12320140	RUNX2	RUNX family transcription factor 2	gene	CHEBI:27881	resveratrol	increases expression	EXP		E	RGD:6480464	20210114	CTD	MESH:C059514	Resveratrol results in increased expression of RUNX2 protein	PMID:22539994
12320140	RUNX2	RUNX family transcription factor 2	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20210114	CTD	MESH:C059514	[Resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of RUNX2 protein]; Resveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein]; SIRT1 protein affects the reaction [Resveratrol results in decreased acetylation of RUNX2 protein]	PMID:21239502|PMID:22539994
12321161	LOC477072	serotransferrin	gene	CHEBI:18248	iron atom	increases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	TF protein results in increased export of Iron	PMID:16806171
12321161	LOC477072	serotransferrin	gene	CHEBI:18248	iron atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]	PMID:16806171
12321161	LOC477072	serotransferrin	gene	CHEBI:82664	iron(0)	increases export	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	TF protein results in increased export of Iron	PMID:16806171
12321161	LOC477072	serotransferrin	gene	CHEBI:82664	iron(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007501	[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]	PMID:16806171
12321204	SNAP23	synaptosome associated protein 23	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SNAP23 mRNA	PMID:27255383
12322085	CHMP6	charged multivesicular body protein 6	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of CHMP6 mRNA	PMID:27255383
12322318	BCAP29	B cell receptor associated protein 29	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of BCAP29 mRNA	PMID:27255383
12323923	LOC478000	phytanoyl-CoA hydroxylase-like	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PHYH mRNA	PMID:22747577
12324640	TERT	telomerase reverse transcriptase	gene	CHEBI:28119	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013749	Tetrachlorodibenzodioxin results in decreased expression of TERT protein	PMID:23850740
12324640	TERT	telomerase reverse transcriptase	gene	CHEBI:64090	tert-butyl hydroperoxide	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D020122	tert-Butylhydroperoxide results in increased activity of TERT protein	PMID:14729356
12324659	UGP2	UDP-glucose pyrophosphorylase 2	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of UGP2 protein	PMID:19952500
12325106	TTC38	tetratricopeptide repeat domain 38	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TTC38 protein	PMID:22747577
12327259	TCN2	transcobalamin 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TCN2 mRNA	PMID:22747577
12327617	LONRF1	LON peptidase N-terminal domain and ring finger 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of LONRF1 mRNA	PMID:22747577
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:15365	acetylsalicylic acid	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D001241	Aspirin results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:31225	antipyrine	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D000983	Antipyrine results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:32169	Sulpyrine	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D004177	Dipyrone results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:46195	paracetamol	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D000082	Acetaminophen results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:47381	diclofenac	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D004008	Diclofenac results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:49662	indometacin	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D007213	Indomethacin results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:5855	ibuprofen	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D007052	Ibuprofen results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:59033	metamizole sodium	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D004177	Dipyrone results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12328669	PTGS1	prostaglandin-endoperoxide synthase 1	gene	CHEBI:8050	phenacetin	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D010615	Phenacetin results in decreased activity of PTGS1 protein alternative form	PMID:12242329
12330261	SNAPIN	SNAP associated protein	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of SNAPIN mRNA	PMID:27255383
12330954	GJA1	gap junction protein alpha 1	gene	CHEBI:35807	N-nitrosodimethylamine	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004128	Dimethylnitrosamine results in decreased expression of GJA1 protein	PMID:15736408
12330959	AR	androgen receptor	gene	CHEBI:31547	eplerenone	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C414690	Eplerenone binds to and results in decreased activity of AR protein	PMID:23242577
12331435	CASQ1	calsequestrin 1	gene	CHEBI:45716	vorinostat	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C111237	Vorinostat results in decreased expression of CASQ1 mRNA	PMID:27255383
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:22984	calcium atom	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	SLC8A1 protein results in increased transport of Calcium	PMID:15375168
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:22984	calcium atom	increases uptake	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	SLC8A1 protein results in increased uptake of Calcium	PMID:14660663
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:22984	calcium atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]	PMID:14660663|PMID:15375168
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:2663	amiodarone	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D000638	Amiodarone results in decreased activity of SLC8A1 protein	PMID:15288574
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:29320	calcium(0)	increases transport	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	SLC8A1 protein results in increased transport of Calcium	PMID:15375168
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:29320	calcium(0)	increases uptake	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	SLC8A1 protein results in increased uptake of Calcium	PMID:14660663
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:29320	calcium(0)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002118	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]	PMID:14660663|PMID:15375168
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:40279	allopurinol	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000493	Allopurinol affects the expression of SLC8A1 mRNA; Allopurinol affects the expression of SLC8A1 protein	PMID:17071724
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein	PMID:18820026
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:6904	metoprolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008790	[Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein	PMID:18820026
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:87681	ranolazine	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	Ranolazine affects the expression of SLC8A1 protein	PMID:18820026
12334269	SLC8A1	solute carrier family 8 member A1	gene	CHEBI:87681	ranolazine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein	PMID:18820026
12335203	CACNB3	calcium voltage-gated channel auxiliary subunit beta 3	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of CACNB3 mRNA	PMID:27255383
12335345	DLA-12	MHC class I DLA-12	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of DLA-12 mRNA	PMID:22747577
12336473	IDH1	isocitrate dehydrogenase (NADP(+)) 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of IDH1 protein	PMID:19952500
12337614	HSP90B1	heat shock protein 90 beta family member 1	gene	CHEBI:29699	tunicamycin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014415	Tunicamycin results in increased expression of HSP90B1 protein	PMID:17416481
12337614	HSP90B1	heat shock protein 90 beta family member 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of HSP90B1 protein	PMID:22747577
12338015	SEC24B	SEC24 homolog B, COPII coat complex component	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SEC24B mRNA	PMID:27255383
12338361	NISCH	nischarin	gene	CHEBI:3757	clonidine (imino form)	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine binds to NISCH protein	PMID:24120658
12338361	NISCH	nischarin	gene	CHEBI:3757	clonidine (imino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]	PMID:24120658
12338361	NISCH	nischarin	gene	CHEBI:4466	dexmedetomidine	affects activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D020927	Dexmedetomidine affects the activity of NISCH	PMID:7486159
12338361	NISCH	nischarin	gene	CHEBI:46631	clonidine	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine binds to NISCH protein	PMID:24120658
12338361	NISCH	nischarin	gene	CHEBI:46631	clonidine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]	PMID:24120658
12338361	NISCH	nischarin	gene	CHEBI:46632	clonidine (amino form)	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine binds to NISCH protein	PMID:24120658
12338361	NISCH	nischarin	gene	CHEBI:46632	clonidine (amino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]	PMID:24120658
12338361	NISCH	nischarin	gene	CHEBI:5862	idazoxan	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D019329	Idazoxan binds to and results in decreased activity of NISCH protein	PMID:8732285
12338361	NISCH	nischarin	gene	CHEBI:93363	2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole	affects binding	EXP		E	RGD:6480464	20191114	CTD	MESH:D009278	Naphazoline binds to NISCH protein	PMID:24120658
12338361	NISCH	nischarin	gene	CHEBI:93363	2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009278	Guanine Nucleotides inhibits the reaction [Naphazoline binds to NISCH protein]	PMID:24120658
12338615	CASP9	caspase 9	gene	CHEBI:192461	toosendanin	increases cleavage	EXP		E	RGD:6480464	20240604	CTD	MESH:C036454	toosendanin results in increased cleavage of CASP9 protein	PMID:36809669
12338615	CASP9	caspase 9	gene	CHEBI:4629	diosgenin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004144	Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein]	PMID:25446497
12338615	CASP9	caspase 9	gene	CHEBI:51403	1,4-phenylenediamine	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C029728	4-phenylenediamine results in increased activity of CASP9 protein	PMID:20156547
12338615	CASP9	caspase 9	gene	CHEBI:51403	1,4-phenylenediamine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C029728	benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP9 protein]	PMID:20156547
12338615	CASP9	caspase 9	gene	CHEBI:60579	calcium oxalate	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D002129	Calcium Oxalate results in increased activity of CASP9 protein	PMID:25446497
12338615	CASP9	caspase 9	gene	CHEBI:60579	calcium oxalate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002129	Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein]	PMID:25446497
12340549	HPD	4-hydroxyphenylpyruvate dioxygenase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of HPD protein	PMID:19952500
12340943	KCNK1	potassium two pore domain channel subfamily K member 1	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of KCNK1 mRNA	PMID:27255383
12341758	AMN1	antagonist of mitotic exit network 1 homolog	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of AMN1 mRNA	PMID:22747577
12342201	SLC47A2	solute carrier family 47 member 2	gene	CHEBI:81766	hexaconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C409722	hexaconazole results in decreased activity of SLC47A2 protein	PMID:36669674
12342201	SLC47A2	solute carrier family 47 member 2	gene	CHEBI:81781	tebuconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087114	tebuconazole results in decreased activity of SLC47A2 protein	PMID:36669674
12342201	SLC47A2	solute carrier family 47 member 2	gene	CHEBI:81970	penconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087058	penconazole results in decreased activity of SLC47A2 protein	PMID:36669674
12342642	ACAA1	acetyl-CoA acyltransferase 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of ACAA1 mRNA	PMID:19952500
12342968	SLA	Src like adaptor	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of SLA mRNA	PMID:22747577
12344307	R3HDM2	R3H domain containing 2	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of R3HDM2 mRNA	PMID:22747577
12344516	VIP	vasoactive intestinal peptide	gene	CHEBI:27638	cobalt atom	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D003035	Cobalt results in decreased expression of VIP protein	PMID:3711722
12344516	VIP	vasoactive intestinal peptide	gene	CHEBI:28748	doxorubicin	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D004317	Doxorubicin results in decreased expression of VIP protein	PMID:3711722
12344516	VIP	vasoactive intestinal peptide	gene	CHEBI:8499	propranolol	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D011433	Propranolol results in decreased expression of VIP protein	PMID:2566282
12344768	ALB	albumin	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of ALB mRNA]	PMID:25419811
12344768	ALB	albumin	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA]	PMID:25419811
12344768	ALB	albumin	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA]	PMID:25419811
12344768	ALB	albumin	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]	PMID:25419811
12344792	CPT1A	carnitine palmitoyltransferase 1A	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of CPT1A mRNA	PMID:19952500
12344815	HSP70	heat shock protein 70	gene	CHEBI:16243	quercetin	decreases expression	EXP		E	RGD:6480464	20230307	CTD	MESH:D011794	Quercetin results in decreased expression of HSP70 protein	PMID:17009600
12344815	HSP70	heat shock protein 70	gene	CHEBI:16412	lipopolysaccharide	multiple interactions	EXP		E	RGD:6480464	20230307	CTD	MESH:D008070	HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]	PMID:32899721
12344815	HSP70	heat shock protein 70	gene	CHEBI:22977	cadmium atom	increases expression	EXP		E	RGD:6480464	20230307	CTD	MESH:D002104	Cadmium results in increased expression of HSP70 protein	PMID:12915104
12344815	HSP70	heat shock protein 70	gene	CHEBI:29678	sodium arsenite	increases expression	EXP		E	RGD:6480464	20230307	CTD	MESH:C017947	sodium arsenite results in increased expression of HSP70 protein	PMID:31940135
12344815	HSP70	heat shock protein 70	gene	CHEBI:29678	sodium arsenite	multiple interactions	EXP		E	RGD:6480464	20230307	CTD	MESH:C017947	carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]; leucinostatin A promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]	PMID:31940135
12344815	HSP70	heat shock protein 70	gene	CHEBI:29866	arsenite(3-)	increases expression	EXP		E	RGD:6480464	20230307	CTD	MESH:C015001	arsenite results in increased expression of HSP70 mRNA	PMID:32899721
12344815	HSP70	heat shock protein 70	gene	CHEBI:29866	arsenite(3-)	multiple interactions	EXP		E	RGD:6480464	20230307	CTD	MESH:C015001	HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]	PMID:32899721
12344815	HSP70	heat shock protein 70	gene	CHEBI:3440	carvacrol	multiple interactions	EXP		E	RGD:6480464	20230307	CTD	MESH:C073316	carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]	PMID:31940135
12344815	HSP70	heat shock protein 70	gene	CHEBI:45716	vorinostat	decreases expression	EXP		E	RGD:6480464	20230307	CTD	MESH:C111237	Vorinostat results in decreased expression of HSP70 mRNA	PMID:27255383
12347185	DLA-64	MHC class I DLA-64	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of DLA-64 mRNA	PMID:22747577
12347408	RELA	RELA proto-oncogene, NF-kB subunit	gene	CHEBI:16412	lipopolysaccharide	increases phosphorylation	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	Lipopolysaccharides results in increased phosphorylation of RELA protein	PMID:32899721
12347408	RELA	RELA proto-oncogene, NF-kB subunit	gene	CHEBI:16412	lipopolysaccharide	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]	PMID:32899721
12347408	RELA	RELA proto-oncogene, NF-kB subunit	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	[[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased localization of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased localization of and results in increased activity of RELA protein]	PMID:21239502
12347408	RELA	RELA proto-oncogene, NF-kB subunit	gene	CHEBI:29866	arsenite(3-)	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:C015001	arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]	PMID:32899721
12347408	RELA	RELA proto-oncogene, NF-kB subunit	gene	CHEBI:73458	NS-398	decreases localization	EXP		E	RGD:6480464	20191114	CTD	MESH:C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased localization of RELA protein	PMID:12857884
12347408	RELA	RELA proto-oncogene, NF-kB subunit	gene	CHEBI:9352	sulindac	decreases localization	EXP		E	RGD:6480464	20191114	CTD	MESH:D013467	Sulindac results in decreased localization of RELA protein	PMID:12857884
12349882	ACAA2	acetyl-CoA acyltransferase 2	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of ACAA2 mRNA	PMID:19952500
12349882	ACAA2	acetyl-CoA acyltransferase 2	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of ACAA2 mRNA	PMID:19952500
12351150	TNNI3K	TNNI3 interacting kinase	gene	CHEBI:45716	vorinostat	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C111237	Vorinostat results in decreased expression of TNNI3K mRNA	PMID:27255383
12351879	CYP3A26	cytochrome P450 3A26	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of CYP3A26 mRNA	PMID:19952500
12351879	CYP3A26	cytochrome P450 3A26	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of CYP3A26 mRNA	PMID:19952500
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:10033	warfarin	increases hydroxylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D014859	CYP3A12 protein results in increased hydroxylation of Warfarin	PMID:12637241
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:17907	styrene oxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C013690	CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]	PMID:12051674
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of CYP3A12 mRNA	PMID:19952500
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:47519	ketoconazole	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D007654	Ketoconazole results in decreased activity of CYP3A12 protein	PMID:15677349
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:47519	ketoconazole	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007654	Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam]	PMID:15677349
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:49575	diazepam	increases hydroxylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D003975	CYP3A12 protein results in increased hydroxylation of Diazepam	PMID:15677349
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:49575	diazepam	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003975	Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam]	PMID:15677349
12351896	CYP3A12	cytochrome P-450 3A12	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of CYP3A12 protein	PMID:19952500
12353587	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	gene	CHEBI:17361	cytidine 5'-monophosphate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003568	[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate	PMID:2579070
12353587	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	gene	CHEBI:24848	inositol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007294	[Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate; Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]	PMID:2579070
12353587	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	gene	CHEBI:32888	gamma-hexachlorocyclohexane	affects activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D001556	Hexachlorocyclohexane affects the activity of CDIPT protein	PMID:2579070
12353587	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	gene	CHEBI:32888	gamma-hexachlorocyclohexane	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D001556	[Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate	PMID:2579070
12353587	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	gene	CHEBI:39095	delta-hexachlorocyclohexane	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C086916	delta-hexachlorocyclohexane results in decreased activity of CDIPT protein	PMID:2579070
12353587	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	gene	CHEBI:39095	delta-hexachlorocyclohexane	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C086916	[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate	PMID:2579070
12353587	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	gene	CHEBI:53013	3'-CMP	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003568	[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate	PMID:2579070
12353617	TMEM260	transmembrane protein 260	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TMEM260 mRNA	PMID:22747577
12355366	CCL2	C-C motif chemokine ligand 2	gene	CHEBI:15864	luteolin	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D047311	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL2 promoter	PMID:33763461
12355366	CCL2	C-C motif chemokine ligand 2	gene	CHEBI:17833	gentamycin	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:D005839	Gentamicins results in increased expression of CCL2 protein	PMID:33290828
12355366	CCL2	C-C motif chemokine ligand 2	gene	CHEBI:69478	cannabidiol	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D002185	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL2 promoter	PMID:33763461
12357133	MYL9	myosin light chain 9	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog]	PMID:20510202
12358149	KIF5C	kinesin family member 5C	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of KIF5C mRNA	PMID:27255383
12358542	KRT18	keratin 18	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of KRT18 protein	PMID:19952500
12358831	ALDH5A1	aldehyde dehydrogenase 5 family member A1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of ALDH5A1 mRNA	PMID:22747577
12359874	ECHS1	enoyl-CoA hydratase, short chain 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of ECHS1 protein	PMID:19952500
12362351	B9D2	B9 domain containing 2	gene	CHEBI:17347	testosterone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013739	Testosterone results in increased expression of TGFB1 mRNA	PMID:17157324
12362351	B9D2	B9 domain containing 2	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of TGFB1 mRNA; ochratoxin A results in increased expression of TGFB1 protein	PMID:33543323
12362351	B9D2	B9 domain containing 2	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]	PMID:33543323
12362811	CAMK2G	calcium/calmodulin dependent protein kinase II gamma	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CAMK2G mRNA	PMID:22747577
12362885	STYXL1	serine/threonine/tyrosine interacting like 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of STYXL1 mRNA	PMID:22747577
12364239	NLRP3	NLR family pyrin domain containing 3	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of NLRP3 mRNA; ochratoxin A results in increased expression of NLRP3 protein	PMID:33543323
12364239	NLRP3	NLR family pyrin domain containing 3	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]	PMID:33543323
12365506	ADRB1	adrenoceptor beta 1	gene	CHEBI:135359	denopamine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C037293	denopamine binds to and results in increased activity of ADRB1 protein	PMID:3831029
12365506	ADRB1	adrenoceptor beta 1	gene	CHEBI:135592	amosulalol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C032473	amosulalol binds to and results in decreased activity of ADRB1 protein	PMID:6129981
12365506	ADRB1	adrenoceptor beta 1	gene	CHEBI:18357	(R)-noradrenaline	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	Norepinephrine results in increased activity of ADRB1 protein	PMID:10344530
12365509	STING1	stimulator of interferon response cGAMP interactor 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of TMEM173 mRNA	PMID:22747577
12365935	KLK6	kallikrein related peptidase 6	gene	CHEBI:31516	Doramectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C084101	ABCB1 gene mutant form affects the reaction [doramectin affects the expression of KLK6 mRNA]	PMID:25419811
12365935	KLK6	kallikrein related peptidase 6	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]	PMID:25419811
12365935	KLK6	kallikrein related peptidase 6	gene	CHEBI:50345	milbemycin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C027837	ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA]	PMID:25419811
12365935	KLK6	kallikrein related peptidase 6	gene	CHEBI:6078	ivermectin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007559	ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]	PMID:25419811
12366564	ANKRD26	ankyrin repeat domain containing 26	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ANKRD26 mRNA	PMID:22747577
12366906	POLE2	DNA polymerase epsilon 2, accessory subunit	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of DNAAF2 mRNA	PMID:27255383
12367266	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of OGT mRNA	PMID:22747577
12368635	PTH	parathyroid hormone	gene	CHEBI:31801	Maxacalcitol	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C051883	maxacalcitol results in decreased expression of PTH protein	PMID:10027919
12368635	PTH	parathyroid hormone	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PTH mRNA	PMID:22747577
12370161	INS	insulin	gene	CHEBI:17234	glucose	decreases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D005947	INS protein results in decreased abundance of Glucose	PMID:1646414
12370161	INS	insulin	gene	CHEBI:17234	glucose	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005947	[INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin	PMID:1013176|PMID:140932
12370161	INS	insulin	gene	CHEBI:17634	D-glucose	decreases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D005947	INS protein results in decreased abundance of Glucose	PMID:1646414
12370161	INS	insulin	gene	CHEBI:17634	D-glucose	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005947	[INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin	PMID:1013176|PMID:140932
12370161	INS	insulin	gene	CHEBI:17650	cortisol	affects abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D006854	INS protein affects the abundance of Hydrocortisone	PMID:1324617
12370161	INS	insulin	gene	CHEBI:17650	cortisol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006854	Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]	PMID:1324617
12370161	INS	insulin	gene	CHEBI:26216	potassium atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011188	[INS protein co-treated with Glucose] results in decreased abundance of Potassium	PMID:1013176|PMID:140932
12370161	INS	insulin	gene	CHEBI:26708	sodium atom	affects response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D012964	INS protein affects the susceptibility to Sodium	PMID:1324617
12370161	INS	insulin	gene	CHEBI:26708	sodium atom	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012964	INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins]; Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]	PMID:1324617
12370161	INS	insulin	gene	CHEBI:31429	colforsin daropate hydrochloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005576	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein	PMID:12639917
12370161	INS	insulin	gene	CHEBI:37537	phorbol 13-acetate 12-myristate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013755	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein	PMID:12639917
12370161	INS	insulin	gene	CHEBI:3892	corticotropin	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D000324	INS protein results in increased abundance of Adrenocorticotropic Hormone	PMID:1646414
12370161	INS	insulin	gene	CHEBI:42758	aldehydo-D-glucose	decreases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D005947	INS protein results in decreased abundance of Glucose	PMID:1646414
12370161	INS	insulin	gene	CHEBI:42758	aldehydo-D-glucose	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005947	[INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin	PMID:1013176|PMID:140932
12370161	INS	insulin	gene	CHEBI:4551	digoxin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004077	[INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin	PMID:1013176|PMID:140932
12370161	INS	insulin	gene	CHEBI:9937	vasopressin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014667	INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins]	PMID:1324617
12370168	ABHD14A	abhydrolase domain containing 14A	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of ABHD14A mRNA	PMID:22747577
12370207	LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of LAMTOR1 mRNA	PMID:27255383
12372577	PCOLCE2	procollagen C-endopeptidase enhancer 2	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of PCOLCE2 mRNA	PMID:22747577
12372873	DES	desmin	gene	CHEBI:3011	benazepril	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C044946	benazepril results in decreased expression of DES mRNA	PMID:20137276
12373160	TNF	tumor necrosis factor	gene	CHEBI:132230	marbofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	marbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF protein	PMID:31005593
12373160	TNF	tumor necrosis factor	gene	CHEBI:16412	lipopolysaccharide	increases expression	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	Lipopolysaccharides results in increased expression of TNF mRNA	PMID:32899721
12373160	TNF	tumor necrosis factor	gene	CHEBI:16412	lipopolysaccharide	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:D008070	arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]	PMID:32899721
12373160	TNF	tumor necrosis factor	gene	CHEBI:26523	reactive oxygen species	increases abundance	EXP		E	RGD:6480464	20191114	CTD	MESH:D017382	TNF protein results in increased abundance of Reactive Oxygen Species	PMID:14973143
12373160	TNF	tumor necrosis factor	gene	CHEBI:26523	reactive oxygen species	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D017382	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Vitamin E inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]	PMID:14973143
12373160	TNF	tumor necrosis factor	gene	CHEBI:2682	amphotericin B	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000666	Amphotericin B results in increased expression of TNF protein	PMID:24105867
12373160	TNF	tumor necrosis factor	gene	CHEBI:29866	arsenite(3-)	multiple interactions	EXP		E	RGD:6480464	20220405	CTD	MESH:C015001	arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]	PMID:32899721
12373160	TNF	tumor necrosis factor	gene	CHEBI:33234	vitamin E	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D024502	Vitamin E inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]	PMID:14973143
12373160	TNF	tumor necrosis factor	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of TNF mRNA	PMID:33543323
12373160	TNF	tumor necrosis factor	gene	CHEBI:7719	ochratoxin A	increases secretion	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased secretion of TNF protein	PMID:33543323
12373160	TNF	tumor necrosis factor	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein	PMID:24582689
12373359	MAGEF1	MAGE family member F1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of MAGEF1 mRNA	PMID:22747577
12373364	ADRA2C	adrenoceptor alpha 2C	gene	CHEBI:3757	clonidine (imino form)	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	ADRA2C protein results in increased susceptibility to Clonidine	PMID:16814767
12373364	ADRA2C	adrenoceptor alpha 2C	gene	CHEBI:46631	clonidine	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	ADRA2C protein results in increased susceptibility to Clonidine	PMID:16814767
12373364	ADRA2C	adrenoceptor alpha 2C	gene	CHEBI:46632	clonidine (amino form)	increases response to substance	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	ADRA2C protein results in increased susceptibility to Clonidine	PMID:16814767
12374086	JUN	Jun proto-oncogene, AP-1 transcription factor subunit	gene	CHEBI:26710	sodium chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased expression of JUN protein	PMID:23816505
12374086	JUN	Jun proto-oncogene, AP-1 transcription factor subunit	gene	CHEBI:26710	sodium chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]	PMID:23816505
12374086	JUN	Jun proto-oncogene, AP-1 transcription factor subunit	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of JUN mRNA	PMID:22747577
12374086	JUN	Jun proto-oncogene, AP-1 transcription factor subunit	gene	CHEBI:90695	anthra[1,9-cd]pyrazol-6(2H)-one	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C432165	pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]	PMID:23816505
12377502	IGFBP7	insulin like growth factor binding protein 7	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of IGFBP7 mRNA	PMID:22747577
12377511	RAB27A	RAB27A, member RAS oncogene family	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of RAB27A mRNA	PMID:27255383
12377712	SYTL4	synaptotagmin like 4	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SYTL4 mRNA	PMID:27255383
12377761	CLDN4	claudin 4	gene	CHEBI:15367	all-trans-retinoic acid	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	Tretinoin results in increased expression of CLDN4 mRNA; Tretinoin results in increased expression of CLDN4 protein	PMID:17035595
12377761	CLDN4	claudin 4	gene	CHEBI:15367	all-trans-retinoic acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D014212	CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]	PMID:17035595
12377761	CLDN4	claudin 4	gene	CHEBI:16199	urea	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014508	Urea results in increased expression of CLDN4 protein	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:16240	hydrogen peroxide	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Hydrogen Peroxide results in increased expression of CLDN4 protein	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:16240	hydrogen peroxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:16856	glutathione	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005978	Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:16899	D-mannitol	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008353	Mannitol results in increased expression of CLDN4 protein	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:26710	sodium chloride	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased expression of CLDN4 protein	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:26710	sodium chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:28939	N-acetyl-L-cysteine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000111	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:77986	dibenziodolium	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C007517	diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]	PMID:23816505
12377761	CLDN4	claudin 4	gene	CHEBI:90695	anthra[1,9-cd]pyrazol-6(2H)-one	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C432165	pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]	PMID:23816505
12377803	EDN1	endothelin 1	gene	CHEBI:28790	serotonin	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D012701	Serotonin results in increased activity of EDN1 protein	PMID:9918753
12377803	EDN1	endothelin 1	gene	CHEBI:5000	fenfluramine	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D005277	Fenfluramine results in increased activity of EDN1 protein	PMID:9918753
12377803	EDN1	endothelin 1	gene	CHEBI:88212	lead(II) chloride	increases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:C029891	lead chloride results in increased secretion of EDN1 protein	PMID:15915659
12379440	TSLP	thymic stromal lymphopoietin	gene	CHEBI:15864	luteolin	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D047311	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of TSLP promoter	PMID:33763461
12379440	TSLP	thymic stromal lymphopoietin	gene	CHEBI:69478	cannabidiol	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D002185	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of TSLP promoter	PMID:33763461
12380597	GATA4	GATA binding protein 4	gene	CHEBI:4784	enalapril	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D004656	[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein	PMID:18820026
12380597	GATA4	GATA binding protein 4	gene	CHEBI:6904	metoprolol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008790	[Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein	PMID:18820026
12380597	GATA4	GATA binding protein 4	gene	CHEBI:87681	ranolazine	affects expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	Ranolazine affects the expression of GATA4 protein	PMID:18820026
12380597	GATA4	GATA binding protein 4	gene	CHEBI:87681	ranolazine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000069458	[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein	PMID:18820026
12380628	GOT1	glutamic-oxaloacetic transaminase 1	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of GOT1 protein	PMID:19952500
12380628	GOT1	glutamic-oxaloacetic transaminase 1	gene	CHEBI:9728	trimethaphan	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D014294	Trimethaphan results in increased expression of GOT1 protein	PMID:6848019
12380902	MPDZ	multiple PDZ domain crumbs cell polarity complex component	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of MPDZ mRNA	PMID:22747577
12381371	TNS1	tensin 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of TNS1 mRNA	PMID:22747577
12383542	DPCD	deleted in primary ciliary dyskinesia homolog	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of DPCD mRNA	PMID:22747577
12384201	GSTA4	glutathione S-transferase alpha 4	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of GSTA4 mRNA	PMID:19952500
12384201	GSTA4	glutathione S-transferase alpha 4	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of GSTA4 mRNA	PMID:22747577
12384201	GSTA4	glutathione S-transferase alpha 4	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of GSTA4 mRNA	PMID:19952500
12385838	GMFB	glia maturation factor beta	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of GMFB mRNA	PMID:22747577
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:16240	hydrogen peroxide	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein	PMID:23816505
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:16240	hydrogen peroxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D006861	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]	PMID:23816505
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:16856	glutathione	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005978	Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]	PMID:23816505
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:17924	D-glucitol	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D013012	Sorbitol results in increased phosphorylation of MAPK3 protein	PMID:12639917
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:26710	sodium chloride	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Sodium Chloride results in increased phosphorylation of MAPK3 protein	PMID:23816505
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:26710	sodium chloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D012965	Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]	PMID:23816505
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:27563	arsenic atom	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D001151	Arsenic results in increased phosphorylation of MAPK3 protein	PMID:29306782
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:28939	N-acetyl-L-cysteine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D000111	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]	PMID:23816505
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:30621	diarsenic trioxide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C006632	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein	PMID:23236503
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:31429	colforsin daropate hydrochloride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005576	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein	PMID:12639917
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:37537	phorbol 13-acetate 12-myristate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013755	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein	PMID:12639917
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:47217	arsane	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D001151	Arsenic results in increased phosphorylation of MAPK3 protein	PMID:29306782
12388002	MAPK3	mitogen-activated protein kinase 3	gene	CHEBI:49900	arsenous acid	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C032793	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein	PMID:23236503
12388118	TNFRSF1A	TNF receptor superfamily member 1A	gene	CHEBI:132230	marbofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	marbofloxacin results in increased expression of TNFRSF1A mRNA; marbofloxacin results in increased expression of TNFRSF1A protein	PMID:31005593
12388118	TNFRSF1A	TNF receptor superfamily member 1A	gene	CHEBI:132230	marbofloxacin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C080260	TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]	PMID:31005593
12388118	TNFRSF1A	TNF receptor superfamily member 1A	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein	PMID:24582689
12388118	TNFRSF1A	TNF receptor superfamily member 1A	gene	CHEBI:7731	ofloxacin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]	PMID:24582689
12388250	OXCT1	3-oxoacid CoA-transferase 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of OXCT1 protein	PMID:22747577
12388284	VPS13B	vacuolar protein sorting 13 homolog B	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS13B mRNA	PMID:27255383
12389759	CBY1	chibby 1, beta catenin antagonist	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of CBY1 mRNA	PMID:27255383
12391828	SLC22A5	solute carrier family 22 member 5	gene	CHEBI:38000	uniconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C092705	uniconazole results in decreased activity of SLC22A5 protein	PMID:36669674
12391828	SLC22A5	solute carrier family 22 member 5	gene	CHEBI:81781	tebuconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087114	tebuconazole results in decreased activity of SLC22A5 protein	PMID:36669674
12391828	SLC22A5	solute carrier family 22 member 5	gene	CHEBI:81970	penconazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C087058	penconazole results in decreased activity of SLC22A5 protein	PMID:36669674
12391828	SLC22A5	solute carrier family 22 member 5	gene	CHEBI:81980	triticonazole	decreases activity	EXP		E	RGD:6480464	20230801	CTD	MESH:C412303	triticonazole results in decreased activity of SLC22A5 protein	PMID:36669674
12391987	BAX	BCL2 associated X, apoptosis regulator	gene	CHEBI:192461	toosendanin	increases expression	EXP		E	RGD:6480464	20240604	CTD	MESH:C036454	toosendanin results in increased expression of BAX mRNA; toosendanin results in increased expression of BAX protein	PMID:36809669
12391987	BAX	BCL2 associated X, apoptosis regulator	gene	CHEBI:9241	spironolactone	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D013148	Spironolactone results in decreased expression of BAX protein	PMID:20082611
12392076	BTBD3	BTB domain containing 3	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of BTBD3 mRNA	PMID:22747577
12392149	LAMTOR2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of LAMTOR2 mRNA	PMID:27255383
12392198	RAB44	RAB44, member RAS oncogene family	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of RAB44 mRNA	PMID:22747577
12392574	SEC63	SEC63 homolog, protein translocation regulator	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SEC63 mRNA	PMID:27255383
12393596	UQCRC1	ubiquinol-cytochrome c reductase core protein 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of UQCRC1 protein	PMID:19952500
12398527	AP2S1	adaptor related protein complex 2 subunit sigma 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of AP2S1 mRNA	PMID:27255383
12399007	COPG1	COPI coat complex subunit gamma 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of COPG1 mRNA	PMID:27255383
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:10093	yohimbine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D015016	Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:18357	(R)-noradrenaline	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	Norepinephrine results in increased activity of PIK3CG protein	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:18357	(R)-noradrenaline	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:26034	phosphatidylinositol 3-phosphate	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C055525	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:3757	clonidine (imino form)	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in increased activity of PIK3CG protein	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:3757	clonidine (imino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:46631	clonidine	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in increased activity of PIK3CG protein	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:46631	clonidine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:46632	clonidine (amino form)	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in increased activity of PIK3CG protein	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:46632	clonidine (amino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]	PMID:15958164
12399201	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	gene	CHEBI:65329	LY294002	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]	PMID:15958164
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:133151	methyl beta-cyclodextrin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C108732	methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]	PMID:21671308
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:199449	YM-254890	multiple interactions	EXP		E	RGD:6480464	20231219	CTD	MESH:C475455	YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein]	PMID:21671308
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:49662	indometacin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D007213	Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]	PMID:21671308
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:61048	ganglioside GM1	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D005677	G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein]	PMID:21334356|PMID:21671308
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:6736	melittin	increases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:D008555	Melitten results in increased secretion of HEXB protein	PMID:21334356
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:6736	melittin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D008555	G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein]	PMID:21334356
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:78496	mastoparan	increases secretion	EXP		E	RGD:6480464	20191114	CTD	MESH:C037500	mastoparan results in increased secretion of HEXB protein	PMID:21671308
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:78496	mastoparan	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C037500	G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein]	PMID:21671308
12399632	HEXB	hexosaminidase subunit beta	gene	CHEBI:8711	quinacrine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D011796	Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]	PMID:21671308
12400151	VPS52	VPS52 subunit of GARP complex	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS52 mRNA	PMID:27255383
12401213	BNIP1	BCL2 interacting protein 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of BNIP1 mRNA	PMID:27255383
12402456	CA3	carbonic anhydrase 3	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of CA3 protein	PMID:19952500
12403252	GSDMD	gasdermin D	gene	CHEBI:7719	ochratoxin A	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	ochratoxin A results in increased expression of GSDMD mRNA; ochratoxin A results in increased expression of GSDMD protein	PMID:33543323
12403252	GSDMD	gasdermin D	gene	CHEBI:7719	ochratoxin A	multiple interactions	EXP		E	RGD:6480464	20210608	CTD	MESH:C025589	CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]	PMID:33543323
12404079	IL13	interleukin 13	gene	CHEBI:15864	luteolin	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D047311	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]	PMID:33763461
12404079	IL13	interleukin 13	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of IL13 mRNA	PMID:22747577
12404079	IL13	interleukin 13	gene	CHEBI:69478	cannabidiol	multiple interactions	EXP		E	RGD:6480464	20211207	CTD	MESH:D002185	[Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]	PMID:33763461
12404196	CDADC1	cytidine and dCMP deaminase domain containing 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of CDADC1 mRNA	PMID:22747577
12404336	KCTD19	potassium channel tetramerization domain containing 19	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of KCTD19 mRNA	PMID:22747577
12405277	HSD11B1	hydroxysteroid 11-beta dehydrogenase 1	gene	CHEBI:16412	lipopolysaccharide	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D008070	Lipopolysaccharides results in increased expression of HSD11B1 mRNA	PMID:21798686
12405277	HSD11B1	hydroxysteroid 11-beta dehydrogenase 1	gene	CHEBI:41879	dexamethasone	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D003907	Dexamethasone results in increased expression of HSD11B1 mRNA	PMID:21798686
12405409	CASP12	caspase 12	gene	CHEBI:7731	ofloxacin	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D015242	Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein	PMID:24582689
12408957	HTR1B	5-hydroxytryptamine receptor 1B	gene	CHEBI:3374	capsaicin	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D002211	HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin]	PMID:16880765
12409610	AGXT	alanine--glyoxylate and serine--pyruvate aminotransferase	gene	CHEBI:3750	clofibrate	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in decreased expression of AGXT protein	PMID:19952500
12409610	AGXT	alanine--glyoxylate and serine--pyruvate aminotransferase	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of AGXT protein	PMID:19952500
12409625	GADD45A	growth arrest and DNA damage inducible alpha	gene	CHEBI:64090	tert-butyl hydroperoxide	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D020122	tert-Butylhydroperoxide results in decreased expression of GADD45A protein	PMID:14729356
12409625	GADD45A	growth arrest and DNA damage inducible alpha	gene	CHEBI:64090	tert-butyl hydroperoxide	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D020122	tert-Butylhydroperoxide results in increased expression of GADD45A protein	PMID:14729356
12409798	LOC477540	SEC14-like protein 3	gene	CHEBI:8069	phenobarbital	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in decreased expression of SEC14L3 protein	PMID:19952500
12411231	HPS4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of HPS4 mRNA	PMID:27255383
12413958	MIR30A	microRNA mir-30a	gene	CHEBI:17833	gentamycin	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:D005839	Gentamicins results in increased expression of MIR30A mRNA	PMID:33290828
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:10093	yohimbine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D015016	Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:18357	(R)-noradrenaline	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	Norepinephrine results in increased phosphorylation of PRKCZ protein	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:18357	(R)-noradrenaline	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D009638	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein]	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:3757	clonidine (imino form)	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in increased phosphorylation of PRKCZ protein	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:3757	clonidine (imino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:46631	clonidine	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in increased phosphorylation of PRKCZ protein	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:46631	clonidine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:46632	clonidine (amino form)	increases phosphorylation	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	Clonidine results in increased phosphorylation of PRKCZ protein	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:46632	clonidine (amino form)	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D003000	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]	PMID:15958164
12414217	PRKCZ	protein kinase C zeta	gene	CHEBI:65329	LY294002	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein]	PMID:15958164
12414357	EZR	ezrin	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of EZR protein	PMID:32991862
12415481	HERPUD1	homocysteine inducible ER protein with ubiquitin like domain 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of HERPUD1 mRNA	PMID:22747577
12415572	LRP1	LDL receptor related protein 1	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of LRP1 mRNA	PMID:22747577
12416162	TFRC	transferrin receptor	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of TFRC mRNA	PMID:27255383
12416750	ACP5	acid phosphatase 5, tartrate resistant	gene	CHEBI:27881	resveratrol	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C059514	Resveratrol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]	PMID:21239502
12416923	RAB3IP	RAB3A interacting protein	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of RAB3IP mRNA	PMID:27255383
12419758	SNX16	sorting nexin 16	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SNX16 mRNA	PMID:27255383
12420356	KCNS3	potassium voltage-gated channel modifier subfamily S member 3	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of KCNS3 mRNA	PMID:27255383
12420682	KLHL5	kelch like family member 5	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of KLHL5 mRNA	PMID:22747577
12421372	LOC102151342	ATP synthase subunit d, mitochondrial-like	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	increases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in increased expression of ATP5PD protein	PMID:32991862
12421480	KCNH2	potassium voltage-gated channel subfamily H member 2	gene	CHEBI:2896	astemizole	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D016589	Astemizole binds to and results in decreased activity of KCNH2 protein	PMID:12388285
12421480	KCNH2	potassium voltage-gated channel subfamily H member 2	gene	CHEBI:3720	cisapride	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D020117	Cisapride binds to and results in decreased activity of KCNH2 protein	PMID:12388285
12421480	KCNH2	potassium voltage-gated channel subfamily H member 2	gene	CHEBI:9453	Terfenadine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D016593	Terfenadine binds to and results in decreased activity of KCNH2 protein	PMID:12388285
12421480	KCNH2	potassium voltage-gated channel subfamily H member 2	gene	CHEBI:95129	4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D020117	Cisapride binds to and results in decreased activity of KCNH2 protein	PMID:12388285
12422763	PEBP4	phosphatidylethanolamine binding protein 4	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of PEBP4 mRNA	PMID:22747577
12424322	CDH1	cadherin 1	gene	CHEBI:138858	Azaspiracid	decreases uptake	EXP		E	RGD:6480464	20191114	CTD	MESH:C406592	azaspiracid results in decreased uptake of CDH1 protein modified form	PMID:20547569
12424596	OCA2	OCA2 melanosomal transmembrane protein	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of OCA2 mRNA	PMID:22747577
12425093	NRAS	NRAS proto-oncogene, GTPase	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of NRAS mRNA	PMID:22747577
12425104	FASLG	Fas ligand	gene	CHEBI:3441	carvedilol	decreases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:C043211	Carvedilol results in decreased expression of FASLG	PMID:12875697
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:136185	VX nerve agent	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C009680	VX results in decreased activity of BCHE protein	PMID:16915560
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:17941	diisopropyl fluorophosphate	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D007531	Isoflurophate results in decreased activity of BCHE protein	PMID:4631366
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:196010	Butyrylcholine	increases hydrolysis	EXP		E	RGD:6480464	20231003	CTD	MESH:C017100	BCHE protein results in increased hydrolysis of butyrylcholine	PMID:4631366|PMID:4985882
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:196010	Butyrylcholine	multiple interactions	EXP		E	RGD:6480464	20231003	CTD	MESH:C017100	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	PMID:4985882
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:27827	paraoxon	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D010261	Paraoxon results in decreased activity of BCHE protein	PMID:4631366
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:30336	phosphoryl trichloride	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:C013196	phosphoryl chloride results in decreased activity of BCHE protein	PMID:12641435
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:34690	dichlorvos	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D004006	Dichlorvos results in decreased activity of BCHE protein	PMID:3627083|PMID:4631366
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:41055	butyrylthiocholine	increases hydrolysis	EXP		E	RGD:6480464	20191114	CTD	MESH:D002092	BCHE protein results in increased hydrolysis of Butyrylthiocholine	PMID:22407886
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:45652	succinylcholine	increases hydrolysis	EXP		E	RGD:6480464	20191114	CTD	MESH:D013390	BCHE protein results in increased hydrolysis of Succinylcholine	PMID:4985882
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:45652	succinylcholine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013390	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	PMID:4985882
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:75701	sarin	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D012524	Sarin results in decreased activity of BCHE protein	PMID:16915560
12425628	BCHE	butyrylcholinesterase	gene	CHEBI:9195	Soman	decreases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D012999	Soman results in decreased activity of BCHE protein	PMID:16915560
12427628	AP2M1	adaptor related protein complex 2 subunit mu 1	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of AP2M1 mRNA	PMID:27255383
12428468	UGDH	UDP-glucose 6-dehydrogenase	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D010634	Phenobarbital results in increased expression of UGDH protein	PMID:19952500
12429250	CYP1A1	cytochrome P450 family 1 subfamily A member 1	gene	CHEBI:28119	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D013749	[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein	PMID:24389113
12429250	CYP1A1	cytochrome P450 family 1 subfamily A member 1	gene	CHEBI:28909	iprodione	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C033148	[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein	PMID:24389113
12429250	CYP1A1	cytochrome P450 family 1 subfamily A member 1	gene	CHEBI:63933	Aroclor 1254	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:D020111	[Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein	PMID:24389113
12429250	CYP1A1	cytochrome P450 family 1 subfamily A member 1	gene	CHEBI:77013	beta-naphthoflavone	increases activity	EXP		E	RGD:6480464	20191114	CTD	MESH:D019324	beta-Naphthoflavone results in increased activity of CYP1A1 protein	PMID:3929785
12429250	CYP1A1	cytochrome P450 family 1 subfamily A member 1	gene	CHEBI:8434	prochloraz	multiple interactions	EXP		E	RGD:6480464	20191114	CTD	MESH:C045362	[prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein	PMID:24389113
12429909	VPS35	VPS35 retromer complex component	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of VPS35 mRNA	PMID:27255383
12433672	TCP1	t-complex 1	gene	CHEBI:63450	masitinib	decreases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in decreased expression of TCP1 protein	PMID:22747577
12436414	HSPD1	heat shock protein family D (Hsp60) member 1	gene	CHEBI:17775	7,9-dihydro-1H-purine-2,6,8(3H)-trione	decreases expression	EXP		E	RGD:6480464	20210309	CTD	MESH:D014527	Uric Acid results in decreased expression of HSPD1 protein	PMID:32991862
12436414	HSPD1	heat shock protein family D (Hsp60) member 1	gene	CHEBI:3750	clofibrate	increases expression	EXP		E	RGD:6480464	20191114	CTD	MESH:D002994	Clofibrate results in increased expression of HSPD1 protein	PMID:19952500
12436542	SNX7	sorting nexin 7	gene	CHEBI:197437	mocetinostat	increases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in increased expression of SNX7 mRNA	PMID:27255383
13395345	ADRA1D	adrenoceptor alpha 1D	gene	CHEBI:31891	Naftopidil	multiple interactions	EXP		E	RGD:6480464	20210114	CTD	MESH:C064357	naftopidil binds to and results in decreased activity of ADRA1D protein; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]	PMID:19371927
13395345	ADRA1D	adrenoceptor alpha 1D	gene	CHEBI:8093	phenylephrine	multiple interactions	EXP		E	RGD:6480464	20210114	CTD	MESH:D010656	BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; Phenylephrine binds to and results in increased activity of ADRA1D protein	PMID:19371927
40911580	SCT	secretin	gene	CHEBI:16684	atropine	multiple interactions	EXP		E	RGD:6480464	20210119	CTD	MESH:D001285	Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]	PMID:3562434
40911580	SCT	secretin	gene	CHEBI:17544	hydrogencarbonate	increases abundance	EXP		E	RGD:6480464	20210119	CTD	MESH:D001639	SCT protein results in increased abundance of Bicarbonates	PMID:3562434
40911580	SCT	secretin	gene	CHEBI:17544	hydrogencarbonate	multiple interactions	EXP		E	RGD:6480464	20210119	CTD	MESH:D001639	[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates; Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]	PMID:3562434
40911580	SCT	secretin	gene	CHEBI:28358	rac-lactic acid	decreases abundance	EXP		E	RGD:6480464	20210119	CTD	MESH:D019344	SCT protein results in decreased abundance of Lactic Acid	PMID:2418308
40911580	SCT	secretin	gene	CHEBI:59219	ceruletide	multiple interactions	EXP		E	RGD:6480464	20210119	CTD	MESH:D002108	[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates	PMID:3562434
40911580	SCT	secretin	gene	CHEBI:78320	2-hydroxypropanoic acid	decreases abundance	EXP		E	RGD:6480464	20210119	CTD	MESH:D019344	SCT protein results in decreased abundance of Lactic Acid	PMID:2418308
40911580	SCT	secretin	gene	CHEBI:78734	tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate	multiple interactions	EXP		E	RGD:6480464	20210119	CTD	MESH:D001285	Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]	PMID:3562434
40919152	SRR	serine racemase	gene	CHEBI:63450	masitinib	increases expression	EXP		E	RGD:6480464	20210608	CTD	MESH:C526575	masitinib results in increased expression of SRR mRNA	PMID:22747577
40924379	STAM2	signal transducing adaptor molecule 2	gene	CHEBI:197437	mocetinostat	decreases expression	EXP		E	RGD:6480464	20231107	CTD	MESH:C523184	mocetinostat results in decreased expression of STAM2 mRNA	PMID:27255383