QTL_RGD_ID SPECIES QTL_SYMBOL QTL_NAME CHROMOSOME_FROM_REF LOD P_VALUE VARIANCE FLANK_1_RGD_ID FLANK_1_SYMBOL FLANK_2_RGD_ID FLANK_2_SYMBOL PEAK_RGD_ID PEAK_MARKER_SYMBOL TRAIT_NAME SUBTRAIT_NAME TRAIT_METHODOLOGY PHENOTYPES ASSOCIATED_DISEASES CURATED_REF_RGD_ID CURATED_REF_PUBMED_ID CANDIDATE_GENE_RGD_IDS CANDIDATE_GENE_SYMBOLS INHERITANCE_TYPE RELATED_QTLS RATMAP_ID 3.4_MAP_POS_CHR 3.4_MAP_POS_START 3.4_MAP_POS_STOP 3.4_MAP_POS_METHOD 3.1_MAP_POS_CHR 3.1_MAP_POS_START 3.1_MAP_POS_STOP 3.1_MAP_POS_METHOD STRAIN_RGD_IDS STRAIN_RGD_SYMBOLS CROSS_TYPE CROSS_PAIR
61324 rat Eae5 Experimental allergic encephalomyelitis QTL 5 12 13.0 11051 D12Mit2 34925 D12Rat9 Brain/spinal cord inflammation relapsing disease inflammation severity was assayed daily following injection with DA rat spinal cord homogenate with rats scored for degree of tail and limb paralysis on a nine point scale; relapsing disease is defined as more than one period of three-day increase in clinical score paresis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 61031 10640775 Pia 4 44536 12 20932559 24470522 1 - by flanking markers 12 20922171 24333738 1 - by flanking markers 60997;61013 DA;E3 F2 E3 x DA
61325 rat Aia5 Adjuvant induced arthritis QTL 5 10 0.01 61274 D10Arb20 61275 D10Arb22 10466 D10Mit1 Joint/bone inflammation adjuvant induced arthritis severity after adjuvant injection was measured via a cumulative scoring system for multiple joints; animals were evaluated twice a week for six weeks joint swelling Arthritis, Rheumatoid 625379 11953987 Cia3 and Pia5; reported to be the same as Aia3;Cia5 45641 10 24006429 110718848 2 - by one flank and peak markers 10 24007478 110733352 2 - by one flank and peak markers 61095;61114;631282 DA.F344(Cia5);DA/Bkl;DA.F344-(D10Rat37-D10Arb22) Congenic DA.F344 Congenic
61326 rat Eae6 Experimental allergic encephalomyelitis QTL 6 1 5.3 34399 D1Mgh9 10951 D1Mit13 34326 D1Mgh21 Brain/spinal cord inflammation change in body weight experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; change in body weight from day 7 to 40 was determined in association with disease status paresis Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 61031;629561 10640775;11817600 44537 1 176854992 217991764 2 - by one flank and peak markers 1 176994239 186621913 1 - by flanking markers 60997;61013 DA;E3 F2 E3xDA;E3 x DA
61327 rat Eae7 Experimental allergic encephalomyelitis QTL 7 1 5.6 33903 D1Mit7 10674 D1Mgh12 10445 D1Wox25 Brain/spinal cord inflammation change in body weight inflammation severity was assayed daily following injection with DA rat spinal cord homogenate with animals scored for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; change in body weight from day 7 to 40 was determined in association with disease status paresis Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 61031;61039;629561 10640775;7537756;11817600 44538 1 240980142 247322277 1 - by flanking markers 1 241163531 247436752 1 - by flanking markers 60997;61013 DA;E3 F2 E3xDA;E3 x DA
61328 rat Eae8 Experimental allergic encephalomyelitis QTL 8 19 4.0 11471 D19Mit9 34033 D19Mit5 Brain/spinal cord inflammation acute disease experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; acute disease is defined as a monophasic disease pattern in the assay over time paresis Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 61031 10640775 44539 19 26534810 34998604 1 - by flanking markers 19 26539634 35003485 1 - by flanking markers 60997;61013 DA;E3 F2 E3 x DA
61329 rat Eae9 Experimental allergic encephalomyelitis QTL 9 6 3.7 34098 D6Mgh3 35821 D6Rat10 Brain/spinal cord inflammation change in body weight inflammation severity was assayed daily following injection with DA rat spinal cord homogenate with animals scored for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; change in body weight from day 7 to 40 was determined in association with disease status paresis Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 61031 10640775 44540 6 127683728 147636619 4 - by one flank marker only 6 127687475 147642806 4 - by one flank marker only 60997;61013 DA;E3 F2 E3 x DA
61330 rat Eau1 Experimental allergic uveoretinitis QTL 1 4 3.0E-4 11173 D4Arb8 34001 D4Mit17 11013 D4Arb7 Uvea inflammation score abnormal uvea morphology;eye inflammation Uveitis 2293749;2296064;61073 18281616;18453595;10323205 3197;3834 Npy;Tcrb Cia3, Aia3, Iddm/Lyp, Scwia1 45703 4 69183301 134858710 1 - by flanking markers 4 69459431 135103551 1 - by flanking markers 60999;70509 LEW;F344/N F2 LEWxF344
61331 rat Eau2 Experimental allergic uveoretinitis QTL 2 12 5.0E-4 41960 D12Arb2 61278 D12Arb5 41960 D12Arb2 Uvea inflammation score abnormal uvea morphology;eye inflammation Uveitis 2293749;2296064;61073 18281616;18453595;10323205 Cia12, Pia4 45704 12 1 29130348 4 - by one flank marker only 12 0 28993736 4 - by one flank marker only 60999;70509 LEW;F344/N F2 LEWxF344
61332 rat Eau3 Experimental allergic uveoretinitis QTL 3 10 0.004 61279 D10Arb3 33941 D10Mit11 34053 D10Mit3 Uvea inflammation score abnormal uvea morphology;eye inflammation Uveitis 2293749;2296064;61073 18281616;18453595;10323205 2836;3395;3645;3772;3773;3774;3877;3967;61276;69069;1594396 Hsd17b1;Prkca;Ccl2;Stat3;Stat5a;Stat5b;Tnfaip1;Vtn;Crhr1;Ccl5;Trim25 Cia5, Oia3, Carrageenan, Pia10, Aia5, Atps2 10 35713452 101848683 1 - by flanking markers 10 35714501 101863126 1 - by flanking markers 60999;70509 LEW;F344/N F2 LEWxF344
61428 rat Scl3 Serum cholesterol level QTL 3 7 3.2 14.0 38334 D7Rat77 36442 D7Rat20 33729 D7Mit10 Lipid level cholesterol decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 45714 7 95054656 132141292 1 - by flanking markers 7 95088886 132217729 1 - by flanking markers 61103;61116 WKY;SHRSP/A3 F2 SHRSP/A3 x WKY
61429 rat Cia17 Collagen induced arthritis QTL 17 18 4.6 10689 D18Mit5 41356 D18Rat82 41356 D18Rat82 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61067 18540828;18606636;16804090;11001927 45684 18 51166414 87265094 3 - by peak only 18 32494084 73739829 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61431 rat Cia19 Collagen induced arthritis QTL 19 X 4.4 34192 DXMgh9 43947 DXWox3 34991 DXRat66 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61067 18540828;18606636;16804090;11001927 Cia18, Iddm 45686 X 1 88514313 2 - by one flank and peak markers X 0 88587746 2 - by one flank and peak markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61432 rat Cia1 Collagen induced arthritis QTL 1 20 11428 D20Wox3 40318 D20Rat60 11428 D20Wox3 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61062 18606636;16804090;18540828;8782824 32927 20 1 14605852 4 - by one flank marker only 20 3660872 14612758 1 - by flanking markers 61109;61114 F344/NHsd;DA/Bkl F2 DA/Bkl x F344/NHsd
61434 rat Cia3 Collagen induced arthritis QTL 3 4 4.8 10562 D4Arb21 61302 D4Arb24 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint inflammation;joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61062;61068 18606636;16804090;18540828;8782824;9692888 Aia3, Pia5;Pia5 32929 4 104415843 149415843 4 - by one flank marker only 4 104660324 149660324 4 - by one flank marker only 61109;61114 F344/NHsd;DA/Bkl F2 DA/Bkl x F344/NHsd
61435 rat Cia4 Collagen induced arthritis QTL 4 7 5.3 10221 D7Arb17 34999 D7Rat44 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint inflammation;joint swelling Arthritis, Rheumatoid;Arthritis, Rheumatoid 1599708;2300074;1582387;2307198;61069;61062;61068 17277140;18606636;16804090;18540828;10398805;8782824;9692888 2896;3285 Il2rb;Pdgfrb recessive Cia8 32930 7 21202126 66202126 4 - by one flank marker only 7 21222856 66222856 4 - by one flank marker only 61109;61114 F344/NHsd;DA/Bkl F2 DA/Bkl x F344/NHsd
61436 rat Cia5 Collagen induced arthritis QTL 5 10 4.9 2686 Gh1 61275 D10Arb22 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint swelling;joint inflammation Arthritis, Rheumatoid 1642451;2300074;1582387;61062;61068 17673937;18606636;16804090;8782824;9692888 3395;61312 Prkca;Timp2 Cia20, Cia21, Cia22, Cia23, Aia5;Aia5 32931 10 95692240 110718848 4 - by one flank marker only 10 95708476 110733352 4 - by one flank marker only 61109;61114 F344/NHsd;DA/Bkl F2 DA/Bkl x F344/NHsd
61437 rat Cia6 Collagen induced arthritis QTL 6 8 34310 D8Mgh4 38898 D8Rat71 34068 D8Mgh11 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 1599708;2307198;2300074;1582387;61067 17277140;18540828;18606636;16804090;11001927 45674 8 86627869 127907359 1 - by flanking markers 8 86647325 127927002 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61438 rat Cia7 Collagen induced arthritis QTL 7 2 4.6 1.0E-4 20.0 11156 D2Mit24 33983 D2Mit23 33674 D2Mit17 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint inflammation;joint swelling Arthritis, Rheumatoid;Arthritis, Rheumatoid 2307198;2300074;1582387;61067;61063 18540828;18606636;16804090;11001927;9870869 2391 Cpb1 dominant 45675 2 59700886 146659672 1 - by flanking markers 2 59629119 146609712 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61439 rat Cia8 Collagen induced arthritis QTL 8 7 5.1 36422 D7Rat26 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2307198;61069 18540828;10398805 44497 61109;61114 F344/NHsd;DA/Bkl F2 DA/Bkl x F344/NHsd
61440 rat Cia9 Collagen induced arthritis QTL 9 Y Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint inflammation;joint swelling Arthritis, Rheumatoid 61064;61065;61063 10331011;10631556;9870869 45676 10000;61114 ACI/N;DA/Bkl F2 DA/Bkl x ACI
61441 rat Btemp1 Thermal response to stress QTL 1 10 4.0 52.0 33846 D10Mit2 33909 D10Mit4 3138 Myh3 Body temperature under stress increased body temperature Body Temperature Changes 61094 10679499 45718 10 36650094 64860949 1 - by flanking markers 10 36651253 64874572 1 - by flanking markers 61100;61117 SHR/Ola;BN-Lx/Cub SHR/Ola x BN-lx/Cub
61442 rat Strs1 Sensitivity to stroke QTL 1 1 7.4 33959 D1Mit3 Stroke susceptibility latency until stroke CNS ischemia Cerebrovascular Accident 2307158;61093 16835352;8696337 39099 1 124471914 169471914 3 - by peak only 1 124550321 169550321 3 - by peak only 61000;61010 SHR;SHRSP F2 SHRSP x SHR
61443 rat Btemp2 Thermal response to stress QTL 2 12 3.3 61306 Hspb1 33725 D12Mit1 3019 Lsn2_mapped Body temperature under stress increased body temperature Body Temperature Changes 61094 10679499 45719 12 15508819 21911223 1 - by flanking markers 12 15538810 21898486 1 - by flanking markers 61100;61117 SHR/Ola;BN-Lx/Cub SHR/Ola x BN-lx/Cub
61444 rat Strs2 Sensitivity to stroke QTL 2 5 4.7 3193 Nppa Stroke susceptibility latency until stroke CNS ischemia Cerebrovascular Accident 61093 8696337 39100 5 142575172 173096209 3 - by peak only 5 142585356 173106704 3 - by peak only 61000;61010 SHR;SHRSP F2 SHRSP x SHR
61445 rat Strs3 Sensitivity to stroke QTL 3 4 3.0 10144 D4Mgh16 Stroke susceptibility latency until stroke CNS ischemia Cerebrovascular Accident 61093 8696337 39101 4 39146794 84146794 3 - by peak only 4 39422924 84422924 3 - by peak only 61000;61010 SHR;SHRSP F2 SHRSP x SHR
61446 rat Coreg2 Compensatory renal growth QTL 2 4 3.5 54.0 3371 Pparg 2554 Eno2 61315 D4Cebr7s17 Renal growth compensatory increased compensatory renal growth Kidney Diseases 61071 10864582 2245 Cacna1c 4 151492220 160897723 1 - by flanking markers 4 151796047 161144004 1 - by flanking markers 61100;61117 SHR/Ola;BN-Lx/Cub F2 SHR/Ola x BN-lx/Cub
61447 rat Tcas1 Tongue tumor susceptibility QTL 1 19 6.08 11471 D19Mit9 Tongue tumor susceptibility abnormal Deiters cell morphology Tongue Neoplasms 61091 9563479 2503 Nqo1 44501 19 4034890 49034890 3 - by peak only 19 4039715 49039715 3 - by peak only 61007;61111 WF;DA/Slc F1 DA/Slc x WF
61448 rat Ciaa1 CIA Autoantibody QTL 1 20 30.0 0.001 11206 D20Arb2 61316 D20Arb8 11428 D20Wox3 Anti-type II collagen autoantibody titer collagen induced levels of IgG antibody titers for type II collagen were determined from serum samples 28 days after collagen injection joint inflammation;increased IgG level Arthritis, Rheumatoid;Arthritis, Rheumatoid 2307198;2300074;1582387;61066;61067;61062 18540828;18606636;16804090;10857786;11001927;8782824 appears to overlap with Cia1, Aia1, and Oia1 on chr 20 32932 20 2790738 4531120 2 - by one flank and peak markers 60985;60997 BN;DA F2 DAxF344, DAxBN, BB/DRxBN
61449 rat Ciaa2 CIA Autoantibody QTL 2 10 7.1 10142 D10Arb9 10641 D10Wox22 10642 D10Mit12 Anti-type II collagen autoantibody titer collagen induced levels of IgG antibody titers for type II collagen were determined from serum samples 28 days after collagen injection joint inflammation;increased IgG level Arthritis, Rheumatoid;Arthritis, Rheumatoid 2300074;1582387;2307198;61066 18606636;16804090;18540828;10857786 2836;3773;3774;3877;1594396 Hsd17b1;Stat5a;Stat5b;Tnfaip1;Trim25 Aia5, Eau3, Carrageenan, Atps2, Pia10, Cia5, Cia5b [this needs to be fixed!!] 32933 10 64308668 95695218 1 - by flanking markers 10 64322291 109322291 4 - by one flank marker only 60997;70509 DA;F344/N F2 DAxF344
61450 rat Ciaa3 CIA Autoantibody QTL 3 9 6.5 44567 D9Wox19 60827 D9Wox23 60827 D9Wox23 Anti-type II collagen autoantibody titer collagen induced levels of IgG antibody titers for type II collagen were determined from serum samples 28 days after collagen injection joint inflammation;increased IgG level Arthritis, Rheumatoid 2300074;1582387;2307198;61066;61067 18606636;16804090;18540828;10857786;11001927 2232;3951 C3;Vav1 recessive Cia15 45689 9 18347567 63347567 4 - by one flank marker only 9 18344890 63344890 4 - by one flank marker only 60985;60997 BN;DA F2;intercross DAxBN, BB/DRxBN
61451 rat Ciaa4 CIA Autoantibody QTL 4 4 3.1 34256 D4Mgh18 34338 D4Mgh11 33768 D4Mit14 Anti-type II collagen autoantibody titer increased IgG level Arthritis, Rheumatoid 2307198;2300074;1582387;61067 18540828;18606636;16804090;11001927 2306;61318;61319;61320;621237 Cd4;Cd69;Tnfrsf7;Kird1;Tnfrsf1a Cia13, Oia2 45690 4 128179957 171204531 1 - by flanking markers 4 128424798 171449467 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61452 rat Ciaa5 CIA Autoantibody QTL 5 5 3.5 43928 D5Wox3 34443 D5Mgh8 34220 D5Mgh13 Anti-type II collagen autoantibody titer increased IgG level Arthritis, Rheumatoid 2307198;2300074;1582387;61067 18540828;18606636;16804090;11001927 2943 Jun 45691 5 99080786 149757440 1 - by flanking markers 5 99086012 149767479 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61453 rat Pur1 Proteinuria QTL 1 13 18.06 34371 D13Mgh3 34351 D13Mgh4 Renal function urine protein level urine albumin level, urine protein level, focal glomerulosclerosis, and indirect systolic blood pressure were measured 8 weeks after unilateral nephrectomy proteinuria Proteinuria 2292230;619599 18064521;9799838 45094 13 1 38489943 4 - by one flank marker only 13 0 38503986 4 - by one flank marker only 61118;61119 BUF/Mna;WKY/NCrlCrlj (BUF/Mna x WKY/NCrj) x BUF/Mna backcross BUF/Mna x WKY/NCrj
61455 rat Niddm7 Non-insulin dependent diabetes mellitus QTL 7 1 5.5 16.0 43424 D1Wox10 2470 Cyp2c12 43424 D1Wox10 Glucose level intravenous glucose tolerance and insulin secretion tests (IVGTT) were performed in 16 week old rats impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 61061 8528248 2870;3786 Igf2;Abcc8 34222 1 198139596 243139596 3 - by peak only 1 198303619 243303619 3 - by peak only 10017;60985 GK/KyoSwe;BN F2;intercross GK x BN;GKxBN
61457 rat Niddm8 Non-insulin dependent diabetes mellitus QTL 8 2 4.1 0.01 12.0 3336 Pklr 3195 Npr1 11048 D2Wox23 Insulin level fasting intravenous insulin secretion tests were performed in 16 week old rats and arginine induced insulin secretion was measured at 24 weeks of age increased circulating insulin level Diabetes Mellitus, Non-Insulin-Dependent 2313613;61061 19575795;8528248 34223 2 181214853 182740242 1 - by flanking markers 2 181164961 182690348 1 - by flanking markers 10017;60985 GK/KyoSwe;BN F2 GK x BN;GKxBN
61458 rat Bp10 Blood pressure QTL 10 2 3.42 2167 Atp1a1 2263 Camk2d 2167 Atp1a1 Blood pressure salt-loaded blood pressure measured by tail-cuff in F2 males maintained on high salt diet increased systemic arterial blood pressure Hypertension 61037;61038;619639 1363813;8040284;7768551 3195 Npr1 Bp14,Bp16,Bp19,Bp36 34599 2 196657749 224108082 1 - by flanking markers 2 196620502 224097854 1 - by flanking markers 61103 WKY F2 SS/JrxWKY
61461 rat Bp11 Blood pressure QTL 11 13 Blood pressure increased systemic arterial blood pressure Hypertension 61037 1363813 Bp5, Bp24, Bp 25, Bp31 34600 60992;61103 MNS;WKY F2
61462 rat Niddm10 Non-insulin dependent diabetes mellitus QTL 10 5 3.9 0.001 11.0 43870 D5Wox8 60809 D5Wox7 Glucose level intravenous glucose tolerance and insulin secretion tests (IVGTT) were performed in 16 week old rats impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 61061 8528248 34225 5 1 4291301 4 - by one flank marker only 5 0 4291301 4 - by one flank marker only 10017;60985 GK/KyoSwe;BN F2;intercross GK x BN;GKxBN
61464 rat Niddm11 Non-insulin dependent diabetes mellitus QTL 11 8 3.1 0.001 10.0 10168 D8Wox5 Insulin level intravenous glucose tolerance and insulin secretion tests (IVGTT) were performed in 16 week old rats increased circulating insulin level Diabetes Mellitus, Non-Insulin-Dependent 61061 8528248 34226 10017;60985 GK/KyoSwe;BN intercross;F2 GKxBN;GK x BN
61465 rat Bp13 Blood pressure QTL 13 2 3.3 33620 D2Mit6 2391 Cpb1 33620 D2Mit6 Blood pressure increased systemic arterial blood pressure Hypertension 61041 8901842 Bp6 34966 2 60443909 105443909 4 - by one flank marker only 2 77561812 105388871 1 - by flanking markers 61010;61103 SHRSP;WKY F2;backcross SHRSP x WKY
61467 rat Bp14 Blood pressure QTL 14 2 3.1 34461 D2Mgh12 34278 D2Mgh14 Blood pressure increased systemic arterial blood pressure Hypertension 1643008;61041;631154 17938382;8901842;12624007 Bp10, Bp16, Bp19, Bp166 34967 2 42866342 210636008 1 - by flanking markers 61010;61103 SHRSP;WKY F2;backcross SHRSP x WKY
61468 rat Bp15 Blood pressure QTL 15 3 4.4 34347 D3Mgh16 Blood pressure salt loaded systolic blood pressure measured in F2 males increased systemic arterial blood pressure Hypertension 61041 8901842 recessive 34969 3 1 28873394 3 - by peak only 3 0 28873695 3 - by peak only 61010;61103 SHRSP;WKY F2 SHRSP x WKY
61470 rat Bp17 Blood pressure QTL 17 2 8.0E-4 33618 D19Mit7 61323 D2N35 61321 D2Nih4 Blood pressure increased systemic arterial blood pressure Hypertension 61044 7560090 36655 19 45090802 59218465 4 - by one flank marker only 19 45095501 59223525 4 - by one flank marker only 61098;61099 BXH;HXB F2 SHRxBN
61471 rat Bp18 Blood pressure QTL 18 2 3.0 3119 Mt1-ps2 34278 D2Mgh14 Blood pressure salt-loaded systolic increased systemic arterial blood pressure Hypertension 61045 9132270 36643 60985;61000 BN;SHR F2 SHRxBN
61473 rat Bp19 Blood pressure QTL 19 2 6.3 34292 D2Mgh8 3195 Npr1 Blood pressure salt-loaded systolic increased systemic arterial blood pressure Hypertension 61045 9132270 Bp10, Bp14, Bp16, Bp19 36644 2 179302449 182740242 1 - by flanking markers 2 179252555 182690348 1 - by flanking markers 60985;61000 BN;SHR F2 SHRxBN
61474 rat Eae1 Experimental allergic encephalomyelitis QTL 1 20 3.0 37594 D20Rat41 34280 D20Mgh4 Brain/spinal cord inflammation severity of disease paresis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 61031 10640775 Pia 1 44535 20 4740609 6880471 1 - by flanking markers 20 4740837 6880698 1 - by flanking markers 60997;61013 DA;E3 F2 E3 x DA
61476 rat Aia3 Adjuvant induced arthritis QTL 3 4 3.9 42168 D4Arb30 10158 D4Arb16 61302 D4Arb24 Joint/bone inflammation adjuvant induced joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61035;629560 18606636;16804090;18540828;9780220;12571866 3197;3834 Npy;Tcrb Cia3;Pia5;Cia3, Aia3, and Pia5 45639 4 73972453 133939659 1 - by flanking markers 4 74248583 119248583 4 - by one flank marker only 60997;70509 DA;F344/N F2 DAxF344
61477 rat Aia4 Adjuvant induced arthritis QTL 4 15 3.0 33820 D15Mit6 34471 D15Mgh3 35230 D15Rat22 Joint/bone inflammation adjuvant induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61035 18540828;18606636;16804090;9780220 45640 15 61458810 99039586 1 - by flanking markers 15 61474590 99055325 1 - by flanking markers 60997;70509 DA;F344/N F2 DAxF344
61337 rat Bp22 Blood pressure QTL 22 8 5.1 33559 D8Mit5 33887 D8Mit3 Blood pressure salt-loaded systolic systolic, diastolic, mean blood pressures and heart rate measured directly through a femoral catheter inserted in rats following treatment for 13 days with a diet including water with 1% NaCl increased systemic arterial blood pressure Hypertension 61045 9132270 Bp35, Bp39 36647 8 32203394 45291808 1 - by flanking markers 8 32212161 45300574 1 - by flanking markers 60985;61000 BN;SHR intercross;F2 SHRxBN;SHR x BN
61338 rat Bp23 Blood pressure QTL 23 16 4.3 33848 D16Mit2 33652 D16Mit5 Blood pressure salt-loaded systolic systolic, diastolic, mean blood pressures and heart rate measured directly through a femoral catheter inserted in rats following treatment for 13 days with a diet including water with 1% NaCl increased systemic arterial blood pressure Hypertension 61045 9132270 36648 16 4304396 49304396 4 - by one flank marker only 16 4304394 49304394 4 - by one flank marker only 60985;61000 BN;SHR intercross;F2 SHRxBN;SHR x BN
61339 rat Bp24 Blood pressure QTL 24 13 0.05 33923 D13Mit1 3554 Ren Blood pressure increased systemic arterial blood pressure Hypertension 61046 8567976 Bp5, Bp11, Bp25, Bp31 36649 13 25430110 46275213 1 - by flanking markers 10040;10041;628909 SR/Jr;SS/Jr;SHR.BN-(D13Arb5-Ren1)/Ipcv F2
61340 rat Bp25 Blood pressure QTL 25 13 4.2 0.004 34371 D13Mgh3 61281 D13M1Mit108 Blood pressure salt-loaded systolic systolic blood pressure measured by tail cuff method in rats that were fed a diet containing 8% NaCl for 8 weeks increased systemic arterial blood pressure Hypertension 61047 9271663 related to (Bpdsr106--place holder for new QTL number to be substituted here) Both QTLs from same paper, Bp25 contains mapping data from (SS/Jr X SR/Jr) F2 and Bpdsr106 describes the QTL defined by related congenic strains derived in the same reference 36650 10040;10041 SR/Jr;SS/Jr F2 SS/Jr x SR/Jr
61341 rat Bp26 Blood pressure QTL 26 1 33959 D1Mit3 2870 Igf2 Blood pressure increased systemic arterial blood pressure Hypertension 61048 9336384 Bpfh1, Bp28, Bp29, Bp30 36651 1 146971846 202915231 1 - by flanking markers 1 147050253 203103297 1 - by flanking markers 61100;737972 SHR/Ola;BN/Crl F2
61342 rat Bp27 Blood pressure QTL 27 1 3.4 61282 D1M7Mit69 61283 D1Mco2 61284 D1Mco1 Blood pressure salt-loaded systolic systolic blood pressure measured by tail cuff method in rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61049;61040 8609235;9685318 36653 10041;60999 SS/Jr;LEW F2
61343 rat Bp28 Blood pressure QTL 28 1 62086 Acsm3 Blood pressure systolic increased systemic arterial blood pressure Hypertension 61050 8094726 Bpfh1, Bp26, Bp29, Bp30 36652 1 155568068 200568068 3 - by peak only 1 155713163 200713163 3 - by peak only 61010;61103 SHRSP;WKY F2 SHRSP x WKY
61345 rat Rf1 Renal disease susceptibility QTL 1 1 16.9 33571 D1Mit6 10674 D1Mgh12 Renal function urine albumin level proteinuria;glomerulosclerosis Kidney Failure, Chronic 1299961;1359045;625641;1643000;61060;61090;1582571 15060005;15976509;11875190;17413446;8528250;7704027;16837819 2721;3780;69193;69327;70931;620485;620716;621077;621325;621578;621721 Got1;Slk;Hps1;Arl3;Cpn1;Pi4k2a;Sfxn3;Mgea5;As3mt;Nolc1;Avpi1 34362 1 202322277 247322277 4 - by one flank marker only 1 202436752 247436752 4 - by one flank marker only 10000;60993;628372 ACI/N;FHH;ACI.FHH-(D1Mit34-D1Rat156) (FHH x ACI) x FHH Backcross ACIxFHH;FHH x ACI
61346 rat Rf2 Renal disease susceptibility QTL 2 1 3.7 34011 D1Mit2 33959 D1Mit3 Renal function urine albumin level proteinuria;glomerulosclerosis Kidney Failure, Chronic 1357409;61060;61090 15758045;8528250;7704027 34363 1 134980526 146971983 1 - by flanking markers 1 135058870 147050389 1 - by flanking markers 10000;60993;1357959 ACI/N;FHH;FHH.BN-(Rab38)/Mcwi (FHH x ACI) x FHH Backcross ACIxFHH;FHH x ACI
61348 rat Bp30 Blood pressure QTL 30 1 2.4 2870 Igf2 61285 D1Nih1 62086 Acsm3 Blood pressure salt-loaded systolic systolic blood pressure measured by tail cuff method in rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61049;61040 8609235;9685318 62086 Acsm3 Bpfh1, Bp26, Bp28, Bp29 36711 1 153220905 202915231 2 - by one flank and peak markers 1 153323029 203103297 2 - by one flank and peak markers 10041;61104 SS/Jr;LEW/NCrl F2 SS/Jr x LEW/NCrLBR
61349 rat Bp31 Blood pressure QTL 31 13 5.75 33733 D13Mit2 Blood pressure increased systemic arterial blood pressure Hypertension 61043 8952608 Bp5, Bp11, Bp24, Bp25 36712 13 39572400 84572400 3 - by peak only 13 39586480 84586480 3 - by peak only 61000;61103 SHR;WKY F2 SHR x WKY
61351 rat Bp33 Blood pressure QTL 33 4 0.018 61286 Il16_mapped Blood pressure increased systemic arterial blood pressure Hypertension 61044 7560090 37902 61098;61099 BXH;HXB F2 SHR x BN
61352 rat Bp34 Blood pressure QTL 34 9 5.0 61287 D9Uia6 61288 D9Uia9 2912 Inha Blood pressure salt-loaded systolic systolic blood pressure measured by tail cuff method in rats fed a diet containing 8% NaCl for 8 weeks increased systemic arterial blood pressure Hypertension 61053;619653 9722941;11161799 39687 9 39390033 77170797 1 - by flanking markers 9 39391447 77354082 1 - by flanking markers 10040;10041 SR/Jr;SS/Jr F2 SS/Jr x SR/Jr
61354 rat Pia10 Pristane induced arthritis QTL 10 10 0.01 61274 D10Arb20 61275 D10Arb22 10466 D10Mit1 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2836;3395;3772;3773;3774;3877;61276;1594396 Hsd17b1;Prkca;Stat3;Stat5a;Stat5b;Tnfaip1;Crhr1;Trim25 Oia3, Eau3, Carrageenan, Cia5, Atps2, Aia5 45711 10 24006429 110718848 2 - by one flank and peak markers 10 24007478 110733352 2 - by one flank and peak markers 61095;631282 DA.F344(Cia5);DA.F344-(D10Rat37-D10Arb22) Congenic DA/F344 Congenic
61355 rat Bp36 Blood pressure QTL 36 2 2.9 2071 Agtr1b 33943 D2Mit1 61289 D2Mco19 Blood pressure increased systemic arterial blood pressure Hypertension 61040 9685318 Bp10 39689 2 3429900 105503269 1 - by flanking markers 2 3449439 105448230 1 - by flanking markers 10041;60999 SS/Jr;LEW F2 SS/Jr x LEW
61357 rat Bp38 Blood pressure QTL 38 7 1.6 34395 D7Mgh1 62504 D7Uia3 33648 D7Mit5 Blood pressure null increased systemic arterial blood pressure Hypertension 61040;4891049 9685318;21192272 3809;628723;735050 Tac2;Nxph4;Rdh2 39691 7 62589963 107589963 3 - by peak only 7 62610694 107610694 3 - by peak only 10041;60999;4891048;4891051 SS/Jr;LEW;SS.LEW-(D7Rat73-D7Rat128)/Ayd;LEW.SS-(D7Rat73-D7Rat128)/Ayd F2 SS/Jr x LEW
61358 rat Bp39 Blood pressure QTL 39 8 2.0 44436 D8Wox2 Blood pressure increased systemic arterial blood pressure Hypertension 61040 9685318 B22, Bp35 39692 8 38902937 83902937 3 - by peak only 8 38921991 83921991 3 - by peak only 10040;10041 SR/Jr;SS/Jr F2 SS/Jr x LEW
61360 rat Eaey Experimental allergic encephalomyelitis QTL y 18 3.0 34156 D18Mgh1 10648 D18Wox13 Brain/spinal cord inflammation duration of disease experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; duration of disease is defined as number of days for which an animal is scored as 2-8 paresis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 61031 10640775 45694 18 49034213 87265094 4 - by one flank marker only 18 49071836 87338544 4 - by one flank marker only 60997;61013 DA;E3 F2 E3 x DA
61361 rat Oia1 Oil induced arthritis QTL 1 20 Joint/bone inflammation oil induced joint swelling Arthritis, Rheumatoid 61086 8441169 39736 60997 DA F2
61363 rat Oia3 Oil induced arthritis QTL 3 10 0.001 11308 D10Wox20 34128 D10Mgh1 34128 D10Mgh1 Joint/bone inflammation oil induced joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61087;61068;62404 18606636;16804090;18540828;9600974;9692888;11230175 Oia4;Oia5;Oia6;Oia2;Cia5 39731 10 91455572 110718848 4 - by one flank marker only 10 91469942 110733352 4 - by one flank marker only 631595 LEW.1AV1.DA-(D10Rat92-D10Rat135)/Ubc F2
61364 rat Iddm2 Insulin dependent diabetes mellitus QTL 2 4 11014 D4Mit7 10782 D4Mit8 11014 D4Mit7 Glucose level insulin-dependent increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 61075;61032 1303251;9530633 3024 Lyp_mapped Lyp 34084 10002;10003;60999;70509 BBDP/Rhw;BBDR/Rhw;LEW;F344/N F2 BB/DP x BB/DR, BB/DP x F344, BB/DP x LEW
61365 rat Iddm1 Insulin dependent diabetes mellitus QTL 1 20 3.54 0.001 Glucose level insulin-dependent increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 61076;61075 7026724;1303251 34085 10002;10003;60999;70509 BBDP/Rhw;BBDR/Rhw;LEW;F344/N F2 BB/DP x BB/DR, BB/DP x F344, BB/DP x LEW
61367 rat Iddm4 Insulin dependent diabetes mellitus QTL 4 18 2.33 0.0074 2715 Gnal Glucose level insulin-dependent increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 61077;61075;625443 9571179;1303251;8586150 41097 18 41165704 86165704 3 - by peak only 6 110587494 147642806 3 - by peak only 60997;61107 DA;BB/OK F2;backcross BB/OKxDA
61368 rat Mcs1 Mammary carcinoma susceptibility QTL 1 2 4.4 33822 D2Mit29 61291 D2Uwm15 35901 D2Rat3 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;61080;61081 18057545;8168109;9584103 34166 2 5601528 22318848 1 - by flanking markers 2 5627976 22239217 1 - by flanking markers 60998;61007 COP;WF (WF x COP) F1 x WF backcross WF x COP
61370 rat Mcs3 Mammary carcinoma susceptibility QTL 3 1 2.15 33686 D1Mit11 34011 D1Mit2 60787 D1Wox6 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;61081 18057545;9584103 39287 1 102532146 134980682 1 - by flanking markers 1 102610256 135059025 1 - by flanking markers 60998;61007 COP;WF (WF x COP) F1 x WF backcross WF x COP
61371 rat Edpm1 Estrogen-dependent pituitary mass QTL 1 2 4.0 0.66 9.6 34278 D2Mgh14 33824 D2Mit4 61293 Mit-R718 Gland mass pituitary pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 additive 41062 2 42866226 87866226 4 - by one flank marker only 4 187218368 187371129 4 - by one flank marker only 10008;61109 BN/SsNHsd;F344/NHsd intercross F344/NHsd x BN/SsNHsd
61373 rat Mcs4 Mammary carcinoma susceptibility QTL 4 8 1.1 10437 D8Mgh13 34415 D8Mgh6 10437 D8Mgh13 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;61081 18057545;9584103 2458;2459 Cyp1a1;Cyp1a2 39288 8 61443447 64762616 1 - by flanking markers 8 61462501 64781670 1 - by flanking markers 60998;61007 COP;WF (WF x COP) F1 x WF backcross WF x COP
61374 rat Edpm2 Estrogen-dependent pituitary mass QTL 2 2 4.42 0.86 9.2 33620 D2Mit6 34461 D2Mgh12 34114 D2Mgh15 Gland mass pituitary pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 41063 2 81820429 210636169 2 - by one flank and peak markers 2 77561812 210598923 1 - by flanking markers 10008;61109 BN/SsNHsd;F344/NHsd intercross F344/NHsd x BN/SsNHsd
61376 rat Bp42 Blood pressure QTL 42 1 23.4 2870 Igf2 10674 D1Mgh12 Blood pressure increased systemic arterial blood pressure Hypertension 61055 9199194 39720 1 202906624 247322277 1 - by flanking markers 1 203094689 247436752 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol F2 BB/OK x SHR/Mol
61377 rat Edpm3 Estrogen-dependent pituitary mass QTL 3 3 7.05 0.038 16.6 10293 D3Mit7 34146 D3Mgh6 Gland mass pituitary pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074;1581610 9337394;16416090 additive 45204 3 50522717 88648420 1 - by flanking markers 3 50419089 88544848 1 - by flanking markers 10008;61109 BN/SsNHsd;F344/NHsd intercross F344/NHsd x BN/SsNHsd
61378 rat Bp43 Blood pressure QTL 43 1 22.6 3750 Spn 3643 Sct Blood pressure increased systemic arterial blood pressure Hypertension 61055 9199194 39721 1 186388120 201472944 1 - by flanking markers 1 186538248 201623978 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol F2 BB/OK x SHR/Mol
61379 rat Bp44 Blood pressure QTL 44 1 19.2 62086 Acsm3 33959 D1Mit3 Blood pressure increased systemic arterial blood pressure Hypertension 61055 9199194 39722 1 146971983 178054386 1 - by flanking markers 1 147050389 178212017 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol F2 BB/OK x SHR/Mol
61380 rat Edpm5 Estrogen-dependent pituitary mass QTL 5 5 4.5 0.92 9.4 34216 D5Mgh6 34041 D5Mit5 33985 D5Mit11 Gland mass pituitary pituitary gland hyperplasia Pituitary Neoplasms;Neoplasms, Hormone-Dependent 61074;1300042 9337394;15166088 additive 45205 5 71814715 109163425 1 - by flanking markers 5 71819829 109168651 1 - by flanking markers 10008;61109;1331830 BN/SsNHsd;F344/NHsd;F344.BN-(D5Rat1-D5Mit5)/Dlw intercross F344/NHsd x BN/SsNHsd
61381 rat Bp45 Blood pressure QTL 45 10 23.2 3385 Ppy 61296 Abp1 Blood pressure increased systemic arterial blood pressure Hypertension 61055 9199194 39723 61107;61110 BB/OK;SHR/Mol F2 BB/OK x SHR/Mol
61382 rat Bp46 Blood pressure QTL 46 18 18.8 3916 Ttr 2741 Nr3c1 Blood pressure increased systemic arterial blood pressure Hypertension 61055 9199194 Bp47;Bp48;Bp2, Bp32 39724 18 12406571 32459145 1 - by flanking markers 18 12433216 32494411 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol intercross;F2 BB/OK x SHR/Mol
61383 rat Bp47 Blood pressure QTL 47 18 17.3 2741 Nr3c1 2690 Gja1 Blood pressure increased systemic arterial blood pressure Hypertension 61055 9199194 Bp46;Bp48 39725 61107;61110 BB/OK;SHR/Mol F2 BB/OK x SHR/Mol
61384 rat Bp48 Blood pressure QTL 48 18 19.4 2715 Gnal 33814 D18Mit9 Blood pressure increased systemic arterial blood pressure Hypertension 61055 9199194 Bp46;Bp47;Bp34 39726 18 63595606 80370517 1 - by flanking markers 18 63714065 80444102 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol intercross;F2 BB/OK x SHR/Mol
61385 rat Edpm9 Estrogen-dependent pituitary mass QTL 9 9 3.43 0.36 6.5 61298 D9Mgh12 Gland mass pituitary pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 additive 45206 10008;61109 BN/SsNHsd;F344/NHsd intercross F344/NHsd x BN/SsNHsd
61386 rat Bp49 Blood pressure QTL 49 5 16.6 33836 D5Mit9 43930 D5Wox4 3193 Nppa Blood pressure increased cerebral infarction size;increased systemic arterial blood pressure Hypertension;Brain Infarction 1553895;61056 15454664;9241273 3193 Nppa 39770 5 62555131 103059258 1 - by flanking markers 5 62555311 103064484 1 - by flanking markers 61010;61103 SHRSP;WKY F2 SHRSP x WKY
61387 rat Bp1 Blood pressure QTL 1 10 5.1 33941 D10Mit11 3138 Myh3 2686 Gh1 Blood pressure increased systemic arterial blood pressure Hypertension 61036 1655275 2493 Ace Bp4,Dcp1 104 10 53800677 101848470 1 - by flanking markers 10 53814300 101862784 1 - by flanking markers 61010;61103 SHRSP;WKY intercross;F2 SHRSPxWKY
61388 rat Bp2 Blood pressure QTL 2 18 3.23 33971 D18Mit7 Blood pressure diastolic increased systemic arterial blood pressure Hypertension 61036 1655275 Bp 41, Bp46 105 18 1 35739743 3 - by peak only 18 0 35766389 3 - by peak only 61010;61103 SHRSP;WKY F2 SHRSPxWKY
61389 rat Bp3 Blood pressure QTL 3 X Blood pressure increased systemic arterial blood pressure Hypertension 61052 1656270 106 61010;61103 SHRSP;WKY F2 SHRSP x WKY
61390 rat Bp4 Blood pressure QTL 4 10 Blood pressure increased systemic arterial blood pressure Hypertension 61052 1656270 Bp1 107 61010;61103 SHRSP;WKY F2 SHRSP x WKY
61391 rat Bp5 Blood pressure QTL 5 13 5.6 3554 Ren Blood pressure diastolic increased systemic arterial blood pressure Hypertension 61057 7981757 Bp11, Bp24, Bp25, Bp31 108 13 23769074 68769074 3 - by peak only 13 23782624 68782624 3 - by peak only 10021;60990;61015 LH/Mav;LH;LN F2 LH x LN
61392 rat Bp6 Blood pressure QTL 6 2 7.0 2391 Cpb1 Blood pressure increased systemic arterial blood pressure Hypertension 61057 7981757 Bp13 109 2 82928622 127928622 3 - by peak only 2 82873584 127873584 3 - by peak only 10021;60990;61015 LH/Mav;LH;LN F2 LH x LN
61393 rat Bp7 Blood pressure QTL 7 5 4.5 1.0E-4 33836 D5Mit9 61299 D5Mco10 2533 Edn2 Blood pressure salt-loaded systolic indirect systolic blood pressure measured by tail cuff method on rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61059;61040;619653 8201007;9685318;11161799 2533 Edn2 110 5 62555131 168174140 1 - by flanking markers 5 62555311 168184328 1 - by flanking markers 10041;60999 SS/Jr;LEW F2 SS/Jr x LEW
61394 rat Bp8 Blood pressure QTL 8 17 2.2 8.5 61300 D17Mco3 61301 D17Mco10 10709 D17Mgh3 Blood pressure salt-loaded systolic indirect systolic blood pressure measured by tail cuff method on rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61059;61040 8201007;9685318 111 17 28967455 67955655 2 - by one flank and peak markers 17 28970495 70299879 1 - by flanking markers 10041;60999 SS/Jr;LEW F2 SS/Jr x LEW
61395 rat Nka1 Natural killer alloreactivity QTL 1 4 Natural killer alloreactivity impaired NK cell cytolysis Autoimmune Diseases 61084;61085 9521051;8642329 34231 60997;61006 DA;PVG
61396 rat Bp9 Blood pressure QTL 9 10 4.8 1.0E-4 2493 Ace Blood pressure salt-loaded systolic systolic blood pressure measured by tail cuff method in rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61037;61039;70857 1363813;7537756;9299556 2493 Ace 34598 10 72871396 110718848 3 - by peak only 10 72885766 110733352 3 - by peak only 10041;60992 SS/Jr;MNS F2 SS/Jr x MNS, LEW x SS/Jr, WKY x SS/Jr
61397 rat Bw17 Body weight QTL 17 7 6.3 24.0 10935 D7Wox14 10427 D7Wox19 10431 D7Wox18 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Body Weight Changes 61061 8528248 116 7 98955084 113044249 1 - by flanking markers 7 98989314 113078479 1 - by flanking markers 10017;60985 GK/KyoSwe;BN intercross;F2 GK x BN
61398 rat Bp50 Blood pressure QTL 50 2 4.4 33727 D2Mit14 33763 D2Mit15 Blood pressure systolic increased systemic arterial blood pressure Hypertension 61058 9329963 44495 2 197256223 242256223 4 - by one flank marker only 2 197218978 237337757 1 - by flanking markers 60990;61015 LH;LN F2 LH x LN
61399 rat Tcat1 Tongue tumor resistance QTL 1 1 3.3 34037 D1Mit1 33959 D1Mit3 Tongue tumor resistance abnormal Hensen cell morphology Tongue Neoplasms 61091 9563479 44502 1 101971983 146971983 4 - by one flank marker only 1 56717951 147050389 1 - by flanking markers 61007;61111 WF;DA/Slc F1 DA/Slc x WF
61400 rat Niddm1 Non-insulin dependent diabetes mellitus QTL 1 1 11.0 33945 D1Mit18 10805 D1Mgh13 33903 D1Mit7 Glucose level postprandial intraperitoneal glucose tolerance test (IPGTT) performed at 65 days of age, blood glucose levels measured after tail-vein incision at 0, 30min, 60 min, and 120 min after injection increased body weight;impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 61082 8528247 Nidd/Gk1 34228 1 224426266 252340527 1 - by flanking markers 1 224590289 252605100 1 - by flanking markers 10017;70509 GK/KyoSwe;F344/N intercross;F2 GKxF344;GK x F344
61401 rat Niddm2 Non-insulin dependent diabetes mellitus QTL 2 2 4.54 33763 D2Mit15 33727 D2Mit14 Glucose level postprandial intraperitoneal glucose tolerance test (IPGTT) performed at 65 days of age, blood glucose levels measured after tail-vein incision at 0, 30min, 60 min, and 120 min after injection increased circulating glucose level;impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 61082 8528247 Nidd/Gk2 34229 2 152256313 197256313 4 - by one flank marker only 2 197219067 237337296 1 - by flanking markers 10017;70509 GK/KyoSwe;F344/N F2;intercross GKxF344;GK x F344
61403 rat Niddm4 Non-insulin dependent diabetes mellitus QTL 4 1 11060 D1Wox23 33903 D1Mit7 43424 D1Wox10 Glucose level non-insulin-dependent increased body weight;abnormal pancreatic islet morphology Diabetes Mellitus, Non-Insulin-Dependent 61083 9169130 37839 1 212121314 240980321 1 - by flanking markers 1 212279744 241163920 1 - by flanking markers 61103;61112 WKY;13M F2 13M x WKY;13MxWKY
61404 rat Niddm5 Non-insulin dependent diabetes mellitus QTL 5 12 5.1 33961 D12Mit5 34373 D12Mgh6 Body weight body mass index body weight and body mass index, plasma insulin, and pancreatic morphology was assessed; body mass index was calculated from body weight and nasoanal body length; plasma glucose concentration was determined by glucose oxidase assay increased body weight;increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent 61083;61021 9169130;10051320 37840 12 12770194 46782294 4 - by one flank marker only 12 12800123 46649226 4 - by one flank marker only 61103;61112 WKY;13M F2 13M x WKY;13MxWKY
61406 rat Scwia1 Streptococcal cell wall induced arthritis QTL 1 4 2.3 42168 D4Arb30 10266 D4Arb4 61302 D4Arb24 Joint/bone inflammation streptococcal cell wall induced joint swelling Arthritis, Rheumatoid 2307198;61064 18540828;10331011 3197;3834 Npy;Tcrb Cia3, Aia3, Iddm/Lyp, Eau1 45717 4 73972453 154937227 1 - by flanking markers 4 74248583 155182068 1 - by flanking markers 60999;70509 LEW;F344/N F2 LEWxF344
61407 rat Scl12 Serum cholesterol level QTL 12 19 0.001 2571 Ces1c 2535 Ednra 33802 D19Mit2 Lipid level HDL cholesterol increased circulating HDL cholesterol level Hyperlipidemia 61079 8698878 37898 19 14981499 32108153 1 - by flanking markers 19 14986402 32110066 1 - by flanking markers 61100;61113 SHR/Ola;BN-Lx F2 SHR/OlaxBN-lx;SHR/Ola x BN-lx
61409 rat Scl13 Serum cholesterol level QTL 13 20 3.5E-4 61303 D20Utr1 Lipid level HDL cholesterol increased circulating HDL cholesterol level Hyperlipidemia 61079 8698878 37900 61100;61113 SHR/Ola;BN-Lx F2 SHR/Ola x BN-lx
61410 rat Bw19 Body weight QTL 19 7 6.2 0.001 10764 D7Mit23 Body weight increased body weight Body Weight Changes 61082 8528247 2868 Igf1 Bw/gk1 34543 7 2051218 47051218 3 - by peak only 10017;70509 GK/KyoSwe;F344/N F2 GK x F344
61412 rat Pia2 Pristane induced arthritis QTL 2 4 3.9 34200 D4Mgh1 35260 D4Rat22 34716 D4Mgh14 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61089 18540828;18606636;16804090;9843218 dominant Aia2 44526 4 17617956 60974511 1 - by flanking markers 4 17617956 61250641 1 - by flanking markers 60997;61013 DA;E3 F2;intercross E3 x DA
61413 rat Eae10 Experimental allergic encephalomyelitis QTL 10 14 3.5 33551 D14Mit6 10135 D14Wox11 Brain/spinal cord inflammation relapsing disease experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; relapsing disease is defined as more than one relapse, or period of increase in clinical score of one or more for three days paresis Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 61031 10640775 Pia 6 44541 14 19142085 19800225 1 - by flanking markers 14 19142085 19800225 1 - by flanking markers 60997;61013 DA;E3 F2 E3 x DA
61415 rat Eae11 Experimental allergic encephalomyelitis QTL 11 4 2.9 11378 D4Wox30 34716 D4Mgh14 Brain/spinal cord inflammation onset of disease experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; onset of disease is defined as the first day a clinical score of 1 or higher was obtained paresis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 61031 10640775 Pia 2 44542 4 1 36592773 4 - by one flank marker only 4 0 36711313 4 - by one flank marker only 60997;61013 DA;E3 F2 E3 x DA
61416 rat Pia4 Pristane induced arthritis QTL 4 12 8.4 44950 D12Wox5 35433 D12Rat17 11449 D12Wox14 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61089 18606636;16804090;18540828;9843218 additive 44528 60997;61013 DA;E3 F2;intercross E3 x DA;E3xDA
61418 rat Pia5 Pristane induced arthritis QTL 5 4 4.5 35260 D4Rat22 33933 D4Mit16 10561 D4Wox20 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling;joint inflammation Arthritis, Rheumatoid 2307198;2300074;1582387;61089 18540828;18606636;16804090;9843218 additive Cia3, Aia3;Aia3 44529 4 60974346 130228614 1 - by flanking markers 4 61250477 130473455 1 - by flanking markers 60997;61013 DA;E3 F2;intercross E3 x DA
61419 rat Cia11 Collagen induced arthritis QTL 11 3 5.6 12.1 33862 D3Mit9 34228 D3Mgh5 11261 D3Wox9 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61066 18540828;18606636;16804090;10857786 2237;2726;3439;3632 C5;Gpd2;Ptgs1;Scn2a1 45678 3 26674018 97524000 1 - by flanking markers 3 26570390 97420428 1 - by flanking markers 61114;61115 DA/Bkl;BN/SsN F2;intercross DA/Bkl x BN/SsN
61420 rat Pia6 Pristane induced arthritis QTL 6 14 4.9 10622 D14Mgh3 11030 D14Mit4 35342 D14Rat8 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61089 18606636;16804090;18540828;9843218 recessive 44530 14 20165393 45020354 1 - by flanking markers 14 20165393 44925828 1 - by flanking markers 60997;61013 DA;E3 F2;intercross E3 x DA
61422 rat Cia13 Collagen induced arthritis QTL 13 4 4.5 34001 D4Mit17 34338 D4Mgh11 33768 D4Mit14 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for the swelling size of multiple joints; joints were measured twice weekly following collagen injection joint swelling;joint inflammation Arthritis, Rheumatoid 2307198;2300074;1582387;61067;61066;629560 18540828;18606636;16804090;11001927;10857786;12571866 Pia7, Oia2;Oia2 45680 4 134858561 171204531 1 - by flanking markers 4 135103402 171449467 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61423 rat Cia14 Collagen induced arthritis QTL 14 19 3.0 7.3 33951 D19Mit8 61309 D19Arb7 34033 D19Mit5 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61066 18540828;18606636;16804090;10857786 45681 19 24304442 45692656 2 - by one flank and peak markers 19 24309323 45697537 2 - by one flank and peak markers 61114;61115 DA/Bkl;BN/SsN F2 DA/Bkl x BN/SsN
61425 rat Cia15 Collagen induced arthritis QTL 15 9 4.6 35695 D9Rat44 42251 D9Arb7 34264 D9Mgh5 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61067 18606636;16804090;18540828;11001927 45682 9 2948882 39821284 1 - by flanking markers 9 2948882 39822698 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61426 rat Scl2 Serum cholesterol level QTL 2 5 7.3 0.001 28.0 34322 D5Mgh10 34443 D5Mgh8 34041 D5Mit5 Lipid level cholesterol decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 45713 5 62098646 149757440 1 - by flanking markers 5 62098825 149767479 1 - by flanking markers 61103;61116 WKY;SHRSP/A3 F2;intercross SHRSP/A3 x WKY
61334 rat Gluco17 Glucose level QTL 17 12 6.3 34025 D12Mit8 34439 D12Mgh1 Glucose level uptake insulin mediated and basal glucose uptake levels were measured in adipocytes isolated from male rats decreased circulating insulin level Insulin Resistance 61078 9171835 dominant 37904 12 1 12240883 4 - by one flank marker only 61096;61097 SHR/NCruk;WKY/NCruk F2
61333 rat Gluco16 Glucose level QTL 16 4 4.3 42144 D4Arb13 Glucose level uptake insulin mediated and basal glucose uptake levels were measured in adipocytes isolated from male rats decreased circulating insulin level Insulin Resistance 61078 9171835 37903 4 1 25671721 3 - by peak only 4 0 25671721 3 - by peak only 61096;61097 SHR/NCruk;WKY/NCruk F2
61335 rat Bp20 Blood pressure QTL 20 3 3.0 34316 D3Mgh2 33810 D3Mit2 Blood pressure salt-loaded systolic systolic, diastolic, mean blood pressures and heart rate measured directly through a femoral catheter inserted in rats following treatment for 13 days with a diet including water with 1% NaCl increased systemic arterial blood pressure Hypertension 61045 9132270 36645 3 158037866 171063335 4 - by one flank marker only 3 143120359 157943902 1 - by flanking markers 60985;61000 BN;SHR F2 SHR x BN
61336 rat Bp21 Blood pressure QTL 21 4 4.6 3197 Npy 33757 D4Mit2 Blood pressure salt-loaded systolic systolic, diastolic, mean blood pressures and heart rate measured directly through a femoral catheter inserted in rats following treatment for 13 days with a diet including water with 1% NaCl increased systemic arterial blood pressure Hypertension 61045;631223 9132270;11474180 3239 Oxtr 36646 4 55370202 78038013 1 - by flanking markers 4 55621035 78314142 1 - by flanking markers 60985;61000 BN;SHR F2 SHR x BN
61369 rat Mcs2 Mammary carcinoma susceptibility QTL 2 7 3.38 34166 D7Mgh15 61292 D7Uwm9 34051 D7Mit28 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;61081 18057545;9584103 39286 7 21161002 38377911 1 - by flanking markers 7 21181273 38398182 1 - by flanking markers 60998;61007 COP;WF (WF x COP) F1 x WF backcross WF x COP
61344 rat Bp29 Blood pressure QTL 29 1 7.5 34011 D1Mit2 60784 D1Wox29 Blood pressure systolic systolic and diastolic blood pressures measured directly in 25 week old rats through a lower aortic cannula inserted via the femoral artery increased systemic arterial blood pressure Hypertension 61051;628394 9774356;12215469 Bpfh1, Bp26 Bp28, Bp30 36713 1 124614852 134980526 1 - by flanking markers 1 124693195 135058870 1 - by flanking markers 61000;61103 SHR;WKY F2 SHR x WKY
61347 rat Bp197 Blood pressure QTL 197 1 4.2 3118 Mt1-ps1 Blood pressure increased systemic arterial blood pressure Hypertension 1643000;61060 17413446;8528250 Bp26, Bp28, Bp29, Bp30 112 1 163190108 208190108 3 - by peak only 1 163340036 208340036 3 - by peak only 10000;60993 ACI/N;FHH (FHH x ACI) x FHH Backcross FHH x ACI
61350 rat Bp32 Blood pressure QTL 32 19 0.012 33618 D19Mit7 Blood pressure increased systemic arterial blood pressure Hypertension 61044 7560090 37901 19 22590859 59218465 3 - by peak only 19 22595701 59223525 3 - by peak only 61098;61099 BXH;HXB F2 SHR x BN
61353 rat Bp35 Blood pressure QTL 35 8 33628 D8Mit6 3544 Rbp2 Blood pressure increased systemic arterial blood pressure Hypertension 61054 9045857 Bp22, Bp39 39688 8 9581132 103685771 1 - by flanking markers 8 9581132 103705027 1 - by flanking markers 61106 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv F2
61356 rat Bp37 Blood pressure QTL 37 3 3.0 34146 D3Mgh6 Blood pressure salt-loaded systolic systolic blood pressure measured by tail cuff method in rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61040;631223 9685318;11474180 3238 Oxt 39690 3 28022667 73022667 3 - by peak only 3 27919040 72919040 3 - by peak only 10041;60999 SS/Jr;LEW F2 SS/Jr x LEW
61359 rat Eaex Experimental allergic encephalomyelitis QTL x 5 3.0 33678 D5Mit10 43924 D5Wox21 Brain/spinal cord inflammation onset of disease experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8; onset of disease is defined as the first day a clinical score of 1 or higher was obtained paresis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 61031 10640775 45693 5 57974567 102974567 4 - by one flank marker only 5 57974747 102974747 4 - by one flank marker only 60997;61013 DA;E3 F2 E3 x DA
61362 rat Oia2 Oil induced arthritis QTL 2 4 0.001 34174 D4Mgh7 33778 D4Mit21 34473 D4Mgh10 Joint/bone inflammation oil induced arthritis severity after adjuvant injection was measured via a cumulative scoring system for multiple joints; animals were evaluated twice a week for six weeks joint swelling;joint inflammation Arthritis, Rheumatoid 2300074;1582387;61087;61068;2324629;629560 18606636;16804090;9600974;9692888;20200546;12571866 Cia13;Pia7;Oia3, Pia7, Cia3, Cia13;Cia3 39732 4 136668162 181668162 3 - by peak only 4 158870655 159955541 2 - by one flank and peak markers 60997;60999 DA;LEW F2
61366 rat Iddm3 Insulin dependent diabetes mellitus QTL 3 2 4.7 33727 D2Mit14 33763 D2Mit15 Glucose level IPGTT performed at 65 days of age increased circulating glucose level;obese Diabetes Mellitus, Insulin-Dependent 61481;61075 10441739;1303251 34086 2 197256223 242256223 4 - by one flank marker only 2 197218978 237337757 1 - by flanking markers 10003;70509 BBDR/Rhw;F344/N F2 (F344 +/+,lv/lv x BB/DR lyp/lyp,u/u) x BB/DR lyp/lyp,u/u
61372 rat Bp40 Blood pressure QTL 40 16 2.2 11448 D16Wox11 33848 D16Mit2 11448 D16Wox11 Blood pressure increased systemic arterial blood pressure Hypertension 61040 9685318 39693 16 4304517 18121285 1 - by flanking markers 16 4304515 18121283 1 - by flanking markers 10041;60999 SS/Jr;LEW F2 SS/Jr x LEW
61375 rat Bp41 Blood pressure QTL 41 18 2.4 61294 D18Mco3 11461 D18Mit1 33766 D18Mit4 Blood pressure increased systemic arterial blood pressure Hypertension 61040 9685318 Bp2 39694 18 1 80277631 2 - by one flank and peak markers 18 12433620 42451758 2 - by one flank and peak markers 10040;10041 SR/Jr;SS/Jr F2 SS/Jr x SR/Jr
61402 rat Niddm3 Non-insulin dependent diabetes mellitus QTL 3 10 4.58 34274 D10Mgh5 34445 D10Mgh6 Glucose level postprandial intraperitoneal glucose tolerance test (IPGTT) performed at 65 days of age, blood glucose levels measured after tail-vein incision at 0, 30min, 60 min, and 120 min after injection increased circulating glucose level;impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 61082 8528247 34230 10 86316831 110718848 4 - by one flank marker only 10 86331202 110733352 4 - by one flank marker only 10017;70509 GK/KyoSwe;F344/N F2;intercross GKxF344;GK x F344
61405 rat Niddm6 Non-insulin dependent diabetes mellitus QTL 6 16 3.66 0.001 33848 D16Mit2 43072 D16Rat116 33848 D16Mit2 Glucose level increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent 61083;61021 9169130;10051320 37841 16 4304396 52304351 1 - by flanking markers 16 4304394 52304426 1 - by flanking markers 61103;61112 WKY;13M F2 13M x WKY;13MxWKY
61408 rat Scl23 Serum cholesterol level QTL 23 4 5.0E-4 2901 Il6 Lipid level HDL phospholipid increased circulating HDL cholesterol level Hyperlipidemia 61079 8698878 37899 4 1 22959087 3 - by peak only 4 0 22959087 3 - by peak only 61100;61113 SHR/Ola;BN-Lx F2 SHR/Ola x BN-lx
61411 rat Pia1 Pristane induced arthritis QTL 1 20 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2300074;1582387;61088;61089 18606636;16804090;8909256;9843218 Pia21 44531 60997;61013 DA;E3 intercross
61414 rat Pia3 Pristane induced arthritis QTL 3 6 4.5 33662 D6Mit1 36057 D6Rat4 44173 D6Wox5 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61089;728382 18540828;18606636;16804090;9843218;14611807 dominant 44527 6 98840516 144200901 1 - by flanking markers 6 98843972 144207088 1 - by flanking markers 60997;61013 DA;E3 intercross;F2 E3 x DA
61417 rat Cia10 Collagen induced arthritis QTL 10 2 3.4 34461 D2Mgh12 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for the swelling size of multiple joints; joints were measured twice weekly following collagen injection joint inflammation;joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61063;61064;61065 18540828;18606636;16804090;9870869;10331011;10631556 2297;2310;2902;3205;3952;628704;1598328 Cd2;Cd53;Il6ra;Nras;Vcam1;Il12b;Ngf additive might represent an extension effect from Cia7 45677 2 188136088 233136088 3 - by peak only 2 188098843 233098843 3 - by peak only 10000;61114;2302387 ACI/N;DA/Bkl;DA.ACI-(D2Mit12-D2Mgh29)/Nsi F2 DA/Bkl x ACI
61421 rat Cia12 Collagen induced arthritis QTL 12 12 4.6 10.2 44950 D12Wox5 41962 D12Arb6 10888 D12Wox10 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61066 18606636;16804090;18540828;10857786 2621;3282;61306;61307;61308 Flt1;Pdgfa;Hspb1;Ncf1;Flt3 Pia4 45679 12 1 44521457 3 - by peak only 12 7259304 36758138 2 - by one flank and peak markers 61114;61115 DA/Bkl;BN/SsN F2 DA/Bkl x BN/SsN
61424 rat Scl1 Serum cholesterol level QTL 1 15 7.7 0.001 16.0 34453 D15Mgh7 2536 Ednrb 34353 D15Mgh2 Lipid level cholesterol decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 45712 15 18710622 87898700 1 - by flanking markers 15 18710623 87914471 1 - by flanking markers 61103;61116 WKY;SHRSP/A3 F2;intercross SHRSP/A3 x WKY
61427 rat Cia16 Collagen induced arthritis QTL 16 10 3.2 37464 D10Rat95 35256 D10Rat11 35449 D10Rat49 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61067 18606636;16804090;18540828;11001927 45683 10 6380753 100633982 1 - by flanking markers 10 6380796 100648218 1 - by flanking markers 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61430 rat Cia18 Collagen induced arthritis QTL 18 X 3.1 45715 DXWox2 43947 DXWox3 45715 DXWox2 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61067 18540828;18606636;16804090;11001927 45685 X 4384157 49384157 3 - by peak only X 4437627 49437627 3 - by peak only 10003;60985 BBDR/Rhw;BN F2 BB/DRxBN
61433 rat Cia2 Collagen induced arthritis QTL 2 1 5.0 42083 D1Arb37 10335 D1Arb36 39312 D1Rat212 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint swelling;joint inflammation Arthritis, Rheumatoid 2300074;1582387;2307198;61062;61068 18606636;16804090;18540828;8782824;9692888 3852;61310 Tgfbr1;Pkrcg 32928 1 33134522 78134522 4 - by one flank marker only 1 33231434 78231434 4 - by one flank marker only 61109;61114 F344/NHsd;DA/Bkl F2 DA/Bkl x F344/NHsd
61460 rat Niddm9 Non-insulin dependent diabetes mellitus QTL 9 4 3.4 1.0E-4 10.0 60802 D4Wox3 Insulin level intravenous glucose tolerance and insulin secretion tests (IVGTT) were performed in 16 week old rats increased circulating insulin level Diabetes Mellitus, Non-Insulin-Dependent 61061 8528248 34224 10017;60985 GK/KyoSwe;BN F2;intercross GK x BN;GKxBN
61463 rat Bp12 Blood pressure QTL 12 10 6.3 1.0E-4 3185 Nos2 Blood pressure salt-loaded systolic systolic blood pressure measured by tail cuff method in rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61037;61039;61040 1363813;7537756;9685318 3185 Nos2 34601 10 42554668 87554668 3 - by peak only 10 42568456 87568456 3 - by peak only 10040;10041;60999 SR/Jr;SS/Jr;LEW F2 SS/Jr x LEW, SR/Jr x LEW
61466 rat Niddm12 Non-insulin dependent diabetes mellitus QTL 12 17 3.2 0.001 11.0 10350 D17Wox12 45485 D17Wox9 Glucose level fasting increased circulating glucose level;increased body weight Diabetes Mellitus, Non-Insulin-Dependent 61061 8528248 34227 17 60586065 71214851 2 - by one flank and peak markers 17 60596898 71225684 2 - by one flank and peak markers 10017;60985 GK/KyoSwe;BN F2;intercorss GK x BN;GKxBN
61469 rat Bp16 Blood pressure QTL 16 2 5.64 60797 D2Wox7 Blood pressure increased systemic arterial blood pressure Hypertension 61043 8952608 2167 Atp1a1 36654 2 177484675 222484675 3 - by peak only 2 177447430 222447430 3 - by peak only 61000;61103 SHR;WKY F2 SHRxWKY
61472 rat Aia1 Adjuvant induced arthritis QTL 1 20 18.0 0.001 11206 D20Arb2 61316 D20Arb8 11428 D20Wox3 Joint/bone inflammation adjuvant induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61035 18540828;18606636;16804090;9780220 Cia1, Ciaa1, Oia1, Pia1 45637 20 2790511 47790511 4 - by one flank marker only 20 2790738 4531120 2 - by one flank and peak markers 60997;70509 DA;F344/N F2 DAxF344
61475 rat Aia2 Adjuvant induced arthritis QTL 2 4 5.8 42158 D4Arb26 42168 D4Arb30 34282 D4Mgh15 Joint/bone inflammation adjuvant induced joint inflammation;joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;61035;629560 18606636;16804090;18540828;9780220;12571866 Pia2;Iddm4, Eau1, Pia2 45638 4 36592628 73972591 1 - by flanking markers 4 36711168 74248721 1 - by flanking markers 60997;70509 DA;F344/N F2 DAxF344
70204 rat Niddm20 Non-insulin dependent diabetes mellitus QTL 20 14 5.1 8.0E-6 34981 D14Rat23 45195 D14Wox7 37030 D14Rat3 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance;impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 1643009;69691;69696;625760 17710484;9824537;10594234;12420133 45190 14 1764386 18915962 2 - by one flank and peak markers 14 1764386 18915988 2 - by one flank and peak markers 69643;734526;1302661 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D14Rat23-D14Rat12)/Tj F2 OLETF/OtkxF344/Crj
70205 rat Gcr3 Gastric cancer resistance QTL 3 16 2.2 11446 D16Mgh4 42018 D16Arb3 37054 D16Rat17 Gastric tumor resistance tumor invasions depth decreased incidence of induced tumors Stomach Neoplasms 69698 10706129 45707 16 18121291 70196693 1 - by flanking markers 16 18121289 70196958 1 - by flanking markers 10000;60986 ACI/N;BUF/N F2 (ACIxBUF)xACI
70206 rat Alc20 Alcohol consumption QTL 20 8 2.0 33559 D8Mit5 36117 D8Rat46 Consumption level alcohol preference alcohol preference Alcoholism 69704 9880658 2520;2846 Drd2;Htr1b 45085 8 32203394 43314410 1 - by flanking markers 8 32212161 43323174 1 - by flanking markers 634380;634381 P;NP intercross PxNP
70207 rat Niddm31 Non-insulin dependent diabetes mellitus QTL 31 7 3.9 35237 D7Rat35 34880 D7Rat31 Glucose level fasting plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696 10594234 45201 7 20307479 28488710 1 - by flanking markers 7 20322993 28508913 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got F2 OLETF/OtkxF344/Crj
70208 rat Niddm22 Non-insulin dependent diabetes mellitus QTL 22 11 3.61 10375 D11Mgh1 34112 D11Mgh4 Glucose level fasting plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance;impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69691;69696;625760 9824537;10594234;12420133 45192 11 61504483 84560092 1 - by flanking markers 11 61562072 84600689 1 - by flanking markers 69643;734526;1302663 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D11Rat4-D11Rat1)/Tj F2 OLETF/OtkxF344/Crj
70209 rat Niddm23 Non-insulin dependent diabetes mellitus QTL 23 1 2.82 11439 D1Mit30 43377 D1Wox9 Glucose level fasting plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696;625760 10594234;12420133 45193 1 94473940 203416143 1 - by flanking markers 1 94552051 203569596 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got F2 OLETF/OtkxF344/Crj
70210 rat Cm15 Cardiac mass QTL 15 17 6.5 22.0 45485 D17Wox9 35883 D17Rat44 36315 D17Rat41 Cardiac mass right ventricle pulmonary artery pressure and cardiac chamber volume were measured after placement in a normobaric hypoxic chamber (10% oxygen) for 3 weeks; right ventricle was dissected free and weighed heart right ventricle hypertrophy Hypertension, Pulmonary 69699 11157698 2343;620314 Chrm3;Ryr2 dominant 45709 17 65900398 81612488 1 - by flanking markers 17 65911232 81623321 1 - by flanking markers 61103;70509 WKY;F344/N F2 F344xWKY
70211 rat Niddm24 Non-insulin dependent diabetes mellitus QTL 24 1 3.79 10674 D1Mgh12 35457 D1Rat90 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696;625760 10594234;12420133 45194 1 247322146 267111153 1 - by flanking markers 1 247436621 267322172 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got F2 OLETF/OtkxF344/Crj
70212 rat Niddm25 Non-insulin dependent diabetes mellitus QTL 25 5 3.54 34377 D5Mgh4 33680 D5Mit13 34047 D5Mit1 Glucose level fasting plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696;625760 10594234;12420133 45195 5 1 138272129 2 - by one flank and peak markers 5 0 138277355 2 - by one flank and peak markers 69643;734526;1302667 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D5Mgh5-D5Mgh23)/Tj F2 OLETF/OtkxF344/Crj
70213 rat Niddm27 Non-insulin dependent diabetes mellitus QTL 27 12 3.72 34417 D12Mgh2 33963 D12Mit4 34729 D12Mgh5 Glucose level fasting plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696;625760 10594234;12420133 45197 12 18937438 39323046 2 - by one flank and peak markers 12 18800826 39186434 2 - by one flank and peak markers 69643;734526;1302635 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D12Rat8-D12Rat16)/Tj F2 OLETF/OtkxF344/Crj
70363 rat Bp71 Blood pressure QTL 71 10 0.04 34445 D10Mgh6 38516 D10Rat106 Blood pressure increased systemic arterial blood pressure Hypertension 69734 11471055 3185 Nos2 45767 10 40489479 85489479 4 - by one flank marker only 10 40503848 85503848 4 - by one flank marker only 631220 SS.LEW-(D10Mco1-D10Mco31)/Ayd
70364 rat Bp72 Blood pressure QTL 72 10 40794 D10Rat141 35256 D10Rat11 Blood pressure increased systemic arterial blood pressure Hypertension 69734 11471055 2493 Ace 45768 10 55633982 100633982 4 - by one flank marker only 10 55648218 100648218 4 - by one flank marker only 631701;631703;728137;728140 SS.LEW-(D10Rat11-D10Mgh1);SS.LEW-(D10Rat207-D10Mgh1)/Ayd;SS.LEW-(D10Rat141-D10Mgh1)/Ayd;SS.LEW-(D10Rat11-D10Mgh1)/Ayd
70153 rat Bp59 Blood pressure QTL 59 14 3.2 40852 D14Rat90 41138 D14Rat94 2041 Add1 Blood pressure direct systolic increased systemic arterial blood pressure Hypertension 69692 11082136 2041 Add1 45650 14 73956596 89192873 1 - by flanking markers 14 73958987 89212018 1 - by flanking markers 10025;10028 MHS/Gib;MNS/Gib F2 MHSxMNS
70154 rat Insul2 Insulin level QTL 2 20 3.75 33563 D20Mit5 34280 D20Mgh4 Insulin level post-pancreatectomy decreased circulating insulin level Diabetes Mellitus, Non-Insulin-Dependent 69703 9819774 45142 20 6880471 18245770 1 - by flanking markers 20 6880698 18259570 1 - by flanking markers 61014;70509 OLETF;F344/N F2 F344xOLETF
70155 rat Gcs1 Gastric cancer susceptibility QTL1 15 3.8 36602 D15Rat29 34357 D15Mgh4 40106 D15Rat102 Gastric tumor susceptibility tumor size increased incidence of induced tumors Stomach Neoplasms 69698 10706129 45708 15 83349477 108387242 1 - by flanking markers 15 83365257 108403023 1 - by flanking markers 10000;60986 ACI/N;BUF/N (ACIxBUF)xACI
70156 rat Niddm30 Non-insulin dependent diabetes mellitus QTL 30 5 3.98 34581 D5Mgh27 34168 D5Mgh22 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696 10594234 45200 5 135910738 157584492 1 - by flanking markers 5 135915964 157594531 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got F2 OLETF/OtkxF344/Crj
70157 rat Niddm32 Non-insulin dependent diabetes mellitus QTL 32 17 4.34 2532 Edn1 34120 D17Mgh5 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696 10594234 45202 17 28303886 59104944 1 - by flanking markers 17 28306726 59107785 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got F2 OLETF/OtkxF344/Crj
70158 rat Bp60 Blood pressure QTL 60 20 3.0 38216 D20Rat22 37570 D20Rat38 38762 D20Rat40 Blood pressure indirect systolic measured by tail-cuff method at 12 to 16 wks of age increased systemic arterial blood pressure Hypertension 69692 11082136 45651 20 30941362 36641808 2 - by one flank and peak markers 20 30955163 36655607 2 - by one flank and peak markers 10025;10028 MHS/Gib;MNS/Gib F2 MHSxMNS
70159 rat Bp61 Blood pressure QTL 61 7 1.0E-4 62494 D7Uia1 33816 D7Mit11 Blood pressure systolic systolic blood pressure measured by tail-cuff method increased systemic arterial blood pressure Hypertension 69709;69710;69711;619653 7981756;9383281;11247666;11161799 2453 Cyp11b1 45652 7 108875615 123635849 1 - by flanking markers 7 108909845 123670254 1 - by flanking markers 10040;10041 SR/Jr;SS/Jr F2 SxR
70160 rat Bw18 Body weight QTL 18 1 5.7 33959 D1Mit3 3643 Sct Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks obese Body Weight Changes 69701 9530625 45097 1 146971846 201472944 1 - by flanking markers 1 147050253 201623978 1 - by flanking markers 61000;61107 SHR;BB/OK F1xSHR (BB/OKxSHR)F1xSHR
70161 rat Bp62 Blood pressure QTL 62 8 2.9 33887 D8Mit3 40168 D8Rat133 35014 D8Rat24 Blood pressure salt-loaded systolic measured on two separate days by tail cuff method on ether-anesthetized rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61516 11015598 dominant 45653 8 45291674 94514282 1 - by flanking markers 8 45300440 94533737 1 - by flanking markers 10041;61000 SS/Jr;SHR F2;intercross SxSHR;SS/JrxSHR
70162 rat Bp63 Blood pressure QTL 63 2 5.64 60797 D2Wox7 Blood pressure increased systemic arterial blood pressure Hypertension 61043 8952608 45654 2 177484675 222484675 3 - by peak only 2 177447430 222447430 3 - by peak only 61000;61103 SHR;WKY F2 SHRxWKY
70163 rat Bw20 Body weight QTL 20 1 5.1 62086 Acsm3 10674 D1Mgh12 Body weight obese Body Weight Changes 69701 9530625 45098 1 178054386 247322277 1 - by flanking markers 1 178212017 247436752 1 - by flanking markers 61000;61107 SHR;BB/OK F1xSHR SHRx(BB/OKxSHR)F1
70164 rat Bw21 Body weight QTL 21 10 3.41 11.9 44839 D10Wox7 11479 D10Mit8 3385 Ppy Body weight obese Body Weight Changes 69691;625760 9824537;12420133 45188 10 55851811 103550924 1 - by flanking markers 10 55865434 103565294 1 - by flanking markers 69643;734526;1302630 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D10Wox7-D10Wox6)/Tj F2;intercross OLETF/OtkxF344/Crj
70165 rat Bp64 Blood pressure QTL 64 X 5.2 34559 DXMgh12 35030 DXRat2 36111 DXRat8 Blood pressure salt-loaded systolic systolic, diastolic, mean blood pressures and heart rate measured directly through a femoral catheter inserted in rats following treatment for 13 days with a diet including water with 1% NaCl increased systemic arterial blood pressure Hypertension 69713 9931114 45655 X 30326177 52447691 2 - by one flank and peak markers X 30379696 52501160 2 - by one flank and peak markers 631572;631573 SBH/Ygl;SBN/Ygl F2 SBHxSBN
70166 rat Bp65 Blood pressure QTL 65 X 5.8 35030 DXRat2 36474 DXRat4 36474 DXRat4 Blood pressure salt-loaded systolic systolic, diastolic, mean blood pressures and heart rate measured directly through a femoral catheter inserted in rats following treatment for 13 days with a diet including water with 1% NaCl increased systemic arterial blood pressure Hypertension 69713 9931114 45656 X 994805 45994805 3 - by peak only X 1048124 46048124 3 - by peak only 631573;631574 SBN/Ygl;Wild/K F2 SBHxSBN
70167 rat Bw22 Body weight QTL 22 4 3.1 60732 D4Mit6 3753 Spr 11015 D4Mit24 Body weight obese Body Weight Changes 69707 9530522 45203 4 75732943 119369308 1 - by flanking markers 4 37017639 119613765 2 - by one flank and peak markers 61107;61110 BB/OK;SHR/Mol (BB/OKxSHR)F1xBB/OK
70168 rat Eae12 Experimental allergic encephalomyelitis QTL 12 10 9.0E-4 34941 D10Rat7 36283 D10Rat15 34100 D10Mgh3 Brain/spinal cord inflammation demyelination inflammation severity was assayed daily following injection with recombinant rat myelin oligodendrocyte glycoprotein (MOG) AA 1-125; animals were scored as affected if they had paresis for at least two days and/or histopathological evidence of demyelination or CNS inflammation at 40 days post-immunization paresis;demyelination;abnormal inflammatory response Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 69695 10545597 45699 10 96667338 105886241 1 - by flanking markers 10 96681708 105900648 1 - by flanking markers 10000;60997 ACI/N;DA F2 DAxACI
70169 rat Eae13 Experimental allergic encephalomyelitis QTL 13 12 0.032 36671 D12Rat19 36025 D12Rat23 36490 D12Rat18 Brain/spinal cord inflammation demyelination inflammation severity was assayed daily following injection with recombinant rat myelin oligodendrocyte glycoprotein (MOG) AA 1-125; animals were scored as affected if they had paresis for at least two days and/or histopathological evidence of demyelination or CNS inflammation at 40 days post-immunization paresis;demyelination Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 69695 10545597 45700 12 25367251 37906389 1 - by flanking markers 12 25230561 37769778 1 - by flanking markers 10000;60997 ACI/N;DA F2 DAxACI
70170 rat Eae14 Experimental allergic encephalomyelitis QTL 14 13 0.0024 36069 D13Rat23 Brain/spinal cord inflammation demyelination inflammation severity was assayed daily following injection with recombinant rat myelin oligodendrocyte glycoprotein (MOG) AA 1-125; animals were scored as affected if they had paresis for at least two days and/or histopathological evidence of demyelination or CNS inflammation at 40 days post-immunization abnormal inflammatory response;demyelination;paresis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 69695 10545597 45701 13 24701710 69701710 3 - by peak only 13 24715754 69715754 3 - by peak only 10000;60997 ACI/N;DA F2 DAxACI
70171 rat Cari1 Carrageenan-induced inflammation QTL 1 10 4.9 5.0E-4 18.0 33941 D10Mit11 11479 D10Mit8 34274 D10Mgh5 Carrageenan-induced inflammation exudate volume abnormal inflammatory response Acute-Phase Reaction 69693 10087293 dominant Cia5, Aia5 45672 10 55851811 101848470 1 - by flanking markers 10 55865434 101862784 1 - by flanking markers 60999;70509 LEW;F344/N F2 F344xLEW
70172 rat Eae15 Experimental allergic encephalomyelitis QTL 15 18 0.001 34290 D18Mgh4 33814 D18Mit9 33715 D18Mit6 Brain/spinal cord inflammation demyelination inflammation severity was assayed daily following injection with recombinant rat myelin oligodendrocyte glycoprotein (MOG) AA 1-125; animals were scored as affected if they had paresis for at least two days and/or histopathological evidence of demyelination or CNS inflammation at 40 days post-immunization increased inflammatory response;paresis;demyelination Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 69695 10545597 45702 18 80370367 85470533 2 - by one flank and peak markers 18 79658281 80444102 1 - by flanking markers 10000;60997 ACI/N;DA F2 DAxACI
70173 rat Niddm19 Non-insulin dependent diabetes mellitus QTL 19 7 4.33 5.0E-5 34132 D7Mgh18 60819 D7Wox3 44295 D7Wox6 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance;impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 1643009;69691;69696;625760 17710484;9824537;10594234;12420133 45189 7 68162496 143002779 2 - by one flank and peak markers 7 68183226 143082968 2 - by one flank and peak markers 69643;734526;1302654 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D7Mgh16-D7Mgh20)/Tj F2 OLETF/OtkxF344/Crj
70174 rat BpQTLCluster2 Blood pressure QTL cluster 2 2 2.86 34397 D2Mgh2 2391 Cpb1 Blood pressure increased systemic arterial blood pressure Hypertension 68932 10779487 45658 2 39828973 105443909 1 - by flanking markers 2 39749343 105388871 1 - by flanking markers 60990;61015 LH;LN F2 LHxLN
70175 rat BpQTLCluster3 Blood pressure QTL cluster 3 2 2.76 34461 D2Mgh12 34497 D2Mgh24 Blood pressure increased systemic arterial blood pressure Hypertension 68932 10779487 45659 2 140403692 210636008 1 - by flanking markers 2 140353655 210598763 1 - by flanking markers 61000;61103 SHR;WKY F2 SHRxWKY
70176 rat Mcsm1 Mammary carcinoma susceptibility modifier QTL 1 6 33993 D6Mit2 Mammary tumor susceptibility modification mammary adenocarcinoma Mammary Neoplasms 62417 11139513 45611 6 61787263 106787263 3 - by peak only 6 61790719 106790719 3 - by peak only 61105;737908 WKY/NHsd;WF/NHsd
70177 rat Xhs1 X-ray hypersensitivity QTL 1 4 25.1 41200 D4Rat169 34592 D4Mgh20 36043 D4Rat49 X-ray sensitivity increased cellular sensitivity to X-ray irradiation 69702 11003700 45720 4 110893772 155893772 4 - by one flank marker only 4 81100092 156138613 1 - by flanking markers 68066;634377 LEC;BN/Sea (LECxBN)xLEC
70178 rat Eaez Experimental allergic encephalomyelitis QTL z 18 2.3 33971 D18Mit7 60774 D18Wox1 Brain/spinal cord inflammation severity of disease inflammation severity was assayed daily following injection with DA rat spinal cord homogenate with animals scored for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8 abnormal inflammatory response;paresis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 61031 10640775 45695 18 13239641 58239641 4 - by one flank marker only 18 13266288 58266288 4 - by one flank marker only 60997;61013 DA;E3 F2;resistant E3 rat x susceptible DA, LOD=2.4 (severity)=2.3 (duration af disease) E3xDA
70179 rat Xhs2 X-ray hypersensitivity QTL 2 1 3.2 37198 D1Rat186 42448 D1Rat392 42449 D1Rat391 X-ray sensitivity increased cellular sensitivity to X-ray irradiation 69702 11003700 45721 1 15833442 19577925 1 - by flanking markers 1 15833505 19577987 1 - by flanking markers 68066;634377 LEC;BN/Sea (LECxBN)xLEC
70180 rat BpQTLcluster10 Blood pressure QTL cluster 10 11 3.19 33642 D11Mit1 33700 D11Mit5 Blood pressure experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate was assayed daily; assay consists of scoring animals for degree of tail and limb paralysis on a nine point scale with paralysis increasing from 0 to 8 increased systemic arterial blood pressure Hypertension 68932 10779487 45666 11 35910590 80910590 4 - by one flank marker only 11 35966825 80966825 4 - by one flank marker only 60985;61000 BN;SHR F2 SHRxBN
70181 rat BpQTLcluster11 Blood pressure QTL cluster 11 13 3.4 10462 D13Mgh13 34080 D13Mgh10 Blood pressure increased systemic arterial blood pressure Hypertension 1625678;68932 17566075;10779487 45667 13 52688796 97688796 4 - by one flank marker only 13 52877732 97877732 4 - by one flank marker only 60985;69369 BN;SS F2 SSxBN
70182 rat BpQTLcluster12 Blood pressure QTL cluster 12 15 3.53 34160 D15Mgh5 34222 D15Mgh8 2536 Ednrb Blood pressure systolic increased systemic arterial blood pressure Hypertension 68932 10779487 45668 15 80362100 102741229 1 - by flanking markers 15 80377880 102757010 1 - by flanking markers 60985;69369 BN;SS F2 SSxBN
70183 rat BpQTLcluster13 Blood pressure QTL cluster 13 16 3.325 33848 D16Mit2 34066 D16Mgh1 2708 Glud1 Blood pressure increased systemic arterial blood pressure Hypertension 68932 10779487 45669 16 4304396 46137590 1 - by flanking markers 16 4304394 46137665 1 - by flanking markers 60985;61000 BN;SHR F2 SHRxBN
70184 rat BpQTLcluster14 Blood pressure QTL cluster 14 17 3.38 33882 D17Mit2 33654 D17Mit7 2518 Drd1a Blood pressure systolic increased systemic arterial blood pressure Hypertension 68932 10779487 45670 17 14575011 38353858 1 - by flanking markers 17 14575011 38356700 1 - by flanking markers 10000;60993 ACI/N;FHH F2 FHHxACI
70185 rat BpQTLcluster15 Blood pressure QTL cluster 15 18 3.64 34290 D18Mgh4 34218 D18Mgh2 2060 Adrb2 Blood pressure systolic increased systemic arterial blood pressure Hypertension 68932 10779487 45671 18 54038662 62313296 2 - by one flank and peak markers 18 62386497 79658281 1 - by flanking markers 60985;69369 BN;SS F2 SSxBN
70186 rat Niddm26 Non-insulin dependent diabetes mellitus QTL 26 9 3.87 44567 D9Wox19 34088 D9Mgh2 36582 D9Rat21 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696;625760 10594234;12420133 45196 9 18347567 84432994 1 - by flanking markers 9 18344890 84616413 1 - by flanking markers 69643;734526;1302650 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D9Mgh8-D9Rat15)/Tj F2 OLETF/OtkxF344/Crj
70187 rat Niddm18 Non-insulin dependent diabetes mellitus QTL 18 14 16.7 35342 D14Rat8 2670 Gck Gland mass pancreas pancreatic remnant weight as a percentage of body weight was determined after sacrifice at 28 days post surgery surgery consisted of 70% pancreatectomy carried out in males at 6 weeks of age decreased pancreas regeneration Diabetes Mellitus, Non-Insulin-Dependent 2313613;69697 19575795;9745032 45091 14 32584630 86587723 1 - by flanking markers 14 32584631 86606868 1 - by flanking markers 61014;69643 OLETF;F344/DuCrlCrlj F2 OLETFxF344/Crj
70188 rat BpQTLcluster1 Blood pressure QTL cluster 1 1 4.82 33891 D10Mit5 3710 Slc4a1 Blood pressure increased systemic arterial blood pressure Hypertension 68932 10779487 45657 10 21607719 91471072 1 - by flanking markers 10 21608769 91479502 1 - by flanking markers 60985;61000 BN;SHR F2 SHRxBN
70189 rat Mcs5 Mammary carcinoma susceptibility QTL 5 5 10.51 34501 D5Mgh26 69569 D5Uwm38 35771 D5Rat22 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;1601189;62417 18057545;17404222;11139513 45607 5 58063971 139156771 1 - by flanking markers 5 58064151 139161997 1 - by flanking markers 61105;737908 WKY/NHsd;WF/NHsd
70190 rat Mcs6 Mammary carcinoma susceptibility QTL 6 7 2.29 34051 D7Mit28 35749 D7Rat45 34051 D7Mit28 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;62417 18057545;11139513 45608 7 29204226 68057251 1 - by flanking markers 7 29224498 68077981 1 - by flanking markers 61105;737908 WKY/NHsd;WF/NHsd
70191 rat BpQTLcluster4 Blood pressure QTL cluster 4 3 2.575 34347 D3Mgh16 11260 D3Mit8 3632 Scn2a1 Blood pressure systolic increased systemic arterial blood pressure Hypertension 68932 10779487 45660 3 6373335 88937877 2 - by one flank and peak markers 3 6373636 47484792 1 - by flanking markers 60985;61000 BN;SHR F2 SHRxBN
70192 rat BpQTLcluster5 Blood pressure QTL cluster 5 4 2.6 11383 D4Mit23 10144 D4Mgh16 3711 Slc4a2 Blood pressure increased systemic arterial blood pressure Hypertension 68932 10779487 45661 4 1 61646915 2 - by one flank and peak markers 4 61923045 116855526 1 - by flanking markers 60985;61000 BN;SHR F2 SHRxBN
70193 rat Mcs7 Mammary carcinoma susceptibility QTL 7 10 2.38 35627 D10Rat12 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;62417 18057545;11139513 45609 10 76698917 110718848 3 - by peak only 10 76713288 110733352 3 - by peak only 61105;737908 WKY/NHsd;WF/NHsd
70194 rat BpQTLcluster6 Blood pressure QTL cluster 6 5 Blood pressure systolic increased systemic arterial blood pressure Hypertension 68932 10779487 45662 60985;61000 BN;SHR F2 SHRxBN
70195 rat Mcs8 Mammary carcinoma susceptibility QTL 8 14 4.28 36536 D14Rat1 40104 D14Rat99 60763 D14Wox3 Mammary tumor susceptibility mammary adenocarcinoma Mammary Neoplasms 2291885;62417 18057545;11139513 45610 14 4895894 26416791 1 - by flanking markers 14 4895895 26416802 1 - by flanking markers 61105;737908 WKY/NHsd;WF/NHsd
70196 rat BpQTLcluster7 Blood pressure QTL cluster 7 6 6.82 11241 D6Mit3 33624 D6Mit12 Blood pressure intra-arterial blood pressures measured using both intra-arterial and tail-cuff methods increased systemic arterial blood pressure Hypertension 68932 10779487 45663 6 3158498 75049527 1 - by flanking markers 6 75052653 120052653 4 - by one flank marker only 60984;60985 GH;BN F2 GHxBN
70197 rat BpQTLcluster8 Blood pressure QTL cluster 8 8 3.4 10177 D8Mit7 67379 Acaa1a Blood pressure systolic increased systemic arterial blood pressure Hypertension 68932 10779487 45664 8 79313887 124313887 4 - by one flank marker only 8 79333624 124333624 4 - by one flank marker only 60985;69369 BN;SS F2 SSxBN
70198 rat BpQTLcluster9 Blood pressure QTL cluster 9 10 2.94 33891 D10Mit5 3710 Slc4a1 Blood pressure increased systemic arterial blood pressure Hypertension 68932 10779487 45665 10 21607719 91471072 1 - by flanking markers 10 21608769 91479502 1 - by flanking markers 60985;61000 BN;SHR F2 SHRxBN
70199 rat Coreg1 Compensatory renal growth QTL 1 6 11.8 12.0 36787 D6Rat37 33977 D6Mit4 33828 D6Mit9 Renal function compensatory growth increased compensatory renal growth Kidney Diseases 69708 10732705 2003;2023 Asip;Acpp co-recessive Cia1;Aia1;Oia1;Pia1 45631 6 36481546 59946874 1 - by flanking markers 6 36484499 59950000 1 - by flanking markers 61100;61117 SHR/Ola;BN-Lx/Cub SHR/OlaxBN-lx/Cub
70200 rat Alc18 Alcohol consumption QTL 18 4 9.2 11.0 34308 D4Mgh9 33656 D4Mit9 35409 D4Rat34 Consumption level alcohol preference alcohol preference Alcoholism 631849;1578304;69704;2317896 12665621;16470346;9880658;20200994 3197;3729 Npy;Snca additive 45083 4 54828166 152570244 1 - by flanking markers 4 17699990 152815206 2 - by one flank and peak markers 634380;634381 P;NP intercross PxNP
70201 rat Gcr1 Gastric cancer resistance QTL 1 4 2.7 35315 D4Rat82 35088 D4Rat59 2112 Ampp Gastric tumor resistance tumor size decreased incidence of induced tumors Stomach Neoplasms 69698 10706129 45705 4 144600129 150048167 1 - by flanking markers 4 144844971 150292996 1 - by flanking markers 10000;60986 ACI/N;BUF/N (ACIxBUF)xACI
70202 rat Alc19 Alcohol consumption QTL 19 3 2.5 33782 D3Mit10 37010 D3Rat49 Consumption level alcohol preference alcohol preference Alcoholism 69704 9880658 69364 Scn1a 45084 3 1 23762628 4 - by one flank marker only 3 13005845 23659000 1 - by flanking markers 634380;634381 P;NP intercross PxNP
70203 rat Gcr2 Gastric cancer resistance QTL 2 3 2.6 34186 D3Mgh9 37010 D3Rat49 35054 D3Rat55 Gastric tumor resistance tumor size decreased incidence of induced tumors Stomach Neoplasms 69698 10706129 45706 3 4010230 23762628 1 - by flanking markers 3 4010230 23659000 1 - by flanking markers 10000;60986 ACI/N;BUF/N (ACIxBUF)xACI
70214 rat Niddm28 Non-insulin dependent diabetes mellitus QTL 28 14 4.06 60765 D14Wox5 35837 D14Rat27 2289 Cckar Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696;625760 10594234;12420133 45198 14 42599990 81222938 1 - by flanking markers 14 42602381 81225329 1 - by flanking markers 69643;734526;1302685 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D14Rat8-D14Rat26)/Tj F2 OLETF/OtkxF344/Crj
70215 rat Niddm29 Non-insulin dependent diabetes mellitus QTL 29 16 3.54 35527 D16Rat7 36988 D16Rat15 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 69696;625760 10594234;12420133 45199 16 19510772 80047126 1 - by flanking markers 16 19510771 80047391 1 - by flanking markers 69643;734526;1302625 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D16Wox4-D16Rat13)/Tj F2 OLETF/OtkxF344/Crj
70216 rat Cm14 Cardiac mass QTL 14 3 2.1 10387 D2Mgh26 3781 Eef1a2 66594 D3Mco5 Cardiac mass body weight adjusted heart weight measured in rats fed a diet containing 8% NaCl for 35 days and adjusted for gender differences enlarged heart;increased systemic arterial blood pressure Hypertension 69705;68910 9922389;10642295 45642 10040;10041;1559044 SR/Jr;SS/Jr;SS.SR-(D3Mco19-D3Mco5)/Jr (SxR)xS
70218 rat Cm28 Cardiac mass QTL 28 9 7.3 37416 D9Rat70 61287 D9Uia6 35819 D9Rat26 Cardiac mass salt-loaded measured after 4 weeks on an 8% NaCl diet and adjusted for differences in body weight increased systemic arterial blood pressure Hypertension 61516 11015598 additive 45644 9 21667066 77171049 1 - by flanking markers 9 21668480 77354334 1 - by flanking markers 10041;61000 SS/Jr;SHR F2;intercross SxSHR;SS/JrxSHR
70219 rat Bp54 Blood pressure QTL 54 18 2.8 11461 D18Mit1 34043 D18Mit16 10689 D18Mit5 Blood pressure salt-loaded increased systemic arterial blood pressure Hypertension 69700 11015589 45645 18 64900201 80277473 1 - by flanking markers 18 12433620 64973402 1 - by flanking markers 61498;61499 BN/NHsdMcwi;SS/JrHsdMcwi F2 SSxBN
70220 rat Bp55 Blood pressure QTL 55 13 5.75 33733 D13Mit2 Blood pressure increased systemic arterial blood pressure Hypertension 61043 8952608 45646 13 39572400 84572400 3 - by peak only 13 39586480 84586480 3 - by peak only 61000;61103 SHR;WKY F2 SHRxWKY
70221 rat Bp56 Blood pressure QTL 56 X 4.9 34192 DXMgh9 33717 DXMit4 34924 DXRat15 Blood pressure salt-loaded systolic systolic, diastolic, mean blood pressures and heart rate measured directly through a femoral catheter inserted in rats following treatment for 13 days with a diet including water with 1% NaCl increased systemic arterial blood pressure Hypertension 69713 9931114 45647 X 79626109 88514168 1 - by flanking markers X 79699401 88587601 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl F2 SBHxSBN
70222 rat Eae2 Experimental allergic encephalomyelitis QTL 2 4 4.3 34200 D4Mgh1 34716 D4Mgh14 34200 D4Mgh1 Brain/spinal cord inflammation severity of disease experimental autoimmune encephalomyelitis severity following injection with guinea pig myelin was assayed daily by scoring animals for neurological dysfunction on a scale of 0-4; at17 days post injection, degree of histological disease was measured in brain and spinal cord sections by counting inflammatory foci with 20 or more aggregated mononuclear cells paresis;increased inflammatory response Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 69694 9973459 45696 4 17617956 36592773 1 - by flanking markers 4 17617956 36711313 1 - by flanking markers 60985;60999 BN;LEW F2 LEWxBN
70223 rat Bp57 Blood pressure QTL 57 10 5.0 33891 D10Mit5 35503 D10Rat20 35731 D10Rat33 Blood pressure indirect systolic measured by tail-cuff method at 12 to 16 wks of age increased systemic arterial blood pressure Hypertension 69692 11082136 45648 10 21607719 84443989 1 - by flanking markers 10 21608769 84458228 1 - by flanking markers 10025;10028 MHS/Gib;MNS/Gib F2 MHSxMNS
70224 rat Eae3 Experimental allergic encephalomyelitis QTL 3 10 4.1 33632 D10Mit10 34445 D10Mgh6 34318 D10Mgh10 Brain/spinal cord inflammation severity of disease experimental autoimmune encephalomyelitis severity following injection with guinea pig myelin was assayed daily by scoring animals for neurological dysfunction on a scale of 0-4; at17 days post injection, degree of histological disease was measured in brain and spinal cord sections by counting inflammatory foci with 20 or more aggregated mononuclear cells paresis;increased inflammatory response Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune;Paresis 69694 9973459 45697 10 27184741 45324879 2 - by one flank and peak markers 10 27185630 45326088 2 - by one flank and peak markers 60985;60999 BN;LEW F2 LEWxBN
70225 rat Bp58 Blood pressure QTL 58 1 3.3 36596 D1Rat53 36640 D1Rat14 38028 D1Rat121 Blood pressure direct systolic increased systemic arterial blood pressure Hypertension 69692 11082136 45649 10025;10028 MHS/Gib;MNS/Gib F2 MHSxMNS
70226 rat Eae4 Experimental allergic encephalomyelitis QTL 4 9 36984 D9Rat29 33842 D9Mit6 34264 D9Mgh5 Brain/spinal cord inflammation severity of disease experimental autoimmune encephalomyelitis severity following injection with DA rat spinal cord homogenate and adjuvant was assayed by scoring animals for degree of tail and limb paralysis on a four point scale; severity of disease is defined as maximum score obtained; degree of inflammation was assayed by immunohistochemical analysis of spinal cord infiltrating cells and by in situ detection of IFN-gamma mRNA levels paresis;increased inflammatory response Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 69712 10072499 45698 9 1 22066432 2 - by one flank and peak markers 9 1526958 22067655 1 - by flanking markers 60985;60997 BN;DA F2 DAxBN
71115 rat Niddm15 Non-insulin dependent diabetes mellitus QTL 15 14 4.8 34981 D14Rat23 33953 D14Mit1 33579 D14Mit5 Glucose level plasma glucose homeostasis impaired glucose tolerance;increased circulating glucose level;increased body weight Diabetes Mellitus, Non-Insulin-Dependent 61072 9585427 39279 14 1764386 12386683 1 - by flanking markers 14 1764386 12386732 1 - by flanking markers 61014;70509 OLETF;F344/N F2 OLETFxF344
71116 rat Niddm16 Non-insulin dependent diabetes mellitus QTL 16 X 7.81 34405 DXMgh2 Glucose level increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent 70858;619678 7607056;10373320 3225 Odb1 34243 X 36612231 81612231 3 - by peak only X 36665700 81665700 3 - by peak only 60985;61014 BN;OLETF F2;backcross OLETFxBN
71117 rat Niddm17 Non-insulin dependent diabetes mellitus QTL 17 14 2.35 11030 D14Mit4 10113 D14Mit2 11030 D14Mit4 Glucose level plasma glucose plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered to 30 week old male rats impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 70861 8702404 3226 Odb2 34244 14 22520291 67520291 3 - by peak only 14 22425608 67425608 3 - by peak only 60985;61014 BN;OLETF F2 OLETFxBN
71118 rat Thym1 Thymus enlargement QTL 1 1 10.17 0.001 33571 D1Mit6 10952 D1Wox21 11201 D1Mgh11 Gland mass thymus thymus hyperplasia Thymus Hyperplasia 70859 10792781 3871 Tlag1_mapped 34480 1 141471946 186471946 4 - by one flank marker only 1 141621827 186621827 4 - by one flank marker only 61118;61119 BUF/Mna;WKY/NCrlCrlj F1;backcross WKY/NCrjxBUF/Mna
71119 rat Thym2 Thymus enlargement QTL 2 13 3.8 10205 D13Mgh17 3804 Syt2 41967 D13Arb10 Gland mass thymus thymus hyperplasia Thymus Hyperplasia 70859;634747 10792781;8672128 34481 13 47699094 88282502 1 - by flanking markers 13 47713137 88471386 1 - by flanking markers 61118;61119 BUF/Mna;WKY/NCrlCrlj F1;backcross WKY/NCrjxBUF/Mna
71120 rat Niddm21 Non-insulin dependent diabetes mellitus QTL 21 8 3.73 10435 D8Mgh7 36039 D8Rat58 34723 D8Mgh9 Glucose level postprandial plasma glucose levels were determined using the oral glucose tolerance test (OGTT) administered after overnight fasting; levels were measured at time 0 for fasting glucose and at 30 min intervals until 120 min post OGTT administration; glucose level over the entire time course was calculated as an area under the curve (AUC) of the glucose levels from 0 to 120 min impaired glucose tolerance;increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 2300331;61021;625760 18421176;10051320;12420133 45191 8 3039822 61462321 1 - by flanking markers 8 3039894 61481375 1 - by flanking markers 69643;734526;1302713 F344/DuCrlCrlj;OLETF/Got;F344.OLETF-(D8Rat58-D8Mgh17)/Tj F2 OLETF/OtkxF344/Crj
71111 rat Iddm8 Insulin dependent diabetes mellitus QTL 8 6 1.9 0.002 10507 D6Mgh2 2880 Ighe 10507 D6Mgh2 Insulin level decreased circulating insulin level Diabetes Mellitus, Insulin-Dependent 61077;61480 9571179;9892222 41097 6 110581307 147636619 3 - by peak only 6 133087422 138270304 1 - by flanking markers 61107;61110;631699 BB/OK;SHR/Mol;BB.SHR-(D6Rat184-D6Rat101) F1;backcross BB/OKxSHR/Mol
71112 rat Niddm13 Non-insulin dependent diabetes mellitus QTL 13 1 6.0 1.0E-4 35457 D1Rat90 33903 D1Mit7 33694 D1Mit8 Body weight increased body weight;increased circulating glucose level;increased body weight Diabetes Mellitus, Non-Insulin-Dependent 61072;619678 9585427;10373320 additive Niddm42 39277 1 240980321 267110921 1 - by flanking markers 1 241163920 267322011 1 - by flanking markers 60985;61014;1642689 BN;OLETF;BN.OLETF-(D1Rat169-D1Rat90)/Got F2;intercross OLETFxBN
71113 rat Cari2 Carrageenan-induced inflammation QTL 2 2 2.7 0.009 33983 D2Mit23 34461 D2Mgh12 10582 D2Mit12 Carrageenan-induced inflammation abnormal inflammatory response Hyperglycemia 70860;69693;61072 11306811;10087293;9585427 recessive 45673 2 146659370 210636169 1 - by flanking markers 2 146609297 210598923 1 - by flanking markers 60999;70509 LEW;F344/N F2;intercross F344xLEW
71114 rat Niddm14 Non-insulin dependent diabetes mellitus QTL 14 7 4.5 10431 D7Wox18 Glucose level plasma glucose homeostasis increased body weight;increased circulating glucose level Hyperglycemia;Diabetes Mellitus, Non-Insulin-Dependent 61072 9585427 39278 7 90478161 135478161 3 - by peak only 7 90512391 135512391 3 - by peak only 61014;70509 OLETF;F344/N F2 OLETFxF344
619613 rat Bp77 Blood pressure QTL 77 1 0.01 10165 D1Wox34 36566 D1Rat55 Blood pressure blood pressure measured by indirect tail-cuff method and directly through an aortic catheter increased systemic arterial blood pressure Hypertension 1625015;70855 17332427;11509479 62086 Acsm3 1 168382195 170489972 1 - by flanking markers 1 168492858 170609906 1 - by flanking markers 631589;631590;1641858;1643002 SHR.WKY-(D1Wox34-D1Rat164)/Njs;SHR.WKY-(D1Wox34-Sah)/Njs;SHR.WKY-(D1Rat420-D1Rat278)/Njs;SHR.WKY-(D1Rat420-D1Got161)/Njs F2;intercross SHRxWKY;WKY.SHR-SaxSHR.WKY-Sa
619614 rat Bp78 Blood pressure QTL 78 1 0.001 36454 D1Rat56 36239 D1Rat111 Blood pressure blood pressure measured by indirect tail-cuff method and directly through an aortic catheter increased systemic arterial blood pressure Hypertension 1625015;70855 17332427;11509479 62086 Acsm3 1 172926151 202350882 1 - by flanking markers 1 173062260 202510598 1 - by flanking markers 631591;631592 WKY.SHR-(D1Rat56-D1M7Mit206)/Njs;WKY.SHR-(D1Rat236-D1M7Mit206)/Njs F2;intercross SHRxWKY;WKY.SHR-SaxSHR.WKY-Sa
619615 rat Bp80 Blood pressure QTL 80 13 0.0354 34029 D3Mit1 2168 Atp1a2 11230 D13Uwm1 Blood pressure systolic increased systemic arterial blood pressure Hypertension 70857 9299556 3554 Ren dominant 61107;61110 BB/OK;SHR/Mol F2;backcross SHR/MolxBB/OK
619616 rat Bp79 Blood pressure QTL 79 4 0.0292 2901 Il6 11015 D4Mit24 60732 D4Mit6 Blood pressure systolic increased systemic arterial blood pressure Hypertension 61035;70857 9780220;9299556 3197 Npy dominant 4 456799 78039637 1 - by flanking markers 4 456798 78315767 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol F2;backcross SHR/MolxBB/OK
619617 rat Bp283 Blood pressure QTL 283 17 2.61 0.002 35505 D17Rat54 Blood pressure systolic increased systemic arterial blood pressure Hypertension 70856 11053483 45970 10000;10015 ACI/N;FHH/Eur F2 FHH/EurxACI
619618 rat Rf3 Renal disease susceptibility QTL 3 3 6.5 0.001 33808 D3Mit4 Renal function urine albumin level urine albumin levels were determined colorimetrically using bromocresol-green in urine collected 8 weeks after unilateral nephrectomy glomerulosclerosis;proteinuria Kidney Failure, Chronic 70856 11053483 3 108688653 153688653 3 - by peak only 3 108594227 153594227 3 - by peak only 10000;10015 ACI/N;FHH/Eur F2 FHH/EurxACI
619619 rat Rf4 Renal disease susceptibility QTL 4 14 4.1 0.002 34479 D14Mgh7 Renal function urine albumin level urine protein levels were determined colorimetrically using pyrogallol red/molybdate complex in urine collected 8 weeks after unilateral nephrectomy glomerulosclerosis;proteinuria Kidney Failure, Chronic 1582571;70856 16837819;11053483 14 1 34067237 3 - by peak only 14 0 34067237 3 - by peak only 10000;10015 ACI/N;FHH/Eur F2 FHH/EurxACI
619620 rat Rf5 Renal disease susceptibility QTL 5 17 2.99 0.001 36331 D17Mit12 Renal function urine albumin level urine protein levels were determined colorimetrically using pyrogallol red/molybdate complex in urine collected 8 weeks after unilateral nephrectomy proteinuria;glomerulosclerosis Kidney Failure, Chronic 1582571;70856 16837819;11053483 17 40292859 85292859 3 - by peak only 10000;10015 ACI/N;FHH/Eur F2 FHH/EurxACI
631260 rat Tcas2 Tongue tumor susceptibility QTL 2 1 4.5 34326 D1Mgh21 34244 D1Mgh10 33753 D1Mit5 Tongue tumor susceptibility Tongue Neoplasms 631169 12448007 1 197423292 204280406 1 - by flanking markers 1 197573284 204433956 1 - by flanking markers 60997;61007 DA;WF intercross DAxWF
631261 rat Tcas3 Tongue tumor susceptibility QTL 3 4 6.0 33905 D4Mit11 3186 Nos3 Tongue tumor susceptibility Tongue Neoplasms 631169 12448007 4 6179441 91330582 1 - by flanking markers 4 6179441 91575008 1 - by flanking markers 60997;61007 DA;WF intercross WFxDA
631262 rat Tcas4 Tongue tumor susceptibility QTL 4 14 60762 D14Wox10 11030 D14Mit4 Tongue tumor susceptibility Tongue Neoplasms 631169 12448007 14 19141961 45020354 1 - by flanking markers 14 19141961 44925828 1 - by flanking markers 60997;61007 DA;WF intercross DAxWF
631263 rat Cm24 Cardiac mass QTL 24 5 3.5 18.6 40376 D5Rat173 11001 D5Wox10 39168 D5Rat99 Cardiac mass left ventricle LV (including the septal wall) was blotted dry and weighed individually. LVM was determined by the ratio of LV weight/Body weight heart left ventricle hypertrophy Hypertrophy, Left Ventricular 619659 11157676 3193 Nppa codominant 45969 5 150310201 165073513 2 - by one flank and peak markers 5 150320093 165083701 2 - by one flank and peak markers 631275;631276;1579699 WKY/Cfd;WKHA/Cfd;WKY.WKHA-(D5Rat45-D5Rat245)/Cfd intercross WKY/CfdxWKHA/Cfd
631264 rat Scl22 Serum cholesterol level QTL 22 18 6.2 3916 Ttr 2741 Nr3c1 3916 Ttr Lipid level cholesterol increased circulating cholesterol level Hypercholesterolemia 61055 9199194 18 12406571 32459145 1 - by flanking markers 18 12433216 32494411 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol intercross BB/OKxSHR/Mol
631265 rat Iresp1 Immunoglobin response QTL1 20 8.3 17.0 34260 D20Mgh5 45676 D20Got13 37872 D20Rat31 Anti-DNA antibody level F2 rats were injected subcutaneously with 20 mg/Kg body weights of Atps (aurothiopropanol sulfonate) three time a week for 5 weeks increased IgG level;increased susceptibility to type II hypersensitivity reaction Hypersensitivity 619646 10898507 additive 20 9301974 13963223 1 - by flanking markers 20 9302201 13963450 1 - by flanking markers 631593;631594 LEW/Rj;BN/Rj intercross LEW/RjxBN/Rj
631266 rat Bp132 Blood pressure QTL 132 2 5.0E-4 2633 Fst 34461 D2Mgh12 Blood pressure systolic systolic, diastolic, and mean arterial blood pressure measured in a congenic strain SHRSP/Gla.WKY/Gla-(Fst-D2Mgh12)/Gla and compared to blood pressure of the parental strain SHRSP/Gla increased systemic arterial blood pressure;increased systemic arterial blood pressure Hypertension 2301356;619621;68910 18819818;10406815;10642295 2071;2167;2263;1306589 Agtr1b;Atp1a1;Camk2d;Gca Bp13, Bp14;Bp14 2 46542246 210636169 1 - by flanking markers 2 46470478 210598923 1 - by flanking markers 631278 SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc congenic SS/JrxSR/Jr
631267 rat Cia20 Collagen induced arthritis QTL 20 10 3.2 61274 D10Arb20 61275 D10Arb22 44839 D10Wox7 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint swelling Arthritis, Rheumatoid 631168 11003387 recessive Cia5, Cia21, Cia22, Cia23;Cia21 10 24006429 110718848 2 - by one flank and peak markers 10 24007478 110733352 2 - by one flank and peak markers 10008 BN/SsNHsd intercross
631268 rat Cia21 Collagen induced arthritis QTL 21 10 3.1 33585 D10Mit6 61275 D10Arb22 36749 D10Rat19 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint swelling Arthritis, Rheumatoid 631168 11003387 Cia5, Cia20, Cia22, Cia23;Cia20 10 14721135 110718848 2 - by one flank and peak markers 10 14721056 110733352 2 - by one flank and peak markers 10008 BN/SsNHsd
631269 rat Cia22 Collagen induced arthritis QTL 22 10 8.9 34053 D10Mit3 61275 D10Arb22 34485 D10Mgh4 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint swelling Arthritis, Rheumatoid 631168 11003387 Cia5, Cia20, Cia21, Cia23;Cia23 10 41339689 110718848 2 - by one flank and peak markers 10 41353313 110733352 2 - by one flank and peak markers 10008;631182 BN/SsNHsd;DA/BklArbN
631270 rat Cia23 Collagen induced arthritis QTL 23 10 3.9 34053 D10Mit3 61275 D10Arb22 34485 D10Mgh4 Joint/bone inflammation type II collagen induced arthritis severity was measured via a scoring system for cartilage surface area and joint size; joints were measured twice weekly for six weeks following type II collagen injection joint swelling Arthritis, Rheumatoid 631168 11003387 Cia5, Cia20, Cia21, Cia22;Cia22 10 41339689 110718848 2 - by one flank and peak markers 10 41353313 110733352 2 - by one flank and peak markers 10008;631182 BN/SsNHsd;DA/BklArbN
631271 rat Cati1 Cataract Ihara QTL 1 8 0.001 36291 D8Rat55 2458 Cyp1a1 Cataract susceptibility the eyes of all the animals were examined from one month after birth for the existence of cataract corneal opacity Corneal Opacity 68701 11252169 recessive 8 16468237 61468237 4 - by one flank marker only 8 7238743 61487291 1 - by flanking markers 631285;631286 IER/Ihr;WKY/Izm intercross IExWKY/Izm
631272 rat Lanf1 Left ventricular atrial natriuretic factor QTL 1 5 12.0 44.3 39168 D5Rat99 42770 D5Rat245 41070 D5Rat180 Atrial natriuretic factor concentration left ventricular LV apex (1200 mg) were processed in a volume of 2 mL of 0.2 mol/L acetic acid. The extracts were then centrifuged and aliquots of supernatant were assayed increased circulating atrial natriuretic factor Hypertrophy, Left Ventricular 619659 11157676 3193 Nppa codominant Lvm3 5 157691737 173096209 2 - by one flank and peak markers 5 157701777 173106704 2 - by one flank and peak markers 631275;631276 WKY/Cfd;WKHA/Cfd intercross WKY/CfdxWKHA/Cfd
631273 rat Cati2 Cataract Ihara QTL 2 15 0.001 37308 D15Rat52 34471 D15Mgh3 Cataract susceptibility time of onset the eyes of all the animals were examined from one month after birth for the existence of cataract corneal opacity Corneal Opacity 68701 11252169 recessive 15 16458810 61458810 4 - by one flank marker only 15 16474590 61474590 4 - by one flank marker only 631285;631286 IER/Ihr;WKY/Izm intercross IExWKY/Izm
631274 rat Spl3 Serum phospholipid level QTL 3 18 5.3 33814 D18Mit9 2741 Nr3c1 2715 Gnal Protein level increased circulating total protein level Metabolic Diseases 61055 9199194 18 32459145 80370367 1 - by flanking markers 18 32494411 80443810 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol intercross BB/OK;SHR/Mol
631494 rat Bp95 Blood pressure QTL 95 1 40.0 1.0E-4 62499 D1Uia8 35517 D1Rat18 37598 D1Rat176 Blood pressure systolic measured once a day for four consecutive days by the tail cuff method on conscious restrained rats increased systemic arterial blood pressure Hypertension 68885 11160999 3720 Slc9a3 Bp27;Bp30 631571 SS.LEW-(D1Uia8-D1Mco38)/Jr intercross SSxLEW
631495 rat Bp96 Blood pressure QTL 96 1 4.52 23.9 34662 D1Mgh2 33686 D1Mit11 34037 D1Mit1 Blood pressure systolic measured by the tail cuff method on conscious rats increased systemic arterial blood pressure Hypertension 631172;619642 12441404;9449402 additive 1 22842898 102532417 1 - by flanking markers 1 22845906 102610528 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl intercross SBH/yxSBN/y
631496 rat Bp97 Blood pressure QTL 97 1 3.08 30.0 34381 D1Mgh7 33646 D1Mit4 34011 D1Mit2 Blood pressure systolic measured by the tail cuff method on conscious rats increased systemic arterial blood pressure Hypertension 631172;619642 12441404;9449402 additive 1 106445165 163516043 2 - by one flank and peak markers 1 106523508 163594386 2 - by one flank and peak markers 631572;631573 SBH/Ygl;SBN/Ygl intercross SBH/yxSBN/y
631497 rat Bp98 Blood pressure QTL 98 17 3.66 12.6 34369 D17Mgh4 10348 D17Mit4 34120 D17Mgh5 Blood pressure systolic measured by the tail cuff method on conscious rats increased systemic arterial blood pressure Hypertension 619642 9449402 additive 17 46994933 71214857 2 - by one flank and peak markers 17 46989782 71225690 2 - by one flank and peak markers 631572;631573 SBH/Ygl;SBN/Ygl intercross SBH/yxSBN/y
631498 rat Bp100 Blood pressure QTL 100 5 4.9 0.001 13.5 3193 Nppa 3194 Nppb 3194 Nppb Blood pressure systolic increased systemic arterial blood pressure Hypertension 619655 9171954 5 165063650 165074518 1 - by flanking markers 5 165073838 165084713 1 - by flanking markers 61000;61103 SHR;WKY backcross SHRxWKY
631499 rat Stl1 Serum triglyceride level QTL 1 17 3.6 2091 Aldoc 45450 D17Wox3 34276 D17Mgh2 Lipid level triglyceride increased circulating triglyceride level Hypertriglyceridemia;Arteriosclerosis 619656 11414700 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631500 rat Bp99 Blood pressure QTL 99 2 2.5 6.9 2391 Cpb1 3407 Prlr 2071 Agtr1b Blood pressure systolic measured by the tail cuff method increased systemic arterial blood pressure Hypertension 619650 7852741 2 59701221 105413336 1 - by flanking markers 2 59629454 105358297 1 - by flanking markers 10041;67958 SS/Jr;AS intercross SS/JrxAS
631501 rat Bp101 Blood pressure QTL 101 2 2.4 34461 D2Mgh12 33747 D2Mit10 33747 D2Mit10 Blood pressure systolic measured by the tail cuff method on conscious rats increased systemic arterial blood pressure Hypertension 619656 11414700 dominant 2 155920808 210636008 1 - by flanking markers 2 155870771 210598763 1 - by flanking markers 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631502 rat Cm26 Cardiac mass QTL 26 17 3.71 34989 D17Rat39 35827 D17Rat52 35827 D17Rat52 Cardiac mass left ventricle at 24 wk of age, ventricular mass was determined by removing the whole heart, excising the atria, and dissecting the right ventricular wall from the LV and interventricular septum; ventricles were blotted dry of blood before they were weighed heart left ventricle hypertrophy Hypertrophy, Left Ventricular 619658 11045938 dominant 17 76829512 92594341 1 - by flanking markers 17 76840349 92605174 1 - by flanking markers 631576;631577 LEW/CrlCrlj;SHR/Izm intercross LEW/CrjxSHR/Izm
631503 rat Bp102 Blood pressure QTL 102 7 1.9 2868 Igf1 Blood pressure systolic measured by the tail cuff method on conscious rats increased systemic arterial blood pressure Hypertension 619656 11414700 recessive 7 2068705 47068705 3 - by peak only 7 2089228 47089228 3 - by peak only 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631504 rat Cm27 Cardiac mass QTL 27 7 3.45 35122 D7Rat9 37258 D7Rat107 37642 D7Rat112 Cardiac mass left ventricle at 24 wk of age, ventricular mass was determined by removing the whole heart, excising the atria, and dissecting the right ventricular wall from the LV and interventricular septum; ventricles were blotted dry of blood before they were weighed; mean arterial pressure was measured by direct intra-arterial method in conscious rats increased systemic arterial blood pressure;heart left ventricle hypertrophy Hypertension;Hypertrophy, Left Ventricular 619658 11045938 codominant 7 47865637 125399168 1 - by flanking markers 7 47885908 125433399 1 - by flanking markers 631576;631577 LEW/CrlCrlj;SHR/Izm intercross LEW/CrjxSHR/Izm
631505 rat Bp103 Blood pressure QTL 103 5 3.2 3704 Slc2a1 34248 D5Mgh9 34443 D5Mgh8 Blood pressure systolic measured by the tail cuff method on conscious rats increased systemic arterial blood pressure Hypertension 619656 11414700 recessive 5 139690801 171801867 1 - by flanking markers 5 139696029 171812362 1 - by flanking markers 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631506 rat Bp104 Blood pressure QTL 104 11 2.8 10376 D11Wox6 34112 D11Mgh4 3761 Sst Blood pressure systolic measured by the tail cuff method on conscious rats increased systemic arterial blood pressure Hypertension 619656 11414700 recessive 11 61504311 87759784 2 - by one flank and peak markers 11 61561901 87800381 2 - by one flank and peak markers 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631507 rat Bp105 Blood pressure QTL 105 2 0.001 38626 D2Rat171 67315 D2Arb24 Blood pressure arterial blood pressures measured in conscious, unrestrained male rats increased systemic arterial blood pressure;cardiac hypertrophy Cardiomegaly;Hypertension 619651 11403354 2 116874922 221284686 1 - by flanking markers 2 116819884 221271253 1 - by flanking markers 631578 SHR.BN-(D2Rat171-D2Arb24)/Ipcv intercross
631508 rat Sald1 Serum aldosterone level QTL 1 1 3.7 36640 D1Rat14 Hormone level aldosterone, females serum aldosterone levels were measured in fasting blood samples taken from female 11 week old rats fed a high cholesterol|| high oil diet for 4 weeks increased circulating aldosterone level Arteriosclerosis 629577 12482837 17 1 24981037 3 - by peak only 17 0 24981021 3 - by peak only 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631509 rat Sald2 Serum aldosterone level QTL 2 18 2.9 37568 D18Rat55 35977 D18Rat8 Hormone level aldosterone, females serum aldosterone levels were measured in fasting blood samples taken from female 11 week old rats fed a high cholesterol|| high oil diet for 4 weeks increased circulating aldosterone level Arteriosclerosis 629577 12482837 18 54856551 72450442 1 - by flanking markers 18 54928784 72523556 1 - by flanking markers 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631510 rat Spl2 Serum phospholipid level QTL 2 11 4.1 35096 D11Rat10 Lipid level phospholipid serum phospholipids were measured in fasting blood samples taken from 11 week old rats fed a high cholesterol, high oil diet for 4 weeks hyperlipidemia Arteriosclerosis;Hyperlipidemia 629577 12482837 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631511 rat Pia7 Pristane induced arthritis QTL 7 4 4.3 10158 D4Arb16 34338 D4Mgh11 36143 D4Rat60 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;629560;2324629;629570 18540828;18606636;16804090;12571866;20200546;11090241 recessive Oia2;Cia13;Oia2 45974 4 133939407 171204531 1 - by flanking markers 4 128160777 171449467 2 - by one flank and peak markers 60997;631161;2324631 DA;DXE3/Ztm;DA.E3-(D4Wox49-D4Got136)/Rhd intercross
631512 rat Scl6 Serum cholesterol level QTL 6 1 9.6 35106 D1Rat335 36765 D1Rat27 Lipid level cholesterol baseline serum cholesterol was measured in fasting blood samples taken from 7 week old rats fed a normal (not high fat) diet increased circulating cholesterol level Hypercholesterolemia;Arteriosclerosis 629577 12482837 1 71659707 90282193 1 - by flanking markers 1 71737819 90360304 1 - by flanking markers 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631513 rat Scl7 Serum cholesterol level QTL 7 7 4.1 38198 D7Rat69 Lipid level cholesterol, males baseline serum cholesterol was measured in fasting blood samples taken from 7 week old rats fed a normal (not high fat) diet increased circulating cholesterol level Arteriosclerosis;Hypercholesterolemia 629577 12482837 7 42112079 87112079 3 - by peak only 7 42132809 87132809 3 - by peak only 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631514 rat Scl8 Serum cholesterol level QTL8 2 4.4 34858 D2Rat69 Lipid level cholesterol post high fat dietary serum cholesterol was measured in fasting blood samples taken from 11 week old rats fed a high cholesterol high oil diet for 4 weeks increased circulating cholesterol level Hypercholesterolemia;Arteriosclerosis 629577 12482837 2 224795742 258207540 3 - by peak only 2 224810349 258222147 3 - by peak only 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631515 rat Bw10 Body weight QTL 10 10 3.5 10662 D10Wox23 61296 Abp1 34330 D10Mgh2 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Obesity 619656 11414700 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631516 rat Gluco31 Glucose level QTL 31 15 7.0 34160 D15Mgh5 34471 D15Mgh3 2536 Ednrb Glucose level fasting oral glucose tolerance tests given to male rats to measure fasting and postprandial (30 min after application) plasma glucose levels increased circulating glucose level Hyperglycemia 619656 11414700 15 61458810 102741229 1 - by flanking markers 15 61474590 102757010 1 - by flanking markers 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631517 rat Scl9 Serum cholesterol level QTL 9 16 3.3 35005 D16Rat6 38370 D16Rat44 Lipid level cholesterol post high fat dietary serum cholesterol was measured in fasting blood samples taken from 11 week old rats fed a high cholesterol high oil diet for 4 weeks increased circulating cholesterol level Arteriosclerosis;Hypercholesterolemia 629577 12482837 16 16194598 22671959 1 - by flanking markers 16 16194596 22671957 1 - by flanking markers 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLew/OlaHsd
631518 rat Bw11 Body weight QTL 11 18 2.8 3749 Spink3 45561 D18Wox18 45561 D18Wox18 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Obesity 619656 11414700 18 37135503 82135503 4 - by one flank marker only 18 37168703 82168703 4 - by one flank marker only 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631519 rat Pia11 Pristane induced arthritis QTL 11 1 5.3 13.0 38144 D1Rat185 10951 D1Mit13 34011 D1Mit2 Joint/bone inflammation pristane induced pristane, 150 ul per rat, was injected intradermally at the base of the tail under ether anaesthesia; arthritis development monitored using a microscopic scoring system for each of the four limbs in the entire paw. The maximum total score is thus 16 for each rat by adding up the escores from four paws; rats were observed 1-3 times a week during the experimental period. joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;631225 18606636;16804090;18540828;12111642 recessive Pia9 1 112480604 157480604 3 - by peak only 1 83495981 186621913 2 - by one flank and peak markers 61013;631581 E3;LEW.1F Intercross E3xLEW.1F
631520 rat Bp73 Blood pressure QTL 73 2 1.0E-4 3098 Mme 10584 D2Wox18 Blood pressure systolic increased systemic arterial blood pressure;increased systemic arterial blood pressure Hypertension;Hypertension 631320;70380 12661916;11773968 70972 Hao2 Bp10;Bp19 2 153031724 174727552 1 - by flanking markers 2 152981686 174677658 1 - by flanking markers 631582 SS.WKY-(Mme-D2Wox18)/Mco intercross
631521 rat Pia12 Pristane induced arthritis QTL 12 12 8.9 20.0 35384 D12Rat1 35889 D12Rat10 40986 D12Rat72 Joint/bone inflammation pristane induced pristane, 150 ul per rat, was injected intradermally at the base of the tail under ether anaesthesia; arthritis development monitored using a microscopic scoring system for each of the four limbs in the entire paw; rats were observed 1-3 times a week during the experimental period. joint swelling Arthritis, Rheumatoid 2300074;1582387;631225 18606636;16804090;12111642 recessive Pia4 12 555108 24748499 1 - by flanking markers 12 555108 24611715 1 - by flanking markers 61013;631581 E3;LEW.1F Intercross E3xLEW.1F
631522 rat Bp74 Blood pressure QTL 74 2 0.05 34292 D2Mgh8 34234 D2Mgh9 Blood pressure systolic increased systemic arterial blood pressure Hypertension 70380 11773968 2 179302449 191378271 1 - by flanking markers 2 179252555 191341025 1 - by flanking markers 631583 SS.WKY-(D2Mgh8-D2Mgh9)/Mco intercross
631523 rat Pia13 Pristane induced arthritis QTL 13 14 3.3 8.0 34839 D14Rat32 35723 D14Rat25 37230 D14Rat64 Joint/bone inflammation pristane induced pristane, 150 ul per rat, was injected intradermally at the base of the tail under ether anaesthesia; arthritis development monitored using a microscopic scoring system for each of the four limbs in the entire paw. The maximum total score is thus 16 for each rat by adding up the escores from four paws; rats were observed 1-3 times a week during the experimental period. joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;631225 18606636;16804090;18540828;12111642 recessive 14 43399833 105009429 1 - by flanking markers 14 43402224 105028688 1 - by flanking markers 61013;631581 E3;LEW.1F Intercross LEW.1FxE3
631524 rat Bp75 Blood pressure QTL 75 16 0.05 35475 D16Rat21 42409 D16Rat112 Blood pressure increased systemic arterial blood pressure Hypertension 70460 11919686 16 64959 8413129 1 - by flanking markers 16 64959 8413127 1 - by flanking markers 10000;631585;1358168 ACI/N;SS.LEW-(D16Mit2-D16Rat12)/Ayd;SS.LEW-(D16Mit2-D16Chm23)/Ayd backcross
631525 rat Pia14 Pristane induced arthritis QTL 14 16 4.4 19.0 39390 D16Rat64 60771 D16Wox8 38428 D16Rat53 Joint/bone inflammation pristane induced pristane was injected intradermally at the base of the tail; arthritis development was monitored using a microscopic scoring system for each of the four limbs in the entire paw; maximum total score is thus 16 for each rat by adding up the escores from four paws; rats were observed 1-3 times a week during the experimental period. joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;631225 18540828;18606636;16804090;12111642 recessive Pia11 16 59398206 88891349 1 - by flanking markers 16 59398292 73814480 2 - by one flank and peak markers 61013;631581 E3;LEW.1F Intercross E3xLEW.1F
631526 rat Bp76 Blood pressure QTL 76 10 1.0E-4 66552 D10Mco1 66563 D10Mco6 3185 Nos2 Blood pressure decreased systemic arterial blood pressure;decreased systemic arterial blood pressure Hypertension 619626;619625;61039 9096100;9607182;7537756 10 69986912 102587587 1 - by flanking markers 10 70000535 102601957 1 - by flanking markers 10041;60992 SS/Jr;MNS backcross
631527 rat Tls1 T-lymphoma susceptibility QTL 1 5 3.5 0.001 33981 D5Mit4 11302 D5Mit7 11302 D5Mit7 T-lymphoma susceptibility propylnitrosourea induced T-lymphomas were assayed by both involvement of the thymus and expression of Thy-1.1 antigen on the tumor cells T cell derived lymphoma Lymphoma, T-Cell 619600 10360666 5 94515803 139515803 4 - by one flank marker only 5 94520917 139520917 4 - by one flank marker only 70509;629500 F344/N;LEXF backcross LE/StmxF344
631528 rat Scl11 Serum cholesterol level QTL 11 14 4.9 60764 D14Wox4 2065 Afp 2667 Gc Lipid level cholesterol increased circulating cholesterol level Hypercholesterolemia 619656 11414700 14 19110728 38152541 1 - by flanking markers 14 19110728 38158382 1 - by flanking markers 61110;631574 SHR/Mol;Wild/K backcross WildxSHR/Mol
631529 rat Tls2 T-lymphoma susceptibility QTL 2 7 13.1 0.001 11164 D7Wox24 33648 D7Mit5 33969 D7Mit4 T-lymphoma susceptibility propylnitrosourea induced T-lymphomas were assayed by both involvement of the thymus and expression of Thy-1.1 antigen on the tumor cells T cell derived lymphoma Lymphoma, T-Cell 619600 10360666 7 85090032 137838850 1 - by flanking markers 7 85110762 137915287 1 - by flanking markers 70509;629500 F344/N;LEXF backcross LE/StmxF344
631530 rat Tls3 T-lymphoma susceptibility QTL 3 10 6.7 1.0E-4 34100 D10Mgh3 10948 D10Mgh8 34445 D10Mgh6 T-lymphoma susceptibility propylnitrosourea induced T-lymphomas were assayed by both involvement of the thymus and expression of Thy-1.1 antigen on the tumor cells T cell derived lymphoma Lymphoma, T-Cell 619600 10360666 10 53781298 100090301 1 - by flanking markers 10 53794921 100104671 1 - by flanking markers 70509;629500 F344/N;LEXF backcross LE/StmxF344
631531 rat Iresp2 Immunoglobin response QTL2 10 6.3 13.0 35001 D10Rat43 36179 D10Rat34 44715 D10Wox26 Serum IgE level atps (aurothiopropanol sulfonate) induced F2 rats were injected subcutaneously with 20 mg/Kg body weights of Atps (aurothiopropanol sulfonate) three time a week for 5 weeks increased IgE level Hypersensitivity 619646 10898507 additive 10 23428127 32725718 1 - by flanking markers 10 23429177 32726767 1 - by flanking markers 631593;631594;1331823 LEW/Rj;BN/Rj;LEW.BN-(D10Rat43-D10Rat27)/Rj intercross LEW/RjxBN/Rj
631532 rat Cm50 Cardiac mass QTL 50 10 6.6 60753 D10Wox3 10949 D10Wox11 34053 D10Mit3 Cardiac mass the cardiac mass index (CMI) was calculated by adjusting the heart weight for body weight by regression within each cross; after sacrificed by an overdose of sodium pentobarbital, the total body weight and heart weight of each rat were measured in grams and milligrams, respectively increased heart weight Hypertension 619631 10051321 10 18217625 53793117 1 - by flanking markers 10 28900032 53806740 2 - by one flank and peak markers 10041;60985 SS/Jr;BN intercross BN.SS/Jr
631533 rat Iresp3 Immunoglobin response QTL3 9 16.2 31.0 34264 D9Mgh5 60669 D9Got8 Serum IgE level atps (aurothiopropanol sulfonate) induced F2 rats were injected subcutaneously with 20 mg/Kg body weights of Atps (aurothiopropanol sulfonate) three time a week for 5 weeks increased IgE level Hypersensitivity 619646 10898507 additive Eae4 9 2176482 5446650 2 - by one flank and peak markers 9 2176482 5446650 2 - by one flank and peak markers 631593;631594 LEW/Rj;BN/Rj intercross LEW/RjxBN/Rj
631534 rat Lnnr1 Liver neoplastic nodule remodeling QTL 1 7 3.85 0.001 36099 D7Rat25 Liver neoplastic nodule remodeling frequency calculation of the percentage of liver tumor nodule remodeling is characterized by the presence of irregular nodule margins and irregular GST-P enzyme staining pattern; carried out in livers of rats killed at 32 weeks following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal Rosenthal canal morphology Liver Neoplasms 629574 12672032 2185;2868;3130;3377 Avpr1a;Igf1;Myc;Ppp1cc 7 38076588 83076588 3 - by peak only 7 38097318 83097318 3 - by peak only 60985;70509 BN;F344/N BNxF344
631535 rat Cm51 Cardiac mass QTL 51 10 3.0 10949 D10Wox11 44786 D10Wox6 44773 D10Wox5 Cardiac mass the cardiac mass index (CMI) was calculated by adjusting the heart weight for body weight by regression within each cross; after sacrificed by an overdose of sodium pentobarbital, the total body weight and heart weight of each rat were measured in grams and milligrams, respectively increased heart weight Hypertension 619631 10051321 10 53792967 96585335 2 - by one flank and peak markers 10 53806590 96600452 2 - by one flank and peak markers 10041;60992 SS/Jr;MNS intercross MNS.SS/Jr
631536 rat Lnnr2 Liver neoplastic nodule remodeling QTL 2 1 2.9 5.0E-4 34194 D1Mgh14 Liver neoplastic nodule remodeling frequency calculation of the percentage of liver tumor nodule remodeling is characterized by the presence of irregular nodule margins and irregular GST-P enzyme staining pattern; carried out in livers of rats killed at 32 weeks following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal Rosenthal canal morphology Liver Neoplasms 629574 12672032 2056;2059;2456;1587390 Adra2a;Adrb1;Cyp17a1;Prkg1 recessive 1 241199027 267910886 3 - by peak only 1 241410073 268121971 3 - by peak only 60985;70509 BN;F344/N BNxF344
631537 rat Oia4 Oil induced arthritis QTL 4 10 35513 D10Rat24 11137 D10Wox17 Joint/bone inflammation oil induced degree of arthritis induction is assayed 14 days after subdermal injection of adjuvant oil squalene; assay consists of scoring animals for degree of joint enlargement at four different joints to form a combined score between 0 and 16 joint swelling Arthritis, Rheumatoid 2307198;62404 18540828;11230175 Oia3;Oia5;Oia6 10 79229067 91168491 1 - by flanking markers 10 79243438 91182861 1 - by flanking markers 631596 LEW.1AV1.DA-(D10Rat92-D10Wox17)/Ubc
631538 rat Oia5 Oil induced arthritis QTL 5 10 11137 D10Wox17 34128 D10Mgh1 Joint/bone inflammation oil induced degree of arthritis induction is assayed 14 days after subdermal injection of adjuvant oil squalene; assay consists of scoring animals for degree of joint enlargement at four different joints to form a combined score between 0 and 16 joint swelling Arthritis, Rheumatoid 2307198;62404 18540828;11230175 Oia3;Oia4;Oia6 10 91168332 110718848 4 - by one flank marker only 10 91182702 110733352 4 - by one flank marker only 631597 LEW.1AV1.DA-(D10Wox17-D10Rat135)/Ubc
631539 rat Oia6 Oil induced arthritis QTL 6 10 44836 D10Got154 41584 D10Rat135 Joint/bone inflammation oil induced degree of arthritis induction is assayed 14 days after subdermal injection of adjuvant oil squalene; assay consists of scoring animals for degree of joint enlargement at four different joints to form a combined score between 0 and 16 joint swelling Arthritis, Rheumatoid 2307198;62404 18540828;11230175 Oia4;Oia5;Oia3 10 101532360 108776963 1 - by flanking markers 10 101546731 108791662 1 - by flanking markers 631598 LEW.1AV1.DA-(D10Got154-D10Rat135)/Ubc
631540 rat Bw9 Body weight QTL 9 7 4.5 10075 D7Mgh2 34499 D7Mgh7 10937 D7Wox15 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Obesity 619631 10051321 7 74244786 123665486 2 - by one flank and peak markers 7 74265517 123713215 2 - by one flank and peak markers 10041;60985 SS/Jr;BN intercross BN.SS/Jr
631541 rat Bp81 Blood pressure QTL 81 3 4.0 10668 D3Wox4 43691 D3Wox20 34316 D3Mgh2 Blood pressure systolic measured by the tail cuff method with the animals warmed to 28 C either under light ether anesthesia or in a conscious restrained state increased heart weight;increased systemic arterial blood pressure Hypertension 619631 10051321 3 124893448 171063335 2 - by one flank and peak markers 3 124799021 170969371 2 - by one flank and peak markers 10041;60985 SS/Jr;BN intercross BNxSS/Jr
631542 rat Bp82 Blood pressure QTL 82 10 6.8 33632 D10Mit10 44839 D10Wox7 11480 D10Wox13 Blood pressure systolic measured by the tail cuff method with the animals warmed to 28 C either under light ether anesthesia or in a conscious restrained state increased systemic arterial blood pressure;increased heart weight Hypertension 619631 10051321 10 27184741 103551039 1 - by flanking markers 10 27185630 103565409 1 - by flanking markers 10041;60992 SS/Jr;MNS intercross MNSxSS/Jr
631543 rat Bp83 Blood pressure QTL 83 12 5.8 45014 D12Wox8 33776 D12Mit3 60755 D12Wox16 Blood pressure systolic measured by the tail cuff method with the animals warmed to 28 C either under light ether anesthesia or in a conscious restrained state increased systemic arterial blood pressure Hypertension 619631 10051321 12 16535858 39626712 2 - by one flank and peak markers 12 24295090 39489942 1 - by flanking markers 10041;61103 SS/Jr;WKY intercross MNSxSS/Jr
631544 rat Bp84 Blood pressure QTL 84 1 5.6 21.0 60784 D1Wox29 3750 Spn 34011 D1Mit2 Blood pressure systolic conscious, restrained animals measured by the tail-cuff method increased systemic arterial blood pressure;abnormal baroreceptor physiology Hypertension 2302408;619634 19047583;10604486 1 124614679 186391887 1 - by flanking markers 1 124693023 186541733 1 - by flanking markers 631286;631599 WKY/Izm;SHRSP/Izm intercross SHRSP/IzmxWKY/Izm
631545 rat Bp85 Blood pressure QTL 85 3 3.1 34198 D3Mgh8 34347 D3Mgh16 Blood pressure systolic conscious, restrained animals measured by the tail-cuff method increased systemic arterial blood pressure Hypertension 619634 10604486 3 1 28873394 3 - by peak only 3 0 28873695 3 - by peak only 631286;631599 WKY/Izm;SHRSP/Izm intercross SHRSP/IzmxWKY/Izm
631546 rat Bp86 Blood pressure QTL 86 4 3.2 33757 D4Mit2 33905 D4Mit11 Blood pressure systolic conscious, restrained animals measured by the tail-cuff method increased systemic arterial blood pressure Hypertension 619634 10604486 4 55369931 91330856 1 - by flanking markers 4 55620765 91575281 1 - by flanking markers 631286;631599 WKY/Izm;SHRSP/Izm intercross SHRSP/IzmxWKY/Izm
631547 rat Bp87 Blood pressure QTL 87 10 4.5 34128 D10Mgh1 70513 Gnrhr 33941 D10Mit11 Blood pressure conscious, restrained animals measured by the tail-cuff method increased systemic arterial blood pressure Hypertension 619634 10604486 631286;631599 WKY/Izm;SHRSP/Izm intercross SHRSP/IzmxWKY/Izm
631548 rat Bp88 Blood pressure QTL 88 1 5.0 0.001 36105 D1Rat51 3640 Scnn1b 631293 D1M7Mit236 Blood pressure measured by a radiotelemetric method under anesthesia at 12 weeks of age increased systemic arterial blood pressure Hypertension 619643 10523340 Bp30 1 159782445 180748068 1 - by flanking markers 1 159861463 180887983 1 - by flanking markers 631600 WKY.SHRSP-(Mt1pa-D1Rat200)/Bbb intercross WKYxSHRSP
631549 rat Bp89 Blood pressure QTL 89 1 5.7 36580 D1Rat112 60784 D1Wox29 34011 D1Mit2 Blood pressure increased systemic arterial blood pressure Hypertension 619635 10779121 1 124614852 206574205 1 - by flanking markers 1 124693195 206727659 1 - by flanking markers 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb backcross WKYxSHRSP
631550 rat Bw7 Body weight QTL 7 15 3.6 36313 D15Rat5 40674 D15Rat86 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Obesity 629577 12482837 15 22452603 39869843 1 - by flanking markers 15 22468303 39885610 1 - by flanking markers 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631551 rat Vetf1 Vascular elastic tissue fragility QTL 1 5 5.0 1.0E-4 37784 D5Rat59 37596 D5Rat118 39686 D5Rat119 Vascular lesion number aorta number of elastic tissue lesions was determined by histological analysis of abdominal aorta dissected from 18 wk old rats altered susceptibility to atherosclerosis Arteriosclerosis 619605 11526202 621017 Lyn 5 1368223 5112800 1 - by flanking markers 5 1368224 5112800 1 - by flanking markers 10016;631602 GH/Omr;BN/Elh BN/PitxGH/Omr
631552 rat Vetf2 Vascular elastic tissue fragility QTL 2 10 4.5 2.0E-4 34318 D10Mgh10 10466 D10Mit1 33846 D10Mit2 Vascular lesion number aorta number of elastic tissue lesions was determined by histological analysis of abdominal aorta dissected from 18 wk old rats altered susceptibility to atherosclerosis Arteriosclerosis 619605 11526202 3742 Sparc dominant 10 36254741 95369088 1 - by flanking markers 10 36255791 95383458 1 - by flanking markers 10016;631602 GH/Omr;BN/Elh BN/PitxGH/Omr
631553 rat Bp131 Blood pressure QTL 131 5 4.2 5.0E-4 3193 Nppa Blood pressure increased systemic arterial blood pressure Hypertension 69734 11471055 3193 Nppa 5 165074518 173096209 4 - by one flank marker only 5 165084713 173106704 4 - by one flank marker only 61000;61103 SHR;WKY Backcross SHRxWKY
631554 rat Bp133 Blood pressure QTL 133 10 0.005 3136 Myh11 3185 Nos2 Blood pressure systolic increased systemic arterial blood pressure Hypertension 619633 7568016 dominant Bp1 10 666709 65072453 1 - by flanking markers 10 767179 65086394 1 - by flanking markers 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb backcross WKYxSHRSP
631555 rat Bp134 Blood pressure QTL 134 10 0.001 3177 Ngfr 2686 Gh1 Blood pressure salt-loaded systolic increased systemic arterial blood pressure Hypertension 619633 7568016 dominant Bp1 10 84262804 95694117 1 - by flanking markers 10 84277173 95710261 1 - by flanking markers 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb backcross WKYxSHRSP
631556 rat Bp135 Blood pressure QTL 135 4 0.05 3197 Npy 3753 Spr 3197 Npy Blood pressure measured three times 24 hours after catheterization in conscious animals increased systemic arterial blood pressure Hypertension 631181 8476428 dominant 4 78038013 119369308 1 - by flanking markers 4 78314142 119613765 1 - by flanking markers 631603;631604 WKY/Snk;SHR/Snk intercross WKY/SnkxSHR/Snk
631557 rat Bp136 Blood pressure QTL 136 10 0.003 66469 D10Mco58 35513 D10Rat24 Blood pressure increased systemic arterial blood pressure Hypertension 1643425;628510 18175179;11641286 3185 Nos2 10 34229233 79229233 4 - by one flank marker only 10 34243603 79243603 4 - by one flank marker only 631605 SS.LEW-(D10Arb9-D10Got101)/Jr Intercross
631558 rat Bp137 Blood pressure QTL 137 10 0.013 35627 D10Rat12 66520 D10Mco70 Blood pressure rats at 40 to 42 days of age were fed a 2% NaCl diet and blood pressure was measured by the tail-cuff method on conscious restrained rats on 4 consecutive days starting on the 24th day on the 2% salt diet. increased systemic arterial blood pressure Hypertension 628510 11641286 10 99198838 101355916 1 - by flanking markers 10 99213209 101370286 1 - by flanking markers 631606 SS.MNS-(D10Rat13-D10Mit11)/Jr Intercross
631559 rat Hcuc1 Hepatic copper content QTL 1 10 3.0 Copper level hepatic liver copper concentration (microgram copper per gram dried liver weight) was determined by weighing livers dried overnight at 105 deg after removal from rats at age 11 weeks|| and copper content was assayed using flame atomic absorption spectrophotometry of ashed|| dried tissue dissolved in 6 M HCl increased liver copper level Hepatolenticular Degeneration;Liver Diseases 619607 11741328 621684 Atox1 68049 HXB-1-43 SHR/OlaIpcv||BN-Lx/Cub
631560 rat Apr1 Acute phase response QTL 1 12 6.1 11396 D12Mgh11 Alpha1 acid glycoprotein level pristane induced serum level of alpha1 acid glycoprotein determined on day 14 after subdermal injection of pristane abnormal acute phase protein physiology Arthritis, Rheumatoid 2300074;1582387;2307198;629561 18606636;16804090;18540828;11817600 recessive 12 20418353 46782294 3 - by peak only 12 20281741 46649226 3 - by peak only 60997;61013 DA;E3 E3xDA
631561 rat Hcuc2 Hepatic copper content QTL 2 16 2.8 10885 D16Wox9 Copper level hepatic liver copper content was measured by determining wet weight of the liver at age 11 weeks|| dry weight of the same tissue after drying|| and copper content of the dried tissue was assayed by dissolving the tissue in 6 M HCl and using spectrophotometry increased liver copper level Liver Diseases;Hepatolenticular Degeneration 619607 11741328 16 1 40096622 3 - by peak only 16 0 40096620 3 - by peak only 68049 HXB-1-43 SHR/OlaIpcvxBN-Lx/Cub
631562 rat Apr2 Acute phase response QTL 2 5 3.7 11001 D5Wox10 Alpha1 acid glycoprotein level pristane induced serum level of alpha1 inhibitor 3 determined on day 14 after subdermal injection of pristane abnormal acute phase protein physiology Arthritis, Rheumatoid 2300074;1582387;2307198;629561 18606636;16804090;18540828;11817600 dominant 5 142573432 173096209 3 - by peak only 5 142583620 173106704 3 - by peak only 60997;61013 DA;E3 E3xDA
631563 rat Hcuc3 Hepatic copper content QTL 3 2 3.87 37552 D2Rat185 40128 D2Rat241 Copper level hepatic liver copper concentration was determined dried livers from female rats at age 11 weeks|| and copper content was assayed using spectrophotometry of ashed|| dried tissue increased liver copper level Hepatolenticular Degeneration;Liver Diseases 629572 12094018 2838 Hsd3b5 recessive 2 217985582 238139978 1 - by flanking markers 2 217948644 238126718 1 - by flanking markers 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631564 rat Apr3 Acute phase response QTL 3 10 3.9 10794 D10Mgh9 IL-6 level pristane induced abnormal interleukin-6 physiology Arthritis, Rheumatoid 629561 11817600 additive 10 16579339 61579339 3 - by peak only 10 16587910 61587910 3 - by peak only 60997;61013 DA;E3 E3xDA
631565 rat Hcuc4 Hepatic copper content QTL 4 10 4.15 36203 D10Rat27 38936 D10Rat98 Copper level hepatic liver copper concentration was determined dried livers from male rats at age 11 weeks|| and copper content was assayed using spectrophotometry of ashed|| dried tissue increased liver copper level Liver Diseases;Hepatolenticular Degeneration 629572 12094018 621684 Atox1 recessive Hcuc1 10 70191595 77091834 1 - by flanking markers 10 70205218 77106262 1 - by flanking markers 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLEW/OlaHsd
631566 rat Bp90 Blood pressure QTL 90 2 1.0E-4 61323 D2N35 3098 Mme Blood pressure systolic measured daily for four consecutive days by the tail cuff method on the conscious rats increased systemic arterial blood pressure Hypertension 619640 9541488 2 108114515 153114515 4 - by one flank marker only 2 108064477 153064477 4 - by one flank marker only 631607 SS.WKY-(D2N35-Mme)/Mco backcross SS/JrxWKY
631567 rat Bp91 Blood pressure QTL 91 10 1.0E-4 33941 D10Mit11 Blood pressure systolic measured daily for four consecutive days by the tail cuff method on the conscious rats increased systemic arterial blood pressure Hypertension 619640 9541488 10 56848683 101848683 4 - by one flank marker only 10 56863126 101863126 4 - by one flank marker only 629505 SS.MNS-(D10Mit11-D10M11Mit119)/Mco backcross SS/JrxMNS
631568 rat Bp92 Blood pressure QTL 92 3 2.2 35609 D3Rat53 35947 D3Rat45 35609 D3Rat53 Blood pressure salt-loaded systolic measured on two separate days by the tail cuff method on the ether-anesthetized rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61516 11015598 additive Bp52 3 1 38709732 4 - by one flank marker only 3 0 38606104 4 - by one flank marker only 10041;61000 SS/Jr;SHR intercross SS/JrxSHR
631569 rat Bp93 Blood pressure QTL 93 1 1.0E-4 34381 D1Mgh7 66611 D1Mco36 Blood pressure systolic measured once a day for four consecutive days by the tail cuff method on conscious restrained rats increased systemic arterial blood pressure Hypertension 68885 11160999 additive Bp27;Bp30 1 106445165 122992360 1 - by flanking markers 1 106523508 123070703 1 - by flanking markers 728165 SS.LEW-(D1Rat196-D1Mco36)/Jr intercross SSxLEW
631570 rat Bp94 Blood pressure QTL 94 1 1.0E-4 36432 D1Rat35 38296 D1Rat131 Blood pressure systolic measured once a day for four consecutive days by the tail cuff method on conscious restrained rats increased systemic arterial blood pressure Hypertension 2291850;68885 18324438;11160999 additive Bp27;Bp30 1 124748920 145648920 1 - by flanking markers 1 124827264 145727326 1 - by flanking markers 631610 SS.LEW-(D1Rat39-D1Rat131)/Jr backcross SSxLEW
631198 rat Cm22 Cardiac mass QTL 22 2 4.3 8.0E-4 22.4 33620 D2Mit6 34204 D2Mgh7 34114 D2Mgh15 Cardiac mass left ventricle relative left ventricular mass equals ventricular mass divided by body weight. heart left ventricle hypertrophy Hypertrophy, Left Ventricular 61484 9495256 recessive 45967 2 136313688 156142910 2 - by one flank and peak markers 2 77561812 156092873 1 - by flanking markers 60995;728194 DRY;SHR/N intercross SHRxDRY
631199 rat Cm23 Cardiac mass QTL 23 1 4.6 4.0E-4 24.5 34399 D1Mgh9 34011 D1Mit2 33959 D1Mit3 Cardiac mass left ventricle relative left ventricular mass equals ventricular mass divided by body weight. heart left ventricle hypertrophy Hypertrophy, Left Ventricular 61484 9495256 recessive Lvm1 45968 1 134980682 176854992 1 - by flanking markers 1 135059025 176994239 1 - by flanking markers 60995;728194 DRY;SHR/N intercross SHRxDRY
631200 rat Cm25 Cardiac mass QTL 25 3 4.8 1.0E-4 16.5 35380 D3Rat27 34979 D3Rat38 34918 D3Rat29 Cardiac mass left ventricle the left ventricle and septum were weighed together heart left ventricle hypertrophy Hypertrophy, Left Ventricular 69706 10205229 3439 Ptgs1 dominant Lvm1;Lvm2 3 58882977 87981062 1 - by flanking markers 3 58779349 87877514 1 - by flanking markers 61097;61109 WKY/NCruk;F344/NHsd intercross WKYxF344
631201 rat Panci1 Pancreas inflammation QTL 1 7 17.1 0.001 12.0 35304 D7Rat4 38306 D7Rat97 Pancreas inflammation score pancreatitis measured by histological examination for fibrosis, hemorrhage, inflammatory infiltration, adipose replacement, and edema increased body weight;pancreas inflammation Pancreatitis 619682 11414764 additive 7 123574930 134614033 1 - by flanking markers 7 123608910 134690471 1 - by flanking markers 60985;634367;634369 BN;BN/CrlCrlj;WBN/KobSlc intercross BNxWBN/Kob;BN/CrjxWBN/KobSlc
631202 rat Gluco13 Glucose level QTL 13 1 1.0E-4 0.1 36023 D1Rat38 619844 Cnga4 33959 D1Mit3 Glucose level postprandial fasting rats were administered 2g/kg glucose and blood glucose concentrations measured at times 0, 60 and 120 min. impaired glucose tolerance;increased body weight Diabetes Mellitus, Non-Insulin-Dependent 631173 12705906 Gisdt2;Gisdt3 1 133566530 163141556 1 - by flanking markers 1 133645024 163237158 1 - by flanking markers 60985;631219 BN;SDT/Jcl backcross SDTxBN
631203 rat Gluco14 Glucose level QTL 14 2 1.0E-4 0.1 38466 D2Rat118 38942 D2Rat156 2591 Fabp2 Glucose level postprandial fasting rats were administered 2g/kg glucose and blood glucose concentrations measured at times 0, 60 and 120 min. impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 631173 12705906 2591 Fabp2 Gisdt1;Gisdt3 2 214988814 227924156 1 - by flanking markers 2 214952051 227910896 1 - by flanking markers 60985;631219 BN;SDT/Jcl backcross SDTxBN
631204 rat Gluco15 Glucose level QTL 15 X 0.001 0.08 11236 DXWox11 39154 DXRat83 11494 DXWox20 Glucose level postprandial fasting rats were administered 2g/kg glucose and blood glucose concentrations measured at times 0, 60 and 120 min. impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 631173 12705906 Gisdt1;Gisdt2 X 1 43167410 4 - by one flank marker only X 0 43220879 4 - by one flank marker only 60985;631219 BN;SDT/Jcl backcross SDTxBN
631205 rat Bp196 Blood pressure QTL 196 1 4.0 1.0E-4 34.4 34244 D1Mgh10 34134 D1Mgh1 33959 D1Mit3 Blood pressure mean arterial increased systemic arterial blood pressure Hypertension 61484 9495256 additive 1 119780561 204280278 1 - by flanking markers 1 119858904 204433664 1 - by flanking markers 60995;728194 DRY;SHR/N intercross SHRxDRY
631206 rat Niddm40 Non-insulin dependent diabetes mellitus QTL 40 1 33806 D1Mit24 60788 D1Wox7 33770 D1Mit12 Glucose level postprandial postparandial blood glucose measurment. impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 619671 10902185 1 139026999 167337781 1 - by flanking markers 1 139105405 167448445 1 - by flanking markers 61014;70509 OLETF;F344/N intercross OLETFxF344
631207 rat Niddm41 Non-insulin dependent diabetes mellitus QTL 41 17 34276 D17Mgh2 Glucose level postprandial postparandial blood glucose measurment. impaired glucose tolerance Diabetes Mellitus, Non-Insulin-Dependent 619671 10902185 17 1 43786391 3 - by peak only 17 0 43786391 3 - by peak only 61014;70509 OLETF;F344/N intercross OLETFxF344
631208 rat Bw1 Body weight QTL1 2 5.09 13.8 60793 D2Wox3 34190 D2Mgh19 Body fat amount mesenteric abnormal abdominal fat pad morphology Obesity 619690 11087657 semidominant 2 42882523 84991982 1 - by flanking markers 2 42802970 84936944 1 - by flanking markers 61014;70509 OLETF;F344/N F2 OLETFxF344
631209 rat Bw2 Body weight QTL2 4 4.2 11.3 36476 D4Rat3 35625 D4Rat14 34200 D4Mgh1 Body fat amount retroperitoneal abnormal retroperitoneal fat pad morphology Obesity 619690 11087657 recessive 4 5351609 41729771 1 - by flanking markers 4 5351609 41849418 1 - by flanking markers 61014;70509 OLETF;F344/N F2 OLETFxF344
631210 rat Bw3 Body weight QTL3 8 5.9 34152 D8Mgh17 35717 D8Rat9 34310 D8Mgh4 Body fat amount mesenteric abnormal abdominal fat pad morphology Obesity 619690 11087657 additive 8 73102005 117434131 1 - by flanking markers 8 73121059 117453586 1 - by flanking markers 61014;70509 OLETF;F344/N OLETFxF344
631211 rat Bw4 Body weight QTL4 9 5.31 16.5 35695 D9Rat44 Body fat amount retroperitoneal abnormal retroperitoneal fat pad morphology Obesity 619690 11087657 recessive 9 2948882 47948882 4 - by one flank marker only 9 2948882 47948882 4 - by one flank marker only 61014;70509 OLETF;F344/N OLETFxF344
631212 rat Bw5 Body weight QTL5 14 5.43 12.4 35342 D14Rat8 33953 D14Mit1 60763 D14Wox3 Body fat amount retroperitoneal abnormal retroperitoneal fat pad morphology Obesity 619690 11087657 recessive 14 12386683 32584630 1 - by flanking markers 14 12386732 32584631 1 - by flanking markers 61014;70509 OLETF;F344/N intercross OLETFxF344
631213 rat Bw60 Body weight QTL60 14 4.51 13.8 36512 D14Rat18 35897 D14Rat22 Body fat amount retroperitoneal determined adiposity index, percentage of retroperitoneal fat pad weight/body weight abnormal retroperitoneal fat pad morphology Obesity 619690 11087657 recessive 14 85715836 102509397 1 - by flanking markers 14 85734982 102528608 1 - by flanking markers 61014;70509 OLETF;F344/N intercross OLETFxF344
631214 rat Bw61 Body weight QTL61 1 3.4 1.0E-4 5.0 33903 D1Mit7 37754 D1Rat123 Body fat amount intramuscular musculus longismus was stained with Oil Red O and area was measured. abnormal adipose tissue distribution Obesity 619672 11853145 recessive Obs1;Obs2;Obs3;Obs4;Obs5;Obs6 1 223729371 240980142 1 - by flanking markers 1 223893394 241163531 1 - by flanking markers 61014;70509 OLETF;F344/N intercross F344xOLETF
631215 rat Stl8 Serum triglyceride level QTL 8 1 9.27 1.0E-4 13.6 34009 D1Mit34 35457 D1Rat90 Lipid level triglyceride triglyceride levels were measured in blood taken from tail veins of rats under fasting conditions. increased circulating triglyceride level Hypertriglyceridemia 70852 10644432 Tgl1;Tgl2;Tgl3 1 230963697 267910886 2 - by one flank and peak markers 1 231127720 268121971 2 - by one flank and peak markers 60985;61014 BN;OLETF backcross BNxOLETF
631216 rat Stl9 Serum triglyceride level QTL 9 8 4.71 1.0E-4 7.1 35987 D8Rat30 33858 D8Mit4 33973 D8Mit2 Lipid level triglyceride triglyceride levels were measured in blood from tail veins of rats under fasting conditions. increased circulating triglyceride level Hypertriglyceridemia 70852 10644432 Tgl1;Tgl2;Tgl3;Tgl4 8 44484347 74178405 1 - by flanking markers 8 44493113 74197793 1 - by flanking markers 60985;61014 BN;OLETF backcross BNxOLETF
631217 rat Activ1 Activity QTL 1 8 15.9 35.0 33919 D8Mit15 10169 D8Wox11 34068 D8Mgh11 Activity level novel environment number of interruptions over 60 min. of two horizontal photobeams after placement in a wire cage hyperactivity;increased exploration in new environment Hyperkinesis 631228;631170 12660808;8944030 8 106733287 113479445 2 - by one flank and peak markers 8 106752743 113498899 2 - by one flank and peak markers 60985;61103;68186 BN;WKY;WKHA/N intercross WKYxWKHA
631642 rat Stl2 Serum triglyceride level QTL 2 4 3.3 33656 D4Mit9 2901 Il6 Lipid level triglyceride measured in an automatic analyzer using blood samples obtained by ophthalamic venous plexus puncture in 12 week old males increased circulating triglyceride level Hypertriglyceridemia 619667 9633608 4 461376 54828069 1 - by flanking markers 4 0 461376 4 - by one flank marker only 61107;61110 BB/OK;SHR/Mol SHR/MolxBB/OK
631643 rat Bp120 Blood pressure QTL 120 9 3.0 Blood pressure systolic measured at 13 weeks of age by the tail-cuff method by using the average of three measurements increased systemic arterial blood pressure Hypertension 629623 12569259 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631645 rat Bp121 Blood pressure QTL 121 13 3.3 34351 D13Mgh4 Blood pressure systolic measured at 13 weeks of age by the tail-cuff method by using the average of three measurements increased systemic arterial blood pressure Hypertension 629623 12569259 13 15989872 60989872 3 - by peak only 13 16003915 61003915 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631646 rat Stl4 Serum triglyceride level QTL 4 4 6.5 1.0E-4 17.9 33711 D4Mit5 34001 D4Mit17 Lipid level triglyceride tail vein blood was obtained after overnight starvation and triglyceride concentrations measured increased circulating insulin level;increased circulating triglyceride level Hyperinsulinism;Hypertriglyceridemia 631174 12687333 4 72160227 134858710 1 - by flanking markers 4 72436134 135103551 1 - by flanking markers 1302795 HTG intercross hHTGxBN
631647 rat Bp122 Blood pressure QTL 122 3 6.2 34146 D3Mgh6 Blood pressure salt-loaded systolic measured by the tail-cuff method using the average of three measurements in six month old females after 1 month of salt loading by giving the rats drinking water with 1% NaCl increased systemic arterial blood pressure Hypertension 629623 12569259 3 28022667 73022667 3 - by peak only 3 27919040 72919040 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631648 rat Stl5 Serum triglyceride level QTL 5 8 4.0 3.0E-4 41522 D8Rat164 44441 D8Wox3 33913 D8Mit13 Lipid level triglyceride tail vein blood was obtained after overnight starvation and triglyceride concentrations measured increased circulating triglyceride level Hypertriglyceridemia 631174 12687333 additive 8 28414004 58991068 2 - by one flank and peak markers 8 28414101 59008641 2 - by one flank and peak markers 1302795 HTG intercross hHTGxBN
631649 rat Bp123 Blood pressure QTL 123 3 3.2 34250 D3Mgh12 Blood pressure salt-loaded systolic measured by the tail-cuff method using the average of three measurements in six month old males and females after 1 month of salt loading by giving the rats drinking water with 1% NaCl increased systemic arterial blood pressure Hypertension 629623 12569259 3 89819539 134819539 3 - by peak only 3 89725112 134725112 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631650 rat Stl6 Serum triglyceride level QTL 6 8 4.0 0.0019 36235 D8Rat35 34180 D8Mgh1 34415 D8Mgh6 Lipid level triglyceride tail vein blood was obtained after overnight starvation and triglyceride concentrations measured increased circulating triglyceride level Hypertriglyceridemia 631174 12687333 additive 8 64616911 116844692 1 - by flanking markers 8 64635965 116864147 1 - by flanking markers 1302795 HTG intercross hHTGxBN
631651 rat Bp124 Blood pressure QTL 124 4 3.0 35409 D4Rat34 Blood pressure systolic measured in male rats at age 8 weeks of age by the tail-cuff method increased systemic arterial blood pressure Hypertension 629623 12569259 4 62514126 107514126 3 - by peak only 4 62757598 107757598 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631652 rat Bp106 Blood pressure QTL 106 10 3671 Shbg 2171 Atp1b2 Blood pressure systolic measured after salt loading via radio telemetric transducers implanted in the rat abdominal cavitiy which measured abdominal aortic blood pressure increased systemic arterial blood pressure Hypertension 629620 12566390 10 56424465 56432474 1 - by flanking markers 10 56438088 56446096 1 - by flanking markers 631693;631694;728139 WKY.SHRSP-(Shbg-Atp1b2)/Bbb;WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb;WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb
631653 rat Bp125 Blood pressure QTL 125 8 3.3 33895 D8Mit1 Blood pressure systolic measured at 10 weeks of age by the tail-cuff method increased systemic arterial blood pressure Hypertension 629623 12569259 8 70474667 115474667 3 - by peak only 8 70494123 115494123 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631654 rat Bp107 Blood pressure QTL 107 1 37428 D1Rat200 39314 D1Rat216 Blood pressure systolic measured after salt loading via radio telemetric transducers implanted in the rat abdominal cavitiy which measured abdominal aortic blood pressure increased systemic arterial blood pressure Hypertension 629620 12566390 1 126938969 185923619 1 - by flanking markers 1 127017358 186073500 1 - by flanking markers 631694;728139 WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb;WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb
631655 rat Bp126 Blood pressure QTL 126 15 4.0 2536 Ednrb Blood pressure systolic measured at 10 weeks of age by the tail-cuff method increased systemic arterial blood pressure Hypertension 629623 12569259 15 65395920 109758846 3 - by peak only 15 65411697 109774626 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631656 rat Bp108 Blood pressure QTL 108 9 5.97 1.0E-4 36556 D9Rat10 Blood pressure salt-loaded systolic measured by tail cuff method in 14 week old male rats fed a high salt (4%w/w ) diet from 6 to 14 weeks of age increased systemic arterial blood pressure Hypertension 629621 12775577 9 45992963 90992963 3 - by peak only 9 46139946 91139946 3 - by peak only 631695;631696 SS/JrRkb;SHR/FubRkb SS/JrRkbxSHR/Rkb
631658 rat Cm7 Cardiac mass QTL 7 1 5.32 1.0E-4 36866 D1Rat73 Cardiac mass aorta relative weight of the dissected descending aorta per body weight was measured in samples dissected from rats killed at 15 weeks of age who were fed a high salt (4% w/w) diet from 6 to 14 weeks of age abnormal aortic weight Heart Diseases;Hypertension 629621 12775577 1 201920676 246920676 3 - by peak only 1 202084699 247084699 3 - by peak only 631695;631696 SS/JrRkb;SHR/FubRkb SS/JrRkbxSHR/Rkb
631660 rat Hcar1 Hepatocarcinoma resistance QTL 1 10 3.4 1.0E-4 34318 D10Mgh10 38062 D10Rat96 36542 D10Rat51 Liver tumor resistance nodule volume neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 619598 10493520 3112;3889 Abcc1;Tp53 dominant 10 6172805 36254741 1 - by flanking markers 10 6172805 36255791 1 - by flanking markers 60985;70509 BN;F344/N BNxF344
631662 rat Hcar2 Hepatocarcinoma resistance QTL 2 4 3.1 3.0E-4 11011 D4Mgh4 36554 D4Rat47 35817 D4Rat40 Liver tumor resistance nodule volume neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 619598 10493520 2794;3082;3849 Hgf;Met;Tgfa 4 78035196 135074488 2 - by one flank and peak markers 4 78311326 135287320 2 - by one flank and peak markers 60985;70509 BN;F344/N BNxF344
631663 rat Bw6 Body weight QTL 6 7 3.4 39048 D7Rat94 35921 D7Rat12 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Obesity 629577 12482837 7 142816042 143002779 4 - by one flank marker only 7 142896232 143082968 4 - by one flank marker only 10004;631579 BC/CpbU;LEW/OlaHsd BC/CpbuxLew/OlaHsd
631664 rat Hcar3 Hepatocarcinoma resistance QTL 3 8 2.9 5.0E-4 36161 D8Rat36 11222 D8Mgh3 34870 D8Rat18 Liver tumor resistance nodule volume neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 619598 10493520 2458;2459;3845 Cyp1a1;Cyp1a2;Tf 8 57308572 103684785 1 - by flanking markers 8 57327627 103704240 1 - by flanking markers 60985;70509 BN;F344/N BNxF344
631665 rat Bw8 Body weight QTL 8 3 5.5 11499 D3Wox23 11261 D3Wox9 34242 D3Mgh13 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Obesity 619631 10051321 3 47722501 171063335 2 - by one flank and peak markers 3 89725091 134725091 3 - by peak only 10041;60992 SS/Jr;MNS intercross MNS.SS/Jr
631666 rat Iddm5 Insulin dependent diabetes mellitus QTL 5 X Insulin level increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 625443 8586150 60997;61107 DA;BB/OK
631667 rat Iddm6 Insulin dependent diabetes mellitus QTL 6 1 Insulin level increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 625443 8586150 60997;61107 DA;BB/OK
631668 rat Iddm7 Insulin dependent diabetes mellitus QTL 7 X Insulin level increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 631165 9080298 631697;631698 BBDP/Hri;BN/Mol BB-DP/HrixBN/Mol
631669 rat Iddm9 Insulin dependent diabetes mellitus QTL 9 1 2.8 0.039 10674 D1Mgh12 33844 D1Mit14 10805 D1Mgh13 Insulin level measured by puncturing the opthalmic venous plexus every two weeks from age 12 weeks to 34 weeks in non-diabetics and until diabetes onset in diabetics increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 619674;61077 9858659;9571179 1 247322146 266002939 1 - by flanking markers 1 247436621 266213984 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol backcross BB/OKxSHR/Mol
631670 rat Iddm10 Insulin dependent diabetes mellitus QTL 10 1 1.9 62086 Acsm3 3643 Sct 3750 Spn Insulin level measured by puncturing the opthalmic venous plexus every two weeks from age 12 weeks to 34 weeks in non-diabetics and until diabetes onset in diabetics increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 619674 9858659 1 178054386 201472944 1 - by flanking markers 1 178212017 201623978 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol BB/OKxSHR/Mol
631671 rat Iddm11 Insulin dependent diabetes mellitus QTL 11 4 3.6 43795 D4Wox10 11012 D4Wox22 33711 D4Mit5 Insulin level increased circulating glucose level;pancreas inflammation Diabetes Mellitus, Insulin-Dependent 1600776;61480 17376830;9892222 4 56920444 78042833 1 - by flanking markers 4 57196574 78318963 1 - by flanking markers 10002;61007 BBDP/Rhw;WF WFxBB/DF
631672 rat Iddm12 Insulin dependent diabetes mellitus QTL 12 13 2.2 0.0032 33923 D13Mit1 34371 D13Mgh3 34076 D13Mgh1 Insulin level increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 61480 9892222 2199 Bcl2 13 1 25430276 2 - by one flank and peak markers 10002;61007 BBDP/Rhw;WF WFxBB/DF
631673 rat Iddm13 Insulin dependent diabetes mellitus QTL 13 3 1.1 0.014 33808 D3Mit4 34240 D3Mgh1 10502 D3Mgh10 Insulin level increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 61480 9892222 3 131188558 163778754 1 - by flanking markers 3 131094132 163684916 1 - by flanking markers 10002;61007 BBDP/Rhw;WF
631674 rat Iddm14 Insulin dependent diabetes mellitus QTL 14 4 42164 D4Arb29 10524 D4Mit3 Insulin level increased circulating glucose level Diabetes Mellitus, Insulin-Dependent 1358925;2305928;1600776;1358924;1304485;61480;2313174;61479 14727142;19205800;17376830;15793267;12401717;9892222;19720792;10535446 4 63276741 160891592 1 - by flanking markers 4 63552871 161136528 1 - by flanking markers 10003;61007;1357172;1357176;1357187;1357192;1357193;1357194;1357196;1641852;1641868;1641878 BBDR/Rhw;WF;WF.BBDR-(D4Arb29-D4Rat44)/Wor;WF.BBDR-(D4Arb29-D4Rat96)/Wor;WF.BBDR-(D4Rat16-D4Got39)/Wor;WF.BBDR-(D4Got39-D4Rat44)/Wor;WF.BBDR-(D4Got51-D4Rat44)/Wor;WF.BBDR-(D4Rat96-D4Rat44)/Wor;WF.BBDR-(D4Arb29-D4Rat265)/Wor;WF.BBDR-(D4Got48-D4Got43)/Wor;WF.BBDR-(D4Rat93-D4Rat228)/Wor;WF.BBDR-(Clcn1-D4Rat228)/Wor BB/DRxWF
631675 rat Iddm15 Insulin dependent diabetes mellitus QTL 15 18 Insulin level rats were diagnosed as diabetic if exhibited glycosuria as measured by Diabur-Test 5000 and displayed a blood glucose concentration of >300mg/dl on two consecutive days decreased circulating glucose level;decreased urine glucose level Diabetes Mellitus 619685 11327715 631700 BB.SHR-(Gnal-D18Mit9) BB/OKxSHR
631676 rat Cm8 Cardiac mass QTL 8 3 7.03 1.0E-4 34336 D3Mgh7 Cardiac mass aorta relative weight of the dissected descending aorta per body weight was measured in samples dissected from rats killed at 15 weeks of age who were fed a high salt (4% w/w) diet from 6 to 14 weeks of age abnormal aortic weight Hypertension;Heart Diseases 629621 12775577 3 14056777 59056777 3 - by peak only 3 13953150 58953150 3 - by peak only 631695;631696 SS/JrRkb;SHR/FubRkb SS/JrRkbxSHR/Rkb
631677 rat Iddm16 Insulin dependent diabetes mellitus QTL 16 6 Insulin level decreased circulating insulin level Diabetes Mellitus, Insulin-Dependent 61077 9571179 60997;61107 DA;BB/OK backcross BB/OKxDA
631678 rat Cm9 Cardiac mass QTL 9 19 4.27 1.0E-4 35567 D19Rat18 Cardiac mass aorta relative weight of the dissected descending aorta per body weight was measured in samples dissected from rats killed at 15 weeks of age who were fed a high salt (4% w/w) diet from 6 to 14 weeks of age abnormal aortic weight Hypertension;Heart Diseases 629621 12775577 Bp114 19 1 29295214 3 - by peak only 19 0 29300041 3 - by peak only 631695;631696 SS/JrRkb;SHR/FubRkb SS/JrRkbxSHR/Rkb
631679 rat Cm10 Cardiac mass QTL 10 3 7.34 1.0E-4 34186 D3Mgh9 Cardiac mass left ventricle relative weight of the left ventricle (including septum) per body weight was measured in samples dissected from rats killed at 15 weeks of age who were fed a high salt (4% w/w) diet from 6 to 14 weeks of age heart left ventricle hypertrophy Hypertrophy, Left Ventricular;Hypertension 629621 12775577 3 1 26510302 3 - by peak only 3 0 26510302 3 - by peak only 631695;631696 SS/JrRkb;SHR/FubRkb SS/JrRkbxSHR/Rkb
631680 rat Cm11 Cardiac mass QTL 11 9 3.1 8.9E-4 39812 D9Rat125 Cardiac mass left ventricle relative weight of the left ventricle (including septum) per body weight was measured in samples dissected from rats killed at 15 weeks of age who were fed a high salt (4%w/w) diet from 6 to 14 weeks of age heart left ventricle hypertrophy Hypertrophy, Left Ventricular;Hypertension 629621 12775577 9 17330701 62330701 3 - by peak only 9 17332115 62332115 3 - by peak only 631695;631696 SS/JrRkb;SHR/FubRkb SS/JrRkbxSHR/Rkb
631681 rat Cm12 Cardiac mass QTL 12 19 3.33 5.3E-4 35567 D19Rat18 Cardiac mass left ventricle relative weight of the left ventricle (including septum) per body weight was measured in samples dissected from rats killed at 15 weeks of age who were fed a high salt (4% w/w) diet from 6 to 14 weeks of age heart left ventricle hypertrophy Hypertension;Hypertrophy, Left Ventricular 1600252;2307185;629621 17143179;18824493;12775577 Bp111 19 1 29295214 3 - by peak only 19 0 29300041 3 - by peak only 631695;631696 SS/JrRkb;SHR/FubRkb SS/JrRkbxSHR/Rkb
631682 rat Bp115 Blood pressure QTL 115 2 4.3 1.0E-4 66484 D2Uia17 Blood pressure salt-loaded systolic measured 3 times per animal over a 5 day period by tail cuff method in 188 male rats who were fed a high salt diet (8% NaCl) for a period of 5 weeks starting from 37 days of age increased systemic arterial blood pressure Hypertension 629622 12473864 2845;3043;3329;69413 Htr1a;Map1b;Pik3r1;Rasgrf2 additive 2 1 35849844 3 - by peak only 2 0 35770213 3 - by peak only 10041;67958 SS/Jr;AS SS/JrxAS
631827 rat Alc4 Alcohol consumption QTL 4 5 3.5 3.0 40718 D5Rat120 39756 D5Rat123 34387 D5Mgh17 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 724636;631230 12960747;10979603 additive 5 10517466 18944220 2 - by one flank and peak markers 5 10517466 18944220 2 - by one flank and peak markers 631844;631845;731187 HAD1;LAD1;HAD2 Intercross HDA1 x LDA1, HAD2 x LAD2;HAD2xLAD2
631828 rat Alc5 Alcohol consumption QTL 5 10 2.4 2.0 34361 D10Mgh25 41276 D10Rat182 34361 D10Mgh25 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 724636;4890458;631230 12960747;20705418;10979603 2401;61836;1304560;1311614;1359733;1563691 Crebbp;Clcn7;Fahd1;Gnptg;Trap1;Mapk8ip3 additive 10 5090008 17515458 1 - by flanking markers 10 5090008 17516507 1 - by flanking markers 631844;631845;731187;731188 HAD1;LAD1;HAD2;LAD2 Intercross;intercross HAD1xLAD1;HAD2xLAD2
631829 rat Alc6 Alcohol consumption QTL 6 12 4.7 4.0 41626 D12Rat93 34389 D12Mgh10 36490 D12Rat18 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 631230 10979603 additive 12 29675888 39018219 1 - by flanking markers 12 29539264 38881607 1 - by flanking markers 631844;631845 HAD1;LAD1 intercross HAD1xLAD1
631830 rat Alc7 Alcohol consumption QTL 7 16 2.9 33848 D16Mit2 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 724636;631230 12960747;10979603 additive 16 1 26804456 3 - by peak only 16 0 26804454 3 - by peak only 631844;631845 HAD1;LAD1 Intercross HAD1xLAD1
631831 rat Alc8 Alcohol consumption QTL 8 3 2.7 33782 D3Mit10 38148 D3Rat82 33782 D3Mit10 Consumption level alcohol preference individually housed rats with free access to 10% ethanol solution (v/v) and water for three weeks; consumed amount was measured twice a week; average the six drinking scores from adjusted body weight (g/kg/day) alcohol preference Alcoholism 631229 11958543 3 1 29749474 4 - by one flank marker only 3 13005845 29645846 1 - by flanking markers 634380;634381 P;NP Intercross W
631832 rat Sach1 Saccharin preference QTL 1 3 2.7 0.02 3.3 37010 D3Rat49 36472 D3Rat44 36047 D3Rat46 Consumption level saccharin preference measure intake (0.1% w/v saccharin solution) per day with adjusted body weight (ml/kg body weight/day) during a 48-h preference test; test it four weeks following the completion of the measure of the alcohol phenotypes saccharin preference;saccharin versus water Alcoholism 631229 11958543 3 23762471 41420436 1 - by flanking markers 3 23658844 41316808 1 - by flanking markers 634380;634381 P;NP Intercross W
631833 rat Sach2 Saccharin preference QTL 2 16 2.5 0.02 5.0 34066 D16Mgh1 37054 D16Rat17 34553 D16Mgh6 Consumption level saccharin preference measure intake (0.1% w/v saccharin solution) per day with adjusted body weight (ml/kg body weight/day) during a 48-h preference test; test it four weeks following the completion of the measure of the alcohol phenotypes saccharin preference;saccharin versus water 631229 11958543 additive 16 46137355 53486191 1 - by flanking markers 16 46137430 53486309 1 - by flanking markers 634380;634381 P;NP Intercross W
631834 rat Sach3 Saccharin preference QTL 3 18 3.9 0.01 3.0 39000 D18Rat61 34975 D18Rat13 39000 D18Rat61 Consumption level saccharin preference, males measured intake (0.1% w/v saccharin solution) per day with adjusted body weight (ml/kg body weight/day) during a 48-h preference test; test it four weeks following the completion of the measure of the alcohol phenotypes saccharin preference;saccharin versus water 631229 11958543 recessive 18 39071649 84071649 3 - by peak only 18 39144851 84144851 3 - by peak only 634380;634381 P;NP Intercross W
631835 rat Niddm33 Non-insulin dependent diabetes mellitus QTL 33 1 4.27 1.16E-5 16.1 40126 D1Rat306 Lipid level cholesterol increased circulating cholesterol level;abnormal lateral ganglionic eminence morphology Hypercholesterolemia;Obesity 619669 11071303 2915 Ins1 Niddm13, Niddm42, Niddm45 1 226083572 267910886 3 - by peak only 1 226343481 268121971 3 - by peak only 10008;69643;734526 BN/SsNHsd;F344/DuCrlCrlj;OLETF/Got backcross F344/NHsdxBN/SsNHsd
631836 rat Niddm34 Non-insulin dependent diabetes mellitus QTL 34 1 4.64 4.87E-6 16.9 35457 D1Rat90 Lipid level cholesterol increased circulating triglyceride level Hypertriglyceridemia 619669 11071303 2915 Ins1 Niddm13, Niddm42, Niddm45 1 244611037 267910886 3 - by peak only 1 244822091 268121971 3 - by peak only 10008;69643;734526 BN/SsNHsd;F344/DuCrlCrlj;OLETF/Got backcross F344/NHsdxBN/SsNHsd
631837 rat Niddm35 Non-insulin dependent diabetes mellitus QTL 35 1 0.01 631287 D1Arb42a 11148 D1Mgh25 Insulin level insulin release rate was measured from individual islets at 3 and 11 mmol/1glucose decreased insulin secretion Diabetes Mellitus, Non-Insulin-Dependent 1599587;1600083;619677;619688 16951059;17130497;10580437;11723056 Niddm1 1 190677683 235677683 4 - by one flank marker only 1 190841706 235841706 4 - by one flank marker only 631294 F344.GK-(D1Arb42a-D1Rat90)/Swe
631838 rat Niddm36 Non-insulin dependent diabetes mellitus QTL 36 1 33903 D1Mit7 11148 D1Mgh25 Glucose level decreased insulin secretion Diabetes Mellitus, Non-Insulin-Dependent 619677;619688 10580437;11723056 1 235677683 240980142 1 - by flanking markers 1 235841706 241163531 1 - by flanking markers 631847 F344.GK-(D1Mit7-D1Mgh25)/Swe
631839 rat Niddm37 Non-insulin dependent diabetes mellitus QTL 37 14 3.37 33953 D14Mit1 35897 D14Rat22 2670 Gck Glucose level post-pancreatectomy non-fasting blood glucose levels were measured in male rats before and at several intervals after 70% pancreatectomy surgery increased circulating glucose level Hyperglycemia;Diabetes Mellitus, Non-Insulin-Dependent 619676 10218444 2670;2872;2874 Gck;Igfbp1;Igfbp3 14 12386493 102509397 1 - by flanking markers 14 12386414 102528608 1 - by flanking markers 61014;70509 OLETF;F344/N
631840 rat Niddm38 Non-insulin dependent diabetes mellitus QTL 38 19 3.86 36165 D19Rat13 34312 D19Mgh4 11389 D19Mgh2 Glucose level post-pancreatectomy non-fasting blood glucose levels were measured in male rats before and at several intervals after 70% pancreatectomy surgery increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 2313613;619676 19575795;10218444 2394;3199;620475 Cpe;Npy5r;Npy2r 19 10762811 24725428 1 - by flanking markers 19 10767637 24730254 1 - by flanking markers 61014;70509 OLETF;F344/N
631841 rat Niddm39 Non-insulin dependent diabetes mellitus QTL 39 3 3.36 10502 D3Mgh10 33774 D3Mit15 11355 D3Wox8 Glucose level post-pancreatectomy non-fasting blood glucose levels were measured in male rats before and at several intervals after 70% pancreatectomy surgery increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 619676 10218444 2810;2954 Hnf4a;Kcnb1 3 93894678 161985069 1 - by flanking markers 3 93791106 161891105 1 - by flanking markers 61014;70509 OLETF;F344/N
631842 rat Inf1 Infertility severity QTL 1 8 4.1 0.001 46.0 3898 Tpm1 Seminal vesicle mass the masses of testes, epididymides, and seminal vesicle were measured in 90-day male rats killed with an overdose of thiopental small seminal vesicle;reduced male fertility;decreased litter size Infertility, Male 631224 10615258 8 26358063 71358063 4 - by one flank marker only 8 26371766 71371766 4 - by one flank marker only 61117;631848 BN-Lx/Cub;SHR/OlaIpcv SHR/OlaIpcvxBN-Lx/Cub
631843 rat Niddm42 Non-insulin dependent diabetes mellitus QTL 42 1 4.1 0.016 37902 D1Rat169 42550 D1Rat459 35457 D1Rat90 Body fat amount adiposity index was calculated as the percentage of abdominal fat weight per total body weight in male rats at 30 weeks of age increased body weight;increased circulating cholesterol level Hyperglycemia;Diabetes Mellitus, Non-Insulin-Dependent 619679;619678;619669 11355573;10373320;11071303 Niddm13 1 229876870 267593558 1 - by flanking markers 1 230040894 267804643 1 - by flanking markers 61014;69643;734527 OLETF;F344/DuCrlCrlj;OLETF.F344-(D1Rat169-D1Rat459)/Got backcross OLETFxF344
631683 rat Bp116 Blood pressure QTL 116 4 1.0E-4 36143 D4Rat60 Blood pressure salt-loaded systolic measured 3 times per animal over a 5 day period by tail cuff method in male rats fed a high salt diet (8% NaCl) for a period of 5 weeks starting from 37 days of age increased systemic arterial blood pressure Hypertension 629622 12473864 2042;2096;2256;2360;2933;2949;3371;3418;3826;62017;621141 Add2;Alox5;Cald1;Clcn1;Itpr1;Kcna1;Pparg;Prss2;Tbxas1;Pebp1;Wnk1 dominant 4 127060280 172060280 3 - by peak only 4 127305122 172305122 3 - by peak only 10041;67958 SS/Jr;AS SS/JrxAS
631684 rat Bp117 Blood pressure QTL 117 1 8.3 34011 D1Mit2 Blood pressure systolic measured at 13 weeks of age by the tail-cuff method by using the average of three measurements increased systemic arterial blood pressure Hypertension 629623 12569259 1 112480604 157480604 3 - by peak only 1 112558947 157558947 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631685 rat Bp118 Blood pressure QTL 118 3 3.2 37166 D3Rat110 Blood pressure systolic measured at 13 weeks of age by the tail-cuff method by using the average of three measurements increased systemic arterial blood pressure Hypertension 629623 12569259 3 20229699 65229699 3 - by peak only 3 20126018 65126018 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631686 rat Bp119 Blood pressure QTL 119 5 3.8 11072 D5Mgh2 Blood pressure systolic measured at 13 weeks of age by the tail-cuff method by using the average of three measurements increased systemic arterial blood pressure Hypertension 629623 12569259 5 1 40017184 3 - by peak only 5 0 40017184 3 - by peak only 631286;631691 WKY/Izm;SHRSP/A3Izm SHRSP/A3IzmxWKY/Izm
631687 rat Hcas1 Hepatocarcinoma susceptibility QTL 1 7 3.9 0.001 36193 D7Rat3 34555 D7Mgh6 37802 D7Rat78 Liver tumor susceptibility nodule volume fraction neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure absent kidney Carcinoma, Hepatocellular 619598 10493520 3130 Myc dominant 7 96649133 137404381 1 - by flanking markers 7 96683363 137480819 1 - by flanking markers 60985;70509 BN;F344/N BNxF344
631688 rat Hcas2 Hepatocarcinoma susceptibility QTL 2 1 3.0 1.0E-4 43175 D1Mgh16 35166 D1Rat33 34433 D1Mgh3 Liver tumor susceptibility nodule number neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure absent kidney Carcinoma, Hepatocellular 619598 10493520 dominant 1 6253946 51253946 4 - by one flank marker only 1 6253946 116231605 1 - by flanking markers 60985;70509 BN;F344/N BNxF344
631689 rat Scl4 Serum cholesterol level QTL 4 4 1.9 0.008 3753 Spr Lipid level cholesterol serum total cholesterol was measured in an automatic analyzer using blood samples obtained by ophthalamic venous plexus puncture in 12 week old males increased circulating cholesterol level Hypercholesterolemia 619667 9633608 4 96867443 141867443 3 - by peak only 4 97111920 142111920 3 - by peak only 61107;61110 BB/OK;SHR/Mol SHR/MolxBB/OK
631690 rat Scl5 Serum cholesterol level QTL 5 1 2.1 33844 D1Mit14 Lipid level cholesterol serum total cholesterol was measured in an automatic analyzer using blood samples obtained by ophthalamic venous plexus puncture in 12 week old males increased circulating triglyceride level Hypertriglyceridemia;Hypercholesterolemia 619667 9633608 1 243502887 267910886 3 - by peak only 1 243713932 268121971 3 - by peak only 61107;61110 BB/OK;SHR/Mol SHR/MolxBB/OK
634305 rat Mamtr1 Mammary tumor resistance QTL 1 5 1.0E-4 69542 D5Uwm8 35306 D5Rat26 Mammary tumor resistance 7,12-dimethylbenzanthracene induced animals were given a single dose of DMBA in oil by gastric intubation; mammary tumors greater than 3 mm were counted at 15 weeks post DMBA administration absent spiral limbus Breast Neoplasms;Mammary Neoplasms 631852 12844486 dominant Mcs5 5 12880403 119333229 1 - by flanking markers 5 12880403 119338443 1 - by flanking markers 634359 WF.WKY-(D5Wox7-D5Uwm37)
634306 rat Bp140 Blood pressure QTL 140 3 3.3 35609 D3Rat53 38552 D3Rat80 71061 Kynu Blood pressure systolic residuals of systolic blood pressure (RSBP) were measurements of systolic blood pressure after adjusting for heart rate and body weight increased systemic arterial blood pressure Hypertension 631322 11924719 71061 Kynu 3 16185366 32056774 2 - by one flank and peak markers 3 16081734 31953146 2 - by one flank and peak markers 631603;631604 WKY/Snk;SHR/Snk intercross SHR/HosxWKY/Hos
634307 rat Bp141 Blood pressure QTL 141 6 4.0 33977 D6Mit4 Blood pressure systolic measured at the tails of conscious rats at 10 and 11 weeks of age increased systemic arterial blood pressure Hypertension 631324 10523818 6 37446751 82446751 3 - by peak only 6 37449877 82449877 3 - by peak only 634363;634364 LEW/NIcoCrlf;SHR/NIcoCrlf intercross LEW/NIcoxSHR/NIco
634308 rat Sach6 Saccharin preference QTL 6 2 4.9 31.5 38626 D2Rat171 67315 D2Arb24 36093 D2Rat26 Consumption level saccharin preference measured by the decrease of saccharin intake after a single injection of LiCl (lithium chloride) abnormal conditioned taste aversion behavior 631221 11958542 2 116874922 221284686 1 - by flanking markers 2 116819884 221271253 1 - by flanking markers 61098;61099 BXH;HXB intercross HXBxBXH
634310 rat Bp142 Blood pressure QTL 142 12 4.2 33776 D12Mit3 Blood pressure systolic measured at the tails of conscious rats at 10 and 11 weeks of age increased systemic arterial blood pressure Hypertension 631324 10523818 12 1794888 46649226 3 - by peak only 634363;634364 LEW/NIcoCrlf;SHR/NIcoCrlf
634311 rat Sach7 Saccharin preference QTL 7 4 38.5 33757 D4Mit2 2813 Hoxa2 Consumption level saccharin preference measured by the decrease of saccharin intake after a single injection of LiCl (lithium chloride) abnormal conditioned taste aversion behavior 631221 11958542 4 55369931 80464927 1 - by flanking markers 4 55620765 80742437 1 - by flanking markers 61098;61099 BXH;HXB intercross HXBxBXH
634312 rat Bp143 Blood pressure QTL 143 1 3.0 2.0E-4 12.0 38326 D1Rat129 41036 D1Rat298 37184 D1Rat188 Blood pressure systolic measured by radiotelemetry after 8 weeks of high salt (8% NaCl) diet increased systemic arterial blood pressure Hypertension 631325 11984003 1 198853034 225625256 1 - by flanking markers 1 199003017 225789279 1 - by flanking markers 634365;634366 SS/Hsd;SR/Hsd intercross SS/HsdxSR/Hsd
634313 rat Niddm43 Non-insulin dependent diabetes mellitus QTL 43 1 34244 D1Mgh10 35457 D1Rat90 Glucose level impaired glucose tolerance;decreased circulating insulin level Glucose Intolerance 619688;619677 11723056;10580437 Niddm44;Niddm1 1 204280278 267111153 1 - by flanking markers 1 204433664 267322172 1 - by flanking markers 631846 F344.GK-(D1Mgh10-D1Rat90)/Swe
634314 rat Niddm44 Non-insulin dependent diabetes mellitus QTL 44 1 34244 D1Mgh10 35891 D1Rat19 Glucose level decreased circulating insulin level;impaired glucose tolerance Glucose Intolerance 619688;619677 11723056;10580437 Niddm1;Niddm43 1 43872827 204280278 1 - by flanking markers 1 43875772 204433664 1 - by flanking markers 634370 F344.GK-(D1Mgh10-D1Rat119)/Swe
634315 rat Niddm45 Non-insulin dependent diabetes mellitus QTL 45 1 7.16 34399 D1Mgh9 33959 D1Mit3 Glucose level postprandial oral glucose tolerance tests given to male rats to measure fasting and postprandial (30 min after application) plasma glucose levels increased circulating glucose level;abnormal percent body fat Hyperglycemia;Diabetes Mellitus, Non-Insulin-Dependent 619678 10373320 1 146971983 176854992 1 - by flanking markers 1 147050389 176994239 1 - by flanking markers 60985;61014 BN;OLETF backcross OLETFxBN
634317 rat Niddm46 Non-insulin dependent diabetes mellitus QTL 46 3 3.58 34336 D3Mgh7 36456 D3Rat41 Body fat amount adiposity index was calculated as the percentage of abdominal fat weight per total body weight in male rats at 30 weeks of age abnormal lateral ganglionic eminence morphology Obesity 2313613;619678 19575795;10373320 3 36556706 50635971 1 - by flanking markers 3 36453079 50532448 1 - by flanking markers 60985;61014 BN;OLETF intercross OLETFxBN
634318 rat Niddm47 Non-insulin dependent diabetes mellitus QTL 47 6 3.55 33977 D6Mit4 33828 D6Mit9 Body fat amount abdominal fat abdominal fat weight and total body weight were measured in 30 week old male rats; adiposity index is calculated as percentage of abdominal fat weight per total body weight decreased circulating glucose level;decreased body weight;abnormal caudal ganglionic eminence morphology Obesity 619678 10373320 6 34039461 59946628 1 - by flanking markers 6 34042414 59949755 1 - by flanking markers 60985;61014 BN;OLETF intercross OLETFxBN
634319 rat Niddm48 Non-insulin dependent diabetes mellitus QTL 48 7 5.44 60737 D7Mit29 36691 D7Rat27 36715 D7Rat30 Body fat amount adiposity index adiposity index was calculated as the percentage of abdominal fat weight per total body weight in male rats at 30 weeks of age impaired glucose tolerance;abnormal caudal ganglionic eminence morphology Obesity;Diabetes Mellitus, Non-Insulin-Dependent 619678 10373320 7 28674040 32004684 2 - by one flank and peak markers 7 25960193 32024955 1 - by flanking markers 60985;61014 BN;OLETF intercross OLETFxBN
634320 rat Niddm49 Non-insulin dependent diabetes mellitus QTL 49 10 4.41 11169 D10Mgh21 33941 D10Mit11 Glucose level postprandial oral glucose tolerance tests given to male rats to measure fasting and postprandial (30 min after application) plasma glucose levels decreased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent 619678 10373320 10 92782172 101848683 1 - by flanking markers 10 92796542 101863126 1 - by flanking markers 60985;61014 BN;OLETF intercross OLETFxBN
634321 rat Hc1 Hypercalciuria QTL 1 1 2.91 7.0 39006 D1Rat193 38078 D1Rat142 37902 D1Rat169 Renal function calcium excretion animals at 8 wk of age were placed in individual metabolic cages for measurement of urinary calcium excretion on a normal-calcium diet hypercalciuria Kidney Calculi 631855 12819244 1 183163129 248833756 1 - by flanking markers 1 183304795 249092593 1 - by flanking markers 61103;634372 WKY;GHS intercross SD/GHSxWKY
634322 rat Bw12 Body weight QTL 12 7 8.6 37808 D7Rat86 38402 D7Rat102 38402 D7Rat102 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased body weight Obesity 619682 11414764 7 88132195 115934193 1 - by flanking markers 7 88152926 115968423 1 - by flanking markers 634367;634369 BN/CrlCrlj;WBN/KobSlc intercross BN/CrjxWBN/KobSlc
634323 rat Hc2 Hypercalciuria QTL 2 4 2.15 39704 D4Rat222 Renal function calcium excretion animals at 8 wk of age were placed in individual metabolic cages for measurement of urinary calcium excretion on a normal-calcium diet hypercalciuria Kidney Calculi 631855 12819244 4 1 41544239 3 - by peak only 4 0 41544336 3 - by peak only 61103;634372 WKY;GHS intercross SD/GHSxWKY
634325 rat Bw13 Body weight QTL 13 X 12.2 35030 DXRat2 36111 DXRat8 Body weight body weight was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks increased circulating insulin level;increased body weight;pancreas inflammation Hyperinsulinism;Pancreatitis 619682 11414764 X 1 41387080 4 - by one flank marker only X 0 41440508 4 - by one flank marker only 634367;634369 BN/CrlCrlj;WBN/KobSlc intercross BN/CrjxWBN/KobSlc
634326 rat Hc3 Hypercalciuria QTL 3 7 2.1 40164 D7Rat164 Renal function calcium excretion animals at 8 wk of age were placed in individual metabolic cages for measurement of urinary calcium excretion on a normal-calcium diet hypercalciuria Kidney Calculi 631855 12819244 7 47007003 92007003 3 - by peak only 7 47027733 92027733 3 - by peak only 61103;634372 WKY;GHS intercross SD/GHSxWKY
634327 rat Hc4 Hypercalciuria QTL 4 10 2.4 35769 D10Rat47 Renal function calcium excretion animals at 8 wk of age were placed in individual metabolic cages for measurement of urinary calcium excretion on a normal-calcium diet hypercalciuria Kidney Calculi 631855 12819244 10 1 38576664 3 - by peak only 10 0 38577713 3 - by peak only 61103;634372 WKY;GHS intercross SD/GHSxWKY
634328 rat Hc5 Hypercalciuria QTL 5 14 2.3 11086 D14Mgh1 Renal function calcium excretion animals at 8 wk of age were placed in individual metabolic cages for measurement of urinary calcium excretion on a normal-calcium diet hypercalciuria Kidney Calculi 631855 12819244 61103;634372 WKY;GHS
634329 rat Pia15 Pristane induced arthritis QTL 15 10 3.1 36319 D10Rat26 36522 D10Rat44 34318 D10Mgh10 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;631850 18606636;16804090;18540828;12817024 dominant 10 24731630 47777990 2 - by one flank and peak markers 10 24732679 47779039 2 - by one flank and peak markers 634373;634374 DA/ZtmRhd;E3/ZtmRhd backcross DA/RhdxE3/Rhd
634330 rat Pia16 Pristane induced arthritis QTL 16 6 3.9 34072 D6Mgh7 34108 D6Mgh10 35102 D6Rat16 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;631850 18606636;16804090;18540828;12817024 dominant 6 47039212 108621490 1 - by flanking markers 6 47042339 108624946 1 - by flanking markers 634373;634374 DA/ZtmRhd;E3/ZtmRhd backcross DA/RhdxE3/Rhd
634331 rat Pia17 Pristane induced arthritis QTL 17 7 4.7 11165 D7Mit9 37144 D7Rat74 33670 D7Mit2 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;631850 18606636;16804090;18540828;12817024 dominant 7 78497123 137838800 1 - by flanking markers 7 78517853 137915237 1 - by flanking markers 634373;634374 DA/ZtmRhd;E3/ZtmRhd backcross DA/RhdxE3/Rhd
634332 rat Pia18 Pristane induced arthritis QTL 18 8 4.0 35905 D8Rat21 35248 D8Rat26 34068 D8Mgh11 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint swelling Arthritis, Rheumatoid 2300074;1582387;2307198;631850 18606636;16804090;18540828;12817024 dominant 8 79347688 87122814 1 - by flanking markers 8 79366742 87142270 1 - by flanking markers 634373;634374 DA/ZtmRhd;E3/ZtmRhd backcross DA/RhdxE3/Rhd
634333 rat Pia19 Pristane induced arthritis QTL 19 18 3.4 35282 D18Rat5 33715 D18Mit6 33715 D18Mit6 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;631850 18540828;18606636;16804090;12817024 dominant 18 77452390 82920522 1 - by flanking markers 18 77525664 82993972 1 - by flanking markers 634373;634374 DA/ZtmRhd;E3/ZtmRhd backcross DA/RhdxE3/Rhd
634334 rat Xhs3 X-ray hypersensitivity QTL 3 4 10.0 42306 D4Rat266 35262 D4Rat79 36043 D4Rat49 X-ray sensitivity animals wrere X-irradiated at 5 weeks of age at 0.2 Gy/min and somatic effects (moribundity with diarrhea) was examined twice a day within 7 days increased cellular sensitivity to X-ray irradiation 631318 11381618 recessive Xhs1 4 84355208 131969855 1 - by flanking markers 4 84598387 132214696 1 - by flanking markers 634376;634377 LEA/Ncu;BN/Sea intercross LEA/NcuxBN/Sea
634335 rat Anxrr16 Anxiety related response QTL 16 4 7.22 50.4 34338 D4Mgh11 35286 D4Rat37 34106 D4Mgh6 Anxiety response determined by number of outer squares crossed, number of inner squares crossed and total number of fecal boli increased anxiety-related response Anxiety Disorders 1598975;1598390;631324 17052845;16923148;10523818 3811 Tacr1 dominant 4 93498821 171204377 1 - by flanking markers 4 93743302 171449313 1 - by flanking markers 634363;634364 LEW/NIcoCrlf;SHR/NIcoCrlf intercross LEW/NIcoxSHR/NIco
634336 rat Anxrr17 Anxiety related response QTL 17 7 3.66 39648 D7Rat127 34039 D3Mit11 34164 D7Mgh11 Anxiety response determined by number of outer squares crossed, number of inner squares crossed and total number of fecal boli decreased anxiety-related response Anxiety Disorders 1598975;1598390;631324 17052845;16923148;10523818 additive 7 1786555 121975577 1 - by flanking markers 634363;634364 LEW/NIcoCrlf;SHR/NIcoCrlf intercross LEW/NIcoxSHR/NIco
634338 rat Hcar4 Hepatocarcinoma resistance QTL 4 1 4.6 34021 D1Mit28 43424 D1Wox10 34244 D1Mgh10 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced number of enzyme altered foci (EAF) expressing glutathione S-transferase placental form per cm2 liver section was measured on histological analysis of livers of male rats who were fed 3-methyl-3-dimethylaminoazobenzene (3 Me-DAB), percent liver area occupied by foci, and average foci size were also correlated impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 625382;619609 11756240;10850431 2315;2758;2775;2827;2829;2870;2916 Cd81;Gstp1;H19;Hras;Pla2g16;Igf2;Ins2 recessive 1 198396582 220639653 1 - by flanking markers 1 198546574 220803676 1 - by flanking markers 70509;625659 F344/N;DRH/Seac intercross DRHxF344
634339 rat Niddm50 Non-insulin dependent diabetes mellitus QTL 50 11 3.32 34725 D11Mgh3 34150 D11Mgh5 Glucose level fasting oral glucose tolerance tests given to male rats to measure fasting and postprandial (30 min after application) plasma glucose levels abnormal percent body fat;increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 61072;619678 9585427;10373320 11 43157054 68234781 1 - by flanking markers 11 43214643 68292371 1 - by flanking markers 60985;61014 BN;OLETF intercross OLETFxBN
634340 rat Hcar5 Hepatocarcinoma resistance QTL 5 1 8.1 43424 D1Wox10 41392 D1Rat302 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced number of enzyme altered foci (EAF) expressing glutathione S-transferase placental form per cm2 liver section, percent liver area occupied by foci, and GST placental form mRNA levels measured on histological and mRNA analysis of livers of male rats who were fed 3-methyl-3-dimethylaminoazobenzene (3 Me-DAB) impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 625382;619609 11756240;10850431 2456;2469 Cyp17a1;Cyp2c11 recessive 1 220639539 232579992 1 - by flanking markers 1 220803562 232744015 1 - by flanking markers 70509;625659 F344/N;DRH/Seac intercross DRHxF344
634341 rat Niddm51 Non-insulin dependent diabetes mellitus QTL 51 11 3.5 34150 D11Mgh5 33899 D11Mit4 Body fat amount abdominal fat abdominal fat weight and total body weight were measured in male rats sacrificed at 30 weeks of age; adiposity index was calculated as the percentage of abdominal fat weight per total body weight abnormal lateral ganglionic eminence morphology;increased body weight Obesity 619678 10373320 11 22214205 43156819 1 - by flanking markers 11 22214205 43214409 1 - by flanking markers 60985;61014 BN;OLETF backcross OLETFxBN
634342 rat Cia24 Collagen induced arthritis QTL 24 4 4.5 7.6 33995 D4Mit19 10752 D4Wox12 11163 D4Arb2 Joint/bone inflammation type II collagen induced type II collagen was pepsin-solubilized from porcine (PII) and rat (RII) sternal cartilage samples; arthritis severity was determined by total score for each extremity; the 3 joints (interphalangeal, metatarsophalangeal, metacarpophalangeal) of each of the lateral 4 digits were scored 0 or 1 (0 5 no arthritis and 1 5 arthritis), and the wrist, mid-forepaw, ankle, and mid-foot were scored 04 (0 5 normal, 1 5 minimal swelling, 2 5 medium swelling, 3 5 severe swelling, and 4 5 ankylosis) joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;61066 18540828;18606636;16804090;10857786 2306;61318;61319;621237 Cd4;Cd69;Tnfrsf7;Tnfrsf1a additive 4 149304432 179854843 1 - by flanking markers 4 149549274 180099967 1 - by flanking markers 61114;61115 DA/Bkl;BN/SsN intercross DA/BklxBN/SsN
634343 rat Hcar6 Hepatocarcinoma resistance QTL 6 1 10674 D1Mgh12 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced percent liver area occupied by enzyme altered foci expressing glutathione S-transferase placental form, average foci size, and GST placental form mRNA levels measured on histological and mRNA analysis of livers of male rats who were fed 3-methyl-3-dimethylaminoazobenzene (3 Me-DAB) impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 619609 10850431 recessive 1 224822211 267910886 3 - by peak only 1 224936686 268121971 3 - by peak only 70509;625659 F344/N;DRH/Seac intercross DRHxF344
634344 rat Hcar7 Hepatocarcinoma resistance QTL 7 4 7.8 35811 D4Rat23 35286 D4Rat37 35286 D4Rat37 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced number of enzyme altered foci (EAF) expressing glutathione S-transferase placental form per cm2 liver section, percent liver area occupied by foci, and average foci size, and GST placental form mRNA levels were measured on histological and mRNA analysis of livers of male rats who were fed 3-methyl-3-dimethylaminoazobenzene (3 Me-DAB) impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 625382;619609 11756240;10850431 2688 Ghrhr semidominant 4 58550170 93498821 1 - by flanking markers 4 58826300 93743302 1 - by flanking markers 70509;625659 F344/N;DRH/Seac intercross DRHxF344
634346 rat Insul4 Insulin level QTL 4 X 20.0 12.0 39724 DXRat103 60694 DxGot62 Insulin level following a 9hr fast males underwent an oral glucose tolerance test; serum insulin was measured at 30 min. pancreas inflammation;increased heart weight;increased circulating insulin level Pancreatitis;Hyperinsulinism 619682 11414764 additive X 134157190 160699376 4 - by one flank marker only X 134230663 160775580 4 - by one flank marker only 634367;634369 BN/CrlCrlj;WBN/KobSlc intercross BN/CrjxWBN/KobSlc
634347 rat Hcar8 Hepatocarcinoma resistance QTL 8 4 36508 D4Rat48 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced number of enzyme altered foci (EAF) expressing glutathione S-transferase placental form per cm2 liver section, percent liver area occupied by foci, and average foci size were measured on histological analysis of livers of male rats who were fed 3-methyl-3-dimethylaminoazobenzene (3 Me-DAB) impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 625382;619609 11756240;10850431 3849 Tgfa semidominant 70509;625659 F344/N;DRH/Seac intercross DRHxF344
634348 rat Bp138 Blood pressure QTL 138 1 37428 D1Rat200 2254 Calca 34011 D1Mit2 Blood pressure increased systemic arterial blood pressure Hypertension 631321 12358148 2156;2254;3214;621323 Arrb1;Calca;Ntrk3;Phox2a 1 126938969 172691061 1 - by flanking markers 1 127017358 172827127 1 - by flanking markers 631286;631599 WKY/Izm;SHRSP/Izm intercross SHRSP/IzmxWKY/Izm
634349 rat Bp139 Blood pressure QTL 139 5 0.001 10454 D5Wox12 43937 D5Wox20 Blood pressure systolic arterial blood pressures were measured continuously in conscious male rats between 80 and 100 days of age; at the end of study, body weight, heart and kidney weights were obtained from sacrificed animals increased systemic arterial blood pressure Hypertension 631851 12790759 Bp7 5 135877124 173096209 4 - by one flank marker only 5 135882350 173106704 4 - by one flank marker only 634382 SHR.BN-(D5Wox12-D5Wox20)/Ipcv
634350 rat Apr4 Acute phase response QTL 4 12 6.0 35889 D12Rat10 Alpha1 acid glycoprotein level pristane induced abnormal acute phase protein physiology Arthritis, Rheumatoid 629561 11817600 recessive 12 2248421 46782294 3 - by peak only 12 2111638 46649226 3 - by peak only 60997;61013 DA;E3 intercross E3xDA
634351 rat Apr5 Acute phase response QTL 5 12 6.7 11449 D12Wox14 IL-6 level pristane induced abnormal interleukin-6 physiology Arthritis, Rheumatoid 629561 11817600 recessive 60997;61013 DA;E3 intercross E3xDA
634352 rat Apr6 Acute phase response QTL 6 14 3.7 10622 D14Mgh3 IL-6 level pristane induced abnormal interleukin-6 physiology Arthritis, Rheumatoid 629561 11817600 recessive Pia6 14 1 42665455 3 - by peak only 14 0 42665455 3 - by peak only 60997;61013 DA;E3 intercross E3xDA
634353 rat Rends2 Renal damage susceptibility QTL 2 1 0.05 36303 D1Rat6 37962 D1Rat201 38568 D1Rat238 Renal histology renal lesion severity transverse 5-mm sections of each individual kidney, including the apex of the pyramid, the corticomedullary junction, and the cortex, were examined; lesions were graded according to the degree of vascular and parenchymal damage, following classification as absence of renal lesions grade 0, presence of mild lesions as grade 0.5, presence of moderate lesions as grade 1, and presence of severe lesions as grades 2 and 3 abnormal kidney vasculature morphology Kidney Failure, Chronic 631854 12874092 Rf2 61000;61010 SHR;SHRSP intercross SHRSPxSHR
634354 rat Rends3 Renal damage susceptibility QTL 3 10 0.05 35563 D10Rat21 34939 D10Rat55 2875 Igfbp4 Renal histology renal lesion severity transverse 5-mm sections of each individual kidney, including the apex of the pyramid, the corticomedullary junction, and the cortex, were examined; lesions were graded according to the degree of vascular and parenchymal damage, following classification as absence of renal lesions grade 0, presence of mild lesions as grade 0.5, presence of moderate lesions as grade 1, and presence of severe lesions as grades 2 and 3 abnormal kidney vasculature morphology Kidney Failure, Chronic 631854 12874092 10 83527877 89167279 1 - by flanking markers 10 83542248 89181649 1 - by flanking markers 61000;61010 SHR;SHRSP SHRSPxSHR
634355 rat Rends4 Renal damage susceptibility QTL 4 16 0.05 33848 D16Mit2 Renal histology renal lesion severity transverse 5-mm sections of each individual kidney, including the apex of the pyramid, the corticomedullary junction, and the cortex, were examined; lesions were graded according to the degree of vascular and parenchymal damage, following classification as absence of renal lesions grade 0, presence of mild lesions as grade 0.5, presence of moderate lesions as grade 1, and presence of severe lesions as grades 2 and 3 abnormal kidney vasculature morphology Kidney Failure, Chronic 631854 12874092 16 1 26804456 3 - by peak only 16 0 26804454 3 - by peak only 61000;61010 SHR;SHRSP intercross SHRSPxSHR
724538 rat Kidm1 Kidney mass QTL 1 1 3.2 62481 D1Uia5 36703 D1Rat86 36703 D1Rat86 Kidney mass calculated by adjusting kidney weight for differences in body weight by regression analysis decreased circulating free fatty acid level Kidney Diseases 634617 12707388 1 219804771 259173490 1 - by flanking markers 1 219968794 259439404 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724539 rat Cm19 Cardiac mass QTL 19 8 2.6 41310 D8Rat130 35435 D8Rat3 37892 D8Rat90 Cardiac mass calculated by adjusting heart weight for differences in body weight by regression analysis increased heart weight Heart Diseases 634617 12707388 8 98986085 126316942 1 - by flanking markers 8 99005540 126336679 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724540 rat Uae8 Urinary albumin excretion QTL 8 8 5.0 33559 D8Mit5 41310 D8Rat130 40746 D8Rat162 Renal function urine abumin level determined by SDS-PAGE proteinuria;albuminuria Albuminuria;Proteinuria 634617 12707388 8 32203394 98986263 1 - by flanking markers 8 32212161 99005718 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724541 rat Niddm53 Non-insulin dependent diabetes mellitus QTL 53 14 0.001 36536 D14Rat1 37030 D14Rat3 Glucose level determined using the oral glucose tolerance test after overnight starvation impaired glucose tolerance Glucose Intolerance 619670 11381614 Niddm20 14 4895894 10340377 1 - by flanking markers 14 4895895 10340272 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got intercross OLETF/OtkxF344/Crj
724542 rat Kidm2 Kidney mass QTL 2 18 2.6 38862 D18Rat69 Kidney mass calculated by adjusting kidney weight for differences in body weight by regression analysis decreased circulating free fatty acid level Kidney Diseases 634617 12707388 18 62739615 87265094 3 - by peak only 18 62813065 87338544 3 - by peak only 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724543 rat Cm20 Cardiac mass QTL 20 9 3.9 35871 D9Rat36 35819 D9Rat26 37416 D9Rat70 Cardiac mass calculated by adjusting heart weight for differences in body weight by regression analysis increased heart weight Heart Diseases 634617 12707388 9 12625041 37313370 1 - by flanking markers 9 12622363 37314694 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724544 rat Uae9 Urinary albumin excretion QTL 9 9 4.5 37416 D9Rat70 66431 D9Mco6 61287 D9Uia6 Renal function urine albumin level determined by SDS-PAGE albuminuria Albuminuria 634617 12707388 9 21667066 105580061 1 - by flanking markers 9 21668480 105789541 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724545 rat Niddm54 Non-insulin dependent diabetes mellitus QTL 54 15 0.02 35362 D15Rat19 35230 D15Rat22 Glucose level determined using the oral glucose tolerance test after overnight starvation impaired glucose tolerance Glucose Intolerance 619670 11381614 15 56346569 80370658 1 - by flanking markers 15 56362349 80386438 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got intercross OLETF/OtkxF344/Crj
724546 rat Kidm3 Kidney mass QTL 3 19 3.1 39018 D19Rat29 66451 D19Uia1 66451 D19Uia1 Kidney mass calculated by adjusting kidney weight for differences in body weight by regression analysis decreased circulating free fatty acid level Kidney Diseases 634617 12707388 19 31224173 59218465 4 - by one flank marker only 19 31228888 59223525 4 - by one flank marker only 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724547 rat Cm21 Cardiac mass QTL 21 9 2.7 61287 D9Uia6 66431 D9Mco6 38270 D9Rat97 Cardiac mass calculated by adjusting heart weight for differences in body weight by regression analysis increased heart weight Heart Diseases 634617 12707388 9 77170797 105580061 1 - by flanking markers 9 77354082 105789541 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724548 rat Niddm55 Non-insulin dependent diabetes mellitus QTL 55 15 0.02 35230 D15Rat22 36663 D15Rat21 Glucose level determined using the oral glucose tolerance test after overnight starvation impaired glucose tolerance Glucose Intolerance 619670 11381614 15 74779895 80370512 1 - by flanking markers 15 74795675 80386293 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got intercross OLETF/OtkxF344/Crj
724549 rat Niddm56 Non-insulin dependent diabetes mellitus QTL 56 17 0.03 33882 D17Mit2 34369 D17Mgh4 Glucose level determined using the oral glucose tolerance test after overnight starvation impaired glucose tolerance Glucose Intolerance 619670 11381614 Niddm32 17 38353858 83353858 4 - by one flank marker only 17 38356700 83356700 4 - by one flank marker only 69643;734526 F344/DuCrlCrlj;OLETF/Got intercross OLETF/OtkxF344/Crj
724550 rat Thym3 Thymus enlargement QTL 3 1 7.82 0.001 33571 D1Mit6 10952 D1Wox21 38210 D1Rat197 Gland mass thymus the ratio of thymus weight to body weight increases for 6 months then decreases slowly increasing again after 9 months enlarged thymus Thymus Hyperplasia 70859 10792781 Ten1 1 141471946 186471946 4 - by one flank marker only 1 141621827 186621827 4 - by one flank marker only 61118;724571 BUF/Mna;MITE/Mna backcross BUF/MnaxMITE/Mna
724551 rat Glom1 Glomerulus QTL 1 X 2.8 4.0E-4 39966 DXRat96 Renal histology number of superficial glomeruli (SfG) number of superficial glomeruli present in the renal cortex corticis zone but without direct surface contact counted in three mid-coronal sections for each animal increased surface glomeruli Albuminuria;Proteinuria 634618 12397040 X 99569771 144569771 3 - by peak only X 99643204 144643204 3 - by peak only 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724552 rat Glom2 Glomerulus QTL 2 1 3.3 1.0E-4 37506 D1Rat151 Renal histology number of surface glomeruli (SG) measured by counting the number of surface glomeruli per section with direct contact to the surface increased surface glomeruli Albuminuria;Proteinuria 634618 12397040 1 229199390 268121971 3 - by peak only 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724553 rat Glom3 Glomerulus QTL 3 13 2.9 4.0E-4 39348 D13Rat62 Renal histology number of surface glomeruli (SG) measured by counting the number of surface glomeruli per section with direct contact to the surface increased surface glomeruli Albuminuria;Proteinuria 634618 12397040 13 38179982 83179982 3 - by peak only 13 38194062 83194062 3 - by peak only 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724554 rat Iddm17 Insulin dependent diabetes mellitus QTL 17 11 0.001 10847 D11Mit8 34130 D11Mgh6 10911 D11Wox3 Insulin level pancreas inflammation Glucose Intolerance 634732;70861 9329965;8702404 11 19445919 87759784 2 - by one flank and peak markers 11 19445919 87800381 2 - by one flank and peak markers 68074;724576 LETO;KDP/Tky backcross LETOxPKDP
724555 rat Bp150 Blood pressure QTL 150 10 1.0E-4 36203 D10Rat27 37460 D10Rat93 Blood pressure increased systemic arterial blood pressure Hypertension 704345 12939233 10 77091834 81887390 1 - by flanking markers 10 77106262 81901760 1 - by flanking markers 724577 SS.LEW-(D10Rat27-Igfbp4)/Ayd
724556 rat Pur2 Proteinuria QTL 2 10 5.5 62429 D10Uia2 34896 D10Rat17 66468 D10Mco57 Renal function level of protein excreted in urine was was determined colorimetrically using pyrogallol red/molybdate complex proteinuria Proteinuria 634617 12707388 10 22915259 95066632 1 - by flanking markers 10 22916308 95080863 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724557 rat Plsm1 Polydactyly-luxate syndrome (PLS) morphotypes QTL 1 4 3.0E-4 2901 Il6 Limb morphology front feet phalanges number bone morphometrics of tibia and fibula from hind and front limbs measured at the age of 4 months polydactyly Polydactyly 632346 8997636 2901 Il6 4 1 22959087 3 - by peak only 4 0 22959087 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-lx/Cub
724558 rat Plsm2 Polydactyly-luxate syndrome (PLS) morphotypes QTL 2 4 3.0E-4 2004 A2m Limb morphology hind feet phalanges number bone morphometrics of tibia and fibula from hind and front limbs measured at the age of 4 months polydactyly Polydactyly 632346 8997636 2004 A2m 4 135628567 180628567 3 - by peak only 4 135873491 180873491 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-lx/Cub
724559 rat Pancm1 Pancreatic morphology QTL 1 1 7.1 8.0 43424 D1Wox10 3750 Spn 11060 D1Wox23 Pancreatic morphology pancreatic sections were immunohistochemically stained and graded by two observers according to criteria; pancreatic histology was quantitatively analyzed for the number of islets, the area of the islets and average islet area, and the area of the entire pancreatic section abnormal pancreatic islet morphology Diabetes Mellitus, Non-Insulin-Dependent 61083 9169130 3750 Spn 1 186391887 220639539 1 - by flanking markers 1 186541733 220803562 1 - by flanking markers 61103;61112 WKY;13M Intercross 13MxWKY
724560 rat Plsm3 Polydactyly-luxate syndrome (PLS) morphotypes QTL 3 7 3.0E-4 33721 D7Mit17 Limb morphology tibia length bone morphometrics of tibia and fibula from hind and front limbs measured at the age of 4 months short tibia Limb Deformities, Congenital 632346 8997636 7 1 35575619 3 - by peak only 7 0 35575620 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-lx/Cub
724561 rat Plsm4 Polydactyly-luxate syndrome (PLS) morphotypes QTL 4 11 3.0E-4 3761 Sst Limb morphology front feet phalanges number bone morphometrics of tibia and fibula from hind and front limbs measured at the age of 4 months polydactyly Polydactyly 632346 8997636 11 56625623 87759784 3 - by peak only 11 56683212 87800381 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-lx/Cub
724562 rat Rends1 Renal damage susceptibility QTL 1 1 0.05 33959 D1Mit3 2870 Igf2 Renal histology renal lesion severity measured 33 days after deoxycorticosterone acetate (DOCA)-salt administration; abnormal glomeruli were defined by: (a) acute hypertensive injury (necrosis, thrombosis, microembolisms, and capillary wall disruption), (b) segmental glomerular sclerosis (collapsed capillary loops with mesangial matrix expansion), and (c) ischemic injury (globally shrunk glomeruli with collapsed capillary loops); the total number of acute vascular hypertensive injury (fibrinoid necrosis, myointimal proliferation, fragmentation of internal elastic lamellae, and aneurysmal dilatation) were counted in each section abnormal renal glomerulus morphology;proteinuria;abnormal kidney vasculature morphology Kidney Failure, Chronic;Proteinuria 632218 10454439 Rf2 1 146971846 202915231 1 - by flanking markers 1 147050253 203103297 1 - by flanking markers 628908;724578 SHR.BN-(D1Mit3-Igf2)/Ipcv;SHR.BN-(D1Mit2-Igf2)
724563 rat Uae10 Urinary albumin excretion QTL 10 11 6.0 36906 D11Rat17 37512 D11Rat50 39698 D11Rat67 Renal function urine albumin level determined by SDS-PAGE proteinuria;albuminuria Albuminuria;Proteinuria 634617 12707388 11 28213024 84841212 1 - by flanking markers 11 28213025 84881809 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724564 rat Uae11 Urinary albumin excretion QTL 11 13 5.7 11231 D13Wox5 37240 D13Rat63 38990 D13Rat58 Renal function urine albumin level determined by SDS-PAGE albuminuria Albuminuria 634617 12707388 13 46269934 80482429 1 - by flanking markers 13 46283977 80496617 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724565 rat Tcas5 Tongue tumor susceptibility QTL 5 19 10.04 33581 D19Mit1 10418 D19Mit6 11471 D19Mit9 Tongue tumor susceptibility measured by the number of the tongue carcinomas (TCs) >3 mm ; animals given drinking water containing 0.001% 4NQO at six weeks of age and were killed when they became moribund or on the 180th day abnormal Deiters cell morphology Tongue Neoplasms 634723 11429048 2503;2944 Nqo1;Junb semidominant Stc1 19 4034890 49034890 3 - by peak only 19 11461668 41617762 2 - by one flank and peak markers 60997;61007 DA;WF intercross DAxWF
724566 rat Uae12 Urinary albumin excretion QTL 12 19 5.0 39128 D19Rat34 66451 D19Uia1 39018 D19Rat29 Renal function urine albumin level determined by SDS-PAGE albuminuria Albuminuria 634617 12707388 19 2264957 59218465 2 - by one flank and peak markers 19 2265038 59223525 2 - by one flank and peak markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724567 rat Tcas6 Tongue tumor susceptibility QTL 6 1 6.85 34037 D1Mit1 33959 D1Mit3 39428 D1Rat320 Tongue tumor susceptibility measured by the number of the tongue carcinomas (TCs) >3 mm ; animals given drinking water containing 0.001% 4NQO at six weeks of age and were killed when they became moribund or on the 180th day abnormal Deiters cell morphology Tongue Neoplasms 634723 11429048 2466 Cyp2b1 semidominant Rtc1 1 92101613 146971983 2 - by one flank and peak markers 1 56717951 147050389 1 - by flanking markers 60997;61007 DA;WF intercross DAxWF
724568 rat Uae13 Urinary albumin excretion QTL 13 2 4.4 35857 D2Rat36 34884 D2Rat57 39374 D2Rat126 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 634633;634617 12799471;12707388 2 161170272 218568266 2 - by one flank and peak markers 2 161126028 218531328 2 - by one flank and peak markers 10041;631696 SS/Jr;SHR/FubRkb intercross SS/JrxSHR/Rkb
734767 rat Niddm57 Non-insulin dependent diabetes mellitus QTL 57 1 37902 D1Rat169 42550 D1Rat459 Body weight body weight (BW) was measured at 16, 20, 24, 28 and 29 weeks; abdominal fat (FW) from mesenteric, epididymal and retroperitoneal tissues, plasma lipids (TC, TG, NEFA) and plasma insulin (INS) were measured on fasting animals at 29 weeks; oral glucose tolerance (OGTT) was measured on fasting animasl at 28 weeks increased circulating cholesterol level;increased body weight Hypercholesterolemia;Hypertriglyceridemia;Obesity 619679 11355573 Niddm42;Niddm59 1 229876870 267593558 1 - by flanking markers 1 230040894 267804643 1 - by flanking markers 734527 OLETF.F344-(D1Rat169-D1Rat459)/Got
734768 rat Niddm59 Non-insulin dependent diabetes mellitus QTL 59 1 40126 D1Rat306 42553 D1Rat461 Body weight body weight (BW) was measured at 16, 20, 24, 28 and 29 weeks; abdominal fat (FW) from mesenteric, epididymal and retroperitoneal tissues, plasma lipids (TC, TG, NEFA) and plasma insulin (INS) were measured on fasting animals at 29 weeks; oral glucose tolerance (OGTT) was measured on fasting animasl at 28 weeks abnormal caudal ganglionic eminence morphology;decreased triglyceride level;decreased circulating cholesterol level;decreased body weight Diabetes Mellitus, Non-Insulin-Dependent;Obesity 734465 12190994 Niddm42;Niddm57 1 248583506 266234810 1 - by flanking markers 1 248843278 266445855 1 - by flanking markers 734531 OLETF.F344-(D1Rat306-D1Rat461)/Got
734769 rat Niddm58 Non-insulin dependent diabetes mellitus QTL 58 1 36960 D1Rat76 42550 D1Rat459 Body weight body weight (BW) was measured at 16, 20, 24, 28 and 29 weeks; plasma insulin (INS) were measured on fasting animals at 29 weeks; plasma triglycerides were measured at 8, 10, 18, and 29 weeks decreased body weight;abnormal caudal ganglionic eminence morphology;improved glucose tolerance;decreased circulating insulin level;decreased circulating triglyceride level Diabetes Mellitus, Non-Insulin-Dependent;Insulin Resistance;Obesity 619683 11153534 additive Niddm13 1 230411091 267593558 1 - by flanking markers 1 230575134 267804643 1 - by flanking markers 734528 OLETF.BN-(D1Rat76-D1Rat459)/Got
731164 rat Uae25 Urinary albumin excretion QTL 25 9 3.5 1.0E-4 36984 D9Rat29 36027 D9Rat3 36556 D9Rat10 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 730279 14638907 9 22066101 99799902 1 - by flanking markers 9 22067655 100009382 1 - by flanking markers 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731165 rat Uae21 Urinary albumin excretion QTL 21 4 2.4 1.0E-4 38458 D4Rat95 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 730279 14638907 4 108641841 153641841 3 - by peak only 4 108886682 153886682 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731166 rat Mamtr2 Mammary tumor resistance QTL 2 2 1.0E-4 33822 D2Mit29 67798 D2Uwm14 Mammary tumor resistance treated with 7,12-dimethylbenz(a)anthracene (DMBA) for 15 weeks; total number of mammary carcinomas > 3 x 3 mm in diameter enumerated absent spiral limbus Breast Neoplasms 724790 14522903 semidominant Mcs1 2 5601528 10539334 1 - by flanking markers 2 5627976 10463527 1 - by flanking markers 728387 WF.COP-(D2Mit29-D2Uwm13)/Uwm intercross WFxCOP
731167 rat Glom4 Glomerulus QTL 4 2 2.4 0.0082 37018 D2Rat14 Renal histology number of superficial glomeruli present in the renal cortex corticis zone but without direct surface contact counted in three mid-coronal sections for each animal increased surface glomeruli Proteinuria;Albuminuria 730279 14638907 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731168 rat Bp154 Blood pressure QTL 154 1 3.4 2969 Klk1l 43424 D1Wox10 621323 Phox2a Blood pressure systolic systolic blood pressure measured by tail-cuff method; diet contained 1% NaCl in drinking water decreased systemic arterial blood pressure Hypertension 730283 14623828 1 94624828 220639653 1 - by flanking markers 1 94702938 220803676 1 - by flanking markers 731189 SHRSP.WKY-(Klk1-D1Rat116)/Izm backcross
731169 rat Bp153 Blood pressure QTL 153 1 0.001 37974 D1Rat211 36550 D1Rat12 Blood pressure systolic measured by both tail-cuff and radiotelemetry methods; diet consisted of 2% NaCl diet for 24 days increased systemic arterial blood pressure Hypertension 728381 14597851 Bp95 17 1147796 3643283 1 - by flanking markers 17 1147796 3643283 1 - by flanking markers 731190 SS.LEW-(D1Rat211-D1Rat18)/Mco backcross
731170 rat Pur3 Proteinuria QTL 3 15 2.3 5.0E-4 37702 D15Rat66 Renal function urine albumin level total urinary protein excretion was determined by Bradford method proteinuria Proteinuria 730279 14638907 15 1 44351302 3 - by peak only 15 0 44352549 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731171 rat Glom6 Glomerulus QTL 6 9 2.8 3.0E-4 35691 D9Rat5 Renal histology number of superficial glomeruli present in the renal cortex corticis zone but without direct surface contact counted in three mid-coronal sections for each animal increased surface glomeruli Albuminuria;Proteinuria 730279 14638907 9 62686917 107686917 3 - by peak only 9 62870336 107870336 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731172 rat Bp151 Blood pressure QTL 151 3 0.04 10260 D3Rat52 39050 D3Rat130 Blood pressure decreased systemic arterial blood pressure Hypertension 724791 14517349 3 14051872 44551542 1 - by flanking markers 3 13948245 44447914 1 - by flanking markers 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd backcross
731173 rat Uae22 Urinary albumin excretion QTL 22 6 10.1 38608 D6Rat106 36191 D6Rat6 36990 D6Rat12 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 1642911;1600609;730279 17953514;17167120;14638907 2151;3851;70907 Arg2;Tgfb3;Actn1 6 68036028 123455207 1 - by flanking markers 6 68039356 147642806 2 - by one flank and peak markers 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731174 rat Uae23 Urinary albumin excretion QTL 23 7 2.4 0.0042 35304 D7Rat4 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 730279 14638907 7 112114092 143002779 3 - by peak only 7 112190529 143082968 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731175 rat Uae20 Urinary albumin excretion QTL 20 1 3.5 0.0018 35909 D1Rat74 35457 D1Rat90 35945 D1Rat75 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 730279 14638907 1 227005311 267111153 1 - by flanking markers 1 227169335 267322172 1 - by flanking markers 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731176 rat Glom5 Glomerulus QTL 5 7 2.5 0.0035 35118 D7Rat7 Renal histology number of superficial glomeruli present in the renal cortex corticis zone but without direct surface contact counted in three mid-coronal sections for each animal increased surface glomeruli Proteinuria;Albuminuria 730279 14638907 7 103894800 143002779 3 - by peak only 7 103929030 143082968 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731177 rat Uae26 Urinary albumin excretion QTL 26 15 2.4 0.025 40106 D15Rat102 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 730279 14638907 15 75200650 109758846 3 - by peak only 15 75216431 109774626 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731178 rat Oia7 Oil induced arthritis QTL 7 4 1.0E-4 60413 D4Got126 60422 D4Got136 Joint/bone inflammation oil induced induced by an intradermal injection of incomplete Freund's adjuvant-oil; arthritis development monitored using a macroscopic scoring system ranging from 0 to 4 for each of the four limbs joint swelling Arthritis, Rheumatoid 1642519;2307198;730281 17665455;18540828;12915467 2976;2977;2978;619983;620537 Klrc1;Klrc2;Klrd1;C1s;C3ar1 additive Oia2 4 159298584 160528447 1 - by flanking markers 4 159543521 160773383 1 - by flanking markers 731193 DA.PVG-(D4Rat141-D4Mgh11) backcross
731179 rat Mamtr3 Mammary tumor resistance QTL 3 2 1.0E-4 67800 D2Uwm17 36470 D2Rat16 Mammary tumor resistance treated with 7,12-dimethylbenz(a)anthracene (DMBA) for 15 weeks; total number of mammary carcinomas > 3 x 3 mm in diameter enumerated absent spiral limbus Breast Neoplasms 724790 14522903 recessive Mcs1 2 32051319 43376635 1 - by flanking markers 2 31971688 43304868 1 - by flanking markers 728391 WF.COP-(D2Rat253-D2Uwm17/Uwm intercross WFxCOP
731180 rat Bp152 Blood pressure QTL 152 3 0.03 728034 D3Chm63 35795 D3Rat26 Blood pressure increased systemic arterial blood pressure Hypertension 724791 14517349 3 51161661 90573782 1 - by flanking markers 3 45470008 90470008 4 - by one flank marker only 731194 SS.LEW-(D3Chm64-D3Rat17)/Ayd backcross
731181 rat Uae27 Urinary albumin excretion QTL 27 X 2.7 0.0059 36111 DXRat8 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 730279 14638907 X 18886934 63886934 3 - by peak only X 18940428 63940428 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731182 rat Uae24 Urinary albumin excretion QTL 24 8 6.4 35296 D8Rat53 36904 D8Rat19 36235 D8Rat35 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 730279 14638907 8 19815642 98451660 1 - by flanking markers 8 19815643 98470858 1 - by flanking markers 731185;731186 MWF/Fub;SHR/Fub backcross MWF/FubxSHR/Fub
731183 rat Pia20 Pristane induced arthritis QTL 20 14 3.55 35713 D14Rat11 37030 D14Rat3 33551 D14Mit6 Joint/bone inflammation pristane induced arthritis induced by intradermal injection of pristane (2,6,10,14-tetramethylpentadecane) at the base of the tail; secretion of cartilage oligomeric matrix protein (COMP) from new-formed/eroded cartilage to plasma analysed by competitive ELISA joint swelling Arthritis, Rheumatoid 730280 14624754 Pia6 14 10340377 41608939 1 - by flanking markers 14 10340272 41611330 1 - by flanking markers 731195 DA.E3-(D14Wox8-D14Rat64)/Rhd backcross
731184 rat Mamtr4 Mammary tumor resistance QTL 4 2 3.0E-4 36205 D2Rat2 728007 D2M13Mit286 Mammary tumor resistance treated with 7,12-dimethylbenz(a)anthracene (DMBA) for 15 weeks; total number of mammary carcinomas > 3 x 3 mm in diameter enumerated absent spiral limbus Breast Neoplasms 724790 14522903 semidominant Mcs1 2 14747817 59747817 4 - by one flank marker only 2 14668186 59668186 4 - by one flank marker only 728385 WF.COP-(D2Rat2-D2M13Mit286/Uwm intercross WFxCOP
724513 rat Uae14 Urinary albumin excretion QTL 14 6 6.5 36191 D6Rat6 37280 D6Rat104 36990 D6Rat12 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 634633 12799471 6 88723578 123455031 1 - by flanking markers 6 88726906 139344326 2 - by one flank and peak markers 10041;631696 SS/Jr;SHR/FubRkb intercross SS/JrxSHR/Rkb
724514 rat Uae15 Urinary albumin excretion QTL 15 8 2.9 40746 D8Rat162 35987 D8Rat30 36117 D8Rat46 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 634633 12799471 8 30878636 74178909 1 - by flanking markers 8 30887403 74197955 1 - by flanking markers 10041;631696 SS/Jr;SHR/FubRkb intercross SS/JrxSHR/Rkb
724515 rat Uae16 Urinary albumin excretion QTL 16 9 8.0 8.0 36027 D9Rat3 34013 D9Mit3 35691 D9Rat5 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 634633 12799471 9 55476135 99799760 1 - by flanking markers 9 55623117 100009240 1 - by flanking markers 10041;631696 SS/Jr;SHR/FubRkb intercross SS/JrxSHR/Rkb
724516 rat Uae17 Urinary albumin excretion QTL 17 10 3.6 41534 D10Rat143 37460 D10Rat93 35108 D10Rat30 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 634633 12799471 10 45617800 81887390 2 - by one flank and peak markers 10 81901760 89241864 1 - by flanking markers 10041;631696 SS/Jr;SHR/FubRkb intercross SS/JrxSHR/Rkb
724517 rat Uae18 Urinary albumin excretion QTL 18 11 3.7 35565 D11Rat20 36065 D11Rat6 33792 D11Mit2 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 634633 12799471 11 16670176 45232986 1 - by flanking markers 11 16670176 45290531 1 - by flanking markers 10041;631696 SS/Jr;SHR/FubRkb intercross SS/JrxSHR/Rkb
724518 rat Uae19 Urinary albumin excretion QTL 19 19 5.5 33618 D19Mit7 37042 D19Rat19 35881 D19Rat11 Renal function urine albumin level measured by rat-specific ELISA albuminuria Albuminuria 634633 12799471 19 7813671 45090802 1 - by flanking markers 19 7818497 45095501 1 - by flanking markers 10041;631696 SS/Jr;SHR/FubRkb intercross SS/JrxSHR/Rkb
724519 rat Bp144 Blood pressure QTL 144 20 0.001 61303 D20Utr1 3876 Tnf 61303 D20Utr1 Blood pressure mean arterial averaging direct measurements of carotid arterial pressure in five or six males increased systemic arterial blood pressure Hypertension 619638 8938440 20 1 3663618 4 - by one flank marker only 20 0 3663010 4 - by one flank marker only 61098 BXH intercross ACI/KunxBN/M
724520 rat Bp145 Blood pressure QTL 145 1 2.1 0.0024 38782 D1Rat136 Blood pressure systolic measured at 14 weeks of age by a tail-cuff method in awake animals increased systemic arterial blood pressure Hypertension 634618 12397040 1 15147212 60147212 3 - by peak only 1 15150157 60150157 3 - by peak only 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724521 rat Uae1 Urinary albumin excretion QTL 1 1 3.8 1.0E-4 36765 D1Rat27 39314 D1Rat216 36023 D1Rat38 Renal function urine albumin level urine collected over a 24-h period from animals in metabolic cages; albumin concentrations measured by a rat-specific ELISA proteinuria Proteinuria;Cardiovascular Diseases 634618 12397040 1 90282040 185923619 1 - by flanking markers 1 90360152 186073500 1 - by flanking markers 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724522 rat Bp146 Blood pressure QTL 146 4 2.2 0.0021 35325 D4Rat41 Blood pressure systolic measured at 14 weeks of age by a tail-cuff method in awake animals increased systemic arterial blood pressure Hypertension 634618 12397040 4 74123346 119123346 3 - by peak only 4 74367827 119367827 3 - by peak only 724569;724570 MWF/FubRkb;LEW/Rkb
724523 rat Tsu1 Thymus enlargement suppressive QTL 1 3 3.84 33668 D3Mit13 3632 Scn2a1 2279 Cat Gland mass thymus thymus ratio was calculated by dividing the thymus weight by body weight small thymus Thymus Hyperplasia 634729 9234381 45096 3 47588413 129751875 2 - by one flank and peak markers 3 47619172 115901518 1 - by flanking markers 61118;724571 BUF/Mna;MITE/Mna backcross BUF/MnaxMITE/Mna
724524 rat Uae2 Urinary albumin excretion QTL 2 6 2.7 5.0E-4 36990 D6Rat12 34306 D6Mgh5 38246 D6Rat71 Renal function urine albumin level urine collected over a 24-h period from animals in metabolic cages; albumin concentrations measured by a rat-specific ELISA proteinuria Proteinuria;Cardiovascular Diseases 634618 12397040 6 76380261 114031923 1 - by flanking markers 6 76383387 114035541 1 - by flanking markers 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724525 rat Bp147 Blood pressure QTL 147 5 4.3 1.0E-4 35825 D5Rat41 Blood pressure systolic measured at 14 weeks of age by a tail-cuff method in awake animals increased systemic arterial blood pressure Hypertension 634618 12397040 5 132950669 173096209 3 - by peak only 5 132960744 173106704 3 - by peak only 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724526 rat Uae3 Urinary albumin excretion QTL 3 12 4.9 1.0E-4 39744 D12Rat59 38052 D12Rat37 36538 D12Rat7 Renal function urine albumin level urine collected over a 24-h period from animals in metabolic cages; albumin concentrations measured by a rat-specific ELISA proteinuria Proteinuria;Cardiovascular Diseases 634618 12397040 12 10701028 31418398 2 - by one flank and peak markers 12 4864215 10731129 1 - by flanking markers 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724527 rat Bp148 Blood pressure QTL 148 10 1.0E-4 631289 D10M11Mit119 37996 D10Rat127 Blood pressure increased systemic arterial blood pressure Hypertension 704345 12939233 10 42272656 87272656 4 - by one flank marker only 10 42287010 87287010 4 - by one flank marker only 724572 SS.LEW-(D10Wox51-D10Rat27)/Ayd
724528 rat Uae4 Urinary albumin excretion QTL 4 17 4.9 1.0E-4 36011 D17Rat17 35473 D17Rat58 40276 D17Rat133 Renal function urine albumin level urine collected over a 24-h period from animals in metabolic cages; albumin concentrations measured by a rat-specific ELISA proteinuria Cardiovascular Diseases;Proteinuria 634618 12397040 17 42344830 81039660 1 - by flanking markers 17 42347672 81050481 1 - by flanking markers 724569;724570 MWF/FubRkb;LEW/Rkb intercross MWF/RkbxLEW/Rkb
724529 rat Cm16 Cardiac mass QTL 16 1 2.7 38420 D1Rat189 37168 D1Rat158 36007 D1Rat36 Cardiac mass calculated by adjusting heart weight for differences in body weight by regression analysis increased heart weight;increased systemic arterial blood pressure Hypertension;Heart Diseases 634617 12707388 1 87465281 153578547 1 - by flanking markers 1 87543397 153656953 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724530 rat Bp149 Blood pressure QTL 149 10 1.0E-4 34896 D10Rat17 36958 D10Rat9 Blood pressure increased systemic arterial blood pressure Hypertension 704345 12939233 10 95066219 99588446 1 - by flanking markers 10 95080680 99602816 1 - by flanking markers 724575 SS.LEW-(D10Rat17-D10Mgh1)/Ayd
724531 rat Uae5 Urinary albumin excretion QTL 5 1 4.0 37168 D1Rat158 36703 D1Rat86 66610 D1Mco35 Renal function urine albumin level determined by SDS-PAGE albuminuria;proteinuria Albuminuria;Proteinuria 634617 12707388 1 153578442 259173490 1 - by flanking markers 1 153656849 259439404 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724532 rat Cm17 Cardiac mass QTL 17 3 2.0 41442 D3Rat160 Cardiac mass calculated by adjusting heart weight for differences in body weight by regression analysis increased heart weight Heart Diseases 634617 12707388 3 96192217 141192217 3 - by peak only 3 96097691 141097691 3 - by peak only 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724533 rat Rf51 Renal function QTL 51 1 5.3 2.0E-4 34194 D1Mgh14 33945 D1Mit18 33903 D1Mit7 Renal function renal blood flow the urinary bladder was catheterized to collect a urine sample; a blood sample was collected at the midpoint of the clearance study for determination of plasma inulin, PAH, and creatinine concentrations decreased renal glomerular filtration rate;increased renal vascular resistance;decreased renal plasma flow rate Kidney Diseases 619628 10545438 codominant 1 224426393 263698966 1 - by flanking markers 1 224590416 263910012 1 - by flanking markers 61000;61103 SHR;WKY intercross SHRxWKY
724534 rat Uae6 Urinary albumin excretion QTL 6 2 10.0 66661 D2Mco18 35915 D2Rat61 36773 D2Rat50 Renal function urine albumin level determined by SDS-PAGE proteinuria;glomerulosclerosis;albuminuria Glomerulosclerosis, Focal;Proteinuria;Albuminuria 634617 12707388 2 79796833 227150248 1 - by flanking markers 2 79741795 227136928 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724535 rat Cm18 Cardiac mass QTL 18 4 2.6 40642 D4Rat195 Cardiac mass calculated by adjusting heart weight for differences in body weight by regression analysis increased heart weight Heart Diseases 634617 12707388 4 121375218 166375218 3 - by peak only 4 121620060 166620060 3 - by peak only 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724536 rat Uae7 Urinary albumin excretion QTL 7 6 3.5 11241 D6Mit3 10361 D6Wox13 66623 D6Uia5 Renal function urine albumin level determined by SDS-PAGE albuminuria;proteinuria Proteinuria;Albuminuria 634617 12707388 6 75049527 136452267 1 - by flanking markers 6 75052653 136458454 1 - by flanking markers 724573;724574 SS/JrMco;SHR/NHsd intercross SS/JrMcoxSHR/NHsd
724537 rat Niddm52 Non-insulin dependent diabetes mellitus QTL 52 7 0.02 33648 D7Mit5 10939 D7Mit27 Glucose level determined using the oral glucose tolerance test after overnight starvation impaired glucose tolerance Glucose Intolerance 619670 11381614 7 85089895 98955278 1 - by flanking markers 7 85110626 98989508 1 - by flanking markers 69643;734526 F344/DuCrlCrlj;OLETF/Got intercross OLETF/OtkxF344/Crj
737818 rat Hcar12 Hepatocarcinoma resistance QTL 12 3 2.6 35745 D3Rat48 34411 D3Mgh14 35745 D3Rat48 Liver tumor resistance nodule number neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 629566 12154055 Hcr9,Hcr10,Hcr11 3 25775548 118863223 1 - by flanking markers 3 25672049 118768796 1 - by flanking markers 737690;737691 F344/Crli;BN/Crli backcross BN/CrlixF344/Crli
737819 rat Hcas4 Hepatocarcinoma susceptibility QTL 4 16 4.43 33848 D16Mit2 10842 D16Mgh5 Liver tumor susceptibility nodule number neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal olfactory -discrimination memory Carcinoma, Hepatocellular 629566 12154055 Hcs3 16 4304396 50266190 1 - by flanking markers 16 4304394 50266265 1 - by flanking markers 737690;737691 F344/Crli;BN/Crli backcross BN/CrlixF344/Crli
737820 rat Alc9 Alcohol consumption QTL 9 10 2.2 34361 D10Mgh25 39082 D10Rat118 41276 D10Rat182 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 731212;4890458 14634485;20705418 2401;61836;1304560;1311614;1359733;1563691 Crebbp;Clcn7;Fahd1;Gnptg;Trap1;Mapk8ip3 additive Alc4,Alc5,Alc6,Alc7,Alc8,Alc10,Alc11,Alc12,Alc13 10 5090008 19648894 1 - by flanking markers 10 5090008 19649943 1 - by flanking markers 631844;631845 HAD1;LAD1 Intercross HAD1xLAD1
737821 rat Hcar9 Hepatocarcinoma resistance QTL 9 4 3.7 35817 D4Rat40 34338 D4Mgh11 34174 D4Mgh7 Liver tumor resistance nodule number neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 629566 12154055 Hcr10,Hcr11 4 106554769 171204531 1 - by flanking markers 4 106799250 171449467 1 - by flanking markers 737690;737691 F344/Crli;BN/Crli backcross BN/CrlixF344/Crli
737822 rat Alc10 Alcohol consumption QTL 10 12 2.2 11051 D12Mit2 34086 D12Mgh9 36490 D12Rat18 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 731212 14634485 additive Alc4,Alc5,Alc6,Alc7,Alc8,Alc9,Alc11,Alc12,Alc13 12 20932559 41447890 1 - by flanking markers 12 20922171 41311278 1 - by flanking markers 631844;631845 HAD1;LAD1 Intercross HAD1xLAD1
737823 rat Alc12 Alcohol consumption QTL 12 10 4.5 41276 D10Rat182 35012 D10Rat46 41524 D10Rat180 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 731212 14634485 additive Alc4,Alc5,Alc6,Alc7,Alc8,Alc9,Alc10,Alc11,Alc13 10 17515123 19815204 1 - by flanking markers 10 17516172 19816253 1 - by flanking markers 731187;731188 HAD2;LAD2 Intercross HAD2xLAD2
737824 rat Hcar10 Hepatocarcinoma resistance QTL 10 8 2.9 36117 D8Rat46 35905 D8Rat21 33973 D8Mit2 Liver tumor resistance nodule number neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 629566 12154055 Hcr9,Hcr11,Hcr12 8 43313902 87122960 1 - by flanking markers 8 43323018 87142415 1 - by flanking markers 737690;737691 F344/Crli;BN/Crli backcross BN/CrlixF344/Crli
737825 rat Alc13 Alcohol consumption QTL 13 16 4.5 33848 D16Mit2 37854 D16Rat30 45312 D16Rat124 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 731212 14634485 additive Alc4,Alc5,Alc6,Alc7,Alc8,Alc9,Alc10,Alc11,Alc12 16 4304396 16536977 1 - by flanking markers 16 4304394 16536975 1 - by flanking markers 731187;731188 HAD2;LAD2 Intercross HAD2xLAD2
737826 rat Alc11 Alcohol consumption QTL 11 16 3.2 33848 D16Mit2 40234 D16Rat60 34066 D16Mgh1 Consumption level alcohol preference in separate cage with free choice of water or 10% (v/v) of ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 3 days over three weeks alcohol preference Alcoholism 731212 14634485 additive Alc4,Alc5,Alc6,Alc7,Alc8,Alc9,Alc10,Alc12,Alc13 16 4304396 64081533 1 - by flanking markers 16 4304394 64081608 1 - by flanking markers 631844;631845 HAD1;LAD1 Intercross HAD1xLAD1
737827 rat Hcar11 Hepatocarcinoma resistance QTL 11 6 4.4 34835 D6Rat28 35198 D6Rat11 36665 D6Rat14 Liver tumor resistance nodule number neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 629566 12154055 Hcr9,Hcr10,Hcr12 6 41300997 147636619 2 - by one flank and peak markers 6 41303950 115242195 1 - by flanking markers 737690;737691 F344/Crli;BN/Crli backcross BN/CrlixF344/Crli
737828 rat Hcas3 Hepatocarcinoma susceptibility QTL 3 1 4.9 33959 D1Mit3 37982 D1Rat223 35615 D1Rat70 Liver tumor susceptibility nodule number neoplastic nodules were measured by the method in livers of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal olfactory -discrimination memory Carcinoma, Hepatocellular 629566 12154055 Hcs4 1 146971846 228781113 1 - by flanking markers 1 147050253 228945136 1 - by flanking markers 737690;737691 F344/Crli;BN/Crli backcross BN/CrlixF344/Crli
737856 rat Edpm10 Estrogen-dependent pituitary mass QTL 10 14 2.83 6.5 Gland mass pituitary rats were given subcutaneous implants containing crystalline diethylstilbestrol (DES), 70 days later the pituitaries were removed and weighed pituitary gland hyperplasia Pituitary Neoplasms 61074 9337394 10008;61109 BN/SsNHsd;F344/NHsd intercross
738005 rat Anxrr11 Anxiety related response QTL 11 18 3.4 37568 D18Rat55 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the closed arms of the maze hyperactivity Anxiety Disorders;Hyperkinesis 737695 14739700 Arr3,Arr4,Arr5,Arr6,Arr7,Arr8,Arr9,Arr10 18 32356601 77356601 3 - by peak only 18 32428833 77428833 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738006 rat Anxrr14 Anxiety related response QTL 14 1 4.0 3.5E-4 32.0 34074 D1Mgh8 Anxiety response plus maze-open arm activity was measured in the elevated plus maze; average time spent in the open arms of the maze was analyzed abnormal response to new environment 731213 12972953 Arr12,Arr13,Arr15 1 133624682 178624682 3 - by peak only 1 133703088 178703088 3 - by peak only 61103;738038 WKY;HEP intercross WKYxHEP
738007 rat Anxrr7 Anxiety related response QTL 7 2 4.4 41300 D2Rat221 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open and closed arms of the maze increased anxiety-related response;hypoactivity Anxiety Disorders 737695 14739700 Arr3,Arr4,Arr5,Arr6,Arr8,Arr9,Arr10,Arr11 2 123254875 168254875 3 - by peak only 2 123204750 168204750 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738008 rat Hcar14 Hepatocarcinoma resistance QTL 14 18 4.3 38146 D18Rat50 39278 D18Rat44 36816 D18Rat12 Liver tumor resistance nodule number number of neoplastic nodules, mean volume of lesions and volume fraction were measured in the liver of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 737884 15185337 18 53847683 86863411 1 - by flanking markers 18 53911626 86936861 1 - by flanking markers 60998;70509 COP;F344/N intercross
738009 rat Sach4 Saccharine consumption QTL 4 4 4.9 1.6E-5 46.0 36540 D4Rat24 10048 D4Mit20 37100 D4Rat52 Consumption level saccharin preference in separate cage with free choice of water or 7.5 mM saccharine; consumption scores (grams/kg/day) were averaged; the amounts of saccharine consumed every 2 days over two weeks saccharin preference;saccharin versus water Alcoholism 731213 12972953 3197 Npy Alc14,Alc16,Alc15,Alc17 4 97211920 158108528 2 - by one flank and peak markers 4 58698051 158353464 1 - by flanking markers 61103;738038 WKY;HEP intercross WKYxHEP
738010 rat Lnnr3 Liver neoplastic nodule remodeling QTL 3 2 2.94 41538 D2Rat199 40786 D2Rat187 Liver neoplastic nodule remodeling frequency liver tumor nodule remodeling is characterized by the presence of irregular nodule margins and irregular GST-P enzyme staining pattern, carried out in livers of rats killed at 32 weeks following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal Rosenthal canal morphology Liver Neoplasms 737884 15185337 2 1 41032214 4 - by one flank marker only 2 0 40952583 4 - by one flank marker only 60998;70509 COP;F344/N intercross
738011 rat Anxrr9 Anxiety related response QTL 9 8 6.1 35429 D8Rat7 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open and closed arms of the maze hypoactivity;increased anxiety-related response Anxiety Disorders 737695 14739700 Arr3,Arr4,Arr5,Arr6,Arr7,Arr8,Arr10,Arr11 8 98332663 129041809 3 - by peak only 8 98352401 129061546 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738012 rat Anxrr3 Anxiety related response QTL 3 2 3.8 37880 D2Rat94 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open arms of the maze increased anxiety-related response Anxiety Disorders 737695 14739700 Arr4,Arr5,Arr6,Arr7,Arr8,Arr9,Arr10,Arr11 2 8682344 53682344 3 - by peak only 2 8602760 53602760 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738013 rat Alc15 Alcohol consumption QTL 15 2 4.1 2.2E-4 18.0 38466 D2Rat118 Consumption level alcohol amount in separate cage animals were given 10% ethanol as sole choice; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed were measured over 2 days abnormal alcohol consumption Alcoholism 731213 12972953 Alc14,Alc16,Alc17 2 192489056 237489056 3 - by peak only 2 192452157 237452157 3 - by peak only 61103;738038 WKY;HEP intercross WKYxHEP
738014 rat Anxrr15 Anxiety related response QTL 15 8 3.6 0.005 32.0 36327 D8Rat2 Anxiety response plus maze-center activity was measured in the elevated plus maze; average time spent in the center of the maze was analyzed abnormal response to new environment 731213 12972953 Arr12,Arr13,Arr14 8 100915338 129041809 3 - by peak only 8 100935076 129061546 3 - by peak only 61103;738038 WKY;HEP intercross WKYxHEP
738015 rat Pia9 Pristane induced arthritis QTL 9 4 0.048 10561 D4Wox20 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis); observations were made twice weekly for 6 weeks joint swelling Arthritis, Rheumatoid 629560 12571866 Pia5 4 81916057 126916057 3 - by peak only 737859 DA.PVG.1AV1-(D4Mgh17-D4Rat56)
738016 rat Alc16 Alcohol consumption QTL 16 4 3.6 1.5E-4 35.0 36540 D4Rat24 10048 D4Mit20 35070 D4Rat57 Consumption level alcohol preference in separate cage with free choice of water or 10% ethanol solution; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed were measured every 2 days over two weeks alcohol preference Alcoholism 731213 12972953 3197 Npy Alc14,Sach4,Alc15,Alc17 4 110970166 158108528 2 - by one flank and peak markers 4 58698051 158353464 1 - by flanking markers 61103;738038 WKY;HEP intercross WKYxHEP
738017 rat Hcas7 Hepatocarcinoma susceptibility QTL 7 15 2.91 38922 D15Rat38 41114 D15Rat89 35350 D15Rat3 Liver tumor susceptibility nodule number number of neoplastic nodules, mean volume of lesions and volume fraction were measured in the liver of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal olfactory -discrimination memory Carcinoma, Hepatocellular 737884 15185337 15 2306220 43057384 2 - by one flank and peak markers 15 2306221 43088763 2 - by one flank and peak markers 60998;70509 COP;F344/N intercross
738018 rat Anxrr4 Anxiety related response QTL 4 5 5.1 35348 D5Rat45 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open field of the maze decreased anxiety-related response Anxiety Disorders 737695 14739700 Arr3, Arr5, Arr6, Arr7, Arr8, Arr9, Arr10, Arr11 5 136765530 173096209 3 - by peak only 5 136775744 173106704 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738019 rat Anxrr10 Anxiety related response QTL 10 3 3.9 39912 D3Rat180 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open and closed arms of the maze hyperactivity Anxiety Disorders;Hyperkinesis 737695 14739700 Arr3, Arr4, Arr5, Arr6, Arr7, Arr8, Arr9, Arr11 3 36264666 81264666 3 - by peak only 3 36161038 81161038 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738020 rat Pia8 Pristane induced arthritis QTL 8 1 4.7 34035 D1Mit15 11144 D1Wox11 34662 D1Mgh2 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 14 weeks by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 4 (1 point for swelling and redness of one joint, 2 for two joints involved, 3 for more than two joints and 4 for severe arthritis) joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;629570 18540828;18606636;16804090;11090241 dominant 45992 1 1 64145956 2 - by one flank and peak markers 1 1908351 64224067 1 - by flanking markers 631161 DXE3/Ztm intercross
738021 rat Hcar13 Hepatocarcinoma resistance QTL 13 4 4.3 41102 D4Rat151 41578 D4Rat145 Liver tumor resistance nodule number number of neoplastic nodules, mean volume of lesions and volume fraction were measured in the liver of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure impaired memory in olfactory discrimination test Carcinoma, Hepatocellular 737884 15185337 4 1 29414068 4 - by one flank marker only 4 0 29452347 4 - by one flank marker only 60998;70509 COP;F344/N intercross
738022 rat Anxrr13 Anxiety related response QTL 13 1 4.6 3.9E-4 24.0 34381 D1Mgh7 Anxiety response open field inner locomotion activity was measured in the open field enclosure; average time spent in the inner squares of the open field was analyzed abnormal response to new environment 731213 12972953 Arr12,Arr14,Arr15 1 83945235 128945235 3 - by peak only 1 84023578 129023578 3 - by peak only 61103;738038 WKY;HEP intercross WKYxHEP
738023 rat Alc17 Alcohol consumption QTL 17 6 3.1 0.003 38.0 35963 D6Rat46 Consumption level alcohol preference in separate cage with free choice of water or 10% ethanol solution; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed was measured every 2 days over two weeks alcohol preference Alcoholism 731213 12972953 Alc14,Sach4,Sach5,Alc15,Alc16 6 1 35786687 3 - by peak only 6 0 35786687 3 - by peak only 61103;738038 WKY;HEP intercross WKYxHEP
738024 rat Sach5 Saccharine consumption QTL 5 6 3.9 3.9E-4 31.0 40624 D6Rat148 Consumption level saccharin preference in separate cage with free choice of water or 7.5 mM saccharine solution; consumption scores (grams/kg/day) were averaged; the amounts of saccharine consumed were measured every 2 days over two weeks saccharin preference;saccharin versus water Alcoholism 731213 12972953 Alc14,Sach4,Alc15,Alc16,Alc17 6 1 43326782 3 - by peak only 6 0 43329735 3 - by peak only 61103;738038 WKY;HEP intercross WKYxHEP
738025 rat Stresp3 Stress response QTL 3 X 4.61 0.0066 40448 DXRat127 10609 DXWox31 41530 DXRat104 Stress response defensive burying - approach behavioral response to a stressful stimulus was measured with the defensive burying test; this trait concerns the number of approaches made to an electrical stimulus before beginning the defensive burying response increased anxiety-related response;abnormal coping response 737687 14722724 additive Arr3,Arr4 X 124590224 160699376 2 - by one flank and peak markers X 124663657 160775580 2 - by one flank and peak markers 61103;70509 WKY;F344/N intercross WKYxF344
738026 rat Lnnr5 Liver neoplastic nodule remodeling QTL 5 13 3.29 33733 D13Mit2 40568 D13Rat152 36506 D13Rat32 Liver neoplastic nodule remodeling frequency liver tumor nodule remodeling is characterized by the presence of irregular nodule margins and irregular GST-P enzyme staining pattern, carried out in livers of rats killed at 32 weeks following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal Rosenthal canal morphology Liver Neoplasms 737884 15185337 13 62072299 94306205 2 - by one flank and peak markers 13 62086380 94320616 2 - by one flank and peak markers 60998;70509 COP;F344/N intercross
738027 rat Lnnr6 Liver neoplastic nodule remodeling QTL 6 13 3.3 36506 D13Rat32 40568 D13Rat152 40568 D13Rat152 Liver neoplastic nodule remodeling frequency liver tumor nodule remodeling is characterized by the presence of irregular nodule margins and irregular GST-P enzyme staining pattern, carried out in livers of rats killed at 32 weeks following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal Rosenthal canal morphology Liver Neoplasms 737884 15185337 13 78189125 111154910 4 - by one flank marker only 13 78203445 111348958 4 - by one flank marker only 60998;70509 COP;F344/N intercross
738028 rat Anxrr12 Anxiety related response QTL 12 1 4.9 1.0E-5 29.0 34074 D1Mgh8 Anxiety response plus maze-center activity was measured in the elevated plus maze; average time spent in the center of the maze abnormal response to new environment 731213 12972953 Arr13,Arr14,Arr15 1 133624682 178624682 3 - by peak only 1 133703088 178703088 3 - by peak only 61103;738038 WKY;HEP intercross WKYxHEP
738029 rat Stresp2 Stress response QTL 2 X 3.4 4.0E-4 39210 DXRat64 10558 DXWox30 40448 DXRat127 Stress response defensive burying - approach behavioral response to a stressful stimulus was measured with the defensive burying test; the approach trait concerns the number of approaches made to an electrical stimulus before beginning the defensive burying response increased anxiety-related response;abnormal coping response 737687 14722724 additive Arr3,Arr5 X 11470971 160699376 2 - by one flank and peak markers X 11476528 160775580 2 - by one flank and peak markers 61103;70509 WKY;F344/N intercross WKYxF344
738030 rat Anxrr8 Anxiety related response QTL 8 7 4.1 38606 D7Rat110 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open and closed arms of the maze increased anxiety-related response;hypoactivity Anxiety Disorders 737695 14739700 Arr3,Arr4,Arr5,Arr6,Arr7,Arr9,Arr10,Arr11 7 50941627 95941627 3 - by peak only 7 50962323 95962323 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738031 rat Alc14 Alcohol consumption QTL 14 4 7.6 3.0E-5 61.0 36540 D4Rat24 10048 D4Mit20 37868 D4Rat124 Consumption level alcohol preference in separate cage with free choice of water or 5% ethanol; consumption scores (grams/kg/day) were averaged; the amounts of ethanol consumed every 2 days over two weeks alcohol preference Alcoholism 731213 12972953 3197 Npy Alc16,Sach4,Alc15,Alc17 4 77208508 158108528 2 - by one flank and peak markers 4 58698051 158353464 1 - by flanking markers 61103;738038 WKY;HEP intercross WKYxHEP
738032 rat Hcas5 Hepatocarcinoma susceptibility QTL 5 1 3.12 40486 D1Rat437 36169 D1Rat89 35945 D1Rat75 Liver tumor susceptibility nodule number number of neoplastic nodules, mean volume of lesions and volume fraction were measured in the liver of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal olfactory -discrimination memory Carcinoma, Hepatocellular 737884 15185337 1 180678929 265343617 1 - by flanking markers 1 180818844 265554662 1 - by flanking markers 60998;70509 COP;F344/N intercross
738033 rat Anxrr6 Anxiety related response QTL 6 7 4.1 37004 D7Rat181 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open arms of the maze abnormal anxiety-related response Anxiety Disorders 737695 14739700 Arr3,Arr4,Arr5,Arr7,Arr8,Arr9,Arr10,Arr11 7 18504784 63504784 3 - by peak only 7 18525055 63525055 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738034 rat Anxrr5 Anxiety related response QTL 5 6 5.9 39578 D6Rat117 Anxiety response open field inner locomotion performance in elevated plus-maze test for anxiety; this locus concerns the number of times the animal entered into the open arms of the maze decreased anxiety-related response Anxiety Disorders 737695 14739700 Arr3,Arr4,Arr6,Arr7,Arr8,Arr9,Arr10,Arr11 6 88615514 133615514 3 - by peak only 6 88619045 133619045 3 - by peak only 61100;61117 SHR/Ola;BN-Lx/Cub intercross SHR/OlaxBN-Lx/Cub
738035 rat Stresp1 Stress response QTL 1 X 4.96 1.1E-5 38374 DXRat67 39210 DXRat64 38374 DXRat67 Stress response defensive burying - coping animals behavioral response to a stressful stimulus was measured with the defensive burying test; the coping trait concerns the latency to and duration of the defensive burying response to an electric shock increased anxiety-related response;abnormal coping response 737687 14722724 Arr4,Arr5 X 11471200 62951569 1 - by flanking markers X 11476756 63005042 1 - by flanking markers 61103;70509 WKY;F344/N intercross WKYxF344
738036 rat Lnnr4 Liver neoplastic nodule remodeling QTL 4 13 3.64 35543 D13Rat21 35975 D13Rat7 Liver neoplastic nodule remodeling frequency liver tumor nodule remodeling is characterized by the presence of irregular nodule margins and irregular GST-P enzyme staining pattern, carried out in livers of rats killed at 32 weeks following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal Rosenthal canal morphology Liver Neoplasms 737884 15185337 13 1 43835207 2 - by one flank and peak markers 13 0 43849250 2 - by one flank and peak markers 60998;70509 COP;F344/N intercross
738037 rat Hcas6 Hepatocarcinoma susceptibility QTL 6 14 2.93 35713 D14Rat11 41138 D14Rat94 37828 D14Rat39 Liver tumor susceptibility nodule number number of neoplastic nodules, mean volume of lesions and volume fraction were measured in the liver of rats killed at 32 weeks of age following tumor induction by the resistant-hepatocyte protocol of diethylnitrosamine exposure abnormal olfactory -discrimination memory Carcinoma, Hepatocellular 737884 15185337 14 41608939 89192873 1 - by flanking markers 14 41611330 89212018 1 - by flanking markers 60998;70509 COP;F344/N intercross
737973 rat Pia21 Pristane induced arthritis QTL 21 20 3.3 11428 D20Wox3 37594 D20Rat41 Joint/bone inflammation pristane induced arthritis was induced at the age of 8-12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) increased resistance to induced joint inflammation Arthritis, Rheumatoid 631850;2307198;2300074;1582387 12817024;18540828;18606636;16804090 dominant Pia1 20 1 4740814 4 - by one flank marker only 20 3660872 4741041 1 - by flanking markers 737870 DA.E3-(D20Wox3-D20Mgh4)/Rhd
737974 rat Bp161 Blood pressure QTL 161 1 0.002 10923 D1Wox19 10165 D1Wox34 Blood pressure systolic systolic and diastolic blood pressures measured directly in 25 week old males through arterial cathetor inserted into the lower abdominal aorta increased systemic arterial blood pressure Hypertension 61051 9774356 Bp29, Bp160 1 168382329 185690881 1 - by flanking markers 1 168492992 185840762 1 - by flanking markers 629487 SHR.WKY-(D1Wox19-D1Wox34)/Njs
737975 rat Niddm60 Non-insulin dependent diabetes mellitus QTL 60 1 9.11 0.005 42553 D1Rat461 42550 D1Rat459 35457 D1Rat90 Body weight abdominal fat weight Measurements of animals at 18 weeks of age were taken as an index of obesity increased body weight Obesity 737696 14756694 Niddm58 1 266234605 267593558 1 - by flanking markers 1 266445650 267804643 1 - by flanking markers 737869 OLETF.BN-(D1Rat461-D1Rat459)/Got
737976 rat Pia24 Pristane induced arthritis QTL 24 6 44173 D6Wox5 37718 D6Rat90 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint swelling Arthritis, Rheumatoid 728382 14611807 Pia3 6 117361909 147636619 4 - by one flank marker only 6 117365657 147642806 4 - by one flank marker only 737873 DA.E3-(D6Wox5-D6Rat90)/Rhd
737977 rat Bp160 Blood pressure QTL 160 1 0.001 10923 D1Wox19 34011 D1Mit2 Blood pressure systolic systolic and diastolic blood pressures measured directly in 25 week old males through arterial cathetor inserted into the lower abdominal aorta decreased systemic arterial blood pressure;increased systemic arterial blood pressure Hypertension 61051 9774356 Bp29, Bp161 1 134980682 185690881 1 - by flanking markers 1 135059025 185840762 1 - by flanking markers 629482 WKY.SHR-(D1Wox19-D1Mit2)/Njs
737978 rat Pia23 Pristane induced arthritis QTL 23 4 5.3 10158 D4Arb16 34338 D4Mgh11 36143 D4Rat60 Joint/bone inflammation pristane induced arthritis was induced at the age of 8 to 12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint swelling Arthritis, Rheumatoid 631850;2300074;1582387 12817024;18606636;16804090 dominant Pia7 4 133939407 171204531 1 - by flanking markers 4 128160777 171449467 2 - by one flank and peak markers 737872 DA.E3-(D4Mit16-D4Mgh11)/Rhd
737979 rat Pia22 Pristane induced arthritis QTL 22 12 4.1 40986 D12Rat72 Joint/bone inflammation pristane induced arthritis was induced at the age of 8-12 week by an intradermal injection at the base of the tail with pristane (2,6,10,14-tetramethylpentadecane) and was monitored by a macroscopic scoring system of the four limbs ranging from 0 to 15 (1 point for each swollen or red toe, 1 point for midfoot digit and knuckle, and 5 points for a swollen ankle) joint inflammation Arthritis, Rheumatoid 631850;2300074;1582387;629560 12817024;18606636;16804090;12571866 61307 Ncf1 dominant Pia4 12 530865 45530865 3 - by peak only 12 389685 45389685 3 - by peak only 737871 DA.E3-(D12Got46-D12Rat26)/Rhd
1298080 rat Bp163 Blood pressure QTL 163 2 0.02 33739 D2Mit5 34461 D2Mgh12 Blood pressure systolic systolic, diastolic, and mean arterial blood pressure measured in congenic strain WKY/Gla.SHRSP/Gla-(D2Mit5-D2Mgh12) and compared to blood pressure of parental strain WKY increased systemic arterial blood pressure;increased heart weight Hypertension;Hypertension 2301356;68910;69705 18819818;10642295;9922389 Bp132 2 165636169 210636169 4 - by one flank marker only 2 165598923 210598923 4 - by one flank marker only 631280 WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc
1298081 rat Cia25 Collagen induced arthritis QTL 25 12 4.7 11053 D12Wox12 41962 D12Arb6 11053 D12Wox12 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 1600250;2300074;1582387;2307198;1285224 17329308;18606636;16804090;18540828;15334486 61307 Ncf1 recessive 12 1 43432656 3 - by peak only 12 20922167 36758138 1 - by flanking markers 631182;737892 DA/BklArbN;ACI/SegHsd intercross
1298082 rat Stresp4 Stress response QTL 4 4 34967 D4Rat15 36143 D4Rat60 36870 D4Rat33 Hormone level corticosterone late afternoon blood samples obtained from male rats and assayed for corticosterone levels; multiple steps were taken to minimize stress in the animals increased circulating corticosterone level 737981 15013833 4 47889730 149560340 1 - by flanking markers 4 48120304 149805181 1 - by flanking markers 61109;1298093 F344/NHsd;LEW/NHsd
1298083 rat Bp158 Blood pressure QTL 158 2 2.62 2167 Atp1a1 2263 Camk2d Blood pressure salt-loaded blood pressure measured by tail-cuff in F2 males maintained on high salt diet increased systemic arterial blood pressure Hypertension 61038 8040284 Bp10 2 196657749 224108082 1 - by flanking markers 2 196620502 224097854 1 - by flanking markers 10041;60992 SS/Jr;MNS
1298084 rat Thym4 Thymus enlargement QTL 4 1 10.68 2870 Igf2 11201 D1Mgh11 Gland mass thymus mean thymus ratios calculated for each marker locus and differences in this ratio between homozygous and heterozygous groups was analyzed using a Student's t-test. enlarged thymus Thymus Hyperplasia 70859 10792781 Ten1;Ten3 1 202906624 247906624 4 - by one flank marker only 1 203094689 248094689 4 - by one flank marker only 61118;61119 BUF/Mna;WKY/NCrlCrlj
1298085 rat Bp165 Blood pressure QTL 165 2 6.0E-4 37018 D2Rat14 34461 D2Mgh12 Blood pressure salt-loaded systolic measured in congenic strain WKY.SHRSP-(D2Rat14-D2Mgh12) and compared to parental strain WKY increased systemic arterial blood pressure Hypertension 728179 11980293 Bp13;Bp164 2 165636169 210636169 4 - by one flank marker only 2 165598923 210598923 4 - by one flank marker only 737865 WKY.SHRSP-(D2Rat14-D2Mgh12)
1298086 rat Bp156 Blood pressure QTL 156 5 69549 D5Uwm31 34583 D5Rjr1 Blood pressure salt-loaded systolic blood pressure measured on by tail-cuff method on rats fed a diet contining 2%NaCl decreased systemic arterial blood pressure Hypertension 1643012;619649 17938377;11875185 1308173 Dmrta2 Bp7 5 90916908 135916908 4 - by one flank marker only 5 90916119 135916119 4 - by one flank marker only 629578;728135;728145;728156;728157 SS.LEW-(D5Rat130-D5Mco10)/Jr;SS.LEW-(D5Uwm14-D5Uwm31)/Jr;SS.LEW-(D5Rat130-D5Rat108)/Jr;SS.LEW-(D5Mco34-D5Mco10)/Jr;SS.LEW-(D5Rat130-D5Mco19)/Jr
1298087 rat Iddm18 Insulin dependent diabetes mellitus QTL 18 6 1.0E-4 42809 D6Rat184 39052 D6Rat101 Glucose level insulin-dependent male and female rats examined for development of diabetes up to 30 weeks of age; diabetes determination based on glucosuria followed by measurement of blood glucose concentrations of >300 mg/dl on two consecutive days increased circulating cholesterol level;increased circulating triglyceride level;increased body weight Diabetes Mellitus, Insulin-Dependent 619685 11327715 Iddm8;Iddm16 6 121381065 135964844 1 - by flanking markers 6 121384812 135970706 1 - by flanking markers 1549799 BB.SHR-(D6Rat184-D6Rat3)/K
1298088 rat Edpm11 Estrogen-dependent pituitary mass QTL 11 9 2.5 36157 D9Rat31 Gland mass pituitary pituitaries weighed 70 days after rats given subcutaneous implants containing crystalline diethylstilbestrol (DES) pituitary gland hyperplasia;impaired basement membrane formation Pituitary Neoplasms 629550 11003699 9 1 39963583 3 - by peak only 9 0 39960906 3 - by peak only 10008;61109 BN/SsNHsd;F344/NHsd backcross
1298089 rat Scl14 Serum cholesterol level QTL 14 5 5.8 4.0E-4 12.0 33680 D5Mit13 Lipid level cholesterol plasma cholesterol, HDL-cholesterol, and total triglyceride were determined on euthanized animals following 16 hours fasting increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2479;3642 Cyp4a2;Scp2 5 115772027 160772027 3 - by peak only 5 115777253 160777253 3 - by peak only 634365;634366 SS/Hsd;SR/Hsd
1298090 rat Bp155 Blood pressure QTL 155 5 3.8 58.5 34206 D5Mgh15 34168 D5Mgh22 11002 D5Mit15 Blood pressure mean arterial systolic, diastolic and mean blood pressure recorded during carotid arterial cannulation using a pressure transducer increased systemic arterial blood pressure Hypertension 731210 14678232 3193 Nppa 5 157584492 167844579 1 - by flanking markers 5 157594531 167854767 1 - by flanking markers 728194;734760 SHR/N;WKY/Gcrc
1298524 rat Oia8 Oil induced arthritis QTL 8 4 34174 D4Mgh7 33778 D4Mit21 34473 D4Mgh10 Joint/bone inflammation oil induced arthritis severity after adjuvant injection was measured via a cumulative scoring system for multiple joints; animals were evaluated twice a week for six weeks joint inflammation Arthritis, Rheumatoid 629560 12571866 Oia2 4 136668162 181668162 3 - by peak only 4 158870655 159955541 2 - by one flank and peak markers 737861 DA.PVG.1AV1-(D4Rat63-D4Rat203)
1298525 rat Cm1 Cardiac mass QTL 1 7 2.7 62494 D7Uia1 66593 D7Mco1 Cardiac mass heart weight was measured in rats fed a diet containing 8% NaCl and was adjusted for increased heart weight Hypertension;Cardiomegaly 69710 9383281 Bp61 7 105412922 108875615 1 - by flanking markers 7 105447152 108909845 1 - by flanking markers 10040;10041 SR/Jr;SS/Jr
1298526 rat Arunc3 Aerobic running capacity QTL 3 3 2.2 35981 D3Rat56 38346 D3Rat98 35981 D3Rat56 Aerobic running capacity genome-wide scan of male animals after testing for maximal endurance capacity on a ramped treadmill at a constant slope of 15 degrees; starting velocity of 10 m/min was increased by 1m/min every 2 minutes; rats were run until exhausted increased aerobic running capacity;decreased aerobic running capacity 1547852;619535 16033863;12079278 735225;1305546;1309048;1311721 Serping1;Anapc2;Snapc4;Nmi dominant Arc2 3 3577905 30254280 1 - by flanking markers 3 3577811 30150507 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd
1298527 rat Arunc2 Aerobic running capacity QTL 2 16 2.9 37174 D16Rat42 36608 D16Rat48 41324 D16Rat55 Aerobic running capacity genome-wide scan of male animals after testing for maximal endurance capacity on a ramped treadmill at a constant slope of 15 degrees; starting velocity of 10 m/min was increased by 1m/min every 2 minutes; rats were run until exhausted increased aerobic running capacity;decreased aerobic running capacity 1547852;619535 16033863;12079278 2015;69316;620427;628670;1306769 Acsl1;Irs2;Pdlim3;Ppif;Tm2d2 dominant Arc3;Arc2 16 73394189 79850195 2 - by one flank and peak markers 16 73394454 79850460 2 - by one flank and peak markers 10011;734475 COP/OlaHsd;DA/OlaHsd
1298528 rat Bp169 Blood pressure QTL 169 7 1.0E-4 66604 D7Mco7 39956 D7Rat131 Blood pressure salt-loaded systolic systolic blood pressure was measured by tail-cuff method in rats fed a diet containing 2% NaCl decreased systemic arterial systolic blood pressure Hypotension 69711 11247666 Bp61 7 66882577 111882577 4 - by one flank marker only 7 111916807 113048241 1 - by flanking markers 1299868 SS.SR-(D7Uia1-D7Mco7)/Jr
1298529 rat Arunc1 Aerobic running capacity QTL 1 16 4.0 35280 D16Rat19 39838 D16Rat109 37054 D16Rat17 Aerobic running capacity genome-wide scan of male animals after testing for maximal endurance capacity on a ramped treadmill at a constant slope of 15 degrees; starting velocity of 10 m/min was increased by 1m/min every 2 minutes; rats were run until exhausted increased aerobic running capacity;decreased aerobic running capacity 1547852;619535 16033863;12079278 2015;2061;3199;69316;620427;628670;1306769 Acsl1;Adrb3;Npy5r;Irs2;Pdlim3;Ppif;Tm2d2 dominant Arc2 16 35339929 63977788 1 - by flanking markers 16 35340004 63977863 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
1298065 rat Scl16 Serum cholesterol level QTL 16 8 3.8 7.0 41026 D8Rat153 Lipid level cholesterol plasma cholesterol, HDL-cholesterol, and total triglyceride were determined on euthanized animals following 16 hours fasting increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2016 Acat1 8 33897608 78897608 3 - by peak only 8 33916662 78916662 3 - by peak only 634365;634366 SS/Hsd;SR/Hsd
1298066 rat Bp159 Blood pressure QTL 159 13 0.004 3804 Syt2 61281 D13M1Mit108 Blood pressure salt-loaded systolic systolic blood pressure was measured by tail-cuff method in male rats fed a diet containing 2% NaCl for 24 days decreased systemic arterial blood pressure;increased systemic arterial blood pressure;increased systemic arterial blood pressure Hypertension;Hypertension 61047;61040 9271663;9685318 Bp25 13 47690518 92690518 4 - by one flank marker only 13 47704560 92704560 4 - by one flank marker only 737864 SS.SR-(D13Mit9-D13Mit1)/Jr
1298067 rat Scl15 Serum cholesterol level QTL 15 5 4.8 0.001 10.0 33678 D5Mit10 Lipid level cholesterol plasma cholesterol, HDL-cholesterol, and total triglyceride were determined on euthanized animals following 16 hours fasting increased circulating cholesterol level Hypercholesterolemia 737694 14739155 5 35474610 80474610 3 - by peak only 5 35474789 80474789 3 - by peak only 634365;634366 SS/Hsd;SR/Hsd
1298068 rat Bp167 Blood pressure QTL 167 3 0.004 2534 Edn3 Blood pressure systolic measured using the tail-cuff method; relative heart weight also determined by measuring heart weight and body weight increased systemic arterial blood pressure Hypertension 61042 7963489 2534 Edn3 Bp15 3 144002709 171063335 3 - by peak only 10040;10041 SR/Jr;SS/Jr
1298069 rat Bp168 Blood pressure QTL 168 10 5.5 33632 D10Mit10 66563 D10Mco6 44786 D10Wox6 Blood pressure salt-loaded systolic measured by tail cuff method in rats fed a diet containing 8% NaCl increased systemic arterial blood pressure Hypertension 61040 9685318 3185 Nos2 Bp12 10 27184741 102587587 1 - by flanking markers 10 27185630 102601957 1 - by flanking markers 10041;60999 SS/Jr;LEW
1298070 rat Scl18 Serum cholesterol level QTL 18 5 3.7 7.0 35074 D5Rat23 Lipid level LDL cholesterol plasma cholesterol, HDL-cholesterol, and total triglyceride were determined on euthanized animals following 16 hours fasting increased circulating LDL cholesterol level Hypercholesterolemia 737694 14739155 728889 Adfp 5 84392127 129392127 3 - by peak only 5 84397353 129397353 3 - by peak only 634365;634366 SS/Hsd;SR/Hsd
1298071 rat Edpm12 Estrogen-dependent pituitary mass QTL 12 X 3.2 36301 DXRat9 Gland mass pituitary pituitaries weighed 70 days after rats given subcutaneous implants containing crystalline diethylstilbestrol (DES) pituitary gland hyperplasia Pituitary Neoplasms 629550 11003699 X 23620000 68620000 3 - by peak only X 23673453 68673453 3 - by peak only 10008;61109 BN/SsNHsd;F344/NHsd backcross
1298072 rat Cia26 Collagen induced arthritis QTL 26 18 3.6 33814 D18Mit9 37488 D18Rat60 33814 D18Mit9 Joint/bone inflammation type II collagen induced joint swelling Arthritis, Rheumatoid 2307198;2300074;1582387;1285224 18540828;18606636;16804090;15334486 recessive 18 57870442 87265094 3 - by peak only 18 57943956 87338544 3 - by peak only 10000;631182;737892 ACI/N;DA/BklArbN;ACI/SegHsd intercross
1298073 rat Cm13 Cardiac mass QTL 13 3 2.5 37510 D3Rat100 66449 D3Mco16 60801 D3Wox3 Cardiac mass heart weight measured in rats fed a diet containing 8% NaCl and normalized for population and gender differences increased heart weight;increased systemic arterial blood pressure Hypertension 69705 9922389 Bp52 3 21201203 35237920 1 - by flanking markers 3 21097575 35134293 1 - by flanking markers 10040;10041 SR/Jr;SS/Jr
1298074 rat Bp164 Blood pressure QTL 164 2 0.003 37018 D2Rat14 34461 D2Mgh12 Blood pressure salt-loaded systolic measured in congenic strain SHRSP.WKY-(D2Rat14-D2Mgh12) and compared to parental strain SHRSP increased systemic arterial blood pressure Hypertension 728179 11980293 Bp13;Bp165 2 165636169 210636169 4 - by one flank marker only 2 165598923 210598923 4 - by one flank marker only 731191 SHRSP.WKY-(D2Rat14-D2Mgh12)/Gcrc
1298075 rat Scl17 Serum cholesterol level QTL 17 2 3.4 7.0 34864 D2Rat67 Lipid level cholesterol plasma cholesterol, HDL-cholesterol, and total triglyceride were determined on euthanized animals following 16 hours fasting increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2 221002002 258207540 3 - by peak only 2 220988742 258222147 3 - by peak only 634365;634366 SS/Hsd;SR/Hsd
1298076 rat Bp166 Blood pressure QTL 166 2 9.0E-4 60798 D2Wox9 34461 D2Mgh12 Blood pressure systolic systolic and diastolic blood pressure were measured in a congenic strain SHRSP.WKY-(D2Wox9-D2Mgh12) and compared to blood pressure of the parental strain SHRSP increased systemic arterial blood pressure Hypertension 728179 11980293 2756 Gstm2 Bp14 2 165636169 210636169 4 - by one flank marker only 2 165598923 210598923 4 - by one flank marker only 737863 SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc
1298077 rat Bp157 Blood pressure QTL 157 5 36667 D5Rat54 62518 D5Uia8 Blood pressure salt-loaded systolic blood pressure measured on by tail-cuff method on rats fed a diet contining 2%NaCl decreased systemic arterial blood pressure;increased systemic arterial blood pressure Hypertension 1643012;619649 17938377;11875185 3170 Nfia Bp7 5 121964552 126386030 1 - by flanking markers 5 121969778 126391257 1 - by flanking markers 629578;728135;728145;728156;728157 SS.LEW-(D5Rat130-D5Mco10)/Jr;SS.LEW-(D5Uwm14-D5Uwm31)/Jr;SS.LEW-(D5Rat130-D5Rat108)/Jr;SS.LEW-(D5Mco34-D5Mco10)/Jr;SS.LEW-(D5Rat130-D5Mco19)/Jr
1298078 rat Stresp5 Stress response QTL 5 10 2.99 2.5E-4 9.0 41394 D10Rat164 41584 D10Rat135 35256 D10Rat11 Hormone level corticosterone late afternoon blood samples obtained from male rats and assayed for corticosterone levels; multiple steps were taken to minimize stress in the animals increased circulating corticosterone level 737981 15013833 10 43458380 108776963 1 - by flanking markers 10 43472004 108791662 1 - by flanking markers 61109;1298093 F344/NHsd;LEW/NHsd
1298079 rat Activ2 Activity QTL 2 8 9.5 1.0E-6 29.0 33858 D8Mit4 10169 D8Wox11 Activity level novel environment activity measured in activity cages at 10 min, 60 min and 24 hour time intervals; open-field test and elevated-plus maze test also performed; endocrine levels were measured increased exploration in new environment Hyperkinesis 631228 12660808 62388 Htr5b Act1 8 44484215 89484215 4 - by one flank marker only 8 30560823 75560823 4 - by one flank marker only 61103;68186 WKY;WKHA/N
1302404 rat Cia27 Collagen induced arthritis QTL 27 10 10642 D10Mit12 34128 D10Mgh1 44839 D10Wox7 Joint/bone inflammation type II collagen induced new arthritis severity and susceptibility QTL. joint swelling;joint inflammation Arthritis, Rheumatoid 2307198;61063;1600534 18540828;9870869;16691185 10 95695048 110718848 2 - by one flank and peak markers 10 81065351 110733352 3 - by peak only 1302416 ACI.DA-(D10Rat2-D10Rat19)
1302786 rat Kidm8 Kidney mass QTL 8 5 28.15 33678 D5Mit10 Kidney mass kidney wet weight and plasma urea concentration were determined in (PKDxWOK)F1xWOK backcross rats sacrificed at 2 months of age, polycystic kidney disease status was assigned by histological analysis of kidney tissue in which animals were considered to be affected if cysts up to the diameter of two glomeruli were observed in several visual fields increased blood urea nitrogen level;enlarged kidney Polycystic Kidney Diseases;Uremia 629573 9097967 3334 Anks6 dominant 5 35474610 80474610 3 - by peak only 5 35474789 80474789 3 - by peak only 68118;728168 PKD;WOK
1302787 rat Tgl10 Triglyceride level QTL 10 1 2.7 0.0073 36592 D1Rat64 36757 D1Rat71 Lipid level triglyceride rats were fitted with carotid artery and jugular vein catheters, and measured at 5-6 months of age for plasma triglycerides, total cholesterol, blood pressures, and body weight increased circulating cholesterol level;increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 1 184857716 216663271 1 - by flanking markers 1 185007598 216821585 1 - by flanking markers 60999;1302795 LEW;HTG intercross
1302788 rat Scl19 Serum cholesterol QTL 19 1 4.6 0.001 38792 D1Rat137 36432 D1Rat35 36765 D1Rat27 Lipid level cholesterol rats were fitted with carotid artery and jugular vein catheters, and measured at 5-6 months of age for plasma triglycerides, total cholesterol, blood pressures, and body weight increased circulating cholesterol level Hypercholesterolemia 1299960 14709677 1 90306033 124749065 1 - by flanking markers 1 90384146 124827408 1 - by flanking markers 60999;1302795 LEW;HTG intercross
1302789 rat Tgl8 Triglyceride level QTL 8 2 3.1 0.0035 35693 D2Rat55 37424 D2Rat111 35915 D2Rat61 Lipid level triglyceride rats were fitted with carotid artery and jugular vein catheters, and measured at 5-6 months of age for plasma triglycerides, total cholesterol, blood pressures, and body weight increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 2 212168913 242131385 2 - by one flank and peak markers 2 212131668 242141990 2 - by one flank and peak markers 60999;1302795 LEW;HTG intercross
1302790 rat Scl20 Serum cholesterol QTL 20 5 6.4 1.0E-4 41318 D5Rat147 36237 D5Rat49 38338 D5Rat108 Lipid level cholesterol rats were fitted with carotid artery and jugular vein catheters, and measured at 5-6 months of age for plasma triglycerides, total cholesterol, blood pressures, and body weight decreased circulating cholesterol level 1299960 14709677 5 86116638 172913795 1 - by flanking markers 5 86121751 172924290 1 - by flanking markers 60999;1302795 LEW;HTG intercross
1302791 rat Tgl9 Triglyceride level QTL 9 13 3.3 0.0011 45079 D13Wox8 33644 D13Mit4 37088 D13Rat34 Lipid level triglyceride rats were fitted with carotid artery and jugular vein catheters, and measured at 5-6 months of age for plasma triglycerides, total cholesterol, blood pressures, and body weight increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 13 88260176 90551272 1 - by flanking markers 13 88449060 90740156 1 - by flanking markers 60999;1302795 LEW;HTG
1302792 rat Scl21 Serum cholesterol QTL 21 12 3.8 0.0011 35923 D12Rat12 38952 D12Rat40 34898 D12Rat20 Lipid level cholesterol rats were fitted with carotid artery and jugular vein catheters, and measured at 5-6 months of age for plasma triglycerides, total cholesterol, blood pressures, and body weight decreased circulating cholesterol level 1299960 14709677 12 7754826 25802539 1 - by flanking markers 12 7784630 25665800 1 - by flanking markers 60999;1302795 LEW;HTG
1302793 rat Bw16 Body weight QTL 16 2 5.0 1.0E-4 35921 D7Rat12 34234 D2Mgh9 Body weight increased body weight Metabolic Syndrome X;Obesity 1299960 14709677 2 146378271 191378271 4 - by one flank marker only 2 146341025 191341025 4 - by one flank marker only 60999;1302795 LEW;HTG intercross
1302794 rat Tgl7 Triglyceride level QTL 7 2 4.4 1.0E-4 38576 D2Rat182 34005 D2Mit8 39512 D2Rat210 Lipid level triglyceride rats were fitted with carotid artery and jugular vein catheters, and measured at 5-6 months of age for plasma triglycerides, total cholesterol, blood pressures, and body weight increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 2 24474447 148790758 1 - by flanking markers 2 24394817 148740721 1 - by flanking markers 60999;1302795 LEW;HTG intercross
1300123 rat Bp194 Blood pressure QTL 194 17 2.82 35116 D17Rat53 35697 D17Rat16 38348 D17Rat59 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 17 7696509 41028541 1 - by flanking markers 17 7696509 41031382 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300124 rat Cm4 Cardiac mass QTL 4 9 3.55 38604 D9Rat101 35819 D9Rat26 40170 D9Rat135 Cardiac mass salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal plasma flow rate;abnormal heart size;increased systemic arterial blood pressure Cardiomegaly;Hypertension 727992 14532335 9 1 37313370 2 - by one flank and peak markers 9 3687583 37314694 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300125 rat Rf26 Renal function QTL 26 18 3.2 34182 D18Mgh3 37568 D18Rat55 39610 D18Rat91 Renal function salt-loaded potassium excretion 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way decreased potassium excretion Kidney Diseases 727992 14532335 18 54856651 69013303 1 - by flanking markers 18 54928883 69086504 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300126 rat Bp175 Blood pressure QTL 175 2 3.46 35290 D2Rat60 36241 D2Rat72 34858 D2Rat69 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way kidney inflammation;increased systemic arterial blood pressure Hypertension 727992 14532335 Bp174 2 222939299 256217383 1 - by flanking markers 2 222925979 256231990 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300127 rat Srn1 Serum renin concentration QTL 1 7 3.49 34880 D7Rat31 41186 D7Rat139 38794 D7Rat73 Renin concentration salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renin activity Kidney Diseases 727992 14532335 7 28488298 89945095 1 - by flanking markers 7 28508773 89979325 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300128 rat Rf16 Renal function QTL 16 6 3.89 35963 D6Rat46 35396 D6Rat35 39124 D6Rat62 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way decreased renal plasma flow rate;abnormal renal plasma flow rate Kidney Diseases 727992 14532335 6 13286615 35233017 1 - by flanking markers 6 13286615 35235970 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300129 rat Rf25 Renal function QTL 25 17 3.03 35274 D17Rat45 35827 D17Rat52 35687 D17Rat47 Renal function salt-loaded creatinine clearance 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way decreased creatinine clearance;abnormal kidney clearance;abnormal circulating creatinine level Kidney Diseases 727992 14532335 17 82277326 92594341 1 - by flanking markers 17 82288264 92605174 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300130 rat Rf20 Renal function QTL 20 11 4.44 35483 D11Rat15 35955 D11Rat38 40546 D11Rat71 Renal function hypertension related glomerular damage 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal renal glomerulus morphology;kidney inflammation Hypertension;Kidney Diseases 727992 14532335 11 29744366 62045696 1 - by flanking markers 11 29744438 62103285 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300131 rat Bp193 Blood pressure QTL 193 17 3.3 35258 D17Rat36 35687 D17Rat47 35274 D17Rat45 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 17 74663818 85072475 1 - by flanking markers 17 74674651 85083308 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300132 rat Bp182 Blood pressure QTL 182 7 3.87 36691 D7Rat27 41186 D7Rat139 38794 D7Rat73 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp181 7 32004504 89945095 1 - by flanking markers 7 32024776 89979325 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300133 rat Rf24 Renal function QTL 24 16 3.64 40724 D16Rat87 39586 D16Rat76 40724 D16Rat87 Renal function salt-loaded creatinine clearance 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal circulating creatinine level;abnormal kidney clearance Hypertension 727992 14532335 16 3464719 22979073 1 - by flanking markers 16 3465041 22979071 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300134 rat Bp185 Blood pressure QTL 185 9 3.73 34815 D9Rat16 39380 D9Rat108 36908 D9Rat4 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 9 58516719 103918256 1 - by flanking markers 9 58663702 104127736 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300135 rat Rf19 Renal function QTL 19 11 3.38 40546 D11Rat71 10375 D11Mgh1 36065 D11Rat6 Renal function salt-loaded creatinine clearance 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal kidney clearance;decreased protein excretion;increased systemic arterial blood pressure;abnormal circulating creatinine level Hypertension;Proteinuria 727992 14532335 11 41711171 84560241 1 - by flanking markers 11 41768538 84600838 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300136 rat Rf22 Renal function QTL 22 14 3.9 35319 D14Rat16 40140 D14Rat95 40852 D14Rat90 Renal function salt-loaded renal vascular resistance 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased renal vascular resistance;abnormal renal plasma flow rate Kidney Diseases;Hypertension, Renal 727992 14532335 14 44934410 101647208 1 - by flanking markers 14 44992308 101666284 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300137 rat Bp186 Blood pressure QTL 186 10 3.57 34896 D10Rat17 35254 D10Rat2 35254 D10Rat2 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 10 95066219 110718848 4 - by one flank marker only 10 95080680 110733352 4 - by one flank marker only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300138 rat Hrtrt9 Heart rate QTL 9 7 4.72 36691 D7Rat27 38794 D7Rat73 42215 D7Arb16 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal kidney excretion;increased systemic arterial blood pressure;abnormal heart rate Hypertension 727992 14532335 7 32004504 57326584 1 - by flanking markers 7 32024776 57347162 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300139 rat Hrtrt6 Heart rate QTL 6 4 2.85 34238 D4Mgh2 38344 D4Rat106 41200 D4Rat169 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal heart rate;increased heart rate Heart Diseases 727992 14532335 Hr5 4 36611842 117887968 1 - by flanking markers 4 36730383 118132317 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300140 rat Srn3 Serum renin concentration QTL 3 14 3.19 35965 D14Rat6 34965 D14Rat10 36520 D14Rat7 Renin concentration salt-loaded 10-week old rats were given a low-salt diet, fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renin activity Kidney Diseases 727992 14532335 14 16432517 33157602 1 - by flanking markers 14 16432792 33157602 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300141 rat Bp178 Blood pressure QTL 178 4 36504 D4Rat2 34238 D4Mgh2 38908 D4Rat126 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp179 4 5437007 36612108 1 - by flanking markers 4 5437007 36730648 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300142 rat Bp191 Blood pressure QTL 191 15 3.14 40434 D15Rat114 38696 D15Rat75 40434 D15Rat114 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 15 1 14324156 4 - by one flank marker only 15 0 14324156 4 - by one flank marker only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300143 rat Rf14 Renal function QTL 14 6 2.92 35396 D6Rat35 41416 D6Rat126 36586 D6Rat26 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way abnormal renal plasma flow rate;decreased creatinine clearance Kidney Diseases 727992 14532335 6 35232849 80102311 1 - by flanking markers 6 35235803 80105877 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300144 rat Rf23 Renal function QTL 23 15 3.61 34910 D15Rat14 40516 D15Rat106 34409 D15Mgh9 Renal function salt-loaded renal vascular resistance 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased renal vascular resistance;abnormal renal plasma flow rate Kidney Diseases;Hypertension, Renal 727992 14532335 15 45870097 106177917 1 - by flanking markers 15 45885878 106193697 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300145 rat Rf7 Renal function QTL 7 1 2.96 37556 D1Rat130 35909 D1Rat74 40230 D1Rat295 Renal function salt-loaded urine creatinine concentration 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way decreased creatinine clearance;abnormal kidney clearance Kidney Diseases 727992 14532335 Rf6;Rf8 1 189900686 227005733 1 - by flanking markers 1 190050568 227169515 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300146 rat Rf17 Renal function QTL 17 8 2.9 35663 D8Rat51 41122 D8Rat159 36673 D8Rat49 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way decreased renal plasma flow rate;abnormal renal plasma flow rate Kidney Diseases 727992 14532335 8 29559446 74559446 4 - by one flank marker only 8 29565716 74565716 4 - by one flank marker only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300147 rat Bp187 Blood pressure QTL 187 11 3.67 35957 D11Rat22 41256 D11Rat61 35483 D11Rat15 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 11 9053659 50435443 2 - by one flank and peak markers 11 9053659 50435385 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300148 rat Bp192 Blood pressure QTL 192 17 3.47 35697 D17Rat16 35687 D17Rat47 35258 D17Rat36 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 17 41028379 85072475 1 - by flanking markers 17 41031221 85083308 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300149 rat Cm6 Cardiac mass QTL 6 7 4.09 41130 D7Rat136 42215 D7Arb16 35068 D7Rat32 Cardiac mass salt-loaded left ventricle 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal heart size;abnormal heart ventricle morphology;abnormal hematocrit;abnormal leukocyte cell number Cardiomegaly 727992 14532335 7 47145774 107950815 1 - by flanking markers 7 47166045 107984993 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300150 rat Cm3 Cardiac mass QTL 3 8 3.97 41454 D8Rat149 36161 D8Rat36 41122 D8Rat159 Cardiac mass salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal heart size Cardiomegaly 727992 14532335 8 57308742 58692901 1 - by flanking markers 8 57327796 58711961 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300151 rat Bp181 Blood pressure QTL 181 7 3.36 38794 D7Rat73 40966 D7Rat133 41186 D7Rat139 Blood pressure salt-loaded diastolic 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 7 57326196 109727159 1 - by flanking markers 7 57346927 109761389 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300152 rat Bp195 Blood pressure QTL 195 20 3.46 34749 D20UW1 34908 D20Rat2 34749 D20UW1 Blood pressure salt-loaded systolic 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 20 3660638 9534510 1 - by flanking markers 20 3660865 9534723 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300153 rat Bp171 Blood pressure QTL 171 1 3.37 41374 D1Rat265 37970 D1Rat210 37930 D1Rat183 Blood pressure salt-loaded diastolic 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp170;Bp172;Bp173 1 90448902 145865373 1 - by flanking markers 1 90527111 145943779 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300154 rat Bp189 Blood pressure QTL 189 14 3.04 34965 D14Rat10 40852 D14Rat90 36287 D14Rat12 Blood pressure salt-loaded diastolic 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 14 33157432 73956701 1 - by flanking markers 14 33157433 73959092 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300155 rat Bp174 Blood pressure QTL 174 2 4.09 37018 D2Rat14 41400 D2Rat216 40672 D2Rat202 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal kidney excretion;increased systemic arterial blood pressure Hypertension;Proteinuria 727992 14532335 Bp175 2 29321080 74321080 3 - by peak only 2 29249313 74249313 3 - by peak only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300156 rat Bp179 Blood pressure QTL 179 4 2.85 35847 D4Rat12 34238 D4Mgh2 38908 D4Rat126 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp178 4 15744638 36612108 2 - by one flank and peak markers 4 15657894 36730648 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300157 rat Rf21 Renal function QTL 21 12 4.42 35501 D12Rat2 37830 D12Rat36 34729 D12Mgh5 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way decreased renal plasma flow rate Hypertension;Kidney Diseases 727992 14532335 12 9628802 33216334 1 - by flanking markers 12 9658731 33079722 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300158 rat Bp173 Blood pressure QTL 173 1 3.48 35166 D1Rat33 37556 D1Rat130 38878 D1Rat139 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp170;Bp171;Bp172 1 148481548 189900838 2 - by one flank and peak markers 1 116231455 190050719 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300159 rat Kidm4 Kidney mass QTL 4 3 3.83 36717 D3Rat17 40676 D3Rat142 36584 D3Rat6 Kidney mass hypertension related 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way abnormal kidney size;increased systemic arterial blood pressure;abnormal renal plasma flow rate Hypertension 727992 14532335 Rf10;Rf11;Rf12 3 121618954 159769019 1 - by flanking markers 3 121524528 159675055 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300160 rat Hrtrt3 Heart rate QTL 3 2 3.62 40242 D2Rat194 40672 D2Rat202 37018 D2Rat14 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal heart rate;increased heart rate Hypertension;Heart Diseases 727992 14532335 2 29237360 51821161 1 - by flanking markers 2 29157564 51749394 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300161 rat Rf10 Renal function QTL 10 3 3.57 41322 D3Rat137 38456 D3Rat77 36797 D3Rat11 Renal function hypertension related renal vascular resistance 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal renal plasma flow rate Hypertension 727992 14532335 Rf11;Rf12;Rf13 3 101298208 163335184 2 - by one flank and peak markers 3 163241044 167072217 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300162 rat Bp188 Blood pressure QTL 188 12 3.19 37830 D12Rat36 35431 D12Rat22 35431 D12Rat22 Blood pressure salt-loaded systolic 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 12 33216127 46043557 1 - by flanking markers 12 33079515 45907684 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300163 rat Cardf1 Cardiac cell morphology QTL 1 13 4.18 36922 D13Rat4 38240 D13Rat91 36922 D13Rat4 Cardiac function salt-loaded aortic lesions 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal aorta morphology Cardiomegaly 727992;70849 14532335;11721057 13 1265159 46912163 1 - by flanking markers 13 1265159 46926206 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300164 rat Rf15 Renal function QTL 15 6 35963 D6Rat46 36586 D6Rat26 35653 D6Rat42 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal renal plasma flow rate Hypertension 727992 14532335 6 13286615 56714969 1 - by flanking markers 6 13286615 56717980 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300165 rat Rf9 Renal function QTL 9 2 3.28 37456 D2Rat147 34461 D2Mgh12 36213 D2Rat40 Renal function hypertension related glomerular damage 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way abnormal renal glomerulus morphology;kidney inflammation;increased systemic arterial blood pressure Kidney Diseases;Hypertension 727992 14532335 2 138700979 210636169 1 - by flanking markers 2 138650942 210598923 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300166 rat Kidm6 Kidney mass QTL 6 13 3.93 37844 D13Rat85 33644 D13Mit4 33644 D13Mit4 Kidney mass salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal kidney weight Kidney Diseases 727992 14532335 13 72141292 90551272 1 - by flanking markers 13 72155481 90740156 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300167 rat Hrtrt2 Heart rate QTL 2 1 4.35 36568 D1Rat4 34037 D1Mit1 38782 D1Rat136 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal heart rate;increased heart rate Heart Diseases 727992 14532335 Hr1 1 11859997 63434427 2 - by one flank and peak markers 1 11860049 56718312 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300168 rat Bp170 Blood pressure QTL 170 1 2.76 40230 D1Rat295 40028 D1Rat301 35909 D1Rat74 Blood pressure salt-loaded mean arterial 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp171;Bp172;Bp173 1 213554130 234595366 1 - by flanking markers 1 213712561 234759389 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300169 rat Bp177 Blood pressure QTL 177 3 2.96 38346 D3Rat98 39912 D3Rat180 41780 D3Rat227 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp176 3 30253942 58764827 1 - by flanking markers 3 30150317 58661199 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300170 rat Rf6 Renal function QTL 6 1 3.14 37610 D1Rat167 36568 D1Rat4 37610 D1Rat167 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way decreased renal plasma flow rate;abnormal renal plasma flow rate Kidney Diseases 727992 14532335 Rf7 1 4404877 11860328 1 - by flanking markers 1 4404878 11860218 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300171 rat Bp184 Blood pressure QTL 184 8 3.66 38670 D8Rat114 36327 D8Rat2 34180 D8Mgh1 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 8 74281610 123415406 1 - by flanking markers 8 74300664 123435143 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300172 rat Bp172 Blood pressure QTL 172 1 3.56 37598 D1Rat176 41374 D1Rat265 34037 D1Mit1 Blood pressure salt-loaded diastolic 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Bp170;Bp171;Bp173 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300173 rat Rf11 Renal function QTL 11 3 3.38 36717 D3Rat17 36584 D3Rat6 36797 D3Rat11 Renal function hypertension related renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal renal plasma flow rate Hypertension 727992 14532335 Rf10;Rf12;Rf13 3 121618954 147990731 1 - by flanking markers 3 121524528 147896729 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300174 rat Bw15 Body weight QTL 15 12 2.93 40394 D12Rat89 35501 D12Rat2 40394 D12Rat89 Body weight salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal body weight 727992 14532335 12 2957061 9628971 1 - by flanking markers 12 2957061 9658899 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300175 rat Cm5 Cardiac mass QTL 5 12 3.78 34729 D12Mgh5 35431 D12Rat22 37830 D12Rat36 Cardiac mass salt-loaded left ventricle 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal plasma flow rate;abnormal heart size;increased systemic arterial blood pressure Cardiomegaly 727992 14532335 12 29130180 46043557 1 - by flanking markers 12 28993569 45907684 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300176 rat Hrtrt10 Heart rate QTL 10 7 3.19 35382 D7Rat36 34880 D7Rat31 35382 D7Rat36 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal heart rate Hypertension 727992 14532335 7 1526177 28488710 1 - by flanking markers 7 1525941 28508913 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300177 rat Cm2 Cardiac mass QTL 2 8 3.65 41122 D8Rat159 36003 D8Rat14 36809 D8Rat23 Cardiac mass salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal heart rate;abnormal heart size Cardiomegaly;Hypertension 727992 14532335 8 59697495 104697495 4 - by one flank marker only 8 59716950 104716950 4 - by one flank marker only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300178 rat Hrtrt4 Heart rate QTL 4 3 3.74 41780 D3Rat227 40016 D3Rat168 39912 D3Rat180 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal heart rate;increased heart rate Heart Diseases 727992 14532335 3 41054012 89859652 1 - by flanking markers 3 40950385 89756143 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300179 rat Kidm5 Kidney mass QTL 5 7 3.51 42215 D7Arb16 35559 D7Rat13 41186 D7Rat139 Kidney mass salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal kidney weight Kidney Diseases 727992 14532335 7 47145687 124315164 1 - by flanking markers 7 47165959 124349394 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300180 rat Bw14 Body weight QTL 14 9 3.776 40738 D9Rat130 34815 D9Rat16 35819 D9Rat26 Body weight salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased body weight;abnormal body weight 727992 14532335 9 20102034 58516896 1 - by flanking markers 9 20099890 58663878 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300107 rat Rf18 Renal function QTL 18 10 3.4 39226 D10Rat86 40488 D10Rat201 34896 D10Rat17 Renal function salt-loaded urine volume 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way polyuria;abnormal kidney excretion Kidney Diseases;Polyuria 727992 14532335 10 82474813 102865929 1 - by flanking markers 10 82489184 102880299 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300108 rat Rf8 Renal function QTL 8 1 3.75 40028 D1Rat301 35457 D1Rat90 35457 D1Rat90 Renal function salt-loaded renal vascular resistance 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way decreased renal plasma flow rate;increased renal vascular resistance;abnormal renal plasma flow rate Kidney Diseases;Hypertension, Renal 727992 14532335 Rf6;Rf7 1 234595190 267111153 1 - by flanking markers 1 234759214 267322172 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300109 rat Rf13 Renal function QTL 13 4 3.91 35879 D4Rat67 36655 D4Rat70 39414 D4Rat204 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way abnormal renal plasma flow rate;increased systemic arterial blood pressure Hypertension 727992 14532335 4 161028989 184893756 1 - by flanking markers 4 161273925 185138880 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300110 rat Stl7 Serum triglyceride level QTL 7 11 4.64 35483 D11Rat15 10375 D11Mgh1 35955 D11Rat38 Lipid level salt-loaded triglyceride 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased circulating triglyceride level;abnormal circulating creatinine level;increased systemic arterial blood pressure Hypertriglyceridemia 727992 14532335 11 29744366 84560241 1 - by flanking markers 11 29744438 84600838 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300111 rat Rf12 Renal function QTL 12 3 3.78 39912 D3Rat180 36717 D3Rat17 39408 D3Rat169 Renal function salt-loaded renal blood flow 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to cardiac and renal function to be measured in a conscious unrestrained way abnormal renal glomerulus morphology;increased systemic arterial blood pressure;abnormal renal plasma flow rate;kidney inflammation Hypertension;Kidney Diseases 727992 14532335 Rf10;Rf11;Kw4 3 58764506 121619110 1 - by flanking markers 3 58660878 121524683 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300112 rat Bp183 Blood pressure QTL 183 7 3.51 35559 D7Rat13 37774 D7Rat80 37774 D7Rat80 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 7 124315012 141301748 1 - by flanking markers 7 124349243 141378185 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300113 rat Bp176 Blood pressure QTL 176 3 3.9 36584 D3Rat6 40676 D3Rat142 37980 D3Rat114 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;abnormal kidney size Hypertension 727992 14532335 Bp177 3 147990566 159769019 1 - by flanking markers 3 147896437 159675055 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300114 rat Srn2 Serum renin concentration QTL 2 14 3.27 36536 D14Rat1 41990 D14Arb16 35965 D14Rat6 Renin concentration salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renin activity Kidney Diseases 727992 14532335 14 4895894 22837299 1 - by flanking markers 14 4895895 22837299 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300115 rat Hrtrt7 Heart rate QTL 7 5 2.76 36279 D5Rat4 40992 D5Rat148 34216 D5Mgh6 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate;abnormal heart rate Heart Diseases 727992 14532335 Hr8;Bp180 5 49767270 93862300 2 - by one flank and peak markers 5 49767450 89254341 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300116 rat Hrtrt5 Heart rate QTL 5 4 3.76 38344 D4Rat106 41568 D4Rat200 34174 D4Mgh7 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal heart rate;increased heart rate Heart Diseases 727992 14532335 4 117887605 154283969 1 - by flanking markers 4 118132148 154528810 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300117 rat Hrtrt8 Heart rate QTL 8 5 3.49 39686 D5Rat119 36279 D5Rat4 36618 D5Rat2 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased circulating triglyceride level;abnormal heart rate;increased systemic arterial blood pressure Hypertriglyceridemia 727992 14532335 Hr7;Bp180 5 2965857 49767421 1 - by flanking markers 5 2965812 49767600 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300118 rat Bp190 Blood pressure QTL 190 15 2.94 34409 D15Mgh9 40516 D15Rat106 40516 D15Rat106 Blood pressure salt-loaded diastolic 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 15 89569706 106177917 1 - by flanking markers 15 89585486 106193697 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300119 rat Bp180 Blood pressure QTL 180 5 3.82 39176 D5Rat103 41798 D5Rat246 39168 D5Rat99 Blood pressure salt-loaded time series calculation 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 727992 14532335 Hr7;Hr8 5 151039725 164343989 2 - by one flank and peak markers 5 151049805 164353989 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300120 rat Kidm7 Kidney mass QTL 7 15 3.55 34409 D15Mgh9 40516 D15Rat106 35497 D15Rat25 Kidney mass salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal plasma flow rate;increased systemic arterial blood pressure;abnormal kidney weight Hypertension 727992 14532335 15 89569706 106177917 1 - by flanking markers 15 89585486 106193697 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300121 rat Hrtrt1 Heart rate QTL 1 1 3.7 34037 D1Mit1 35166 D1Rat33 41374 D1Rat265 Heart rate salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate;abnormal heart rate Heart Diseases 727992 14532335 Hr2 1 67949072 112949072 3 - by peak only 1 56717951 116231605 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300122 rat Wbc1 White blood cell count QTL 1 5 2.75 40992 D5Rat148 38510 D5Rat63 38828 D5Rat90 White blood cell count salt-loaded 10-week old rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal leukocyte cell number;increased leukocyte cell number Heart Diseases;Inflammation 727992 14532335 5 132262882 147065912 2 - by one flank and peak markers 5 89253932 147075951 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1300075 rat Glom7 Glomerulus QTL 7 6 5.6 2.0E-7 33987 D6Mit8 Renal function glomerulus number number of superficial glomeruli present in the renal cortex corticis zone but without direct surface contact counted in three mid-coronal sections for each animal increased surface glomeruli Kidney Diseases 730279 14638907 6 75061972 120061972 3 - by peak only 6 75065429 120065429 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub
1300076 rat Glom8 Glomerulus QTL 8 6 7.0 9.0E-9 36990 D6Rat12 Renal function glomerulus number measured by counting the number of surface glomeruli per section with direct contact to the surface increased surface glomeruli Kidney Diseases 730279 14638907 6 91532057 136532057 3 - by peak only 6 91535616 136535616 3 - by peak only 731185;731186 MWF/Fub;SHR/Fub
1331763 rat Wbc2 White blood cell count QTL 2 12 3.162 34246 D12Mgh3 34455 D12Mgh8 34729 D12Mgh5 White blood cell count 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased leukocyte cell number Inflammation;Heart Diseases 70849 11721057 Bp218;Bp219;Hr14 12 25271823 32988661 2 - by one flank and peak markers 12 25134969 32852291 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331764 rat Bp205 Blood pressure QTL 205 2 3.476 36145 D2Rat73 34278 D2Mgh14 34425 D2Mgh1 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp202;Bp203;Bp204;Bp206;Hr12;Cm29 2 26101088 42866342 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331765 rat Hrtrt15 Heart rate QTL 15 17 4.094 34276 D17Mgh2 36329 D17Rat32 35302 D17Rat9 Heart rate 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate;increased heart rate variability Hypertension;Cardiovascular Diseases 70849 11721057 Rf43 17 21286334 36519720 2 - by one flank and peak markers 17 21286334 36525186 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331766 rat Bp236 Blood pressure QTL 236 18 3.022 11461 D18Mit1 10689 D18Mit5 34340 D18Mgh7 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp237;Bp238 18 80277473 87265094 4 - by one flank marker only 18 12433620 32494206 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331767 rat Hrtrt12 Heart rate QTL 12 2 3.373 34495 D2Mgh29 34505 D2Mgh16 33763 D2Mit15 Heart rate 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate Heart Diseases 70849 11721057 Bp202;Bp203;Bp204;Bp205;Bp206;Cm29 2 227309864 250463887 1 - by flanking markers 2 227296545 250478494 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331768 rat Kidm10 Kidney mass QTL 10 7 4.62096 33648 D7Mit5 33729 D7Mit10 33557 D7Mit14 Kidney mass left kidney mass 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way enlarged kidney Kidney Diseases 70849 11721057 Km9;Bw25 7 85089895 140651095 2 - by one flank and peak markers 7 85110626 140698824 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331775 rat Bp235 Blood pressure QTL 235 18 3.201 34092 D18Mgh8 10689 D18Mit5 34550 D18Mgh9 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp236;Bp237;Bp238 18 15852436 35389472 2 - by one flank and peak markers 18 15879082 32494206 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331776 rat Bp225 Blood pressure QTL 225 18 2.829 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 Blood pressure diastolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial diastolic blood pressure Hypertension 70849 11721057 Bp236;Bp237;Bp238;Bp224;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235 18 32105822 77105822 3 - by peak only 18 32494084 62302324 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331777 rat Bw24 Body weight QTL 24 3 3.503 34336 D3Mgh7 35380 D3Rat27 34146 D3Mgh6 Body weight increased body weight Obesity 70849 11721057 3 36556706 87981257 1 - by flanking markers 3 36453079 87877685 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331778 rat Rf28 Renal function QTL 28 1 4.66 34433 D1Mgh3 10337 D1Mgh5 33931 D1Mit10 Renal function potassium excretion rate 10-week old male rats from the F2 generation were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased potassium excretion Kidney Diseases 70849 11721057 Rf29;Srn4;Rf27 1 33134446 78134446 4 - by one flank marker only 1 33212557 78212557 4 - by one flank marker only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331769 rat Rf39 Renal function QTL 39 8 3.871 33858 D8Mit4 11225 D8Mgh15 33957 D8Mit16 Renal function urine volume 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way polyuria Kidney Diseases 70849 11721057 Cm30 8 44484215 103672447 1 - by flanking markers 8 30560823 103691902 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331770 rat Bp234 Blood pressure QTL 234 18 3.807 33884 D18Mit8 36123 D18Rat9 34182 D18Mgh3 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp235;Bp236;Bp237;Bp238 18 65125459 72901291 2 - by one flank and peak markers 18 62301978 75871174 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331771 rat Rf35 Renal function QTL 35 5 4.36965 34226 D5Mgh1 36558 D5Rat19 34212 D5Mgh5 Renal function renal blood flow 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Rf32;Rf33;Rf34;Rf36;Scl26 5 378448 90620456 2 - by one flank and peak markers 5 373693 90625569 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331772 rat Cdexp2 CD45RC expression in CD8 T cells QTL 2 20 5.7 22.5 34749 D20UW1 37872 D20Rat31 37594 D20Rat41 CD8 T cell CD45RC expression level CD8 T cells were negatively selected from lymph node and spleen cells. Using flow cytometry, CD45RC(low) and CD45RC(high) CD8 T-cell subpopulations were quantitated. abnormal CD8-positive T cell morphology Autoimmune Diseases 1302824 15322174 additive 20 3660638 10410227 1 - by flanking markers 20 3660865 10410454 1 - by flanking markers 631593;631594 LEW/Rj;BN/Rj
1331773 rat Scl26 Serum cholesterol QTL 26 5 3.065 34212 D5Mgh5 36558 D5Rat19 34419 D5Mgh25 Lipid level cholesterol 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased circulating cholesterol level Hyperlipidemia 70849 11721057 Rf32;Rf33;Rf34;Rf35;Rf36 5 45499364 90620456 1 - by flanking markers 5 45499544 90625569 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331774 rat Bp226 Blood pressure QTL 226 18 4.41065 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238 18 32105822 77105822 3 - by peak only 18 32494084 62302324 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331728 rat Bp214 Blood pressure QTL 214 7 2.825 33648 D7Mit5 33729 D7Mit10 40784 D7Rat135 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp215;Bp216 7 85089895 130953311 2 - by one flank and peak markers 7 85110626 131001042 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331729 rat Rf42 Renal function QTL 42 15 3.071 33713 D15Mit3 34222 D15Mgh8 34619 D15Mgh11 Renal function renal blood flow 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way decreased renal plasma flow rate;increased renal vascular resistance Kidney Diseases;Hypertension, Renal 70849 11721057 Bp223 15 19752934 80362100 2 - by one flank and peak markers 15 19348149 80377880 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331730 rat Scl27 Serum cholesterol level QTL 27 18 3.826 37738 D18Rat57 33884 D18Mit8 33884 D18Mit8 Lipid level HDL cholesterol 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased circulating HDL cholesterol level Hyperlipidemia 70849 11721057 Rf44;Scl28;Bw27 18 54605732 87265094 4 - by one flank marker only 18 54674164 62302324 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331731 rat Bp216 Blood pressure QTL 216 7 2.851 40784 D7Rat135 33780 D7Mit1 33729 D7Mit10 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp214;Bp215 7 108021523 141116504 1 - by flanking markers 7 108055754 141192941 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331732 rat Srn4 Serum renin concentration QTL 4 1 4.467 34037 D1Mit1 10337 D1Mgh5 33931 D1Mit10 Renin concentration serum 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased circulating renin level Kidney Diseases 70849 11721057 Rf27;Rf28;Rf29 1 33134446 78134446 4 - by one flank marker only 1 56717951 78212557 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331733 rat Bp233 Blood pressure QTL 233 18 3.97196 34550 D18Mgh9 36123 D18Rat9 37738 D18Rat57 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp234;Bp235;Bp236;Bp237;Bp238 18 25620884 72901291 1 - by flanking markers 18 25647530 83700976 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331734 rat Bp204 Blood pressure QTL 204 2 3.61192 10582 D2Mit12 35064 D2Rat64 34461 D2Mgh12 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Hr12;Cm29;Bp202;Bp203;Bp205;Bp206 2 188964312 232307864 2 - by one flank and peak markers 2 188903082 232294604 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331735 rat Rf44 Renal function QTL 44 18 2.981 34092 D18Mgh8 10689 D18Mit5 34550 D18Mgh9 Renal function urine protein level 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased protein excretion Proteinuria 70849 11721057 Scl27;Scl28;Bw27 18 15852436 35389472 2 - by one flank and peak markers 18 15879082 32494206 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331736 rat Bp227 Blood pressure QTL 227 18 2.791 36914 D18Rat18 33884 D18Mit8 37738 D18Rat57 Blood pressure diastolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial diastolic blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238 18 48759354 60452290 2 - by one flank and peak markers 18 48796977 62302324 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331737 rat Uae29 Urinary albumin excretion QTL 29 19 5.5 41262 D19Rat57 40904 D19Rat86 35881 D19Rat11 Renal function urine albumin level Animals on high or low salt diets were placed in metabolic cages and urine was collected for a 24 hour period. Albumin concentrations were measured with a rat-specific ELISA assay response to ammonium ion;increased protein excretion Proteinuria;Albuminuria 1300043 15161966 19 5975093 57235101 2 - by one flank and peak markers 19 5979685 57240161 2 - by one flank and peak markers 631695;1331809 SS/JrRkb;SHR/Rkb
1331738 rat Bp209 Blood pressure QTL 209 4 2.979 34174 D4Mgh7 34477 D4Mgh12 34477 D4Mgh12 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Hr13 4 161454762 187126005 3 - by peak only 4 161699886 187371129 3 - by peak only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331720 rat Rf43 Renal function QTL 43 17 2.881 34276 D17Mgh2 35302 D17Rat9 38348 D17Rat59 Renal function renal vascular resistance 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased renal vascular resistance Hypertension, Renal;Kidney Diseases 70849 11721057 Hr15 17 21286334 28903238 1 - by flanking markers 17 21286334 28905844 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331721 rat Bp210 Blood pressure QTL 210 5 3.413 34443 D5Mgh8 35823 D5Rat50 41492 D5Rat178 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate;increased systemic arterial blood pressure Hypertension;Heart Diseases 70849 11721057 5 149757277 173096209 2 - by one flank and peak markers 5 149767317 173106704 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331722 rat Thshl1 Thyroid stimulating hormone level QTL 1 6 11.7 1.0E-4 35659 D6Rat18 40144 D6Rat119 38634 D6Rat103 Thyroid stimulating hormone level serum was collected using the tail-cut method between the hours of 13:00- 15:00. TSH levels were measured using an RIA procedure obtained from Dr. Parlow at the National Hormone and Peptide Program increased circulating thyroid-stimulating hormone level Thyroid Diseases 1302891 15514085 3911;68418;68420 Tshr;Dio2;Dio3 6 93373975 111239430 1 - by flanking markers 6 93377605 111242961 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1331723 rat Bw25 Body weight QTL 25 7 3.348 35841 D7Rat19 33969 D7Mit4 40784 D7Rat135 Body weight increased body weight Obesity 70849 11721057 Kw9;Kw10 7 98568413 100273797 1 - by flanking markers 7 98602643 100308027 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331724 rat Bp223 Blood pressure QTL 223 15 3.53715 34222 D15Mgh8 34160 D15Mgh5 34409 D15Mgh9 Blood pressure systolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial systolic blood pressure Hypertension 70849 11721057 Rf42 15 80361961 102741337 1 - by flanking markers 15 80377742 102757117 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331725 rat Bp212 Blood pressure QTL 212 6 3.52475 33987 D6Mit8 33889 D6Mit16 40438 D6Rat163 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp213;Bp211 6 97561873 134379784 1 - by flanking markers 6 97565330 134385971 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331726 rat Bp208 Blood pressure QTL 208 3 3.129 33810 D3Mit2 34178 D3Mgh23 34304 D3Mgh18 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;decreased renal plasma flow rate Hypertension;Kidney Diseases 70849 11721057 Bp207 3 148614369 164269487 2 - by one flank and peak markers 3 143120240 164175523 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331727 rat Bp237 Blood pressure QTL 237 18 3.053 10689 D18Mit5 34043 D18Mit16 37738 D18Rat57 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp238 18 44311443 64900201 2 - by one flank and peak markers 18 32494084 64973402 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331739 rat Hrtrt14 Heart rate QTL 14 12 3.56232 35501 D12Rat2 34031 D12Mit7 37478 D12Rat43 Heart rate 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate;increased heart rate variability Hypertension;Cardiovascular Diseases 70849 11721057 Bp218;Bp219;Wbc2;Rf41 12 9628802 13205360 2 - by one flank and peak markers 12 9658731 17763471 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331740 rat Bw26 Body weight QTL 26 14 3.028 36536 D14Rat1 38932 D14Rat36 10134 D14Mit7 Body weight increased systemic arterial diastolic blood pressure;heart left ventricle hypertrophy;increased body weight Hypertension;Obesity;Heart Diseases 70849 11721057 14 4895894 33040140 1 - by flanking markers 14 4895895 33039940 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331741 rat Bp232 Blood pressure QTL 232 18 3.59112 34340 D18Mgh7 37104 D18Rat1 37738 D18Rat57 Blood pressure diastolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial diastolic blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238 18 22353754 86857890 2 - by one flank and peak markers 18 22417166 86931340 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331742 rat Bp228 Blood pressure QTL 228 18 3.88752 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238 18 32105822 77105822 3 - by peak only 18 32494084 62302324 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331743 rat Uae28 Urinary albumin excretion QTL 28 6 4.5 35911 D6Rat33 38006 D6Rat69 Renal function urine albumin level Animals on high or low salt diets were placed in metabolic cages and urine was collected for a 24 hour period. Albumin concentrations were measured with a rat-specific ELISA assay albuminuria;proteinuria Proteinuria;Albuminuria 1300043 15161966 6 1 28765971 3 - by peak only 6 0 28765971 3 - by peak only 631695;1331809 SS/JrRkb;SHR/Rkb
1331744 rat Bp217 Blood pressure QTL 217 8 3.398 33559 D8Mit5 33957 D8Mit16 33858 D8Mit4 Blood pressure systolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way proteinuria;increased systemic arterial systolic blood pressure Proteinuria;Hypertension 70849 11721057 Cm30;Rf39 8 32203394 61853629 1 - by flanking markers 8 32212161 61872683 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331745 rat Bp203 Blood pressure QTL 203 2 4.377 33727 D2Mit14 34495 D2Mgh29 34461 D2Mgh12 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure;increased systemic arterial diastolic blood pressure Hypertension 70849 11721057 Bp202;Bp204;Bp205;Bp206;Hr12;Cm29 2 197256223 227310008 1 - by flanking markers 2 197218978 227296688 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331746 rat Kidm9 Kidney mass QTL 9 7 3.934 33648 D7Mit5 33755 D7Mit13 33557 D7Mit14 Kidney mass right kidney mass 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way enlarged kidney Kidney Diseases 70849 11721057 Km10;Bw25 7 85089895 119050195 1 - by flanking markers 7 85110626 119084427 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331747 rat Hrtrt16 Heart rate QTL 16 20 3.163 34288 D20Mgh2 33997 D20Mit1 33997 D20Mit1 Heart rate 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate Heart Diseases 70849 11721057 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331748 rat Bp215 Blood pressure QTL 215 7 4.043 33755 D7Mit13 33780 D7Mit1 33729 D7Mit10 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp214;Bp216 7 119049926 141116504 1 - by flanking markers 7 119084157 141192941 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331749 rat Hrtrt11 Heart rate QTL 11 1 2.973 11439 D1Mit30 33878 D1Mit27 34381 D1Mgh7 Heart rate 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate Heart Diseases 70849 11721057 Bp198;Bp199;Bp200;Bp201 1 94473940 203303100 1 - by flanking markers 1 94552051 203456562 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331750 rat Bp220 Blood pressure QTL 220 13 2.98 34351 D13Mgh4 34483 D13Mgh9 11376 D13Mgh18 Blood pressure diastolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial diastolic blood pressure Hypertension 70849 11721057 Bp221;Bp222 13 38489801 83489801 4 - by one flank marker only 13 38503844 83503844 4 - by one flank marker only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331751 rat Bp199 Blood pressure QTL 199 1 3.60022 11439 D1Mit30 10951 D1Mit13 33959 D1Mit3 Blood pressure diastolic 10-week old male rats from the F2 generation were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial diastolic blood pressure Hypertension 70849 11721057 Bp198;Bp200;Bp201;Hr11 1 94473940 199469888 2 - by one flank and peak markers 1 94552051 186621913 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331752 rat Bw27 Body weight QTL 27 18 2.963 37738 D18Rat57 34182 D18Mgh3 33884 D18Mit8 Body weight increased body weight Obesity 70849 11721057 Rf44;Scl27;Scl28 18 54605732 69013448 1 - by flanking markers 18 54674164 69086649 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331753 rat Bp231 Blood pressure QTL 231 18 3.643 11461 D18Mit1 37738 D18Rat57 33606 D18Mit3 Blood pressure systolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial systolic blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238 18 54605912 80277473 1 - by flanking markers 18 12433620 54674343 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331754 rat Bp230 Blood pressure QTL 230 18 4.61609 34092 D18Mgh8 36123 D18Rat9 37738 D18Rat57 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp226;Bp227;Bp228;Bp229;Bp224;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238;Bp225 18 15852436 72901291 1 - by flanking markers 18 15879082 87338544 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331755 rat Bp219 Blood pressure QTL 219 12 3.041 37478 D12Rat43 34729 D12Mgh5 34031 D12Mit7 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp218;Hr14;Wbc2;Rf41 12 11416955 29130304 1 - by flanking markers 12 11446884 28993692 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331756 rat Rf34 Renal function QTL 34 5 4.16275 34226 D5Mgh1 33981 D5Mit4 34212 D5Mgh5 Renal function renal blood flow 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way decreased renal plasma flow rate Kidney Diseases 70849 11721057 Rf32;Rf33;Rf35;Rf36;Scl26 5 1 94516069 2 - by one flank and peak markers 5 0 94521182 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331757 rat Cdexp1 CD45RC expression in CD8 T cells QTL 1 9 4.3 17.5 631290 D9Wox24 44552 D9Wox21 60669 D9Got8 CD8 T cell CD45RC expression level CD8 T cells were negatively selected from lymph node and spleen cells. Using flow cytometry, CD45RC(low) and CD45RC(high) CD8 T-cell subpopulations were quantitated. abnormal CD8-positive T cell morphology Autoimmune Diseases 1302824 15322174 recessive 9 1 26311566 3 - by peak only 9 0 26311566 3 - by peak only 631593;631594 LEW/Rj;BN/Rj
1331758 rat Bp207 Blood pressure QTL 207 3 2.848 33838 D3Mit18 33927 D3Mit3 33808 D3Mit4 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp208 3 125975226 136402080 2 - by one flank and peak markers 3 112240305 136307653 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331759 rat Hrtrt13 Heart rate QTL 13 4 3.54628 33991 D4Mit28 33832 D4Mit27 11377 D4Mit1 Heart rate 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart rate;increased heart rate variability Hypertension;Cardiovascular Diseases 70849 11721057 Bp209 4 111754988 172369380 1 - by flanking markers 4 111999469 172614316 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331760 rat Bp206 Blood pressure QTL 206 2 3.62454 34334 D2Mgh21 34461 D2Mgh12 10387 D2Mgh26 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp202;Bp203;Bp204;Bp205;Hr12;Cm29 2 56214854 210636169 1 - by flanking markers 2 56143087 210598923 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331761 rat Bp218 Blood pressure QTL 218 12 2.973 37478 D12Rat43 34455 D12Mgh8 34729 D12Mgh5 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp219;Hr14;Wbc2;Rf41 12 11416955 46782294 2 - by one flank and peak markers 12 11446884 46540376 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331762 rat Rf40 Renal function QTL 40 10 3.873 34359 D10Mgh11 34648 D10Mgh14 34359 D10Mgh11 Renal function renal vascular resistance 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased renal vascular resistance Kidney Diseases;Hypertension, Renal 70849 11721057 10 29974190 65379965 1 - by flanking markers 10 29975240 65393588 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331779 rat Rf38 Renal function QTL 38 6 2.876 34138 D6Mgh8 11241 D6Mit3 34184 D6Mgh11 Renal function renal vascular resistance 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal vascular resistance;kidney failure Hypertension 70849 11721057 Rf37 6 32764436 75049644 1 - by flanking markers 6 32767389 75052770 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331780 rat Bp238 Blood pressure QTL 238 18 3.269 36914 D18Rat18 33884 D18Mit8 37738 D18Rat57 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237 18 48759354 60452290 2 - by one flank and peak markers 18 48796977 62302324 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331781 rat Scl28 Serum cholesterol level QTL 28 18 3.995 11461 D18Mit1 34550 D18Mgh9 34340 D18Mgh7 Lipid level HDL cholesterol 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased circulating cholesterol level Hypercholesterolemia 70849 11721057 Rf44;Scl27;Bw27 18 25621024 80277473 1 - by flanking markers 18 12433620 25647670 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331782 rat Rf36 Renal function QTL 36 5 3.296 40386 D5Rat131 39378 D5Rat149 33981 D5Mit4 Renal function renal blood flow 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal plasma flow rate Hypertension 70849 11721057 Rf32;Rf33;Rf34;Rf35;Scl26 5 35390492 101506667 1 - by flanking markers 5 35390671 101511887 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331783 rat Bp221 Blood pressure QTL 221 13 3.72886 37844 D13Rat85 33644 D13Mit4 33644 D13Mit4 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial diastolic blood pressure;increased systemic arterial blood pressure Hypertension 70849 11721057 Bp220;Bp222 13 72141292 90551272 1 - by flanking markers 13 72155481 90740156 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331784 rat Bp222 Blood pressure QTL 222 13 2.944 34076 D13Mgh1 33947 D13Mit9 34351 D13Mgh4 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp220;Bp221 13 7538626 55033994 1 - by flanking markers 13 7538626 55048384 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331785 rat Rf27 Renal function QTL 27 1 4.643 35885 D1Rat8 10337 D1Mgh5 34433 D1Mgh3 Renal function urine sodium concentration 10-week old male rats from the F2 generation were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way pathway-restricted SMAD protein phosphorylation Kidney Diseases;Hypertension, Renal 70849 11721057 Rf28;Rf29;Srn4 1 29683185 78134446 1 - by flanking markers 1 29686130 78212557 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331786 rat Kidm11 Kidney mass QTL 11 12 3.571 37478 D12Rat43 34246 D12Mgh3 34031 D12Mit7 Kidney mass right kidney mass 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased kidney weight;enlarged kidney Hypertension 70849 11721057 Rf41;Bp218;Bp219;Hr14 12 11416955 25271941 1 - by flanking markers 12 11446884 25135323 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331787 rat Rf41 Renal function QTL 41 12 2.998 34086 D12Mgh9 34729 D12Mgh5 34086 D12Mgh9 Renal function renal blood flow 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal plasma flow rate Hypertension 70849 11721057 Km11;Bp218;Bp219;Hr14 12 29130304 41447755 1 - by flanking markers 12 28993692 41311143 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331788 rat Rf45 Renal function QTL 45 19 2.818 33917 D19Mit4 34743 D19Mit14 33602 D19Mit10 Renal function renal blood flow 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal plasma flow rate Hypertension 70849 11721057 19 16770857 49024175 2 - by one flank and peak markers 19 16775647 49029149 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331789 rat Rf37 Renal function QTL 37 6 3.224 11241 D6Mit3 40438 D6Rat163 33987 D6Mit8 Renal function renal vascular resistance 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal vascular resistance;abnormal urination pattern 70849 11721057 Rf38 6 75049527 120074417 2 - by one flank and peak markers 6 75052653 120078205 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331790 rat Bp201 Blood pressure QTL 201 1 3.127 33878 D1Mit27 34009 D1Mit34 33945 D1Mit18 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp198;Bp199;Bp200;Hr11 1 203302907 230963799 1 - by flanking markers 1 203456204 231127822 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331791 rat Cm31 Cardiac mass QTL 31 10 3.84606 34359 D10Mgh11 10466 D10Mit1 34718 D10Mgh23 Cardiac mass 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart weight;increased systemic arterial blood pressure Hypertension;Cardiomegaly 70849 11721057 10 29974190 95369088 1 - by flanking markers 10 29975240 95383458 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331792 rat Rf29 Renal function QTL 29 1 4.589 34037 D1Mit1 10337 D1Mgh5 33931 D1Mit10 Renal function urine potassium concentration 10-week old male rats from the F2 generation were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased potassium excretion Kidney Diseases 70849 11721057 Rf27;Rf28;Srn4 1 33134446 78134446 4 - by one flank marker only 1 56717951 78212557 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331793 rat Bp200 Blood pressure QTL 200 1 3.71601 11439 D1Mit30 34399 D1Mgh9 34011 D1Mit2 Blood pressure systolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial systolic blood pressure Hypertension 70849 11721057 Bp198;Bp199;Bp201;Hr11 1 94473940 176855135 1 - by flanking markers 1 94552051 176994381 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331794 rat Bp202 Blood pressure QTL 202 2 3.66819 34114 D2Mgh15 35064 D2Rat64 34495 D2Mgh29 Blood pressure systolic 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial systolic blood pressure Hypertension 70849 11721057 Bp203;Bp204;Bp205;Bp206;Hr12;Cm29 2 146228221 232307864 1 - by flanking markers 2 146178185 232294604 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331795 rat Rf30 Renal function QTL 30 3 3.708 34336 D3Mgh7 35380 D3Rat27 34146 D3Mgh6 Renal function urine potassium concentration 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal kidney excretion;abnormal urine osmolality Hypertension 70849 11721057 3 36556706 87981257 1 - by flanking markers 3 36453079 87877685 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331796 rat Thshl2 Thyroid stimulating hormone level QTL 2 5 2.3 39378 D5Rat149 37864 D5Rat93 40262 D5Rat157 Thyroid stimulating hormone level serum was collected using the tail-cut method between the hours of 13:00- 15:00. TSH levels were measured using an RIA procedure obtained from Dr. Parlow at the National Hormone and Peptide Program increased circulating thyroid-stimulating hormone level Thyroid Diseases 1302891 15514085 2504 Dio1 5 101506332 154014139 1 - by flanking markers 5 101511690 154024178 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1331797 rat Bp213 Blood pressure QTL 213 6 3.291 34126 D6Mgh4 33889 D6Mit16 39256 D6Rat78 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp211;Bp212 6 134379600 138919812 2 - by one flank and peak markers 6 108507129 134385971 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331798 rat Bp224 Blood pressure QTL 224 18 3.53873 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp225;Bp226;Bp227;Bp228;Bp229;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238 18 32105822 77105822 3 - by peak only 18 32494084 62302324 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331799 rat Bp211 Blood pressure QTL 211 6 3.66407 11241 D6Mit3 39256 D6Rat78 40438 D6Rat163 Blood pressure time series calculation 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp212;Bp213 6 75049527 136649854 1 - by flanking markers 6 75052653 136656041 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331800 rat Scl25 Serum cholesterol level QTL 25 1 3.013 11439 D1Mit30 34011 D1Mit2 34381 D1Mgh7 Lipid level cholesterol 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased circulating cholesterol level Hypercholesterolemia 70849 11721057 1 94473940 134980682 1 - by flanking markers 1 94552051 135059025 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331801 rat Rf33 Renal function QTL 33 5 4.149 34212 D5Mgh5 34583 D5Rjr1 10826 D5Mgh23 Renal function renal vascular resistance 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal vascular resistance;kidney failure Hypertension 70849 11721057 Rf32;Rf34;Rf35;Rf36;Scl26 5 45499364 135916908 1 - by flanking markers 5 45499544 135916119 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331802 rat Srn5 Serum renin concentration QTL 5 4 3.045 36554 D4Rat47 11377 D4Mit1 34174 D4Mgh7 Renin concentration serum 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal circulating renin level Hypertension 70849 11721057 Rf31 4 115896404 160896404 4 - by one flank marker only 4 116141340 161141340 4 - by one flank marker only 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331803 rat Rf32 Renal function QTL 32 5 2.798 34583 D5Rjr1 34443 D5Mgh8 34443 D5Mgh8 Renal function renal vascular resistance 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal renal vascular resistance;kidney failure Hypertension 70849 11721057 Rf33;Rf34;Rf35;Rf36;Scl26 5 135900621 149757440 1 - by flanking markers 5 135915945 149767479 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331804 rat Cm30 Cardiac mass QTL 30 8 3.77443 35663 D8Rat51 11225 D8Mgh15 33913 D8Mit13 Cardiac mass 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart weight;increased body weight Cardiomegaly;Obesity 70849 11721057 Bp217;Rf39 8 29559446 103672447 1 - by flanking markers 8 29565716 103691902 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331805 rat Cm29 Cardiac mass QTL 29 2 3.50746 34114 D2Mgh15 35064 D2Rat64 34461 D2Mgh12 Cardiac mass 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased heart weight Cardiomegaly 70849 11721057 Bp202;Bp203;Bp204;Bp205;Bp206;Hr12 2 146228221 232307864 1 - by flanking markers 2 146178185 232294604 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331806 rat Bp229 Blood pressure QTL 229 18 4.36484 36914 D18Rat18 36123 D18Rat9 37738 D18Rat57 Blood pressure mean arterial 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way increased systemic arterial blood pressure Hypertension 70849 11721057 Bp224;Bp225;Bp226;Bp227;Bp228;Bp230;Bp231;Bp232;Bp233;Bp234;Bp235;Bp236;Bp237;Bp238 18 48759354 72901291 1 - by flanking markers 18 48796977 60551529 2 - by one flank and peak markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331807 rat Rf31 Renal function QTL 31 4 2.988 34238 D4Mgh2 34230 D4Mgh24 33757 D4Mit2 Renal function urine potassium concentration 10-week old male rats were given a high-salt diet (8% NaCl), fitted with a femoral catheter, and housed in metabolic cages, allowing multiple traits related to blood pressure and cardiac function to be measured in a conscious unrestrained way abnormal kidney excretion;abnormal urine osmolality Hypertension 70849 11721057 Srn5 4 36611842 73752590 1 - by flanking markers 4 36730383 74028720 1 - by flanking markers 10008;61499 BN/SsNHsd;SS/JrHsdMcwi
1331837 rat Bw23 Body weight QTL 23 8 4.19 7.0E-5 10178 D8Wox4 11223 D8Wox6 44494 D8Got144 Body weight increased body weight Obesity 1300044 15164172 8 85328126 103665018 2 - by one flank and peak markers 8 85347581 103684473 2 - by one flank and peak markers 10017;60985;1331813;1331814 GK/KyoSwe;BN;BN.GK-(D8Rat29-D8Got130)/Ox;BN.GK-(D8Got302-D8Got130)/Ox
1331838 rat Niddm61 Non-insulin dependent diabetes mellitus QTL 61 8 3.53 4.0E-4 10819 D8Got43 11223 D8Wox6 44445 D8Got99 Insulin level fasting after a 16 to 18 hour fast, blood samples were collected from animals at 12 and 24 weeks of age increased insulin secretion;increased circulating insulin level Diabetes Mellitus, Non-Insulin-Dependent 1300044 15164172 8 38003289 103665018 1 - by flanking markers 8 38012056 103684473 1 - by flanking markers 10017;60985;1331813;1331814 GK/KyoSwe;BN;BN.GK-(D8Rat29-D8Got130)/Ox;BN.GK-(D8Got302-D8Got130)/Ox
1331839 rat Eae18b Experimental allergic encephalomyelitis QTL 18b 10 5.8 0.03 42921 D10Rat243 36916 D10Rat58 37170 D10Rat123 Brain/spinal cord inflammation maximum score experimental allergic encephalomyelitis was induced by injection with myelin oligodendrocyte glycoprotein and monitored daily beginning on day 10 p.i. for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-5. paralysis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 1302437 15240732 recessive 10 67774947 71067824 1 - by flanking markers 10 67788570 71081447 1 - by flanking markers 1331833 DA.ACI-(D10Rat15-D10Rat29) Intercross
1358912 rat Bw51 Body weight QTL 51 8 2.95 35388 D8Rat37 37072 D8Rat59 39574 D8Rat139 Body weight increased body weight Obesity 1303386 14640890 8 54364071 112242906 1 - by flanking markers 8 54383126 112262361 1 - by flanking markers 60999;1302795 LEW;HTG
1358913 rat Cm41 Cardiac mass QTL 41 2 2.73 38576 D2Rat182 35693 D2Rat55 38266 D2Rat136 Cardiac mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased heart weight Cardiomegaly 1303386 14640890 2 24474447 212169089 1 - by flanking markers 2 24394817 212131843 1 - by flanking markers 60999;1302795 LEW;HTG
1358914 rat Bp266 Blood pressure QTL 266 7 39938 D7Rat141 39652 D7Rat115 35681 D7Rat5 Blood pressure post sympathetic nervous system block mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight increased systemic arterial blood pressure Hypertension 1303386 14640890 7 88583730 143002779 2 - by one flank and peak markers 7 88604461 142521474 1 - by flanking markers 60999;1302795 LEW;HTG
1358915 rat Stresp7 Stress response QTL 7 10 3.52 9.6 34718 D10Mgh23 11308 D10Wox20 11308 D10Wox20 Hormone level norepinephrine animals at 4 months of age were catherterized into the carotid artery for blood pressure measurement and subjected to immobilization stress for two hours. Blood catecholamine levels were determined after 20 min using a radioenzymatic method; early and late variation in plasma epinephrine and NE levels were determined. increased circulating noradrenaline level 1332590 15547139 codominant 10 68955627 110718848 3 - by peak only 10 82598694 91470053 1 - by flanking markers 1302795;1354669 HTG;BN/OrlIcoCrlf
1358916 rat Kidm22 Kidney mass QTL 22 1 3.32 36757 D1Rat71 10674 D1Mgh12 43423 D1Got228 Kidney mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades;renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased kidney weight Hypertension 1303386 14640890 1 216662939 247322277 1 - by flanking markers 1 216821440 247436752 1 - by flanking markers 60999;1302795 LEW;HTG
1358917 rat Cm42 Cardiac mass QTL 42 2 2.82 38576 D2Rat182 35693 D2Rat55 41538 D2Rat199 Cardiac mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased heart weight Cardiomegaly 1303386 14640890 2 24474447 212169089 1 - by flanking markers 2 24394817 212131843 1 - by flanking markers 60999;1302795 LEW;HTG
1357990 rat Ael1 Aortic elastin QTL 1 2 3.1 9.1E-4 9.2 43467 D2Got24 Protein level aortic elastin At 18 weeks of age, body and heart weight were measured. Measurements of the thoracic aorta were taken (dry weight, cell protein, elastin and collagen contents). decreased aorta elastin content Cardiovascular Diseases 1334448 15668357 dominant 2 18905511 63905511 3 - by peak only 2 18825880 63825880 3 - by peak only 60985;1357985 BN;LOU/Ins
1357991 rat Ael2 Aortic elastin QTL 2 2 4.2 7.1E-5 10201 D2Wox26 Protein level aortic elastin At 18 weeks of age, body and heart weight were measured. Measurements of the thoracic aorta were taken (dry weight, cell protein, elastin and collagen contents). decreased aorta elastin content Cardiovascular Diseases 1334448 15668357 recessive 60985;1357985 BN;LOU/Ins
1358352 rat Srcrt3 Stress Responsive Cort QTL 3 4 2.29 35847 D4Rat12 36143 D4Rat60 38656 D4Rat128 Hypothalamic-pituitary-adrenal axis corticosterone post-stress blood was taken after 10 minutes of restraint stress abnormal corticosterone level 1598980 16895972 4 8819982 149560340 2 - by one flank and peak markers 4 9127401 149805181 2 - by one flank and peak markers 61105;61109 WKY/NHsd;F344/NHsd
1358353 rat Srcrtb2 Stress Responsive Cort Basal QTL 2 5 3.48 0.003 40716 D5Rat124 34144 D5Mgh11 40386 D5Rat131 Hypothalamic-pituitary-adrenal axis corticosterone blood was taken within 2 minutes of removing rat from the cage abnormal corticosterone level 1598980 16895972 5 19206257 77484299 1 - by flanking markers 5 19206258 77489412 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1358354 rat Srcrt5 Stress Responsive Cort QTL 5 15 3.38 39122 D15Rat40 35321 D15Rat27 38106 D15Rat50 Hypothalamic-pituitary-adrenal axis corticosterone post-stress blood was taken after 10 minutes of restraint stress increased circulating corticosterone level 1598980 16895972 15 106152589 107060711 2 - by one flank and peak markers 15 106168381 107076479 2 - by one flank and peak markers 61105;61109 WKY/NHsd;F344/NHsd
1358355 rat Srcrt4 Stress Responsive Cort QTL 4 6 6.39 38634 D6Rat103 36191 D6Rat6 39650 D6Rat111 Hypothalamic-pituitary-adrenal axis corticosterone post-stress blood was taken after 10 minutes of restraint stress decreased circulating corticosterone level 1598980 16895972 1595901 Serpina6 6 104481235 123455207 1 - by flanking markers 6 104484691 147642806 2 - by one flank and peak markers 61105;61109 WKY/NHsd;F344/NHsd
1358356 rat Srcrt1 Stress Responsive Cort QTL1 2 3.66 39076 D2Rat170 36962 D2Rat63 39118 D2Rat139 Hypothalamic-pituitary-adrenal axis corticosterone post-stress blood was taken after 10 minutes of restraint stress increased circulating corticosterone level 1598980 16895972 2 167857161 231465091 1 - by flanking markers 2 167807215 231451831 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1358357 rat Srcrtb1 Stress Responsive Cort Basal QTL 1 3 6.36 0.002 34186 D3Mgh9 37010 D3Rat49 35054 D3Rat55 Hypothalamic-pituitary-adrenal axis corticosterone blood was taken within 2 minutes of removing rat from the cage abnormal corticosterone level 1598980 16895972 3 4010230 23762628 1 - by flanking markers 3 4010230 23659000 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1358358 rat Sradr6 Stress Responsive Adrenal Weight QTL 6 18 2.49 11461 D18Mit1 37412 D18Rat40 39444 D18Rat96 Hypothalamic-pituitary-adrenal axis adrenal gland weight adrenal glands were collected and weighed after 1 month of mild stress abnormal adrenal gland morphology 1598980 16895972 18 62106220 80277473 1 - by flanking markers 18 12433620 62179421 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1358359 rat Sradr1 Stress Responsive Adrenal Weight QTL 1 1 4.74 34037 D1Mit1 36432 D1Rat35 35308 D1Rat24 Hypothalamic-pituitary-adrenal axis adrenal gland weight adrenal glands were collected and weighed after 1 month of mild stress abnormal adrenal gland morphology 1598980 16895972 1 28716493 124749065 2 - by one flank and peak markers 1 56717951 124827408 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1358360 rat Sradr2 Stress Responsive Adrenal Weight QTL 2 2 10.24 38960 D2Rat93 38522 D2Rat164 41152 D2Rat220 Hypothalamic-pituitary-adrenal axis adrenal gland weight adrenal glands were collected and weighed after 1 month of mild stress abnormal adrenal gland morphology 1598980 16895972 2 133459258 157917105 1 - by flanking markers 2 133409327 157867068 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1359030 rat Bp277 Blood pressure QTL 277 2 38362 D2Rat161 10712 D2Mgh10 Blood pressure systolic systolic, diastolic, mean arterial blood pressures, heart rate, and locomoter activity were measured in congenic strains and substrains carrying various chromosome 2 segments and compared to the parental strains during standard and 8% salt diets decreased systemic arterial blood pressure Hypertension 629618 12209022 2 118264490 163264490 4 - by one flank marker only 2 118209465 163209465 4 - by one flank marker only 1358992 SHR.WKY-(D2Rat40-D2Rat50)
1359031 rat Bp275 Blood pressure QTL 275 2 10712 D2Mgh10 35849 D2Rat62 Blood pressure systolic systolic, diastolic, mean arterial blood pressures, heart rate, and locomoter activity were measured in congenic strains and substrains carrying various chromosome 2 segments and compared to the parental strains during standard and 8% salt diets increased systemic arterial systolic blood pressure Hypertension 629618 12209022 2 183664122 228664122 4 - by one flank marker only 2 183650862 228650862 4 - by one flank marker only 1359001 WKY.SHR-(D2Rat42-D2Rat139)
1359032 rat Hrtrt18 Heart rate QTL 18 2 36213 D2Rat40 36773 D2Rat50 Heart rate salt-induced bradycardia systolic, diastolic, mean arterial blood pressures, heart rate, and locomoter activity were measured in congenic strains and substrains carrying various chromosome 2 segments and compared to the parental strains during standard and 8% salt diets abnormal heart rate;decreased heart rate Heart Diseases;Bradycardia 629618 12209022 2 163154227 200390471 1 - by flanking markers 2 163104191 200353226 1 - by flanking markers 1358992 SHR.WKY-(D2Rat40-D2Rat50)
1359033 rat Bp273 Blood pressure QTL 273 8 33559 D8Mit5 34415 D8Mgh6 Blood pressure response to intrathecal cytisine Animals were implanted with catheters for spinal drug delivery. Four to five days later, the tail artery was catheterized for measurement of blood pressure and heart rate. Nociceptive response was measured by scoring behaviorial responses to irritation sensitivity such as body movement and squeaking decreased systemic arterial blood pressure;abnormal touch/ nociception Hypertension 1358955 12388796 2345;2347;2351 Chrna3;Chrna5;Chrnb4 8 32203394 64762616 1 - by flanking markers 8 32212161 64781670 1 - by flanking markers 61106 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv
1359034 rat Bp274 Blood pressure QTL 274 2 35643 D2Rat21 35148 D2Rat27 Blood pressure systolic systolic, diastolic, mean arterial blood pressures, heart rate, and locomoter activity were measured in congenic strains and substrains carrying various chromosome 2 segments and compared to the parental strains during standard and 8% salt diets increased systemic arterial systolic blood pressure Hypertension 629618 12209022 2 75806326 96482076 1 - by flanking markers 2 75734560 96426854 1 - by flanking markers 1358999 WKY.SHR-(D2Rat174-D2Rat28)
1359035 rat Bp276 Blood pressure QTL 276 2 38362 D2Rat161 34005 D2Mit8 Blood pressure systolic systolic, diastolic, mean arterial blood pressures, heart rate, and locomoter activity were measured in congenic strains and substrains carrying various chromosome 2 segments and compared to the parental strains during standard and 8% salt diets decreased systemic arterial blood pressure Hypertension 629618 12209022 2 118264490 148790758 1 - by flanking markers 2 118209465 148740721 1 - by flanking markers 1359006 WKY.SHR-(D2Rat27-D2Rat243)
1357335 rat Bw39 Body weight QTL 39 1 3.3 32.0 2870 Igf2 10674 D1Mgh12 Body weight increased body weight Obesity 69707;1303386 9530522;14640890 1 202906624 247322277 1 - by flanking markers 1 203094689 247436752 1 - by flanking markers 61107;61110 BB/OK;SHR/Mol backcross
1357336 rat Gluco6 Glucose level QTL 6 7 3.4 33755 D7Mit13 631288 D7Cebr77s1 33749 D7Mit3 Glucose level plasma glucose insulin/glucose ratio was measured in male rats under a 60% fructose diet which was associated to the serum glucose level during the intraperitoneal glucose tolerance test impaired glucose tolerance;abnormal glucose tolerance Glucose Intolerance;Insulin Resistance 619533 12016513 additive 7 91775445 119050195 2 - by one flank and peak markers 7 91809705 119084427 2 - by one flank and peak markers 629499 BXS
1357337 rat Gluco3 Glucose level QTL 3 12 1.9 34025 D12Mit8 34439 D12Mgh1 Glucose level insulin-mediated glucose uptake insulin mediated and basal glucose uptake levels were measured in adipocytes isolated from male rats abnormal glucose homeostasis Diabetes Mellitus, Non-Insulin-Dependent;Metabolic Syndrome X 61078 9171835 dominant 12 1 12240883 4 - by one flank marker only 61096;61097 SHR/NCruk;WKY/NCruk
1357338 rat Stl17 Serum triglyceride level QTL 17 7 3.23 34096 D7Mgh4 34499 D7Mgh7 34555 D7Mgh6 Lipid level triglyceride blood samples were obtained from 28, 30 and 32 weeks old females by punturing the opthalmic venous plexus and serum triglycerides were analysed using an automatic analyser increased circulating triglyceride level Hyperlipidemia 1357168 11374884 7 74244916 119494569 1 - by flanking markers 7 74265646 119528799 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357339 rat Stl14 Serum triglyceride level QTL 14 7 3.45 1.0E-4 33780 D7Mit1 34096 D7Mgh4 33670 D7Mit2 Lipid level triglyceride blood samples were obtained from 28, 30 and 32 weeks old females by punturing the opthalmic venous plexus and serum triglycerides were analysed using an automatic analyser increased circulating triglyceride level Metabolic Syndrome X;Hypertriglyceridemia 1357168 11374884 7 119494698 141116327 1 - by flanking markers 7 119528928 141192765 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357340 rat Bp250 Blood pressure QTL 250 10 1.0E-4 33941 D10Mit11 631289 D10M11Mit119 Blood pressure increased systemic arterial blood pressure Hypertension 619625 9607182 10 101848470 110718848 4 - by one flank marker only 10 101862784 110733352 4 - by one flank marker only 631588;728390 SS.MNS-(D10Mit11-Vamp2)/Mco;SS.MNS-(D10Mit11-D10M11Mit119)
1357341 rat Gluco5 Glucose level QTL 5 4 3522 Rt8_mapped Glucose level insulin-mediated glucose uptake insulin mediated and basal glucose uptake levels were measured in adipocytes isolated from male rats abnormal glucose homeostasis Diabetes Mellitus, Non-Insulin-Dependent;Metabolic Syndrome X 61078 9171835 recessive 61098;61099 BXH;HXB
1357342 rat Bw40 Body weight QTL 40 4 0.001 60732 D4Mit6 3753 Spr Body weight increased body weight Obesity 69707 9530522 3197;3753 Npy;Spr 4 75732943 119369308 1 - by flanking markers 4 74613765 119613765 4 - by one flank marker only 61107;1357346 BB/OK;BB.SHR-(D4Mit6-Spr)/K
1357343 rat Gluco4 Glucose level QTL 4 4 3.1 11310 D4Bro1 Glucose level insulin-mediated glucose uptake insulin mediated and basal glucose uptake levels were measured in adipocytes isolated from male rats abnormal glucose homeostasis Diabetes Mellitus, Non-Insulin-Dependent;Metabolic Syndrome X 61078 9171835 recessive 4 1 28615362 3 - by peak only 4 0 28615362 3 - by peak only 61096;61097 SHR/NCruk;WKY/NCruk
1357344 rat Bp249 Blood pressure QTL 249 10 1.0E-4 66552 D10Mco1 66563 D10Mco6 Blood pressure increased systemic arterial blood pressure Hypertension 619626 9096100 10 69986912 102587587 1 - by flanking markers 10 70000535 102601957 1 - by flanking markers 631587;631588 SS.MNS-(D10M11Mit119-D10Mit11)/Jr;SS.MNS-(D10Mit11-Vamp2)/Mco
1358885 rat Bp251 Blood pressure QTL 251 3 3.8 0.06 35617 D3Rat54 36717 D3Rat17 40122 D3Rat186 Blood pressure mean arterial mean arterial blood pressure was measured in the (HTG x LEW) F2 population 5-6 month of age at baseline and after the following pharmoclogical blockades of blood pressure regulation: renin-angiotensin system block by lorsatin), sympathetic nervous system block by pentolinium), and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased systemic arterial blood pressure Hypertension 1303389 12545249 3 10267741 121619110 1 - by flanking markers 3 10163121 121524683 1 - by flanking markers 60999;1302795 LEW;HTG
1358886 rat Bp260 Blood pressure QTL 260 1 3.67 43423 D1Got228 38564 D1Rat140 36757 D1Rat71 Blood pressure post nitric oxide system block mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight increased systemic arterial blood pressure Hypertension 1303386 14640890 1 154075310 231726050 1 - by flanking markers 1 154153698 231890074 1 - by flanking markers 60999;1302795 LEW;HTG
1358887 rat Bw50 Body weight QTL 50 2 2.39 36213 D2Rat40 38576 D2Rat182 35250 D2Rat13 Body weight increased body weight Obesity 1303386 14640890 2 24474676 163154227 1 - by flanking markers 2 24395045 163104191 1 - by flanking markers 60999;1302795 LEW;HTG
1358888 rat Bp264 Blood pressure QTL 264 3 4.43 35617 D3Rat54 36717 D3Rat17 34146 D3Mgh6 Blood pressure mean arterial mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight increased systemic arterial blood pressure Hypertension 1303386 14640890 3 10267741 121619110 1 - by flanking markers 3 10163121 121524683 1 - by flanking markers 60999;1302795 LEW;HTG
1358889 rat Bp261 Blood pressure QTL 261 5 2.86 37242 D5Rat77 38338 D5Rat108 60808 D5Wox25 Blood pressure mean arterial mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight increased systemic arterial blood pressure Hypertension 1303386 14640890 5 94084025 134872385 2 - by one flank and peak markers 5 94089552 134877312 2 - by one flank and peak markers 60999;1302795 LEW;HTG
1358890 rat Bp259 Blood pressure QTL 259 1 3.06 36757 D1Rat71 10674 D1Mgh12 41418 D1Rat304 Blood pressure mean arterial mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight increased systemic arterial blood pressure Hypertension 1303386 14640890 1 216662939 247322277 1 - by flanking markers 1 216821440 247436752 1 - by flanking markers 60999;1302795 LEW;HTG
1358891 rat Bp265 Blood pressure QTL 265 7 2.21 39938 D7Rat141 39652 D7Rat115 40784 D7Rat135 Blood pressure post renin-angiotensin system block mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight increased systemic arterial blood pressure Hypertension 1303386 14640890 7 88583730 127459476 2 - by one flank and peak markers 7 88604461 142521474 1 - by flanking markers 60999;1302795 LEW;HTG
1358892 rat Kidm26 Kidney mass QTL 26 8 3.69 41522 D8Rat164 11222 D8Mgh3 36235 D8Rat35 Kidney mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) decreased kidney weight;increased kidney weight Hypertension 1303386 14640890 8 28414004 103684785 1 - by flanking markers 8 28414101 103704240 1 - by flanking markers 60999;1302795 LEW;HTG
1358893 rat Bp263 Blood pressure QTL 263 8 5.01 36904 D8Rat19 38484 D8Rat171 37072 D8Rat59 Blood pressure post sympathetic nervous system block mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight decreased systemic arterial blood pressure Hypertension 1303386 14640890 8 98451122 127956046 1 - by flanking markers 8 98470706 127976037 1 - by flanking markers 60999;1302795 LEW;HTG
1358894 rat Kidm24 Kidney mass QTL 24 2 4.03 38576 D2Rat182 36213 D2Rat40 38576 D2Rat182 Kidney mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacolgical blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased kidney weight;decreased kidney weight Hypertension 1303386 14640890 2 2 24474447 163154358 1 - by flanking markers 2 24394817 163104321 1 - by flanking markers 60999;1302795 LEW;HTG
1358895 rat Bp254 Blood pressure QTL 254 5 3.6 3.0E-4 36177 D5Rat9 38338 D5Rat108 41424 D5Rat156 Blood pressure mean arterial mean arterial blood pressure was measured in the (HTG x LEW) F2 population 5-6 month of age at baseline and after the following pharmoclogical blockades of blood pressure regulation: renin-angiotensin system block by lorsatin), sympathetic nervous system block by pentolinium), and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased systemic arterial blood pressure Hypertension 1303389;2316920 12545249;19556729 5 61080077 134872385 1 - by flanking markers 5 61080322 134877312 1 - by flanking markers 60999;1302795 LEW;HTG
1358896 rat Bp262 Blood pressure QTL 262 8 2.89 41522 D8Rat164 11222 D8Mgh3 36235 D8Rat35 Blood pressure post sympathetic nervous system block mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME); heart and kidneys were weighed and normalized per whole body weight decreased systemic arterial blood pressure Hypertension 1303386 14640890 8 28414004 103684785 1 - by flanking markers 8 28414101 103704240 1 - by flanking markers 60999;1302795 LEW;HTG
1358897 rat Stresp6 Stress response QTL 6 10 4.17 0.022 10.2 33909 D10Mit4 34648 D10Mgh14 10949 D10Wox11 Hormone level norepinephrine animals at 4 months of age were catherterized into the carotid artery for blood pressure measurement and subjected to immobilization stress for two hours. Blood catecholamine levels were determined after 20 min using a radioenzymatic method; early and late variation in plasma epinephrine and NE levels were determined. increased circulating noradrenaline level 1332590 15547139 dominant 10 36649906 65379965 1 - by flanking markers 10 36650904 65393588 1 - by flanking markers 1302795;1354669 HTG;BN/OrlIcoCrlf
1358898 rat Bp255 Blood pressure QTL 255 1 3.6 37732 D1Rat208 41060 D1Rat307 Blood pressure post nitric oxide system block mean arterial blood pressure was measured in the (HTG x LEW) F2 population 5-6 month of age at baseline and after the following pharmoclogical blockades of blood pressure regulation: renin-angiotensin system block by lorsatin), sympathetic nervous system block by pentolinium), and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased systemic arterial blood pressure Hypertension 1303389 12545249 1 195927908 240927908 4 - by one flank marker only 1 196077900 252762370 1 - by flanking markers 60999;1302795 LEW;HTG
1358899 rat Kidm23 Kidney mass QTL 23 2 3.88 38576 D2Rat182 36213 D2Rat40 41538 D2Rat199 Kidney mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacolgical blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased kidney weight;decreased kidney weight Hypertension 1303386 14640890 2 24474447 163154358 1 - by flanking markers 2 24394817 163104321 1 - by flanking markers 60999;1302795 LEW;HTG
1358900 rat Bw48 Body weight QTL 48 2 4.88 35915 D2Rat61 36213 D2Rat40 34234 D2Mgh9 Body weight increased body weight Obesity 1303386 14640890 2 163154358 227150051 1 - by flanking markers 2 163104321 227136731 1 - by flanking markers 60999;1302795 LEW;HTG
1358901 rat Cm38 Cardiac mass QTL 38 2 2.0 38576 D2Rat182 36213 D2Rat40 39512 D2Rat210 Cardiac mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased heart weight Cardiomegaly 1303386 14640890 2 24474447 163154358 1 - by flanking markers 2 24394817 163104321 1 - by flanking markers 60999;1302795 LEW;HTG
1358902 rat Bw47 Body weight QTL 47 1 1.67 36765 D1Rat27 36592 D1Rat64 38564 D1Rat140 Body weight increased body weight Obesity 1303386 14640890 1 90282040 184857893 1 - by flanking markers 1 90360152 185007774 1 - by flanking markers 60999;1302795 LEW;HTG
1358903 rat Bp252 Blood pressure QTL 252 8 7.0 1.0E-4 36904 D8Rat19 38484 D8Rat171 37072 D8Rat59 Blood pressure post sympathetic nervous system block mean arterial blood pressure was measured in the (HTG x LEW) F2 population 5-6 month of age at baseline and after the following pharmoclogical blockades of blood pressure regulation: renin-angiotensin system block by lorsatin), sympathetic nervous system block by pentolinium), and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased systemic arterial blood pressure Hypertension 1303389 12545249 8 98451122 127956046 1 - by flanking markers 8 98470706 127976037 1 - by flanking markers 60999;1302795 LEW;HTG
1358904 rat Cm39 Cardiac mass QTL 39 2 2.26 38576 D2Rat182 36213 D2Rat40 41538 D2Rat199 Cardiac mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased heart weight Cardiomegaly 1303386 14640890 2 24474447 163154358 1 - by flanking markers 2 24394817 163104321 1 - by flanking markers 60999;1302795 LEW;HTG
1358905 rat Hrtrt17 Heart rate QTL 17 3 5.9 1.4E-5 10293 D3Mit7 34198 D3Mgh8 3632 Scn2a1 Heart rate salt-loaded after 12 weeks of dietary NaCl loading, blood pressure and heart rate were measured by femoral artery cannulation and intermittent on-line recordings. increased heart rate Heart Diseases 1358133 9286932 2958;3632 Kcnj3;Scn2a1 3 6662627 88648585 2 - by one flank and peak markers 3 6558943 88545013 2 - by one flank and peak markers 61010;61103 SHRSP;WKY
1358906 rat Bp253 Blood pressure QTL 253 8 4.0 4.0E-4 36117 D8Rat46 36904 D8Rat19 Blood pressure post sympathetic nervous system block mean arterial blood pressure was measured in the (HTG x LEW) F2 population 5-6 month of age at baseline and after the following pharmoclogical blockades of blood pressure regulation: renin-angiotensin system block by lorsatin), sympathetic nervous system block by pentolinium), and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased systemic arterial blood pressure Hypertension 1303389 12545249 8 43313902 98451660 1 - by flanking markers 8 43323018 98470858 1 - by flanking markers 60999;1302795 LEW;HTG
1358907 rat Cm40 Cardiac mass QTL 40 8 1.89 41522 D8Rat164 11222 D8Mgh3 41522 D8Rat164 Cardiac mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased heart weight Cardiomegaly 1303386 14640890 8 28414004 103684785 1 - by flanking markers 8 28414101 103704240 1 - by flanking markers 60999;1302795 LEW;HTG
1358908 rat Bw49 Body weight QTL 49 2 3.36 36213 D2Rat40 38576 D2Rat182 34005 D2Mit8 Body weight increased body weight Obesity 1303386 14640890 2 24474676 163154227 1 - by flanking markers 2 24395045 163104191 1 - by flanking markers 60999;1302795 LEW;HTG
1358909 rat Kidm25 Kidney mass QTL 25 5 1.87 37242 D5Rat77 38338 D5Rat108 60808 D5Wox25 Kidney mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) increased kidney weight Hypertension 1303386 14640890 5 94084025 134872385 2 - by one flank and peak markers 5 94089552 134877312 2 - by one flank and peak markers 60999;1302795 LEW;HTG
1358910 rat Kidm27 Kidney mass QTL 27 2 5.77 38576 D2Rat182 36213 D2Rat40 35272 D2Rat19 Kidney mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) decreased kidney weight;increased kidney weight Hypertension 1303386 14640890 2 24474447 163154358 1 - by flanking markers 2 24394817 163104321 1 - by flanking markers 60999;1302795 LEW;HTG
1358911 rat Kidm28 Kidney mass QTL 28 2 5.42 38576 D2Rat182 36213 D2Rat40 38576 D2Rat182 Kidney mass heart and kidneys were weighed and normalized per whole body weight; mean arterial blood pressure was measured at 5-6 months of age at baseline and after the following pharmacological blockades; renin-angiotensin system block by lorsatin, sympathetic nervous system block by pentolinium, and nitric oxide system block by NG-nitro-L-arginine methyl ester (L-NAME) decreased kidney weight;increased kidney weight Hypertension 1303386 14640890 2 24474447 163154358 1 - by flanking markers 2 24394817 163104321 1 - by flanking markers 60999;1302795 LEW;HTG
1354638 rat Insul1 Insulin level QTL 1 17 4.8 35176 D17Rat2 35473 D17Rat58 36329 D17Rat32 Insulin level serum genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating insulin level Metabolic Syndrome X 1302893 15452030 17 9988620 81039660 1 - by flanking markers 17 9988754 81050481 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354639 rat Spl5 Serum phospholipid level QTL 5 7 3.9 35068 D7Rat32 10880 D7Mgh22 34051 D7Mit28 Lipid level LDL phospholipid genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating LDL cholesterol level Hypertension 1302893 15452030 7 21790655 56589443 1 - by flanking markers 7 21810927 56610173 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354640 rat Scl32 Serum cholesterol level QTL 32 17 5.4 38884 D17Rat94 35585 D17Rat151 36331 D17Mit12 Lipid level HDL cholesterol genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased circulating HDL cholesterol level;abnormal circulating HDL cholesterol level Hypercholesterolemia;Metabolic Syndrome X 1302893 15452030 17 26570057 71570057 4 - by one flank marker only 17 54004828 71580890 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354641 rat Bvd2 Brain ventricular dilatation QTL 2 10 6.36 0.001 39928 D10Rat189 35254 D10Rat2 41382 D10Rat136 Head/brain development brain ventricular dilatation brain ventricular dilatation, representing inherited hydrocephalus, in 2-22 day old animals was assessed in fixed brain slices; coronal brain slices at 1.0 mm thickness were assessed for width of striatum ventricles versus width of brain to score hydrocephalus severity hydroencephaly;abnormal brain ventricle morphology Hydrocephalus 1302890 15473982 10 79981838 110718848 3 - by peak only 10 79996208 110733352 3 - by peak only 61109;68189 F344/NHsd;HTX/Hcj backcrosstoH-Tx/Hcj
1354642 rat Despr15 Despair related QTL 15 20 0.0027 3.1 35188 D20Rat1 Activity level swimming level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 61105;61109 WKY/NHsd;F344/NHsd
1354643 rat Foco2 Food consumption QTL 2 1 7.17 1.0E-4 14.4 40798 D1Rat256 Consumption level food intake food intake following adrenalectomy and treatment with RU28362 (glucocorticoid receptor agonist) was measured in male and female rats; food was provided ad libitum abnormal food intake Adrenal Gland Hypofunction 1302889 15252022 1 31371950 76371950 3 - by peak only 1 31374839 76374839 3 - by peak only 1354669;1354670 BN/OrlIcoCrlf;F344/IcoCrlf
1354644 rat Spl4 Serum phospholipid level QTL 4 7 4.9 35068 D7Rat32 39012 D7Rat98 34051 D7Mit28 Lipid level serum phospholipids genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating phospholipid level Hypertension 1302893 15452030 7 21790655 53398255 1 - by flanking markers 7 21810927 53418749 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354645 rat Swd1 Spike wave discharge measurement QTL 1 9 3.91 1.2E-4 40510 D9Rat109 41672 D9Rat163 38536 D9Rat103 Spike wave discharge measurement, type I average duration tripolar EEG electrodes were permanently implanted into F2 WAG/Rij x ACI rats and EEGs were recorded for 23 hours; the number, average and total duration of trains of SWDs were determined increased spike-wave discharge type I Epilepsy, Absence 1302436 15270755 9 100495066 101209443 1 - by flanking markers 9 100704225 101418923 1 - by flanking markers 10000;737924 ACI/N;WAG/Rij Intercross
1354646 rat Kidm18 Kidney mass QTL 18 1 5.7 38564 D1Rat140 34194 D1Mgh14 37184 D1Rat188 Kidney mass right kidney mass adjusted for body weight genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 1 154074905 263699089 1 - by flanking markers 1 154153445 263910134 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354647 rat Despr8 Despair related QTL 8 1 3.41E-5 7.3 39666 D1Rat246 Activity level climbing level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence. behavioral despair Depression 1302894 15457344 1 1 24936947 3 - by peak only 1 0 24936947 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354648 rat Bp239 Blood pressure QTL 239 2 0.001 2044 Adh1 33739 D2Mit5 Blood pressure systolic measured daily for four consecutive days by the tail cuff method on the conscious rats increased systemic arterial systolic blood pressure Hypertension 629612 9260980 2 235799396 258207540 4 - by one flank marker only 2 235786135 258222147 4 - by one flank marker only 1357190 SS.MNS-(Adh1-D2Mit5)/Mco
1354649 rat Kidm17 Kidney mass QTL 17 2 2.9 41788 D2Rat275 36081 D2Rat294 38960 D2Rat93 Kidney mass left kidney mass adjujsted for tibia length genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 2 82826122 236153712 1 - by flanking markers 2 82771084 236140274 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354650 rat Despr5 Despair related QTL 5 9 0.0017 2.9 40738 D9Rat130 Activity level immobility level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence. behavioral despair Depression 1302894 15457344 9 1 42602240 3 - by peak only 9 0 42599949 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354651 rat Lmblg2 Limb length QTL 2 17 6.0 35176 D17Rat2 35473 D17Rat58 38884 D17Rat94 Limb morphology tibia length genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal tibia morphology 1302893 15452030 17 9988620 81039660 1 - by flanking markers 17 9988754 81050481 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354652 rat Kidm20 Kidney mass QTL 20 1 4.3 37560 D1Rat155 34194 D1Mgh14 33945 D1Mit18 Kidney mass left kidney mass adjusted for body weight genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 1 181524849 263699089 1 - by flanking markers 1 181664764 263910134 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354653 rat Despr9 Despair related QTL 9 1 1.9E-4 2.7 39152 D1Rat147 Activity level climbing level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence. behavioral despair Depression 1302894 15457344 1 172723568 217723568 3 - by peak only 1 172873561 217873561 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354654 rat Spl7 Serum phospholipid level QTL 7 17 5.5 38884 D17Rat94 35585 D17Rat151 36329 D17Rat32 Lipid level serum phospholipids genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating phospholipid level Hypertension 1302893 15452030 17 26570057 71570057 4 - by one flank marker only 17 26580890 71580890 4 - by one flank marker only 10021;10022 LH/Mav;LN/Mav intercross
1354655 rat Bp241 Blood pressure QTL 241 13 3.9 41340 D13Rat116 40468 D13Rat163 41588 D13Rat128 Blood pressure systolic genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased systemic arterial systolic blood pressure;abnormal systemic arterial blood pressure Hypertension;Metabolic Syndrome X 1302893 15452030 13 37458331 105788017 1 - by flanking markers 13 37472296 105977121 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354656 rat Bvd3 Brain ventricular dilatation QTL 3 11 3.64 0.001 41256 D11Rat61 37512 D11Rat50 37942 D11Rat46 Head/brain development brain ventricular dilatation brain ventricular dilatation, representing inherited hydrocephalus, in 2-22 day old animals was assessed in fixed brain slices; coronal brain slices at 1.0 mm thickness were assessed for width of striatum ventricles versus width of brain to score hydrocephalus severity hydroencephaly;abnormal brain ventricle morphology Hydrocephalus 1302890 15473982 11 77341660 84841212 2 - by one flank and peak markers 11 77416241 84881809 2 - by one flank and peak markers 61109;68189 F344/NHsd;HTX/Hcj backcrosstoH-Tx/Hcj
1354657 rat Despr13 Despair related QTL 13 15 0.0022 2.6 36516 D15Rat1 Activity level climbing level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence. behavioral despair Depression 1302894 15457344 15 1 31488303 3 - by peak only 15 0 31488303 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354658 rat Spl8 Serum phospholipid level QTL 8 17 3.8 38884 D17Rat94 35585 D17Rat151 38772 D17Rat102 Lipid level serum phospholipids genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating VLDL cholesterol level Hypertension 1302893 15452030 17 1 71570057 2 - by one flank and peak markers 17 0 71580890 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354659 rat Spl6 Serum phospholipid level QTL 6 17 3.9 38884 D17Rat94 35585 D17Rat151 36331 D17Mit12 Lipid level VLDL genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating VLDL cholesterol level Hypertension 1302893 15452030 17 26570057 71570057 4 - by one flank marker only 17 54004828 71580890 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354660 rat Salc1 Saline consumption QTL 1 4 11.26 20.8 37592 D4Rat141 35625 D4Rat14 34943 D4Rat30 Consumption level saline intake saline (0.9%) intake was measured following adrenalectomy in male and female rats and was provided ad libitum. Saline intake following adrenalectomy and treatment with 5 micrograms/mL deoxycorticosterone (DOC), a ligand for the mineralocorticoid receptor, was also measured abnormal drinking behavior Adrenal Gland Hypofunction 1302889 15252022 4 41729771 151158666 1 - by flanking markers 4 41849418 151403508 1 - by flanking markers 1354669;1354670 BN/OrlIcoCrlf;F344/IcoCrlf
1354661 rat Bw33 Body weight QTL 33 1 5.2 38564 D1Rat140 34194 D1Mgh14 36021 D1Rat115 Body weight abnormal body weight Obesity 1302893 15452030 1 154074905 263699089 1 - by flanking markers 1 154153445 263910134 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354662 rat Rf49 Renal function QTL 49 17 2.9 38884 D17Rat94 35473 D17Rat58 38772 D17Rat102 Creatinine level serum genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating creatinine level Hypertension 1302893 15452030 17 1 81039660 2 - by one flank and peak markers 17 0 81050481 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354663 rat Bvd5 Brain ventricular dilatation QTL 5 17 3.54 0.001 33882 D17Mit2 41762 D17Rat154 41762 D17Rat154 Head/brain development brain ventricular dilatation brain ventricular dilatation, representing inherited hydrocephalus, in 2-22 day old animals was assessed in fixed brain slices; coronal brain slices at 1.0 mm thickness were assessed for width of striatum ventricles versus width of brain to score hydrocephalus severity hydroencephaly;abnormal brain ventricle morphology Hydrocephalus 1302890 15473982 17 38353858 92741217 1 - by flanking markers 17 38356700 92752050 1 - by flanking markers 61109;68189 F344/NHsd;HTX/Hcj backcrosstoH-Tx/Hcj
1354664 rat Slep2 Serum leptin concentration QTL 2 6 4.49 0.08 37142 D6Rat80 36729 D6Rat23 35390 D6Rat36 Hormone level leptin whole genome scans conducted in F2 progeny from intercrossing female OLETF, which has significantly higher leptin levels than lean controls, with male F344; serum leptin and triglyceride levels were measured via ELISA kits increased circulating leptin level Obesity 737686 14724732 dominant 6 1301952 74436995 1 - by flanking markers 6 1301953 74440121 1 - by flanking markers 61014;70509 OLETF;F344/N
1358185 rat Ept6 Estrogen-induced pituitary tumorigenesis QTL 6 3 6.7 11.0 41830 D3Rat277 34347 D3Mgh16 34186 D3Mgh9 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed. pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 3 6373454 22341164 1 - by flanking markers 3 6373754 22237536 1 - by flanking markers 737892;1358153 ACI/SegHsd;COP/CrCrl
1358186 rat Ept2 Estrogen-induced pituitary tumorigenesis QTL 2 3 8.3 35451 D3Rat21 39050 D3Rat130 35795 D3Rat26 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed. pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 3 44551542 110215186 1 - by flanking markers 3 44447914 110120760 1 - by flanking markers 737892;1358153 ACI/SegHsd;COP/CrCrl
1358187 rat Emca1 Estrogen-induced mammary cancer QTL 1 5 4.4 36275 D5Rat57 35961 D5Rat53 36187 D5Rat30 Mammary tumor susceptibility estradiol-induced time to appearance of palpable tumor following initiation of estradiol treatment mammary adenocarcinoma Breast Neoplasms 1358124;2291885 15611180;18057545 5 103677659 155120876 1 - by flanking markers 5 103682885 155130916 1 - by flanking markers 737892;1358153 ACI/SegHsd;COP/CrCrl
1358188 rat Ept9 Estrogen-induced pituitary tumorigenesis QTL 9 10 3.9 7.0 35256 D10Rat11 36203 D10Rat27 33690 D10Mit7 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed. pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 10 77092169 100633512 1 - by flanking markers 10 77106405 100648024 1 - by flanking markers 737892;1358153 ACI/SegHsd;COP/CrCrl
1358189 rat Cstrr1 Cold stress response QTL 1 1 1.0E-4 60784 D1Wox29 11359 D1Arb21 Hormone level norepinephrine Male rats were subjected to cold stress exposure of 4 degrees Celsius for 4 h every day. Arterial blood samples were taken from polyethylene catheters for measurement of plasma concentrations of catecholamines. Measurement of urinary excretion of norepinephrine (NE) and vanillymandelic acid (VMA), plasma NE levels, and blood pressure in response to cold stress is considered to be an assessment of sympathetic hyperactivity. increased circulating noradrenaline level;abnormal sensory capabilities/reflexes/nociception;increased systemic arterial blood pressure Hypertension;Stress;Autonomic Nervous System Diseases 1302892 15480093 1 124614679 187092492 1 - by flanking markers 1 124693023 187242373 1 - by flanking markers 1302636 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm
1358190 rat Ept1 Estrogen-induced pituitary tumorigenesis QTL 1 6 4.4 1357998 D6Rat150 35683 D6Rat39 37142 D6Rat80 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed. pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 6 1 8184962 2 - by one flank and peak markers 6 0 23802078 3 - by peak only 737892;1358153 ACI/SegHsd;COP/CrCrl
1358191 rat Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 1 3.8 34971 D1Rat81 37294 D1Rat133 36083 D1Rat119 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed pituitary gland hyperplasia Pituitary Neoplasms 1334449 15687265 1 235052574 250119874 2 - by one flank and peak markers 1 235224657 250380443 2 - by one flank and peak markers 737892;1358153 ACI/SegHsd;COP/CrCrl
1358192 rat Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 1 3.4 40964 D1Rat259 37688 D1Rat192 37688 D1Rat192 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed. pituitary gland hyperplasia Pituitary Neoplasms 1334449 15687265 1 23633441 77148379 1 - by flanking markers 1 23636386 77226490 1 - by flanking markers 737892;1358153 ACI/SegHsd;COP/CrCrl
1358193 rat Emca2 Estrogen-induced mammary cancer QTL 2 18 1.6 37514 D18Rat43 36548 D18Rat27 36444 D18Rat21 Mammary tumor susceptibility estradiol-induced time to appearance of palpable tumor following initiation of estradiol treatment mammary adenocarcinoma Breast Neoplasms 1358124;2291885 15611180;18057545 18 18562790 66652461 1 - by flanking markers 18 18589436 66725662 1 - by flanking markers 737892;1358153 ACI/SegHsd;COP/CrCrl
1358200 rat Insglur2 Insulin/glucose ratio QTL 2 19 4.1 41262 D19Rat57 2993 Lcat Insulin/glucose ratio insulin/glucose ratio was measured in male rats under a 60% fructose diet insulin resistance Insulin Resistance 619533 12016513 19 35784966 57234802 1 - by flanking markers 19 35789855 57239862 1 - by flanking markers 629499 BXS
1358201 rat Gluco12 Glucose level QTL12 4 1.6 35913 D4Rat10 10800 D4Wox27 10800 D4Wox27 Glucose level uptake animals were weaned at 4 weeks of age and fed a SP diet containing 5% fat, 0.4% sodium and 0.75% potassium. Blood samples were collected following a 16 hour fasting period and serum lipid concentrations were measured. For insulin-mediated glucose uptake, animals were killed around 15 weeks of age and in vitro assays on isolated adipocytes were performed. abnormal glucose absorption;abnormal glucose homeostasis Insulin Resistance 1357415 15752738 4 26280781 71280781 4 - by one flank marker only 4 460590 26296677 1 - by flanking markers 631286;631577 WKY/Izm;SHR/Izm
1358202 rat Gluco11 Glucose level QTL 11 4 2.4 0.02 35409 D4Rat34 34338 D4Mgh11 11381 D4Mgh17 Glucose level uptake animals were weaned at 4 weeks of age and fed a SP diet containing 5% fat, 0.4% sodium and 0.75% potassium. Blood samples were collected following a 16 hour fasting period and serum lipid concentrations were measured. For insulin-mediated glucose uptake, animals were killed around 15 weeks of age and in vitro assays on isolated adipocytes were performed. abnormal glucose absorption;abnormal glucose homeostasis Insulin Resistance 1357415 15752738 4 85014031 171204531 1 - by flanking markers 4 85257503 171449467 1 - by flanking markers 631286;631577 WKY/Izm;SHR/Izm
1358203 rat Stl19 Serum triglyceride level QTL 19 4 2.8 0.002 10800 D4Wox27 38728 D4Rat122 35913 D4Rat10 Lipid level triglyceride animals were weaned at 4 weeks of age and fed a SP diet containing 5% fat, 0.4% sodium and 0.75% potassium. Blood samples were collected following a 16 hour fasting period and serum lipid concentrations were measured. For insulin-mediated glucose uptake, animals were killed around 15 weeks of age and in vitro assays on isolated adipocytes were performed. increased circulating triglyceride level;increased triglyceride level Hypertriglyceridemia;Metabolic Syndrome X 1357415 15752738 4 1 64750077 2 - by one flank and peak markers 4 460492 65026207 1 - by flanking markers 631286;631577 WKY/Izm;SHR/Izm
1358204 rat Insglur1 Insulin/glucose ratio QTL 1 3 3.8 33608 D3Mit14 33927 D3Mit3 33808 D3Mit4 Insulin/glucose ratio insulin/glucose ratio was measured in male rats under a 60% fructose diet insulin resistance Insulin Resistance 619533 12016513 additive 3 115996080 136402080 1 - by flanking markers 3 115901654 136307653 1 - by flanking markers 629499 BXS
1354665 rat Stl10 Serum triglyceride level QTL 10 4 3.57 34200 D4Mgh1 35625 D4Rat14 Lipid level triglyceride whole genome scans conducted in F2 progeny from intercrossing female OLETF, which has significantly higher leptin levels than lean controls, with male F344; serum leptin and triglyceride levels were measured via ELISA kits increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 4 17617956 41729771 1 - by flanking markers 4 17617956 41849418 1 - by flanking markers 61014;70509 OLETF;F344/N
1354666 rat Bp244 Blood pressure QTL 244 13 4.9 37316 D13Rat53 40468 D13Rat163 40948 D13Rat120 Blood pressure diastolic genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased systemic arterial diastolic blood pressure;abnormal systemic arterial blood pressure Hypertension;Metabolic Syndrome X 1302893 15452030 10021;10022 LH/Mav;LN/Mav intercross
1357396 rat Bw44 Body weight QTL 44 5 4.19 34216 D5Mgh6 34041 D5Mit5 Body weight increased body weight Metabolic Syndrome X;Obesity 1357168 11374884 5 71814715 109163425 1 - by flanking markers 5 71819829 109168651 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357397 rat Bw41 Body weight QTL 41 1 4.19 1.0E-4 34662 D1Mgh2 33660 D1Mit9 33660 D1Mit9 Body weight increased body weight Obesity 1357168 11374884 1 22842898 43840628 1 - by flanking markers 1 22845906 43843573 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357398 rat Slep3 Serum leptin concentration QTL 3 8 3.43 33858 D8Mit4 33628 D8Mit6 Hormone level leptin blood samples were obtained from 28, 30 and 32 weeks old males by punturing the opthalmic venous plexus and serum leptin was determined using radio-immunoassay kit increased circulating leptin level Obesity 1357168 11374884 8 9581375 44484215 1 - by flanking markers 8 9581375 30560823 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357399 rat Bw45 Body weight QTL 45 1 3.05 11060 D1Wox23 10674 D1Mgh12 Body weight body mass index body weight of F2 male rats was determined at 32 weeks and their length measured to calculate BMI increased body weight Obesity;Metabolic Syndrome X 1357168 11374884 1 212121314 247322277 1 - by flanking markers 1 212279744 247436752 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357400 rat Bw62 Body weight QTL62 1 4.05 34662 D1Mgh2 Body fat amount adiposity index F2 male rats were weighed and killed at 32 weeks by pentobarbital injection, thier inquinal adipose pads were removed and weighed to determine the adiposity index abnormal lateral ganglionic eminence morphology Obesity 1357168 11374884 1 22842898 67842898 4 - by one flank marker only 1 22845906 67845906 4 - by one flank marker only 67935;1357345 WOKW;DA/K
1357401 rat Bw43 Body weight QTL 43 1 3.75 34662 D1Mgh2 33660 D1Mit9 Body weight increased body weight Obesity;Metabolic Syndrome X 1357168 11374884 1 22842898 43840628 1 - by flanking markers 1 22845906 43843573 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357402 rat Bw46 Body weight QTL 46 5 4.47 34216 D5Mgh6 34041 D5Mit5 Body weight body mass index body weight of F2 male rats was determined at 32 weeks and their length measured to calculate BMI increased body weight Obesity;Metabolic Syndrome X 1357168 11374884 5 71814715 109163425 1 - by flanking markers 5 71819829 109168651 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357403 rat Slep4 Serum leptin concentration QTL 4 16 3.91 33638 D16Mit4 10660 D16Mgh3 Hormone level leptin blood samples were obtained from 28, 30 and 32 weeks old females by punturing the opthalmic venous plexus and serum leptin was determined using radio-immunoassay kit increased circulating leptin level Obesity 1357168 11374884 16 9964433 30560825 1 - by flanking markers 16 9964431 30560823 1 - by flanking markers 67935;1357345 WOKW;DA/K
1357404 rat Bw42 Body weight QTL 42 1 4.49 1.0E-4 11060 D1Wox23 10674 D1Mgh12 10674 D1Mgh12 Body weight increased body weight Obesity;Metabolic Syndrome X 1357168 11374884 1 212121314 247322277 1 - by flanking markers 1 212279744 247436752 1 - by flanking markers 67935;1357345 WOKW;DA/K
1354624 rat Cm35 Cardiac mass QTL35 1 5.7 37560 D1Rat155 34194 D1Mgh14 33945 D1Mit18 Cardiac mass left ventricle adjusted for body weight genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal heart size;heart left ventricle hypertrophy Hypertrophy, Left Ventricular;Metabolic Syndrome X 1302893 15452030 1 181524849 263699089 1 - by flanking markers 1 181664764 263910134 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354625 rat Despr7 Despair related QTL 7 16 0.016 2.0 40052 D16Rat75 Activity level immobility and climbing levels rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence. behavioral despair Depression 1302894 15457344 16 1632183 46632183 3 - by peak only 16 1632155 46632155 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354626 rat Bvd1 Brain ventricular dilatation QTL 1 9 3.73 0.001 38048 D9Rat90 36325 D9Rat1 35789 D9Rat2 Head/brain development brain ventricular dilatation brain ventricular dilatation, representing inherited hydrocephalus, in 2-22 day old animals was assessed in fixed brain slices; coronal brain slices at 1.0 mm thickness were assessed for width of striatum ventricles versus width of brain to score hydrocephalus severity hydroencephaly;abnormal brain ventricle morphology Hydrocephalus 1302890 15473982 9 73454285 110864247 1 - by flanking markers 9 73601268 111073727 1 - by flanking markers 61109;68189 F344/NHsd;HTX/Hcj backcrosstoH-Tx/Hcj
1354627 rat Despr14 Despair related QTL 14 8 0.0056 2.0 37742 D8Rat163 Activity level swimming level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 8 9008612 54008612 3 - by peak only 8 9017378 54017378 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354628 rat Stl13 Serum triglyceride level QTL 13 17 3.8 38772 D17Rat102 35585 D17Rat151 36011 D17Rat17 Lipid level total triglycerides genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal triglyceride level;increased circulating VLDL cholesterol level;increased circulating triglyceride level Hypertriglyceridemia;Metabolic Syndrome X;Hypercholesterolemia 1302893 15452030 17 27118351 71570057 1 - by flanking markers 17 27121192 71580890 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354629 rat Scl31 Serum cholesterol level QTL 31 17 4.1 38884 D17Rat94 35585 D17Rat151 36329 D17Rat32 Lipid level serum cholesterol genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased circulating cholesterol level;abnormal circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome X 1302893 15452030 17 26570057 71570057 4 - by one flank marker only 17 26580890 71580890 4 - by one flank marker only 10021;10022 LH/Mav;LN/Mav intercross
1354630 rat Cm34 Cardiac mass QTL 34 17 8.7 35176 D17Rat2 35473 D17Rat58 38884 D17Rat94 Cardiac mass left ventricle genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal heart size;heart left ventricle hypertrophy Hypertrophy, Left Ventricular;Metabolic Syndrome X 1302893 15452030 17 9988620 81039660 1 - by flanking markers 17 9988754 81050481 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354631 rat Swd2 Spike wave discharge measurement QTL 2 5 3.64 2.0E-4 39168 D5Rat99 39700 D5Rat185 34206 D5Mgh15 Spike wave discharge measurement, type II total duration tripolar EEG electrodes were permanently implanted into F2 WAG/Rij x ACI rats and EEGs were recorded for 23 hours; the number, average and total duration of trains of SWDs were determined increased spike-wave discharge type II Epilepsy, Absence 1302436 15270755 5 157691737 170688737 1 - by flanking markers 5 157701777 170699258 1 - by flanking markers 10000;737924 ACI/N;WAG/Rij Intercross
1354632 rat Scl29 Serum cholesterol level QTL 29 6 3.74 35390 D6Rat36 36729 D6Rat23 11141 D6Arb12 Lipid level cholesterol whole genome scans conducted in F2 progeny from intercrossing female OLETF, which has significantly higher leptin levels than lean controls, with male F344; serum leptin and triglyceride levels were measured via ELISA kits increased circulating cholesterol level Hypercholesterolemia 737686 14724732 6 35883625 74436995 1 - by flanking markers 6 35886800 74440121 1 - by flanking markers 61014;70509 OLETF;F344/N
1354633 rat Bw28 Body weight QTL 28 19 6.04 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 Body weight post-adrenalectomy weight loss in both males and females was measured following surgical removal of adrenal glands weight loss Adrenal Gland Hypofunction 1302889 15252022 3094 Nr3c2 19 25548711 39854409 2 - by one flank and peak markers 19 25553592 39859290 2 - by one flank and peak markers 1354669;1354670 BN/OrlIcoCrlf;F344/IcoCrlf
1354634 rat Kidm12 Kidney mass QTL 12 1 3.9 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 Kidney mass right kidney mass genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 1 154074905 206567907 1 - by flanking markers 1 154153445 206721339 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354635 rat Bp245 Blood pressure QTL 245 17 6.0 38884 D17Rat94 35473 D17Rat58 36329 D17Rat32 Blood pressure mean arterial genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased systemic arterial blood pressure;abnormal systemic arterial blood pressure Hypertension;Metabolic Syndrome X 1302893 15452030 17 36039660 81039660 4 - by one flank marker only 17 36050481 81050481 4 - by one flank marker only 10021;10022 LH/Mav;LN/Mav intercross
1354636 rat Lmblg1 Limb length QTL 1 1 6.4 38564 D1Rat140 37184 D1Rat188 36105 D1Rat51 Limb morphology tibia length genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal tibia morphology 1302893 15452030 1 154074905 206567907 1 - by flanking markers 1 154153445 206721339 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354637 rat Scl30 Serum cholesterol level QTL 30 7 3.7 35068 D7Rat32 39012 D7Rat98 34051 D7Mit28 Lipid level serum cholesterol genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased circulating cholesterol level;abnormal circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome X 1302893 15452030 7 21790655 53398255 1 - by flanking markers 7 21810927 53418749 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1359017 rat Hrtrt21 Heart rate QTL 21 10 2.4 36319 D10Rat26 42373 D10Rat267 40788 D10Rat145 Heart rate stress-induced tachycardia startle reaction elicited by airpuff stimulus, which consists of acoustic and tactile components; femoral catheter attached to a pressure transducer was used to determine pulsatile and mean arterial pressure and beat-to-beat heart rate increased heart rate Heart Diseases 625381 11882571 10 68526078 101292630 2 - by one flank and peak markers 10 68540546 101307078 2 - by one flank and peak markers 61098;61099 BXH;HXB recombinantinbred
1359018 rat Hrtrt20 Heart rate QTL 20 1 3.08 41012 D1Rat287 41110 D1Rat292 36460 D1Rat69 Heart rate stress-induced tachycardia startle reaction elicited by airpuff stimulus, which consists of acoustic and tactile components; femoral catheter attached to a pressure transducer was used to determine pulsatile and mean arterial pressure and beat-to-beat heart rate increased heart rate Heart Diseases 625381 11882571 1 190114247 208110419 2 - by one flank and peak markers 1 190264129 203408013 1 - by flanking markers 61098;61099 BXH;HXB recombinantinbred
1359019 rat Hrtrt19 Heart rate QTL 19 2 2.9 35849 D2Rat62 41066 D2Rat247 36962 D2Rat63 Heart rate stress-induced early trial bradycardia startle reaction elicited by airpuff stimulus, which consists of acoustic and tactile components; femoral catheter attached to a pressure transducer was used to determine pulsatile and mean arterial pressure and beat-to-beat heart rate decreased heart rate Heart Diseases;Bradycardia 625381 11882571 2 228663949 234266109 2 - by one flank and peak markers 2 228650690 234252848 2 - by one flank and peak markers 61098;61099 BXH;HXB recombinantinbred
1359020 rat Ppulsi2 Prepulse inhibition QTL 2 18 2.71 37738 D18Rat57 35282 D18Rat5 Prepulse inhibition Rats are subjected to startle alone trials, consisting of a 120 dB white noise stimulus and 3,6, and 12 dB prepulse trials, consisting of the prepulse followed by the 120 dB pulse. Behavioral responses are monitored by a piezoelectric accelerometer abnormal prepulse inhibition Schizophrenia 629579 12426667 18 54605732 77452533 1 - by flanking markers 18 54674164 77525806 1 - by flanking markers 10008;1358112 BN/SsNHsd;WKY/NCrl
1359021 rat Bp271 Blood pressure QTL 271 8 1.8 34723 D8Mgh9 37038 D8Rat40 42849 D8Rat219 Blood pressure mean arterial femoral catheter attached to a pressure transducer was used to determine pulsatile and mean arterial pressure and beat-to-beat heart rate decreased systemic arterial blood pressure Hypertension 625381 11882571 8 27021985 49403011 2 - by one flank and peak markers 8 27024601 49417927 2 - by one flank and peak markers 61098;61099 BXH;HXB recombinantinbred
1359022 rat Ppulsi1 Prepulse inhibition QTL 1 2 3.63 36466 D2Rat34 36876 D2Rat88 Prepulse inhibition Rats are subjected to startle alone trials, consisting of a 120 dB white noise stimulus and 3,6, and 12 dB prepulse trials, consisting of the prepulse followed by the 120 dB pulse. Behavioral responses are monitored by a piezoelectric accelerometer abnormal prepulse inhibition Schizophrenia 629579 12426667 2 141755026 222281918 1 - by flanking markers 2 141705021 222268556 1 - by flanking markers 10008;1358112 BN/SsNHsd;WKY/NCrl
1359023 rat Bp272 Blood pressure QTL 272 6 2.5 37142 D6Rat80 42778 D6Rat171 37142 D6Rat80 Blood pressure mean arterial pressure, stress related changes measured change in MAP measured in response to airpuff stimulus, which consists of acoustic and tactile components; femoral catheter attached to a pressure transducer was used to determine pulsatile and mean arterial pressure and beat-to-beat heart rate decreased systemic arterial blood pressure Hypertension;Stress 625381 11882571 6 1301952 27253998 1 - by flanking markers 6 1301953 27256951 1 - by flanking markers 61098;61099 BXH;HXB recombinantinbred
1358361 rat Sradr5 Stress Responsive Adrenal Weight QTL 5 7 5.55 42215 D7Arb16 39144 D7Rat88 36731 D7Rat24 Hypothalamic-pituitary-adrenal axis adrenal gland weight adrenal glands were collected and weighed after 1 month of mild stress abnormal adrenal gland morphology 1598980 16895972 7 47145687 114883369 1 - by flanking markers 7 47165959 114917512 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1358362 rat Srcrt2 Stress Responsive Cort QTL 2 3 2.78 37510 D3Rat100 41228 D3Rat152 41162 D3Rat181 Hypothalamic-pituitary-adrenal axis corticosterone post-stress blood was taken after 10 minutes of restraint stress decreased circulating corticosterone level 1598980 16895972 3 35237920 134686096 1 - by flanking markers 3 35134293 134591669 1 - by flanking markers 61105;61109 WKY/NHsd;F344/NHsd
1358363 rat Sradr3 Stress Responsive Adrenal Weight QTL 3 4 6.19 38656 D4Rat128 Hypothalamic-pituitary-adrenal axis adrenal gland weight adrenal glands were collected and weighed after 1 month of mild stress abnormal adrenal gland morphology 1598980 16895972 4 56690161 101690161 3 - by peak only 4 56966291 101966291 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1358364 rat Sradr4 Stress Responsive Adrenal Weight QTL 4 4 4.92 39054 D4Rat137 Hypothalamic-pituitary-adrenal axis adrenal gland weight adrenal glands were collected and weighed after 1 month of mild stress abnormal adrenal gland morphology 1598980 16895972 4 132846974 177846974 3 - by peak only 4 133091815 178091815 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1358292 rat Cm37 Cardiac mass QTL 37 1 6.2 8.1E-7 17.5 36866 D1Rat73 Cardiac mass cardiac mass index At 18 weeks of age, body and heart weight were measured; cardiac mass index was calculated as grams heart weight per 100 grams body weight increased heart weight Cardiomegaly 1334448 15668357 1 201920676 246920676 3 - by peak only 1 202084699 247084699 3 - by peak only 60985;1357985 BN;LOU/Ins
1358293 rat Bw38 Body weight QTL 38 3 6.0 3.1E-6 18.6 10131 D2Wox33 Body weight decreased body weight;increased body weight 1334448 15668357 60985;1357985 BN;LOU/Ins
1358294 rat Bw37 Body weight QTL 37 1 5.0 1.1E-5 15.0 38940 D1Rat159 Body weight decreased body weight;increased body weight 1334448 15668357 1 176292515 221292515 3 - by peak only 1 176442508 221442508 3 - by peak only 60985;1357985 BN;LOU/Ins
1358295 rat Aocep1 Aortic cell protein QTL 1 17 6.1 7.1E-7 16.1 45488 D17Got80 Protein level aortic cell percentage At 18 weeks of age, body and heart weight were measured. Measurements of the thoracic aorta were taken (dry weight, cell protein, elastin and collagen contents). increased cell mass Cardiovascular Diseases 1334448 15668357 17 51995423 96995423 3 - by peak only 17 52006257 97006257 3 - by peak only 60985;1357985 BN;LOU/Ins
1358296 rat Ael3 Aortic elastin QTL 3 14 3.7 5.1E-4 9.7 38932 D14Rat36 Protein level aortic elastin At 18 weeks of age, body and heart weight were measured. Measurements of the thoracic aorta were taken (dry weight, cell protein, elastin and collagen contents) decreased aorta elastin content Cardiovascular Diseases 1334448 15668357 additive 14 10539919 55539919 3 - by peak only 14 10539875 55539875 3 - by peak only 60985;1357985 BN;LOU/Ins
1354580 rat Scort1 Serum corticosterone level QTL 1 1 3.4 36105 D1Rat51 34194 D1Mgh14 37184 D1Rat188 Hormone level corticosterone genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating corticosterone level Hypertension 1302893 15452030 1 159782445 263699089 1 - by flanking markers 1 159861463 263910134 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354581 rat Bp247 Blood pressure QTL 247 17 4.5 38884 D17Rat94 35473 D17Rat58 38772 D17Rat102 Blood pressure pulse pressure genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased pulse pressure;abnormal systemic arterial blood pressure Hypertension 1302893 15452030 17 1 81039660 2 - by one flank and peak markers 17 0 81050481 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354582 rat Stl11 Serum triglyceride level QTL 11 7 3.42 35773 D7Rat8 34393 D7Mgh20 Lipid level triglyceride whole genome scans conducted in F2 progeny from intercrossing female OLETF, which has significantly higher leptin levels than lean controls, with male F344; serum leptin and triglyceride levels were measured via ELISA kits increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 7 126748283 143002779 4 - by one flank marker only 7 126782513 143082968 4 - by one flank marker only 61014;70509 OLETF;F344/N
1354583 rat Despr3 Despair related QTL3 5 2.0E-4 3.6 37112 D5Rat40 Activity level immobility level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 61105;61109 WKY/NHsd;F344/NHsd
1354584 rat Despr6 Despair related QTL 6 16 0.0067 2.3 42022 D16Arb5 Activity level immobility level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence. behavioral despair Depression 1302894 15457344 16 1 40096603 3 - by peak only 16 0 40096601 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354585 rat Eae18a Experimental allergic encephalomyelitis QTL 18a 10 7.5 4.0E-4 11480 D10Wox13 1303359 D10Got166 1303357 D10Got165 Brain/spinal cord inflammation maximum score experimental allergic encephalomyelitis was induced by injection with myelin oligodendrocyte glycoprotein and monitored daily beginning on day 10 p.i. for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-5. paralysis Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 1302437 15240732 additive 1331824 DA.ACI-(D10Rat219-D10Rat29) Intercross
1354586 rat Despr1 Despair related QTL 1 2 0.0035 1.9 39914 D2Rat188 Activity level immobility level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 61105;61109 WKY/NHsd;F344/NHsd
1354587 rat Kidm21 Kidney mass QTL 21 10 3.3 41030 D10Rat183 36319 D10Rat26 40978 D10Rat168 Kidney mass left kidney mass adjusted for body weight genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 10 15274216 62791536 2 - by one flank and peak markers 10 15274590 62808342 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354588 rat Bvd4 Brain ventricular dilatation QTL 4 17 5.31 0.001 38464 D17Rat79 39318 D17Rat65 10348 D17Mit4 Head/brain development brain ventricular dilatation brain ventricular dilatation, representing inherited hydrocephalus, in 2-22 day old animals was assessed in fixed brain slices; coronal brain slices at 1.0 mm thickness were assessed for width of striatum ventricles versus width of brain to score hydrocephalus severity hydroencephaly;abnormal brain ventricle morphology Hydrocephalus 1302890 15473982 17 62026925 80402557 2 - by one flank and peak markers 17 62037855 93940839 1 - by flanking markers 61109;68189 F344/NHsd;HTX/Hcj backcrosstoH-Tx/Hcj
1354589 rat Bw31 Body weight QTL 31 3 3.3 38346 D3Rat98 35086 D3Rat31 35947 D3Rat45 Body weight abnormal body weight Obesity 1302893 15452030 3 30253942 76620970 1 - by flanking markers 3 30150317 76517346 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354590 rat Despr11 Despair related QTL 11 3 3.1E-5 4.8 41162 D3Rat181 Activity level climbing level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 3 25754538 70754538 3 - by peak only 3 25650877 70650877 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354591 rat Cm36 Cardiac mass QTL 36 1 4.1 35220 D1Rat29 37184 D1Rat188 38564 D1Rat140 Cardiac mass left ventricle adjusted for tibia length genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal heart size;heart left ventricle hypertrophy Hypertrophy, Left Ventricular;Metabolic Syndrome X 1302893 15452030 1 103149923 206567907 1 - by flanking markers 1 103228034 206721339 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354592 rat Rf50 Renal function QTL 50 2 3.5 36902 D2Rat270 35643 D2Rat21 33765 D2Mit35 Diuresis urine volume (24-hr) genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation polyuria Hypertension 1302893 15452030 2 53661468 75806439 1 - by flanking markers 2 53589702 75734672 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354593 rat Stl12 Serum triglyceride level QTL 12 11 3.36 34725 D11Mgh3 34118 D11Mgh2 Lipid level triglyceride whole genome scans conducted in F2 progeny from intercrossing female OLETF, which has significantly higher leptin levels than lean controls, with male F344; serum leptin and triglyceride levels were measured via ELISA kits increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 11 68234781 87759784 4 - by one flank marker only 11 68292371 87800381 4 - by one flank marker only 61014;70509 OLETF;F344/N
1354594 rat Despr10 Despair related QTL 10 2 2.49E-6 7.8 41152 D2Rat220 Activity level climbing level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 2 119504072 164504072 3 - by peak only 2 119454035 164454035 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354595 rat Despr4 Despair related QTL 4 8 0.0036 1.8 37742 D8Rat163 Activity level immobility level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 8 9008612 54008612 3 - by peak only 8 9017378 54017378 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354596 rat Bw32 Body weight QTL 32 17 4.5 35176 D17Rat2 35585 D17Rat151 38884 D17Rat94 Body weight abnormal body weight Obesity 1302893 15452030 17 9988620 71570057 1 - by flanking markers 17 9988754 71580890 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354597 rat Kidm13 Kidney mass QTL 13 3 2.9 10678 D3Mgh21 40934 D3Rat165 42139 D3Arb8 Kidney mass right kidney mass genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 3 39052756 103304908 1 - by flanking markers 3 38949128 103201336 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354598 rat Srn6 Serum renin concentration QTL 6 5 3.8 37440 D5Rat84 39478 D5Rat204 37944 D5Rat83 Renin concentration serum genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating renin level;decreased circulating renin level Metabolic Syndrome X;Kidney Diseases;Cardiovascular Diseases 1302893 15452030 5 71971592 157597184 1 - by flanking markers 5 71976706 157607223 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354599 rat Bw29 Body weight QTL 29 1 3.46 0.001 7.0 40798 D1Rat256 Body weight post-adrenalectomy weight loss in both males and females was measured following surgical removal of the adrenal glands and subsequent treatment with RU28362, a glucocorticoid receptor agonist weight loss Adrenal Gland Hypofunction 1302889 15252022 1 31371950 76371950 3 - by peak only 1 31374839 76374839 3 - by peak only 1354669;1354670 BN/OrlIcoCrlf;F344/IcoCrlf
1354600 rat Salc2 Saline consumption QTL 2 19 9.91 0.001 29.8 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 Consumption level saline intake Intake of 0.9% saline solution following adrenalectomy in male and female rats was measured abnormal drinking behavior Adrenal Gland Hypofunction 1302889 15252022 3094 Nr3c2 19 25548711 39854409 2 - by one flank and peak markers 19 25553592 39859290 2 - by one flank and peak markers 1354669;1354670 BN/OrlIcoCrlf;F344/IcoCrlf
1354601 rat Slep1 Serum leptin concentration QTL 1 2 5.39 0.065 60793 D2Wox3 34234 D2Mgh9 33850 D2Mit30 Hormone level leptin whole genome scans conducted in F2 progeny from intercrossing female OLETF, which has significantly higher leptin levels than lean controls, with male F344; serum leptin and triglyceride levels were measured via ELISA kits increased circulating leptin level Obesity 737686 14724732 dominant 2 42882523 191378271 1 - by flanking markers 2 42802970 191341025 1 - by flanking markers 61014;70509 OLETF;F344/N
1354602 rat Bw35 Body weight QTL 35 1 12.2 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 Body weight abnormal body weight Obesity 1302893 15452030 1 154074905 206567907 1 - by flanking markers 1 154153445 206721339 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354603 rat Bp243 Blood pressure QTL 243 2 3.9 38976 D2Rat124 33765 D2Mit35 36902 D2Rat270 Blood pressure diastolic genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased systemic arterial diastolic blood pressure;abnormal systemic arterial blood pressure Metabolic Syndrome X;Hypertension 1302893 15452030 2 1 131530924 2 - by one flank and peak markers 2 0 131480841 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354604 rat Bw36 Body weight QTL 36 3 2.9 38346 D3Rat98 40934 D3Rat165 42139 D3Arb8 Body weight abnormal body weight Obesity 1302893 15452030 3 30253942 103304908 1 - by flanking markers 3 30150317 103201336 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354605 rat Rf48 Renal function QTL 48 2 2.9 35643 D2Rat21 38466 D2Rat118 41300 D2Rat221 Creatinine level serum genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating creatinine level Hypertension 1302893 15452030 2 75806326 214989298 1 - by flanking markers 2 75734560 214952264 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354606 rat Bp246 Blood pressure QTL 246 1 3.6 35220 D1Rat29 33945 D1Mit18 40876 D1Rat278 Blood pressure pulse pressure genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased pulse pressure;abnormal systemic arterial blood pressure Hypertension 1302893 15452030 1 103149923 224426393 1 - by flanking markers 1 103228034 224590416 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354607 rat Gmadr1 Adrenal mass QTL 1 19 5.83 24.4 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 Gland mass adrenal adrenal gland weight was measured following surgical removal in both male and female rats small adrenal glands Adrenal Gland Hypofunction;Adrenal Gland Diseases 1302889 15252022 3094 Nr3c2 19 25548711 39854409 2 - by one flank and peak markers 19 25553592 39859290 2 - by one flank and peak markers 1354669;1354670 BN/OrlIcoCrlf;F344/IcoCrlf
1354608 rat Cm33 Cardiac mass QTL 33 10 2.8 36087 D10Rat156 34813 D10Rat16 36319 D10Rat26 Cardiac mass left ventricle genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal heart size;heart left ventricle hypertrophy Hypertrophy, Left Ventricular;Metabolic Syndrome X 1302893 15452030 10 56930545 97589703 1 - by flanking markers 10 56944071 97604073 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354609 rat Niddm62 Non-insulin dependent diabetes mellitus QTL 62 2 4.72 6.0E-6 34204 D2Mgh7 34461 D2Mgh12 35423 D2Rat41 Insulin level post-pancreatectomy glucose tolerance and glucose-induced insulin secretion tests were performed on 3 month old animals impaired glucose tolerance;increased insulin secretion;increased circulating insulin level Diabetes Mellitus, Non-Insulin-Dependent;Hyperinsulinism 1302801 15266047 62007;70972 Ensa;Hao2 2 156142685 210636169 1 - by flanking markers 2 156092649 210598923 1 - by flanking markers 10017;60985 GK/KyoSwe;BN
1354610 rat Bw34 Body weight QTL 34 1 4.1 38564 D1Rat140 34194 D1Mgh14 37184 D1Rat188 Body weight abnormal body weight Obesity 1302893 15452030 1 154074905 263699089 1 - by flanking markers 1 154153445 263910134 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354611 rat Despr2 Despair related QTL 2 3 0.0028 1.9 38318 D3Rat71 Activity level immobility level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence behavioral despair Depression 1302894 15457344 3 97595472 142595472 3 - by peak only 3 97501045 142501045 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354612 rat Foco1 Food consumption QTL 1 4 8.87 37592 D4Rat141 35625 D4Rat14 34943 D4Rat30 Consumption level food intake food intake provided ad libitum was measured in male and female rats following adrenalectomy. abnormal food intake Adrenal Gland Hypofunction 1302889 15252022 4 41729771 151158666 1 - by flanking markers 4 41849418 151403508 1 - by flanking markers 1354669;1354670 BN/OrlIcoCrlf;F344/IcoCrlf
1354613 rat Kidm14 Kidney mass QTL 14 17 6.2 35176 D17Rat2 36011 D17Rat17 38884 D17Rat94 Kidney mass left kidney mass genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 17 9988620 42344987 1 - by flanking markers 17 9988754 42347828 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354614 rat Hpcl1 Hepatic cholesterol level QTL 1 10 3.3 33909 D10Mit4 3138 Myh3 33909 D10Mit4 Lipid level cholesterol post high fat dietary liver intermediate density lipoprotein (IDL) and other lipoprotein cholesterol densities were measured in liver samples taken from rats sacrificed at 11 weeks of age following 4 weeks of feeding with a high cholesterol, high oil diet increased cholesterol level;abnormal cellular cholesterol metabolism 629576 9600105 69423 Srebf1 10 36649906 53800677 1 - by flanking markers 10 36650904 53814300 1 - by flanking markers 61098;68049 BXH;HXB-1-43
1354615 rat Cm32 Cardiac mass QTL 32 1 5.2 35220 D1Rat29 37184 D1Rat188 36105 D1Rat51 Cardiac mass left ventricle genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal heart size;heart left ventricle hypertrophy Hypertrophy, Left Ventricular;Metabolic Syndrome X 1302893 15452030 1 103149923 206567907 1 - by flanking markers 1 103228034 206721339 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354616 rat Despr12 Despair related QTL 12 6 0.0012 2.1 35963 D6Rat46 Activity level climbing level rats subjected to a forced swim test (FST) procedure in which they are placed in water for 5 min, and their behavior was scored every 5 sec as immobility, climbing, or swimming; data analyzed for each activity with consideration given to their non-independence. behavioral despair Depression 1302894 15457344 6 1 35786687 3 - by peak only 6 0 35786687 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1354617 rat Bp240 Blood pressure QTL 240 2 4.0 38976 D2Rat124 41788 D2Rat275 36902 D2Rat270 Blood pressure systolic genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased systemic arterial blood pressure;abnormal systemic arterial blood pressure Hypertension;Metabolic Syndrome X 1302893 15452030 2 24496772 82826336 2 - by one flank and peak markers 2 24408278 82771298 2 - by one flank and peak markers 10021;10022;1579897;1579900;1579904;1579905;1579908;1581620 LH/Mav;LN/Mav;SS.SR-(D9Rat69-D9Mco14)/Mco;SS.SR-(D9Rat89-Resp18)/Mco;SS.SR-(D9Mgh11-D9Mco33)/Mco;SS.SR-(D9Rat89-D9Mco27)/Mco;SS.SR-(D9Mco14-D9Rat9)/Mco;SS.SR-(D9Mco61-D9Mco27)/Mco intercross
1354618 rat Kidm15 Kidney mass QTL 15 1 5.0 36105 D1Rat51 37184 D1Rat188 40876 D1Rat278 Kidney mass left kidney mass genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 1 159782445 206567907 1 - by flanking markers 1 159861463 206721339 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354619 rat Bp242 Blood pressure QTL 242 17 6.3 38884 D17Rat94 35473 D17Rat58 37494 D17Rat98 Blood pressure systolic genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation increased systemic arterial systolic blood pressure;abnormal systemic arterial blood pressure Hypertension;Metabolic Syndrome X 1302893 15452030 17 47055924 81039660 2 - by one flank and peak markers 17 47066771 81050481 2 - by one flank and peak markers 10021;10022 LH/Mav;LN/Mav intercross
1354620 rat Kidm19 Kidney mass QTL 19 1 4.0 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 Kidney mass left kidney mass adjusted for tibia length genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 1 154074905 206567907 1 - by flanking markers 1 154153445 206721339 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354621 rat Rf47 Renal function QTL 47 13 3.7 37316 D13Rat53 40468 D13Rat163 35997 D13Rat26 Kidney renin concentration genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal circulating renin level Hypertension 1302893 15452030 10021;10022 LH/Mav;LN/Mav intercross
1354622 rat Kidm16 Kidney mass QTL 16 2 3.0 41788 D2Rat275 36962 D2Rat63 38960 D2Rat93 Kidney mass left kidney mass genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation abnormal kidney weight Hypertension 1302893 15452030 2 82826122 231465091 1 - by flanking markers 2 82771084 231451831 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1354623 rat Rf46 Renal function QTL 46 1 3.8 35220 D1Rat29 38564 D1Rat140 34922 D1Rat43 Creatinine level serum genome-wide scan on 29-31 week old male rats to determine phenotypes linked to hypertension; blood pressure was measured on conscious unrestrained males by tail cuff or via surgically implanted catheter; other traits measured after decapitation intercross abnormal circulating creatinine level Hypertension 1302893 15452030 1 103149923 154075310 1 - by flanking markers 1 103228034 154153698 1 - by flanking markers 10021;10022 LH/Mav;LN/Mav intercross
1549827 rat Scl46 Serum cholesterol level QTL 46 4 3.5 42147 D4Arb15 Lipid level baseline serum cholesterol baseline serum cholesterol was measured in blood samples from F2 rats fed standard chow increased circulating cholesterol level;regulation of floral organ abscission Hypercholesterolemia 1547851 16061941 4 135601855 180601855 3 - by peak only 4 135846791 180846791 3 - by peak only 1302711;1549801 EHC/Seac;BN/Seac
1549828 rat Bp258 Blood pressure QTL 258 2 0.03 1358052 D2Chm90 1358031 D2Chm225 Blood pressure mean arterial male rats were weaned at 21 days of age, maintained on a low salt diet and then fed a high-salt diet (2% NaCl) from 35 days of age until end of experiment. Telemetry probes were implanted at 56 days of age. increased systemic arterial blood pressure Hypertension 1357413;1599557 15738349;17143582 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd
1549829 rat Scl48 Serum cholesterol level QTL 48 12 5.0 37830 D12Rat36 Lipid level baseline serum cholesterol baseline serum cholesterol was measured in blood samples from F2 rats fed standard chow increased circulating cholesterol level;regulation of floral organ abscission Hypercholesterolemia 1547851 16061941 12 10716230 46782294 3 - by peak only 12 10579618 46649226 3 - by peak only 1302711;1549801 EHC/Seac;BN/Seac
1549830 rat Bss1 Bone structure and strength QTL 1 1 4.8 40534 D1Rat291 Bone strength Femur ultimate force in bending abnormal bone strength Bone Diseases 1549683 16059631 1 177666790 222666790 3 - by peak only 1 177816782 222816782 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1549831 rat Bss6 Bone structure and strength QTL 6 10 4.0 41170 D10Rat146 Bone strength lumbar vertebra breaking strength abnormal bone strength Bone Diseases 1549683 16059631 10 61314296 106314296 3 - by peak only 10 61328706 106328706 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1549832 rat Bss3 Bone structure and strength QTL 3 4 11.0 35070 D4Rat57 Bone structure femur midshaft cortical area and moment of inertia abnormal bone structure Bone Diseases 1549683 16059631 4 112039347 157039347 3 - by peak only 4 112284200 157284200 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1549833 rat Bp257 Blood pressure QTL 257 2 0.003 2613 Fgg 1358039 D2Chm57 Blood pressure mean arterial male rats were weaned at 21 days of age, maintained on a low salt diet and then fed a high-salt diet (2% NaCl) from 35 days of age until end of experiment. Telemetry probes were implanted at 56 days of age. increased systemic arterial blood pressure Hypertension 1357413;1599557 15738349;17143582 2 174727312 219727312 4 - by one flank marker only 2 174677417 219677417 4 - by one flank marker only 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd
1549834 rat Scl45 Serum cholesterol level QTL 45 14 5.8 41406 D14Rat88 40140 D14Rat95 38070 D14Rat43 Lipid level serum cholesterol, post dietary rats were fed a diet containing 1% cholesterol, 10% olive oil for 2 weeks, starting at 4 weeks of age; non-fasting blood samples were obtained at the end of the two week period, livers and fat pads were dissected and weighted increased circulating cholesterol level;regulation of floral organ abscission Hypercholesterolemia 1547851;2300117 16061941;18753676 14 66611911 101647208 1 - by flanking markers 14 66614302 101666284 1 - by flanking markers 1302711;1549801 EHC/Seac;BN/Seac
1549835 rat Tcas7 Tongue tumor susceptibility QTL 7 19 0.001 11472 D19Wox8 10419 D19Wox7 Tongue tumor susceptibility 4-nitroquinoline 1-oxide induced At 6 weeks of age, rats of both sexes were fed drinking water containing 0.001% 4NQO ad libitum. Rats were sacrificed when they became moribund. Number and size of keratinizing squamous cell carcinomas were measured. abnormal Deiters cell morphology Tongue Neoplasms 1358147 15876484 19 26536747 41612881 1 - by flanking markers 19 26541573 41617762 1 - by flanking markers 1358921 WF.DA-(D19Mit1-D19Mit6)/Kop
1549836 rat Bss2 Bone structure and strength QTL 2 2 7.5 34864 D2Rat67 Bone structure and strength Femur ultimate force in bending; femur midshaft cortical area and moment of inertia abnormal bone strength;abnormal bone structure Bone Diseases 1549683 16059631 2 221002002 258207540 3 - by peak only 2 220988742 258222147 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1549837 rat Hcar15 Hepatocarcinoma resistance QTL 15 1 0.05 34074 D1Mgh8 10674 D1Mgh12 36866 D1Rat73 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 4 week old male rats were allowed free access to water and rat pellets containing 0.06% 3'-Me-DAB. Rats were sacrificed at 8 weeks. Liver tissue was used for immunohistochemistry, BrdU uptake experiments and fibrosis evaluation. abnormal Rosenthal canal morphology;impaired memory in olfactory discrimination test;decreased apoptosis Carcinoma 1358145 15771619 1 156124624 247322277 1 - by flanking markers 1 156203030 247436752 1 - by flanking markers 1549849 DRH.F344-(D1Mgh8-D1Mgh12)/Kyo
1549838 rat Bss4 Bone structure and strength QTL 4 5 9.2 35060 D5Rat29 Bone structure and strength femur breaking force, stiffness, and energy to break; femur midshaft cortical area abnormal bone strength;abnormal bone structure Bone Diseases 1549683 16059631 3001 Lepr 5 113689301 158689301 3 - by peak only 5 113694527 158694527 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1549839 rat Bw52 Body weight QTL 52 4 1.0E-4 43802 D4Got41 3811 Tacr1 Body weight increased body weight Obesity 1358143 15833945 628871 Gimap5 Bw40 4 60262965 116780394 1 - by flanking markers 4 60539096 117024964 1 - by flanking markers 1357980 BB.SHR-(D4Got41-Tacr1)/K
1549840 rat Bss5 Bone structure and strength QTL 5 7 9.8 37236 D7Rat51 Bone structure femur midshaft moment of inertia abnormal bone structure Bone Diseases 1549683 16059631 7 28333735 73333735 3 - by peak only 7 28354177 73354177 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1549841 rat Bp256 Blood pressure QTL 256 2 0.03 40466 D2Rat303 1358052 D2Chm90 Blood pressure mean arterial male rats were weaned at 21 days of age, maintained on a low salt diet and then fed a high-salt diet (2% NaCl) from 35 days of age until end of experiment. Telemetry probes were implanted at 56 days of age. increased systemic arterial blood pressure Hypertension 1357413;1599557 15738349;17143582 2 131522263 176522263 4 - by one flank marker only 2 131472093 176472093 4 - by one flank marker only 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd
1549842 rat Bp248 Blood pressure QTL 248 16 0.01 36892 D16Rat12 1358042 D16Chm66 Blood pressure increased systemic arterial blood pressure Hypertension 1300037 15080379 16 350121 45350121 4 - by one flank marker only 16 350122 45350122 4 - by one flank marker only 1358168 SS.LEW-(D16Mit2-D16Chm23)/Ayd
1549843 rat Bw53 Body weight QTL 53 4 1.0E-4 43802 D4Got41 2590 Fabp1 Body weight increased body weight Obesity 1358143 15833945 628871 Gimap5 Bw40 4 60262965 104415981 1 - by flanking markers 4 60539096 104660462 1 - by flanking markers 1358922 BB.WOKW-(D4Got41-Fabp1)/K
1549844 rat Bss7 Bone structure and strength QTL 7 15 6.4 40516 D15Rat106 Bone structure femur midshaft moment of inertia abnormal bone structure Bone Diseases 1549683 16059631 15 83677810 109758846 3 - by peak only 15 83693590 109774626 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1549845 rat Scl44 Serum cholesterol level QTL 44 5 6.0 41350 D5Rat132 36275 D5Rat57 37950 D5Rat95 Lipid level serum cholesterol, post dietary rats were fed a diet containing 1% cholesterol, 10% olive oil for 2 weeks, starting at 4 weeks of age; non-fasting blood samples were obtained at the end of the two week period, livers and fat pads were dissected and weighted increased circulating cholesterol level;regulation of floral organ abscission Hypercholesterolemia 1547851 16061941 5 41498818 155121024 1 - by flanking markers 5 41499082 155131063 1 - by flanking markers 1302711;1549801 EHC/Seac;BN/Seac
1549846 rat Scl47 Serum cholesterol level QTL 47 10 3.6 36751 D10Rat25 Lipid level baseline serum cholesterol baseline serum cholesterol was measured in blood samples from F2 rats fed standard chow increased circulating cholesterol level;regulation of floral organ abscission Hypercholesterolemia 1547851 16061941 10 54091148 99091148 3 - by peak only 10 54105518 99105518 3 - by peak only 1302711;1549801 EHC/Seac;BN/Seac
1549847 rat Bss8 Bone structure and strength QTL 8 19 4.0 38432 D19Rat32 Bone strength lumbar vertebra breaking strength abnormal bone strength Bone Diseases 1549683 16059631 19 1 32421352 3 - by peak only 19 0 32426170 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd
1581497 rat Esta1 Estrogen-induced thymic atrophy QTL 1 10 0.1 36683 D10Rat42 34445 D10Mgh6 34318 D10Mgh10 Gland mass thymus 5 mg DES implants were inserted subcutaneously in rats at 63 +/-4 days of age; 12 weeks later rats were sacrificed and mass of the thymus gland, pituitary gland, and total body mass determined 1579780 16688534 incomplete_dominance 10 13754810 58754810 3 - by peak only 10 13755859 58755859 3 - by peak only 10008;737892 BN/SsNHsd;ACI/SegHsd
1581499 rat Esta2 Estrogen-induced thymic atrophy QTL 2 2 0.08 33727 D2Mit14 39240 D2Rat92 35915 D2Rat61 Gland mass thymus 5 mg DES implants were inserted subcutaneously in rats at 63 +/-4 days of age; 12 weeks later rats were sacrificed and mass of the thymus gland, pituitary gland, and total body mass determined 1579780 16688534 2 197256223 235940600 1 - by flanking markers 2 197218978 235927340 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1581500 rat Renag1 Renal agenesis QTL 1 14 36053 D14Rat4 39774 D14Rat89 Renal agenesis unilateral renal agenesis was assessed in male and female F2 rats at the completion of other studies; incidence of bilateral renal agenesis was not determined 1580355 16845468 incomplete_dominance 14 9428445 73480320 1 - by flanking markers 14 9428445 73482711 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1581502 rat Esta3 Estrogen-induced thymic atrophy QTL 3 2 0.08 36466 D2Rat34 33727 D2Mit14 36466 D2Rat34 Gland mass thymus 5 mg DES implants were inserted subcutaneously in rats at 63 +/-4 days of age; 12 weeks later rats were sacrificed and mass of the thymus gland, pituitary gland, and total body mass determined 1579780 16688534 2 141755026 197256313 1 - by flanking markers 2 141705021 197219067 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1581503 rat Cm58 Cardiac mass QTL 58 3 2.7 0.05 4.0 41780 D3Rat227 36717 D3Rat17 11261 D3Wox9 Cardiac mass left ventricle At 12 weeks of age, rats were weighed, then decapitated; spleens and hearts were collected with heart ventricles dissected into right and left ventricle and weighed seperately. LVM index was calculated by dividing the weight of LV by the whole body weight 1578726 16245027 recessive 3 41054012 121619110 1 - by flanking markers 3 40950385 121524683 1 - by flanking markers 631275;631276 WKY/Cfd;WKHA/Cfd
1581505 rat Rf54 Renal function QTL 54 5 38338 D5Rat108 36677 D5Rat31 Renal function renal production of 20-HETE male rats of chromosome 5 congenic and parental strains were fed 0.4% and 8.0% NaCl diets from weaning to 9 weeks, at which time they were assayed for multiple renal function and blood pressure related traits: mean arterial pressure, expression of CYP4A protein, CYP4A enzyme activity, proteinurea, hypertension time course, 20-HETE production and pharmocological rescue, 1578407 16396943 2479;68945;628846;631356 Cyp4a2;Cyp4a1;Cyp4a8;Cyp4a3 5 134871897 139996194 1 - by flanking markers 5 134877128 140001420 1 - by flanking markers 1579899;1579902 SS.LEW-(D5Rat130-D5Rat31)/JrMcwi;SS.LEW-(D5Rat130-D5Rat108)/JrMcwi
1581509 rat Cm57 Cardiac mass QTL 57 17 4.5 0.05 5.0 35735 D17Rat49 35827 D17Rat52 35827 D17Rat52 Cardiac mass left ventricle At 12 weeks of age, rats were weighed, then decapitated; spleens and hearts were collected with heart ventricles dissected into right and left ventricle and weighed seperately. LVM index was calculated by dividing the weight of LV by the whole body weight 1578726 16245027 67385 Cacnb2 additive 17 70094251 97296363 3 - by peak only 17 70105085 97307196 3 - by peak only 631275;631276 WKY/Cfd;WKHA/Cfd
1581510 rat Cm54 Cardiac mass QTL 54 5 3.4 0.05 4.0 35545 D5Rat28 34210 D5Mgh14 40376 D5Rat173 Cardiac mass left ventricle At 12 weeks of age, rats were weighed, then decapitated; spleens and hearts were collected with heart ventricles dissected into right and left ventricle and weighed seperately. LVM index was calculated by dividing the weight of LV by the whole body weight. 1578726 16245027 recessive 5 126963761 150236260 1 - by flanking markers 5 126968987 150246299 1 - by flanking markers 631275;631276 WKY/Cfd;WKHA/Cfd
1581512 rat Cm55 Cardiac mass QTL 55 17 2.8 0.05 5.0 34827 D17Rat12 36996 D17Rat31 34120 D17Mgh5 Cardiac mass left ventricule At 12 weeks of age, rats were weighed, then decapitated; spleens and hearts collected with heart ventricles dissected into right and left ventricle and weighed seperately. LVM index was calculated by dividing the weight of LV by the whole body weight. 1578726 16245027 additive 17 33277173 65478569 1 - by flanking markers 17 33280173 65489194 1 - by flanking markers 631275;631276 WKY/Cfd;WKHA/Cfd
1581516 rat Cm56 Cardiac mass QTL 56 12 4.2 0.05 3.0 34439 D12Mgh1 41956 D12Arb13 41956 D12Arb13 Cardiac mass left ventricle At 12 weeks of age, rats were weighed, then decapitated; spleens and hearts were collected with heart ventricles dissected into right and left ventricle and weighed seperately. LVM index was calculated by dividing the weight of LV by the whole body weight. 1578726 16245027 dominant 12 7382953 12240754 1 - by flanking markers 12 0 29912765 3 - by peak only 631275;631276 WKY/Cfd;WKHA/Cfd
1581517 rat Bp284 Blood pressure QTL 284 9 1578935 D9Mco14 3555 Resp18 Blood pressure systolic animals were fed a diet with 0.3% NaCl until 39 to 42 days of age, then switched to a 2% NaCl diet for 24 days. Tail cuff measurements of of systolic blood pressure were taken from 63 to 66 days of age. 1334447 15655120 3555 Resp18 9 29558151 74558151 4 - by one flank marker only 9 29705133 74705133 4 - by one flank marker only 1579897;1579908 SS.SR-(D9Rat69-D9Mco14)/Mco;SS.SR-(D9Mco14-D9Rat9)/Mco
1581519 rat Cm59 Cardiac mass QTL 59 15 2.8 0.05 3.0 34162 D15Mgh6 37500 D15Rat41 36149 D15Rat26 Cardiac mass left ventricle At 12 weeks of age, rats were weighed, then decapitated; spleens and hearts were collected with heart ventricles dissected into right and left ventricle and weighed seperately. LVM index was calculated by dividing the weight of LV by the whole body weight 1578726 16245027 additive 15 96375862 103677388 2 - by one flank and peak markers 15 96391642 103693168 2 - by one flank and peak markers 631275;631276 WKY/Cfd;WKHA/Cfd
1581544 rat Rf52 Renal function QTL 52 1 0.05 42282 D1Rat475 35457 D1Rat90 10674 D1Mgh12 Renal function urine protein level animals were housed in metabolic cages and urine from animals was collected after 6,12, and 18 weeks of treatment. Four treatment groups were used: 1) no treatment, 2) received chronic oral treatment with L-NAME, 3) received unilateral nephrectomy, 4) received a combination of unilateral nephrectomy and L-NAME. Systolic blood pressure was measured by the tail cuff method. 1578626 16541022 1 238613503 267111153 1 - by flanking markers 1 238777393 267322172 1 - by flanking markers 1579695;1579700 ACI.FHH-(D1Rat298-D1Rat90)/Eur;ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur
1581546 rat Pur13 Proteinuria QTL 13 3 2.93 0.0335 51.8 35356 D3Rat5 35086 D3Rat31 34411 D3Mgh14 Renal function urine protein level animals were kept in metabolic cages and monthly measurements of urinary protein excretion were taken. 1578625 16390874 3 76620970 148642985 1 - by flanking markers 3 76517346 148548894 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
1581548 rat Lftvh1 Left ventricular hypertrophy QTL 1 5 35348 D5Rat45 42770 D5Rat245 Left ventricular hypertrophy under volume overload cross sectional area surgical creation of aorto-caval fistulae (ACF) was performed and cross sectional area (CSA) of left ventricals measured in congenic and background strains as a measure of induced dilated eccentric hypertrophy and isolated diastolic dysfunction. Cardiac mass and tibia length were measured and used to normalize the CSA measures 1559301 16344368 5 159265355 173096209 4 - by one flank marker only 5 159275668 173106704 4 - by one flank marker only 1579699 WKY.WKHA-(D5Rat45-D5Rat245)/Cfd
1581550 rat Pur8 Proteinuria QTL 8 6 10361 D6Wox13 38422 D6Rat84 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 1578520 16534143 6 136451997 147636619 4 - by one flank marker only 6 136458184 147642806 4 - by one flank marker only 1579696 SS.SHR-(D6Wox13-D6Rat84)/Mco
1554317 rat Bmd4 Bone mineral density QTL 4 10 9.4 1.0E-4 35386 D10Rat8 36249 D10Rat45 36886 D10Rat32 Bone mineral density spine volumetric BMD by pQCT At 26 weeks of age, female rats were euthanized. Bone mineral density was measured as follows: spine BMD by dual-energy X-ray absorptiometry (DXA); spine volumetric BMD (vBMD) by peripheral quantitative computed tomagraphy (pQCT); spine trabecular vBMD by pQCT increased bone mineral density Osteoporosis 1553896;2316850 16180139;19841953 2161;2711;2920;3926;620677;620826;621140;621625;708568;1307023;1307496;1307522;1359691 Asgr2;Slc2a4;Irf1;Ube2i;Ltc4s;Akap1;G3bp1;Aurkb;Rabep1;Rhot1;Plxdc1;Rnps1;Fam101b 10 20233281 104013574 1 - by flanking markers 10 20234178 104027945 1 - by flanking markers 60994;60999 F344;LEW
1554318 rat Bmd5 Bone mineral density QTL 5 19 12.1 1.0E-4 35547 D19Rat25 Bone mineral density spine cortical volumetric BMD by pQCT At 26 weeks of age, female rats were euthanized. Bone mineral density was measured as follows: spine volumetric BMD (vBMD) by peripheral quantitative computed tomagraphy (pQCT); spine cortical vBMD by pQCT increased bone mineral density Osteoporosis 1553896 16180139 19 8121935 53121935 3 - by peak only 19 8126761 53126761 3 - by peak only 60994;60999 F344;LEW
1554319 rat Bmd2 Bone mineral density QTL 2 2 13.4 1.0E-4 35613 D2Rat59 38362 D2Rat161 38584 D2Rat91 Bone mineral density spine area by pQCT At 26 weeks of age, female rats were euthanized. Bone mineral density was measured as follows: femur BMD by dual-energy X-ray absorptiometry (DXA); midfemur volumetric BMD (vBMD) by peripheral quantitative computed tomagraphy (pQCT); spine area by pQCT; mid femur area by pQCT increased bone mineral density Osteoporosis 1553896 16180139 2 118264840 221131552 1 - by flanking markers 2 118209612 221118139 1 - by flanking markers 60994;60999 F344;LEW
1554320 rat Bmd1 Bone mineral density QTL 1 1 12.2 1.0E-4 41498 D1Rat266 41058 D1Rat245 38782 D1Rat136 Bone mineral density midshaft femur volumetric BMD spine area by pQCT At 26 weeks of age, female rats were euthanized. Bone mineral density was measured as follows: spinal bone mineral density by dual-energy X-ray absorptiometry (DXA); femur BMD by DXA; femur volumetric BMD (vBMD) by peripheral quantitative computed tomagraphy (pQCT); spine cortical vBMD by pQCT; spine trabecular vBMD by pQCT increased bone mineral density Osteoporosis 1553896;2293187 16180139;17907919 1 390736 74903688 2 - by one flank and peak markers 1 574288 74726026 2 - by one flank and peak markers 60994;60999 F344;LEW
1581552 rat Pur12 Proteinuria QTL 12 2 5.19 9.0E-4 34.9 37016 D2Rat30 39754 D2Rat223 37456 D2Rat147 Renal function urine protein level animals were kept in metabolic cages and monthly measurements of urinary protein excretion were taken. 1578625 16390874 2 116504240 153393151 1 - by flanking markers 2 116449203 153343178 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
1581553 rat Pur14 Proteinuria QTL 14 17 5.3 1.0E-4 36.7 37386 D17Rat76 43082 D17Rat142 38992 D17Rat61 Renal function urine protein level animals were kept in metabolic cages and monthly measurements of urinary protein excretion were taken. 1578625 16390874 17 13930240 22447143 1 - by flanking markers 17 13930241 22447143 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
1581554 rat Pur11 Proteinuria QTL 11 13 37240 D13Rat63 33923 D13Mit1 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 2314528;1578520 19176703;16534143 13 25430276 80482326 1 - by flanking markers 1579697 SS.SHR-(D13Rat63-D13Mit1)/Mco
1581555 rat Eae19 Experimental allergic encephalomyelitis QTL 19 15 4.7 34357 D15Mgh4 40106 D15Rat102 37584 D15Rat71 Brain/spinal cord inflammation severity of disease experimental allergic encephalomyelitis was induced by injection with myelin oligodendrocyte glycoprotein aa1-125 and monitored daily beginning on day 7 to day 33-40 p.i. for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-4 1549617 15716504 15 83349371 97700727 1 - by flanking markers 15 83365152 97716507 1 - by flanking markers 60997;737658 DA;PVG.1AV1
1581557 rat Eae16 Experimental allergic encephalomyelitis QTL 16 8 3.8 36097 D8Rat56 36781 D8Rat11 37324 D8Rat75 Brain/spinal cord inflammation demyelination Rats between 8 and 11 weeks of age were anesthetized with halothane and immunized intradermally in the tail base with 200ul inoculum containing 20ug of recombinant MOG (Myelin oligodendrocyte glycoprotein). From 7 to 40 days postimmunization the animals were scored for signs of EAE, histopathologically accessed for inflammation and demyelination and Anti-MOG IgG isotype was determined. 629629 12517974 recessive 8 8294860 115338082 1 - by flanking markers 8 8294861 115357537 1 - by flanking markers 737657;737658 LEW.1AV1;PVG.1AV1
1581559 rat Eae18 Experimental allergic encephalomyelitis QTL 18 10 2.0E-5 35254 D10Rat2 35228 D10Rat29 Brain/spinal cord inflammation demyelination Experimental allergic encephalomyelitis was induced by injection with myelin oligodendrocyte glycoprotein; monitored daily beginning on day 7 p.i. for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-4 1302800 11486278 10 23843272 68843272 4 - by one flank marker only 10 23856895 68856895 4 - by one flank marker only 1331816 DA.ACI-(D10Rat2-D10Rat29)
1581561 rat Eae22 Experimental allergic encephalomyelitis QTL 22 4 60421 D4Got135 Brain/spinal cord inflammation experimental allergic encephalomyelitis was induced by injection with myelin oligodendrocyte glycoprotein and monitored daily beginning on day 7 p.i. for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-5 1547849 15634914 4 145746752 187126005 3 - by peak only 4 145991688 187371129 3 - by peak only 60997;737658;737861 DA;PVG.1AV1;DA.PVG.1AV1-(D4Rat63-D4Rat203)
1581563 rat Uae33 Urinary albumin excretion QTL 33 6 10361 D6Wox13 38422 D6Rat84 Renal function urine albumin level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 1578520 16534143 6 136451997 147636619 4 - by one flank marker only 6 136458184 147642806 4 - by one flank marker only 1579696 SS.SHR-(D6Wox13-D6Rat84)/Mco
1581565 rat Pur10 Proteinuria QTL 10 11 1.0E-4 34725 D11Mgh3 35633 D11Rat31 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 1578520 16534143 11 8176422 68234781 1 - by flanking markers 11 8176422 68292371 1 - by flanking markers 1579691 SS.SHR-(D11Mgh3-D11Rat31)/Mco
1581566 rat Eae21 Experimental allergic encephalomyelitis QTL 21 4 6.2 43012 D14Rat113 60419 D4Got132 60418 D4Got131 Brain/spinal cord inflammation change in body weight experimental allergic encephalomyelitis was induced by injection with myelin oligodendrocyte glycoprotein and monitored daily beginning on day 7 p.i. for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-5 1547849 15634914 4 162206044 162362144 2 - by one flank and peak markers 4 162450980 162607080 2 - by one flank and peak markers 60997;737658 DA;PVG.1AV1
1581568 rat Rf53 Renal function QTL 53 3 38686 D3Rat84 36759 D3Rat59 33808 D3Mit4 Renal function urine protein level animals were housed in metabolic cages and urine from animals was collected after 6,12, and 18 weeks of treatment. Four treatment groups were used: 1) no treatment, 2) received chronic oral treatment with L-NAME, 3) received unilateral nephrectomy, 4) received a combination of unilateral nephrectomy and L-NAME. Systolic blood pressure was measured by the tail cuff method. 1578626 16541022 3 53876762 163443738 1 - by flanking markers 3 53773134 163349774 1 - by flanking markers 1579678;1579700 ACI.FHH-(D3Wox2-D3Rat59)/Eur;ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur
1581569 rat Uae32 Urinary albumin excretion QTL 32 2 1.0E-4 35915 D2Rat61 66661 D2Mco18 Renal function urine albumin level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 1625111;1578520 17504948;16534143 2 79796977 227150051 1 - by flanking markers 2 79741939 227136731 1 - by flanking markers 1579703 SS.SHR-(D2Rat61-D2Mco18)/Mco
1581570 rat Eae17 Experimental allergic encephalomyelitis QTL 17 13 4.1 39436 D13Rat142 37180 D13Rat64 34833 D13Rat19 Brain/spinal cord inflammation demyelination Rats between 8 and 11 weeks of age were anesthetized with halothane and immunized intradermally in the tail base with 200ul inoculum containing 20ug of recombinant MOG (Myelin oligodendrocyte glycoprotein). From 7 to 40 days postimmunization the animals were scored for signs of EAE, histopathologically accessed for inflammation and demyelination and Anti-MOG IgG isotype was determined. 629629 12517974 dominant 13 28645448 106366082 1 - by flanking markers 13 28648272 106555186 1 - by flanking markers 737657;737658 LEW.1AV1;PVG.1AV1
1581571 rat Pur9 Proteinuria QTL 9 9 38270 D9Rat97 37416 D9Rat70 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. 1578520 16534143 9 1 21667255 4 - by one flank marker only 9 0 21668669 4 - by one flank marker only 1579702 SS.SHR-(D9Wox16-D9Rat64)/Mco
1581572 rat Uae35 Urinary albumin excretion QTL 35 11 1.0E-4 34725 D11Mgh3 35633 D11Rat31 Renal function urine albumin level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 1578520 16534143 11 8176422 68234781 1 - by flanking markers 11 8176422 68292371 1 - by flanking markers 1579691 SS.SHR-(D11Mgh3-D11Rat31)/Mco
1581573 rat Uae36 Urinary albumin excretion QTL 36 13 37240 D13Rat63 33923 D13Mit1 Renal function urine albumin level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 2314528;1578520 19176703;16534143 13 25430276 80482326 1 - by flanking markers 1579697 SS.SHR-(D13Rat63-D13Mit1)/Mco
1581574 rat Eae20 Experimental allergic encephalomyelitis QTL 20 4 7.8 43012 D14Rat113 60419 D4Got132 34473 D4Mgh10 Brain/spinal cord inflammation disease incidence Experimental allergic encephalomyelitis was induced by injection with myelin oligodendrocyte glycoprotein; monitored daily beginning on day 7 p.i. for changes in weight and for clinical signs of paresis/paralysis which were scored on a scale from 0-5 1547849 15634914 4 155974180 162362144 2 - by one flank and peak markers 4 156219116 162607080 2 - by one flank and peak markers 60997;737658 DA;PVG.1AV1
1581576 rat Pur7 Proteinuria QTL 7 2 1.0E-4 35915 D2Rat61 66661 D2Mco18 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 1578520 16534143 2 79796977 227150051 1 - by flanking markers 2 79741939 227136731 1 - by flanking markers 1579703 SS.SHR-(D2Rat61-D2Mco18)/Mco
1581577 rat Pur15 Proteinuria QTL 15 20 4.38 2.0E-4 23.6 37632 D20Rat49 35657 D20Rat5 34872 D20Rat3 Renal function urine protein level animals were kept in metabolic cages and monthly measurements of urinary protein excretion were taken. 1578625 16390874 20 8286533 18411969 1 - by flanking markers 20 8286761 18426179 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
1581578 rat Cm49 Cardiac mass QTL 49 2 4.9 0.01 34005 D2Mit8 35915 D2Rat61 34497 D2Mgh24 Cardiac mass left ventricle animals were analyzed for relative left ventricular mass which equals ventricular mass divided by body weight 1578627 16286240 2609;61973;621276;628721;631398 Fgf2;Trpc3;Trpc4;Sclt1;Kcnmb2 2 148790600 227150248 1 - by flanking markers 2 148740564 227136928 1 - by flanking markers 60994;1302620 F344;SHR/Kyo
1581580 rat Uae34 Urinary albumin excretion QTL 34 9 38270 D9Rat97 37416 D9Rat70 Renal function urine albumin level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Blood pressure was measured and urine collected to measure urinary protein excretion and urinary albumin excretion 1578520 16534143 9 1 21667255 4 - by one flank marker only 9 0 21668669 4 - by one flank marker only 1579702 SS.SHR-(D9Wox16-D9Rat64)/Mco
1554321 rat Bmd3 Bone mineral density QTL 3 8 7.9 1.0E-4 36934 D8Rat10 37580 D8Rat99 35018 D8Rat15 Bone mineral density distal femur volumetric BMD by pQCT At 26 weeks of age, female rats were euthanized. Bone mineral density was measured as follows: distal femur volumetric BMD (vBMD) by peripheral quantitative computed tomagraphy (pQCT); femur BMD by dual-energy X-ray absorptiometry (DXA); spine BMD by DXA increased bone mineral density Osteoporosis 1553896 16180139 8 43561064 129041809 2 - by one flank and peak markers 8 43569831 129061546 2 - by one flank and peak markers 60994;60999 F344;LEW
1582216 rat Bw65 Body weight QTL 65 3 6.3 19.0 41296 D3Rat166 42664 D3Rat257 41296 D3Rat166 Body weight genome wide linkage analysis of 6 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 3 101359810 116023640 1 - by flanking markers 3 101256089 115929213 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582218 rat Bw74 Body weight QTL 74 3 3.9 0.0021 13.0 34146 D3Mgh6 42664 D3Rat257 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Metabolic Syndrome X;Obesity 1580752 15728334 3 50522618 116023640 1 - by flanking markers 3 50418991 115929213 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582219 rat Bw63 Body weight QTL 63 3 3.8 0.001 12.0 38328 D3Rat81 42664 D3Rat257 41296 D3Rat166 Body weight genome wide linkage analysis of 2 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 3 86696150 116023640 2 - by one flank and peak markers 3 86583319 115929213 2 - by one flank and peak markers 728161;737899 PD/Cub;BN/Cub intercross
1582221 rat Kidm30 Kidney mass QTL 30 3 3.5 8.0E-4 12.0 35589 D3Rat37 42664 D3Rat257 41296 D3Rat166 Kidney mass genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased kidney weight Metabolic Syndrome X 1580752 15728334 3 62558027 116023640 1 - by flanking markers 3 62454399 115929213 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582222 rat Epfw2 Epididymal fat weight QTL 2 8 3.2 5.0E-4 14.0 36161 D8Rat36 Epididymal fat weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome abnormal abdominal fat pad morphology Metabolic Syndrome X 1580752 15728334 8 34808657 79808657 3 - by peak only 8 34827711 79827711 3 - by peak only 728161;737899 PD/Cub;BN/Cub intercross
1556747 rat Calcic1 Intracellular calcium level QTL 1 12 3.6 19.8 34729 D12Mgh5 34373 D12Mgh6 2174 Atp2a2 Intracellular calcium level thrombin-stimulated thrombin-stimulated calcium ion concentration was measured in Ca2+ free and Ca2+ containing buffers in platelets using Fura-2 Hypertension 1547855 15882549 2174 Atp2a2 12 29130180 41452656 2 - by one flank and peak markers 12 28993569 41316001 2 - by one flank and peak markers 631604;1556748 SHR/Snk;F344/Snk
1576302 rat Schws4 Schwannoma susceptibility QTL 4 6 0.0078 33662 D6Mit1 Neural tumor susceptibility tumor incidence, length of survival time genome wide scan for loci mediating susceptibility to ethylnitrosourea (EtNU)-induced malignant schwannomas; rats were given a single subcutaneous injection of EtNU (80 microg/g bodyweight) and screened for neurological symptoms from 10 wks after exposure; rats exhibiting visible tumors, cachexia, shortness of breath, paralysis, or other behavioral abnormalities were killed and tumors removed and frozen increased incidence of induced tumors Neurilemmoma 1559300 16003739 6 76340580 121340580 3 - by peak only 6 76344036 121344036 3 - by peak only 1566454;1566456 BDIV/Zte;BDIX/Zte
1576303 rat Ept7 Estrogen-induced pituitary tumorigenesis QTL 7 7 3.7 34999 D7Rat44 36661 D7Rat15 35841 D7Rat19 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed. pituitary gland hyperplasia Pituitary Neoplasms 1642526 17876666 3130;3904;621120 Myc;Trhr;Cdk4 recessive 7 66201980 107428439 1 - by flanking markers 7 66222710 107462669 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1576304 rat Schws7 Schwannoma susceptibility QTL 7 10 0.0115 34254 D10Mgh12 Neural tumor susceptibility tumor incidence genome wide scan for loci mediating susceptibility to ethylnitrosourea (EtNU)-induced malignant schwannomas; rats were given a single subcutaneous injection of EtNU (80 microg/g bodyweight) and screened for neurological symptoms from 10 wks after exposure; rats exhibiting visible tumors, cachexia, shortness of breath, paralysis, or other behavioral abnormalities were killed and tumors removed and frozen increased incidence of induced tumors Neurilemmoma 1559300 16003739 10 1 41641939 3 - by peak only 10 0 41642988 3 - by peak only 1566454;1566456 BDIV/Zte;BDIX/Zte
1576305 rat Emca6 Estrogen-induced mammary cancer QTL 6 4 5.8 35625 D4Rat14 40322 D4Rat202 38262 D4Rat103 Mammary tumor susceptibility estradiol-induced time to appearance of palpable mammary tumor following treatment with estradiol mammary adenocarcinoma Breast Neoplasms 1642522;2291885 16885383;18057545 recessive 4 41729583 123672029 2 - by one flank and peak markers 4 41849231 124121625 2 - by one flank and peak markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1576306 rat Schws3 Schwannoma susceptibility QTL 3 3 0.001 33810 D3Mit2 Neural tumor susceptibility tumor incidence genome wide scan for loci mediating susceptibility to ethylnitrosourea (EtNU)-induced malignant schwannomas; rats were given a single subcutaneous injection of EtNU (80 microg/g bodyweight) and screened for neurological symptoms from 10 wks after exposure; rats exhibiting visible tumors, cachexia, shortness of breath, paralysis, or other behavioral abnormalities were killed and tumors removed and frozen increased incidence of induced tumors Neurilemmoma 1559300 16003739 3 120620299 165620299 3 - by peak only 1566454;1566456 BDIV/Zte;BDIX/Zte
1576307 rat Cia28 Collagen induced arthritis QTL 28 10 35256 D10Rat11 61275 D10Arb22 Joint/bone inflammation type II collagen-induced eight to twelve week old animals were injected transdermally with bovine type II collagen for 7 days; animals were evaluated for arthritis severity by scoring synovial inflammation, synovial hyperplasia, extension of pannus formation, synovial fibrosis, synovial vascularity, cartilage erosion, cartilage degradation and bone erosion 1359065;1642451;2307198 15944295;17673937;18540828 10 100633512 110718848 4 - by one flank marker only 10 100648024 110733352 4 - by one flank marker only 1299877 DA.F344-(D10Rat204-D10Arb22)/Arb
1576308 rat Schws1 Schwannoma susceptibility QTL 1 10 0.0041 34274 D10Mgh5 Neural tumor susceptibility tumor incidence, length of survival time genome wide scan for loci mediating susceptibility to ethylnitrosourea (EtNU)-induced malignant schwannomas; rats were given a single subcutaneous injection of EtNU (80 microg/g bodyweight) and screened for neurological symptoms from 10 wks after exposure; rats exhibiting visible tumors, cachexia, shortness of breath, paralysis, or other behavioral abnormalities were killed and tumors removed and frozen increased incidence of induced tumors Neurilemmoma 1559300 16003739 10 63816942 108816942 3 - by peak only 10 63831313 108831313 3 - by peak only 1566454;1566456 BDIV/Zte;BDIX/Zte
1576309 rat Emca7 Estrogen-induced mammary cancer QTL 7 6 4.0 39190 D6Rat68 38390 D6Rat81 35140 D6Rat22 Mammary tumor susceptibility estradiol-induced time to appearance of palpable mammary tumor following treatment with estradiol mammary adenocarcinoma Breast Neoplasms 1642522;2291885 16885383;18057545 dominant 6 2802670 111967837 1 - by flanking markers 6 2802670 111971368 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1576310 rat Schws2 Schwannoma susceptibility QTL 2 1 0.029 33646 D1Mit4 Neural tumor susceptibility tumor incidence, length of survival time genome wide scan for loci mediating susceptibility to ethylnitrosourea (EtNU)-induced malignant schwannomas; rats were given a single subcutaneous injection of EtNU (80 microg/g bodyweight) and screened for neurological symptoms from 10 wks after exposure; rats exhibiting visible tumors, cachexia, shortness of breath, paralysis, or other behavioral abnormalities were killed and tumors removed and frozen increased incidence of induced tumors Neurilemmoma 1559300 16003739 1566454;1566456 BDIV/Zte;BDIX/Zte
1576311 rat Pia26 Pristane induced arthritis QTL 26 10 36496 D10Rat37 36751 D10Rat25 Joint/bone inflammation pristane induced eight to twelve week old animals were injected intradermally with 150 ul of pristane; animals were evaluated for arthritis severity by scoring synovial inflammation, synovial hyperplasia, extension of pannus formation, synovial fibrosis, synovial vascularity, cartilage erosion, cartilage degradation and bone erosion joint swelling Arthritis, Rheumatoid 1359065;2300006;2302383;1358860;2307198 15944295;18706093;18668563;15641042;18540828 3612;3965;1307740;1308885;1309749 Ncor1;Trpv2;Gtlf3b;Trim41;Trim16 10 35131252 76591208 1 - by flanking markers 10 35132481 76605578 1 - by flanking markers 1358990 DA.F344-(D10Rat37-D10Arb9)/Nsi
1576312 rat Emca8 Estrogen-induced mammary cancer QTL 8 5 4.1 39722 D5Rat134 35651 D5Rat37 37950 D5Rat95 Mammary tumor susceptibility estradiol-induced time to appearance of palpable mammary tumor following treatment with estradiol mammary adenocarcinoma Breast Neoplasms 1642522;2291885 16885383;18057545 dominant 5 52434178 148460381 1 - by flanking markers 5 52434357 148470420 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1576313 rat Pia25 Pristane induced arthritis QTL 25 10 35256 D10Rat11 61275 D10Arb22 Joint/bone inflammation pristane induced eight to twelve week old animals were injected intradermally with 150 ul of pristane; animals were evaluated for arthritis severity by scoring synovial inflammation, synovial hyperplasia, extension of pannus formation, synovial fibrosis, synovial vascularity, cartilage erosion, cartilage degradation and bone erosion 1359065 15944295 10 100633512 110718848 4 - by one flank marker only 10 100648024 110733352 4 - by one flank marker only 1299877 DA.F344-(D10Rat204-D10Arb22)/Arb
1576314 rat Eutr1 Estrogen induced uterine response QTL 1 5 38744 D5Rat116 36811 D5Rat16 36558 D5Rat19 Uterine inflammation estrogen-induced susceptibility to estrogen induced uterine inflammation and pyometritis was assessed by macroscopic evaluation of dissected uteri and use of a scoring system for pyometritis severity; implants containing 27.5 mg E2 were inserted subcutaneously into rats at approx. age 64 days and rats were sacrificed after 139-196 days of treatment reproductive system inflammation Bacterial Infections;Inflammation 1559292 16284801 incomplete_dominance 5 1220773 79863911 1 - by flanking markers 5 1220773 79869024 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1576315 rat Schws6 Schwannoma susceptibility QTL 6 15 0.0069 34357 D15Mgh4 Neural tumor susceptibility length of survival time genome wide scan for loci mediating susceptibility to ethylnitrosourea (EtNU)-induced malignant schwannomas; rats were given a single subcutaneous injection of EtNU (80 ug/g bodyweight) and screened for neurological symptoms from 10 wks after exposure; rats exhibiting visible tumors, cachexia, shortness of breath, paralysis, or other behavioral abnormalities were killed and tumors removed and frozen increased incidence of induced tumors Neurilemmoma 1559300 16003739 15 60849424 105849424 3 - by peak only 15 60865204 105865204 3 - by peak only 1566454;1566456 BDIV/Zte;BDIX/Zte
1576316 rat Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 4 3.8 38262 D4Rat103 39414 D4Rat204 34174 D4Mgh7 Gland mass pituitary Pituitary mass at 12 weeks following subcutaneous estrogen treatment; animals were decapitated and the pituitary gland was immediately removed and weighed. pituitary gland hyperplasia Pituitary Neoplasms 1642526 17876666 2688;3556;3849;3903;69062;621083;632283 Ghrhr;Ret;Tgfa;Trh;Cdkn1b;Ccnd2;Ghrl dominant 4 82700691 182307104 1 - by flanking markers 4 82985313 182552228 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1576317 rat Eutr2 Estrogen induced uterine response QTL 2 5 0.01 36113 D5Rat1 34041 D5Mit5 Uterine inflammation estrogen-induced susceptibility to DES-induced uterine inflammation and pyometritis was assessed by macroscopic evaluation of dissected uteri and use of scoring system for pyometritis severity; implants containing 5 mg DES were inserted subcutaneously into rats at around 21 days of age, rats were sacrificed after 10 weeks of treatment reproductive system inflammation Inflammation;Bacterial Infections 1559291 16284802 5 35911094 109163425 1 - by flanking markers 5 35911273 109168651 1 - by flanking markers 1331830 F344.BN-(D5Rat1-D5Mit5)/Dlw
1576318 rat Schws5 Schwannoma susceptibility QTL 5 13 0.0351 42383 D13Rat191 Neural tumor susceptibility tumor incidence, length of survival time genome wide scan for loci mediating susceptibility to ethylnitrosourea (EtNU)-induced malignant schwannomas; rats were given a single subcutaneous injection of EtNU (80 microg/g bodyweight) and screened for neurological symptoms from 10 wks after exposure; rats exhibiting visible tumors, cachexia, shortness of breath, paralysis, or other behavioral abnormalities were killed and tumors removed and frozen increased incidence of induced tumors Neurilemmoma 1559300 16003739 13 65464406 110464406 3 - by peak only 13 65653194 110653194 3 - by peak only 1566454;1566456 BDIV/Zte;BDIX/Zte
1576319 rat Cia29 Collagen induced arthritis QTL 29 10 36496 D10Rat37 10641 D10Wox22 Joint/bone inflammation type II collagen-induced eight to twelve week old animals were injected transdermally with bovine type II collagen for 7 days and then animals were evaluated for arthritis severity 1359065 15944295 10 35131252 95695218 1 - by flanking markers 10 35132481 80132481 4 - by one flank marker only 1359004 DA.F344-(D10Rat37-D10Wox22)/Nsi
1582212 rat Livw2 Liver weight QTL 2 5 3.5 4.0E-4 12.0 38512 D5Rat80 39952 D5Rat158 60808 D5Wox25 Liver weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased liver weight Metabolic Syndrome X 1580752 15728334 5 103701215 125255195 2 - by one flank and peak markers 5 103706178 125260686 2 - by one flank and peak markers 728161;737899 PD/Cub;BN/Cub intercross
1582213 rat Insul6 Insulin level QTL 6 3 3.7 9.0E-4 13.0 38236 D3Rat213 41132 D3Rat143 41132 D3Rat143 Insulin level genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating insulin level Hyperinsulinism;Metabolic Syndrome X 1580752 15728334 728161;737899 PD/Cub;BN/Cub intercross
1582214 rat Stl21 Serum triglyceride level QTL 21 15 3.1 0.022 11.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 Lipid level triglyceride genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating triglyceride level Metabolic Syndrome X 1580752 15728334 15 32638412 89569864 1 - by flanking markers 15 32654112 89585644 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582224 rat Epfw4 Epididymal fat weight QTL 4 17 3.5 0.0058 12.0 40956 D17Rat107 38706 D17Rat84 40956 D17Rat107 Epididymal fat weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome abnormal abdominal fat pad morphology Metabolic Syndrome X 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582225 rat Bw67 Body weight QTL 67 17 6.2 1.0E-4 19.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 Body weight genome wide linkage analysis of 6 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582226 rat Bw64 Body weight QTL 64 17 4.2 0.0017 13.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 Body weight genome wide linkage analysis of 2 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582227 rat Gluco30 Glucose level QTL 30 15 3.6 3.0E-4 13.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 15 32638412 89569864 1 - by flanking markers 15 32654112 89585644 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582228 rat Epfw3 Epididymal fat weight QTL 3 15 4.1 2.0E-4 14.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 Epididymal fat weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome abnormal abdominal fat pad morphology Metabolic Syndrome X 1580752 15728334 15 32638412 89569864 1 - by flanking markers 15 32654112 89585644 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582229 rat Stl20 Serum triglyceride level QTL 20 8 3.2 0.0033 14.0 36872 D8Rat43 44411 D8Got72 36872 D8Rat43 Lipid level triglyceride genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating triglyceride level Metabolic Syndrome X 1580752 15728334 8 51577566 52065790 1 - by flanking markers 8 51596621 52084844 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582230 rat Bw78 Body weight QTL 78 5 3.2 0.0016 11.0 39952 D5Rat158 38338 D5Rat108 10454 D5Wox12 Body fat amount adiposity index genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome abnormal lateral ganglionic eminence morphology Metabolic Syndrome X;Obesity 1580752 15728334 5 125254995 134872385 1 - by flanking markers 5 125260177 134877312 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582232 rat Gluco25 Glucose level QTL 25 4 3.6 0.0023 16.0 35721 D4Rat76 37592 D4Rat141 37592 D4Rat141 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 4 84886545 151158853 1 - by flanking markers 4 85130017 151403694 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582233 rat Insul10 Insulin level QTL 10 3 5.4 0.0015 18.0 38236 D3Rat213 41132 D3Rat143 38236 D3Rat213 Insulin level genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating insulin level Metabolic Syndrome X;Hyperinsulinism 1580752 15728334 728161;737899 PD/Cub;BN/Cub intercross
1582234 rat Gluco18 Glucose level QTL 18 1 3.4 3.0E-4 12.0 39320 D1Rat220 36432 D1Rat35 39320 D1Rat220 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 1 79749065 124749065 4 - by one flank marker only 1 79827408 124827408 4 - by one flank marker only 728161;737899 PD/Cub;BN/Cub intercross
1582235 rat Insul8 Insulin level QTL 8 16 3.3 0.0063 15.0 33848 D16Mit2 33652 D16Mit5 33848 D16Mit2 Insulin level genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating insulin level Hyperinsulinism;Metabolic Syndrome X 1580752 15728334 16 1 26804456 3 - by peak only 16 0 26804454 3 - by peak only 728161;737899 PD/Cub;BN/Cub intercross
1582236 rat Gluco22 Glucose level QTL 22 14 3.3 0.0164 15.0 41986 D14Arb10 39030 D14Rat38 41986 D14Arb10 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 14 54080020 99080020 4 - by one flank marker only 14 54099165 99099165 4 - by one flank marker only 728161;737899 PD/Cub;BN/Cub intercross
1582237 rat Kidm34 Kidney mass QTL 34 4 4.0 1.0E-4 19.0 37592 D4Rat141 36486 D4Rat68 10049 D4Wox16 Kidney mass genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased kidney weight Metabolic Syndrome X 1580752 15728334 4 151158666 172169650 1 - by flanking markers 4 151403508 172414586 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582238 rat Bw68 Body weight QTL 68 3 3.2 0.0064 11.0 34146 D3Mgh6 42664 D3Rat257 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 3 50522618 116023640 1 - by flanking markers 3 50418991 115929213 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582239 rat Epfw1 Epididymal fat weight QTL 1 3 4.5 6.0E-4 16.0 34146 D3Mgh6 42664 D3Rat257 Epididymal fat weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome abnormal abdominal fat pad morphology Metabolic Syndrome X 1580752 15728334 3 50522618 116023640 1 - by flanking markers 3 50418991 115929213 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582240 rat Sffal1 Serum free fatty acids level QTL 1 7 3.4 0.0021 12.0 38306 D7Rat97 35681 D7Rat5 35681 D7Rat5 Lipid level free fatty acids genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome 1580752 15728334 7 123574473 131350792 1 - by flanking markers 7 123608732 131427229 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582241 rat Bw70 Body weight QTL 70 17 4.6 3.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582242 rat Gluco28 Glucose level QTL 28 15 3.3 8.0E-4 11.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 15 32638412 89569864 1 - by flanking markers 15 32654112 89585644 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582243 rat Bw66 Body weight QTL 66 8 3.4 0.0048 15.0 36161 D8Rat36 37324 D8Rat75 36161 D8Rat36 Body weight genome wide linkage analysis of 6 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 8 57308572 89558994 1 - by flanking markers 8 57327627 89578449 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582244 rat Bw79 Body weight QTL 79 15 4.0 2.0E-4 14.0 35120 D15Rat6 34409 D15Mgh9 Body fat amount adiposity index genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome abnormal lateral ganglionic eminence morphology Metabolic Syndrome X;Obesity 1580752 15728334 15 32638412 89569864 1 - by flanking markers 15 32654112 89585644 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582245 rat Bw73 Body weight QTL 73 17 4.6 4.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Metabolic Syndrome X;Obesity 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582246 rat Cm60 Cardiac mass QTL 60 2 5.8 24.0 35272 D2Rat19 33620 D2Mit6 35272 D2Rat19 Cardiac mass genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased heart weight Metabolic Syndrome X;Cardiomegaly 1580752 15728334 2 35617521 80617521 3 - by peak only 2 58045691 77562125 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582248 rat Insul7 Insulin level QTL 7 3 3.9 0.0041 14.0 41132 D3Rat143 Insulin level genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating insulin level Hyperinsulinism;Metabolic Syndrome X 1580752 15728334 728161;737899 PD/Cub;BN/Cub intercross
1582249 rat Bw77 Body weight QTL 77 3 3.2 0.0025 12.0 34146 D3Mgh6 35589 D3Rat37 34146 D3Mgh6 Body fat amount adiposity index genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome abnormal lateral ganglionic eminence morphology Metabolic Syndrome X;Obesity 1580752 15728334 3 50522618 62558206 1 - by flanking markers 3 50418991 62454578 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582250 rat Gluco26 Glucose level QTL 26 14 3.3 9.0E-4 15.0 41986 D14Arb10 35897 D14Rat22 39030 D14Rat38 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 14 95650437 102509397 2 - by one flank and peak markers 14 95669516 102528608 2 - by one flank and peak markers 728161;737899 PD/Cub;BN/Cub intercross
1582251 rat Gluco24 Glucose level QTL 24 15 3.2 8.0E-4 11.0 35120 D15Rat6 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 15 10138595 55138595 3 - by peak only 15 10154295 55154295 3 - by peak only 728161;737899 PD/Cub;BN/Cub intercross
1582252 rat Sual1 Serum uric acid level QTL 1 3 3.4 0.0123 12.0 38328 D3Rat81 41296 D3Rat166 38328 D3Rat81 Serum uric acid level genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome Metabolic Syndrome X 1580752 15728334 3 56359980 101359980 4 - by one flank marker only 3 56256444 101256444 4 - by one flank marker only 728161;737899 PD/Cub;BN/Cub intercross
1582254 rat Kidm31 Kidney mass QTL 31 8 36161 D8Rat36 37324 D8Rat75 36161 D8Rat36 Kidney mass genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased kidney weight Metabolic Syndrome X 1580752 15728334 8 57308572 89558994 1 - by flanking markers 8 57327627 89578449 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582255 rat Gluco29 Glucose level QTL 29 14 3.1 0.0025 14.0 41986 D14Arb10 39030 D14Rat38 41986 D14Arb10 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 14 54080020 99080020 4 - by one flank marker only 14 54099165 99099165 4 - by one flank marker only 728161;737899 PD/Cub;BN/Cub intercross
1582256 rat Insul9 Insulin level QTL 9 3 4.4 0.0016 15.0 38236 D3Rat213 41132 D3Rat143 41132 D3Rat143 Insulin level genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating insulin level Metabolic Syndrome X;Hyperinsulinism 1580752 15728334 728161;737899 PD/Cub;BN/Cub intercross
1582257 rat Gluco21 Glucose level QTL 21 2 3.1 0.0035 11.0 41358 D2Rat217 36213 D2Rat40 66654 D2Mco14 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 2 121545310 163154358 1 - by flanking markers 2 121490272 163104321 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582258 rat Bw76 Body weight QTL 76 17 4.6 5.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub
1582259 rat Gluco23 Glucose level QTL 23 14 3.1 8.0E-4 14.0 39030 D14Rat38 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 14 76579917 112194335 3 - by peak only 14 76599062 112220682 3 - by peak only 728161;737899 PD/Cub;BN/Cub intercross
1582260 rat Bw72 Body weight QTL 72 7 3.2 0.0043 15.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Metabolic Syndrome X;Obesity 1580752 15728334 7 1 41004865 4 - by one flank marker only 7 17382100 41025136 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582261 rat Bw69 Body weight QTL 69 7 3.2 0.0048 14.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 7 1 41004865 4 - by one flank marker only 7 17382100 41025136 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582262 rat Bw75 Body weight QTL 75 7 3.0 0.0038 14.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 7 1 41004865 4 - by one flank marker only 7 17382100 41025136 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1578763 rat Kidm29 Kidney mass QTL 29 1 3.3 1.0E-4 35174 D1Rat66 66610 D1Mco35 Kidney mass animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. abnormal kidney morphology Proteinuria;Albuminuria 1578520 16534143 1 183946692 267910886 2 - by one flank and peak markers 1 184096728 268121971 2 - by one flank and peak markers 10041;724574 SS/Jr;SHR/NHsd
1578764 rat Stresp19 Stress response QTL 19 19 3.6 0.001 41174 D19Rat71 Stress response plasma renin activity At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 recessive 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578765 rat Klgr1 Kidney lesion grade QTL 1 8 3.3 1.0E-4 41310 D8Rat130 33559 D8Mit5 34763 D8Rat62 Renal histology kidney lesion grade animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. Histological examination of the kidneys was done to assess the severity and extent of lesions. Proteinuria;Albuminuria 1578520 16534143 8 32203499 98986085 1 - by flanking markers 8 32212265 99005540 1 - by flanking markers 10041;724574 SS/Jr;SHR/NHsd
1578766 rat Tcas11 Tongue tumor susceptibility QTL 11 5 4.12 22.7 34467 D5Mgh16 11072 D5Mgh2 2324 Cdkn2b Tongue tumor susceptibility tongue tumor number animals given drinking water containing 0.001% 4NQO at six weeks of age until 180 days when they were sacrificed or until moribund. Measurements were taken of the diameter of tongue carcinomas in millimeters and the numbers of all tongue carcinomas abnormal Deiters cell morphology Tongue Neoplasms 1578522 16527513 5 17517235 168005953 1 - by flanking markers 5 17517235 168016142 1 - by flanking markers 60997;734761 DA;WF/Kga
1578767 rat Stresp17 Stress response QTL 17 5 4.3 0.01 41174 D19Rat71 Stress response plasma aldosterone At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 dominant 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578768 rat Stresp22 Stress response QTL 22 16 2.8 40320 D16Rat66 Stress response thymus weight At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 additive 16 39026337 84026337 3 - by peak only 16 39026413 84026413 3 - by peak only 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578769 rat Uae31 Urinary albumin excretion QTL 31 8 3.3 0.001 41310 D8Rat130 33559 D8Mit5 34763 D8Rat62 Renal function urine albumin level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. decreased albumin excretion Albuminuria;Proteinuria 1578520;2314528 16534143;19176703 8 32203499 98986085 1 - by flanking markers 8 32212265 99005540 1 - by flanking markers 10041;724574 SS/Jr;SHR/NHsd
1578770 rat Stresp23 Stress response QTL 23 1 60784 D1Wox29 11359 D1Arb21 Stress response sympathetic hyperreactivity to air-jet stress Animals were implanted with arterial and venous catheters and a renal nerve electrode. A seperate group of animals was implanted with a guide cannula for intracerebroventricular injection of 1 ug of candesartan, an ANG II type 1 receptor blocker. For each group, after baseline measurements of MAP, HR and renal sympathetic nerve activity (RSNA), a continuous air-jet stress was delivered to the face of a rat for 20 seconds two times. increased renal sympathetic nerve activity;increased systemic arterial blood pressure;increased heart rate 1 124614679 187092492 1 - by flanking markers 1 124693023 187242373 1 - by flanking markers 1302636 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm
1582197 rat Gluco27 Glucose level QTL 27 14 3.4 6.0E-4 15.0 41986 D14Arb10 39030 D14Rat38 39030 D14Rat38 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 14 76579917 112194335 3 - by peak only 14 76599062 112220682 3 - by peak only 728161;737899 PD/Cub;BN/Cub intercross
1582199 rat Insul5 Insulin level QTL 5 17 3.4 0.0119 12.0 40956 D17Rat107 38706 D17Rat84 40956 D17Rat107 Insulin level genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating insulin level Hyperinsulinism;Metabolic Syndrome X 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582201 rat Sffal2 Serum free fatty acids level QTL 2 14 4.0 2.0E-4 20.0 39030 D14Rat38 35897 D14Rat22 35897 D14Rat22 Lipid level free fatty acids genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome 1580752 15728334 14 99079814 102509397 1 - by flanking markers 14 99098960 102528608 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582203 rat Gluco19 Glucose level QTL 19 9 3.3 0.001 15.0 38036 D9Rat64 36027 D9Rat3 38036 D9Rat64 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 9 91131330 99799902 1 - by flanking markers 9 91336305 100009382 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582204 rat Livw1 Liver weight QTL 1 1 3.6 3.0E-4 13.0 35591 D1Rat47 34399 D1Mgh9 41532 D1Rat280 Liver weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased liver weight Metabolic Syndrome X 1580752 15728334 1 158511072 176855135 1 - by flanking markers 1 158590090 176994381 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582206 rat Kidm33 Kidney mass QTL 33 1 6.9 23.0 35851 D1Rat68 37902 D1Rat169 10768 D1Wox22 Kidney mass genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased kidney weight Metabolic Syndrome X 1580752 15728334 1 193069836 229876997 1 - by flanking markers 1 193219920 230041020 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582208 rat Kidm32 Kidney mass QTL 32 17 3.9 0.0018 14.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 Kidney mass genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased kidney weight Metabolic Syndrome X 1580752 15728334 17 15245341 29604237 1 - by flanking markers 17 15245341 29607065 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1582209 rat Gluco20 Glucose level QTL 20 14 3.8 5.0E-4 17.0 41986 D14Arb10 39030 D14Rat38 39030 D14Rat38 Glucose level uptake genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased circulating glucose level Metabolic Syndrome X;Hyperglycemia 1580752 15728334 14 76579917 112194335 3 - by peak only 14 76599062 112220682 3 - by peak only 728161;737899 PD/Cub;BN/Cub intercross
1582210 rat Bw71 Body weight QTL 71 3 3.3 0.0012 11.0 35589 D3Rat37 42664 D3Rat257 41296 D3Rat166 Body weight genome wide linkage analysis of 10 month old F2 male rats was carried out to identify QTL and interacting loci affecting a wide range of phenotypic traits, pharmacological and dietary conditions related to metabolic syndrome increased body weight Obesity;Metabolic Syndrome X 1580752 15728334 3 62558027 116023640 1 - by flanking markers 3 62454399 115929213 1 - by flanking markers 728161;737899 PD/Cub;BN/Cub intercross
1578758 rat Tcas9 Tongue tumor susceptibility QTL 9 6 3.29 35647 D6Rat55 Tongue tumor susceptibility tongue tumor number animals given drinking water containing 0.001% 4NQO at six weeks of age until 180 days when they were sacrificed or until moribund. Measurements were taken of the diameter of tongue carcinomas in millimeters and the numbers of all tongue carcinomas abnormal Deiters cell morphology Tongue Neoplasms 634723 11429048 6 1 25291384 3 - by peak only 6 0 25291250 3 - by peak only 60997;61007 DA;WF
1578759 rat Uae30 Urinary albumin excretion QTL 30 1 3.3 0.003 35174 D1Rat66 36703 D1Rat86 Renal function urine albumin level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. decreased albumin excretion Proteinuria;Albuminuria 1578520 16534143 1 183946692 267910886 2 - by one flank and peak markers 1 184096728 268121971 2 - by one flank and peak markers 10041;724574 SS/Jr;SHR/NHsd
1578760 rat Cm53 Cardiac mass QTL 53 9 3.3 1.0E-4 66431 D9Mco6 61287 D9Uia6 61287 D9Uia6 Cardiac mass animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. decreased heart weight Proteinuria;Albuminuria 1578520 16534143 9 77171049 105579863 1 - by flanking markers 9 77354334 105789343 1 - by flanking markers 10041;724574 SS/Jr;SHR/NHsd
1578761 rat Stresp21 Stress response QTL 21 10 3.3 39102 D10Rat71 Stress response thymus weight At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 recessive 10 7041744 52041744 3 - by peak only 10 7042794 52042794 3 - by peak only 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578762 rat Toxo1 Toxoplasma gondii resistance QTL 1 10 37986 D10Rat116 37720 D10Rat80 Toxoplasma gondii resistance animals were infected orally with 20 T. gondii Prugniaud strain cysts. One month later, blood was collected from the retroorbital sinus for anti-toxoplasma Ab response and 6 weeks after infection animals were killed to collect brains from quantification of T. gondii cysts decreased susceptibility to parasitic infection Toxoplasmosis 1578521 16407112 10 54220109 61798393 1 - by flanking markers 10 54233732 61812016 1 - by flanking markers 631593;631594;1578697 LEW/Rj;BN/Rj;BN.LEW-(D10Mco17-D10Rat31)/Ciml
1578771 rat Stresp20 Stress response QTL 20 8 3.7 0.05 10302 D8Mgh14 Stress response plasma renin activity At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. 1549862 16151695 recessive 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578772 rat Stresp14 Stress response QTL 14 2 5.0 0.001 40478 D2Rat277 38256 D2Rat115 39090 D2Rat180 Stress response plasma renin activity At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 2071 Agtr1b dominant 2 83433833 158985677 2 - by one flank and peak markers 2 83378795 158930639 2 - by one flank and peak markers 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578773 rat Iddm23 Insulin dependent diabetes mellitus QTL 23 20 2.9 Glucose level insulin-dependent rats were monitored by testing blood glucose levels twice weekly until 120 days old , diabetic rats sacrificed within 48 hours of hyperglycemia onset; the pancreas was dissected and examined for autoimmune infiltration of islets hyperglycemia;abnormal pancreatic islet morphology;increased susceptibility to autoimmune disorder Hyperglycemia;Diabetes Mellitus, Insulin-Dependent 1547853 16075370 1311139 Aire 1578710;1578713 LEW.1AR1-iddm/Ztm;BN/Ztm
1578774 rat Tcas8 Tongue tumor susceptibility QTL 8 5 3.47 34377 D5Mgh4 Tongue tumor susceptibility tongue tumor number animals given drinking water containing 0.001% 4NQO at six weeks of age until 180 days when they were sacrificed or until moribund. Measurements were taken of the diameter of tongue carcinomas in millimeters and the numbers of all tongue carcinomas abnormal Deiters cell morphology Tongue Neoplasms 634723 11429048 60997;61007 DA;WF
1578775 rat Iddm21 Insulin dependent diabetes mellitus QTL 21 1 4.13 42536 D1Rat496 Glucose level insulin-dependent rats were monitored by testing blood glucose levels twice weekly until 120 days old , diabetic rats sacrificed within 48 hours of hyperglycemia onset; the pancreas was dissected and examined for autoimmune infiltration of islets hyperglycemia;abnormal pancreatic islet morphology;increased susceptibility to autoimmune disorder Hyperglycemia;Diabetes Mellitus, Insulin-Dependent 1547853 16075370 2915;1308521 Ins1;Nkx2-3 1578710;1578713 LEW.1AR1-iddm/Ztm;BN/Ztm
1578776 rat Stresp18 Stress response QTL 18 5 2.9 35076 D5Rat6 Stress response thymus weight At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 recessive 5 30030683 75030683 3 - by peak only 5 30030959 75030959 3 - by peak only 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578777 rat Stresp15 Stress response QTL 15 2 2.0 0.05 40478 D2Rat277 Stress response plasma aldosterone At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 2071 Agtr1b dominant 2 60933945 105933945 3 - by peak only 2 60878907 105878907 3 - by peak only 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578778 rat Pur4 Proteinuria QTL 4 1 3.3 0.003 36703 D1Rat86 36703 D1Rat86 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. decreased protein excretion Proteinuria;Albuminuria 1578520 16534143 1 236673382 267910886 3 - by peak only 1 236939323 268121971 3 - by peak only 10041;724574 SS/Jr;SHR/NHsd
1578779 rat Tcas10 Tongue tumor susceptibility QTL 10 10 3.12 11479 D10Mit8 Tongue tumor susceptibility tongue tumor number animals given drinking water containing 0.001% 4NQO at six weeks of age until 180 days when they were sacrificed or until moribund. Measurements were taken of the diameter of tongue carcinomas in millimeters and the numbers of all tongue carcinomas abnormal Deiters cell morphology Tongue Neoplasms 634723 11429048 10 33351756 78351756 3 - by peak only 10 33365379 78365379 3 - by peak only 60997;61007 DA;WF
1578780 rat Cm52 Cardiac mass QTL 52 1 3.3 1.0E-4 66589 D1Mco25 37168 D1Rat158 Cardiac mass animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. decreased heart weight Proteinuria;Albuminuria 1578520 16534143 1 131078494 176078494 3 - by peak only 1 81420920 225892882 2 - by one flank and peak markers 10041;724574 SS/Jr;SHR/NHsd
1578754 rat Stresp16 Stress response QTL 16 3 4.0 0.001 33927 D3Mit3 Stress response plasma renin activity At 15 weeks of age, animals were subjected to 20 min. of restraint stress. Endocrine levels of ACTH, coticosterone, aldosterone and plasma renin activity were measured before and after restraint. Adrenal and thymus glands were removed and weighed. 1549862 16151695 recessive 3 113902006 158902006 3 - by peak only 3 113807580 158807580 3 - by peak only 1354669;1554301 BN/OrlIcoCrlf;WKHA/Bord
1578755 rat Pur5 Proteinuria QTL 5 8 3.3 1.0E-4 33559 D8Mit5 41310 D8Rat130 34763 D8Rat62 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. decreased protein excretion Proteinuria;Albuminuria 1578520;2314528 16534143;19176703 8 32203394 98986263 1 - by flanking markers 8 32212161 99005718 1 - by flanking markers 10041;724574 SS/Jr;SHR/NHsd
1578756 rat Iddm22 Insulin dependent diabetes mellitus QTL 22 1 2.7 38202 D1Rat229 33931 D1Mit10 Glucose level insulin-dependent rats were monitored by testing blood glucose levels twice weekly until 120 days old , diabetic rats sacrificed within 48 hours of hyperglycemia onset; the pancreas was dissected and examined for autoimmune infiltration of islets hyperglycemia;abnormal pancreatic islet morphology;increased susceptibility to autoimmune disorder Hyperglycemia;Diabetes Mellitus, Insulin-Dependent 1547853 16075370 3732 Sod2 1578710;1578713 LEW.1AR1-iddm/Ztm;BN/Ztm
1578757 rat Pur6 Proteinuria QTL 6 9 3.3 0.005 62516 D9Uia4 66431 D9Mco6 61287 D9Uia6 Renal function urine protein level animals were kept in a metabolism cage on a low-salt diet (0.3%NaCl) until 8 weeks of age when they were placed on a high-salt diet (2% NaCl) for the duration of the experiment. Animals were measured for blood pressure, and urine was collected to measure urinary protein excretion and urinary albumin excretion. decreased protein excretion Proteinuria;Albuminuria 1578520 16534143 9 59247346 105580061 1 - by flanking markers 9 59394328 105789541 1 - by flanking markers 10041;724574 SS/Jr;SHR/NHsd
1558640 rat Prcs2 Prostate cancer susceptibility QTL 2 20 3.3 37594 D20Rat41 35657 D20Rat5 34872 D20Rat3 Prostate tumor susceptibility lesions with ACI-type nuclei animals were sacrificed at 30 months of age and male sex orgains and bladder were resected. The vetral prostate was fixed, removed from bse of bladder neck and weighed. Hyperplastic and tumorous lesions were classified by structure and atypical nuclei. prostate gland hyperplasia;abnormal sciatic nerve;abnormal prostate gland physiology;abnormal prostate gland morphology Prostatic Neoplasms 1358944 15805257 69328 Cdkn1a dominant 20 4740609 18411969 1 - by flanking markers 20 4740837 18426179 1 - by flanking markers 737892;1547866 ACI/SegHsd;F344/Jcl
1558641 rat Cm47 Cardiac mass QTL 47 6 2.9 0.001 34126 D6Mgh4 33977 D6Mit4 34306 D6Mgh5 Cardiac mass body weight adjusted Systolic blood pressure was measured by the tail cuff method and total body weight and heart weight of each rat was measured and recorded. cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 6 59946628 92813798 2 - by one flank and peak markers 6 59950000 108507129 1 - by flanking markers 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558642 rat Prcr2 Prostate cancer resistance QTL 2 1 4.3 38028 D1Rat121 38134 D15Rat45 37974 D1Rat211 Prostate tumor resistance lesions with ACI-type nuclei area ratio animals were sacrificed at 30 months of age and male sex organs and bladder were resected. The ventral prostate was fixed, removed from base of bladder neck and weighed. Hyperplastic and tumorous lesions were classified by structure and atypical nuclei. prostate gland hypoplasia;abnormal sciatic nerve;abnormal prostate gland physiology;abnormal prostate gland morphology Prostatic Neoplasms 1358944 15805257 737892;1547866 ACI/SegHsd;F344/Jcl
1558643 rat Cm44 Cardiac mass QTL 44 10 4.8 3.68E-5 34445 D10Mgh6 34128 D10Mgh1 3177 Ngfr Cardiac mass body weight adjusted Systolic blood pressure was measured by the tail cuff method and total body weight and heart weight of each rat was measured and recorded. cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 10 61771905 106771905 3 - by peak only 10 61786274 106786274 3 - by peak only 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558644 rat Cm45 Cardiac mass QTL 45 13 3.6 0.002 11374 D13Wox6 Cardiac mass body weight adjusted Systolic blood pressure was measured by the tail cuff method and total body weight and heart weight of each rat was measured and recorded. cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 13 25198204 70198204 3 - by peak only 13 25212247 70212247 3 - by peak only 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558645 rat Bw55 Body weight QTL 55 1 3.2 0.004 621323 Phox2a Body weight increased body weight;abnormal body weight 1554311 16097372 1 136792830 181792830 3 - by peak only 1 136854644 181854644 3 - by peak only 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558646 rat Swd5 Spike wave discharge measurement QTL 5 8 3.45 3.6E-4 12.0 44394 D8Got49 Spike wave discharge measurement frequency rats were permanently implanted with standard EEG electrodes At twelve weeks, animals were familiarized with EEG recordings. Animals were classified acording to the EEG hallmark and severity of SWDs. Total number, amplitude, frequency and total duration of SWDs were measured at 3 months and 6 months of age. absence seizures Epilepsy, Absence 1553898 15030491 8 16442231 61442231 3 - by peak only 8 16450997 61450997 3 - by peak only 1354669;1554304 BN/OrlIcoCrlf;GAERS/Mave
1558647 rat Cm46 Cardiac mass QTL 46 3 5.4 5.5E-6 33862 D3Mit9 34347 D3Mgh16 34198 D3Mgh8 Cardiac mass body weight adjusted Systolic blood pressure was measured by the tail cuff method and total body weight and heart weight of each rat was measured and recorded. cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 3 6373454 26674018 1 - by flanking markers 3 6373754 26570390 1 - by flanking markers 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558648 rat Smcn1 Smooth muscle cell number QTL 1 2 0.039 3407 Prlr 40466 D2Rat303 Smooth muscle cell number aorta male rats were fed a high salt diet from 35 days of age and telemetry probes were implanted at day 56 of age. Rat were sacrificed at 14 weeks of age and organs of interest were collected. Aortic cross sectional area was measured and smooth muscle cell number was determined from aortic rings sectioned perpendicular to the longituinal axis of the vessel. vascular smooth muscle cell hyperplasia Aortic Diseases 1357419 15741507 2071 Agtr1b 2 59507966 131522430 1 - by flanking markers 2 59485049 131472404 1 - by flanking markers 1357978 SS.MNS-(D2Mit6-D2Rat303)/Ayd
1558649 rat Bw58 Body weight QTL 58 18 3.4 5.0E-4 34290 D18Mgh4 Body weight increased body weight;abnormal body weight 1554311 16097372 18 57158343 87338544 3 - by peak only 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558650 rat Cm48 Cardiac mass QTL 48 3 4.0 1.0E-4 33862 D3Mit9 34347 D3Mgh16 34347 D3Mgh16 Cardiac mass body weight adjusted Systolic blood pressure was measured by the tail cuff method and total body weight and heart weight of each rat was measured and recorded. cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 3 6373454 26674018 1 - by flanking markers 3 6373754 26570390 1 - by flanking markers 1558661;1558662 WKY/Tkyo;SHR/Tkyo
1558651 rat Swd3 Spike wave discharge measurement QTL 3 4 4.62 2.4E-5 13.7 43803 D4Got39 60456 D4Got74 10144 D4Mgh16 Spike wave discharge measurement frequency rats were permanently implanted with standard EEG electrodes At twelve weeks, animals were familiarized with EEG recordings. Animals were classified acording to the EEG hallmark and severity of SWDs. Total number, amplitude, frequency and total duration of SWDs were measured at 3 months and 6 months of age. absence seizures Epilepsy, Absence 1553898 15030491 4 56704868 91916048 1 - by flanking markers 4 56980168 92160473 1 - by flanking markers 1354669;1554304 BN/OrlIcoCrlf;GAERS/Mave
1558652 rat Bw57 Body weight QTL 57 10 4.2 8.0E-4 2493 Ace 34128 D10Mgh1 743897 CF112743 Body weight increased body weight;abnormal body weight 1554311 16097372 10 95361338 110718848 4 - by one flank marker only 10 95375707 110733352 4 - by one flank marker only 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558653 rat Prcr1 Prostate cancer resistance QTL 1 2 5.0 20.3 36093 D2Rat26 36213 D2Rat40 38362 D2Rat161 Prostate tumor resistance lesion area ratio animals were sacrificed at 30 months of age and male sex organs and bladder were resected. The ventral prostate was fixed, removed from base of bladder neck and weighed. Hyperplastic and tumorous lesions were classified by structure and atypical nuclei. prostate gland hypoplasia;abnormal sciatic nerve;abnormal prostate gland physiology;abnormal prostate gland morphology Prostatic Neoplasms 1358944 15805257 3098 Mme dominant 2 73374972 163154358 2 - by one flank and peak markers 2 73314755 163104321 2 - by one flank and peak markers 737892;1547866 ACI/SegHsd;F344/Jcl
1558654 rat Bw56 Body weight QTL 56 3 4.5 1.71E-5 34347 D3Mgh16 33862 D3Mit9 34347 D3Mgh16 Body weight increased body weight;abnormal body weight 1554311 16097372 3 6373335 26674263 1 - by flanking markers 3 6373636 26570635 1 - by flanking markers 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558655 rat Swd4 Spike wave discharge measurement QTL 4 7 3.68 2.0E-4 12.0 34511 D7Mgh5 Spike wave discharge measurement grading rats were permanently implanted with standard EEG electrodes At twelve weeks, animals were familiarized with EEG recordings. Animals were classified acording to the EEG hallmark and severity of SWDs. Total number, amplitude, frequency and total duration of SWDs were measured at 3 months and 6 months of age. absence seizures Epilepsy, Absence 1553898 15030491 7 93320292 138320292 3 - by peak only 7 93354522 138354522 3 - by peak only 1354669;1554304 BN/OrlIcoCrlf;GAERS/Mave
1558656 rat Prcs1 Prostate cancer susceptibility QTL 1 19 5.0 17.6 38032 D19Rat101 39212 D19Rat46 40998 D19Rat75 Prostate tumor susceptibility lesions with ACI-type nuclei animals were sacrificed at 30 months of age and male sex organs and bladder were resected. The ventral prostate was fixed, removed from base of bladder neck and weighed. Hyperplastic and tumorous lesions were classified by structure and atypical nuclei. prostate gland hyperplasia;abnormal sciatic nerve;abnormal prostate gland physiology;abnormal prostate gland morphology Prostatic Neoplasms 1358944 15805257 19 16245310 36472155 1 - by flanking markers 19 16250136 36477036 1 - by flanking markers 737892;1547866 ACI/SegHsd;F344/Jcl
1558657 rat Cm43 Cardiac mass QTL 43 3 6.6 2.93E-8 33862 D3Mit9 34347 D3Mgh16 34198 D3Mgh8 Cardiac mass body weight adjusted Systolic blood pressure was measured by the tail cuff method and total body weight and heart weight of each rat was measured and recorded. cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 3 6373454 26674018 1 - by flanking markers 3 6373754 26570390 1 - by flanking markers 1558660;1558661 SHRSP/Tkyo;WKY/Tkyo
1558658 rat Bw59 Body weight QTL 59 1 3.5 3.0E-4 36580 D1Rat112 Body weight increased body weight;abnormal body weight 1554311 16097372 1 184074275 229074275 3 - by peak only 1 184227729 229227729 3 - by peak only 1558661;1558662 WKY/Tkyo;SHR/Tkyo
1558659 rat Tescar1 Testicular tumor resistance QTL 1 11 3.9 39504 D11Rat88 39084 D11Rat93 Testicular tumor resistance animals were sacrificed at 30 months of age and male sex organs and bladder were resected. The ventral prostate was fixed, removed from base of bladder neck and weighed. Hyperplastic and tumorous lesions were classified by structure and atypical nuclei. testis tumor;small Rosenthal canal Testicular Neoplasms 1358944 15805257 11 597138 67931151 1 - by flanking markers 11 597128 67988740 1 - by flanking markers 737892;1547866 ACI/SegHsd;F344/Jcl
1549897 rat Stresp12 Stress response QTL 12 13 3.35 3.4 38396 D13Rat77 Stress response defensive burying - approach animals behavioral response to a stressful stimulus was measured with the defensive burying test, which consists of delivery of an electric shock prod to the animal; coping responses include a latency to and duration of defensive burying of the prod in bedding, or approach to the prod and number of shocks received decreased coping response;increased anxiety-related response;abnormal coping response Anxiety Disorders 1358767 15685431 additive 13 40675437 85675437 3 - by peak only 13 40689500 85689500 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1549898 rat Neuinf3 Neuroinflammation QTL 3 10 26.0 59985 D10Got6 33591 D10Mit14 34361 D10Mgh25 Neuroinflammation MHC class II expression CD+ T lymphocytes were counted in the ventral horn in the L4 spinal cord segment. abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 1358146;1358788 15821736;14586010 619813 Ciita additive 10 3219701 5339859 1 - by flanking markers 10 3219701 5339859 1 - by flanking markers 737658;737950 PVG.1AV1;DA/Ztm
1549899 rat Stresp8 Stress response QTL 8 7 4.37 8.0E-4 0.5 37360 D7Rat68 Stress response defensive burying - shocks animals behavioral response to a stressful stimulus was measured with the defensive burying test, which consists of delivery of an electric shock prod to the animal; coping responses include a latency to and duration of defensive burying of the prod in bedding, or approach to the prod and number of shocks received decreased coping response;increased anxiety-related response;abnormal coping response Anxiety Disorders 1358767 15685431 7 97285400 142285400 3 - by peak only 7 97319630 142319630 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1549900 rat Iddm20 Insulin dependent diabetes mellitus QTL 20 17 3.7 38992 D17Rat61 40000 D17Rat115 Glucose level plasma glucose following exposure to Kilham rat virus and poly I:C, animals were screened three times weekly for glycosuria and diabetes was diagnosed on the basis of a plasma glucose concentration >11.1 mmol/l autoimmune response;hyperglycemia Diabetes Mellitus, Insulin-Dependent 1358924;2313174 15793267;19720792 3796 Syk incomplete_dominance 17 19877005 27819082 1 - by flanking markers 17 19877081 27822133 1 - by flanking markers 1304487;1359010 BBDR/Wor;WF.BBDR-ART2a/Wor
1549901 rat Neudeg2 Neurodegradation QTL 2 5 4.0 0.0 39160 D5Rat73 38548 D5Rat82 39186 D5Rat70 Neurodegradation Motoneuron cell number Motor neurons were counted in the lateral motor nuclei in the L4 spinal chord segment. decreased motor neuron number;increased double-negative T cell number Central Nervous System Diseases;Neurodegenerative Diseases 1358788;1358768;2317162 14586010;15894332;19526058 additive 5 25602274 45822846 1 - by flanking markers 5 25452401 45823025 1 - by flanking markers 629486;737950 PVG/OlaHsd;DA/Ztm
1549902 rat Bp269 Blood pressure QTL 269 12 41962 D12Arb6 Blood pressure diastolic, daytime At 5 weeks of age, rats were started on an 8% NaCl diet. Radiotelemetry devices were implanted into the lower abdominal aorta and at 14 weeks of age, blood pressure and heart rate were continously measured for 44 hours. increased systemic arterial diastolic blood pressure Hypertension 1358144 15809361 12 14394598 46782294 3 - by peak only 12 14257986 46649226 3 - by peak only 69369;631576 SS;LEW/CrlCrlj
1549903 rat Bp267 Blood pressure QTL 267 1 10333 D1Arb33 34381 D1Mgh7 36765 D1Rat27 Blood pressure systolic, nighttime At 5 weeks of age, rats were started on an 8% NaCl diet. Radiotelemetry devices were implanted into the lower abdominal aorta and at 14 weeks of age, blood pressure and heart rate were continously measured for 44 hours. increased systemic arterial systolic blood pressure;increased systemic arterial diastolic blood pressure Hypertension 1358144 15809361 3175;1306420 Klk1b3;Klk7 1 77541583 106445306 1 - by flanking markers 1 77619694 106523649 1 - by flanking markers 69369;631576 SS;LEW/CrlCrlj
1549904 rat Neuinf1 Neuroinflammation QTL 1 5 3.0 0.0 41492 D5Rat178 41798 D5Rat246 35823 D5Rat50 Neuroinflammation T lymphocyte CD3+ number CD+ T lymphocytes were counted in the ventral horn in the L4 spinal cord segment. increased double-negative T cell number Central Nervous System Diseases 1358788;1358768 14586010;15894332 additive 5 161449395 173096209 4 - by one flank marker only 5 161459512 173106704 4 - by one flank marker only 629486;737950 PVG/OlaHsd;DA/Ztm
1549905 rat Stresp10 Stress response QTL 10 6 6.83 0.0066 2.7 35963 D6Rat46 Stress response defensive burying - approach animals behavioral response to a stressful stimulus was measured with the defensive burying test, which consists of delivery of an electric shock prod to the animal; coping responses displayed include a latency to and duration of defensive burying of the prod in bedding, or approach to the prod and number of shocks received decreased coping response;increased anxiety-related response;abnormal coping response Anxiety Disorders 1358767 15685431 6 1 35786687 3 - by peak only 6 0 35786687 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1549907 rat Neuinf2 Neuroinflammation QTL 2 10 27.0 0.0 37464 D10Rat95 38062 D10Rat96 Neuroinflammation MHC class II expression CD+ T lymphocytes were counted in the ventral horn in the L4 spinal cord segment. abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 1358146;1358788;1358768 15821736;14586010;15894332 additive 10 6172805 6380753 1 - by flanking markers 10 6172805 6380796 1 - by flanking markers 629486;737950 PVG/OlaHsd;DA/Ztm
1549908 rat Neudeg1 Neurodegradation QTL 1 8 5.0 0.0 37742 D8Rat163 40736 D8Rat129 41794 D8Rat205 Neurodegradation Motoneuron cell number Motor neurons were counted in the lateral motor nuclei in the L4 spinal chord segment. motor neuron degeneration;decreased motor neuron number Neurodegenerative Diseases 1358768;1358788;2317162 15894332;14586010;19526058 additive 8 31508524 98947320 1 - by flanking markers 8 31517291 98966882 1 - by flanking markers 629486;737950;2317196;2317197;2317201 PVG/OlaHsd;DA/Ztm;DA.PVG.1AV1-(D8Rat146-D8Got145);DA.PVG.1AV1-(D8Rat41-D8Rat24);DA.PVG.1AV1-(D8Rat24-D8Got145)
1549909 rat Stresp11 Stress response QTL 11 8 6.83 0.0019 2.1 37818 D8Rat66 Stress response defensive burying - coping animals behavioral response to a stressful stimulus was measured with the defensive burying test; the coping trait concerns the number of shocks an animal recieves, latency to and duration of the defensive burying response to an electric shock and an animals approach to the prod decreased coping response;increased anxiety-related response;abnormal coping response Anxiety Disorders 1358767 15685431 8 78008525 123008525 3 - by peak only 8 78027980 123027980 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1549910 rat Bw54 Body weight QTL 54 1 0.05 37356 D1Rat225 35457 D1Rat90 Body weight increased body weight;abnormal fat pad morphology Obesity 1358859 15883013 3360 Pnlip additive 1 261180160 267111153 1 - by flanking markers 1 261391205 267322172 1 - by flanking markers 1358995 F344.OLETF-(D1Rat166-D1Rat90)/Tj
1549911 rat Stresp9 Stress response QTL 9 1 6.13 0.0035 1.7 39116 D1Rat145 Stress response defensive burying - approach animals behavioral response to a stressful stimulus was measured with the defensive burying test, which consists of delivery of an electric shock prod to the animal; coping responses displayed include a latency to and duration of defensive burying of the prod in bedding, or approach to the prod and number of shocks received decreased coping response;increased anxiety-related response;abnormal coping response Anxiety Disorders 1358767 15685431 1 225366432 267910886 3 - by peak only 1 225480980 268121971 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1549912 rat Bp268 Blood pressure QTL 268 10 41962 D12Arb6 Blood pressure diastolic, daytime At 5 weeks of age, rats were started on an 8% NaCl diet. Radiotelemetry devices were implanted into the lower abdominal aorta and at 14 weeks of age, blood pressure and heart rate were continously measured for 44 hours. increased systemic arterial systolic blood pressure;increased systemic arterial diastolic blood pressure Hypertension 1358144;1625680 15809361;17460389 12 14394598 46782294 3 - by peak only 12 14257986 46649226 3 - by peak only 69369;631576 SS;LEW/CrlCrlj
1549913 rat Stresp13 Stress response QTL 13 2 4.56 0.0011 1.8 39914 D2Rat188 Stress response defensive burying - latency animals behavioral response to a stressful stimulus was measured with the defensive burying test, which consists of delivery of an electric shock prod to the animal; coping responses include a latency to and duration of defensive burying of the prod in bedding, or approach to the prod and number of shocks received decreased coping response;increased anxiety-related response;abnormal coping response Anxiety Disorders 1358767 15685431 61105;61109 WKY/NHsd;F344/NHsd
1559282 rat Emca5 Estrogen-induced mammary cancer QTL 5 3 3.9 41780 D3Rat227 40440 D3Rat210 37980 D3Rat114 Mammary tumor susceptibility estradiol-induced time to appearance of palpable mammary tumor following initiation of estradiol treatment mammary adenocarcinoma Breast Neoplasms 1642522;2291885 16885383;18057545 dominant 3 41054012 171063335 2 - by one flank and peak markers 3 40950385 170969371 2 - by one flank and peak markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1559283 rat Emca4 Estrogen-induced mammary cancer QTL 4 7 3.7 34999 D7Rat44 36661 D7Rat15 35841 D7Rat19 Mammary tumor susceptibility estradiol-induced time to appearance of palpable mammary tumor following initiation of estradiol treatment mammary adenocarcinoma Breast Neoplasms 1642522;2291885 16885383;18057545 dominant 7 66201980 107428439 1 - by flanking markers 7 66222710 107462669 1 - by flanking markers 10008;737892 BN/SsNHsd;ACI/SegHsd
1549848 rat Bvd6 Brain ventricular dilatation QTL 6 11 3.1 1.0E-4 4.5 39084 D11Rat93 41692 D11Rat89 37942 D11Rat46 Head/brain development brain ventricular dilatation brain ventricular dilatation, representing inherited hydrocephalus, in 2-22 day old animals was assessed in fixed brain slices; coronal brain slices at 1.0 mm thickness were assessed for width of striatum ventricles versus width of brain to score hydrocephalus severity hydroencephaly Hydrocephalus 68196;68693 11178739;11178739 3761 Sst 11 67930910 87759784 2 - by one flank and peak markers 11 67988499 87800381 2 - by one flank and peak markers 60994;68189 F344;HTX/Hcj
1559055 rat Bp278 Blood pressure QTL 278 17 0.04 37234 D17Rat97 43089 D17Rat181 Blood pressure mean arterial mean arterial, systolic, and diastolic blood pressures were measured in congenic strains and substrains constructed to span a region of chromosome 17 containing blood pressure QTL increased systemic arterial blood pressure Hypertension 1547847;1601352 15632271;17420333 17 38257371 73041111 1 - by flanking markers 17 38260212 73051944 1 - by flanking markers 1559033;1559035 SS.LEW-(D17Rat65-Prl)/Ayd;SS.LEW-(D17Chm14-D17Rat181)/Ayd
1598875 rat Bp286 Blood pressure QTL 286 3 2.0 9.0E-4 1582000 D3Mco44 66731 D2Mco36 Blood pressure systolic substitution mapping was done by the generation of subcongenic strains to refine the region affecting systolic blood pressure decreased systemic arterial systolic blood pressure;increased kidney weight Hypotension 2306800;1581650 19255363;17028336 68438;629471;1306721 Oprl1;Rgs19;Rtel1 2 65484323 110484323 4 - by one flank marker only 2 65429285 110429285 4 - by one flank marker only 1582185;1582188 SS.SR-(D3Mco36-D3Got166)/Jr;SS.SR-(D3Mco36-D3Mco46)/Jr
1598877 rat Bp285 Blood pressure QTL 285 3 1.5 0.03 1582056 D3Mco81 1582102 D3Mco75 Blood pressure systolic substitution mapping was done by the generation of subcongenic strains to refine the region affecting systolic blood pressure decreased systemic arterial systolic blood pressure Hypotension 2306800;1581650 19255363;17028336 3781 Eef1a2 1582185;1582187 SS.SR-(D3Mco36-D3Got166)/Jr;SS.SR-(D3Mco24-D3Got130)/Jr
1600362 rat Mcs19 Mammary carcinoma susceptibility QTL 19 5 2.5 40574 D5Rat196 41560 D5Rat153 40574 D5Rat196 Mammary tumor susceptibility tumor number mammary adenocarcinoma Mammary Neoplasms;Adenocarcinoma 1599317 16596452 5 103956411 108590465 1 - by flanking markers 5 103961587 108595691 1 - by flanking markers 737895;737962 WKY/HanZtm;SPRD/HanZtm backcross
1600363 rat Hc6 Hypercalciuria QTL 6 1 2.7 35741 D1Rat32 33830 D1Mit32 37902 D1Rat169 Renal function calcium excretion whole genome microarray expression profiling of the kidney, small intestine and femoral osteoclast cells (OC) was done on 8 weeks old animals which were on 1.2% calcium diet for 9 days, then on 0.02% calcium diet; urine calcium excretion was measured hypercalciuria;nephrolithiasis Kidney Calculi 1582396 16611718 3562;620771;727801 Rgs10;Ptpre;Nadsyn1 1 112148733 250430505 1 - by flanking markers 1 112227076 250691074 1 - by flanking markers 1598804 WKY.GHS-(D1Rat32-D1Mit32)
1600365 rat Mcs20 Mammary carcinoma susceptibility QTL 20 9 3.0 35623 D9Rat41 39246 D9Rat63 41772 D9Rat158 Mammary tumor susceptibility time between onset and peak mammary adenocarcinoma Mammary Neoplasms;Adenocarcinoma 1599317 16596452 9 8991206 39691794 1 - by flanking markers 9 8988529 39693208 1 - by flanking markers 737895;737962 WKY/HanZtm;SPRD/HanZtm backcross
1600367 rat Mcs15 Mammary carcinoma susceptibility QTL 15 10 4.5 44808 D10Got124 34128 D10Mgh1 35627 D10Rat12 Mammary tumor susceptibility linkage study on 50-55 days old rats was done after 65 mg/kg body weight of DMBA was given to induce mammary carcinoma; all tumors larger than 3mm were counted mammary adenocarcinoma Mammary Neoplasms 1581951 16568087 2218 Brca1 10 89575059 108822775 2 - by one flank and peak markers 10 89589430 108837146 2 - by one flank and peak markers 1598797 WF.WKY-(D10Got124-D10Rat187)/Uwm
1600369 rat Hcas8 Hepatocarcinoma susceptibility QTL 8 16 33652 D16Mit5 40052 D16Rat75 Liver tumor susceptibility nodule number number of neoplastic nodules abnormal olfactory -discrimination memory;increased hepatocyte proliferation Carcinoma, Hepatocellular 1599590 17079458 16 1 24132402 4 - by one flank marker only 16 0 24132224 4 - by one flank marker only 1599755 F344.BN-(D16Mit5-D16Rat75)
1600371 rat Mcs21 Mammary carcinoma susceptibility QTL 21 10 3.0 39102 D10Rat71 37986 D10Rat116 39102 D10Rat71 Mammary tumor susceptibility tumor growth rate increased tumor incidence;mammary adenocarcinoma Mammary Neoplasms;Adenocarcinoma 2302423;1599317 19052818;16596452 10 29541648 54220239 1 - by flanking markers 10 29542698 54233862 1 - by flanking markers 737895;737962 WKY/HanZtm;SPRD/HanZtm backcross
1600373 rat Mamtr6 Mammary tumor resistance QTL 6 18 40096 D18Rat102 39278 D18Rat44 Mammary tumor resistance tumor number mammary adenocarcinoma;decreased incidence of chemically-induced tumors Adenocarcinoma 1643011;2302423;1599390 17597107;19052818;17230524 18 19892650 86863411 1 - by flanking markers 18 19919296 86936861 1 - by flanking markers 1599760 SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm
1600374 rat Mcs17 Mammary carcinoma susceptibility QTL 17 1 3.0 38954 D1Rat181 35372 D1Rat88 35372 D1Rat88 Mammary tumor susceptibility tumor number mammary adenocarcinoma Mammary Neoplasms;Adenocarcinoma 1599317 16596452 1 202763018 247763018 4 - by one flank marker only 1 202923480 247923480 4 - by one flank marker only 737895;737962 WKY/HanZtm;SPRD/HanZtm backcross
1600375 rat Mcs22 Mammary carcinoma susceptibility QTL 22 18 3.3 37568 D18Rat55 36638 D18Rat14 36638 D18Rat14 Mammary tumor susceptibility tumor growth rate increased tumor incidence;mammary adenocarcinoma Mammary Neoplasms;Adenocarcinoma 2302423;1599317 19052818;16596452 18 54856551 67024547 1 - by flanking markers 18 54928784 67097748 1 - by flanking markers 737895;737962 WKY/HanZtm;SPRD/HanZtm backcross
1600376 rat Arunc5 Aerobic running capacity QTL 5 3 0.21 40204 D3Rat233 34411 D3Mgh14 Aerobic running capacity treadmill exercise test increased aerobic running capacity 1598978 17179209 3 73863223 118863223 4 - by one flank marker only 3 73768796 118768796 4 - by one flank marker only 1599769 COP.DA-(D3Rat233-D3Mgh14)/Mco
1600378 rat Arunc4 Aerobic running capacity QTL 4 16 0.03 36892 D16Rat12 38444 D16Rat90 Aerobic running capacity treadmill exercise test increased aerobic running capacity 1598978 17179209 620427;1306769 Pdlim3;Tm2d2 16 350121 85734479 1 - by flanking markers 16 350122 85720519 1 - by flanking markers 1599764 COP.DA-(D16Rat12-D16Rat90)/Mco
1600379 rat Mcs18 Mammary carcinoma susceptibility QTL 18 2 2.6 33822 D2Mit29 37018 D2Rat14 36089 D2Rat4 Mammary tumor susceptibility tumor number mammary adenocarcinoma Mammary Neoplasms;Adenocarcinoma 1599317 16596452 2 5601528 35247992 2 - by one flank and peak markers 2 5627976 35062282 2 - by one flank and peak markers 737895;737962 WKY/HanZtm;SPRD/HanZtm backcross
1600380 rat Niddm70 Non-insulin dependent diabetes mellitus QTL 70 1 3.1 8.0E-4 11.0 34244 D1Mgh10 Insulin level insulin secretion test (IVGTT) 1598974 16783636 1 181780342 226780342 3 - by peak only 1 181933810 226933810 3 - by peak only 1600339 BN.GK-(D1Wox18-D1Got254)/Ox
1600382 rat Edcs3 Endometrial carcinoma susceptibility QTL3 20 3.5 0.003 11207 D20Wox5 37490 D20Rat21 11207 D20Wox5 Endometrial tumor susceptibility onset of tumor development endometrial carcinoma Endometrial Neoplasms;Carcinoma, Endometrioid 1599853;1599856 15796960;11745480 2252;3020;3817;3818;3876 Ddr1;Lta;Tap1;Tap2;Tnf 20 1 1675005 4 - by one flank marker only 20 0 1675005 4 - by one flank marker only 737945;737947 BN/Han;BDII/Ztm intercross
1600358 rat Mamtr5 Mammary tumor resistance QTL 5 5 40716 D5Rat124 39276 D5Rat114 Mammary tumor resistance tumor number mammary adenocarcinoma;increased tumor growth/size Adenocarcinoma 1643011;1599390 17597107;17230524 5 19206257 64206257 4 - by one flank marker only 5 19206258 64206258 4 - by one flank marker only 1599763 SPRD.WKY-(D5Rat190-D5Rat114)/Ibmm
1600360 rat Mcs16 Mammary carcinoma susceptibility QTL 16 1 2.4 39666 D1Rat246 36626 D1Rat15 39666 D1Rat246 Mammary tumor susceptibility tumor number mammary adenocarcinoma Mammary Neoplasms;Adenocarcinoma 1599317 16596452 1 2436832 37799020 1 - by flanking markers 1 2436833 37801965 1 - by flanking markers 737895;737962 WKY/HanZtm;SPRD/HanZtm backcross
1578646 rat Bmd18 Bone mineral density QTL 18 15 5.2 41564 D15Rat80 40516 D15Rat106 Bone mineral density femoral neck trabecular vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 15 25506124 106177917 1 - by flanking markers 15 25521824 106193697 1 - by flanking markers 60994;60999 F344;LEW
1578647 rat Bmd17 Bone mineral density QTL 17 15 4.0 41564 D15Rat80 40516 D15Rat106 Bone mineral density femoral neck total vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 15 25506124 106177917 1 - by flanking markers 15 25521824 106193697 1 - by flanking markers 60994;60999 F344;LEW
1578648 rat Bss11 Bone structure and strength QTL 11 2 4.7 38362 D2Rat161 39878 D2Rat242 Bone structure femoral neck cortical area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 2 118264490 220244597 1 - by flanking markers 2 118209465 220207659 1 - by flanking markers 60994;60999 F344;LEW
1578649 rat Bmd8 Bone mineral density QTL 8 1 4.9 35891 D1Rat19 41498 D1Rat266 Bone mineral density femoral neck trabecular vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 1 43872710 88872710 4 - by one flank marker only 1 43875655 88875655 4 - by one flank marker only 60994;60999 F344;LEW
1578650 rat Bmd6 Bone mineral density QTL 6 1 12.2 41058 D1Rat245 38782 D1Rat136 Bone mineral density femoral neck total vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 1 390736 37647484 1 - by flanking markers 1 574288 37650429 1 - by flanking markers 60994;60999 F344;LEW
1578651 rat Bmd7 Bone mineral density QTL 7 1 14.2 41058 D1Rat245 38782 D1Rat136 Bone mineral density femoral neck cortical vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 1 390736 37647484 1 - by flanking markers 1 574288 37650429 1 - by flanking markers 60994;60999 F344;LEW
1578652 rat Bmd15 Bone mineral density QTL 15 7 5.2 37262 D7Rat64 38198 D7Rat69 Bone mineral density femoral neck trabecular vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307;2293187 16461031;17907919 7 11379354 64612195 1 - by flanking markers 7 11379355 64632925 1 - by flanking markers 60994;60999 F344;LEW
1578653 rat Vnigr3 Vascular neointimal growth QTL 3 3 3.1 11278 D3Arb12 Vascular neointimal growth after injury blood vessel neointimal area A model for neointimal formation after vascular injury was created by surgery in 11-12 week old rats in which the femoral artery was exposed and cannulated with a balloon catheter, which was inflated three times for a standard vascular injury protocol. Eight weeks after injury, femoral arteries were dissected and several cross-sectional measurements recorded, including medial area (MA), neointimal area (NIH), lumen size (LS) internal elastic lamina (IEL) length, and used to calculate percent of total arterial wall area due to neointimal growth vascular smooth muscle cell hyperplasia;artery occlusion Hyperplasia 1578306;2316923 16434542;20026763 3 132947812 171063335 3 - by peak only 3 132853848 170969371 3 - by peak only 10008;724574 BN/SsNHsd;SHR/NHsd
1578654 rat Bss10 Bone structure and strength QTL 10 1 4.0 35891 D1Rat19 37092 D1Rat52 Bone structure femoral neck cortical area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 1 43872710 162735928 1 - by flanking markers 1 43875655 162831405 1 - by flanking markers 60994;60999 F344;LEW
1578655 rat Bmd11 Bone mineral density QTL 11 4 11.0 41458 D4Rat153 41616 D4Rat193 Bone mineral density femoral neck total vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307;2300256 16461031;18728226 4 93201451 138201451 4 - by one flank marker only 4 42637314 138446292 1 - by flanking markers 60994;60999 F344;LEW
1578656 rat Vnigr2 Vascular neointimal growth QTL 2 3 4.2 11278 D3Arb12 Vascular neointimal growth after injury blood vessel lumen size A model for neointimal formation after vascular injury was created by surgery in 11-12 week old rats in which the femoral artery was exposed and cannulated with a balloon catheter, which was inflated three times for a standard vascular injury protocol. Eight weeks after injury, femoral arteries were dissected and several cross-sectional measurements recorded, including medial area (MA), neointimal area (NIH), lumen size (LS) internal elastic lamina (IEL) length, and used to calculate percent of total arterial wall area due to neointimal growth Hyperplasia 1578306 16434542 3 132947812 171063335 3 - by peak only 3 132853848 170969371 3 - by peak only 10008;724574 BN/SsNHsd;SHR/NHsd
1578657 rat Bss12 Bone structure and strength QTL 12 4 8.9 37378 D4Rat123 39916 D4Rat175 Bone structure femoral neck total area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307;2300256 16461031;18728226 4 61483655 106483655 4 - by one flank marker only 60994;60999 F344;LEW
1578658 rat Bss13 Bone structure and strength QTL 13 4 8.0 37378 D4Rat123 39916 D4Rat175 Bone structure femoral neck polar moment of inertia (Ip) At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307;2300256 16461031;18728226 4 61483655 106483655 4 - by one flank marker only 60994;60999 F344;LEW
1578659 rat Tspe1 Trichinella spiralis expulsion QTL 1 9 4.8 11.0 34815 D9Rat16 35843 D9Rat13 35172 D9Rat19 Host defense expulsion of intestinal worms Host response to infection by the intestinal nemotode parasite Trichinella spiralis was measured by the capacity to expel adult worms after a primary infection. Rats were fed 2,000 T. spiralis larvae and killed 10 days later,intestines transfered to PBS solution, and contents examined by stereoscopic observation. The number of adult worms recovered from each animal was recorded decreased susceptibility to parasitic infection Intestinal Diseases, Parasitic;Nematode Infections 1578305 16465509 2299;620123 Cd28;Icos 9 58516719 62957638 1 - by flanking markers 9 58663702 63104620 1 - by flanking markers 61111;1302627 DA/Slc;F344/NSlc
1578660 rat Bss19 Bone structure and strength QTL 19 15 4.3 41564 D15Rat80 40516 D15Rat106 Bone structure femoral neck trabecular area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 15 25506124 106177917 1 - by flanking markers 15 25521824 106193697 1 - by flanking markers 60994;60999 F344;LEW
1578661 rat Bss20 Bone structure and strength QTL 20 18 3.7 37578 D18Rat65 39278 D18Rat44 Bone structure femoral neck total area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 18 12245097 86863411 1 - by flanking markers 18 12271744 86936861 1 - by flanking markers 60994;60999 F344;LEW
1578662 rat Bss15 Bone structure and strength QTL 15 4 19.6 37378 D4Rat123 35070 D4Rat57 Bone structure femoral neck width At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307;2300256 16461031;18728226 4 89539438 134539438 4 - by one flank marker only 60994;60999 F344;LEW
1578663 rat Bss18 Bone structure and strength QTL 18 10 3.6 38542 D10Rat132 35254 D10Rat2 Bone structure femoral neck width At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 10 101222719 110718848 4 - by one flank marker only 10 101237090 110733352 4 - by one flank marker only 60994;60999 F344;LEW
1578664 rat Bmd9 Bone mineral QTL density 9 2 5.0 36912 D2Rat1 38950 D2Rat173 Bone mineral density femoral neck total vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 2 9670332 49013509 1 - by flanking markers 2 9594136 48941769 1 - by flanking markers 60994;60999 F344;LEW
1578665 rat Bss16 Bone structure and strength QTL 16 6 4.4 38006 D6Rat69 35140 D6Rat22 Bone structure femoral neck trabecular area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 6 6265856 75462111 1 - by flanking markers 6 6265856 75465237 1 - by flanking markers 60994;60999 F344;LEW
1578666 rat Vnigr1 Vascular neointimal growth QTL 1 3 4.6 41210 D3Rat145 36745 D3Rat1 11278 D3Arb12 Vascular neointimal growth after injury blood vessel circular area A model for neointimal formation after vascular injury was created by surgery in 11-12 week old rats in which the femoral artery was exposed and cannulated with a balloon catheter, which was inflated three times for a standard vascular injury protocol. Eight weeks after injury, femoral arteries were dissected and several cross-sectional measurements recorded, including medial area (MA), neointimal area (NIH), lumen size (LS) internal elastic lamina (IEL) length, and used to calculate percent of total arterial wall area due to neointimal growth Hyperplasia 1578306 16434542 3 151160532 170016653 1 - by flanking markers 3 151066442 169922503 1 - by flanking markers 10008;724574 BN/SsNHsd;SHR/NHsd
1578667 rat Bss21 Bone structure and strength QTL 21 18 3.5 37578 D18Rat65 39278 D18Rat44 Bone structure femoral neck cortical area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 18 12245097 86863411 1 - by flanking markers 18 12271744 86936861 1 - by flanking markers 60994;60999 F344;LEW
1578668 rat Bmd14 Bone mineral density QTL 14 6 3.8 38006 D6Rat69 35140 D6Rat22 Bone mineral density femoral neck total vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 6 6265856 75462111 1 - by flanking markers 6 6265856 75465237 1 - by flanking markers 60994;60999 F344;LEW
1578669 rat Bss9 Bone structure and strength QTL 9 1 6.3 41058 D1Rat245 38782 D1Rat136 Bone structure femoral neck trabecular area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 1 390736 37647484 1 - by flanking markers 1 574288 37650429 1 - by flanking markers 60994;60999 F344;LEW
1578670 rat Bss14 Bone structure and strength QTL 14 4 16.4 37378 D4Rat123 35070 D4Rat57 Bone structure femoral neck trabecular area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307;2300256 16461031;18728226 4 89539438 134539438 4 - by one flank marker only 60994;60999 F344;LEW
1578671 rat Bmd10 Bone mineral density QTL 10 2 5.4 36912 D2Rat1 35915 D2Rat61 Bone mineral density femoral neck cortical vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307;2293187 16461031;17907919 2 9670332 227150248 1 - by flanking markers 2 9594136 227136928 1 - by flanking markers 60994;60999 F344;LEW
1578672 rat Bmd16 Bone mineral density QTL 16 10 6.2 38542 D10Rat132 35254 D10Rat2 Bone mineral density femoral neck cortical vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 10 101222719 110718848 4 - by one flank marker only 10 101237090 110733352 4 - by one flank marker only 60994;60999 F344;LEW
1578673 rat Bmd13 Bone mineral density QTL 13 5 4.9 41560 D5Rat153 39600 D5Rat154 Bone mineral density femoral neck trabecular vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 5 108590295 153590295 4 - by one flank marker only 5 108595522 153595522 4 - by one flank marker only 60994;60999 F344;LEW
1578674 rat Bmd12 Bone mineral density QTL 12 4 3.8 41458 D4Rat153 37340 D4Rat84 Bone mineral density femoral neck cortical vBMD At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area increased bone mineral density Osteoporosis 1578307 16461031 4 140398530 185398530 4 - by one flank marker only 4 42637314 185643654 1 - by flanking markers 60994;60999 F344;LEW
1578675 rat Bss17 Bone structure and strength QTL 17 9 3.8 37468 D9Rat162 35623 D9Rat41 Bone structure femoral neck cortical area At 26 weeks of age, female rats were euthanized, femurs and spleen removed, bone mineral density and bone structure phenotypes were measured as follows: volumetric BMD (vBMD), polar moment of inertia (Ip; mm4), total vBMD, cortical vBMD, trabecular vBMD, total area, cortical area, trabecular area abnormal bone structure Osteoporosis 1578307 16461031 9 4796492 8991332 1 - by flanking markers 9 4796487 8988654 1 - by flanking markers 60994;60999 F344;LEW
1579915 rat Bp280 Blood pressure QTL 280 10 0.001 37150 D10Rat204 36958 D10Rat9 Blood pressure mean arterial pressure male rats were fed a high-salt diet (2% NaCl) starting at day 35. At day 56, telemetry probes were implanted and systolic, diastolic and mean arterial blood pressures measured increased mean systemic arterial blood pressure;decreased systemic arterial systolic blood pressure Hypertension;Hypotension 1601352;1599557;1559293 17420333;17143582;16286573 10 94837236 99588446 1 - by flanking markers 10 94851606 99602816 1 - by flanking markers 1579894;1579903 SS.LEW-(D10Rat204-D10Rat9)/Ayd;SS.LEW-(D10Rat13-D10Rat11)/Ayd
1579916 rat Bp270 Blood pressure QTL 270 2 0.003 1579094 D2Chm277 3407 Prlr Blood pressure mean arterial at 35 days of age, male rats were fed a high salt diet (2% NaCl). At 56 days of age, telemetry probes were implanted and rats were given 10 days to recuperate before blood pressure measurements were taken increased mean systemic arterial blood pressure Hypertension 1599557;1358142 17143582;15827238 2 14701221 59701221 4 - by one flank marker only 2 14629454 59629454 4 - by one flank marker only 1549794;1549795;1549808;1579896 SS.LEW-(D2Rat199-D2Mco17)/Ayd;SS.LEW-(D2Rat199-D2Rat143)/Ayd;SS.LEW-(Prlr-D2Rat143)/Ayd;SS.LEW-(D2Rat18-D2Chm277)/Ayd
1579917 rat Bp282 Blood pressure QTL 282 10 0.001 1579039 D10Chm169 1578994 D10Chm147 Blood pressure mean arterial male rats were fed a high-salt diet (2% NaCl) starting at day 35. At day 56, telemetry probes were implanted and systolic, diastolic and mean arterial blood pressures measured decreased systemic arterial systolic blood pressure Hypotension 1559293 16286573 724572;1579898;1579907 SS.LEW-(D10Wox51-D10Rat27)/Ayd;SS.LEW-(D10Chm128-D10Chm182)/Ayd;SS.LEW-(D10Chm128-D10Chm169)/Ayd
1579918 rat Bp279 Blood pressure QTL 279 10 0.01 1578850 D10Chm212 1578891 D10Chm29 Blood pressure mean arterial pressure male rats were fed a high-salt diet (2% NaCl) starting at day 35. At day 56, telemetry probes were implanted and systolic, diastolic and mean arterial blood pressures measured. decreased systemic arterial systolic blood pressure Hypotension 1559293 16286573 724572;1579901;1579913 SS.LEW-(D10Wox51-D10Rat27)/Ayd;SS.LEW-(D10Chm224-D10Chm6)/Ayd;SS.LEW-(D10Chm224-D10Chm222)/Ayd
1579919 rat Bp281 Blood pressure QTL 281 10 0.01 44776 D10Got92 37996 D10Rat127 Blood pressure mean arterial pressure male rats were fed a high-salt diet (2% NaCl) starting at day 35. At day 56, telemetry probes were implanted and systolic, diastolic and mean arterial pressures were measured. decreased systemic arterial systolic blood pressure;abnormal aortic weight;increased mean systemic arterial blood pressure Hypotension;Hypertension 1599557;1559293 17143582;16286573 10 77956239 87272656 1 - by flanking markers 10 77970610 87287010 1 - by flanking markers 724577;1579914 SS.LEW-(D10Rat27-Igfbp4)/Ayd;SS.LEW-(D10Mco30-D10Got92)/Ayd
1598805 rat Memor8 Memory QTL 8 2 3.0 33747 D2Mit10 10200 D2Mgh11 1303105 Dear Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation, quantitative trait of index of spatial accuracy (SpA) defined as the average distance from the platform on the probe trial abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581615 16837653 2 155920709 197555821 2 - by one flank and peak markers 2 155870673 197504827 2 - by one flank and peak markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598807 rat Glom12 Glomerulus QTL 12 5 2.7 33678 D5Mit10 Renal pathology glomerular injury score total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with renal disease, measured as glomerular injury score (GIS) in which glomeruli were analysed for degree of mesengial matrix expansion and glomerulosclerosis abnormal mesangial cell Kidney Diseases;Glomerulosclerosis, Focal 1581737 16720678 5 35474610 80474610 3 - by peak only 5 35474789 80474789 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598809 rat Memor15 Memory QTL 15 X 4.4 40522 DXRat98 34783 DXRat21 Memory social recognition genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped for a social recognition task in which social-investigatory behavior time was analyzed from a videotaped test after initial exposure to a a juvenile rat introduced as social stimulus; quantitative trait of social recognition memory defined as the difference (in seconds) between the sample phase and test phase abnormal learning/ memory;abnormal social investigation Memory Disorders;Learning Disorders 1581615 16837653 X 9007287 160699376 2 - by one flank and peak markers X 9012843 160775580 2 - by one flank and peak markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598811 rat Bp291 Blood pressure QTL 291 11 1.9 34150 D11Mgh5 Blood pressure systolic total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry decreased systemic arterial systolic blood pressure Hypotension 1581737 16720678 11 20656936 65656936 3 - by peak only 11 20714526 65714526 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598813 rat Memor9 Memory QTL 9 2 2.7 39040 D2Rat169 34864 D2Rat67 35613 D2Rat59 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation, quantitative trait of index of spatial accuracy (SpA) defined as the average distance from the platform on the probe trial abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581615 16837653 2 207443643 243502158 1 - by flanking markers 2 207406398 243488898 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598814 rat Mcs13 Mammary carcinoma susceptibility QTL 13 5 1.0E-4 1581996 D5Uwm65 1582030 D5Uwm66 Mammary tumor susceptibility female rats at age 50 to 55 days were administered a single dose (65mg/kg)of 7,12-dimethylbenz[a]anthracene (DMBA) in sesame oil by gastric intubation. At 15 weeks, mammary carcinomas of >3x3mm were counted. 1559294 16266982 1581627;1581632 WF.WKY-(D5Uwm66-D5Uwm67)/Uwm;WF.WKY-(D5Uwm65-D5Uwm60)/Uwm
1598816 rat Memor12 Memory QTL 12 20 2.4 37792 D20Rat29 38836 D20Rat37 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation, quantitative trait of index of spatial accuracy (SpA) defined as the average distance from the platform on the probe trial abnormal spatial learning;abnormal object recognition memory Memory Disorders;Learning Disorders 1581615 16837653 20 3055886 48055886 4 - by one flank marker only 20 3084583 48084583 4 - by one flank marker only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598817 rat Glom13 Glomerulus QTL 13 1 2.2 11201 D1Mgh11 Renal pathology glomerular injury score total genome scan of F2 animals on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with renal disease, measured as glomerular injury score (GIS) in which glomeruli were analysed for degree of mesengial matrix expansion and glomerulosclerosis abnormal mesangial cell Kidney Diseases;Glomerulosclerosis, Focal 1581737 16720678 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598819 rat Bp292 Blood pressure QTL 292 5 4.3 38916 D5Rat106 Blood pressure systolic total genome scan of F2 females on high salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 5 134356746 173096209 3 - by peak only 5 134366785 173106704 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598821 rat Rf55 Renal function QTL 55 1 6.3 36866 D1Rat73 36169 D1Rat89 41680 D1Rat376 Renal function renal blood flow genetic linkage analysis on F2 rats for autoregulation of renal blood flow (RBF) as measured by an autoregulation index (AI) of 0 to 1 where an AI = 0 indicates perfect RBF autoregulation AI =1 indicates circulation with fixed vascular resistance 1579884 16303858 1 224420592 265343617 1 - by flanking markers 1 224584615 265554662 1 - by flanking markers 629509;629520 FHH/EurMcwi;FHH-Chr 1BN/Mcwi intercross
1598823 rat Memor16 Memory QTL 16 9 1.9 40022 D9Rat152 39362 D9Rat92 37604 D9Rat76 Memory social recognition genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped for a social recognition task in which social-investigatory behavior time was analyzed from a videotaped test after initial exposure to a a juvenile rat introduced as social stimulus; quantitative trait of social recognition memory defined as the difference (in seconds) between the sample phase and test phase abnormal learning/ memory;abnormal social investigation Memory Disorders;Learning Disorders 1581615 16837653 9 18410299 47035878 1 - by flanking markers 9 18407621 47037292 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598824 rat Memor4 Memory QTL 4 8 2.5 33628 D8Mit6 41026 D8Rat153 36673 D8Rat49 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation; quantitative trait of index of spatial aquisition performance ACQ TD defined as the cumulative distance traveled over 24 trials abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581615 16837653 8 9581132 56397678 1 - by flanking markers 8 9581132 56416732 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598826 rat Anxrr20 Anxiety related response QTL 20 18 3.04 36638 D18Rat14 Anxiety response open field test- rearing genome wide scan of F2 animals for anxiety/emotionality measured by rearing and other behavioral responses in open field (OFT) and defensive burying (DB) tests 1578499 16490266 18 44524337 87265094 3 - by peak only 18 0 23604844 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1598828 rat Glom14 Glomerulus QTL 14 15 2.5 40554 D15Rat93 Renal pathology glomerular injury score total genome scan of F2 females on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with renal disease, measured as glomerular injury score (GIS) in which glomeruli were analysed for degree of mesengial matrix expansion and glomerulosclerosis abnormal mesangial cell Kidney Diseases;Glomerulosclerosis, Focal 1581737 16720678 15 40091127 85091127 3 - by peak only 15 40106848 85106848 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598830 rat Bp288 Blood pressure QTL 288 1 3.5 11201 D1Mgh11 Blood pressure systolic total genome scan of F2 animals on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598832 rat Glom11 Glomerulus QTL 11 18 2.9 40918 D18Rat80 Renal pathology glomerular injury score total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with renal disease, measured as glomerular injury score (GIS) in which glomeruli were analysed for degree of mesengial matrix expansion and glomerulosclerosis abnormal mesangial cell Kidney Diseases;Glomerulosclerosis, Focal 1581737 16720678 18 54435837 87265094 3 - by peak only 18 54509110 87338544 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598833 rat Bp295 Blood pressure QTL 295 2 3.5 1303105 Dear Blood pressure systolic total genome scan of F2 females on high salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 2 154238265 199238265 3 - by peak only 2 154187750 199187750 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598834 rat Memor11 Memory QTL 11 9 2.5 37604 D9Rat76 33999 D9Mit5 39362 D9Rat92 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation, quantitative trait of index of spatial accuracy (SpA) defined as the average distance from the platform on the probe trial abnormal spatial learning;abnormal object recognition memory Memory Disorders;Learning Disorders 1581615 16837653 620218 Creb1 9 33496794 75633613 1 - by flanking markers 9 33498209 75798798 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598835 rat Anxrr18 Anxiety related response QTL 18 2 2.98 39118 D2Rat139 Anxiety response defensive burying- rearing genome wide scan of F2 animals for anxiety/emotionality measured by rearing and other behavioral responses in open field (OFT) and defensive burying (DB) tests 1578499 16490266 2 210033012 255033012 3 - by peak only 2 210019753 255019753 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1598837 rat Memor13 Memory QTL 13 X 3.2 36952 DXRat11 36735 DXRat32 Memory social recognition genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped for a social recognition task in which social-investigatory behavior time was analyzed from a videotaped test after initial exposure to a a juvenile rat introduced as social stimulus; quantitative trait of social recognition memory defined as the difference (in seconds) between the sample phase and test phase abnormal learning/ memory;abnormal social investigation Memory Disorders;Learning Disorders 1581615 16837653 X 62691290 160699376 2 - by one flank and peak markers X 62744759 160775580 2 - by one flank and peak markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598838 rat Bp290 Blood pressure QTL 290 2 1.9 10200 D2Mgh11 Blood pressure systolic total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598839 rat Rf56 Renal function QTL 56 1 10805 D1Mgh13 36169 D1Rat89 Renal function renal blood flow congenic strain mapping to identify a minimal region for autoregulation of renal blood flow (RBF) as measured by an autoregulation index (AI) of 0 to 1 where AI = 0 indicates perfect RBF autoregulation and AI =1 indicates circulation with fixed vascular resistance 1579884 16303858 1 252340389 265343617 1 - by flanking markers 1 252604962 265554662 1 - by flanking markers 1582186;1582191;1582193;1582195;1582196 FHH.FHH.1BN-(D1Rat183-D1Rat76)/Mcwi;FHH.FHH.1BN-(D1Rat287-D1Rat84)/Mcwi;FHH.FHH.1BN-(D1Mgh13-D1Rat89)/Mcwi;FHH.FHH.1BN-(D1Rat173F6B-D1Rat84)/Mcwi;FHH.FHH.1BN-(D1Rat234-D1Rat265)/Mcwi
1598841 rat Memor7 Memory QTL 7 11 34150 D11Mgh5 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation; quantitative trait of index of spatial aquisition performance ACQ TD defined as the cumulative distance traveled over 24 trials abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581615 16837653 11 20656936 65656936 3 - by peak only 11 20714526 65714526 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598842 rat Glom10 Glomerulus QTL 10 11 3.4 41734 D11Rat101 Renal pathology glomerular injury score total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with renal disease, measured as glomerular injury score (GIS) in which glomeruli were analysed for degree of mesengial matrix expansion and glomerulosclerosis abnormal mesangial cell Kidney Diseases;Glomerulosclerosis, Focal 1581737 16720678 11 1 35465693 3 - by peak only 11 0 35465693 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598843 rat Cm63 Cardiac mass QTL 63 6 2.6 37142 D6Rat80 Cardiac mass total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with increased cardiac mass (relative heart weight to body weight ratio measured at 20 weeks) decreased heart weight Hypotension;Cardiomegaly 1581737 16720678 6 1 23802078 3 - by peak only 6 0 23802078 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598845 rat Mcs14 Mammary carcinoma susceptibility QTL 13 5 1.0E-4 1582044 D5Uwm67 1582002 D5Uwm61 Mammary tumor susceptibility female rats at age 50 to 55 days were administered a single dose (65mg/kg)of 7,12-dimethylbenz[a]anthracene (DMBA) in sesame oil by gastric intubation. At 15 weeks, mammary carcinomas of >3x3mm were counted. 1559294 16266982 1581631;1581641 WF.WKY-(D5Uwm61-D5Uwm37)/Uwm;WF.WKY-(D5Uwm68-D5Mit4)/Uwm
1598846 rat Bp293 Blood pressure QTL 293 5 3.9 35074 D5Rat23 Blood pressure systolic total genome scan of F2 females on high salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 621139 Bsnd 5 84392127 129392127 3 - by peak only 5 84397353 129397353 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598847 rat Cm62 Cardiac mass QTL 62 5 3.4 33680 D5Mit13 Cardiac mass total genome scan of F2 animals on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with increased cardiac mass (relative heart weight to body weight ratio measured at 20 weeks) increased heart weight Hypertension;Cardiomegaly 1581737 16720678 5 115772027 160772027 3 - by peak only 5 115777253 160777253 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598849 rat Memor17 Memory QTL 17 9 2.2 39362 D9Rat92 36556 D9Rat10 33999 D9Mit5 Memory social recognition genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped for a social recognition task in which social-investigatory behavior time was analyzed from a videotaped test after initial exposure to a a juvenile rat introduced as social stimulus; quantitative trait of social recognition memory defined as the difference (in seconds) between the sample phase and test phase abnormal learning/ memory;abnormal social investigation Memory Disorders;Learning Disorders 1581615 16837653 9 47035692 68493058 1 - by flanking markers 9 47037106 68640040 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598850 rat Bp297 Blood pressure QTL 297 1 2.1 34868 D1Rat45 Blood pressure systolic total genome scan of F2 animals on high salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 1 123689796 168689796 3 - by peak only 1 123768170 168768170 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598852 rat Anxrr19 Anxiety related response QTL 19 10 5.07 39038 D10Rat104 Anxiety response open field test- rearing genome wide scan of F2 animals for anxiety/emotionality measured by rearing and other behavioral responses in open field (OFT) and defensive burying (DB) tests 1578499 16490266 additive 10 19468218 64468218 3 - by peak only 10 19481734 64481734 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd
1598853 rat Memor3 Memory QTL 3 1 4.5 34868 D1Rat45 35525 D1Rat116 37184 D1Rat188 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation; quantitative trait of index of spatial aquisition performance ACQ TD defined as the cumulative distance traveled over 24 trials abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581615 16837653 1 146189650 218467340 1 - by flanking markers 1 146268095 218631363 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598854 rat Memor10 Memory QTL 10 3 2.0 36584 D3Rat6 36759 D3Rat59 41322 D3Rat137 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation, quantitative trait of index of spatial accuracy (SpA) defined as the average distance from the platform on the probe trial abnormal spatial learning;abnormal object recognition memory Memory Disorders;Learning Disorders 1581615 16837653 3 147990566 163443738 1 - by flanking markers 3 147896437 163349774 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598855 rat Bp294 Blood pressure QTL 294 12 3.5 33911 D12Mit6 Blood pressure systolic total genome scan of F2 females on high salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 12 1 35270263 3 - by peak only 12 0 35300192 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598856 rat Memor1 Memory QTL 1 X 1.9 40522 DXRat98 34783 DXRat21 Memory navigation-spatial linkage analysis of F2 males to identify X chromosome QTL influencing spatial learning and memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation; quantitative trait of index of spatial aquisition performance ACQ TD defined as the cumulative distance traveled over 24 trials abnormal spatial learning;abnormal object recognition memory Memory Disorders;Learning Disorders 1581736;1581615 14665699;16837653 X 9007287 160699376 2 - by one flank and peak markers X 9012843 160775580 2 - by one flank and peak markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598858 rat Cm61 Cardiac mass QTL 61 20 3.6 38836 D20Rat37 Cardiac mass total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with increased cardiac mass (relative heart weight to body weight ratio measured at 20 weeks) increased heart weight Hypertension;Cardiomegaly 1581737 16720678 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598859 rat Cm66 Cardiac mass QTL 66 5 2.0 35074 D5Rat23 Cardiac mass total genome scan of F2 females for QTL influencing salt-sensitive hypertension susceptibility associated with increased cardiac mass (relative heart weight to body weight ratio measured at 20 weeks) increased heart weight Hypertension;Cardiomegaly 1581737 16720678 5 84392127 129392127 3 - by peak only 5 84397353 129397353 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598861 rat Cm64 Cardiac mass QTL 64 5 2.9 38916 D5Rat106 Cardiac mass total genome scan of F2 animals on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with increased cardiac mass (relative heart weight to body weight ratio measured at 20 weeks) increased heart weight Hypertension;Cardiomegaly 1581737 16720678 5 134356746 173096209 3 - by peak only 5 134366785 173106704 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598862 rat Glom9 Glomerulus QTL 9 2 3.5 38362 D2Rat161 Renal pathology glomerular injury score total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with renal disease, measured as glomerular injury score (GIS) in which glomeruli were analysed for degree of mesengial matrix expansion and glomerulosclerosis abnormal mesangial cell Kidney Diseases;Glomerulosclerosis, Focal 1581737 16720678 2 95764665 140764665 3 - by peak only 2 95709538 140709538 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598863 rat Cm65 Cardiac mass QTL 65 2 2.3 38362 D2Rat161 Cardiac mass total genome scan of F2 females on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility associated with increased cardiac mass (relative heart weight to body weight ratio measured at 20 weeks) increased heart weight Hypertension;Cardiomegaly 1581737 16720678 2 95764665 140764665 3 - by peak only 2 95709538 140709538 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598865 rat Bp296 Blood pressure QTL 296 2 2.1 38610 D2Rat143 Blood pressure systolic total genome scan of F2 females on high salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 2 83736075 128736075 3 - by peak only 2 83681037 128681037 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598866 rat Bp287 Blood pressure QTL 287 1 5.1 34868 D1Rat45 Blood pressure systolic total genome scan of F2 animals on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure is measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 1 123689796 168689796 3 - by peak only 1 123768170 168768170 3 - by peak only 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598868 rat Mcs12 Mammary carcinoma susceptibility QTL 12 5 1.0E-4 1581988 D5Uwm62 1582038 D5Uwm64 Mammary tumor susceptibility female rats at age 50 to 55 days were administered a single dose (65mg/kg)of 7,12-dimethylbenz[a]anthracene (DMBA) in sesame oil by gastric intubation. At 15 weeks, mammary carcinomas of >3x3mm were counted. 1601189;1559294 17404222;16266982 1581629;1581630 WF.WKY-(D5Wox8-D5Uwm62)/Uwm;WF.WKY-(D5Uwm63-D5Uwm64)/Uwm
1598869 rat Memor6 Memory QTL 6 20 3.1 38180 D20Rat27 37792 D20Rat29 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation; quantitative trait of index of spatial aquisition performance ACQ TD defined as the cumulative distance traveled over 24 trials abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581615 16837653 20 28656553 55268282 2 - by one flank and peak markers 20 28670353 55296979 2 - by one flank and peak markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598870 rat Bp289 Blood pressure QTL 289 20 2.4 38836 D20Rat37 Blood pressure systolic total genome scan of F2 males on high-salt diet for QTL influencing salt-sensitive hypertension susceptibility; systolic blood pressure was measured by intra-aortic abdominal nonstress radiotelemetry increased systemic arterial systolic blood pressure Hypertension 1581737 16720678 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598871 rat Memor5 Memory QTL 5 17 5.3 37402 D17Rat78 10348 D17Mit4 Memory navigation-spatial genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation; quantitative trait of index of spatial aquisition performance ACQ TD defined as the cumulative distance traveled over 24 trials abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581615 16837653 2402 Crem 17 47628673 94800809 2 - by one flank and peak markers 17 47631514 94819634 2 - by one flank and peak markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598872 rat Memor14 Memory QTL 14 X 4.5 36735 DXRat32 40522 DXRat98 Memory social recognition genome wide scan on F2 males to identify QTL influencing spatial navigation and social recognition memory; animals were phenotyped for a social recognition task in which social-investigatory behavior time was analyzed from a videotaped test after initial exposure to a a juvenile rat introduced as social stimulus; quantitative trait of social recognition memory defined as the difference (in seconds) between the sample phase and test phase abnormal learning/ memory;abnormal social investigation Memory Disorders;Learning Disorders 1581615 16837653 X 1 118123026 2 - by one flank and peak markers X 0 118196309 2 - by one flank and peak markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1598873 rat Memor2 Memory QTL 2 X 2.5 36111 DXRat8 36952 DXRat11 35331 DXRat25 Memory navigation-spatial linkage analysis of F2 males to identify X chromosome QTL influencing spatial learning and memory; animals were phenotyped using the Morris water maze (MWM) test of spatial navigation, quantitative trait of index of spatial accuracy (SpA) defined as the average distance from the platform on the probe trial abnormal object recognition memory;abnormal spatial learning Memory Disorders;Learning Disorders 1581736;1581615 14665699;16837653 X 41386788 62691410 1 - by flanking markers X 41440348 62744879 1 - by flanking markers 1582184;1582190 SR/JrHsd;SS/JrHsd intercross
1600384 rat Niddm66 Non-insulin dependent diabetes mellitus QTL 66 1 5.0E-6 9.6 1600324 D1Swe8 43448 D1Got251 10097 D1Smu2 Glucose level postprandial glucose tolerance test (IPGTT) increased circulating glucose level Hyperglycemia;Diabetes Mellitus, Non-Insulin-Dependent 1599587;2316628 16951059;19965390 additive 1 215641846 260641846 4 - by one flank marker only 1 215852891 260852891 4 - by one flank marker only 1600342;1600344 F344.GK-(D1Got250-D1Rat90)/Swe;F344.GK-(D1Rat175-D1Rat90)/Swe
1600386 rat Calcic2 Intracellular calcium level QTL 2 12 0.001 34729 D12Mgh5 34373 D12Mgh6 Intracellular calcium level thrombin-stimulated intracellular calcium cations cardiac hypertrophy Hypotension 1599588 17261463 2174 Atp2a2 12 29130180 46782294 4 - by one flank marker only 12 28993569 46649226 4 - by one flank marker only 1600338 SHR.F344-(D12Mgh5-D12Mgh6)/Snk
1600388 rat Niddm67 Non-insulin dependent diabetes mellitus QTL 67 1 5.84 4.0E-6 19.0 43370 D1Wox8 43454 D1Got254 11060 D1Wox23 Glucose level intravenous glucose tolerance test 1598974 16783636 1 200882874 264367394 1 - by flanking markers 1 201032867 264578439 1 - by flanking markers 10017;737972 GK/KyoSwe;BN/Crl intercross
1600390 rat Niddm64 Non-insulin dependent diabetes mellitus QTL 64 1 0.003 4.0 43443 D1Got247 1600322 D1Swe3 1600318 D1Swe2 Glucose level postprandial glucose tolerance test (IPGTT) increased circulating glucose level Hyperglycemia;Diabetes Mellitus, Non-Insulin-Dependent 1599587 16951059 1310974 Sorcs3 1 254291806 267910886 4 - by one flank marker only 1 254556550 268121971 4 - by one flank marker only 1600344;1600345 F344.GK-(D1Rat175-D1Rat90)/Swe;F344.GK-(D1Rat83-D1Rat376)/Swe
1600391 rat Edcs2 Endometrial carcinoma susceptibility QTL2 12 3.5 0.01 34268 D12Mgh4 41956 D12Arb13 33911 D12Mit6 Endometrial tumor susceptibility onset of tumor development endometrial carcinoma Carcinoma, Endometrioid;Endometrial Neoplasms 1599853;1599856 15796960;11745480 2559;3124 Epo;Muc3a 12 7382953 27853771 1 - by flanking markers 12 7412881 27716957 1 - by flanking markers 737945;737947 BN/Han;BDII/Ztm intercross
1600392 rat Niddm63 Non-insulin dependent diabetes mellitus QTL 63 1 0.001 5.1 34935 D1Rat83 37398 D1Rat175 34935 D1Rat83 Body weight body weight was taken decreased body weight Diabetes Mellitus, Non-Insulin-Dependent 1599587 16951059 additive 1 229633779 267910886 3 - by peak only 1 229896889 268121971 3 - by peak only 1600345 F344.GK-(D1Rat83-D1Rat376)/Swe
1600394 rat Edcs1 Endometrial carcinoma susceptibility QTL1 11 2.9 34130 D11Mgh6 33899 D11Mit4 Endometrial tumor susceptibility onset of tumor development endometrial carcinoma Endometrial Neoplasms;Carcinoma, Endometrioid 1599853;1599856 15796960;11745480 2139;1584977 App;Ets2 11 19445919 24982397 2 - by one flank and peak markers 11 19445919 24982397 2 - by one flank and peak markers 737947;737962 BDII/Ztm;SPRD/HanZtm intercross
1600395 rat Niddm69 Non-insulin dependent diabetes mellitus QTL 69 1 4.14 2.0E-4 13.0 43370 D1Wox8 43454 D1Got254 70473 D1M19Mit11 Insulin level insulin secretion test (IVGTT) 1598974 16783636 1 200882874 264367394 1 - by flanking markers 1 201032867 264578439 1 - by flanking markers 10017;737972 GK/KyoSwe;BN/Crl intercross
1600396 rat Niddm68 Non-insulin dependent diabetes mellitus QTL 68 1 4.97 3.0E-4 13.0 43370 D1Wox8 43454 D1Got254 10580 D1Smu5 Glucose level intravenous glucose tolerance test 1598974 16783636 1 200882874 264367394 1 - by flanking markers 1 201032867 264578439 1 - by flanking markers 1600339 BN.GK-(D1Wox18-D1Got254)/Ox
1600397 rat Edcs4 Endometrial carcinoma susceptibility QTL 4 1 2.2 33646 D1Mit4 10674 D1Mgh12 40028 D1Rat301 Endometrial tumor susceptibility onset of tumor development endometrial carcinoma Endometrial Neoplasms;Carcinoma, Endometrioid 1599853;1599856 15796960;11745480 1 221868279 247322277 2 - by one flank and peak markers 1 222081850 247436752 2 - by one flank and peak markers 737947;737962 BDII/Ztm;SPRD/HanZtm intercross
1600398 rat Edcs5 Endometrial carcinoma susceptibility QTL 5 17 2.2 45485 D17Wox9 33707 D17Mit5 34120 D17Mgh5 Endometrial tumor susceptibility onset of tumor development endometrial carcinoma Endometrial Neoplasms;Carcinoma, Endometrioid 1599853;1599856 15796960;11745480 17 65900398 82125463 1 - by flanking markers 17 65911232 82136296 1 - by flanking markers 737947;737962 BDII/Ztm;SPRD/HanZtm backcross
1600399 rat Niddm65 Non-insulin dependent diabetes mellitus QTL 65 1 0.004 3.9 1600320 D1Swe4 41680 D1Rat376 60230 D1Got244 Glucose level postprandial glucose tolerance test (IPGTT) Diabetes Mellitus, Non-Insulin-Dependent 1599587 16951059 1305910 Sorcs1 1 233178490 267910886 3 - by peak only 1 233444406 268121971 3 - by peak only 1600344;1600345;1600346 F344.GK-(D1Rat175-D1Rat90)/Swe;F344.GK-(D1Rat83-D1Rat376)/Swe;F344.GK-(D1Swe4-D1Rat85)/Swe
1599689 rat Iddm24 Insulin dependent diabetes mellitus QTL 24 8 4.72 0.001 39624 D8Rat118 41446 D8Rat119 40246 D8Rat121 Glucose Level Insulin Dependent The animals became glycosuric (>5mmol/l), measured using Chemstrip test strips. Age to onset gave the highest LOD score insulitis;Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 1624306 17389329 8 120530821 123875958 1 - by flanking markers 8 120550558 123895808 1 - by flanking markers 1599674 BBDP.WF-(D8Rat59-D8Sunn1467)/Sunn
1641885 rat Alcrsp9 Alcohol response QTL 9 7 41106 D7Rat147 Alcohol response Blood ethanol concentration mean blood ethanol concentration increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439 15608595 7 27664404 72664404 3 - by peak only 7 27685176 72685176 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641887 rat Alcrsp14 Alcohol response QTL 14 15 36313 D15Rat5 Alcohol response neurotensin receptor binding assay increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439;1600610 15608595;16953387 15 1 44952804 3 - by peak only 15 0 44968504 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641889 rat Colcr6 Colorectal carcinoma resistance QTL 6 15 2.9 0.0126 34222 D15Mgh8 38178 D15Rat63 38178 D15Rat63 Colorectal carcinoma resistance surface area of colorectal adenoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 15 80361961 107849649 1 - by flanking markers 15 80377742 107865429 1 - by flanking markers 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641891 rat Alcrsp17 Alcohol response QTL 17 2 35162 D2Rat38 34858 D2Rat69 38054 D2Rat138 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance Alcohol-Induced Disorders 1600610;1334439 16953387;15608595 2 155101972 247295816 1 - by flanking markers 2 155052021 247310423 1 - by flanking markers 1641861 HAS.LAS-(D2Rat38-D2Rat69) intercross
1641893 rat Alcrsp7 Alcohol response QTL 7 20 38324 D20Rat32 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance;impaired righting response Alcohol-Induced Disorders 1334439 15608595 20 1 27477794 3 - by peak only 20 0 27478021 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641894 rat Alcrsp12 Alcohol response QTL 12 9 39362 D9Rat92 Alcohol response neurotensin receptor binding assay increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439;1600610 15608595;16953387 9 24535785 69535785 3 - by peak only 9 24537199 69537199 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641895 rat Bp298 Blood pressure QTL 298 1 60784 D1Wox29 11359 D1Arb21 Blood pressure mean arterial infarct volume after middle cerebral artery occlusion abnormal baroreceptor physiology;decreased mean systemic arterial blood pressure Hypotension;Myocardial Ischemia 1600255;2302408 17327494;19047583 1 124614679 187092492 1 - by flanking markers 1 124693023 187242373 1 - by flanking markers 1600343 SHRSP.WKY-(D1Wox29-D1Arb21)/Izm
1641897 rat Alcrsp1 Alcohol response QTL 1 1 36432 D1Rat35 Alcohol response loss of righting reflex loss of righting reflex test impaired righting response;increased sensitivity to addictive substance Ataxia;Alcohol-Induced Disorders 1334439;2317807 15608595;19500156 1 102248992 147248992 3 - by peak only 1 102327336 147327336 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641898 rat Colcr4 Colorectal carcinoma resistance QTL4 6 3.71 7.0E-4 35683 D6Rat39 40044 D6Rat154 41064 D6Rat134 Colorectal carcinoma resistance Colorectal adenoma surface area increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 6 33021033 64955579 2 - by one flank and peak markers 6 33024159 64958705 2 - by one flank and peak markers 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641900 rat Alcrsp11 Alcohol response QTL 11 14 39030 D14Rat38 Alcohol response Blood ethanol concentration mean blood ethanol concentration increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439;1600610 15608595;16953387 14 76579917 112194335 3 - by peak only 14 76599062 112220682 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641901 rat Alcrsp6 Alcohol response QTL 6 13 36506 D13Rat32 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance;impaired righting response Alcohol-Induced Disorders 1334439 15608595 13 55689252 100689252 3 - by peak only 13 55703498 100703498 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641902 rat Colcr7 Colorectal carcinoma resistance QTL 7 17 335.0 0.0044 35116 D17Rat53 38348 D17Rat59 35116 D17Rat53 Colorectal carcinoma resistance surface area of colorectal adenoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 17 7696509 27724805 1 - by flanking markers 17 7696509 27727646 1 - by flanking markers 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641903 rat Alcrsp3 Alcohol response QTL 3 5 39186 D5Rat70 Alcohol response loss of righting reflex loss of righting reflex test impaired righting response;increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439 15608595 5 13886258 58886258 3 - by peak only 5 13886437 58886437 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641904 rat Alcrsp4 Alcohol response QTL 4 6 35659 D6Rat18 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance;impaired righting response Alcohol-Induced Disorders 1334439 15608595 6 70874239 115874239 3 - by peak only 6 70877680 115877680 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641905 rat Colcr1 Colorectal carcinoma resistance QTL 1 4 4.3 3.0E-4 38118 D4Rat133 38908 D4Rat126 38118 D4Rat133 Colorectal carcinoma resistance surface area of colorectal adenoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 4 1 26178440 4 - by one flank marker only 4 0 26194337 4 - by one flank marker only 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641906 rat Alcrsp16 Alcohol response QTL 16 13 Alcohol response Blood ethanol concentration mean blood ethanol concentration at regain of righting reflex increased sensitivity to addictive substance Alcohol-Induced Disorders 1600610;1334439 16953387;15608595 1578696;1578700 LAS1;HAS1 intercross
1641908 rat Teswt1 Testicular weight QTL 1 7 3.28 33648 D7Mit5 33969 D7Mit4 Testicular weight DES-induced reduction of testis weight decreased testis weight Orchitis 1625009 16651691 3130 Myc 7 85089895 100273797 1 - by flanking markers 7 85110626 100308027 1 - by flanking markers 629500 LEXF intercross
1641910 rat Colcr3 Colorectal carcinoma resistance QTL 3 18 5.02 7.0E-6 38010 D18Rat46 38350 D18Rat38 38010 D18Rat46 Colorectal carcinoma resistance surface area of colorectal adenoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 2123 Apc 18 2571631 22807391 1 - by flanking markers 18 2571631 22834037 1 - by flanking markers 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641911 rat Alcrsp13 Alcohol response QTL 13 9 36157 D9Rat31 Alcohol response neurotensin receptor binding assay increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439;1600610 15608595;16953387 9 1 39963583 3 - by peak only 9 0 39960906 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641912 rat Alcrsp18 Alcohol response QTL 18 5 39186 D5Rat70 35651 D5Rat37 39402 D5Rat139 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance Alcohol-Induced Disorders 1600610;1334439 16953387;15608595 5 36386126 148460381 1 - by flanking markers 5 36386305 148470420 1 - by flanking markers 1641854 HAS.LAS-(D5Rat70-D5Rat37) intercross
1641913 rat Colcr2 Colorectal carcinoma resistance QTL 2 15 6.57 0.0197 38922 D15Rat38 37106 D15Rat31 37106 D15Rat31 Colorectal carcinoma resistance multiplicity of total colorectal lesions increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 15 2306220 25410881 1 - by flanking markers 15 2306221 25426581 1 - by flanking markers 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641915 rat Colcr9 Colorectal carcinoma resistance QTL 9 20 2.97 0.0024 35212 D20Rat13 33876 D20Mit4 35212 D20Rat13 Colorectal carcinoma resistance multiplicity of colorectal adenoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 20 1 32560683 4 - by one flank marker only 20 0 32574620 4 - by one flank marker only 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641917 rat Colcr5 Colorectal carcinoma resistance QTL 5 6 3.18 9.0E-4 34098 D6Mgh3 37076 D6Rat1 39052 D6Rat101 Colorectal carcinoma resistance multiplicity of colorectal adenoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 6 127683728 144152572 1 - by flanking markers 6 127687475 144158759 1 - by flanking markers 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641918 rat Alcrsp15 Alcohol response QTL 16 12 Alcohol response Blood ethanol concentration mean blood ethanol concentration at regain of righting reflex increased sensitivity to addictive substance Alcohol-Induced Disorders 1600610;1334439 16953387;15608595 1578696;1578700 LAS1;HAS1 intercross
1641919 rat Alc22 Alcohol consumption QTL 22 4 5.0E-4 37438 D4Rat119 34902 D4Rat55 Consumption level alcohol preference two bottle preference test; voluntary alcohol consumption increased alcohol consumption 1578304;1624272 16470346;17451403 2092;3197;3729;68368;735049;1307836;1308501;1310949;1311418 Akr1b1;Npy;Snca;Grid2;Dgki;Zfp212;Ppm1k;Sos1;Baiap1 additive 4 62832008 127941994 1 - by flanking markers 4 63108139 128186835 1 - by flanking markers 1641877 NP.P-(D4Rat119-D4Rat55)/Iusm
1641920 rat Colcs1 Colorectal carcinoma susceptibility QTL 1 5 2.99 0.0055 39406 D5Rat205 35823 D5Rat50 39250 D5Rat74 Colorectal carcinoma susceptibility surface area of colorectal adenoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641922 rat Alcrsp8 Alcohol response QTL 8 5 39186 D5Rat70 39402 D5Rat139 39186 D5Rat70 Alcohol response Blood ethanol concentration mean blood ethanol concentration at regain of righting reflex increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439;1600610 15608595;16953387 5 36386126 71377566 1 - by flanking markers 5 36386305 71382679 1 - by flanking markers 1578696;1578700 LAS1;HAS1 intercross
1641923 rat Colcr8 Colorectal carcinoma resistance QTL 8 18 3.1 0.0014 38350 D18Rat38 37738 D18Rat57 37738 D18Rat57 Colorectal carcinoma resistance multiplicity of poorly differentiated adenocarcinoma increased colonic adenoma incidence Colorectal Neoplasms 1625309 17510081 18 22807203 54605912 1 - by flanking markers 18 22833850 54674343 1 - by flanking markers 737892;1641864 ACI/SegHsd;WF/CrCrli intercross
1641925 rat Alcrsp2 Alcohol response QTL 2 2 35162 D2Rat38 38054 D2Rat138 35313 D2Rat53 Alcohol response loss of righting reflex loss of righting reflex test impaired righting response;increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439 15608595 2 155101972 230157845 1 - by flanking markers 2 155052021 230144585 1 - by flanking markers 1578696;1578700 LAS1;HAS1 intercross
1641926 rat Teswt2 Testicular weight QTL 2 1 2.82 33753 D1Mit5 10445 D1Wox25 Testicular weight DES-induced reduction of testis weight decreased testis weight Orchitis 1625009 16651691 1 202790380 247790380 4 - by one flank marker only 1 202950608 247950608 4 - by one flank marker only 629500 LEXF intercross
1641927 rat Alcrsp10 Alcohol response QTL 10 11 35323 D11Rat24 Alcohol response Blood ethanol concentration mean blood ethanol concentration increased sensitivity to addictive substance Alcohol-Induced Disorders 1334439 15608595 11 9165656 54165656 3 - by peak only 11 9204713 54204713 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641928 rat Alcrsp5 Alcohol response QTL 5 12 39332 D12Rat52 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance;impaired righting response Alcohol-Induced Disorders 1334439 15608595 12 13948769 46782294 3 - by peak only 12 13812157 46649226 3 - by peak only 1578696;1578700 LAS1;HAS1 intercross
1641833 rat Alc21 Alcohol consumption QTL 21 4 8.6 1.0E-4 34282 D4Mgh15 34902 D4Rat55 35409 D4Rat34 Consumption level alcohol preference two bottle preference test; voluntary alcohol consumption increased alcohol consumption 61483;1578304 9660316;16470346 3197 Npy additive 4 54879077 127941994 1 - by flanking markers 4 55129235 128186835 1 - by flanking markers 634380;634381 P;NP intercross
1642976 rat Bp301 Blood pressure QTL 301 10 blood pressure tail-cuff method increased systemic arterial blood pressure Hypertension 1642602 17893371 727916;1309875;1585229 Rffl;Lig3;LOC688779 1642968 SS.LEW-(D10Mco84-D10Rat58)/Mco intercross
1642980 rat Bp300 Blood pressure QTL 300 10 44761 D10Got88 66492 D10Mco62 blood pressure tail-cuff method decreased systemic arterial blood pressure Hypotension 1642602 17893371 3647;619957;620441;1303147;1303200;1566204;1596171 Ccl3;Expi;Ccl4;LOC360228;Ccl6;Heatr6;LOC689133 10 71662573 72063491 1 - by flanking markers 10 71676943 72077861 1 - by flanking markers 1642969 SS.LEW-(D10Mco84-D10Mco134)/Mco intercross
1643004 rat Pain2 Pain QTL 2 7 1.0 37382 D7Rat113 35264 D7Rat18 Pain surgery to induce neuropathic pain abnormal pain threshold Pain 1643003 17560719 7 10973606 103612887 1 - by flanking markers 7 10973607 103647117 1 - by flanking markers 1581623;1581640 LA/Humd;HA/Humd intercross
1643006 rat Pain1 Pain QTL 1 2 3.63 0.005 26.0 36145 D2Rat73 36659 D2Rat17 Pain surgery to induce neuropathic pain abnormal pain threshold Pain 1643003 17560719 2 26101088 48244982 1 - by flanking markers 2 26021458 48173215 1 - by flanking markers 1581623;1581640 LA/Humd;HA/Humd intercross
1642982 rat Bp302 Blood pressure QTL 302 10 blood pressure tail-cuff method decreased systemic arterial blood pressure Hypotension 1642602 17893371 71048;620757;1310708;1561538;1564411;1582982;1582997;1583007;1584095;1584109;1588811 Ap2b1;Pex12;Fndc8;Slfn14;Slfn4;LOC688925;LOC688910;Slfn1;LOC688871;LOC688857;LOC688477 1642972 SS.LEW-(D10Mco84-D10Mco143)/Mco intercross
1642290 rat Bp299 Blood pressure QTL 299 10 1642083 D10Mco88 1642081 D10Mco89 blood pressure tail-cuff method 1599269 17218081 69069;621743 Ccl5;Ddx52 1642272 SS.LEW-(D10Mco84-D10Got93)/Mco intercross
2293084 rat Iddm26 Insulin dependent diabetes mellitus QTL 26 2 2.9 36091 D2Rat44 36876 D2Rat88 42110 D2Arb16 Glucose level insulin-dependent presence of glycosuria and ketonuria Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2293011;2303106 1446803;19168599 1307992 Ptpn22 2 181710214 222281918 1 - by flanking markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn intercross
2293085 rat Iddm29 Insulin dependent diabetes mellitus QTL 29 6 7.06 34098 D6Mgh3 44208 D6Got167 37076 D6Rat1 Glucose level insulin-dependent presence of glycosuria and ketonuria Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2293011;2303106 1446803;19168599 6 127683728 146651354 1 - by flanking markers 2293012 ACI.BBDP-(RT1u),(Gimap5)/Sunn
2293086 rat Iddm30 Insulin dependent diabetes mellitus QTL 30 12 3.42 44938 D12Got11 36101 D12Rat15 37272 D12Rat28 Glucose level insulin-dependent presence of glycosuria and ketonuria Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2293011;2303106 1446803;19168599 3447 Ptpn11 12 8901318 29369703 1 - by flanking markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn intercross
2293087 rat Iddm27 Insulin dependent diabetes mellitus QTL 27 3 2.37 35799 D3Rat24 37980 D3Rat114 36882 D3Rat7 Glucose level insulin-dependent presence of glycosuria and ketonuria Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2293011;2303106 1446803;19168599 3 96506745 149496698 1 - by flanking markers 2293012 ACI.BBDP-(RT1u),(Gimap5)/Sunn intercross
2293088 rat Iddm28 Insulin dependent diabetes mellitus QTL 28 6 4.97 36729 D6Rat23 42786 D6Rat169 38494 D6Rat88 Glucose level insulin-dependent presence of glycosuria and ketonuria Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2293011;2303106 1446803;19168599 6 65393789 74436856 1 - by flanking markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn intercross
2290372 rat Gluco33 Glucose level QTL 33 7 2.71 38788 D7Rat72 41252 D7Rat149 35178 D7Rat47 Glucose level fasting oral glucose tolerance test (OGTT); blood glucose level was measured by a standard glucometer increased circulating glucose level Diabetes Mellitus, Experimental 1626640;2326163 17213368;20530722 7 13170547 32454105 1 - by flanking markers 7 13170548 32474376 1 - by flanking markers 1357181;1357191 CDR/Ygl;CDS/Ygl intercross
2290374 rat Gluco32 Glucose level QTL 32 4 11.35 39194 D4Rat115 35625 D4Rat14 41888 D4Rat282 Glucose level fasting oral glucose tolerance test (OGTT); blood glucose level was measured by a standard glucometer increased circulating glucose level;decreased circulating insulin level Diabetes Mellitus, Experimental 1626640;2326163 17213368;20530722 621465 Ica1 4 34206019 41729771 1 - by flanking markers 4 34324560 41849418 1 - by flanking markers 1357181;1357191 CDR/Ygl;CDS/Ygl intercross
2290375 rat Gluco34 Glucose level QTL 34 X 2.75 36111 DXRat8 33575 DXMit5 33575 DXMit5 Glucose level fasting increased circulating glucose level Diabetes Mellitus, Experimental 1626640;2326163 17213368;20530722 X 41386788 62894306 1 - by flanking markers X 41440348 62947775 1 - by flanking markers 1357181;1357191 CDR/Ygl;CDS/Ygl intercross
2293140 rat Bp313 Blood pressure QTL 313 1 66611 D1Mco36 2292719 D1Mco101 Blood pressure systolic systolic blood pressure measured by tail cuff method on conscious restrained rats decreased systemic arterial systolic blood pressure Hypotension 2291850 18324438 69305 Nr2f2 1 122991895 167991895 4 - by one flank marker only 2292653 SS.LEW-(D1Mco36-D1Mco101)/Mco intercross
2293142 rat Bp314 Blood pressure QTL 314 1 2292749 D1Mco85 35016 D1Rat106 Blood pressure systolic systolic blood pressure measured by tail cuff method on conscious restrained rats decreased systemic arterial systolic blood pressure Hypotension 2291850 18324438 1 94471673 139471673 4 - by one flank marker only 2292652 SS.LEW-(D1Mco85-D1Rat49)/Mco intercross
2303615 rat Vencon7 Ventilatory control QTL 7 5 0.001 38740 D5Rat113 Ventilatory control re-oxygenation after hypoxia ventilatory rate determined by whole body plethysmography 5 54207464 99207464 3 - by peak only 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303618 rat Vencon1 Ventilatory control QTL 1 5 3.8 40262 D5Rat157 Ventilatory control ventilatory rate determined by whole body plethysmography; metabolism with oxygen consumption 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303620 rat Vencon4 Ventilatory control QTL 4 3 3.1 36826 D3Rat12 36745 D3Rat1 36826 D3Rat12 Ventilatory control hypoxic challenge ventilatory rate determined by whole body plethysmography 3 127988419 170016653 1 - by flanking markers 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303622 rat Vencon6 Ventilatory control QTL 6 1 0.001 37870 D1Rat170 Ventilatory control re-oxygenation after hypoxia ventilatory rate determined by whole body plethysmography 1 158856292 203856292 3 - by peak only 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303623 rat Vencon2 Ventilatory control QTL 2 4 3.8 36926 D4Rat66 Ventilatory control re-oxygenation after hypoxia ventilatory rate determined by whole body plethysmography 4 138523557 183523557 3 - by peak only 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr
2303624 rat Vencon5 Ventilatory control QTL 5 6 4.45 35198 D6Rat11 Ventilatory control hypercapnic challenge ventilatory rate determined by whole body plethysmography 6 92737769 137737769 3 - by peak only 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303626 rat Vencon10 Ventilatory control QTL 10 20 0.001 38760 D20Rat39 Ventilatory control re-oxygenation after hypoxia ventilatory rate determined by whole body plethysmography 20 19840721 55268282 3 - by peak only 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303627 rat Vencon8 Ventilatory control QTL 8 17 0.001 34827 D17Rat12 Ventilatory control re-oxygenation after hypoxia ventilatory rate determined by whole body plethysmography 17 10777341 55777341 3 - by peak only 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303628 rat Vencon9 Ventilatory control QTL 9 19 0.005 35547 D19Rat25 Ventilatory control re-oxygenation after hypoxia ventilatory rate determined by whole body plethysmography 19 8121935 53121935 3 - by peak only 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2303629 rat Vencon3 Ventilatory control QTL 3 7 7.25 39016 D7Rat103 36099 D7Rat25 41106 D7Rat147 Ventilatory control re-oxygenation after hypoxia ventilatory rate determined by whole body plethysmography 7 44462790 60576660 1 - by flanking markers 2303610;2303611 SD/HsdCwr;BN/HsdMcwiCwr intercross
2306968 rat Anxrr23 Anxiety related response QTL 23 15 4.83 34910 D15Rat14 35611 D15Rat11 45269 D15Wox3 Anxiety response spontaneous activity measured in an elevated plus maze increased anxiety-related response 625384 11932246 additive 15 45870097 51526246 1 - by flanking markers 2306961;2306962 RLA/Verh;RHA/Verh intercross
2306970 rat Anxrr22 Anxiety related response QTL 22 10 5.95 34445 D10Mgh6 38844 D10Rat101 36019 D10Rat18 Anxiety response spontaneous activity measured in an elevated plus maze increased anxiety-related response 625384 11932246 additive 10 79621348 102796362 2 - by one flank and peak markers 2306961;2306962 RLA/Verh;RHA/Verh intercross
2306971 rat Anxrr21 Anxiety related response QTL 21 5 9.47 38768 D5Rat100 60485 D5Got42 43930 D5Wox4 Anxiety response avoidance response in the shuttle box impaired passive avoidance behavior;increased anxiety-related response;decreased grooming behavior 2313899;625384 18971309;11932246 additive 5 68843563 130756605 1 - by flanking markers 2306961;2306962 RLA/Verh;RHA/Verh intercross
2301962 rat Cm72 Cardiac mass QTL 72 13 4.12 10462 D13Mgh13 34567 D13Kid1 11232 D13Arb7 Cardiac mass left ventricle left ventricle mass was measured in mg heart left ventricle hypertrophy Hypertension 2301936 18925692 13 23769973 68769973 3 - by peak only 10016;631602 GH/Omr;BN/Elh intercross
2301964 rat Bp323 Blood pressure QTL 323 6 4.3 33993 D6Mit2 11241 D6Mit3 33828 D6Mit9 Blood pressure systolic tail-cuff method increased systemic arterial systolic blood pressure Hypertension 2301936 18925692 additive 6 75049644 84287190 1 - by flanking markers 10016;631602 GH/Omr;BN/Elh intercross
2301966 rat Bp322 Blood pressure QTL 322 2 3.58 34204 D2Mgh7 34461 D2Mgh12 34292 D2Mgh8 Blood pressure systolic tail-cuff method increased systemic arterial systolic blood pressure Hypertension 2301936 18925692 additive 2 156142685 210636169 1 - by flanking markers 10016;631602 GH/Omr;BN/Elh F2 intercross
2301967 rat Cm73 Cardiac mass QTL 73 10 4.55 33585 D10Mit6 33690 D10Mit7 10948 D10Mgh8 Cardiac mass left ventricle relative left ventricle mass(mg/g) was derived by dividing left ventricle mass in mg by body weight in g heart left ventricle hypertrophy Hypertension 2301936 18925692 10 14721135 92841289 2 - by one flank and peak markers 10016;631602 GH/Omr;BN/Elh intercross
2301969 rat Bp324 Blood pressure QTL 324 18 4.05 34290 D18Mgh4 34218 D18Mgh2 34270 D18Mgh6 Blood pressure systolic tail-cuff method increased systemic arterial systolic blood pressure Hypertension 2301936 18925692 18 62313112 78111426 2 - by one flank and peak markers 10016;631602 GH/Omr;BN/Elh intercross
2301970 rat Bw81 Body weight QTL 81 3 5.19 10678 D3Mgh21 34316 D3Mgh2 33808 D3Mit4 Body weight body weight was measured in grams increased body weight Obesity 2301936 18925692 3 39052756 158038027 1 - by flanking markers 10016;631602 GH/Omr;BN/Elh intercross
2301971 rat Cm71 Cardiac mass QTL 71 3 4.63 10678 D3Mgh21 34316 D3Mgh2 33808 D3Mit4 Cardiac mass left ventricle left ventricle mass was measured in mg heart left ventricle hypertrophy Hypertension 2301936 18925692 3 39052756 158038027 1 - by flanking markers 10016;631602 GH/Omr;BN/Elh intercross
2301972 rat Bp325 Blood pressure QTL 325 6 4.8 34643 D6Pas1 11241 D6Mit3 33828 D6Mit9 Blood pressure catheter placed in the carotid artery increased systemic arterial systolic blood pressure Hypertension 2301936 18925692 6 1 75049644 2 - by one flank and peak markers 10016;631602 GH/Omr;BN/Elh intercross
2306899 rat Bp338 Blood pressure QTL 338 4 0.071 36870 D4Rat33 35635 D4Rat54 Blood pressure salt-loaded systolic mean blood pressure, systolic, diastolic, and heart rate measured directly through a femoral artery catheter which was tunneled to the back of the rat decreased systemic arterial systolic blood pressure Hypotension 2306880 19126752 codominant 4 80205349 121829076 1 - by flanking markers 2306894 SHR.BN-(D4Rat33-D4Rat54)/Jk intercross
2306901 rat Bp337 Blood pressure QTL 337 2 0.01 40954 D2Rat226 36081 D2Rat294 Blood pressure salt-loaded systolic mean blood pressure, systolic, diastolic, and heart rate measured directly through a femoral artery catheter which was tunneled to the back of the rat decreased systemic arterial systolic blood pressure Hypotension 2306880 19126752 recessive 2 170338294 236153712 1 - by flanking markers 2306895 SHR.BN-(D2Rat226-D2Rat294)/Jk intercross
2306902 rat Bp339 Blood pressure QTL 339 16 0.01 40724 D16Rat87 34066 D16Mgh1 Blood pressure salt-loaded systolic mean blood pressure, systolic, diastolic, and heart rate measured directly through a femoral artery catheter which was tunneled to the back of the rat decreased systemic arterial systolic blood pressure Hypotension 2306880 19126752 recessive 16 3464719 46137590 1 - by flanking markers 2306893 SHR.BN-(D16Rat87-D16Mgh1)/Jk intercross
2306903 rat Bp336 Blood pressure QTL 336 2 0.01 37558 D2Rat114 37952 D2Rat123 Blood pressure salt-loaded systolic mean blood pressure, systolic, diastolic, and heart rate measured directly through a femoral artery catheter which was tunneled to the back of the rat decreased systemic arterial systolic blood pressure Hypotension 2306880 19126752 codominant 2 36432989 112326568 1 - by flanking markers 2306892 SHR.BN-(D2Rat114-D2Rat123)/Jk intercross
2312558 rat Glom17 Glomerulus QTL 17 1 3.9 0.001 37834 D1Rat164 39462 D1Rat289 39314 D1Rat216 Renal pathology glomerular injury score glomerular damage score determined by image analysis of collagen I deposition cortical renal glomerulopathies Glomerulosclerosis, Focal 2312422 18682577 1 170218208 201628746 2 - by one flank and peak markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2312560 rat Pur20 Proteinuria QTL 20 6 2.1 0.005 38282 D6Rat79 37076 D6Rat1 37076 D6Rat1 Renal function urine protein level urine specimens were assayed for proteinuria cortical renal glomerulopathies;increased protein excretion Glomerulosclerosis, Focal;Proteinuria 2312422 18682577 6 131029751 144152572 1 - by flanking markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2312562 rat Pur18 Proteinuria QTL 18 5 2.6 0.001 38744 D5Rat116 40256 D5Rat190 40250 D5Rat125 Renal function urine protein level urine specimens were analysed for total protein excretion by the biuret method cortical renal glomerulopathies;increased protein excretion Glomerulosclerosis, Focal;Proteinuria 2312422 18682577 5 1220773 24978263 1 - by flanking markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2312564 rat Glom18 Glomerulus QTL 18 1 2.4 0.003 41012 D1Rat287 36950 D1Rat77 37162 D1Rat72 Renal pathology percentage of glomeruli with microaneurysms was determined cortical renal glomerulopathies Glomerulosclerosis, Focal 2312422 18682577 1 190114247 238037551 1 - by flanking markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2312566 rat Glom20 Glomerulus QTL 20 11 3.6 0.001 36065 D11Rat6 10375 D11Mgh1 38558 D11Rat64 Renal pathology percentage of glomeruli with microaneurysms was determined cortical renal glomerulopathies Glomerulosclerosis, Focal 2312422 18682577 11 45232526 84560241 1 - by flanking markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2312567 rat Glom19 Glomerulus QTL 19 4 1.9 0.006 41458 D4Rat153 36143 D4Rat60 35325 D4Rat41 Renal pathology percentage of glomeruli with microaneurysms was determined cortical renal glomerulopathies Glomerulosclerosis, Focal 2312422 18682577 4 43686352 149560340 2 - by one flank and peak markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2312568 rat Glom21 Glomerulus QTL 21 18 2.0 0.005 35511 D18Rat31 37608 D18Rat53 35511 D18Rat31 Renal pathology percentage of glomeruli with microaneurysms was determined cortical renal glomerulopathies Glomerulosclerosis, Focal 2312422 18682577 18 5270273 42006239 1 - by flanking markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2312569 rat Pur19 Proteinuria QTL 19 4 3.4 0.001 41458 D4Rat153 35325 D4Rat41 36870 D4Rat33 Renal function urine protein level urine specimens were analysed for total protein excretion by the biuret method cortical renal glomerulopathies;increased protein excretion Glomerulosclerosis, Focal;Proteinuria 2312422 18682577 4 63787419 96623433 2 - by one flank and peak markers 737905;1331815 LEW/Maas;LEW/Mol backcross
2313046 rat Bss78 Bone structure and strength QTL 78 8 3.5 1.0E-4 33559 D8Mit5 34310 D8Mgh4 Bone strength cross-sectional moment of resistance (RP) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 8 32203394 86628010 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313048 rat Bss84 Bone structure and strength QTL 84 14 3.1 1.0E-4 33692 D14Mit12 60700 D14Mgh11 Bone strength cross-sectional moment of resistance (RP) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 14 40156028 85156028 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313049 rat Bss72 Bone structure and strength QTL 72 3 2.6 1.0E-4 37010 D3Rat49 11260 D3Mit8 Bone structure cortical cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 3 23762471 68762471 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313051 rat Bss57 Bone structure and strength QTL 57 1 3.7 1.0E-4 38782 D1Rat136 34134 D1Mgh1 Bone strength cross-sectional moment of inertia (IP) measurements performed by pQCT decreased bone strength;decreased bone mass Osteoporosis 2312767 19113924 1 37646940 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313053 rat Bss51 Bone structure and strength QTL 51 1 3.8 1.0E-4 37984 D1Rat232 36640 D1Rat14 Bone structure length of tibia was measured (in mm) using a calipers decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 17 1 2481129 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313055 rat Bw96 Body weight QTL 96 10 3.6 1.0E-4 33666 D10Mit16 33891 D10Mit5 Body weight weight of the body was recorded increased bone mineral density Osteoporosis 2312767 19113924 10 20018844 21607865 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313057 rat Bss76 Bone structure and strength QTL 76 8 3.0 1.0E-4 33559 D8Mit5 34310 D8Mgh4 Bone structure cortical periosteal (PC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 8 32203394 86628010 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313059 rat Bss55 Bone structure and strength QTL 55 1 3.2 1.0E-4 38782 D1Rat136 34134 D1Mgh1 Bone structure cortical periosteal (PC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 37646940 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
2313060 rat Bss71 Bone structure and strength QTL 71 1 2.6 1.0E-4 34134 D1Mgh1 11338 D1Wox20 Bone structure meta total cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength;decreased bone mineral density Osteoporosis 2312767 19113924 1 119780411 186391852 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313062 rat Bmd73 Bone mineral density QTL 73 1 3.9 1.0E-4 36568 D1Rat4 10442 D1Wox16 Bone mineral density cortical bone mineral content (BMC) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 1 11859997 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313064 rat Bmd71 Bone mineral density QTL 71 10 0.9 1.0E-4 33591 D10Mit14 33891 D10Mit5 Bone mineral density cortical bone mineral content (BMC) measurements performed by pQCT decreased bone mineral density Osteoporosis 2312767 19113924 10 5339759 21607865 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313065 rat Bss67 Bone structure and strength QTL 67 1 3.1 1.0E-4 36568 D1Rat4 10442 D1Wox16 Bone structure cortical cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 11859997 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313066 rat Bss63 Bone structure and strength QTL 63 10 1.4 1.0E-4 33591 D10Mit14 33891 D10Mit5 Bone strength cross-sectional moment of inertia (IP) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 10 5339759 21607865 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313067 rat Bss77 Bone structure and strength QTL 77 8 3.1 1.0E-4 33559 D8Mit5 34310 D8Mgh4 Bone structure endosteal circumferences (EC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 8 32203394 86628010 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313069 rat Bss68 Bone structure and strength QTL 68 1 2.9 1.0E-4 36568 D1Rat4 10442 D1Wox16 Bone structure cortical periosteal (PC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 11859997 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313070 rat Bss52 Bone structure and strength QTL 52 1 4.4 1.0E-4 37984 D1Rat232 36640 D1Rat14 Bone structure length of the body from the tip of the nose to tail base was measured (in cm) decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 17 1 2481129 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313072 rat Bss53 Bone structure and strength QTL 53 1 4.3 1.0E-4 38782 D1Rat136 34134 D1Mgh1 Bone structure length of tibia was measured (in mm) using a calipers decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 37646940 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313073 rat Bmd75 Bone mineral density QTL 75 2 4.1 1.0E-4 36173 D10Rat23 34401 D2Mgh22 Bone mineral density meta total volumetric BMD (vBMD) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 2 224179988 247306073 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313075 rat Bss66 Bone structure and strength QTL 66 1 3.4 1.0E-4 36568 D1Rat4 10442 D1Wox16 Bone structure length of tibia was measured (in mm) using a calipers decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 11859997 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313076 rat Bss74 Bone structure and strength QTL 74 3 2.0 1.0E-4 37010 D3Rat49 11260 D3Mit8 Bone strength cross-sectional moment of resistance (RP) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 3 23762471 68762471 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313077 rat Bss69 Bone structure and strength QTL 69 1 3.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 Bone strength cross-sectional moment of inertia (IP) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 11859997 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313078 rat Bss54 Bone structure and strength QTL 54 1 3.5 1.0E-4 38782 D1Rat136 34134 D1Mgh1 Bone structure cortical cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 37646940 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313079 rat Bss73 Bone structure and strength QTL 73 3 1.5 37010 D3Rat49 11260 D3Mit8 Bone structure cortical periosteal (PC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 3 23762471 68762471 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313080 rat Bss65 Bone structure and strength QTL 65 15 3.9 1.0E-4 42006 D15Arb2 34222 D15Mgh8 Bone structure meta total cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 15 67190176 80362100 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313081 rat Bss64 Bone structure and strength QTL 64 10 1.3 1.0E-4 33591 D10Mit14 33891 D10Mit5 Bone strength cross-sectional moment of resistance (RP) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 10 5339759 21607865 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313082 rat Bss85 Bone structure and strength QTL 85 18 0.8 1.0E-4 34059 D18Mit2 34236 D18Mgh5 Bone structure meta total cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 18 15584909 60584909 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313083 rat Bmd74 Bone mineral density QTL 74 1 4.0 1.0E-4 10442 D1Wox16 34134 D1Mgh1 Bone mineral density meta total volumetric BMD (vBMD) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 1 81947770 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313084 rat Bss83 Bone structure and strength QTL 83 14 2.9 1.0E-4 33692 D14Mit12 60700 D14Mgh11 Bone structure endosteal circumferences (EC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 14 40156028 85156028 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313085 rat Bss59 Bone structure and strength QTL 59 5 2.9 1.0E-4 39686 D5Rat119 60809 D5Wox7 Bone structure meta total cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 5 2965857 47965857 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313086 rat Bss60 Bone structure and strength QTL 60 8 4.1 1.0E-4 33973 D8Mit2 34310 D8Mgh4 Bone structure length of tibia was measured (in mm) using a calipers decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 8 53049279 86628010 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313087 rat Bmd80 Bone mineral density QTL 80 10 3.2 1.0E-4 33666 D10Mit16 33891 D10Mit5 Bone mineral density meta total volumetric BMD (vBMD) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 10 20018844 21607865 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313088 rat Bss75 Bone structure and strength QTL 75 8 3.1 1.0E-4 33559 D8Mit5 34310 D8Mgh4 Bone structure length of the body from the tip of the nose to tail base was measured (in cm) decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 8 32203394 86628010 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313089 rat Bss81 Bone structure and strength QTL 81 14 3.4 1.0E-4 33692 D14Mit12 60700 D14Mgh11 Bone structure length of the body from the tip of the nose to tail base was measured (in cm) decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 14 40156028 85156028 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2306850 rat Pia40 Pristane induced arthritis QTL 40 20 1.0E-4 41466 D20Rat45 40208 D20Rat47 Joint/bone inflammation pristane induced arthritis development monitored by a macroscopic scoring system increased resistance to induced joint inflammation;joint inflammation Arthritis, Rheumatoid 2306838 19180494 2306842 E3.DA-(D20Rat45-D20Rat47)/Rhd intercross
2292232 rat Pur16 Proteinuria QTL 16 13 17.2 45025 D13Got8 34833 D13Rat19 41978 D13Arb5 Renal function urine protein level urine protein level was measured by biuret method increased protein excretion Proteinuria 2292230 18064521 71024 Actr3 13 37191203 43437366 1 - by flanking markers 61118;61119 BUF/Mna;WKY/NCrlCrlj backcross
2313090 rat Bmd69 Bone mineral density QTL 69 1 4.4 1.0E-4 37984 D1Rat232 36640 D1Rat14 Bone mineral density cortical volumetric BMD (vBMD) measurements performed by pQCT decreased bone mineral density Osteoporosis 2312767 19113924 17 1 2481129 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313092 rat Bmd72 Bone mineral density QTL 72 1 2.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 Bone mineral density meta total volumetric BMD (vBMD) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 1 11859997 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313093 rat Bmd77 Bone mineral density QTL 77 3 2.2 1.0E-4 37010 D3Rat49 11260 D3Mit8 Bone mineral density cortical bone mineral content (BMC) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 3 23762471 68762471 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313094 rat Bss58 Bone structure and strength QTL 58 1 3.7 1.0E-4 38782 D1Rat136 34134 D1Mgh1 Bone strength cross-sectional moment of resistance (RP) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 37646940 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313095 rat Bss62 Bone structure and strength QTL 62 10 1.5 1.0E-4 33591 D10Mit14 33891 D10Mit5 Bone structure cortical periosteal (PC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 10 5339759 21607865 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
2313096 rat Bmd78 Bone mineral density QTL 78 5 3.1 1.0E-4 34136 D5Mgh21 34467 D5Mgh16 Bone mineral density meta total volumetric BMD (vBMD) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 5 151060403 168006088 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313097 rat Bss70 Bone structure and strength QTL 70 1 3.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 Bone strength cross-sectional moment of resistance (RP) measurements performed by pQCT decreased bone mass;decreased bone strength;decreased bone mineral density Osteoporosis 2312767 19113924 1 11859997 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313098 rat Bmd70 Bone mineral density QTL 70 1 3.6 1.0E-4 38782 D1Rat136 34134 D1Mgh1 Bone mineral density cortical bone mineral content (BMC) measurements performed by pQCT decreased bone mineral density Osteoporosis 2312767 19113924 1 37646940 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313099 rat Bss56 Bone structure and strength QTL 56 1 2.4 1.0E-4 38782 D1Rat136 34134 D1Mgh1 Bone structure endosteal circumferences (EC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 1 37646940 119780561 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313100 rat Bss82 Bone structure and strength QTL 82 14 3.0 1.0E-4 33692 D14Mit12 60700 D14Mgh11 Bone structure cortical periosteal (PC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 14 40156028 85156028 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313101 rat Bmd76 Bone mineral density QTL 76 3 3.6 1.0E-4 37010 D3Rat49 11260 D3Mit8 Bone mineral density meta total volumetric BMD (vBMD) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 3 23762471 68762471 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313102 rat Bmd79 Bone mineral density QTL 79 7 2.3 1.0E-4 33969 D7Mit4 33816 D7Mit11 Bone mineral density meta total volumetric BMD (vBMD) measurements performed by pQCT increased bone mineral density Osteoporosis 2312767 19113924 7 100273558 123635849 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313103 rat Bss80 Bone structure and strength QTL 80 10 2.0 1.0E-4 34110 D10Mgh13 35254 D10Rat2 Bone structure endosteal circumferences (EC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313104 rat Bss61 Bone structure and strength QTL 61 10 0.9 1.0E-4 33591 D10Mit14 33891 D10Mit5 Bone structure cortical cross-sectional area (CSA) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 10 5339759 21607865 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313105 rat Bss79 Bone structure and strength QTL 79 10 1.8 1.0E-4 34110 D10Mgh13 35254 D10Rat2 Bone structure cortical periosteal (PC) measurements performed by pQCT decreased bone mass;decreased bone strength Osteoporosis 2312767 19113924 10017;2302067 GK/KyoSwe;F344/DuCrlSwe intercross
2313854 rat Bp343 Blood pressure QTL 343 17 3.9 33882 D17Mit2 34120 D17Mgh5 2070 Agtr1a Blood pressure tail cuff plethysmography was done from 6-8 weeks; after the development of MH symptoms rats were killed, blood collected and angio-tensin-converting enzyme (ACE) activity determined weight loss;lethargy;abnormal pilomotor reflex;seizures;lethality-postnatal;abnormal induced morbidity/mortality;increased systemic arterial blood pressure Hypertension, Malignant;Polyuria;Hypertension;Seizures 619627 10432379 2070 Agtr1a 17 38353858 59104944 1 - by flanking markers 61109;629501;1298093 F344/NHsd;SD-Tg(Ren2)27;LEW/NHsd intercross
2313856 rat Bp342 Blood pressure QTL 342 10 4.4 1.0E-4 11308 D10Wox20 35256 D10Rat11 2493 Ace Blood pressure tail cuff plethysmography was done from 6-8 weeks; after the development of MH symptoms rats were killed, blood collected and angio-tensin-converting enzyme (ACE) activity determined weight loss;lethargy;abnormal pilomotor reflex;seizures;lethality-postnatal;abnormal induced morbidity/mortality;increased systemic arterial blood pressure Hypertension, Malignant;Polyuria;Seizures;Hypertension 2313695;619627 19307186;10432379 2493 Ace 10 91455572 100633982 1 - by flanking markers 61109;629501;1298093 F344/NHsd;SD-Tg(Ren2)27;LEW/NHsd intercross
2303118 rat Mamtr7 Mammary tumor resistance QTL 7 10 0.003 37526 D10Rat91 41584 D10Rat135 Mammary tumor resistance tumor growth rate mammary adenocarcinoma;decreased incidence of chemically-induced tumors Adenocarcinoma;Mammary Neoplasms, Experimental 2302423 19052818 10 9762188 108776963 1 - by flanking markers 2303116 SPRD.WKY-(D10Rat91-D10Rat135)/Ibmm intercross
2303120 rat Mamtr8 Mammary tumor resistance QTL 8 18 0.001 10690 D18Wox8 39278 D18Rat44 Mammary tumor resistance tumor growth rate mammary adenocarcinoma;decreased incidence of chemically-induced tumors Adenocarcinoma;Mammary Neoplasms, Experimental 2302423 19052818 18 41863411 86863411 4 - by one flank marker only 1599760 SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm intercross
2300002 rat Iddm36 Insulin dependent diabetes mellitus QTL 36 17 1.98 38698 D17Rat75 37402 D17Rat78 36185 D17Rat11 Glucose Level Insulin Dependent The animals became glycosuric (>5mmol/l), measured using Chemstrip test strips. Age to onset gave the highest LOD score Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2303106 19168599 17 22932286 47628829 1 - by flanking markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn
2292441 rat Bp308 Blood pressure QTL 308 10 1579031 D10Chm4 1578891 D10Chm29 Blood pressure arterial systolic and diastolic blood pressure was measured by telemetry and presented as mean arterial pressure decreased systemic arterial systolic blood pressure Hypotension 2292238 18398331 1592081 Mpo 2292390 SS.LEW-(D10Chm194-D10Chm243)/Ayd intercross
2292589 rat Emca10 Estrogen-induced mammary cancer QTL 10 6 0.048 37142 D6Rat80 41266 D6Rat146 Mammary tumor resistance mammary tumors detected by palpation absent spiral limbus Mammary Neoplasms, Experimental 2292503 18420736 6 1301952 46301952 4 - by one flank marker only 2292564 ACI.COP-(D6Rat80-D6Rat146)/Shul
2292591 rat Esta4 Estrogen-induced thymic atrophy QTL 4 3 39050 D3Rat130 37980 D3Rat114 Gland mass thymus thymus mass was determined thymus atrophy Thymoma 2292503 18420736 3 44551252 149496698 1 - by flanking markers 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul
2292613 rat Ept16 Estrogen-induced pituitary tumorigenesis QTL 16 3 8.3 35451 D3Rat21 39050 D3Rat130 35795 D3Rat26 Gland mass pituitary weight of the pituitary gland was determined pituitary gland hyperplasia Pituitary Neoplasms 2292503 18420736 3 44551542 110215186 1 - by flanking markers 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul intercross
2292615 rat Ept17 Estrogen-induced pituitary tumorigenesis QTL 17 3 6.7 11.0 41830 D3Rat277 34347 D3Mgh16 34186 D3Mgh9 Gland mass pituitary weight of the pituitary gland was determined pituitary gland hyperplasia Pituitary Neoplasms 2292503 18420736 3 6373454 22341164 1 - by flanking markers 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul intercross
2292616 rat Ept15 Estrogen-induced pituitary tumorigenesis QTL 15 6 4.4 1357998 D6Rat150 35683 D6Rat39 37142 D6Rat80 Gland mass pituitary weight of the pituitary gland was determined pituitary gland hyperplasia Pituitary Neoplasms 2292503 18420736 6 1 8184962 2 - by one flank and peak markers 2292564 ACI.COP-(D6Rat80-D6Rat146)/Shul intercross
2292617 rat Ept18 Estrogen-induced pituitary tumorigenesis QTL 18 10 3.9 7.0 35256 D10Rat11 36203 D10Rat27 33690 D10Mit7 Gland mass pituitary weight of the pituitary gland was determined pituitary gland hyperplasia Pituitary Neoplasms 2292503 18420736 10 77092169 100633512 1 - by flanking markers 2292567 ACI.COP-(D10Mgh8-D10Rat4)/Shul intercross
2312659 rat Slep7 Serum leptin concentration QTL 7 3 0.001 34228 D3Mgh5 36745 D3Rat1 Hormone level leptin serum leptin level measured by radio-immunoassay kit increased circulating leptin level Metabolic Syndrome X 2312642 19584880 61883;61965 Ghrh;Ptpn1 3 97523869 170016653 1 - by flanking markers 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K intercross
2312660 rat Bw95 Body weight QTL 95 16 0.05 39456 D16Rat88 45369 D16Wox7 Body weight adiposity index adiposity index determined as ratio between fat pads and body weight x 100 abnormal lateral ganglionic eminence morphology Metabolic Syndrome X 2312642 19584880 16 819225 63306215 1 - by flanking markers 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K intercross
2312662 rat Slep8 Serum leptin concentration QTL 8 10 0.05 34330 D10Mgh2 35665 D10Rat4 Hormone level leptin serum leptin level measured by radio-immunoassay kit increased circulating leptin level Metabolic Syndrome X 2312642 19584880 621087 Socs3 10 106422174 107033716 1 - by flanking markers 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K intercross
2312663 rat Slep9 Serum leptin concentration QTL 9 16 0.001 39456 D16Rat88 45369 D16Wox7 Hormone level leptin serum leptin level measured by radio-immunoassay kit increased circulating leptin level Metabolic Syndrome X 2312642 19584880 16 819225 63306215 1 - by flanking markers 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K intercross
2312664 rat Scl62 Serum cholesterol level QTL 62 3 0.05 33782 D3Mit10 37588 D3Rat189 Lipid level serum cholesterol serum cholesterol level determined by lipid electropheresis increased cholesterol level Metabolic Syndrome X;Hyperlipidemia 2312642 19584880 3 1 35797756 4 - by one flank marker only 2312644 DA.WOKW-(D3Mit10-D3Rat189)/K intercross
2312666 rat Insul16 Insulin level QTL 16 16 0.01 39456 D16Rat88 45369 D16Wox7 Insulin level serum serum insulin level measured by radio-immunoassay kit increased circulating insulin level Metabolic Syndrome X;Hyperinsulinemia 2312642 19584880 16 819225 63306215 1 - by flanking markers 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K intercross
2312668 rat Scl65 Serum cholesterol level QTL 65 10 0.001 34330 D10Mgh2 35665 D10Rat4 Lipid level serum cholesterol serum cholesterol level determined by lipid electropheresis increased cholesterol level Metabolic Syndrome X;Hyperlipidemia 2312642 19584880 10 106422174 107033716 1 - by flanking markers 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K intercross
2312669 rat Stl23 Serum triglyceride level QTL 23 16 0.01 39456 D16Rat88 45369 D16Wox7 Lipid level triglyceride serum triglyceride level determined by using an automatic analyser increased circulating triglyceride level Metabolic Syndrome X;Hyperlipidemia 2312642 19584880 16 819225 63306215 1 - by flanking markers 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K intercross
2312670 rat Bw94 Body weight QTL 94 3 0.01 34228 D3Mgh5 36745 D3Rat1 Body weight adiposity index adiposity index determined as ratio between fat pads and body weight x 100 abnormal lateral ganglionic eminence morphology Metabolic Syndrome X 2312642 19584880 61883;61965 Ghrh;Ptpn1 3 97523869 170016653 1 - by flanking markers 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K intercross
2312671 rat Scl64 Serum cholesterol level QTL 64 5 0.001 34216 D5Mgh6 34041 D5Mit5 Lipid level serum cholesterol serum cholesterol level determined by lipid electropheresis increased cholesterol level Metabolic Syndrome X;Hyperlipidemia 2312642 19584880 5 71814715 109163425 1 - by flanking markers 2312646 DA.WOKW-(D5Mgh6-D5Mit5)/K intercross
2312672 rat Insul15 Insulin level QTL 15 10 0.01 34330 D10Mgh2 35665 D10Rat4 Insulin level serum serum insulin level measured by radio-immunoassay kit increased circulating insulin level Metabolic Syndrome X;Hyperinsulinemia 2312642 19584880 621087 Socs3 10 106422174 107033716 1 - by flanking markers 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K intercross
2312673 rat Scl63 Serum cholesterol level QTL 63 3 0.001 34228 D3Mgh5 36745 D3Rat1 Lipid level serum cholesterol serum cholesterol level determined by lipid electropheresis increased cholesterol level Metabolic Syndrome X;Hyperlipidemia 2312642 19584880 61883;61965 Ghrh;Ptpn1 3 97523869 170016653 1 - by flanking markers 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K intercross
2307172 rat Activ4 Activity QTL 4 16 3.71 2.3E-4 39200 D16Rat32 Activity level motor activity in the open field test increased exploration in new environment;hyperactivity 2306974 19089625 16 1 33735317 3 - by peak only 61008;2292168 WAG;ISIAH intercross
2307174 rat Activ3 Activity QTL 3 2 4.83 5.8E-5 38280 D2Rat157 36876 D2Rat88 Activity level motor activity at the periphery in the open field test increased exploration in new environment;hyperactivity 2306974 19089625 2 216711618 222281918 1 - by flanking markers 61008;2292168 WAG;ISIAH intercross
2292222 rat Bp307 Blood pressure QTL 307 1 3.06 0.0014 35311 D1Rat54 35551 D1Rat117 38854 D1Rat168 blood pressure systolic blood pressure under stress in non-anaesthetized rats by tail-cuff method increased systemic arterial systolic blood pressure Hypertension 1626643 16700878 1 167931220 219629888 1 - by flanking markers 61008;2292168 WAG;ISIAH intercross
2293089 rat Iddm31 Insulin dependent diabetes mellitus QTL 31 14 4.08 36536 D14Rat1 33551 D14Mit6 36536 D14Rat1 Glucose level insulin-dependent presence of glycosuria and ketonuria Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2303106;2293011 19168599;1446803 14 4895894 19800418 1 - by flanking markers 2293012 ACI.BBDP-(RT1u),(Gimap5)/Sunn intercross
2314011 rat Gluco56 Glucose level QTL 56 1 35615 D1Rat70 39982 D1Rat323 36580 D1Rat112 Glucose level postprandial fasting rats were administered 2g/kg glucose and blood glucose concentrations measured at times 0, 60 and 120 min. increased circulating glucose level Hyperglycemia 2316693 20068026 additive 1 205040948 207483209 1 - by flanking markers 2314009 NMcwi:HS
2293083 rat Iddm25 Insulin dependent diabetes mellitus QTL 25 1 3.03 10951 D1Mit13 36960 D1Rat76 11060 D1Wox23 Glucose level insulin-dependent presence of glycosuria and ketonuria Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2293011;2303106 1446803;19168599 2870;2916 Igf2;Ins2 1 193831373 230411453 2 - by one flank and peak markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn
2292216 rat Bw80 Body weight QTL 80 1 3.23 0.0019 35551 D1Rat117 34971 D1Rat81 36960 D1Rat76 Body weight body weight was measured in grams decreased body weight Body Weight Changes 1626643 16700878 1 219629755 250119874 1 - by flanking markers 61008;2292168 WAG;ISIAH intercross
2292218 rat Kidm35 Kidney mass QTL 35 1 38854 D1Rat168 36960 D1Rat76 35551 D1Rat117 Kidney mass kidney weight was measured in grams; relative kidney weight is the ratio of kidney weight to body weight decreased kidney weight Body Weight Changes 1626643 16700878 1 204621918 230411453 1 - by flanking markers 61008;2292168 WAG;ISIAH intercross
2292220 rat Bp306 Blood pressure QTL 306 1 3.47 8.7E-4 35311 D1Rat54 34971 D1Rat81 38854 D1Rat168 blood pressure systolic basal blood pressure measured under short-term ether anaesthesia by tail-cuff method increased systemic arterial systolic blood pressure Hypertension 1626643 16700878 1 167931220 250119874 1 - by flanking markers 61008;2292168 WAG;ISIAH intercross
2289982 rat Bp303 Blood pressure QTL 303 10 36203 D10Rat27 35513 D10Rat24 blood pressure tail-cuff method decreased systemic arterial systolic blood pressure Hypotension 628510;1643425 11641286;18175179 10 77091834 79229233 1 - by flanking markers 10 77106262 79243603 1 - by flanking markers 1641871 SS.MNS-(D10Mco62-D10Mco31)/Jr intercross
2289983 rat Bp304 Blood pressure QTL 304 10 39500 D10Rat193 38286 D10Rat112 blood pressure tail-cuff method and telemetry decreased systemic arterial systolic blood pressure Hypotension 1643425 18175179 10 77219626 77679394 1 - by flanking markers 10 77233996 77693764 1 - by flanking markers 2289827 SS.MNS-(D10Mco30-D10Mco31)/Jr intercross
2289985 rat Bp305 Blood pressure QTL 305 10 1642087 D10Mco84 39500 D10Rat193 blood pressure tail-cuff method and telemetry decreased systemic arterial systolic blood pressure Hypotension 1643425 18175179 10 32219852 77219852 4 - by one flank marker only 10 32234222 77234222 4 - by one flank marker only 2289819 SS.MNS-(D10Mco62-D10Got99)/Mco intercross
2290005 rat Mcs24 Mammary carcinoma susceptibility QTL 24 5 69527 D5Uwm29 Mammary tumor susceptibility number of mammary tumors after 15 weeks of induction mammary adenocarcinoma Mammary Neoplasms, Experimental 1601189 17404222 1305229;1305465 Frmpd1;Fbxo10 61105;737908 WKY/NHsd;WF/NHsd
2290007 rat Mcs23 Mammary carcinoma susceptibility QTL 23 5 Mammary tumor susceptibility number of mammary tumors after 15 weeks of induction mammary adenocarcinoma Mammary Neoplasms, Experimental 1601189 17404222 1305465 Fbxo10 61105;737908 WKY/NHsd;WF/NHsd
2298495 rat Eae23 Experimental allergic encephalomyelitis QTL 23 10 16.93 1631253 D10Wox42 41254 D10Rat159 42370 D10Rat238 Brain/spinal cord inflammation severity determined by scoring animals for degree of tail and limb paralysis on a scale of 0-5 weight loss;CNS inflammation Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 2293859 16624898 70906;619913;631374;1308200;1309457 Aipl1;Tekt1;Slc13a5;Pitpnm3;Med31 additive 10 62204079 63167167 2 - by one flank and peak markers 2298494 Kini:DA,PVG-G10 intercross
2290393 rat Uae37 Urinary albumin excretion QTL 37 6 1.0E-4 38608 D6Rat106 36191 D6Rat6 36990 D6Rat12 Renal function urine albumin level measured by rat-specific ELISA proteinuria;albuminuria Albuminuria;Proteinuria 1642911 17953514 6 68036028 123455207 1 - by flanking markers 6 68039356 147642806 2 - by one flank and peak markers 1641831 MWF-Chr 6SHR/Rkb intercross
2290448 rat Scl54 Serum cholesterol level QTL 54 5 2.93 40330 D5Rat130 33680 D5Mit13 33985 D5Mit11 Lipid level cholesterol level plasma cholesterol, HDL-cholesterol, and total triglyceride levels were measured increased cholesterol level Hypercholesterolemia 2290428 17620956 5 32701659 138272129 1 - by flanking markers 5 32702146 138277355 1 - by flanking markers 1582184;2290429 SR/JrHsd;SS-Tg(ApoC3-CETP)53Opaz intercross
2290450 rat Scl57 Serum cholesterol level QTL 57 9 4.15 37604 D9Rat76 41600 D9Rat110 33999 D9Mit5 Lipid level cholesterol level plasma cholesterol, HDL-cholesterol, and total triglyceride levels were measured increased cholesterol level Hypercholesterolemia 2290428 17620956 9 33496794 94217673 1 - by flanking markers 9 33498209 94427153 1 - by flanking markers 1582184;2290429 SR/JrHsd;SS-Tg(ApoC3-CETP)53Opaz intercross
2290451 rat Scl58 Serum cholesterol level QTL 58 11 3.48 41734 D11Rat101 34150 D11Mgh5 34130 D11Mgh6 Lipid level cholesterol level plasma cholesterol, HDL-cholesterol, and total triglyceride levels were measured increased cholesterol level Hypercholesterolemia 2290428 17620956 11 12965570 43157054 1 - by flanking markers 11 12965570 43214643 1 - by flanking markers 1582184;2290429 SR/JrHsd;SS-Tg(ApoC3-CETP)53Opaz intercross
2290452 rat Scl56 Serum cholesterol level QTL 56 3 2.26 35795 D3Rat26 37510 D3Rat100 Lipid level cholesterol level plasma cholesterol, HDL-cholesterol, and total triglyceride levels were measured increased cholesterol level Hypercholesterolemia 2290428 17620956 3 1 90573782 2 - by one flank and peak markers 3 0 90470008 2 - by one flank and peak markers 1582184;2290429 SR/JrHsd;SS-Tg(ApoC3-CETP)53Opaz intercross
2290453 rat Scl55 Serum cholesterol level QTL 55 2 2.83 38976 D2Rat124 36466 D2Rat34 40292 D2Rat196 Lipid level cholesterol level plasma cholesterol, HDL-cholesterol, and total triglyceride levels were measured increased cholesterol level Hypercholesterolemia 2290428 17620956 2 96755420 141755420 4 - by one flank marker only 2 96705205 141705205 4 - by one flank marker only 1582184;2290429 SR/JrHsd;SS-Tg(ApoC3-CETP)53Opaz intercross;intercross
2301398 rat Kidm38 Kidney mass QTL 38 10 0.002 1578983 D10Chm156 2875 Igfbp4 Kidney mass kidney mass and aortic mass were taken decreased kidney weight;abnormal aortic weight Hypertension 1599557 17143582 10 42834315 87834315 4 - by one flank marker only 728384 SS.LEW-(D10Rat24-Igfbp4)/Ayd
2301400 rat Cm68 Cardiac mass QTL 68 3 0.001 728036 D3Chm60 39584 D3Rat206 Cardiac mass aorta Cardiac mass, aortic mass and kidney mass were taken decreased kidney weight;abnormal aortic weight;decreased heart weight Hypertension 1599557 17143582 3 27762470 72762470 4 - by one flank marker only 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd
2301402 rat Bp316 Blood pressure QTL 316 8 0.005 35018 D8Rat15 Blood pressure mean arterial mean arterial blood pressure was measured by implanting telemetry probes decreased kidney weight;abnormal aortic weight;decreased heart weight;decreased mean systemic arterial blood pressure;increased heart weight;increased mean systemic arterial blood pressure Hypertension 1302764;1599557 15257171;17143582 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd
2301404 rat Bp321 Blood pressure QTL 321 16 0.001 1358042 D16Chm66 39456 D16Rat88 Blood pressure mean arterial mean arterial blood pressure was measured by implanting telemetry probes decreased kidney weight;abnormal aortic weight;decreased heart weight;decreased mean systemic arterial blood pressure Hypotension 1599557 17143582 16 1 819369 4 - by one flank marker only 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd
2301405 rat Cm69 Cardiac mass QTL 69 10 0.031 1578987 D10Chm229 1578931 D10Chm171 Cardiac mass aorta Cardiac mass, aortic mass and kidney mass were taken decreased kidney weight;abnormal aortic weight;decreased heart weight Hypertension 1599557 17143582 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd
2301406 rat Kidm39 Kidney mass QTL 39 16 0.002 38834 D16Rat35 1358034 D16Chm63 Kidney mass kidney mass were taken decreased kidney weight Hypertension 1599557 17143582 16 16359278 61359278 4 - by one flank marker only 1358161 SS.LEW-(D16Rat38-D16Chm66)/Ayd
2301408 rat Kidm36 Kidney mass QTL 36 2 0.002 10153 D2Wox37 2044 Adh1 Kidney mass kidney mass were taken decreased kidney weight Hypertension 1599557 17143582 2 190811584 235811584 4 - by one flank marker only 1358167 SS.MNS-(D2Wox27-Adh1)/Ayd
2301409 rat Cm70 Cardiac mass QTL 70 18 0.001 38430 D18Rat62 1578949 D18Chm91 Cardiac mass aorta Cardiac mass, aortic mass and kidney mass were taken decreased kidney weight;abnormal aortic weight;decreased heart weight Hypertension 1599557 17143582 18 6934443 51934443 4 - by one flank marker only 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd
2301410 rat Bp317 Blood pressure QTL 317 18 11462 D18Wox7 40842 D18Rat101 Blood pressure mean arterial mean arterial blood pressure was measured by implanting telemetry probes increased mean systemic arterial blood pressure Hypertension 1578386;1599557 16278234;17143582 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd
2301411 rat Bp320 Blood pressure QTL 320 3 0.001 35378 D3Rat61 43758 D3Wox1 Blood pressure mean arterial mean arterial blood pressure was measured by implanting telemetry probes increased mean systemic arterial blood pressure Hypertension 1599557 17143582 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd
2301412 rat Kidm40 Kidney mass QTL 40 17 0.001 1556754 D17Chm14 45509 D17Wox7 Kidney mass kidney mass were taken decreased kidney weight Hypertension 1599557 17143582 17 44018862 89018862 4 - by one flank marker only 1559032;1559037 SS.LEW-(D17Rat65-D17Chm2)/Ayd;SS.LEW-(D17Chm9-D17Rat97)/Ayd
2301413 rat Bp318 Blood pressure QTL 318 18 40842 D18Rat101 1579069 D18Chm56 Blood pressure mean arterial mean arterial blood pressure was measured by implanting telemetry probes increased mean systemic arterial blood pressure Hypertension 1578386;1599557 16278234;17143582 18 27430874 72430874 4 - by one flank marker only 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd
2301414 rat Kidm37 Kidney mass QTL 37 3 0.001 39584 D3Rat206 36717 D3Rat17 Kidney mass kidney mass were taken decreased kidney weight Hypertension 1599557 17143582 3 76619110 121619110 4 - by one flank marker only 1357981 SS.LEW-(D3Mco21-D3Rat17)/Ayd
2301415 rat Cm67 Cardiac mass QTL 67 2 0.003 66535 D2Mco8 3195 Npr1 Cardiac mass aorta Cardiac mass, aortic mass and kidney mass were taken decreased kidney weight;abnormal aortic weight;decreased heart weight Hypertension 1599557 17143582 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd
2301416 rat Bp315 Blood pressure QTL 315 8 0.008 39028 D8Rat70 34723 D8Mgh9 Blood pressure mean arterial mean arterial blood pressure was measured by implanting telemetry probes increased mean systemic arterial blood pressure Hypertension 1302764;1599557 15257171;17143582 8 7408118 52408118 4 - by one flank marker only 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd
2301417 rat Bp319 Blood pressure QTL 319 18 37568 D18Rat55 62466 D18Uia6 Blood pressure mean arterial mean arterial blood pressure was measured by implanting telemetry probes increased mean systemic arterial blood pressure Hypertension 1578386;1599557 16278234;17143582 18 54856551 79195908 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd
2302038 rat Pia31 Pristane induced arthritis QTL 31 1 5.5 0.001 36550 D1Rat12 Joint/bone inflammation pristane induced total IgM level on day 14 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 additive 17 1 26143121 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302040 rat Pia35 Pristane induced arthritis QTL 35 1 3.8 0.001 10445 D1Wox25 Joint/bone inflammation pristane induced total IgG1 level on day 49 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 additive 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302042 rat Pia38 Pristane induced arthritis QTL 38 12 3.5 0.001 11449 D12Wox14 Joint/bone inflammation pristane induced total IgG1 level on day 49 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302043 rat Pia27 Pristane induced arthritis QTL 27 11 18.6 0.001 10376 D11Wox6 11044 D11Wox5 11044 D11Wox5 Joint/bone inflammation pristane induced IgM-RF levels on day 49 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 dominant 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302045 rat Pia39 Pristane induced arthritis QTL 39 14 4.9 0.001 38932 D14Rat36 Joint/bone inflammation pristane induced total IgG2a level on day 6 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 recessive 14 10539919 55539919 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302047 rat Pia34 Pristane induced arthritis QTL 34 19 5.8 0.001 33581 D19Mit1 Joint/bone inflammation pristane induced total IgG1 level on day 100 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 additive 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302049 rat Pia32 Pristane induced arthritis QTL 32 4 5.1 0.001 33933 D4Mit16 Joint/bone inflammation pristane induced total IgG level on day 100 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 recessive 4 107728559 152728559 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302051 rat Pia28 Pristane induced arthritis QTL 28 4 5.3 0.001 35325 D4Rat41 Joint/bone inflammation pristane induced IgG-RF levels on day 6 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 additive 4 74123346 119123346 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302053 rat Pia33 Pristane induced arthritis QTL 33 5 5.0 0.001 11072 D5Mgh2 Joint/bone inflammation pristane induced total IgG level on day 6 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 dominant 5 1 40017184 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302055 rat Pia30 Pristane induced arthritis QTL 30 3 3.5 0.001 11263 D3Wox14 Joint/bone inflammation pristane induced total IgM level on day 35 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302057 rat Pia29 Pristane induced arthritis QTL 29 16 3.6 0.001 34007 D16Mit3 Joint/bone inflammation pristane induced IgM-RF levels on day 14 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 recessive 16 24934312 69934312 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302059 rat Pia36 Pristane induced arthritis QTL 36 1 3.8 0.001 11144 D1Wox11 Joint/bone inflammation pristane induced total IgG1 level on day 100 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 1 41645883 86645883 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302060 rat Pia37 Pristane induced arthritis QTL 37 12 6.1 0.001 34070 D12Mgh7 Joint/bone inflammation pristane induced total IgG1 level on day 6 quantified by ELISA joint swelling;increased susceptibility to induced arthritis Arthritis, Rheumatoid 2302026 14674011 additive 12 14334630 46782294 3 - by peak only 634373;634374 DA/ZtmRhd;E3/ZtmRhd intercross
2302273 rat Gluco35 Glucose level QTL 35 3 5.3 0.001 42126 D3Arb18 33901 D3Mit12 33901 D3Mit12 Glucose level oral glucose tolerance test (OGTT) performed after 16 hours of fasting; blood glucose level measured by a portable glucose meter increased circulating glucose level Diabetes Mellitus 2298688 18612083 3 79283621 114574752 1 - by flanking markers 629497;1302627 SDT/CrljJcl;F344/NSlc intercross
2302275 rat Gluco37 Glucose level QTL 37 13 3.8 36922 D13Rat4 11375 D13Arb8 41978 D13Arb5 Glucose level oral glucose tolerance test (OGTT) performed after 16 hours of fasting; blood glucose level measured by a portable glucose meter increased circulating glucose level Diabetes Mellitus 2298688 18612083 13 1265159 76706487 2 - by one flank and peak markers 629497;1302627 SDT/CrljJcl;F344/NSlc intercross
2302276 rat Bw82 Body weight QTL 82 3 4.32 34336 D3Mgh7 42139 D3Arb8 11261 D3Wox9 Body weight body weight was measured in grams increased body weight Obesity 2298688 18612083 3 36556706 60697201 1 - by flanking markers 629497;1302627 SDT/CrljJcl;F344/NSlc intercross
2302277 rat Gluco38 Glucose level QTL 38 14 5.8 33953 D14Mit1 34890 D14Rat9 67231 D14Arb18 Glucose level oral glucose tolerance test (OGTT) performed after 16 hours of fasting; blood glucose level measured by a portable glucose meter increased circulating glucose level Diabetes Mellitus 2298688 18612083 14 12386493 30087990 1 - by flanking markers 629497;1302627 SDT/CrljJcl;F344/NSlc intercross
2302278 rat Gluco36 Glucose level QTL 36 8 4.2 40746 D8Rat162 33973 D8Mit2 36117 D8Rat46 Glucose level oral glucose tolerance test (OGTT) performed after 16 hours of fasting; blood glucose level measured by a portable glucose meter increased circulating glucose level Diabetes Mellitus 2298688 18612083 8 30878636 53049477 1 - by flanking markers intercross
2292436 rat Bp310 Blood pressure QTL 310 10 1579093 D10Chm14 36958 D10Rat9 Blood pressure arterial systolic and diastolic blood pressure was measured by telemetry and presented as mean arterial pressure decreased systemic arterial systolic blood pressure Hypotension 2292238 18398331 10 54588446 99588446 4 - by one flank marker only 1579903 SS.LEW-(D10Rat13-D10Rat11)/Ayd intercross
2292438 rat Bp311 Blood pressure QTL 311 10 44781 D10Got112 36958 D10Rat9 Blood pressure arterial systolic and diastolic blood pressure was measured by telemetry and presented as mean arterial pressure decreased systemic arterial systolic blood pressure Hypotension 2292238 18398331 10 79857808 99588446 1 - by flanking markers 2292386 SS.LEW-(D10Chm155-D10Chm127)/Ayd intercross
2292439 rat Bp309 Blood pressure QTL 309 10 1578850 D10Chm212 1579166 D10Chm3 Blood pressure arterial systolic and diastolic blood pressure was measured by telemetry and presented as mean arterial pressure decreased systemic arterial systolic blood pressure Hypotension 2292238 18398331 2364;620683;1308349 Cltc;Rps6kb1;Trim37 2292387 SS.LEW-(D10Chm224-D10Chm259)/Ayd intercross
2292440 rat Bp312 Blood pressure QTL 312 10 1578931 D10Chm171 1578994 D10Chm147 Blood pressure arterial systolic and diastolic blood pressure was measured by telemetry and presented as mean arterial pressure decreased systemic arterial systolic blood pressure Hypotension 2292238 18398331 2292388 SS.LEW-(D10Chm246-D10Chm257)/Ayd intercross
2293709 rat Bss23 Bone structure and strength QTL 23 6 5.18 1.0E-4 35653 D6Rat42 Bone structure total area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 6 1 42401411 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2305926 rat Iddm37 Insulin dependent diabetes mellitus QTL 37 20 6.0 40208 D20Rat47 Insulin level post-pancreatectomy 2313174 19720792 69418 Ubd additive 20 1616332 46616332 4 - by one flank marker only 2313181;2313209 LEW.1WR1/WorBrm;WF.ART2/Wor
2300218 rat Hpcl2 Hepatic cholesterol level QTL 2 10 34100 D10Mgh3 69423 Srebf1 Lipid level cholesterol Pliva-Lachema enzymatic assay for hepatic cholesterol measurements increased cholesterol level Fatty Liver 1643359 18071061 69423 Srebf1 10 46483646 100090301 1 - by flanking markers 2300217 SHR.BN-(D10Mgh3-Srebf1)/Ipcv intercross
2298475 rat Eau6 Experimental allergic uveoretinitis QTL 6 7 0.0029 10431 D7Wox18 Uvea inflammation uvea inflammation score abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation Uveitis 2296064 18453595 2454;2896;3735;71040;621312;628675 Cyp11b2;Il2rb;Sox10;Txn2;St13;Mapk15 7 90478161 135478161 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd intercross
2298477 rat Eau4 Experimental allergic uveoretinitis QTL 4 3 0.0011 10502 D3Mgh10 Uvea inflammation uvea inflammation score abnormal uvea morphology;increased susceptibility to experimental autoimmune uveoretinitis;eye inflammation Uveitis 2296064 18453595 2031;2200;2327;2810;2954;3267;61965;61998;68326;620228;620811;621320;628786;1303179 Ada;Bcl2l1;Cebpb;Hnf4a;Kcnb1;Pck1;Ptpn1;Ywhab;Vapb;Slco4a1;Slc12a5;Mmp9;Slc13a3;Bpi recessive 3 139485124 171063335 3 - by peak only 61109;1298093 F344/NHsd;LEW/NHsd intercross
2298478 rat Eau8 Experimental allergic uveoretinitis QTL 8 19 0.0163 10418 D19Mit6 Uvea inflammation uvea inflammation score abnormal uvea morphology;eye inflammation;decreased susceptibility to experimental autoimmune uveoretinitis Uveitis 2296064 18453595 2406;2444;2503;2825;2835;620573;620981;631410;1304832;1359653;1591020 Bcar1;Ctrb1;Nqo1;Hp;Hsd11b2;Cyba;Calb2;Vac14;Aars;Kars;Adat1 61109;1298093 F344/NHsd;LEW/NHsd intercross
2298479 rat Eau5 Experimental allergic uveoretinitis QTL 5 2 0.0021 34461 D2Mgh12 34401 D2Mgh22 67315 D2Arb24 Uvea inflammation uvea inflammation score abnormal uvea morphology;increased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;decreased susceptibility to experimental autoimmune uveoretinitis Uveitis 2296064 18453595 2263;2591;3810;69228;69238;70498;70967;620047;620241 Camk2d;Fabp2;Tacr3;Cxxc4;Prss12;Nfkb1;Casp6;Il2;Lef1 additive 2 210636008 247306073 1 - by flanking markers 61109;1298093 F344/NHsd;LEW/NHsd intercross
2298480 rat Eau7 Experimental allergic uveoretinitis QTL 7 10 0.0049 34318 D10Mgh10 61279 D10Arb3 33565 D10Mit9 Uvea inflammation uvea inflammation score abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;increased susceptibility to experimental autoimmune uveoretinitis;eye inflammation Uveitis 2296064 18453595 2425;2592;2897;2898;2900;2907;2920;3702;621149;628704;628847;1564790 Csf1r;Fabp6;Il3;Il4;Il5;Il9r;Irf1;Slc22a5;Slc22a4;Il12b;Mapk9;Scgb3a2 additive 10 35713561 36254741 1 - by flanking markers 61109;1298093 F344/NHsd;LEW/NHsd intercross
2298481 rat Eau9 Experimental allergic uveoretinitis QTL 9 10 0.0169 41939 D10Arb27 34274 D10Mgh5 41298 D10Rat153 Uvea inflammation uvea inflammation score abnormal uvea morphology;increased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;decreased susceptibility to experimental autoimmune uveoretinitis Uveitis 2296064 18453595 3185;3644;3645;3647;3830;69069;620441;629472 Nos2;Ccl11;Ccl2;Ccl3;Hnf1b;Ccl5;Ccl4;Cdk5r1 additive 10 69160380 86317054 1 - by flanking markers 61109;1298093 F344/NHsd;LEW/NHsd intercross
2300324 rat Fetw1 Fetal weight QTL 1 1 12.1 0.005 40.0 39312 D1Rat212 35569 D1Rat30 41498 D1Rat266 fetal weight on day 20 of pregnancy fetal weights were taken in 6 litters abnormal fetal growth/weight/body size Metabolic Syndrome X 2300320 16914718 1 55540384 100540384 4 - by one flank marker only 61098;61099 BXH;HXB
2300326 rat Plaw1 Placental weight QTL 1 15 15.0 0.005 43.0 36663 D15Rat21 41308 D15Rat107 40252 D15Rat101 Placental weight on day 20 of pregnancy placental weights were taken in 6 litters decreased placenta weight Metabolic Syndrome X 2300320 16914718 15 74779702 109758846 4 - by one flank marker only 61098;61099 BXH;HXB
2302365 rat Gluco40 Glucose level QTL 40 17 4.79 16.7 45514 D17Wox8 45485 D17Wox9 33707 D17Mit5 Glucose level blood glucose level measured after tail vein incision at 0, 10, 30, and 60 min after injection using glucose analyser increased circulating glucose level Metabolic Syndrome X 619689 10720472 17 65900518 93489534 1 - by flanking markers 737957;1357345 WOKW/K;DA/K intercross
2302367 rat Slep5 Serum leptin concentration QTL 5 8 3.43 33858 D8Mit4 33628 D8Mit6 Hormone level leptin serum leptin level measured by radio-immunoassay kit increased circulating leptin level Metabolic Syndrome X 619689 10720472 8 9581375 44484215 1 - by flanking markers 737957;1357345 WOKW/K;DA/K intercross
2302369 rat Scl60 Serum cholesterol level QTL 60 5 3.13 34210 D5Mgh14 34206 D5Mgh15 Lipid level serum cholesterol HDL-cholesterol and total cholesterol were analysed using an automatic analyser increased circulating cholesterol level Metabolic Syndrome X 619689 10720472 5 150236110 167844737 1 - by flanking markers 737957;1357345 WOKW/K;DA/K intercross
2302371 rat Stl22 Serum triglyceride level QTL 22 4 5.15 18.2 10800 D4Wox27 33757 D4Mit2 Lipid level triglyceride serum triglyceride level determined by using an automatic analyser increased circulating triglyceride level Metabolic Syndrome X 619689 10720472 4 10370202 55370202 4 - by one flank marker only 737957;1357345 WOKW/K;DA/K intercross
2302373 rat Gluco39 Glucose level QTL 39 3 5.01 24.2 34240 D3Mgh1 34228 D3Mgh5 33927 D3Mit3 Glucose level AUC (area under the curve) calculated from blood glucose measurements increased circulating glucose level Metabolic Syndrome X 619689 10720472 recessive 3 97524000 163778606 1 - by flanking markers 737957;1357345 WOKW/K;DA/K
2302375 rat Bw83 Body weight QTL 83 1 4.87 2.0E-4 30.7 33753 D1Mit5 10674 D1Mgh12 Body weight body weight was taken at age 22, 28, 30, and 32 wks increased body weight;increased body mass index Metabolic Syndrome X;Obesity 619689 10720472 1 202790380 247322277 1 - by flanking markers 737957;1357345 WOKW/K;DA/K intercross
2302377 rat Scl61 Serum cholesterol level QTL 61 17 4.36 12.5 33790 D17Mit3 45450 D17Wox3 33882 D17Mit2 Lipid level serum cholesterol HDL-cholesterol and total cholesterol were analysed using an automatic analyser increased circulating cholesterol level Metabolic Syndrome X 619689 10720472 17 33639527 62009961 1 - by flanking markers 737957;1357345 WOKW/K;DA/K intercross
2302378 rat Insul11 Insulin level QTL 11 1 3.25 33959 D1Mit3 10674 D1Mgh12 33753 D1Mit5 Insulin level serum insulin level measured by radio-immunoassay kit increased circulating insulin level Metabolic Syndrome X 619689 10720472 dominant 1 146971846 247322277 1 - by flanking markers 737957;1357345 WOKW/K;DA/K intercross
2302380 rat Slep6 Serum leptin concentration QTL 6 16 3.36 10660 D16Mgh3 Hormone level leptin serum leptin level measured by radio-immunoassay kit increased circulating leptin level Metabolic Syndrome X 619689 10720472 16 1 32464321 3 - by peak only 737957;1357345 WOKW/K;DA/K intercross
2302381 rat Bw84 Body weight QTL 84 5 4.47 15.9 34216 D5Mgh6 34041 D5Mit5 Body weight BMI Body mass index (BMI) was calculated by weighing the rats at 22, 28, 30, and 32 wks and body length measured at 32 wks increased body weight;increased body mass index Metabolic Syndrome X;Obesity 619689 10720472 5 71814715 109163425 1 - by flanking markers 737957;1357345 WOKW/K;DA/K intercross
2303559 rat Gluco54 Glucose level QTL 54 9 2.0 40738 D9Rat130 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 9 1 42602240 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303561 rat Bw91 Body weight QTL 91 17 2.0 36225 D17Rat15 Body weight body weight was measured at 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 17 15228042 60228042 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303563 rat Bw89 Body weight QTL 89 13 6.0 35997 D13Rat26 Body weight body weight was measured at 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 13 34327911 79327911 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303564 rat Gluco43 Glucose level QTL 43 8 3.0 36872 D8Rat43 Glucose level fasting glucose tolerance test was conducted and glucose oxidase method used to analyse glucose content increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 8 29077622 74077622 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303566 rat Bw90 Body weight QTL 90 16 2.0 42022 D16Arb5 Body weight body weight was measured at 11 and 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 16 1 40096603 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303568 rat Bw88 Body weight QTL 88 12 3.0 40394 D12Rat89 Body weight body weight was measured at 11 and 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 12 1 25457135 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303569 rat Gluco44 Glucose level QTL 44 12 2.0 39332 D12Rat52 Glucose level fasting glucose tolerance test was conducted and glucose oxidase method used to analyse glucose content decreased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 12 13948769 46782294 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303570 rat Gluco48 Glucose level QTL 48 8 2.0 36416 D8Rat31 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 8 53621297 98621297 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303571 rat Bw92 Body weight QTL 92 18 3.0 41878 D18Rat121 Body weight body weight was measured at 11 and 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 18 51949128 87265094 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303572 rat Insul13 Insulin level QTL 13 8 2.0 36872 D8Rat43 Insulin level determined by double antibody radioimmunoassay increased circulating insulin level Metabolic Syndrome X 2312611 19697080 additive 8 29077622 74077622 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303574 rat Gluco42 Glucose level QTL 42 5 2.0 36689 D5Rat14 Glucose level fasting glucose tolerance test was conducted and glucose oxidase method used to analyse glucose content increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 5 57040762 102040762 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303575 rat Insul14 Insulin level QTL 14 12 4.0 40702 D12Rat69 Insulin level determined by double antibody radioimmunoassay increased circulating insulin level Metabolic Syndrome X 2312611 19697080 additive 12 1 43562201 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303576 rat Gluco45 Glucose level QTL 45 1 4.0 39116 D1Rat145 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 1 225366432 267910886 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303577 rat Gluco47 Glucose level QTL 47 5 3.0 40386 D5Rat131 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 5 12890569 57890569 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303578 rat Gluco50 Glucose level QTL 50 20 2.0 37792 D20Rat29 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 20 25555772 55268282 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303579 rat Insul12 Insulin level QTL 12 1 4.0 39116 D1Rat145 Insulin level determined by double antibody radioimmunoassay increased circulating insulin level Metabolic Syndrome X 2312611 19697080 additive 1 225366432 267910886 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303580 rat Gluco49 Glucose level QTL 49 17 2.0 36526 D17Rat46 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured increased circulating glucose level Metabolic Syndrome X 2312611 19697080 619766 Cdc123 additive 17 61100283 97296363 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303581 rat Bw85 Body weight QTL 85 1 4.0 39116 D1Rat145 Body weight body weight was measured at 11 and 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 1 225366432 267910886 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303582 rat Gluco53 Glucose level QTL 53 7 3.0 36731 D7Rat24 Glucose level post-prandial gluco post-glucose content analysed by glucose oxidase method increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 61105;61109 WKY/NHsd;F344/NHsd intercross
2303584 rat Gluco55 Glucose level QTL 55 18 2.0 41878 D18Rat121 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 18 51949128 87265094 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303585 rat Bw86 Body weight QTL 86 4 4.0 39194 D4Rat115 Body weight body weight was measured at 11 and 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 4 11706134 56706134 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303586 rat Gluco52 Glucose level QTL 52 5 2.0 40262 D5Rat157 Glucose level post-prandial gluco post-glucose content analysed by glucose oxidase method decreased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 61105;61109 WKY/NHsd;F344/NHsd intercross
2303587 rat Bw93 Body weight QTL 93 20 13.0 37792 D20Rat29 Body weight body weight was measured and 17 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 20 25555772 55268282 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303589 rat Bw87 Body weight QTL 87 10 2.0 41042 D10Rat134 Body weight body weight was measured at 11 weeks of age increased body weight Metabolic Syndrome X 2312611 19697080 additive 10 86057484 110718848 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303591 rat Gluco41 Glucose level QTL 41 1 2.0 35057 D1Rat39 Glucose level fasting glucose tolerance test was conducted and glucose oxidase method used to analyse glucose content decreased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 1 103483490 148483490 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303592 rat Gluco51 Glucose level QTL 51 1 3.0 39116 D1Rat145 Glucose level post-prandial gluco post-glucose content analysed by glucose oxidase method increased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 1 225366432 267910886 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2303593 rat Gluco46 Glucose level QTL 46 3 3.0 41162 D3Rat181 Glucose level post-restraint animals kept in a restraint tube for 30 minutes then post-stress glucose level measured decreased circulating glucose level Metabolic Syndrome X 2312611 19697080 additive 3 25754538 70754538 3 - by peak only 61105;61109 WKY/NHsd;F344/NHsd intercross
2300197 rat Scl59 Serum cholesterol level QTL 59 14 38070 D14Rat43 43032 D14Rat132 Lipid level serum cholesterol total cholesterol level and liver cholesterol levels measured decreased circulating cholesterol level Hypercholesterolemia 2300117 18753676 1309450 Smek2 14 79256324 107101727 1 - by flanking markers 2300195 EHC.BN-(D14Rat43-D14Rat132)/Kyu
2312418 rat Kidm41 Kidney mass QTL 41 12 3.7 1.0E-4 11052 D12Wox11 41958 D12Arb14 Kidney mass kidney weight index determined decreased kidney weight Anti-Glomerular Basement Membrane Disease 2312387 19448344 recessive 12 665384 20932760 2 - by one flank and peak markers 61111;1358112 DA/Slc;WKY/NCrl
2312420 rat Pur17 Proteinuria QTL 17 1 7.1 1.0E-4 36105 D1Rat51 33945 D1Mit18 37732 D1Rat208 Renal function urine protein level urine specimens were assayed for proteinuria by a modified method using 2% sulfosalicyclic acid increased protein excretion Proteinuria;Anti-Glomerular Basement Membrane Disease 2312387 19448344 recessive 1 159782445 224426393 1 - by flanking markers 61111;1358112 DA/Slc;WKY/NCrl backcross
2306821 rat Bp335 Blood pressure QTL 335 7 0.001 1627404 D7Mco19 66604 D7Mco7 Blood pressure salt-loaded systolic systolic blood pressure measured by tail-cuff method decreased systemic arterial systolic blood pressure Hypotension 629613;2306800 12682779;19255363 2453;62037;1306132;1306316;1307850;1312017;1359378 Cyp11b1;Arc;Ly6d;Jrk;Gml;Lynx1;RGD1359378 7 67979667 112979667 4 - by one flank marker only 2306816 SS.SR-(D7Mco19-D7Mco7)/Jr intercross
2312598 rat Bp340 Blood pressure QTL 340 18 0.05 39518 D18Rat113 40782 D18Rat99 Blood pressure salt-loaded systolic and diastolic blood pressure measured by radiotelemetry increased systemic arterial blood pressure Hypertension 2312571 19620519 18 1 31654862 4 - by one flank marker only 2312580 SHR.BN-(D18Rat113-D18Rat82)/Ipcv intercross
2312600 rat Bp341 Blood pressure QTL 341 18 0.05 37412 D18Rat40 41356 D18Rat82 Blood pressure salt-loaded systolic and diastolic blood pressure measured by radiotelemetry increased systemic arterial blood pressure Hypertension 2312571 19620519 18 62106066 73666623 1 - by flanking markers 2312579 SHR.BN-(D18Rat40-D18Rat82)/Ipcv
2299160 rat Iddm35 Insulin dependent diabetes mellitus QTL 35 18 2.79 39582 D18Rat109 42052 D18Arb6 40002 D18Rat116 Glucose level insulin-dependent Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2303106 19168599 18 4320091 76880933 2 - by one flank and peak markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn
2299161 rat Iddm33 Insulin dependent diabetes mellitus QTL 33 2 2.98 35599 D2Rat82 34858 D2Rat69 36876 D2Rat88 Glucose level insulin-dependent Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2303106 19168599 1307992 Ptpn22 2 214633709 247295816 1 - by flanking markers 2293012 ACI.BBDP-(RT1u),(Gimap5)/Sunn
2299162 rat Iddm32 Insulin dependent diabetes mellitus QTL 32 2 2.36 36693 D2Rat75 35427 D2Rat8 39090 D2Rat180 Glucose level insulin-dependent Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2303106 19168599 620047;1307384;1359309 Il2;Il21;Adad1 2 30109071 79796790 1 - by flanking markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn
2299163 rat Iddm34 Insulin dependent diabetes mellitus QTL 34 7 2.71 36015 D7Rat21 35034 D7Rat2 1633865 D7Wox48 Glucose level insulin-dependent Insulin dependent diabetes Diabetes Mellitus, Insulin-Dependent 2303106 19168599 7 96517746 137757704 1 - by flanking markers 2293012;2306717 ACI.BBDP-(RT1u),(Gimap5)/Sunn;BBDP/WorSunn
2313395 rat Anxrr26 Anxiety related response QTL 26 19 36972 D19Rat21 35028 D19Rat2 36972 D19Rat21 Anxiety response domestication tameness/aggression measured by the glove test increased aggression toward humans;increased anxiety-related response 2313383 19363126 19 52161990 55455363 1 - by flanking markers 2313384 Wild/Nov intercross
2313397 rat Coatc1 Coat color QTL1 14 7.0 37624 D14Rat68 Coat color white spotting white spots were observed white spotting 2313383 19363126 additive 14 21150250 66150250 3 - by peak only 2313384 Wild/Nov intercross
2313399 rat Anxrr28 Anxiety related response QTL 28 6 42802 D6Rat229 10777 D6Wox11 42809 D6Rat184 Anxiety response domestication tameness/aggression measured by the glove test increased aggression toward humans;increased anxiety-related response 2313383 19363126 6 99749898 138261655 1 - by flanking markers 2313384 Wild/Nov intercross
2313400 rat Anxrr25 Anxiety related response QTL 25 8 2.3 41518 D8Rat135 38140 D8Rat72 35537 D8Rat12 Anxiety response domestication tameness/aggression measured by the glove test increased aggression toward humans;increased anxiety-related response 2313383 19363126 8 93585899 118725315 1 - by flanking markers 2313384 Wild/Nov intercross
2313401 rat Anxrr27 Anxiety related response QTL 27 4 11378 D4Wox30 10144 D4Mgh16 11378 D4Wox30 Anxiety response domestication tameness/aggression measured by the glove test increased aggression toward humans;increased anxiety-related response 2313383 19363126 4 16646915 61646915 4 - by one flank marker only 2313384 Wild/Nov intercross
2313402 rat Anxrr24 Anxiety related response QTL 24 1 5.1 38426 D1Rat191 33959 D1Mit3 10334 D1Wox14 Anxiety response domestication tameness/aggression measured by the glove test increased anxiety-related response;increased aggression toward humans 2313383 19363126 additive 1 43426139 146971983 1 - by flanking markers 2313384 Wild/Nov intercross
2306787 rat Ean3 Experimental allergic neuritis QTL 3 10 3.1 11480 D10Wox13 41468 D10Rat155 1637892 D0Got599 Peripheral nerve inflammation demyelination body weight taken and scored for clinical signs of experimental allergic neuritis weight loss;demyelination;muscle weakness Body Weight Changes;Guillain-Barre Syndrome;Neuritis, Experimental Allergic;Muscle Weakness 2306769 19299744 10 25229954 70229954 4 - by one flank marker only 2306784 Kini:DA,PVG-G12 intercross
2306789 rat Ean6 Experimental allergic neuritis QTL 6 12 4.9 11051 D12Mit2 36025 D12Rat23 44974 D12Got48 Peripheral nerve inflammation demyelination body weight taken and scored for clinical signs of experimental allergic neuritis demyelination;muscle weakness Guillain-Barre Syndrome;Neuritis, Experimental Allergic;Muscle Weakness 2306769 19299744 61307 Ncf1 12 20932559 25367251 1 - by flanking markers 2306784 Kini:DA,PVG-G12
2306790 rat Ean1 Experimental allergic neuritis QTL 1 20 0.05 Peripheral nerve inflammation demyelination weighed and scored for clinical signs of experimental allergic neuritis demyelination;muscle weakness Guillain-Barre Syndrome;Neuritis, Experimental Allergic;Muscle Weakness 2306736 15342198 737657 LEW.1AV1 intercross
2306792 rat Ean4 Experimental allergic neuritis QTL 4 10 4.0 39750 D10Rat190 66715 D10Mco15 40628 D10Rat142 Peripheral nerve inflammation demyelination body weight taken and scored for clinical signs of experimental allergic neuritis demyelination;muscle weakness;increased activated T cell number;increased T cell proliferation;abnormal interferon-gamma secretion Guillain-Barre Syndrome;Muscle Weakness;Neuritis, Experimental Allergic 2306769 19299744 co-recessive 10 87849516 98392508 1 - by flanking markers 2306784 Kini:DA,PVG-G12 intercross
2306793 rat Ean5 Experimental allergic neuritis QTL 5 10 4.7 66715 D10Mco15 39114 D10Rat87 39114 D10Rat87 Peripheral nerve inflammation demyelination body weight taken and scored for clinical signs of experimental allergic neuritis demyelination;muscle weakness;increased activated T cell number;increased T cell proliferation;abnormal interferon-gamma secretion Guillain-Barre Syndrome;Muscle Weakness;Neuritis, Experimental Allergic 2306769 19299744 10 76043832 98392296 1 - by flanking markers 2306784 Kini:DA,PVG-G12 intercross
2306794 rat Ean2 Experimental allergic neuritis QTL 2 4 6.4 38262 D4Rat103 36978 D4Rat38 40586 D4Rat231 Peripheral nerve inflammation demyelination body weight taken and scored for clinical signs of experimental allergic neuritis demyelination;muscle weakness;increased activated T cell number;increased T cell proliferation;abnormal interferon-gamma secretion Guillain-Barre Syndrome;Muscle Weakness;Neuritis, Experimental Allergic 2306769 19299744 4 82700691 96313512 1 - by flanking markers 2306784 Kini:DA,PVG-G12 intercross
2303168 rat Bp330 Blood pressure QTL 330 4 4.25 0.017 2901 Il6 34367 D4Mgh8 11015 D4Mit24 Blood pressure systolic and diastolic blood pressure measured by a catheter in the abdominal aorta via femoral artery decreased systemic arterial systolic blood pressure Hypotension 2303163 8829824 3197 Npy 4 456799 149181446 1 - by flanking markers 61119;1302620 WKY/NCrlCrlj;SHR/Kyo intercross
2303170 rat Bp332 Blood pressure QTL 332 9 3.73 0.027 11312 D9Bro1 33842 D9Mit6 10404 D9Mit2 Blood pressure systolic and diastolic blood pressure measured by a catheter in the abdominal aorta via femoral artery increased systemic arterial systolic blood pressure Hypertension 2303163 8829824 2421 Crygc 9 52598505 74813207 2 - by one flank and peak markers 61119;1302620 WKY/NCrlCrlj;SHR/Kyo intercross
2303171 rat Bp331 Blood pressure QTL 331 8 5.57 0.005 34415 D8Mgh6 10054 D8Wox10 10054 D8Wox10 Blood pressure systolic systolic and diastolic blood pressure measured by a catheter in the abdominal aorta via femoral artery decreased systemic arterial systolic blood pressure Hypotension 2303163 8829824 3346 Plcd1 8 64762472 124310219 1 - by flanking markers 61119;1302620 WKY/NCrlCrlj;SHR/Kyo intercross
2303028 rat Bp329 Blood pressure QTL 329 13 42997 D13Rat179 45069 D13Got53 Blood pressure salt-loaded mean arterial microrenathane catheter placed in the left femoral artery decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 3654;67366;619761;620349 Sele;Pla2g4a;Fmo3;Ptgs2 13 60669451 76779489 1 - by flanking markers 2302984 SS.BN-(D13Rat151-D13Rat197)/Mcwi intercross
2303030 rat Bp327 Blood pressure QTL 327 13 39804 D13Rat111 39208 D13Rat88 Blood pressure salt-loaded mean arterial microrenathane catheter placed in the left femoral artery decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 2446;620465 Ctse;Cxcr4 13 32030139 42627837 1 - by flanking markers 2302985 SS.BN-(D13Rat111-D13Got22)/Mcwi intercross
2303031 rat Bp326 Blood pressure QTL 326 13 35975 D13Rat7 39032 D13Rat60 Blood pressure salt-loaded mean arterial microrenathane catheter placed in the left femoral artery decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 13 1084268 13053933 1 - by flanking markers 2302987 SS.BN-(D13Rat7-D13Rat60)/Mcwi intercross
2303032 rat Bp328 Blood pressure QTL 328 13 39208 D13Rat88 38240 D13Rat91 Blood pressure salt-loaded mean arterial microrenathane catheter placed in the left femoral artery decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 2048;3554;621137;1303151 Adora1;Ren;Rnpep;Adipor1 13 42627610 46912163 1 - by flanking markers 2302986 SS.BN-(D13Rat88-D13Rat91)/Mcwi intercross
2300157 rat Bmd66 Bone mineral density QTL 66 18 13.1 1.0E-4 38146 D18Rat50 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 18 31347803 76347803 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300159 rat Bmd61 Bone mineral density QTL 61 14 5.3 1.0E-4 39204 D14Rat54 Bone mineral density distal femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 14 1 27616586 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300161 rat Bmd43 Bone mineral density QTL 43 1 8.4 1.0E-4 36460 D1Rat69 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300163 rat Bmd64 Bone mineral density QTL 64 16 5.3 1.0E-4 40234 D16Rat60 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 16 41581459 86581459 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300164 rat Bmd44 Bone mineral density QTL 44 1 5.4 1.0E-4 39532 D1Rat261 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 1 56601368 101601368 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300165 rat Bmd49 Bone mineral density QTL 49 2 4.8 1.0E-4 40462 D2Rat280 Bone mineral density vertebral areal BMD (aBMD) measurements performed by DXA abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300167 rat Bmd63 Bone mineral density QTL 63 15 5.9 1.0E-4 40084 D15Rat117 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 15 16042557 61042557 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300168 rat Bmd47 Bone mineral density QTL 47 2 6.6 1.0E-4 39874 D2Rat198 Bone mineral density whole femur areal BMD (aBMD) measurements performed by DXA abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 2 20374107 65374107 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300170 rat Bmd45 Bone mineral density QTL 45 2 12.1 1.0E-4 40462 D2Rat280 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300171 rat Bmd58 Bone mineral density QTL 58 10 4.9 1.0E-4 40302 D10Rat162 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 10 28599269 73599269 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300172 rat Bmd57 Bone mineral density QTL 57 10 9.8 1.0E-4 36283 D10Rat15 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 10 74167134 110718848 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300173 rat Bmd62 Bone mineral density QTL 62 15 12.8 1.0E-4 40084 D15Rat117 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105;2316850 18707222;19153792;19841953 1308288;1311147;1312015;1359146;1592114 Lcp1;Mdp1;Xpo4;Pdhb;Esd 15 16042557 61042557 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300174 rat Bmd42 Bone mineral density QTL 42 1 8.4 1.0E-4 36460 D1Rat69 Bone mineral density vertebral areal BMD (aBMD) measurements performed by DXA abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300175 rat Bmd40 Bone mineral density QTL 40 1 15.4 1.0E-4 37902 D1Rat169 Bone mineral density whole femur areal BMD (aBMD) measurements performed by DXA abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 1 207376933 252376933 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300176 rat Bmd51 Bone mineral density QTL 51 6 11.7 1.0E-4 35963 D6Rat46 Bone mineral density whole femur areal BMD (aBMD) measurements performed by DXA abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 6 1 35786687 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300177 rat Bmd65 Bone mineral density QTL 65 18 19.7 1.0E-4 38146 D18Rat50 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 18 31347803 76347803 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300178 rat Bmd54 Bone mineral density QTL 54 7 5.3 1.0E-4 35919 D7Rat23 Bone mineral density distal femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 7 52159077 97159077 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300179 rat Bmd50 Bone mineral density QTL 50 4 5.9 1.0E-4 38262 D4Rat103 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 4 60200806 105200806 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300180 rat Bmd67 Bone mineral density QTL 67 18 4.8 1.0E-4 37578 D18Rat65 Bone mineral density whole femur areal BMD (aBMD) measurements performed by DXA abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 18 1 34745192 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300181 rat Bmd55 Bone mineral density QTL 55 8 5.7 1.0E-4 35018 D8Rat15 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 8 81048802 126048802 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300182 rat Bmd56 Bone mineral density QTL 56 8 5.4 36327 D8Rat2 Bone mineral density distal femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 8 100915338 129041809 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300183 rat Bmd60 Bone mineral density QTL 60 14 5.7 1.0E-4 39204 D14Rat54 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 14 1 27616586 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300184 rat Bmd53 Bone mineral density QTL 53 7 5.4 1.0E-4 37802 D7Rat78 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 7 98036672 143002779 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300185 rat Bmd46 Bone mineral density QTL 46 2 8.4 1.0E-4 40462 D2Rat280 Bone mineral density distal femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300186 rat Bmd59 Bone mineral density QTL 59 12 7.1 1.0E-4 39060 D12Rat30 Bone mineral density vertebral volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 12 11612769 46782294 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300187 rat Bmd41 Bone mineral density QTL 41 1 8.9 1.0E-4 36460 D1Rat69 Bone mineral density distal femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300188 rat Bmd68 Bone mineral density QTL 68 20 6.4 1.0E-4 37792 D20Rat29 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109;2303105 18707222;19153792 20 25555772 55268282 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300189 rat Bmd48 Bone mineral density QTL 48 2 5.8 1.0E-4 36031 D2Rat54 Bone mineral density mid-femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 2 187512114 232512114 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2300190 rat Bmd52 Bone mineral density QTL 52 6 11.2 1.0E-4 35963 D6Rat46 Bone mineral density distal femur volumetric BMD (vBMD) measurements performed by pQCT abnormal epididymis epithelium morphology Osteoporosis 2300109 18707222 6 1 35786687 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2298542 rat Neuinf11 Neuroinflammation QTL 11 3 0.6 36657 D3Rat58 35443 D3Rat30 10260 D3Rat52 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 3 10829503 75308165 1 - by flanking markers 737945;2312352 BN/Han;LEW.1N
2298544 rat Neuinf9 Neuroinflammation QTL 9 10 4.6 44672 D10Got12 37450 D10Rat133 36496 D10Rat37 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 10 5761138 65668639 1 - by flanking markers 737945;2312352 BN/Han;LEW.1N
2298545 rat Neuinf8 Neuroinflammation QTL 8 1 2.9 37960 D1Rat196 35667 D1Rat107 35268 D1Rat34 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 1 55083934 154002647 1 - by flanking markers 737945;2312352 BN/Han;LEW.1N
2298546 rat Neuinf4 Neuroinflammation QTL 4 1 3.5 38230 D1Rat234 37658 D1Rat247 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 1 1 41225199 2 - by one flank and peak markers 737945;2312352 BN/Han;LEW.1N
2298547 rat Neuinf5 Neuroinflammation QTL 5 7 2.7 37382 D7Rat113 39094 D7Rat58 41516 D7Rat148 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 7 10973606 87034412 2 - by one flank and peak markers 737945;2312352 BN/Han;LEW.1N
2298548 rat Neuinf7 Neuroinflammation QTL 7 10 2.2 37450 D10Rat133 35627 D10Rat12 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 10 65668446 110718848 2 - by one flank and peak markers 737945;2312352 BN/Han;LEW.1N
2298549 rat Neuinf12 Neuroinflammation QTL 12 15 2.2 37794 D15Rat48 38578 D15Rat73 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 15 1 61161186 2 - by one flank and peak markers 737945;2312352 BN/Han;LEW.1N
2298550 rat Neuinf6 Neuroinflammation QTL 6 7 3.3 36715 D7Rat30 37382 D7Rat113 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 7 1 30339432 2 - by one flank and peak markers 737945;2312352 BN/Han;LEW.1N
2298551 rat Neuinf10 Neuroinflammation QTL 10 11 3.7 35933 D11Rat12 37942 D11Rat46 41240 D11Rat83 Neuroinflammation abnormal level of surface class II molecules Autoimmune Diseases of the Nervous System 2311085 19525015 additive 11 31988113 81091531 1 - by flanking markers 737945;2312352 BN/Han;LEW.1N
2303178 rat Bp334 Blood pressure QTL 334 9 0.01 61287 D9Uia6 2302873 D9Mco93 Blood pressure salt-loaded systolic systolic blood pressure measured by tail-cuff method decreased systemic arterial systolic blood pressure Hypotension 2302803 18854752 9 77170797 113440463 4 - by one flank marker only 2303153 SS.SHR-(D9Uia6-D9Mco93)/Mco intercross
2303180 rat Bp333 Blood pressure QTL 333 9 3.7 0.001 2302913 D9Mco76 2302927 D9Mco85 44654 D9Got111 Blood pressure salt-loaded systolic systolic blood pressure measured by tail-cuff method proteinuria;decreased systemic arterial systolic blood pressure Hypotension;Proteinuria 2302803 18854752 9 66749809 111749809 3 - by peak only 2303154 SS.SHR-(D9Wox16-D9Mco85)/Mco intercross
2293341 rat Glom15 Glomerulus QTL 15 13 7.4 36506 D13Rat32 34945 D13Rat51 39262 D13Rat86 Renal pathology glomerulus inflammation invitro assay to determine glomerular pathology of antibody-coated glomerular mesangial cells by macrophage-mediated killing glomerulonephritis Glomerulonephritis;Nephritis 2293335;2325762 16482158;20488952 71069 Fcgr2a 13 78189125 106076220 1 - by flanking markers 1298093;1358112 LEW/NHsd;WKY/NCrl intercross
2293343 rat Glom16 Glomerulus QTL 16 16 9.1 39456 D16Rat88 34894 D16Rat29 41618 D16Rat82 Renal pathology glomerulus inflammation invitro assay to determine glomerular pathology of antibody-coated glomerular mesangial cells by macrophage-mediated killing glomerulonephritis Glomerulonephritis;Nephritis 2293335;2293336;2325762 16482158;18443593;20488952 2945 Jund 16 819225 49333382 1 - by flanking markers 1298093;1358112 LEW/NHsd;WKY/NCrl intercross
2293642 rat Bss37 Bone structure and strength QTL 37 5 4.64 1.0E-4 35545 D5Rat28 39478 D5Rat204 42185 D5Arb1 Bone strength ultimate force of the femur was calculated from the force versus displacement curve abnormal bone structure Osteoporosis 2293455 18158281 5 126963761 157597184 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293644 rat Bmd29 Bone mineral density QTL 29 7 5.4 1.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 Bone mineral density total area measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 7 74658964 120536775 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293646 rat Bss25 Bone structure and strength QTL 25 10 10.96 1.0E-4 36283 D10Rat15 Bone structure total area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 10 74167134 110718848 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293648 rat Bmd31 Bone mineral density QTL 31 17 4.5 1.0E-4 38150 D17Rat80 34827 D17Rat12 34827 D17Rat12 Bone mineral density cortical area measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 17 10044240 33277509 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293650 rat Bss31 Bone structure and strength QTL 31 6 5.05 1.0E-4 35653 D6Rat42 Bone structure polar moment of inertia (Ip) measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 6 1 42401411 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293652 rat Bmd22 Bone mineral density QTL 22 10 4.9 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 Bone mineral density total vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 10 51099067 85484602 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293654 rat Bss30 Bone structure and strength QTL 30 1 32.65 1.0E-4 36460 D1Rat69 Bone structure polar moment of inertia (Ip) measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293655 rat Bss36 Bone structure and strength QTL 36 1 10.66 1.0E-4 37902 D1Rat169 Bone strength ultimate force of the femur was calculated from the force versus displacement curve abnormal bone structure Osteoporosis 2293455 18158281 1 207376933 252376933 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293656 rat Bss28 Bone structure and strength QTL 28 6 6.79 1.0E-4 35653 D6Rat42 Bone structure cortical area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 6 1 42401411 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293658 rat Bmd23 Bone mineral density QTL 23 18 7.3 1.0E-4 38146 D18Rat50 34975 D18Rat13 34975 D18Rat13 Bone mineral density total vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 18 53847683 87265094 4 - by one flank marker only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293659 rat Bmd35 Bone mineral density QTL 35 4 4.5 1.0E-4 37850 D4Rat104 36562 D4Rat72 36562 D4Rat72 Bone mineral density ultimate force measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 4 140454608 186104310 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293661 rat Bss50 Bone structure and strength QTL 50 18 4.64 3.0E-4 37578 D18Rat65 Bone structure trabecular area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 18 1 34745192 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293663 rat Bss33 Bone structure and strength QTL 33 10 9.34 1.0E-4 36283 D10Rat15 Bone structure polar moment of inertia (Ip) measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 10 74167134 110718848 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293664 rat Bmd28 Bone mineral density QTL 28 17 4.7 1.0E-4 38150 D17Rat80 34827 D17Rat12 34827 D17Rat12 Bone mineral density trabecular vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 17 10044240 33277509 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293666 rat Bmd38 Bone mineral density QTL 38 5 4.4 40562 D5Rat187 35132 D5Rat3 Bone mineral density cortical area measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 5 8464827 40137122 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293667 rat Bss42 Bone structure and strength QTL 42 7 7.25 1.0E-4 35919 D7Rat23 Bone structure total area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 7 52159077 97159077 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293669 rat Bmd33 Bone mineral density QTL 33 10 4.5 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 Bone mineral density polar moment of inertia measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 10 51099067 85484602 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293671 rat Bss44 Bone structure and strength QTL 44 2 10.97 1.0E-4 39874 D2Rat198 37330 D2Rat181 40462 D2Rat280 Bone structure cortical area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 2 42874025 153832507 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293673 rat Bss27 Bone structure and strength QTL 27 1 18.63 1.0E-4 36460 D1Rat69 Bone structure cortical area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293674 rat Bss39 Bone structure and strength QTL 39 1 7.1 1.0E-4 37902 D1Rat169 Bone strength work to failure of the femur was calculated from the force versus displacement curve abnormal bone structure Osteoporosis 2293455 18158281 1 207376933 252376933 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293676 rat Bmd19 Bone mineral density QTL 19 2 10.7 1.0E-4 39874 D2Rat198 40462 D2Rat280 40462 D2Rat280 Bone mineral density total vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 2 42874025 87874025 4 - by one flank marker only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293677 rat Bss41 Bone structure and strength QTL 41 1 9.38 1.0E-4 36460 D1Rat69 Bone structure total area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293678 rat Bss24 Bone structure and strength QTL 24 7 6.71 1.0E-4 35919 D7Rat23 Bone structure total area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 7 52159077 97159077 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293679 rat Bmd30 Bone mineral density QTL 30 10 3.5 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 Bone mineral density total area measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 10 51099067 85484602 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293680 rat Bss40 Bone structure and strength QTL 40 10 5.66 1.0E-4 33630 D10Mit17 Bone strength work to failure or the femur was calculated from the force versus displacement curve abnormal bone structure Osteoporosis 2293455 18158281 10 1 35460104 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293682 rat Bmd24 Bone mineral density QTL 24 2 8.9 1.0E-4 39874 D2Rat198 40462 D2Rat280 40462 D2Rat280 Bone mineral density cortical vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 2 42874025 87874025 4 - by one flank marker only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293684 rat Bmd26 Bone mineral density QTL 26 12 4.4 2.0E-4 40408 D12Rat91 39060 D12Rat30 40408 D12Rat91 Bone mineral density cortical vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 12 16387455 34112949 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293685 rat Bmd21 Bone mineral density QTL 21 7 4.2 3.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 Bone mineral density total vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 7 74658964 120536775 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293686 rat Bmd36 Bone mineral density QTL 36 15 7.4 1.0E-4 40084 D15Rat117 40882 D15Rat97 40084 D15Rat117 Bone mineral density ultimate force measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 15 38542355 78048493 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293687 rat Bss26 Bone structure and strength QTL 26 13 4.6 1.0E-4 39262 D13Rat86 Bone structure total area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 13 68910877 111154910 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293688 rat Bss29 Bone structure and strength QTL 29 15 5.31 1.0E-4 40084 D15Rat117 Bone structure cortical area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 15 16042557 61042557 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293689 rat Bss47 Bone structure and strength QTL 47 1 7.25 1.0E-4 36460 D1Rat69 Bone structure trabecular area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293690 rat Bss45 Bone structure and strength QTL 45 16 5.13 1.0E-4 40234 D16Rat60 Bone structure cortical area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 16 41581459 86581459 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293691 rat Bmd37 Bone mineral density QTL 37 15 6.6 1.0E-4 40084 D15Rat117 40882 D15Rat97 40882 D15Rat97 Bone mineral density energy to break measurements of femoral neck were taken increased bone mineral density Osteoporosis 2293456 18282130 15 38542355 78048493 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293693 rat Bss22 Bone structure and strength QTL 22 1 33.52 1.0E-4 36460 D1Rat69 Bone structure total area measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 1 176612333 221612333 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293694 rat Bss38 Bone structure and strength QTL 38 1 7.05 1.0E-4 37902 D1Rat169 Bone strength stiffness of the femur or the maximum slope of the force versus displacement curve abnormal bone structure Osteoporosis 2293455 18158281 1 207376933 252376933 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293696 rat Bmd32 Bone mineral density QTL 32 7 5.1 1.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 Bone mineral density polar moment of inertia measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 7 74658964 120536775 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293697 rat Bmd39 Bone mineral density QTL 39 8 38742 D8Rat111 35018 D8Rat15 Bone mineral density energy to break measurements of femoral neck were taken increased bone mineral density Osteoporosis 2293456 18282130 8 57109012 103548876 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293698 rat Bss43 Bone structure and strength QTL 43 10 5.33 1.0E-4 37900 D10Rat124 Bone structure total area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 10 62984501 107984501 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293699 rat Bss49 Bone structure and strength QTL 49 12 5.61 1.0E-4 39060 D12Rat30 Bone structure trabecular area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 12 11612769 46782294 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293700 rat Bmd27 Bone mineral density QTL 27 1 6.6 1.0E-4 37902 D1Rat169 36874 D1Rat82 37902 D1Rat169 Bone mineral density trabecular vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 1 229876870 249951685 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293701 rat Bmd34 Bone mineral density QTL 34 1 7.6 1.0E-4 37902 D1Rat169 36874 D1Rat82 37902 D1Rat169 Bone mineral density ultimate force measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 1 229876870 249951685 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293702 rat Bss34 Bone structure and strength QTL 34 13 4.61 1.0E-4 39262 D13Rat86 Bone structure polar moment of inertia (Ip) measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 13 68910877 111154910 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293703 rat Bss48 Bone structure and strength QTL 48 7 16.05 1.0E-4 37802 D7Rat78 Bone structure trabecular area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 7 98036672 143002779 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293704 rat Bss35 Bone structure and strength QTL 35 18 4.59 2.0E-4 38146 D18Rat50 Bone structure polar moment of inertia (Ip) measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 18 31347803 76347803 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293705 rat Bmd25 Bone mineral density QTL 25 10 7.1 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 Bone mineral density cortical vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density;increased cortical bone thickness Osteoporosis 2293456 18282130 10 51099067 85484602 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293706 rat Bmd20 Bone mineral density QTL 20 6 4.3 2.0E-4 35963 D6Rat46 35653 D6Rat42 35963 D6Rat46 Bone mineral density total vBMD measurements of femoral neck were taken from the peripheral quantitative computed tomography (pQCT) image increased bone mineral density Osteoporosis 2293456 18282130 6 13286615 19901481 1 - by flanking markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293707 rat Bss32 Bone structure and strength QTL 32 7 7.64 1.0E-4 35919 D7Rat23 Bone structure polar moment of inertia (Ip) measurements of femur were taken from the peripheral quantitative computed tomography (pQCT) image abnormal bone structure Osteoporosis 2293455 18158281 7 52159077 97159077 3 - by peak only 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293708 rat Bss46 Bone structure and strength QTL 46 18 8.8 1.0E-4 37578 D18Rat65 34975 D18Rat13 38146 D18Rat50 Bone structure cortical area measurements of lumbar 5 vertebrae were taken from peripheral quantitative computed tomography (pQCT) image abnormal bone strength Osteoporosis 2293455 18158281 18 12245097 87265094 2 - by one flank and peak markers 10011;734475 COP/OlaHsd;DA/OlaHsd intercross
2293833 rat Kiddil8 Kidney dilation QTL 8 2 2.9 35849 D2Rat62 36241 D2Rat72 38554 D2Rat112 Renal pathology kidney dilation degree of dilation of the renal pelvis was scored ranging from 0-10 Hydronephrosis 2293631 18523158 2 228663949 256217383 1 - by flanking markers 631594;1357985 BN/Rj;LOU/Ins backcross
2293835 rat Kiddil5 Kidney dilation QTL 5 2 3.8 37018 D2Rat14 36213 D2Rat40 41400 D2Rat216 Renal pathology kidney dilation degree of dilation of the right renal pelvis was scored ranging from 0-10 hematuria;hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis;Hematuria 2293631 18523158 2071 Agtr1b 2 118154358 163154358 4 - by one flank marker only 631594;1357985 BN/Rj;LOU/Ins backcross
2293837 rat Kiddil1 Kidney dilation QTL 1 6 3.7 33993 D6Mit2 38290 D6Rat76 38268 D6Rat102 Renal pathology kidney dilation degree of dilation of the left renal pelvis was scored ranging from 0-10 hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis 2293631 18523158 6 84287190 108790535 1 - by flanking markers 631594;1357985 BN/Rj;LOU/Ins backcross
2293839 rat Kiddil2 Kidney dilation QTL 2 6 4.8 35134 D6Rat41 33993 D6Mit2 42778 D6Rat171 Renal pathology kidney dilation degree of dilation of the left renal pelvis was scored ranging from 0-10 hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis 2293631 18523158 2859;1311209 Id2;Emilin1 6 20798926 84287337 1 - by flanking markers 631594;1357985 BN/Rj;LOU/Ins backcross
2293840 rat Kiddil9 Kidney dilation QTL 9 4 2.9 35278 D4Rat46 37592 D4Rat141 36898 D4Rat80 Renal pathology kidney dilation degree of dilation of the renal pelvis was scored ranging from 0-10 hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis 2293631 18523158 4 122550935 151158853 1 - by flanking markers 631594;1357985 BN/Rj;LOU/Ins backcross
2293841 rat Kiddil4 Kidney dilation QTL 4 6 4.4 35134 D6Rat41 33993 D6Mit2 42778 D6Rat171 Renal pathology kidney dilation degree of dilation of the renal pelvis was scored ranging from 0-10 hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis 2293631 18523158 2859;1311209 Id2;Emilin1 6 20798926 84287337 1 - by flanking markers 631594;1357985 BN/Rj;LOU/Ins backcross
2293842 rat Kiddil3 Kidney dilation QTL 3 6 4.3 33993 D6Mit2 38290 D6Rat76 38268 D6Rat102 Renal pathology kidney dilation degree of dilation of the renal pelvis was scored ranging from 0-10 hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis 2293631 18523158 6 84287190 108790535 1 - by flanking markers 631594;1357985 BN/Rj;LOU/Ins backcross
2293843 rat Kiddil6 Kidney dilation QTL 6 2 3.1 37018 D2Rat14 37672 D2Rat87 41400 D2Rat216 Renal pathology kidney dilation degree of dilation of the renal pelvis was scored ranging from 0-10 hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis 2293631 18523158 2071 Agtr1b 2 144377723 189377723 4 - by one flank marker only 631594;1357985 BN/Rj;LOU/Ins backcross
2293844 rat Kiddil7 Kidney dilation QTL 7 2 3.5 35849 D2Rat62 36241 D2Rat72 38554 D2Rat112 Renal pathology kidney dilation degree of dilation of the right renal pelvis was scored ranging from 0-10 hematuria;hydronephrosis;abnormal kidney pelvis morphology Hydronephrosis;Hematuria 2293631 18523158 2 228663949 256217383 1 - by flanking markers 631594;1357985 BN/Rj;LOU/Ins backcross
2306545 rat Iddm39 Insulin dependent diabetes mellitus QTL 39 4 43814 D4Got59 738065 D4Rhw6 Glucose level insulin-dependent blood glucose was measured decreased susceptibility to autoimmune diabetes;insulitis Diabetes Mellitus, Insulin-Dependent 2306526 19351909 4 76492967 76829366 1 - by flanking markers 2306543 BBDR.F344-(D4Got59-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw
2306547 rat Iddm38 Insulin dependent diabetes mellitus QTL 38 4 39266 D4Rat102 36181 D4Rat26 Glucose level insulin-dependent blood glucose was measured decreased susceptibility to autoimmune diabetes;insulitis Diabetes Mellitus, Insulin-Dependent 2306526 19351909 4 66220947 69183485 1 - by flanking markers 2306533 BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/2Rhw
2317577 rat Eae24 Experimental allergic encephalomyelitis QTL 24 4 37012 D4Rat25 60806 D4Wox7 36181 D4Rat26 Brain/spinal cord inflammation severity of disease experimental allergic encephalomyelitis was scored on a scale from 0-4 CNS inflammation Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 2317591 19675581 4 65821936 71729738 1 - by flanking markers 2307156;2307157 DA/ZtmKini;PVG.1AV1/Kini
2317586 rat Eae25 Experimental allergic encephalomyelitis QTL 25 4 9.300000190734863 11009 D4Wox21 42705 D4Rat265 43816 D4Got64 Brain/spinal cord inflammation severity of disease CNS inflammation;weight loss Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 2317591 19675581 4 78039509 82266081 1 - by flanking markers 2307156;2307157 DA/ZtmKini;PVG.1AV1/Kini
2317587 rat Eae26 Experimental allergic encephalomyelitis QTL 26 4 40586 D4Rat231 10560 D4Mit12 36462 D4Rat36 Brain/spinal cord inflammation severity of disease experimental allergic encephalomyelitis was scored on a scale from 0-4 CNS inflammation;weight loss Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 2317591 19675581 4 88462327 104416171 1 - by flanking markers 2307156;2307157 DA/ZtmKini;PVG.1AV1/Kini
2317588 rat Eae27 Experimental allergic encephalomyelitis QTL 27 4 10560 D4Mit12 39990 D4Rat177 40014 D4Rat233 Brain/spinal cord inflammation severity of disease experimental allergic encephalomyelitis was scored on a scale from 0-4 CNS inflammation Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 2317591 19675581 4 104415992 114074165 1 - by flanking markers 2307156;2307157 DA/ZtmKini;PVG.1AV1/Kini
2316896 rat Gluco57 Glucose level QTL 57 1 7.2 35945 D1Rat75 10805 D1Mgh13 Glucose level postprandial intraperitoneal glucose tolerance test (IPGTT) was administered increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 2316856 19584172 1 235098616 252340527 1 - by flanking markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316947 rat Rf58 Renal function QTL 58 7 7.0 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 Renal function structural damage of the kidney kidney failure Glomerulosclerosis, Focal;Kidney Failure;Diabetes Mellitus, Non-Insulin-Dependent 2316856 19584172 7 72552109 120746007 2 - by one flank and peak markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316949 rat Gluco60 Glucose level QTL 60 10 3.7 33585 D10Mit6 35254 D10Rat2 35503 D10Rat20 Glucose level postprandial intraperitoneal glucose tolerance test (IPGTT) was administered increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 2316856 19584172 10 14721135 110718848 2 - by one flank and peak markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316950 rat Scl66 Serum cholesterol level QTL 66 8 4.1 34062 D8Mgh2 33559 D8Mit5 35899 D8Rat47 Lipid level serum cholesterol kits from Sigma Diagnostics were used to determine the total cholesterol increased circulating cholesterol level Hyperlipidemia;Diabetes Mellitus, Non-Insulin-Dependent 2316856 19584172 8 32203499 110106272 1 - by flanking markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316952 rat Pur22 Proteinuria QTL 22 7 5.2 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 Renal function urine protein level Bradford method was used to determine the total protein concentration in the urine specimens for proteinuria increased protein excretion Diabetes Mellitus, Non-Insulin-Dependent;Proteinuria 2316856 19584172 7 72552109 120746007 2 - by one flank and peak markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316954 rat Rf57 Renal function QTL 57 5 7.0 33981 D5Mit4 34322 D5Mgh10 34144 D5Mgh11 Renal function structural damage of the kidney kidney failure Glomerulosclerosis, Focal;Kidney Failure;Diabetes Mellitus, Non-Insulin-Dependent 2316856 19584172 5 62098775 94515803 1 - by flanking markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316955 rat Stl24 Serum triglyceride level QTL 24 7 7.1 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 Lipid level serum triglyceride level kits from Sigma Diagnostics were used to determine the total triglycerides increased circulating triglyceride level Hyperlipidemia;Diabetes Mellitus, Non-Insulin-Dependent 2316856 19584172 7 72552109 120746007 2 - by one flank and peak markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316957 rat Pur21 Proteinuria QTL 21 5 6.2 35306 D5Rat26 34322 D5Mgh10 35144 D5Rat13 Renal function urine protein level Bradford method was used to determine the total protein concentration in the urine specimens for proteinuria increased protein excretion Diabetes Mellitus, Non-Insulin-Dependent;Proteinuria 2316856 19584172 additive 5 62098775 119332868 1 - by flanking markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316958 rat Gluco58 Glucose level QTL 58 4 10.0 35895 D4Rat1 37340 D4Rat84 35797 D4Rat16 Glucose level postprandial intraperitoneal glucose tolerance test (IPGTT) was administered increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 2316856 19584172 4 6690606 185398530 1 - by flanking markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316959 rat Gluco59 Glucose level QTL 59 5 4.7 35306 D5Rat26 11072 D5Mgh2 34144 D5Mgh11 Glucose level postprandial intraperitoneal glucose tolerance test (IPGTT) was administered increased circulating glucose level Diabetes Mellitus, Non-Insulin-Dependent;Hyperglycemia 2316856 19584172 recessive 5 17517235 119332868 1 - by flanking markers 10017;61498 GK/KyoSwe;BN/NHsdMcwi intercross
2316649 rat Bp344 Blood pressure QTL 344 1 2315162 D1Mco102 2315160 D1Mco129 Blood pressure systolic systolic blood pressure was measured by tail-cuff method decreased systemic arterial systolic blood pressure Hypotension 2312639 19423552 1309747;1310046 RGD1309747;Adamts16 2316654;2316655 SS.LEW-(D1Mco102-D1Mco129)/1Mco;SS.LEW-(D1Mco102-D1Mco129)/2Mco
2317027 rat Aia22 Adjuvant induced arthritis QTL 22 13 2.29 6.1 35975 D13Rat7 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 13 1 23584369 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317029 rat Aia19 Adjuvant induced arthritis QTL 19 10 2.98 8.8 41468 D10Rat155 36319 D10Rat26 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 10 70229781 110718848 4 - by one flank marker only 737926;737932 F344/NCrl;LEW/Crl intercross
2317030 rat Wbc5 White blood cell count QTL 5 8 3.21 0.005 9.0 42244 D8Arb6 White blood cell count white blood cell count was taken in 103/mm3 from the cardiac blood samples decreased leukocyte cell number Inflammatory Bowel Diseases;Leukopenia 2316974 19526527 recessive 8 10116155 55116155 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317032 rat Ginf2 Gastrointestinal inflammation QTL 2 8 3.21 0.005 9.0 41522 D8Rat164 Gastrointestinal inflammation liver granuloma determined on a scale of 0-4 intestinal inflammation;granulomatous inflammation Inflammatory Bowel Diseases;Enterocolitis 2316974 19526527 recessive 8 5914097 50914097 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317034 rat Aia9 Adjuvant induced arthritis QTL 9 13 4.62 12.8 35975 D13Rat7 40662 D13Rat113 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 13 1084268 33188609 1 - by flanking markers 737926;737932 F344/NCrl;LEW/Crl intercross
2317035 rat Aia16 Adjuvant induced arthritis QTL 16 7 2.71 9.5 36731 D7Rat24 37374 D7Rat99 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 737926;737932 F344/NCrl;LEW/Crl intercross
2317036 rat Livw3 Liver weight QTL 3 8 2.43 0.01 7.1 41522 D8Rat164 Liver weight liver was weighed (mg liver/g body weight) decreased liver weight Inflammatory Bowel Diseases 2316974 19526527 additive 8 5914097 50914097 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317038 rat Ginf3 Gastrointestinal inflammation QTL 3 17 2.89 0.005 8.4 37926 D17Rat62 Gastrointestinal inflammation liver granuloma determined on a scale of 0-4 intestinal inflammation;granulomatous inflammation Inflammatory Bowel Diseases;Enterocolitis 2316974 19526527 dominant 17 60979997 97296363 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317039 rat Aia6 Adjuvant induced arthritis QTL 6 10 4.31 13.8 41468 D10Rat155 36319 D10Rat26 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 recessive 10 70229781 110718848 4 - by one flank marker only 737926;737932 F344/NCrl;LEW/Crl intercross
2317040 rat Aia21 Adjuvant induced arthritis QTL 21 13 2.75 7.3 40662 D13Rat113 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 13 10688543 55688543 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317041 rat Aia14 Adjuvant induced arthritis QTL 14 2 3.29 8.6 36093 D2Rat26 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Arthritis, Rheumatoid;Inflammatory Bowel Diseases 2316974 19526527 additive 737926;737932 F344/NCrl;LEW/Crl intercross
2317042 rat Aia20 Adjuvant induced arthritis QTL 20 10 3.38 12.0 36319 D10Rat26 34274 D10Mgh5 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 10 41317054 86317054 4 - by one flank marker only 737926;737932 F344/NCrl;LEW/Crl intercross
2317043 rat Aia7 Adjuvant induced arthritis QTL 7 10 3.82 12.6 36319 D10Rat26 34274 D10Mgh5 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 10 41317054 86317054 4 - by one flank marker only 737926;737932 F344/NCrl;LEW/Crl intercross
2317044 rat Aia23 Adjuvant induced arthritis QTL 23 13 2.3 6.5 35975 D13Rat7 40662 D13Rat113 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 13 1084268 33188609 1 - by flanking markers 737926;737932 F344/NCrl;LEW/Crl intercross
2317045 rat Aia11 Adjuvant induced arthritis QTL 11 17 4.06 11.5 35585 D17Rat151 39044 D17Rat89 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 17 71569891 77806121 1 - by flanking markers 737926;737932 F344/NCrl;LEW/Crl intercross
2317046 rat Aia8 Adjuvant induced arthritis QTL 8 13 3.9700000286102295 10.399999618530273 40662 D13Rat113 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 13 10688543 55688543 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317047 rat Wbc4 White blood cell count QTL 4 7 0.01 38322 D7Rat63 White blood cell count white blood cell count was taken in 103/mm3 from the cardiac blood samples decreased leukocyte cell number Inflammatory Bowel Diseases;Leukopenia 2316974 19526527 7 1 36954656 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl
2317048 rat Ginf1 Gastrointestinal inflammation QTL 1 8 3.52 0.005 10.2 41522 D8Rat164 Gastrointestinal inflammation gut score gross gut score determined on a scale of 0-4 at necroscopy intestinal inflammation;granulomatous inflammation Inflammatory Bowel Diseases;Enterocolitis 2316974 19526527 recessive 8 5914097 50914097 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317050 rat Aia24 Adjuvant induced arthritis QTL 24 15 2.06 7.5 41636 D15Rat123 34222 D15Mgh8 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 15 58412001 80362100 1 - by flanking markers 737926;737932 F344/NCrl;LEW/Crl intercross
2317051 rat Aia18 Adjuvant induced arthritis QTL 18 8 2.42 10.3 42244 D8Arb6 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 8 10116155 55116155 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317052 rat Aia17 Adjuvant induced arthritis QTL 17 7 2.13 5.7 37374 D7Rat99 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 737926;737932 F344/NCrl;LEW/Crl intercross
2317053 rat Aia25 Adjuvant induced arthritis QTL 25 17 2.69 7.9 35585 D17Rat151 34120 D17Mgh5 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 17 59104944 71569891 1 - by flanking markers 737926;737932 F344/NCrl;LEW/Crl intercross
2317054 rat Aia12 Adjuvant induced arthritis QTL 12 17 4.24 11.0 35585 D17Rat151 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 17 49069974 94069974 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl
2317055 rat Aia10 Adjuvant induced arthritis QTL 10 15 3.41 8.9 40516 D15Rat106 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 recessive 15 83677810 109758846 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317056 rat Wbc3 White blood cell count QTL 3 5 2.51 0.01 36187 D5Rat30 White blood cell count white blood cell count was taken in 103/mm3 from the cardiac blood samples decreased leukocyte cell number Inflammatory Bowel Diseases;Leukopenia 2316974 19526527 recessive 5 112840801 157840801 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317057 rat Aia27 Adjuvant induced arthritis QTL 27 20 2.83 13.7 41562 D20Rat46 37888 D20Rat34 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 20 3039759 37383914 1 - by flanking markers 737926;737932 F344/NCrl;LEW/Crl intercross
2317058 rat Aia13 Adjuvant induced arthritis QTL 13 2 2.9 8.1 33620 D2Mit6 37664 D2Rat167 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 recessive 2 34118861 79118861 4 - by one flank marker only 737926;737932 F344/NCrl;LEW/Crl intercross
2317059 rat Aia15 Adjuvant induced arthritis QTL 15 7 2.46 7.4 36422 D7Rat26 34999 D7Rat44 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 dominant 7 21202126 66202126 4 - by one flank marker only 737926;737932 F344/NCrl;LEW/Crl intercross
2317060 rat Aia26 Adjuvant induced arthritis QTL 26 17 3.22 8.4 35585 D17Rat151 Joint/bone inflammation adjuvant induced joint diameter of the rear ankle was taken joint inflammation Inflammatory Bowel Diseases;Arthritis, Rheumatoid 2316974 19526527 17 49069974 94069974 3 - by peak only 737926;737932 F344/NCrl;LEW/Crl intercross
2317840 rat Alcrsp20 Alcohol response QTL 20 6 2.4000000953674316 0.63 37718 D6Rat90 Alcohol response baseline angle determined by the tilting plane test increased sensitivity to addictive substance;abnormal motor coordination/ balance Alcohol-Induced Disorders;Ataxia 2317807 19500156 1578694;1578715 AT;ANT intercross intercross
2317848 rat Alcrsp21 Alcohol response QTL 21 19 1.899999976158142 0.05 35376 D19Rat12 Alcohol response null baseline angle determined by the tilting plane test increased sensitivity to addictive substance;abnormal motor coordination/ balance Alcohol-Induced Disorders;Ataxia 2317807 19500156 19 4997213 49997213 3 - by peak only 1578694;1578715 AT;ANT intercross intercross
2317851 rat Alcrsp22 Alcohol response QTL 22 20 3.2 0.05 38324 D20Rat32 Alcohol response null baseline angle determined by the tilting plane test increased sensitivity to addictive substance;abnormal motor coordination/ balance;impaired righting response Alcohol-Induced Disorders;Ataxia 2317807 19500156 20 1 27477794 3 - by peak only 1578694;1578715 AT;ANT intercoss
2317833 rat Alcrsp19 Alcohol response QTL 19 1 12.4 0.001 36432 D1Rat35 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance;abnormal motor coordination/ balance;impaired righting response Alcohol-Induced Disorders;Ataxia 2317807 19500156 1 102248992 147248992 3 - by peak only 1578694;1578715 AT;ANT intercross
2317750 rat Glom26 Glomerulus QTL 26 15 4.3 38200 D15Rat54 41010 D15Rat96 41564 D15Rat80 Renal pathology urine protein level proteinuria was determined by the sulfosalicylic acid method glomerulonephritis Glomerulonephritis;Nephritis 2293335 16482158 15 14072029 71533203 1 - by flanking markers 1298093;1358112 LEW/NHsd;WKY/NCrl intercross
2317752 rat Glom23 Glomerulus QTL 23 2 3.6 40892 D2Rat234 35340 D2Rat70 38054 D2Rat138 Renal pathology urine protein level proteinuria was determined by the sulfosalicylic acid method glomerulonephritis Glomerulonephritis;Nephritis 2293335 16482158 2 201223893 254933362 1 - by flanking markers 1298093;1358112 LEW/NHsd;WKY/NCrl intercross
2317753 rat Glom24 Glomerulus QTL 24 5 3.1 35352 D5Rat33 35771 D5Rat22 35771 D5Rat22 Renal pathology glomerulus inflammation invitro assay to determine glomerular pathology of antibody-coated glomerular mesangial cells by macrophage-mediated killing glomerulonephritis Glomerulonephritis;Nephritis 2293335 16482158 5 102024381 143540180 1 - by flanking markers 1298093;1358112 LEW/NHsd;WKY/NCrl intercross
2317754 rat Glom25 Glomerulus QTL 25 10 3.5 41478 D10Rat186 38514 D10Rat105 38514 D10Rat105 Renal pathology urine protein level proteinuria was determined by the sulfosalicylic acid method glomerulonephritis Glomerulonephritis;Nephritis 2293335 16482158 10 86810917 110718848 3 - by peak only 1298093;1358112 LEW/NHsd;WKY/NCrl intercross
2317755 rat Glom22 Glomerulus QTL 22 1 3.8 36640 D1Rat14 36568 D1Rat4 39666 D1Rat246 Renal pathology urine protein level proteinuria was determined by the sulfosalicylic acid method glomerulonephritis Glomerulonephritis;Nephritis 2293335 16482158 1298093;1358112 LEW/NHsd;WKY/NCrl intercross
2317879 rat Alcrsp27 Alcohol response QTL 27 14 3.3 0.63 40342 D14Rat92 Alcohol response loss of righting reflex loss of righting reflex test increased sensitivity to addictive substance;abnormal motor coordination/ balance;impaired righting response Alcohol-Induced Disorders;Ataxia 2317807 19500156 14 62384564 107384564 3 - by peak only 1578694;1578715 AT;ANT intercross
2317880 rat Alcrsp25 Alcohol response QTL 25 20 2.3 37446 D20Rat54 Alcohol response baseline angle determined 30 minutes after the alcohol injection increased sensitivity to addictive substance;abnormal motor coordination/ balance Alcohol-Induced Disorders;Ataxia 2317807 19500156 20 18303073 55268282 3 - by peak only 1578694;1578715 AT;ANT intercross
2317882 rat Alcrsp24 Alcohol response QTL 24 8 3.2 0.05 36039 D8Rat58 Alcohol response baseline angle determined 30 minutes after the alcohol injection increased sensitivity to addictive substance;abnormal motor coordination/ balance Alcohol-Induced Disorders;Ataxia 2317807 19500156 8 1 25539735 3 - by peak only 1578694;1578715 AT;ANT intercross
2317883 rat Alcrsp26 Alcohol response QTL 26 3 1.8 0.63 36745 D3Rat1 Alcohol response 30 minutes ataxic sensitivity was calculated as the difference between the average angle of sliding pre-and post alcohol injection increased sensitivity to addictive substance;abnormal motor coordination/ balance Alcohol-Induced Disorders;Ataxia 2317807 19500156 3 147516452 171063335 3 - by peak only 1578694;1578715 AT;ANT intercross
2317885 rat Alcrsp28 Alcohol response QTL 28 2 2.1 0.63 36574 D2Rat68 Alcohol response Blood ethanol concentration mean blood ethanol concentration at regain of righting reflex increased sensitivity to addictive substance;abnormal motor coordination/ balance Alcohol-Induced Disorders;Ataxia 2317807 19500156 2 222136025 258207540 3 - by peak only 1578694;1578715 AT;ANT intercross
2317886 rat Alcrsp23 Alcohol response QTL 23 2 2.4 0.63 42596 D2Rat339 Alcohol response baseline angle determined 30 minutes after the alcohol injection increased sensitivity to addictive substance;abnormal motor coordination/ balance Alcohol-Induced Disorders;Ataxia 2317807 19500156 1578694;1578715 AT;ANT intercross
2324617 rat Coatc2 Coat color QTL 2 14 0.001 90.0 38932 D14Rat36 36287 D14Rat12 45176 D14Got40 Coat color hooded ratio of pigmented coat area in parental, F1 and F2 were measured abnormal coat/hair pigmentation 2317982 20364790 recessive 14 33039698 41707592 1 - by flanking markers 1302631;1302729 BN/SsNSlc;LEA/Tj intercross
2324619 rat Coatc4 Coat color QTL 4 17 0.001 18.0 35176 D17Rat2 38772 D17Rat102 Coat color hooded ratio of pigmented coat area in parental, F1 and F2 were measured abnormal coat/hair pigmentation 2317982 20364790 17 9988620 27118575 1 - by flanking markers 1302631;1302729 BN/SsNSlc;LEA/Tj intercross
2324620 rat Coatc3 Coat color QTL 3 15 7.0 36313 D15Rat5 35611 D15Rat11 35120 D15Rat6 Coat color hooded ratio of pigmented coat area in parental, F1 and F2 were measured abnormal coat/hair pigmentation 2317982 20364790 15 22452603 51526246 1 - by flanking markers 1302631;1302729 BN/SsNSlc;LEA/Tj intercross
2324621 rat Coatc5 Coat color QTL 5 17 9.0 36225 D17Rat15 35687 D17Rat47 10349 D17Arb7 Coat color hooded ratio of pigmented coat area in parental, F1 and F2 were measured abnormal coat/hair pigmentation 2317982 20364790 17 37727971 85072475 1 - by flanking markers 1302631;1302729 BN/SsNSlc;LEA/Tj intercross
2325725 rat Eae31 Experimental allergic encephalomyelitis QTL 31 1 39006 D1Rat193 35851 D1Rat68 Brain/spinal cord inflammation severity determined by scoring animals for degree of tail and limb paralysis on a scale of 0-5 CNS inflammation Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 2324646 20072140 2899;1304950 Il4ra;Il21r 1 183163129 193070197 1 - by flanking markers 2298494;2306784 Kini:DA,PVG-G10;Kini:DA,PVG-G12 intercross
2325726 rat Eae30 Experimental allergic encephalomyelitis QTL 30 1 39316 D1Rat217 40922 D1Rat270 Brain/spinal cord inflammation severity determined by scoring animals for degree of tail and limb paralysis on a scale of 0-5 CNS inflammation Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 2324646 20072140 1311983 Rgma 1 124308081 130290315 1 - by flanking markers 2298494;2306784 Kini:DA,PVG-G10;Kini:DA,PVG-G12 intercross
2325727 rat Pia41 Pristane induced arthritis QTL 41 1 39006 D1Rat193 1629174 D1Got334 Joint/bone inflammation pristane induced pristane was injected intradermally at the base of the tail; arthritis development was monitored using a microscopic scoring system for each of the four limbs in the entire paw; maximum total score is thus 16 for each rat by adding up the escores from four paws; rats were observed 1-3 times a week during the experimental period. CNS inflammation;increased susceptibility to induced arthritis;joint swelling Arthritis, Rheumatoid;Multiple Sclerosis 2324646 20072140 2899;1304950 Il4ra;Il21r 1 183163129 228163129 4 - by one flank marker only 2298494;2306784 Kini:DA,PVG-G10;Kini:DA,PVG-G12
2325836 rat Bp346 Blood pressure QTL 346 10 0.001 44781 D10Got112 2875 Igfbp4 Blood pressure mean arterial telemetry probes were implanted and systolic, diastolic and mean arterial blood pressures measured decreased mean systemic arterial blood pressure Hypotension 2301185 18806617 10 79857808 87834315 1 - by flanking markers 2325798 SS.LEW-(D10Got112-Igfbp4)/Ayd
2325838 rat Bp347 Blood pressure QTL 347 16 0.001 1358040 D16Chm36 1358041 D16Chm60 Blood pressure mean arterial telemetry probes were implanted and systolic, diastolic and mean arterial blood pressures measured decreased mean systemic arterial blood pressure Hypotension 2301185 18806617 2325801;2325803 SS.LEW-(D16Chm36-D16Mit2)/Ayd;SS.LEW-(D16Rat112-D16Chm60)/Ayd
2325839 rat Bp348 Blood pressure QTL 348 18 0.001 1579149 D18Chm3 1579055 D18Chm52 Blood pressure mean arterial telemetry probes were implanted and systolic, diastolic and mean arterial blood pressures measured decreased mean systemic arterial blood pressure Hypotension 2301185 18806617 2301381;2301385 SS.LEW-(D18Chm41-D18Rat92)/Ayd;SS.LEW-(D18Rat29-D18Rat55)/Ayd
2325840 rat Bp345 Blood pressure QTL 345 3 0.001 10260 D3Rat52 728024 D3Chm57 Blood pressure mean arterial telemetry probes were implanted and systolic, diastolic and mean arterial blood pressures measured decreased mean systemic arterial blood pressure Hypotension 2301185 18806617 3 14051872 24716931 1 - by flanking markers 2325796 SS.LEW-(D3Rat52-D3Chm57)/Ayd
4889451 rat Eae29 Experimental Autoimmune Encephalomyelitis QTL 29 1 5.51 39234 D1Rat248 35685 D1Rat10 43193 D1Got11 Brain/spinal cord inflammation severity of disease experimental allergic encephalomyelitis was scored on a scale from 0-4 CNS inflammation Multiple Sclerosis;Encephalomyelitis, Experimental Autoimmune 4888518 21041731 1303169 Il22ra2 1 6253932 25271177 1 - by flanking markers 4889450 DA.PVG.1AV1-(D1Rat248-D1Rat10)/Kini
4889419 rat Cstrr2 Cold stress response QTL 2 1 0.05 38112 D1Rat171 11019 D1Wox33 Hormone level norepinephrine Measurement of urinary excretion of norepinephrine (NE) determined by high-performance liquid chromatography increased circulating noradrenaline level;abnormal sensory capabilities/reflexes/nociception Hypertension;Stress;Autonomic Nervous System Diseases 4889147 21063213 1 158964262 203964262 4 - by one flank marker only 4889411 SHRSP.WKY-(D1Smu13-D1Wox33)/Izm
4889428 rat Stresp24 Stress response QTL 24 1 0.05 38112 D1Rat171 11019 D1Wox33 Stress response null Measurement of urinary excretion of norepinephrine (NE) determined by high-performance liquid chromatography and relative sympathetic activity determined by the heart rate variability increased circulating noradrenaline level;abnormal sensory capabilities/reflexes/nociception Hypertension;Stress;Autonomic Nervous System Diseases 4889147 21063213 1 158964262 203964262 4 - by one flank marker only 4889411 SHRSP.WKY-(D1Smu13-D1Wox33)/Izm
4889511 rat Gluco61 Glucose level QTL 61 4 4.7 0.001 39194 D4Rat115 41888 D4Rat282 43767 D4Got15 Glucose level oral glucose tolerance test (OGTT) increased circulating glucose level;decreased circulating insulin level;decreased pancreas weight Diabetes Mellitus, Experimental 2326163 20530722 621465;1584719 Ica1;Ndufa4 4 34206019 38029988 1 - by flanking markers 1357181;1357191 CDR/Ygl;CDS/Ygl
4889521 rat Gluco62 Glucose level QTL 62 11 2.82 0.001 40158 D11Rat65 39356 D11Rat41 35955 D11Rat38 Glucose level null oral glucose tolerance test (OGTT) at 30 and 60 min increased circulating glucose level;decreased circulating insulin level;decreased pancreas weight Diabetes Mellitus, Experimental 2326163 20530722 11 56625258 67465962 2 - by one flank and peak markers 1357181;1357191 CDR/Ygl;CDS/Ygl
4889606 rat Gluco63 Glucose level QTL 63 13 2.86 0.003 37554 D13Rat57 34124 D13Mgh6 Glucose level oral glucose tolerance test (OGTT) at 30, 60 and 120 min increased circulating glucose level;decreased circulating insulin level;decreased pancreas weight Diabetes Mellitus, Experimental 2326163 20530722 13 84280242 111154910 2 - by one flank and peak markers 1357181;1357191 CDR/Ygl;CDS/Ygl
4889610 rat Pancm3 Pancreatic morphology QTL 3 20 3.75 0.001 35657 D20Rat5 37792 D20Rat29 37652 D20Rat26 pancreas weight pancreas was weighed after OGTT increased pancreas weight Diabetes Mellitus, Experimental 2326163 20530722 20 18411845 48055886 1 - by flanking markers 1357181;1357191 CDR/Ygl;CDS/Ygl
4889834 rat Pur24 Proteinuria QTL 24 2 5.8 0.014 34234 D2Mgh9 34461 D2Mgh12 10712 D2Mgh10 Renal function urine protein level urinary protein concentration determined colorimetrically by microprotein-PR method and 24-h urinary excretion rate was calculated increased protein excretion Proteinuria 4889613 20876844 recessive 2 191378142 210636169 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
4889848 rat Pur25 Proteinuria QTL 25 6 14.0 0.003 36452 D6Rat25 40588 D6Rat165 34306 D6Mgh5 Renal function urine protein level urinary protein concentration determined colorimetrically by microprotein-PR method and 24-h urinary excretion rate was calculated increased protein excretion Proteinuria 4889613 20876844 recessive 6 58941174 93819252 2 - by one flank and peak markers 631572;631573 SBH/Ygl;SBN/Ygl
4889852 rat Pur26 Proteinuria QTL 26 9 15.0 0.001 33999 D9Mit5 40510 D9Rat109 34088 D9Mgh2 Renal function urine protein level urinary protein concentration determined colorimetrically by microprotein-PR method and 24-h urinary excretion rate was calculated increased protein excretion Proteinuria 4889613 20876844 recessive 9 75633467 100495220 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
4889857 rat Pur27 Proteinuria QTL 27 20 12.2 0.001 37594 D20Rat41 35657 D20Rat5 38324 D20Rat32 Renal function urine protein level urinary protein concentration determined colorimetrically by microprotein-PR method and 24-h urinary excretion rate was calculated increased protein excretion Proteinuria 4889613 20876844 2231;3426;69418;628596 C2;Psmb8;Ubd;Tubb5 recessive 20 4740609 18411969 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
4889859 rat Pur28 Proteinuria QTL 28 11 19.5 0.001 36095 D11Rat7 34118 D11Mgh2 35955 D11Rat38 Renal function urine protein level urinary protein concentration determined colorimetrically by microprotein-PR method and 24-h urinary excretion rate was calculated increased protein excretion Proteinuria 4889613 20876844 recessive 11 46499941 77591279 2 - by one flank and peak markers 631572;631573 SBH/Ygl;SBN/Ygl
4889861 rat Pur29 Proteinuria QTL 29 13 13.8 0.005 34351 D13Mgh4 37554 D13Rat57 37844 D13Rat85 Renal function urine protein level urinary protein concentration determined colorimetrically by microprotein-PR method and 24-h urinary excretion rate was calculated increased protein excretion Proteinuria 4889613 20876844 recessive 13 38489801 84280390 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
4889870 rat Pur30 Proteinuria QTL 30 20 19.0 0.005 37632 D20Rat49 39998 D20Rat64 43144 D20Rat67 Renal function urine protein level urinary protein concentration determined colorimetrically by microprotein-PR method and 24-h urinary excretion rate was calculated increased protein excretion Proteinuria 4889613 20876844 2231;3426;69418;628596 C2;Psmb8;Ubd;Tubb5 recessive 20 8286533 28734502 1 - by flanking markers 631572;631573 SBH/Ygl;SBN/Ygl
4889891 rat Eae32 Experimental allergic encephalomyelitis QTL 32 17 4.8 2.0E-4 34827 D17Rat12 45464 D17Got49 45469 D17Got45 Brain/spinal cord inflammation onset of disease incidence of Eae, cumulative score and maximum score was determined CNS inflammation Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 4889889;629629 20856809;12517974 1306984 Btn1a1 17 33277173 42659722 1 - by flanking markers 2298494 Kini:DA,PVG-G10
4889894 rat Eae33 Experimental allergic encephalomyelitis QTL 33 17 5.2 1.0E-4 34120 D17Mgh5 38092 D17Rat95 60143 D17Got120 Brain/spinal cord inflammation onset of disease incidence of Eae, cumulative score and maximum score was determined CNS inflammation Encephalomyelitis, Experimental Autoimmune;Multiple Sclerosis 4889889;629629 20856809;12517974 3831 Zeb1 17 59104847 66993271 1 - by flanking markers 2298494;4889890 Kini:DA,PVG-G10;DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini
4889919 rat Bss86 Bone structure and strength QTL 86 1 4.1 36610 D1Rat20 10442 D1Wox16 Bone structure null periosteal area at midshaft (PAmid) of tibia is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 1 48777689 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889929 rat Bss87 Bone structure and strength QTL 87 1 6.7 36610 D1Rat20 10442 D1Wox16 Bone structure null endosteal area at fibula-site (EAfib) is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 1 48777689 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889933 rat Bss88 Bone structure and strength QTL 88 6 3.8 34184 D6Mgh11 33897 D3Mit19 Bone structure total bone volume (TotBV) of tibia is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889938 rat Bss89 Bone structure and strength QTL 89 8 3.8 33973 D8Mit2 34310 D8Mgh4 Bone structure null cortical bone volume (CortBV) of tibia is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 8 53049279 86628010 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889943 rat Bss90 Bone structure and strength QTL 90 9 4.1 34184 D6Mgh11 33897 D3Mit19 Bone structure null endosteal area at fibula-site (EAfib) is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889948 rat Bss91 Bone structure and strength QTL 91 10 4.0 34274 D10Mgh5 34485 D10Mgh4 Bone structure null periosteal area at midshaft (PAmid) of tibia is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 10 86316831 96799937 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889951 rat Bss92 Bone structure and strength QTL 92 14 3.9 10773 D14Mit10 35897 D14Rat22 Bone structure null cortical area at fibula-site (CAfib) is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 14 87960277 102509397 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889955 rat Bss93 Bone structure and strength QTL 93 17 4.4 34827 D17Rat12 10348 D17Mit4 Bone structure null cortical bone volume fraction (CortBV/TotBV) of tibia is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 17 33277173 71214857 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889962 rat Bss94 Bone structure and strength QTL 94 1 3.8 33660 D1Mit9 10442 D1Wox16 Bone structure endosteal area at fibia-site (EAfib) is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 1 43840481 81947972 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889966 rat Bss95 Bone structure and strength QTL 95 3 4.4 33782 D3Mit10 36047 D3Rat46 Bone structure periosteal area at fibia-site (PAfib) is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 3 1 33871290 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889969 rat Bss96 Bone structure and strength QTL 96 4 4.9 33656 D4Mit9 11015 D4Mit24 Bone structure cortical bone volume (CortBV) of tibia is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 4 54828069 78039637 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889972 rat Bss97 Bone structure and strength QTL 97 4 5.6 33656 D4Mit9 11015 D4Mit24 Bone structure total bone volume (TotBV) of tibia is determined by three-dimensional computed tomography (3DCT) decreased bone strength Osteoporosis 4889918 20699128 4 54828069 78039637 1 - by flanking markers 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4889975 rat Bmd81 Bone mineral density QTL 81 3 4.3 37588 D3Rat189 11260 D3Mit8 Bone mineral density total bone mineral density (TotBMD) is determined by three-dimensional computed tomography (3DCT) increased bone mineral density Osteoporosis 4889918 20699128 3 35797577 80797577 4 - by one flank marker only 10017;2302067 GK/KyoSwe;F344/DuCrlSwe
4145117 rat Mcs27 Mammary carcinoma susceptibility QTL 27 13 1.0E-4 41346 D13Rat123 37314 D13Rat101 Mammary tumor susceptibility number of mammary tumors after 15 weeks of induction mammary adenocarcinoma Mammary Neoplasms, Experimental 4143380 20737482 13 44872181 49428577 1 - by flanking markers 2293145 SS.BN-(D13Rat123-D13Rat101)/Mcwi intercross
4145118 rat Mcs26 Mammary carcinoma susceptibility QTL 26 6 1.0E-4 40144 D6Rat119 42200 D6Arb3 Mammary tumor susceptibility number of mammary tumors after 15 weeks of induction mammary adenocarcinoma Mammary Neoplasms, Experimental 4143380 20737482 6 111239053 138260635 1 - by flanking markers 4145088 SS.BN-(D6Rat119-D6Arb3)/Mcwi intercross
4145119 rat Mcs25 Mammary carcinoma susceptibility QTL 25 6 1.0E-4 39716 D6Rat149 35198 D6Rat11 Mammary tumor susceptibility number of mammary tumors after 15 weeks of induction mammary adenocarcinoma Mammary Neoplasms, Experimental 4143380 20737482 6 7161389 52161389 4 - by one flank marker only 4145090;4145091 SS.BN-(D6Rat149-D6Got171)/Mcwi;SS.BN-(D6Rat149-D6Arb3)/Mcwi intercross
4889492 rat Pancm2 Pancreatic morphology QTL 2 10 3.2 44840 D10Got156 Pancreatic morphology beta cell area was the ratio between the area of insulin-positive cells and total pancreatic section; beta-cell mass was calculated by multiplying this area by the weight of the pancreatic region decreased pancreatic beta cell mass Diabetes Mellitus, Non-Insulin-Dependent 4889455 20878524 10 81350126 110718848 3 - by peak only 737972;4889464 BN/Crl;GK/Ox intercross
4889494 rat Scort2 Serum corticosterone level QTL 2 1 4.2 1634688 D1Got308 Hormone level corticosterone rat corticosterone EIA kit was used to determine plasma corticosterone level decreased circulating corticosterone level Diabetes Mellitus, Non-Insulin-Dependent 4889455 20878524 737972;4889464 BN/Crl;GK/Ox intercross