# RGD-PIPELINE: ftp-file-extracts
# MODULE: annotations-version-1.1.9 (Oct 10, 2019)
# GENERATED-ON: 2025/01/25
# PURPOSE: annotations about active Green Monkey objects extracted from RGD database
# ONTOLOGY: ChEBI: ChEBI Ontology
# CONTACT: rgd.data@mcw.edu
# FORMAT: tab delimited text
# NOTES: multiple values in a single column are separated by '|'
#
#COLUMN INFORMATION:
#
#1   RGD_ID	          unique RGD_ID of the annotated object
#2   OBJECT_SYMBOL      official symbol of the annotated object
#3   OBJECT_NAME        official name of the annotated object
#4   OBJECT_TYPE        annotated object data type: one of ['gene','qtl','strain']
#5   TERM_ACC_ID        ontology term accession id
#6   TERM_NAME          ontology term name
#7   QUALIFIER          optional qualifier
#8   EVIDENCE           evidence
#9   WITH               with info
#10  ASPECT             aspect
#11  REFERENCES         db references (Reference RGDID|PUBMED ID)
#12  CREATED_DATE       created date
#13  ASSIGNED_BY        assigned by
#14  MESH_OMIM_ID       MESH:xxx or OMIM:xxx id corresponding to RDO:xxx id found in TERM_ACC_ID column (RGD/CTD Disease Ontology annotations only)
#15  CURATION_NOTES     curation notes provided by RGD curators
#16  ORIGINAL_REFERENCE original reference
RGD_ID	OBJECT_SYMBOL	OBJECT_NAME	OBJECT_TYPE	TERM_ACC_ID	TERM_NAME	QUALIFIER	EVIDENCE	WITH	ASPECT	REFERENCES	CREATED_DATE	ASSIGNED_BY	MESH_OMIM_ID	CURATION_NOTES	ORIGINAL_REFERENCE
18621458	SOD3	superoxide dismutase 3	gene	CHEBI:35696	cobalt dichloride	decreases expression	EXP		E	RGD:6480464	20210615	CTD	MESH:C018021	cobaltous chloride results in decreased expression of SOD3 mRNA; cobaltous chloride results in decreased expression of SOD3 protein	PMID:19031313
18621458	SOD3	superoxide dismutase 3	gene	CHEBI:35696	cobalt dichloride	multiple interactions	EXP		E	RGD:6480464	20210615	CTD	MESH:C018021	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	PMID:19031313
18621458	SOD3	superoxide dismutase 3	gene	CHEBI:90705	SB 203580	multiple interactions	EXP		E	RGD:6480464	20210615	CTD	MESH:C093642	SB 203580 inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]	PMID:19031313
18694696	CYP2B6	cytochrome P450 family 2 subfamily B member 6	gene	CHEBI:16236	ethanol	multiple interactions	EXP		E	RGD:6480464	20210615	CTD	MESH:D000431	[Nicotine co-treated with Ethanol] results in increased expression of CYP2B6 protein	PMID:22935730
18694696	CYP2B6	cytochrome P450 family 2 subfamily B member 6	gene	CHEBI:17688	(S)-nicotine	increases expression	EXP		E	RGD:6480464	20210615	CTD	MESH:D009538	Nicotine results in increased expression of CYP2B6 protein	PMID:22935730
18694696	CYP2B6	cytochrome P450 family 2 subfamily B member 6	gene	CHEBI:17688	(S)-nicotine	multiple interactions	EXP		E	RGD:6480464	20210615	CTD	MESH:D009538	[Nicotine co-treated with Ethanol] results in increased expression of CYP2B6 protein	PMID:22935730
18694696	CYP2B6	cytochrome P450 family 2 subfamily B member 6	gene	CHEBI:18723	nicotine	increases expression	EXP		E	RGD:6480464	20210615	CTD	MESH:D009538	Nicotine results in increased expression of CYP2B6 protein	PMID:22935730
18694696	CYP2B6	cytochrome P450 family 2 subfamily B member 6	gene	CHEBI:18723	nicotine	multiple interactions	EXP		E	RGD:6480464	20210615	CTD	MESH:D009538	[Nicotine co-treated with Ethanol] results in increased expression of CYP2B6 protein	PMID:22935730
18694696	CYP2B6	cytochrome P450 family 2 subfamily B member 6	gene	CHEBI:8069	phenobarbital	increases expression	EXP		E	RGD:6480464	20210615	CTD	MESH:D010634	Phenobarbital results in increased expression of CYP2B6 mRNA	PMID:22935730