From nobody at no-reply.mcw.edu Fri Apr 21 13:20:14 2000 From: nobody at no-reply.mcw.edu (jlaakso@healthtech.com) Date: Fri, 21 Apr 2000 12:20:14 -0600 Subject: [rat-forum] Animal Models conference, 1st Announcement Message-ID: FIRST ANNOUNCEMENT AND CALL FOR PAPERS
Cambridge Healthtech Institute's
Application of
GENOMICS TO ANIMAL MODELS
for Pharmaceutical Studies
November 15-16, 2000, Boston, Massachusetts
Conveniently scheduled immediately following CHI's Functional Genomics Conference

With the on-going sequencing of the genomes of several animal species ranging from Drosophila and zebra fish to rats and mice, their simpler genomes have given researchers a tool for exploring gene function as applied to the more extensive human genome. The use of genetically engineered rats and mice to explore the function of genes and for the selection of appropriate drug targets holds great promise in speeding the development of valuable therapies. These models provide effective ways to test new drug compounds, as well as aiding in our understanding of specific disease processes. This conference will explore the use of these animal models in pharmaceutical studies.

Topics which may be included are:
=B7      &nbs= p;Use of animal models to accelerate target identification
=B7       Methods to produce animal models quickly and efficiently
=B7       Utilizing rat, mouse or zebra fish genomes to isolate target genes
=B7       Selection of appropriate models
=B7       Prioritizing targets
=B7       Models for specific diseases

Researchers are encouraged to submit a title and one-page abstract for consideration for oral and poster presentations. Also, please include a short 3-5 sentence summary of your data, suitable for use in the program brochure should your abstract be selected for oral presentation. Please include full contact information for the presenter. Abstracts are subject to review by the Scientific Advisory Board.

Fax or e-mail submissions to:
Elizabeth Lamb, Conference Director
Cambridge Healthtech Institute
Fax: 207-493-4573
E-mail: elamb at healthtech.com

For more information:
Cambridge Healthtech Institute
1037 Chestnut Street
Newton Upper Falls, MA  02464
Ph: 617-630-1300
Fax: 617-630-1325
E-mail: jlaakso at healthtech.com
http://www.healthtech.com/conference/00anm


From carlisles at aecl.ca Fri Apr 14 09:38:23 2000 From: carlisles at aecl.ca (Sara Carlisle) Date: Fri, 14 Apr 2000 08:38:23 -0600 Subject: [rat-forum] rat respiratory volume and rate Message-ID: I am looking for information or relevant literature on the tidal volume and respiration rate of rats, especially with respect to how this changes with age/mass. So far, all we've been able to track down is some general information in "The Laboratory Rat Book" Vol 1. which indicates that a resp. rate of 85 per minute produces an average tidal volume of 1.5 ml, equivalent to about 75-130 ml per min, but gives no mention of weights, ages etc. The rats we will be using are Charles River hairless rats, aged from about 4 - 6 months, so this is the age range we are particularly interested in. Thanks for your help, Sara M. Carlisle Radiation Biology and Health Physics Branch AECL, Chalk River Laboratories Chalk River, ON K0J 1J0 Canada carlisles at aecl.ca phone (613) 584-8811 Extn 3667 fax (613) 584-1713 From nobody at no-reply.mcw.edu Fri Apr 21 11:49:42 2000 From: nobody at no-reply.mcw.edu (dab22@cdhg.psu.edu) Date: Fri, 21 Apr 2000 10:49:42 -0600 Subject: [rat-forum] Re: rat respiratory volume and rate Message-ID: Dear Sara, The person who knows most about rat respiration (at least wrt to use of respirators) is Barry Dworkin of Hershey Medical College in PA. I think his email address is brd1 at psu.edu...His phone is 717-531-8560..He may be able to help you with the information you seek. Sincerely, David Blizard On Fri, 14 Apr 2000, Carlisle, Sara wrote: > I am looking for information or relevant literature on the tidal volume and > respiration rate of rats, especially with respect to how this changes with > age/mass. So far, all we've been able to track down is some general > information in "The Laboratory Rat Book" Vol 1. which indicates that a resp. > rate of 85 per minute produces an average tidal volume of 1.5 ml, equivalent > to about 75-130 ml per min, but gives no mention of weights, ages etc. > > The rats we will be using are Charles River hairless rats, aged from about 4 > - 6 months, so this is the age range we are particularly interested in. > > Thanks for your help, > > Sara M. Carlisle > Radiation Biology and Health Physics Branch > AECL, Chalk River Laboratories > Chalk River, ON K0J 1J0 > Canada > > carlisles at aecl.ca > phone (613) 584-8811 Extn 3667 > fax (613) 584-1713 > > --- > You are currently subscribed to rat-list as: DAB22 at HATTERAS.CDHG.PSU.EDU > > From mhammerm at im.wustl.edu Mon Apr 24 17:56:23 2000 From: mhammerm at im.wustl.edu (Marc Randall Hammerman) Date: Mon, 24 Apr 2000 16:56:23 -0600 Subject: [rat-forum] Distinct Nuclear/Cytoplasmic Markers for EM Studies Message-ID: Hello: Is anyone aware of a strain of rats, the cells of which (nucleus; = cytoplasm; membranes) have a distinct appearance that would permit a clear = distinction from the cells of related or unrelated rat strains on electron = microscopic examination?=20 Thanks Marc Hammerman Washington University From mhammerm at im.wustl.edu Tue Apr 25 18:29:19 2000 From: mhammerm at im.wustl.edu (Marc Randall Hammerman) Date: Tue, 25 Apr 2000 17:29:19 -0600 Subject: [rat-forum] Anti rat RT1AC Message-ID: Hello: Is anyone aware of a source of antibodies that can distinguish rat RT1-C = from RT1-AVL membrane antigen? I am interested in staining for MHC class = 1 antigen on endothelial cells of PVG rats. An antibody that works on = paraffin embedded sections would be best. Thanks Marc Hammerman Washington University From gilliii at massmed.org Wed Apr 26 12:44:32 2000 From: gilliii at massmed.org (Thomas J. Gill) Date: Wed, 26 Apr 2000 11:44:32 -0600 Subject: [rat-forum] Re: Anti rat RT1AC Message-ID: Contact Eberhard Guenther at eguenth at gwdg.de Tom Gill At 05:29 PM 04/25/2000 -0500, you wrote: >Hello: > >Is anyone aware of a source of antibodies that can distinguish rat RT1-C >from RT1-AVL membrane antigen? I am interested in staining for MHC class >1 antigen on endothelial cells of PVG rats. An antibody that works on >paraffin embedded sections would be best. > >Thanks > >Marc Hammerman >Washington University > > > > >--- >You are currently subscribed to rat-list as: GILLIII at MASSMED.ORG