# RGD-PIPELINE: ftp-file-extracts # MODULE: annotations-version-1.1.9 (Oct 10, 2019) # GENERATED-ON: 2024/04/27 # PURPOSE: annotations about active Dog objects extracted from RGD database # ONTOLOGY: ChEBI: ChEBI Ontology # CONTACT: rgd.data@mcw.edu # FORMAT: tab delimited text # NOTES: multiple values in a single column are separated by '|' # #COLUMN INFORMATION: # #1 RGD_ID unique RGD_ID of the annotated object #2 OBJECT_SYMBOL official symbol of the annotated object #3 OBJECT_NAME official name of the annotated object #4 OBJECT_TYPE annotated object data type: one of ['gene','qtl','strain'] #5 TERM_ACC_ID ontology term accession id #6 TERM_NAME ontology term name #7 QUALIFIER optional qualifier #8 EVIDENCE evidence #9 WITH with info #10 ASPECT aspect #11 REFERENCES db references (Reference RGDID|PUBMED ID) #12 CREATED_DATE created date #13 ASSIGNED_BY assigned by #14 MESH_OMIM_ID MESH:xxx or OMIM:xxx id corresponding to RDO:xxx id found in TERM_ACC_ID column (RGD/CTD Disease Ontology annotations only) #15 CURATION_NOTES curation notes provided by RGD curators #16 ORIGINAL_REFERENCE original reference RGD_ID OBJECT_SYMBOL OBJECT_NAME OBJECT_TYPE TERM_ACC_ID TERM_NAME QUALIFIER EVIDENCE WITH ASPECT REFERENCES CREATED_DATE ASSIGNED_BY MESH_OMIM_ID CURATION_NOTES ORIGINAL_REFERENCE 12050654 CMTM7 CKLF like MARVEL transmembrane domain containing 7 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CMTM7 mRNA PMID:22747577 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:16170 mercury(0) increases expression EXP E RGD:6480464 20191114 CTD MESH:D008628 Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein PMID:15590114 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:16170 mercury(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008628 ABCC1 protein affects the export of and results in decreased susceptibility to Mercury PMID:15590114 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:16978 leukotriene C4 affects transport EXP E RGD:6480464 20191114 CTD MESH:D017997 ABCC1 protein affects the transport of Leukotriene C4 PMID:12516967 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:25195 mercury atom increases expression EXP E RGD:6480464 20191114 CTD MESH:D008628 Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein PMID:15590114 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:25195 mercury atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008628 ABCC1 protein affects the export of and results in decreased susceptibility to Mercury PMID:15590114 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:28445 vincristine decreases response to substance EXP E RGD:6480464 20191114 CTD MESH:D014750 ABCC1 protein results in decreased susceptibility to Vincristine PMID:12516967 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:31823 mercury dichloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D008627 Mercuric Chloride results in increased expression of ABCC1 mRNA; Mercuric Chloride results in increased expression of ABCC1 protein PMID:15590114 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:31823 mercury dichloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008627 ABCC1 protein affects the export of and results in decreased susceptibility to Mercuric Chloride PMID:15590114 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:3303 calcein am affects export EXP E RGD:6480464 20191114 CTD MESH:C085925 ABCC1 protein affects the export of calcein AM PMID:12516967 12050846 ABCC1 ATP binding cassette subfamily C member 1 gene CHEBI:4911 etoposide decreases response to substance EXP E RGD:6480464 20191114 CTD MESH:D005047 ABCC1 protein results in decreased susceptibility to Etoposide PMID:12516967 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:16170 mercury(0) increases expression EXP E RGD:6480464 20191114 CTD MESH:D008628 Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein PMID:15590114 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:16170 mercury(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008628 ABCC2 protein affects the export of and results in decreased susceptibility to Mercury PMID:15590114 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:16469 17beta-estradiol affects transport EXP E RGD:6480464 20191114 CTD MESH:D004958 ABCC2 protein affects the transport of Estradiol PMID:15507541 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:16978 leukotriene C4 affects transport EXP E RGD:6480464 20191114 CTD MESH:D017997 ABCC2 protein affects the transport of Leukotriene C4 PMID:15507541 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:25195 mercury atom increases expression EXP E RGD:6480464 20191114 CTD MESH:D008628 Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein PMID:15590114 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:25195 mercury atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008628 ABCC2 protein affects the export of and results in decreased susceptibility to Mercury PMID:15590114 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:31823 mercury dichloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D008627 Mercuric Chloride results in increased expression of ABCC2 mRNA; Mercuric Chloride results in increased expression of ABCC2 protein PMID:15590114 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:31823 mercury dichloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008627 ABCC2 protein affects the export of and results in decreased susceptibility to Mercuric Chloride PMID:15590114 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:63621 saquinavir affects transport EXP E RGD:6480464 20191114 CTD MESH:D019258 ABCC2 protein affects the transport of Saquinavir PMID:12702717 12050879 ABCC2 ATP binding cassette subfamily C member 2 gene CHEBI:9436 Temocaprilat affects transport EXP E RGD:6480464 20191114 CTD MESH:C069156 ABCC2 protein affects the transport of temocaprilat PMID:15507541 12050914 MAPK9 mitogen-activated protein kinase 9 gene CHEBI:16240 hydrogen peroxide increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D006861 Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein PMID:23816505 12050914 MAPK9 mitogen-activated protein kinase 9 gene CHEBI:16240 hydrogen peroxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006861 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] PMID:23816505 12050914 MAPK9 mitogen-activated protein kinase 9 gene CHEBI:16856 glutathione multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005978 Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] PMID:23816505 12050914 MAPK9 mitogen-activated protein kinase 9 gene CHEBI:26710 sodium chloride increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased phosphorylation of MAPK9 protein PMID:23816505 12050914 MAPK9 mitogen-activated protein kinase 9 gene CHEBI:26710 sodium chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012965 Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] PMID:23816505 12050914 MAPK9 mitogen-activated protein kinase 9 gene CHEBI:28939 N-acetyl-L-cysteine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000111 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] PMID:23816505 12050914 MAPK9 mitogen-activated protein kinase 9 gene CHEBI:90695 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C432165 pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] PMID:23816505 12051364 LOC100686073 metallothionein-1 gene CHEBI:31823 mercury dichloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D008627 Mercuric Chloride results in increased expression of MT1 mRNA PMID:15590114 12051759 ATG7 autophagy related 7 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of ATG7 mRNA PMID:27255383 12051818 CA2 carbonic anhydrase 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of CA2 mRNA PMID:22747577 12052222 SERPINE2 serpin family E member 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of SERPINE2 mRNA PMID:22747577 12052559 PPARG peroxisome proliferator activated receptor gamma gene CHEBI:17154 nicotinamide increases expression EXP E RGD:6480464 20191114 CTD MESH:D009536 Niacinamide results in increased expression of PPARG protein PMID:22539994 12052559 PPARG peroxisome proliferator activated receptor gamma gene CHEBI:17154 nicotinamide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009536 Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein] PMID:22539994 12052559 PPARG peroxisome proliferator activated receptor gamma gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C059514 Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein] PMID:22539994 12052585 TJP1 tight junction protein 1 gene CHEBI:15367 all-trans-retinoic acid increases expression EXP E RGD:6480464 20191114 CTD MESH:D014212 Tretinoin results in increased expression of TJP1 mRNA; Tretinoin results in increased expression of TJP1 protein PMID:17035595 12052585 TJP1 tight junction protein 1 gene CHEBI:15367 all-trans-retinoic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014212 CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA] PMID:17035595 12052585 TJP1 tight junction protein 1 gene CHEBI:60579 calcium oxalate decreases expression EXP E RGD:6480464 20210907 CTD MESH:D002129 Calcium Oxalate results in decreased expression of TJP1 protein PMID:34147488|PMID:36349591 12052585 TJP1 tight junction protein 1 gene CHEBI:60579 calcium oxalate multiple interactions EXP E RGD:6480464 20210907 CTD MESH:D002129 Docetaxel inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]; Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein] PMID:34147488|PMID:36349591 12052585 TJP1 tight junction protein 1 gene CHEBI:8040 phalloidin multiple interactions EXP E RGD:6480464 20210907 CTD MESH:D010590 Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein] PMID:34147488 12053109 CYP1A2 cytochrome P450 family 1 subfamily A member 2 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of CYP1A2 mRNA PMID:19952500 12053109 CYP1A2 cytochrome P450 family 1 subfamily A member 2 gene CHEBI:8050 phenacetin affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D010615 CYP1A2 protein affects the metabolism of Phenacetin PMID:15801540 12053109 CYP1A2 cytochrome P450 family 1 subfamily A member 2 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of CYP1A2 mRNA PMID:19952500 12053380 AHCY adenosylhomocysteinase gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of AHCY protein PMID:19952500 12053380 AHCY adenosylhomocysteinase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of AHCY protein PMID:19952500 12053832 EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of EHHADH mRNA PMID:19952500 12054509 EIF5A2 eukaryotic translation initiation factor 5A2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of EIF5A2 mRNA PMID:22747577 12057161 MMP2 matrix metallopeptidase 2 gene CHEBI:15379 dioxygen multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D010100 Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein] PMID:18339021 12057161 MMP2 matrix metallopeptidase 2 gene CHEBI:17883 hydrogen chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D006851 Hydrochloric Acid results in increased expression of MMP2 protein PMID:18339021 12057161 MMP2 matrix metallopeptidase 2 gene CHEBI:17883 hydrogen chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006851 Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein] PMID:18339021 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:144353 diethyldithiocarbamic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004050 Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] PMID:8592870 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:17578 toluene affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D014050 CYP2E1 protein affects the metabolism of Toluene PMID:8592870 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:17578 toluene multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014050 Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]; Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] PMID:8592870 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:17847 p-cresol affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:C032538 CYP2E1 protein affects the metabolism of 4-cresol PMID:8592870 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:17987 benzyl alcohol affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D019905 CYP2E1 protein affects the metabolism of Benzyl Alcohol PMID:8592870 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:28054 o-cresol affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:C034047 CYP2E1 protein affects the metabolism of 2-cresol PMID:8592870 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of CYP2E1 protein PMID:19952500 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:5141 fomepizole multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C010238 Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] PMID:8592870 12058559 CYP2E1 cytochrome P450 family 2 subfamily E member 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of CYP2E1 mRNA PMID:19952500 12059801 CTSK cathepsin K gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CTSK mRNA PMID:22747577 12060061 HGF hepatocyte growth factor gene CHEBI:28748 doxorubicin decreases response to substance EXP E RGD:6480464 20191114 CTD MESH:D004317 HGF protein results in decreased susceptibility to Doxorubicin PMID:15688034 12060417 CPT2 carnitine palmitoyltransferase 2 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of CPT2 mRNA PMID:19952500 12060747 UGT2B31 UDP-glucuronosyltransferase UGT2B31 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20210119 CTD MESH:D010634 Phenobarbital results in increased expression of UGT2B4 protein PMID:19952500 12061939 CAPN1 calpain 1 gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of CAPN1 mRNA PMID:24582689 12061939 CAPN1 calpain 1 gene CHEBI:9241 spironolactone decreases expression EXP E RGD:6480464 20191114 CTD MESH:D013148 Spironolactone results in decreased expression of CAPN1 protein PMID:20082611 12062987 MAL2 mal, T cell differentiation protein 2 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of MAL2 mRNA PMID:27255383 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:16243 quercetin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011794 Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] PMID:15266218 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28077 rifampicin increases expression EXP E RGD:6480464 20191114 CTD MESH:D012293 Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein PMID:22620706 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28411 allicin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C006452 allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] PMID:15266218 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28445 vincristine affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D014750 ABCB1 protein affects the susceptibility to Vincristine PMID:24975508 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28445 vincristine increases export EXP E RGD:6480464 20191114 CTD MESH:D014750 ABCB1 protein results in increased export of Vincristine PMID:28093773 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28445 vincristine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014750 valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine] PMID:24975508 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28499 kaempferol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C006552 kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] PMID:15266218 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28748 doxorubicin affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D004317 ABCB1 protein affects the susceptibility to Doxorubicin PMID:24975508 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28748 doxorubicin increases expression EXP E RGD:6480464 20191114 CTD MESH:D004317 Doxorubicin results in increased expression of ABCB1 protein PMID:28093773 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:28748 doxorubicin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004317 valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] PMID:15492788|PMID:24975508 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:31516 Doramectin increases response to substance EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form results in increased susceptibility to doramectin; ABCB1 mutant form results in increased susceptibility to doramectin PMID:22834856|PMID:23186803|PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of TTR mRNA] PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:44658 okadaic acid increases transport EXP E RGD:6480464 20191114 CTD MESH:D019319 ABCB1 protein results in increased transport of Okadaic Acid PMID:24374049 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:45409 ritonavir multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D019438 allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] PMID:15266218 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:4551 digoxin increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form results in increased susceptibility to Digoxin; ABCB1 mutant form results in increased susceptibility to Digoxin PMID:16594604|PMID:23186803|PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]; [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]; MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog] PMID:20510202|PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:47519 ketoconazole decreases activity EXP E RGD:6480464 20191114 CTD MESH:D007654 Ketoconazole results in decreased activity of ABCB1 protein PMID:19754906 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:47519 ketoconazole decreases expression EXP E RGD:6480464 20191114 CTD MESH:D007654 Ketoconazole results in decreased expression of ABCB1 mRNA PMID:22620706 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:47519 ketoconazole multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007654 [Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi PMID:19754906 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:50345 milbemycin increases response to substance EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form results in increased susceptibility to moxidectin; ABCB1 mutant form results in increased susceptibility to moxidectin PMID:23186803|PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA] PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:5051 Fexofenadine hydrochloride decreases uptake EXP E RGD:6480464 20191114 CTD MESH:C093230 ABCB1 protein results in decreased uptake of fexofenadine PMID:18299336 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:5831 Hypaconitine increases transport EXP E RGD:6480464 20191114 CTD MESH:C058309 ABCB1 protein results in increased transport of hypaconitine PMID:23200901 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:5835 hypericin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C004965 hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] PMID:15266218 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:6078 ivermectin affects abundance EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 protein affects the abundance of Ivermectin PMID:20595473 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:6078 ivermectin increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form results in increased susceptibility to Ivermectin; ABCB1 mutant form results in increased susceptibility to Ivermectin; ABCB1 protein mutant form results in increased susceptibility to Ivermectin PMID:22834856|PMID:22924731|PMID:23186803|PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA] PMID:25419811 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:6532 loperamide affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D008139 ABCB1 protein affects the susceptibility to Loperamide PMID:25660379 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:6532 loperamide increases export EXP E RGD:6480464 20191114 CTD MESH:D008139 ABCB1 protein results in increased export of Loperamide PMID:28093773 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:6773 Mesaconitine increases transport EXP E RGD:6480464 20191114 CTD MESH:C019470 ABCB1 protein results in increased transport of mesaconitine PMID:23200901 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:6916 mexiletine increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D008801 ABCB1 mutant form results in increased susceptibility to Mexiletine PMID:16594604 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:77733 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014700 [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin PMID:20510202 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:78739 emodepside affects response to substance EXP E RGD:6480464 20191114 CTD MESH:C468987 ABCB1 protein affects the susceptibility to emodepside PMID:25660379 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:78761 ML-7 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C070571 [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] PMID:20510202 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:8828 rhodamine 123 increases export EXP E RGD:6480464 20191114 CTD MESH:D020112 ABCB1 protein results in increased export of Rhodamine 123 PMID:28093773 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:8985 SDZ PSC 833 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C070272 valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] PMID:15492788|PMID:24975508 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:9423 Technetium tc 99m sestamibi decreases transport EXP E RGD:6480464 20191114 CTD MESH:D017256 ABCB1 gene mutant form results in decreased transport of Technetium Tc 99m Sestamibi PMID:19754906 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:9423 Technetium tc 99m sestamibi multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D017256 [Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi PMID:19754906 12063362 ABCB1 ATP binding cassette subfamily B member 1 gene CHEBI:9948 verapamil multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014700 [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin PMID:20510202 12063579 LBX2 ladybird homeobox 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of LBX2 mRNA PMID:22747577 12064112 OAT ornithine aminotransferase gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of OAT protein PMID:32991862 12066106 PPP3CA protein phosphatase 3 catalytic subunit alpha gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of PPP3CA mRNA PMID:27255383 12066131 EDN2 endothelin 2 gene CHEBI:88212 lead(II) chloride increases secretion EXP E RGD:6480464 20191114 CTD MESH:C029891 lead chloride results in increased secretion of EDN2 protein PMID:15915659 12067089 SDCBP syndecan binding protein gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SDCBP mRNA PMID:27255383 12067598 CP ceruloplasmin gene CHEBI:18248 iron atom increases export EXP E RGD:6480464 20191114 CTD MESH:D007501 CP protein results in increased export of Iron PMID:16806171 12067598 CP ceruloplasmin gene CHEBI:18248 iron atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007501 [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] PMID:16806171 12067598 CP ceruloplasmin gene CHEBI:82664 iron(0) increases export EXP E RGD:6480464 20191114 CTD MESH:D007501 CP protein results in increased export of Iron PMID:16806171 12067598 CP ceruloplasmin gene CHEBI:82664 iron(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007501 [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] PMID:16806171 12067945 HSPA5 heat shock protein family A (Hsp70) member 5 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of HSPA5 protein PMID:32991862 12067945 HSPA5 heat shock protein family A (Hsp70) member 5 gene CHEBI:18320 1,4-dithiothreitol increases expression EXP E RGD:6480464 20191114 CTD MESH:D004229 Dithiothreitol metabolite results in increased expression of HSPA5 protein PMID:17416481 12067945 HSPA5 heat shock protein family A (Hsp70) member 5 gene CHEBI:29699 tunicamycin increases expression EXP E RGD:6480464 20191114 CTD MESH:D014415 Tunicamycin results in increased expression of HSPA5 protein PMID:17416481 12067945 HSPA5 heat shock protein family A (Hsp70) member 5 gene CHEBI:42106 L-1,4-dithiothreitol increases expression EXP E RGD:6480464 20191114 CTD MESH:D004229 Dithiothreitol metabolite results in increased expression of HSPA5 protein PMID:17416481 12067945 HSPA5 heat shock protein family A (Hsp70) member 5 gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of HSPA5 mRNA PMID:24582689 12067945 HSPA5 heat shock protein family A (Hsp70) member 5 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of HSPA5 protein PMID:19952500 12067945 HSPA5 heat shock protein family A (Hsp70) member 5 gene CHEBI:9516 thapsigargin increases expression EXP E RGD:6480464 20191114 CTD MESH:D019284 Thapsigargin results in increased expression of HSPA5 protein PMID:17416481 12068442 AKAP12 A-kinase anchoring protein 12 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of AKAP12 mRNA PMID:27255383 12071595 KCND3 potassium voltage-gated channel subfamily D member 3 gene CHEBI:17347 testosterone increases expression EXP E RGD:6480464 20191114 CTD MESH:D013739 Testosterone results in increased expression of KCND3 protein PMID:17054656 12071595 KCND3 potassium voltage-gated channel subfamily D member 3 gene CHEBI:4784 enalapril decreases expression EXP E RGD:6480464 20191114 CTD MESH:D004656 Enalapril results in decreased expression of KCND3 mRNA PMID:19732978 12071640 ADRA1A adrenoceptor alpha 1A gene CHEBI:135929 silodosin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C095285 silodosin binds to and results in decreased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] PMID:19371927 12071640 ADRA1A adrenoceptor alpha 1A gene CHEBI:8093 phenylephrine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D010656 Phenylephrine binds to and results in increased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] PMID:19371927 12071790 TRIM54 tripartite motif containing 54 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TRIM54 mRNA PMID:27255383 12071833 TNPO1 transportin 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of TNPO1 mRNA PMID:22747577 12072070 MYLK myosin light chain kinase gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] PMID:20510202 12072070 MYLK myosin light chain kinase gene CHEBI:78761 ML-7 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C070571 [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] PMID:20510202 12072547 CASP3 caspase 3 gene CHEBI:15367 all-trans-retinoic acid increases activity EXP E RGD:6480464 20191114 CTD MESH:D014212 Tretinoin results in increased activity of CASP3 protein PMID:16953078 12072547 CASP3 caspase 3 gene CHEBI:3441 carvedilol decreases activity EXP E RGD:6480464 20191114 CTD MESH:C043211 Carvedilol results in decreased activity of CASP3 protein PMID:12875697 12072547 CASP3 caspase 3 gene CHEBI:4629 diosgenin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004144 Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] PMID:25446497 12072547 CASP3 caspase 3 gene CHEBI:60579 calcium oxalate increases activity EXP E RGD:6480464 20191114 CTD MESH:D002129 Calcium Oxalate results in increased activity of CASP3 protein PMID:25446497 12072547 CASP3 caspase 3 gene CHEBI:60579 calcium oxalate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002129 Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] PMID:25446497 12072547 CASP3 caspase 3 gene CHEBI:6538 loratadine increases activity EXP E RGD:6480464 20191114 CTD MESH:D017336 Loratadine results in increased activity of CASP3 protein PMID:20570632 12072547 CASP3 caspase 3 gene CHEBI:9241 spironolactone decreases expression EXP E RGD:6480464 20191114 CTD MESH:D013148 Spironolactone results in decreased expression of CASP3 protein PMID:20082611 12072547 CASP3 caspase 3 gene CHEBI:9453 Terfenadine increases activity EXP E RGD:6480464 20191114 CTD MESH:D016593 Terfenadine results in increased activity of CASP3 protein PMID:20570632 12074068 VIM vimentin gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of VIM mRNA; ochratoxin A results in increased expression of VIM protein PMID:33543323 12074068 VIM vimentin gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of VIM protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein] PMID:33543323 12074886 BCL2 BCL2 apoptosis regulator gene CHEBI:17823 calcitriol affects expression EXP E RGD:6480464 20191114 CTD MESH:D002117 Calcitriol affects the expression of BCL2 protein PMID:16080513 12074886 BCL2 BCL2 apoptosis regulator gene CHEBI:9241 spironolactone increases expression EXP E RGD:6480464 20191114 CTD MESH:D013148 Spironolactone results in increased expression of BCL2 protein PMID:20082611 12075184 FAS Fas cell surface death receptor gene CHEBI:3441 carvedilol decreases expression EXP E RGD:6480464 20191114 CTD MESH:C043211 Carvedilol results in decreased expression of FAS PMID:12875697 12076208 MYPN myopalladin gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of MYPN mRNA PMID:27255383 12077453 CCL17 C-C motif chemokine ligand 17 gene CHEBI:15864 luteolin multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D047311 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL17 promoter PMID:33763461 12077453 CCL17 C-C motif chemokine ligand 17 gene CHEBI:69478 cannabidiol multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D002185 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL17 promoter PMID:33763461 12077464 UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 gene CHEBI:46195 paracetamol increases glucuronidation EXP E RGD:6480464 20191114 CTD MESH:D000082 UGT1A6 protein results in increased glucuronidation of Acetaminophen PMID:11903872 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:17747 bis(2-ethylhexyl) phthalate increases activity EXP E RGD:6480464 20191114 CTD MESH:D004051 Diethylhexyl Phthalate results in increased activity of NR1I3 protein PMID:27732639 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:223316 (+)-artemisinin increases activity EXP E RGD:6480464 20191114 CTD MESH:C031327 artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form PMID:21778469|PMID:27732639 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:223316 (+)-artemisinin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C031327 androstan-3-ol inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]; artemisinin inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form] PMID:21778469 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:24780 imidazoles decreases activity EXP E RGD:6480464 20191114 CTD MESH:D007093 Imidazoles results in decreased activity of NR1I3 protein alternative form PMID:21778469 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:24780 imidazoles multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007093 artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form] PMID:21778469 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:35727 triazoles increases activity EXP E RGD:6480464 20191114 CTD MESH:D014230 Triazoles results in increased activity of NR1I3 protein alternative form PMID:21778469 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:3764 clotrimazole affects binding EXP E RGD:6480464 20191114 CTD MESH:D003022 Clotrimazole binds to NR1I3 protein PMID:21778469 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:3764 clotrimazole increases activity EXP E RGD:6480464 20191114 CTD MESH:D003022 Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form PMID:21778469|PMID:27732639 12077895 NR1I3 nuclear receptor subfamily 1 group I member 3 gene CHEBI:47318 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime increases activity EXP E RGD:6480464 20191114 CTD MESH:C475093 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein mutant form PMID:21778469 12079702 IL6 interleukin 6 gene CHEBI:16412 lipopolysaccharide increases expression EXP E RGD:6480464 20220405 CTD MESH:D008070 Lipopolysaccharides results in increased expression of IL6 mRNA PMID:32899721 12079702 IL6 interleukin 6 gene CHEBI:16412 lipopolysaccharide multiple interactions EXP E RGD:6480464 20220405 CTD MESH:D008070 arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] PMID:32899721 12079702 IL6 interleukin 6 gene CHEBI:2682 amphotericin B increases expression EXP E RGD:6480464 20191114 CTD MESH:D000666 Amphotericin B results in increased expression of IL6 protein PMID:24105867 12079702 IL6 interleukin 6 gene CHEBI:2682 amphotericin B multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000666 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein] PMID:24105867 12079702 IL6 interleukin 6 gene CHEBI:29866 arsenite(3-) multiple interactions EXP E RGD:6480464 20220405 CTD MESH:C015001 arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] PMID:32899721 12079702 IL6 interleukin 6 gene CHEBI:47495 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases expression EXP E RGD:6480464 20191114 CTD MESH:C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein PMID:24105867 12079702 IL6 interleukin 6 gene CHEBI:47495 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein] PMID:24105867 12079702 IL6 interleukin 6 gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of IL6 mRNA PMID:33543323 12079702 IL6 interleukin 6 gene CHEBI:7719 ochratoxin A increases secretion EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased secretion of IL6 protein PMID:33543323 12080881 NFKBIA NFKB inhibitor alpha gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C059514 Resveratrol inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] PMID:21239502 12080881 NFKBIA NFKB inhibitor alpha gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of NFKBIA mRNA PMID:22747577 12082040 NT5E 5'-nucleotidase ecto gene CHEBI:3441 carvedilol increases activity EXP E RGD:6480464 20191114 CTD MESH:C043211 Carvedilol results in increased activity of NT5E protein PMID:15148268 12083733 HTR2B 5-hydroxytryptamine receptor 2B gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of HTR2B mRNA PMID:22747577 12085405 B4GALT7 beta-1,4-galactosyltransferase 7 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of B4GALT7 mRNA PMID:22747577 12085513 LRP8 LDL receptor related protein 8 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of LRP8 mRNA PMID:22747577 12085621 JAML junction adhesion molecule like gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of JAML mRNA PMID:22747577 12085800 MAPK8 mitogen-activated protein kinase 8 gene CHEBI:16240 hydrogen peroxide increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D006861 Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein PMID:23816505 12085800 MAPK8 mitogen-activated protein kinase 8 gene CHEBI:16240 hydrogen peroxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006861 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] PMID:23816505 12085800 MAPK8 mitogen-activated protein kinase 8 gene CHEBI:16856 glutathione multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005978 Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] PMID:23816505 12085800 MAPK8 mitogen-activated protein kinase 8 gene CHEBI:26710 sodium chloride increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased phosphorylation of MAPK8 protein PMID:23816505 12085800 MAPK8 mitogen-activated protein kinase 8 gene CHEBI:26710 sodium chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012965 Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] PMID:23816505 12085800 MAPK8 mitogen-activated protein kinase 8 gene CHEBI:28939 N-acetyl-L-cysteine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000111 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] PMID:23816505 12085800 MAPK8 mitogen-activated protein kinase 8 gene CHEBI:90695 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C432165 pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] PMID:23816505 12085918 LOC478702 tubulin beta-2B chain gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of TUBB2B mRNA PMID:27255383 12086515 CXCL8 C-X-C motif chemokine ligand 8 gene CHEBI:15379 dioxygen multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D010100 Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein] PMID:18339021 12086515 CXCL8 C-X-C motif chemokine ligand 8 gene CHEBI:17883 hydrogen chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D006851 Hydrochloric Acid results in increased expression of CXCL8 protein PMID:18339021 12086515 CXCL8 C-X-C motif chemokine ligand 8 gene CHEBI:17883 hydrogen chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006851 Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein] PMID:18339021 12086958 EIF3A eukaryotic translation initiation factor 3 subunit A gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of EIF3A protein PMID:22747577 12087520 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 [Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein PMID:18820026 12087520 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 gene CHEBI:6904 metoprolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008790 [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein PMID:18820026 12087520 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 gene CHEBI:87681 ranolazine affects expression EXP E RGD:6480464 20191114 CTD MESH:D000069458 Ranolazine affects the expression of ATP2A2 protein PMID:18820026 12087520 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 gene CHEBI:87681 ranolazine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000069458 [Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein PMID:18820026 12087575 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of HNRNPA2B1 protein PMID:32991862 12087674 EEF2 eukaryotic translation elongation factor 2 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of EEF2 protein PMID:32991862 12089460 ABCA5 ATP binding cassette subfamily A member 5 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ABCA5 mRNA PMID:22747577 12090670 DERL2 derlin 2 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of DERL2 mRNA PMID:27255383 12091856 ESR1 estrogen receptor 1 gene CHEBI:16469 17beta-estradiol affects expression EXP E RGD:6480464 20191114 CTD MESH:D004958 Estradiol affects the expression of ESR1 protein PMID:16483645 12091856 ESR1 estrogen receptor 1 gene CHEBI:17026 progesterone affects expression EXP E RGD:6480464 20191114 CTD MESH:D011374 Progesterone affects the expression of ESR1 protein PMID:16483645 12093199 ANK1 ankyrin 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of ANK1 mRNA PMID:27255383 12095224 IMMP2L inner mitochondrial membrane peptidase subunit 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of IMMP2L mRNA PMID:22747577 12095504 PRDX6 peroxiredoxin 6 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of PRDX6 protein PMID:19952500 12095504 PRDX6 peroxiredoxin 6 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of PRDX6 protein PMID:19952500 12096923 VPS41 VPS41 subunit of HOPS complex gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS41 mRNA PMID:27255383 12097421 SLCO1B2 solute carrier organic anion transporter family member 1B2 gene CHEBI:135946 sincalide increases transport EXP E RGD:6480464 20191114 CTD MESH:D012844 SLCO1B3 protein results in increased transport of Sincalide PMID:20079461 12097421 SLCO1B2 solute carrier organic anion transporter family member 1B2 gene CHEBI:17474 estrone 3-sulfate increases transport EXP E RGD:6480464 20191114 CTD MESH:C017296 SLCO1B3 protein results in increased transport of estrone sulfate PMID:20079461 12097421 SLCO1B2 solute carrier organic anion transporter family member 1B2 gene CHEBI:28865 taurocholic acid increases transport EXP E RGD:6480464 20191114 CTD MESH:D013656 SLCO1B3 protein results in increased transport of Taurocholic Acid PMID:20079461 12097421 SLCO1B2 solute carrier organic anion transporter family member 1B2 gene CHEBI:63836 bromosulfophthalein increases transport EXP E RGD:6480464 20191114 CTD MESH:D013448 SLCO1B3 protein results in increased transport of Sulfobromophthalein PMID:20079461 12097421 SLCO1B2 solute carrier organic anion transporter family member 1B2 gene CHEBI:73356 DPDPE increases transport EXP E RGD:6480464 20191114 CTD MESH:D020881 SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)- PMID:20079461 12097421 SLCO1B2 solute carrier organic anion transporter family member 1B2 gene CHEBI:791 17beta-estradiol 17-glucosiduronic acid increases transport EXP E RGD:6480464 20191114 CTD MESH:C025483 SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide PMID:20079461 12098737 LOC609402 hemoglobin subunit beta-like gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20240423 CTD MESH:C526575 masitinib results in increased expression of HBG1 mRNA PMID:22747577 12098749 PXYLP1 2-phosphoxylose phosphatase 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ACPL2 mRNA PMID:22747577 12099137 ANXA6 annexin A6 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ANXA6 protein PMID:22747577 12100173 ANXA1 annexin A1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ANXA1 protein PMID:22747577 12101384 HEBP2 heme binding protein 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of HEBP2 mRNA PMID:22747577 12101396 DLST dihydrolipoamide S-succinyltransferase gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of DLST protein PMID:19952500 12101885 ATG4D autophagy related 4D cysteine peptidase gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of ATG4D mRNA PMID:27255383 12101969 CORO1A coronin 1A gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CORO1A protein PMID:22747577 12102553 PCM1 pericentriolar material 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PCM1 mRNA PMID:22747577 12103247 RABEPK Rab9 effector protein with kelch motifs gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of RABEPK mRNA PMID:27255383 12104718 PRPS2 phosphoribosyl pyrophosphate synthetase 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of PRPS2 mRNA PMID:22747577 12105831 SLC18A2 solute carrier family 18 member A2 gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC18A2 mRNA] PMID:25419811 12105831 SLC18A2 solute carrier family 18 member A2 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA] PMID:25419811 12105831 SLC18A2 solute carrier family 18 member A2 gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA] PMID:25419811 12105831 SLC18A2 solute carrier family 18 member A2 gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA] PMID:25419811 12106395 AVP arginine vasopressin gene CHEBI:2453 acyclovir decreases activity EXP E RGD:6480464 20191114 CTD MESH:D000212 Acyclovir results in decreased activity of AVP protein PMID:2724137 12106395 AVP arginine vasopressin gene CHEBI:41879 dexamethasone decreases expression EXP E RGD:6480464 20191114 CTD MESH:D003907 Dexamethasone results in decreased expression of AVP protein PMID:1934541 12107235 CIRBP cold inducible RNA binding protein gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CIRBP mRNA PMID:22747577 12107375 SAR1B secretion associated Ras related GTPase 1B gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20240423 CTD MESH:C526575 masitinib results in decreased expression of SAR1A mRNA PMID:22747577 12108225 VPS29 VPS29 retromer complex component gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS29 mRNA PMID:27255383 12110037 PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of PCK2 protein PMID:19952500 12111199 FADD Fas associated via death domain gene CHEBI:132230 marbofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:C080260 marbofloxacin results in increased expression of FADD mRNA PMID:31005593 12111206 IL31 interleukin 31 gene CHEBI:15864 luteolin multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D047311 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] PMID:33763461 12111206 IL31 interleukin 31 gene CHEBI:69478 cannabidiol multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D002185 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] PMID:33763461 12111640 USO1 USO1 vesicle transport factor gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of USO1 mRNA PMID:27255383 12112287 TRPV1 transient receptor potential cation channel subfamily V member 1 gene CHEBI:3374 capsaicin increases activity EXP E RGD:6480464 20191114 CTD MESH:D002211 Capsaicin results in increased activity of TRPV1 protein PMID:17392452 12112287 TRPV1 transient receptor potential cation channel subfamily V member 1 gene CHEBI:3374 capsaicin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002211 JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] PMID:17392452 12113038 STX4 syntaxin 4 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of STX4 mRNA PMID:27255383 12113445 CPS1 carbamoyl-phosphate synthase 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of CPS1 protein PMID:19952500 12114548 GGT1 gamma-glutamyltransferase 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of GGT1 mRNA PMID:22747577 12114876 SLC10A4 solute carrier family 10 member 4 gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC10A4 mRNA] PMID:25419811 12114876 SLC10A4 solute carrier family 10 member 4 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA] PMID:25419811 12114876 SLC10A4 solute carrier family 10 member 4 gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA] PMID:25419811 12114876 SLC10A4 solute carrier family 10 member 4 gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA] PMID:25419811 12115416 PSMD6 proteasome 26S subunit, non-ATPase 6 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of PSMD6 protein PMID:22747577 12116424 CDKN2A cyclin dependent kinase inhibitor 2A gene CHEBI:64090 tert-butyl hydroperoxide decreases expression EXP E RGD:6480464 20220118 CTD MESH:D020122 tert-Butylhydroperoxide results in decreased expression of CDKN2A protein PMID:14729356 12116574 IL18 interleukin 18 gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of IL18 mRNA PMID:33543323 12116574 IL18 interleukin 18 gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA] PMID:33543323 12117362 TNFSF11 TNF superfamily member 11 gene CHEBI:27881 resveratrol decreases response to substance EXP E RGD:6480464 20191114 CTD MESH:C059514 Resveratrol results in decreased susceptibility to TNFSF11 protein PMID:21239502 12117362 TNFSF11 TNF superfamily member 11 gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C059514 [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased localization of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased localization of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] PMID:21239502 12118927 LIN7C lin-7 homolog C, crumbs cell polarity complex component gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of LIN7C mRNA PMID:22747577 12119872 POMT1 protein O-mannosyltransferase 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of POMT1 mRNA PMID:22747577 12120274 CHMP5 charged multivesicular body protein 5 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of CHMP5 mRNA PMID:27255383 12120555 TRPM8 transient receptor potential cation channel subfamily M member 8 gene CHEBI:22984 calcium atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002118 [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium] PMID:16386244 12120555 TRPM8 transient receptor potential cation channel subfamily M member 8 gene CHEBI:25187 p-menthan-3-ol increases activity EXP E RGD:6480464 20191114 CTD MESH:D008610 Menthol results in increased activity of TRPM8 protein PMID:16386244 12120555 TRPM8 transient receptor potential cation channel subfamily M member 8 gene CHEBI:25187 p-menthan-3-ol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008610 [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium] PMID:16386244 12120555 TRPM8 transient receptor potential cation channel subfamily M member 8 gene CHEBI:29320 calcium(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002118 [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium] PMID:16386244 12120906 TRADD TNFRSF1A associated via death domain gene CHEBI:132230 marbofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:C080260 marbofloxacin results in increased expression of TRADD mRNA PMID:31005593 12120906 TRADD TNFRSF1A associated via death domain gene CHEBI:132230 marbofloxacin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C080260 TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA] PMID:31005593 12120906 TRADD TNFRSF1A associated via death domain gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of TRADD mRNA PMID:24582689 12120906 TRADD TNFRSF1A associated via death domain gene CHEBI:7731 ofloxacin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D015242 TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] PMID:24582689 12121525 TMED1 transmembrane p24 trafficking protein 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TMED1 mRNA PMID:27255383 12121678 SFT2D2 SFT2 domain containing 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of SFT2D2 mRNA PMID:22747577 12122857 PGR progesterone receptor gene CHEBI:17026 progesterone affects binding EXP E RGD:6480464 20191114 CTD MESH:D011374 Progesterone binds to PGR protein PMID:16054490 12122897 TUBG1 tubulin, gamma 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TUBG1 mRNA PMID:27255383 12123938 KNG1 kininogen 1 gene CHEBI:16480 nitric oxide increases activity EXP E RGD:6480464 20191114 CTD MESH:D009569 Nitric Oxide deficiency results in increased activity of KNG1 protein modified form PMID:10805402 12123938 KNG1 kininogen 1 gene CHEBI:25549 nitrites increases chemical synthesis EXP E RGD:6480464 20191114 CTD MESH:D009573 KNG1 protein modified form results in increased chemical synthesis of Nitrites PMID:17644579 12124520 TIMP1 TIMP metallopeptidase inhibitor 1 gene CHEBI:9241 spironolactone increases expression EXP E RGD:6480464 20191114 CTD MESH:D013148 Spironolactone results in increased expression of TIMP1 protein PMID:20082611 12125759 CFTR CF transmembrane conductance regulator gene CHEBI:28088 genistein decreases activity EXP E RGD:6480464 20191114 CTD MESH:D019833 Genistein results in decreased activity of CFTR protein PMID:15496164 12125759 CFTR CF transmembrane conductance regulator gene CHEBI:34457 5-Nitro-2-(3-phenylpropylamino)benzoic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:C058176 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein PMID:15496164 12125759 CFTR CF transmembrane conductance regulator gene CHEBI:34795 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D015056 [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein PMID:15161604 12125759 CFTR CF transmembrane conductance regulator gene CHEBI:5441 glyburide decreases activity EXP E RGD:6480464 20191114 CTD MESH:D005905 Glyburide results in decreased activity of CFTR protein PMID:15496164 12125759 CFTR CF transmembrane conductance regulator gene CHEBI:84612 8-(4-chlorophenylthio)-cAMP multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C015929 [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein PMID:15161604 12127651 GXYLT1 glucoside xylosyltransferase 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of GXYLT1 mRNA PMID:22747577 12130565 PECAM1 platelet and endothelial cell adhesion molecule 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PECAM1 mRNA PMID:22747577 12130594 EBF3 EBF transcription factor 3 gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of EBF3 mRNA] PMID:25419811 12130594 EBF3 EBF transcription factor 3 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA] PMID:25419811 12130594 EBF3 EBF transcription factor 3 gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA] PMID:25419811 12130594 EBF3 EBF transcription factor 3 gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA] PMID:25419811 12131516 ZNF23 zinc finger protein 23 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ZNF23 mRNA PMID:22747577 12132159 ELSPBP1 epididymal sperm binding protein 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ELSPBP1 mRNA PMID:22747577 12132858 TSPAN2 tetraspanin 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TSPAN2 mRNA PMID:22747577 12133381 SMTN smoothelin gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of SMTN mRNA PMID:27255383 12135324 GKN1 gastrokine 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of GKN1 mRNA PMID:22747577 12135641 EIF4A1 eukaryotic translation initiation factor 4A1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of EIF4A1 protein PMID:22747577 12136798 PAH phenylalanine hydroxylase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of PAH protein PMID:19952500 12136864 TUBA4A tubulin alpha 4a gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TUBA4A mRNA PMID:27255383 12136920 ASL argininosuccinate lyase gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of ASL protein PMID:19952500 12136920 ASL argininosuccinate lyase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of ASL protein PMID:19952500 12137992 CYP26A1 cytochrome P450 family 26 subfamily A member 1 gene CHEBI:15367 all-trans-retinoic acid increases degradation EXP E RGD:6480464 20191114 CTD MESH:D014212 CYP26A1 protein results in increased degradation of Tretinoin PMID:17035595 12137992 CYP26A1 cytochrome P450 family 26 subfamily A member 1 gene CHEBI:15367 all-trans-retinoic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014212 CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA] PMID:17035595 12138460 GNAQ G protein subunit alpha q gene CHEBI:61048 ganglioside GM1 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005677 G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein] PMID:21671308 12138460 GNAQ G protein subunit alpha q gene CHEBI:78496 mastoparan multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C037500 G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein PMID:21671308 12138962 ABCG2 ATP binding cassette subfamily G member 2 gene CHEBI:10106 zearalenone increases transport EXP E RGD:6480464 20191114 CTD MESH:D015025 ABCG2 protein results in increased transport of Zearalenone PMID:30576553 12138962 ABCG2 ATP binding cassette subfamily G member 2 gene CHEBI:5831 Hypaconitine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C058309 [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of hypaconitine PMID:23200901 12138962 ABCG2 ATP binding cassette subfamily G member 2 gene CHEBI:6773 Mesaconitine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C019470 [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of mesaconitine PMID:23200901 12140683 MGST2 microsomal glutathione S-transferase 2 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of MGST2 mRNA PMID:19952500 12141041 LYRM1 LYR motif containing 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of LYRM1 mRNA PMID:22747577 12142365 PYCARD PYD and CARD domain containing gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of PYCARD mRNA; ochratoxin A results in increased expression of PYCARD protein PMID:33543323 12142365 PYCARD PYD and CARD domain containing gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein] PMID:33543323 12142742 STOX1 storkhead box 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of STOX1 mRNA PMID:22747577 12142850 CD5L CD5 molecule like gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CD5L mRNA PMID:22747577 12143356 MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of MICAL1 mRNA PMID:27255383 12144117 EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of EDEM2 mRNA PMID:22747577 12144154 SLC9A1 solute carrier family 9 member A1 gene CHEBI:30621 diarsenic trioxide increases expression EXP E RGD:6480464 20191114 CTD MESH:C006632 Arsenic Trioxide results in increased expression of SLC9A1 protein PMID:23236503 12144154 SLC9A1 solute carrier family 9 member A1 gene CHEBI:49900 arsenous acid increases expression EXP E RGD:6480464 20191114 CTD MESH:C032793 Arsenic Trioxide results in increased expression of SLC9A1 protein PMID:23236503 12145444 ACAT2 acetyl-CoA acetyltransferase 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ACAT2 mRNA PMID:22747577 12146852 TTN titin gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TTN mRNA PMID:27255383 12147301 CAT catalase gene CHEBI:36560 zinc oxide decreases activity EXP E RGD:6480464 20191114 CTD MESH:D015034 Zinc Oxide results in decreased activity of CAT protein PMID:28126643 12151468 PDE6H phosphodiesterase 6H gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PDE6H mRNA PMID:22747577 12151708 CYP2D15 cytochrome P450 family 2 subfamily D member 15 gene CHEBI:34593 Bufuralol affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:C010831 CYP2D6 protein affects the metabolism of bufuralol PMID:15801540 12151708 CYP2D15 cytochrome P450 family 2 subfamily D member 15 gene CHEBI:4470 dextromethorphan affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D003915 CYP2D15 affects the metabolism of Dextromethorphan PMID:7786018 12151708 CYP2D15 cytochrome P450 family 2 subfamily D member 15 gene CHEBI:47781 desipramine affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D003891 CYP2D15 affects the metabolism of Desipramine PMID:7786018 12151708 CYP2D15 cytochrome P450 family 2 subfamily D member 15 gene CHEBI:6904 metoprolol affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D008790 CYP2D15 affects the metabolism of Metoprolol PMID:7786018 12152101 SLC22A6 solute carrier family 22 member 6 gene CHEBI:43355 indoxyl sulfate multiple interactions EXP E RGD:6480464 20230404 CTD MESH:D007200 [Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican PMID:36243147 12152101 SLC22A6 solute carrier family 22 member 6 gene CHEBI:6375 lansoprazole multiple interactions EXP E RGD:6480464 20230404 CTD MESH:D064747 [Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican PMID:36243147 12152101 SLC22A6 solute carrier family 22 member 6 gene CHEBI:77260 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions EXP E RGD:6480464 20230404 CTD MESH:D009853 [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican PMID:36243147 12152101 SLC22A6 solute carrier family 22 member 6 gene CHEBI:7772 omeprazole multiple interactions EXP E RGD:6480464 20230404 CTD MESH:D009853 [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican PMID:36243147 12152101 SLC22A6 solute carrier family 22 member 6 gene CHEBI:7915 pantoprazole multiple interactions EXP E RGD:6480464 20230404 CTD MESH:C064276 [Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican PMID:36243147 12152328 PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of PDHA1 mRNA PMID:22747577 12154022 PEX19 peroxisomal biogenesis factor 19 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of PEX19 mRNA PMID:27255383 12154073 LOC479912 glutathione S-transferase Mu 1 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20240423 CTD MESH:D002994 Clofibrate results in decreased expression of GSTM1 mRNA PMID:19952500 12154073 LOC479912 glutathione S-transferase Mu 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20240423 CTD MESH:D010634 Phenobarbital results in decreased expression of GSTM1 mRNA PMID:19952500 12154650 AP3S1 adaptor related protein complex 3 subunit sigma 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of AP3S1 mRNA PMID:27255383 12156386 COPB2 COPI coat complex subunit beta 2 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of COPB2 mRNA PMID:27255383 12157586 ASS1 argininosuccinate synthase 1 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of ASS1 protein PMID:19952500 12157586 ASS1 argininosuccinate synthase 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of ASS1 protein PMID:19952500 12158445 IRX6 iroquois homeobox 6 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of IRX6 protein PMID:22747577 12158997 REN renin gene CHEBI:135026 xibenolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C006027 xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] PMID:6103674 12158997 REN renin gene CHEBI:145568 cilazapril monohydrate increases activity EXP E RGD:6480464 20200107 CTD MESH:D017315 Cilazapril results in increased activity of REN protein PMID:2419701 12158997 REN renin gene CHEBI:15551 prostaglandin E2 increases expression EXP E RGD:6480464 20191114 CTD MESH:D015232 Dinoprostone results in increased expression of REN protein PMID:495730 12158997 REN renin gene CHEBI:18357 (R)-noradrenaline increases activity EXP E RGD:6480464 20191114 CTD MESH:D009638 Norepinephrine results in increased activity of REN protein PMID:8952593 12158997 REN renin gene CHEBI:2668 amlodipine increases expression EXP E RGD:6480464 20191114 CTD MESH:D017311 Amlodipine results in increased expression of REN protein PMID:10218729 12158997 REN renin gene CHEBI:2682 amphotericin B decreases secretion EXP E RGD:6480464 20191114 CTD MESH:D000666 Amphotericin B results in decreased secretion of REN protein PMID:7391978 12158997 REN renin gene CHEBI:28787 nitroglycerin decreases activity EXP E RGD:6480464 20191114 CTD MESH:D005996 Nitroglycerin results in decreased activity of REN protein PMID:8640982 12158997 REN renin gene CHEBI:2904 atenolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D001262 Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] PMID:6103674 12158997 REN renin gene CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor increases activity EXP E RGD:6480464 20191114 CTD MESH:D000806 Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein PMID:6257882 12158997 REN renin gene CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor increases secretion EXP E RGD:6480464 20191114 CTD MESH:D000806 Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein PMID:6185789 12158997 REN renin gene CHEBI:3757 clonidine (imino form) decreases activity EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in decreased activity of REN protein PMID:6991409 12158997 REN renin gene CHEBI:3757 clonidine (imino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in decreased secretion of and results in decreased activity of REN protein PMID:6248808 12158997 REN renin gene CHEBI:46631 clonidine decreases activity EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in decreased activity of REN protein PMID:6991409 12158997 REN renin gene CHEBI:46631 clonidine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in decreased secretion of and results in decreased activity of REN protein PMID:6248808 12158997 REN renin gene CHEBI:46632 clonidine (amino form) decreases activity EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in decreased activity of REN protein PMID:6991409 12158997 REN renin gene CHEBI:46632 clonidine (amino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in decreased secretion of and results in decreased activity of REN protein PMID:6248808 12158997 REN renin gene CHEBI:472805 ouabain decreases secretion EXP E RGD:6480464 20191114 CTD MESH:D010042 Ouabain results in decreased secretion of REN protein PMID:6093556 12158997 REN renin gene CHEBI:472805 ouabain multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D010042 Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein] PMID:6093556 12158997 REN renin gene CHEBI:4784 enalapril increases activity EXP E RGD:6480464 20191114 CTD MESH:D004656 Enalapril results in increased activity of REN protein PMID:12019275 12158997 REN renin gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 [Enalapril co-treated with FR 173657] results in increased activity of REN protein PMID:12019275 12158997 REN renin gene CHEBI:64317 isoprenaline increases activity EXP E RGD:6480464 20191114 CTD MESH:D007545 Isoproterenol results in increased activity of REN protein PMID:6103674 12158997 REN renin gene CHEBI:64317 isoprenaline multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007545 Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] PMID:6103674 12158997 REN renin gene CHEBI:6541 losartan increases expression EXP E RGD:6480464 20191114 CTD MESH:D019808 Losartan results in increased expression of REN protein PMID:10483973 12158997 REN renin gene CHEBI:74125 losartan carboxylic acid increases expression EXP E RGD:6480464 20191114 CTD MESH:C066026 losartan carboxylic acid results in increased expression of REN protein PMID:10483973 12158997 REN renin gene CHEBI:7596 nitroprusside increases activity EXP E RGD:6480464 20191114 CTD MESH:D009599 Nitroprusside results in increased activity of REN protein PMID:2434793|PMID:6399253 12158997 REN renin gene CHEBI:7983 pentobarbital increases activity EXP E RGD:6480464 20191114 CTD MESH:D010424 Pentobarbital results in increased activity of REN protein PMID:6348358 12158997 REN renin gene CHEBI:8093 phenylephrine increases secretion EXP E RGD:6480464 20191114 CTD MESH:D010656 Phenylephrine results in increased secretion of REN protein PMID:6347479 12158997 REN renin gene CHEBI:8214 pindolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D010869 Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] PMID:6103674 12158997 REN renin gene CHEBI:8499 propranolol decreases activity EXP E RGD:6480464 20191114 CTD MESH:D011433 Propranolol results in decreased activity of REN protein PMID:2566282 12158997 REN renin gene CHEBI:8499 propranolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011433 Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] PMID:6103674 12158997 REN renin gene CHEBI:8862 Rilmenidine decreases activity EXP E RGD:6480464 20191114 CTD MESH:C032302 Rilmenidine results in decreased activity of REN protein PMID:2866274 12160227 RPS6KB1 ribosomal protein S6 kinase B1 gene CHEBI:9753 troglitazone multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C057693 Troglitazone results in decreased activity of and results in decreased phosphorylation of RPS6KB1 protein PMID:16825603 12162018 NOS2 nitric oxide synthase 2 gene CHEBI:17883 hydrogen chloride increases activity EXP E RGD:6480464 20191114 CTD MESH:D006851 Hydrochloric Acid results in increased activity of NOS2 protein PMID:14621274 12162819 VPS16 VPS16 core subunit of CORVET and HOPS complexes gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS16 mRNA PMID:27255383 12164689 NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of NDUFS1 mRNA PMID:22747577 12164984 SPP1 secreted phosphoprotein 1 gene CHEBI:17833 gentamycin increases expression EXP E RGD:6480464 20210608 CTD MESH:D005839 Gentamicins results in increased expression of SPP1 protein PMID:33290828 12166457 FTCD formimidoyltransferase cyclodeaminase gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of FTCD protein PMID:19952500 12167375 ALAS2 5'-aminolevulinate synthase 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ALAS2 mRNA PMID:22747577 12167898 SELENBP1 selenium binding protein 1 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of SELENBP1 protein PMID:19952500 12167898 SELENBP1 selenium binding protein 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of SELENBP1 protein PMID:22747577 12167898 SELENBP1 selenium binding protein 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of SELENBP1 protein PMID:19952500 12169167 DDIT3 DNA damage inducible transcript 3 gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of DDIT3 mRNA PMID:24582689 12169872 CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 gene CHEBI:6931 midazolam affects metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D008874 CYP3A4 protein affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam PMID:15801540 12169872 CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of CYP3A4 mRNA PMID:19952500 12169889 CPNE6 copine 6 gene CHEBI:15342 acenaphthoquinone increases reduction EXP E RGD:6480464 20191114 CTD MESH:C023722 DHRS4 protein results in increased reduction of acenaphthenequinone PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:16243 quercetin decreases activity EXP E RGD:6480464 20191114 CTD MESH:D011794 Quercetin results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:16325 lithocholic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:D008095 Lithocholic Acid results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:17639 3-oxo-5beta-cholanic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:C046230 3-oxocholan-24-oic acid results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:18280 phenylglyoxylic acid increases reduction EXP E RGD:6480464 20191114 CTD MESH:C012482 DHRS4 protein results in increased reduction of phenylglyoxylic acid PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:27539 isatin increases reduction EXP E RGD:6480464 20191114 CTD MESH:D007510 DHRS4 protein results in increased reduction of Isatin PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:28088 genistein decreases activity EXP E RGD:6480464 20191114 CTD MESH:D019833 Genistein results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:28499 kaempferol decreases activity EXP E RGD:6480464 20191114 CTD MESH:C006552 kaempferol results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:28869 menadione increases reduction EXP E RGD:6480464 20191114 CTD MESH:D024483 DHRS4 protein results in increased reduction of Vitamin K 3 PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:28875 tetradecanoic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:D019814 Myristic Acid results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:34166 16-Ketoestrone increases reduction EXP E RGD:6480464 20191114 CTD MESH:C002591 DHRS4 protein results in increased reduction of 16-ketoestrone PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:36237 cholanic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:C007036 cholanic acid results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:36812 valerophenone increases reduction EXP E RGD:6480464 20191114 CTD MESH:C547345 DHRS4 protein results in increased reduction of valerophenone PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:37454 9,10-phenanthroquinone increases reduction EXP E RGD:6480464 20191114 CTD MESH:C005399 DHRS4 protein results in increased reduction of 9,10-phenanthrenequinone PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:39867 valproic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:D014635 Valproic Acid results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:42638 flufenamic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:D005439 Flufenamic Acid results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:52774 pentane-2,3-dione increases reduction EXP E RGD:6480464 20191114 CTD MESH:C013186 DHRS4 protein results in increased reduction of 2,3-pentanedione PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of DHRS4 mRNA PMID:22747577 12169889 CPNE6 copine 6 gene CHEBI:63836 bromosulfophthalein decreases activity EXP E RGD:6480464 20191114 CTD MESH:D013448 Sulfobromophthalein results in decreased activity of DHRS4 protein PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:78273 9-cis-retinal increases reduction EXP E RGD:6480464 20191114 CTD MESH:C031390 DHRS4 protein results in increased reduction of 9-cis-retinal PMID:17827741 12169889 CPNE6 copine 6 gene CHEBI:87583 hexane-2,3-dione increases reduction EXP E RGD:6480464 20191114 CTD MESH:C043231 DHRS4 protein results in increased reduction of 2,3-hexanedione PMID:17827741 12170359 CNR2 cannabinoid receptor 2 gene CHEBI:135574 nabilone affects binding EXP E RGD:6480464 20191114 CTD MESH:C011941 nabilone binds to CNR2 protein PMID:21871882 12170359 CNR2 cannabinoid receptor 2 gene CHEBI:146245 SR 144528 multiple interactions EXP E RGD:6480464 20200407 CTD MESH:C110630 SR 144528 binds to and results in decreased activity of CNR2 protein PMID:21871882 12170359 CNR2 cannabinoid receptor 2 gene CHEBI:73295 WIN 55212-2 affects binding EXP E RGD:6480464 20191114 CTD MESH:C070417 (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone binds to CNR2 protein PMID:21871882 12171830 PPA1 inorganic pyrophosphatase 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of PPA1 protein PMID:22747577 12172571 PRKACB protein kinase cAMP-activated catalytic subunit beta gene CHEBI:2682 amphotericin B increases expression EXP E RGD:6480464 20240423 CTD MESH:D000666 Amphotericin B results in increased expression of PRKACG protein PMID:24105867 12172571 PRKACB protein kinase cAMP-activated catalytic subunit beta gene CHEBI:2682 amphotericin B multiple interactions EXP E RGD:6480464 20240423 CTD MESH:D000666 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] PMID:24105867 12172571 PRKACB protein kinase cAMP-activated catalytic subunit beta gene CHEBI:47495 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP E RGD:6480464 20240423 CTD MESH:C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] PMID:24105867 12173937 GSTO1 glutathione S-transferase omega 1 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of GSTO1 mRNA PMID:19952500 12173937 GSTO1 glutathione S-transferase omega 1 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of GSTO1 mRNA PMID:19952500 12175766 NTRK1 neurotrophic receptor tyrosine kinase 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of NTRK1 mRNA PMID:22747577 12176018 MYOZ1 myozenin 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of MYOZ1 mRNA PMID:22747577 12176711 CLU clusterin gene CHEBI:17833 gentamycin increases expression EXP E RGD:6480464 20191114 CTD MESH:D005839 Gentamicins results in increased expression of CLU mRNA; Gentamicins results in increased expression of CLU protein PMID:25034533|PMID:33290828 12178044 AHR aryl hydrocarbon receptor gene CHEBI:28119 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013749 [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein PMID:24389113 12178044 AHR aryl hydrocarbon receptor gene CHEBI:28909 iprodione multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C033148 [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein PMID:24389113 12178044 AHR aryl hydrocarbon receptor gene CHEBI:32114 salicylamide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C031060 [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin PMID:24389113 12178044 AHR aryl hydrocarbon receptor gene CHEBI:63933 Aroclor 1254 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D020111 [Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein PMID:24389113 12178044 AHR aryl hydrocarbon receptor gene CHEBI:8434 prochloraz multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C045362 [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz PMID:24389113 12180515 CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of CYP2A13 mRNA PMID:19952500 12180515 CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of CYP2A13 mRNA PMID:19952500 12181438 ASCC1 activating signal cointegrator 1 complex subunit 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ASCC1 mRNA PMID:22747577 12182321 CLDN1 claudin 1 gene CHEBI:15367 all-trans-retinoic acid increases expression EXP E RGD:6480464 20191114 CTD MESH:D014212 Tretinoin results in increased expression of CLDN1 mRNA; Tretinoin results in increased expression of CLDN1 protein PMID:17035595 12182321 CLDN1 claudin 1 gene CHEBI:15367 all-trans-retinoic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014212 CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA] PMID:17035595 12182644 LOC475707 GPN-loop GTPase 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of GPN1 mRNA PMID:22747577 12184043 CYP2C41 cytochrome P450 2C41 gene CHEBI:17578 toluene affects metabolic processing EXP E RGD:6480464 20231128 CTD MESH:D014050 CYP2C11 protein affects the metabolism of Toluene PMID:8592870 12184043 CYP2C41 cytochrome P450 2C41 gene CHEBI:17847 p-cresol affects metabolic processing EXP E RGD:6480464 20231128 CTD MESH:C032538 CYP2C11 protein affects the metabolism of 4-cresol PMID:8592870 12184043 CYP2C41 cytochrome P450 2C41 gene CHEBI:17987 benzyl alcohol affects metabolic processing EXP E RGD:6480464 20231128 CTD MESH:D019905 CYP2C11 protein affects the metabolism of Benzyl Alcohol PMID:8592870 12184043 CYP2C41 cytochrome P450 2C41 gene CHEBI:47381 diclofenac affects metabolic processing EXP E RGD:6480464 20220412 CTD MESH:D004008 CYP2C9 protein affects the metabolism of Diclofenac PMID:15801540 12184043 CYP2C41 cytochrome P450 2C41 gene CHEBI:47381 diclofenac increases hydroxylation EXP E RGD:6480464 20240423 CTD MESH:D004008 CYP2C19 protein results in increased hydroxylation of Diclofenac PMID:15677349 12184043 CYP2C41 cytochrome P450 2C41 gene CHEBI:49575 diazepam affects metabolic processing EXP E RGD:6480464 20240423 CTD MESH:D003975 CYP2C19 protein affects the metabolism of Diazepam PMID:15801540 12184558 ACSM3 acyl-CoA synthetase medium chain family member 3 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ACSM3 mRNA PMID:22747577 12185148 SEC24D SEC24 homolog D, COPII coat complex component gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SEC24D mRNA PMID:27255383 12185184 ATP6V0D1 ATPase H+ transporting V0 subunit d1 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of ATP6V0D1 protein PMID:32991862 12185421 ACHE acetylcholinesterase gene CHEBI:136185 VX nerve agent decreases activity EXP E RGD:6480464 20191114 CTD MESH:C009680 VX results in decreased activity of ACHE protein PMID:16915560 12185421 ACHE acetylcholinesterase gene CHEBI:136185 VX nerve agent multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C009680 [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] PMID:16915560 12185421 ACHE acetylcholinesterase gene CHEBI:16684 atropine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D001285 [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] PMID:16915560 12185421 ACHE acetylcholinesterase gene CHEBI:34690 dichlorvos decreases activity EXP E RGD:6480464 20191114 CTD MESH:D004006 Dichlorvos results in decreased activity of ACHE protein PMID:3627083|PMID:89824 12185421 ACHE acetylcholinesterase gene CHEBI:75701 sarin decreases activity EXP E RGD:6480464 20191114 CTD MESH:D012524 Sarin results in decreased activity of ACHE protein PMID:16915560 12185421 ACHE acetylcholinesterase gene CHEBI:75701 sarin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012524 [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein] PMID:16915560 12185421 ACHE acetylcholinesterase gene CHEBI:78734 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D001285 [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] PMID:16915560 12185421 ACHE acetylcholinesterase gene CHEBI:9195 Soman decreases activity EXP E RGD:6480464 20191114 CTD MESH:D012999 Soman results in decreased activity of ACHE protein PMID:16915560 12185421 ACHE acetylcholinesterase gene CHEBI:9195 Soman multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012999 [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein] PMID:16915560 12185534 CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20240423 CTD MESH:D002994 Clofibrate results in increased expression of CYP4A11 mRNA PMID:19952500 12185534 CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20240423 CTD MESH:D010634 Phenobarbital results in decreased expression of CYP4A11 mRNA PMID:19952500 12185593 TEAD4 TEA domain transcription factor 4 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TEAD4 mRNA PMID:22747577 12187213 SLC2A9 solute carrier family 2 member 9 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases transport EXP E RGD:6480464 20191114 CTD MESH:D014527 SLC2A9 protein results in increased transport of Uric Acid PMID:18989453 12187275 CASK calcium/calmodulin dependent serine protein kinase gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of CASK mRNA PMID:27255383 12187382 MDH2 malate dehydrogenase 2 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of MDH2 protein PMID:32991862 12187832 ACE angiotensin I converting enzyme gene CHEBI:177391 Ceronapril decreases activity EXP E RGD:6480464 20210907 CTD MESH:C054518 ceronapril results in decreased activity of ACE protein PMID:1812274 12188501 NOX4 NADPH oxidase 4 gene CHEBI:32020 pitavastatin decreases expression EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in decreased expression of NOX4 mRNA PMID:15502390 12188501 NOX4 NADPH oxidase 4 gene CHEBI:71260 pitavastatin(1-) decreases expression EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in decreased expression of NOX4 mRNA PMID:15502390 12188532 ADRA2A adrenoceptor alpha 2A gene CHEBI:3757 clonidine (imino form) increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D003000 ADRA2A protein results in increased susceptibility to Clonidine PMID:16814767 12188532 ADRA2A adrenoceptor alpha 2A gene CHEBI:3757 clonidine (imino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine binds to and results in increased activity of ADRA2A protein PMID:16814767 12188532 ADRA2A adrenoceptor alpha 2A gene CHEBI:46631 clonidine increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D003000 ADRA2A protein results in increased susceptibility to Clonidine PMID:16814767 12188532 ADRA2A adrenoceptor alpha 2A gene CHEBI:46631 clonidine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine binds to and results in increased activity of ADRA2A protein PMID:16814767 12188532 ADRA2A adrenoceptor alpha 2A gene CHEBI:46632 clonidine (amino form) increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D003000 ADRA2A protein results in increased susceptibility to Clonidine PMID:16814767 12188532 ADRA2A adrenoceptor alpha 2A gene CHEBI:46632 clonidine (amino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine binds to and results in increased activity of ADRA2A protein PMID:16814767 12188915 ACTR2 actin related protein 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ACTR2 protein PMID:22747577 12189900 PDIA3 protein disulfide isomerase family A member 3 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PDIA3 protein PMID:22747577 12189900 PDIA3 protein disulfide isomerase family A member 3 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of PDIA3 protein PMID:19952500 12190112 KCNJ2 potassium inwardly rectifying channel subfamily J member 2 gene CHEBI:17347 testosterone increases expression EXP E RGD:6480464 20191114 CTD MESH:D013739 Testosterone results in increased expression of KCNJ2 protein PMID:17054656 12190768 RAB31 RAB31, member RAS oncogene family gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of RAB31 mRNA PMID:27255383 12190790 WT1 WT1 transcription factor gene CHEBI:16480 nitric oxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009569 [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA PMID:21443142 12190790 WT1 WT1 transcription factor gene CHEBI:7596 nitroprusside multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009599 [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA PMID:21443142 12192059 IL1B interleukin 1 beta gene CHEBI:16412 lipopolysaccharide increases expression EXP E RGD:6480464 20220405 CTD MESH:D008070 Lipopolysaccharides results in increased expression of IL1B mRNA PMID:32899721 12192059 IL1B interleukin 1 beta gene CHEBI:16412 lipopolysaccharide multiple interactions EXP E RGD:6480464 20220405 CTD MESH:D008070 arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] PMID:32899721 12192059 IL1B interleukin 1 beta gene CHEBI:29866 arsenite(3-) multiple interactions EXP E RGD:6480464 20220405 CTD MESH:C015001 arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] PMID:32899721 12192059 IL1B interleukin 1 beta gene CHEBI:44445 nimesulide decreases expression EXP E RGD:6480464 20191114 CTD MESH:C012655 nimesulide results in decreased expression of IL1B mRNA PMID:19638440 12192059 IL1B interleukin 1 beta gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B protein PMID:33543323 12192059 IL1B interleukin 1 beta gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein] PMID:33543323 12192158 VPS33B VPS33B late endosome and lysosome associated gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS33B mRNA PMID:27255383 12192371 ALPI alkaline phosphatase, intestinal gene CHEBI:17263 estrone increases chemical synthesis EXP E RGD:6480464 20191114 CTD MESH:D004970 ALPI protein results in increased chemical synthesis of Estrone PMID:1495895 12192371 ALPI alkaline phosphatase, intestinal gene CHEBI:17440 4-nitrophenyl phosphate increases chemical synthesis EXP E RGD:6480464 20191114 CTD MESH:C008644 ALPI protein results in increased chemical synthesis of nitrophenylphosphate PMID:1495895 12192371 ALPI alkaline phosphatase, intestinal gene CHEBI:27632 acetophenone increases chemical synthesis EXP E RGD:6480464 20191114 CTD MESH:C038699 ALPI protein results in increased chemical synthesis of acetophenone PMID:1495895 12194335 MGMT O-6-methylguanine-DNA methyltransferase gene CHEBI:3423 carmustine decreases response to substance EXP E RGD:6480464 20191114 CTD MESH:D002330 MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine PMID:15053863 12194335 MGMT O-6-methylguanine-DNA methyltransferase gene CHEBI:3423 carmustine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002330 MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine] PMID:14617759 12195592 SAE1 SUMO1 activating enzyme subunit 1 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of SAE1 protein PMID:32991862 12195612 EBPL EBP like gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of EBPL mRNA PMID:22747577 12196334 STX16 syntaxin 16 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of STX16 mRNA PMID:22747577 12197733 ARF4 ADP ribosylation factor 4 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of ARF4 mRNA PMID:27255383 12197785 RYR2 ryanodine receptor 2 gene CHEBI:3441 carvedilol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C043211 Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein PMID:17448375 12198974 NAPG NSF attachment protein gamma gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of NAPG mRNA PMID:22747577 12199021 APP amyloid beta precursor protein gene CHEBI:28694 copper atom increases expression EXP E RGD:6480464 20191114 CTD MESH:D003300 Copper results in increased expression of APP protein PMID:16886094 12199021 APP amyloid beta precursor protein gene CHEBI:30052 copper(0) increases expression EXP E RGD:6480464 20191114 CTD MESH:D003300 Copper results in increased expression of APP protein PMID:16886094 12199089 LOC474850 heat shock 70 kDa protein 1-like gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of HSPA1L mRNA PMID:22747577 12199883 PSMD9 proteasome 26S subunit, non-ATPase 9 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of PSMD9 mRNA PMID:22747577 12201020 CPNE1 copine 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CPNE1 mRNA PMID:22747577 12201171 FGFR2 fibroblast growth factor receptor 2 gene CHEBI:17883 hydrogen chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D006851 Hydrochloric Acid results in increased expression of FGFR2 mRNA PMID:15883737 12203515 TMEM108 transmembrane protein 108 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TMEM108 mRNA PMID:22747577 12203958 MGST1 microsomal glutathione S-transferase 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of MGST1 mRNA PMID:19952500 12203958 MGST1 microsomal glutathione S-transferase 1 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of MGST1 mRNA PMID:19952500 12204155 SPTBN1 spectrin beta, non-erythrocytic 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SPTBN1 mRNA PMID:27255383 12205516 ITGA6 integrin subunit alpha 6 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ITGA6 mRNA PMID:22747577 12205685 ATP5F1B ATP synthase F1 subunit beta gene CHEBI:17883 hydrogen chloride decreases expression EXP E RGD:6480464 20191114 CTD MESH:D006851 Hydrochloric Acid results in decreased expression of ATP5F1B mRNA PMID:15883737 12205685 ATP5F1B ATP synthase F1 subunit beta gene CHEBI:17883 hydrogen chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006851 [Hydrochloric Acid co-treated with Bile Acids and Salts] results in decreased expression of ATP5F1B mRNA PMID:15883737 12206121 PLCG1 phospholipase C gamma 1 gene CHEBI:60427 dioleoyl phosphatidic acid increases activity EXP E RGD:6480464 20191114 CTD MESH:C037657 dioleoylphosphatidic acid results in increased activity of PLCG1 protein PMID:2001791 12206121 PLCG1 phospholipase C gamma 1 gene CHEBI:62085 dimyristoyl phosphatidic acid increases activity EXP E RGD:6480464 20191114 CTD MESH:C025602 dimyristoylphosphatidic acid results in increased activity of PLCG1 protein PMID:2001791 12206121 PLCG1 phospholipase C gamma 1 gene CHEBI:72999 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine decreases activity EXP E RGD:6480464 20191114 CTD MESH:D015060 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein PMID:2001791 12206121 PLCG1 phospholipase C gamma 1 gene CHEBI:72999 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D015060 dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein] PMID:2001791 12206121 PLCG1 phospholipase C gamma 1 gene CHEBI:78105 dihexadecanoyl phosphatidic acid increases activity EXP E RGD:6480464 20191114 CTD MESH:C031599 dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein PMID:2001791 12206121 PLCG1 phospholipase C gamma 1 gene CHEBI:78105 dihexadecanoyl phosphatidic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C031599 dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein] PMID:2001791 12206121 PLCG1 phospholipase C gamma 1 gene CHEBI:84165 1-stearoyl-2-arachidonoylphosphatidic acid increases activity EXP E RGD:6480464 20191114 CTD MESH:C060203 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein PMID:2001791 12206702 ANP32E acidic nuclear phosphoprotein 32 family member E gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ANP32E mRNA PMID:22747577 12206766 TNNT2 troponin T2, cardiac type gene CHEBI:28748 doxorubicin affects expression EXP E RGD:6480464 20191114 CTD MESH:D004317 Doxorubicin affects the expression of TNNT2 protein PMID:12322705 12206884 COPB1 COPI coat complex subunit beta 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of COPB1 mRNA PMID:27255383 12206910 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of DNAJC3 protein PMID:32991862 12207057 HIF1A hypoxia inducible factor 1 subunit alpha gene CHEBI:34159 15-deoxy-Delta(12,14)-prostaglandin J2 increases expression EXP E RGD:6480464 20191114 CTD MESH:C097240 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein PMID:17658243 12207336 SCD stearoyl-CoA desaturase gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of SCD mRNA PMID:22747577 12207969 ADPRH ADP-ribosylarginine hydrolase gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ADPRH mRNA PMID:22747577 12208058 GSTK1 glutathione S-transferase kappa 1 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of GSTK1 mRNA PMID:19952500 12208319 LOC486353 SEC14-like protein 4 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of SEC14L4 protein PMID:19952500 12209006 IMMT inner membrane mitochondrial protein gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of IMMT protein PMID:32991862 12209509 GPT glutamic--pyruvic transaminase gene CHEBI:9728 trimethaphan increases expression EXP E RGD:6480464 20191114 CTD MESH:D014294 Trimethaphan results in increased expression of GPT protein PMID:6848019 12209713 NSG1 neuronal vesicle trafficking associated 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of NSG1 mRNA PMID:22747577 12210134 SCN10A sodium voltage-gated channel alpha subunit 10 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SCN10A mRNA PMID:27255383 12210611 LCN2 lipocalin 2 gene CHEBI:17833 gentamycin increases expression EXP E RGD:6480464 20191114 CTD MESH:D005839 Gentamicins results in increased expression of LCN2 mRNA; Gentamicins results in increased expression of LCN2 protein PMID:25034533|PMID:33290828 12212542 TSHB thyroid stimulating hormone subunit beta gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TSHB mRNA PMID:22747577 12212878 VTI1B vesicle transport through interaction with t-SNAREs 1B gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VTI1B mRNA PMID:27255383 12213188 GABRQ gamma-aminobutyric acid type A receptor subunit theta gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GABRQ mRNA] PMID:25419811 12213188 GABRQ gamma-aminobutyric acid type A receptor subunit theta gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA] PMID:25419811 12213188 GABRQ gamma-aminobutyric acid type A receptor subunit theta gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA] PMID:25419811 12213188 GABRQ gamma-aminobutyric acid type A receptor subunit theta gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA] PMID:25419811 12213368 CDKN1A cyclin dependent kinase inhibitor 1A gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CDKN1A mRNA PMID:22747577 12213379 AGA aspartylglucosaminidase gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of AGA mRNA PMID:22747577 12213672 CLTCL1 clathrin heavy chain like 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of CLTCL1 mRNA PMID:27255383 12213926 SIRT1 sirtuin 1 gene CHEBI:17154 nicotinamide decreases expression EXP E RGD:6480464 20191114 CTD MESH:D009536 Niacinamide results in decreased expression of SIRT1 protein PMID:22539994 12213926 SIRT1 sirtuin 1 gene CHEBI:17154 nicotinamide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009536 Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein] PMID:22539994 12213926 SIRT1 sirtuin 1 gene CHEBI:27881 resveratrol increases activity EXP E RGD:6480464 20191114 CTD MESH:C059514 Resveratrol results in increased activity of SIRT1 protein PMID:22539994 12213926 SIRT1 sirtuin 1 gene CHEBI:27881 resveratrol increases expression EXP E RGD:6480464 20191114 CTD MESH:C059514 Resveratrol results in increased expression of SIRT1 protein PMID:21239502|PMID:22539994 12213926 SIRT1 sirtuin 1 gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C059514 [[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein; [Resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of SIRT1 protein]; Resveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein]; SIRT1 protein affects the reaction [Resveratrol results in decreased acetylation of RUNX2 protein] PMID:21239502|PMID:22539994 12215478 SELP selectin P gene CHEBI:31530 edaravone decreases expression EXP E RGD:6480464 20191114 CTD MESH:C005435 Edaravone results in decreased expression of SELP protein PMID:16041266 12215478 SELP selectin P gene CHEBI:9574 Thrombin increases expression EXP E RGD:6480464 20191114 CTD MESH:D013917 Thrombin results in increased expression of SELP PMID:21034320 12215829 GPAA1 glycosylphosphatidylinositol anchor attachment 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of GPAA1 mRNA PMID:27255383 12221388 MOB1B MOB kinase activator 1B gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of MOB1B mRNA PMID:22747577 12221655 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of YWHAZ protein PMID:22747577 12224500 CYP2C18 cytochrome P450 2C21 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of CYP2C18 mRNA PMID:19952500 12224854 GSR glutathione-disulfide reductase gene CHEBI:29678 sodium arsenite decreases activity EXP E RGD:6480464 20191114 CTD MESH:C017947 sodium arsenite results in decreased activity of GSR protein PMID:18163546 12224854 GSR glutathione-disulfide reductase gene CHEBI:29678 sodium arsenite multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C017947 [monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] PMID:18163546 12224854 GSR glutathione-disulfide reductase gene CHEBI:63623 succimer multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004113 [monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] PMID:18163546 12225383 RGS13 regulator of G protein signaling 13 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of RGS13 mRNA PMID:22747577 12225830 DAO D-amino acid oxidase gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of DAO mRNA] PMID:25419811 12225830 DAO D-amino acid oxidase gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA] PMID:25419811 12225830 DAO D-amino acid oxidase gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA] PMID:25419811 12225830 DAO D-amino acid oxidase gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA] PMID:25419811 12226040 VPS54 VPS54 subunit of GARP complex gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of VPS54 mRNA PMID:27255383 12226319 SYTL1 synaptotagmin like 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SYTL1 mRNA PMID:27255383 12227151 KIF5B kinesin family member 5B gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of KIF5B mRNA PMID:27255383 12228288 MAPK14 mitogen-activated protein kinase 14 gene CHEBI:15355 acetylcholine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000109 Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein PMID:9688607 12228338 CCT2 chaperonin containing TCP1 subunit 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of CCT2 protein PMID:22747577 12228377 UROC1 urocanate hydratase 1 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of UROC1 protein PMID:19952500 12228377 UROC1 urocanate hydratase 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of UROC1 protein PMID:19952500 12228928 SCAMP3 secretory carrier membrane protein 3 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of SCAMP3 mRNA PMID:27255383 12230130 RAB11A RAB11A, member RAS oncogene family gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of RAB11A protein PMID:32991862 12230450 KRT1 keratin 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of KRT1 protein PMID:19952500 12230481 PSMB9 proteasome 20S subunit beta 9 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PSMB9 mRNA PMID:22747577 12234055 NAB1 NGFI-A binding protein 1 gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein PMID:18820026 12234055 NAB1 NGFI-A binding protein 1 gene CHEBI:6904 metoprolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008790 [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein PMID:18820026 12234055 NAB1 NGFI-A binding protein 1 gene CHEBI:87681 ranolazine affects expression EXP E RGD:6480464 20191114 CTD MESH:D000069458 Ranolazine affects the expression of NAB1 protein PMID:18820026 12234055 NAB1 NGFI-A binding protein 1 gene CHEBI:87681 ranolazine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000069458 [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein PMID:18820026 12235605 SLC22A2 solute carrier family 22 member 2 gene CHEBI:3699 cimetidine decreases activity EXP E RGD:6480464 20230801 CTD MESH:D002927 Cimetidine results in decreased activity of SLC22A2 protein PMID:36669674 12235605 SLC22A2 solute carrier family 22 member 2 gene CHEBI:81781 tebuconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087114 tebuconazole results in decreased activity of SLC22A2 protein PMID:36669674 12235605 SLC22A2 solute carrier family 22 member 2 gene CHEBI:81970 penconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087058 penconazole results in decreased activity of SLC22A2 protein PMID:36669674 12235618 IL4 interleukin 4 gene CHEBI:15864 luteolin multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D047311 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] PMID:33763461 12235618 IL4 interleukin 4 gene CHEBI:69478 cannabidiol multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D002185 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] PMID:33763461 12235905 SOD2 superoxide dismutase 2 gene CHEBI:16199 urea increases expression EXP E RGD:6480464 20191114 CTD MESH:D014508 Urea results in increased expression of SOD2 protein PMID:22718889 12235905 SOD2 superoxide dismutase 2 gene CHEBI:16240 hydrogen peroxide decreases activity EXP E RGD:6480464 20191114 CTD MESH:D006861 Hydrogen Peroxide results in decreased activity of SOD2 protein PMID:16682413 12235905 SOD2 superoxide dismutase 2 gene CHEBI:16240 hydrogen peroxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006861 Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] PMID:16682413 12235905 SOD2 superoxide dismutase 2 gene CHEBI:16330 17beta-hydroxy-5alpha-androstan-3-one multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013196 Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] PMID:16682413 12235905 SOD2 superoxide dismutase 2 gene CHEBI:26710 sodium chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased expression of SOD2 protein PMID:22718889 12239792 CYP2B6 cytochrome P450 2B11 gene CHEBI:10033 warfarin increases hydroxylation EXP E RGD:6480464 20191114 CTD MESH:D014859 CYP2B6 protein results in increased hydroxylation of Warfarin PMID:12637241 12239792 CYP2B6 cytochrome P450 2B11 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of CYP2B6 mRNA PMID:19952500 12239792 CYP2B6 cytochrome P450 2B11 gene CHEBI:4027 cyclophosphamide increases hydroxylation EXP E RGD:6480464 20191114 CTD MESH:D003520 CYP2B6 protein results in increased hydroxylation of Cyclophosphamide PMID:16546968 12239792 CYP2B6 cytochrome P450 2B11 gene CHEBI:4470 dextromethorphan increases metabolic processing EXP E RGD:6480464 20191114 CTD MESH:D003915 CYP2B6 protein results in increased metabolism of Dextromethorphan PMID:12637241 12239792 CYP2B6 cytochrome P450 2B11 gene CHEBI:6757 mephenytoin increases hydroxylation EXP E RGD:6480464 20191114 CTD MESH:D008617 CYP2B6 protein results in increased hydroxylation of Mephenytoin PMID:12637241 12239792 CYP2B6 cytochrome P450 2B11 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of CYP2B6 protein PMID:19952500 12239972 ABLIM1 actin binding LIM protein 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ABLIM1 mRNA PMID:22747577 12240290 P2RY2 purinergic receptor P2Y2 gene CHEBI:15713 UTP increases activity EXP E RGD:6480464 20191114 CTD MESH:D014544 Uridine Triphosphate results in increased activity of P2RY2 protein PMID:10604969 12240290 P2RY2 purinergic receptor P2Y2 gene CHEBI:15713 UTP multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014544 [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] PMID:10604969 12240290 P2RY2 purinergic receptor P2Y2 gene CHEBI:15843 arachidonic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D016718 [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid] PMID:10604969 12240290 P2RY2 purinergic receptor P2Y2 gene CHEBI:17489 3',5'-cyclic AMP multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000242 [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] PMID:10604969 12240290 P2RY2 purinergic receptor P2Y2 gene CHEBI:34941 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C077792 pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] PMID:10604969 12240550 SNX24 sorting nexin 24 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SNX24 mRNA PMID:27255383 12242625 KCNJ6 potassium inwardly rectifying channel subfamily J member 6 gene CHEBI:15355 acetylcholine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000109 Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] PMID:10666054 12242625 KCNJ6 potassium inwardly rectifying channel subfamily J member 6 gene CHEBI:26216 potassium atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011188 [KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] PMID:10666054 12242625 KCNJ6 potassium inwardly rectifying channel subfamily J member 6 gene CHEBI:32595 barium(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D001464 Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] PMID:10666054 12243013 FGF7 fibroblast growth factor 7 gene CHEBI:17883 hydrogen chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D006851 Hydrochloric Acid results in increased expression of FGF7 mRNA PMID:15883737 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:15367 all-trans-retinoic acid increases expression EXP E RGD:6480464 20191114 CTD MESH:D014212 Tretinoin results in increased expression of NOS3 mRNA; Tretinoin results in increased expression of NOS3 protein PMID:17267746 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:32020 pitavastatin increases activity EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in increased activity of NOS3 protein PMID:15502390 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:32020 pitavastatin increases expression EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in increased expression of NOS3 mRNA PMID:15502390 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:4784 enalapril increases expression EXP E RGD:6480464 20191114 CTD MESH:D004656 Enalapril results in increased expression of NOS3 mRNA PMID:12019275 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 FR 173657 inhibits the reaction [Enalapril results in increased expression of NOS3 mRNA] PMID:12019275 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:71260 pitavastatin(1-) increases activity EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in increased activity of NOS3 protein PMID:15502390 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:71260 pitavastatin(1-) increases expression EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in increased expression of NOS3 mRNA PMID:15502390 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:78420 icariin increases activity EXP E RGD:6480464 20191114 CTD MESH:C056599 icariin results in increased activity of NOS3 protein PMID:17438405 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:9150 simvastatin decreases expression EXP E RGD:6480464 20191114 CTD MESH:D019821 Simvastatin results in decreased expression of NOS3 mRNA PMID:11087217 12243345 NOS3 nitric oxide synthase 3 gene CHEBI:9150 simvastatin increases expression EXP E RGD:6480464 20191114 CTD MESH:D019821 Simvastatin results in increased expression of NOS3 protein PMID:11087217 12244264 OCLN occludin gene CHEBI:15367 all-trans-retinoic acid increases expression EXP E RGD:6480464 20191114 CTD MESH:D014212 Tretinoin results in increased expression of OCLN mRNA; Tretinoin results in increased expression of OCLN protein PMID:17035595 12244264 OCLN occludin gene CHEBI:15367 all-trans-retinoic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014212 CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA] PMID:17035595 12244264 OCLN occludin gene CHEBI:35456 cadmium dichloride decreases expression EXP E RGD:6480464 20191114 CTD MESH:D019256 Cadmium Chloride results in decreased expression of OCLN protein PMID:18418844 12244289 BIRC5 baculoviral IAP repeat containing 5 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of BIRC5 mRNA PMID:22747577 12244446 EGR1 early growth response 1 gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein PMID:18820026 12244446 EGR1 early growth response 1 gene CHEBI:6904 metoprolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008790 [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein PMID:18820026 12244446 EGR1 early growth response 1 gene CHEBI:87681 ranolazine affects expression EXP E RGD:6480464 20191114 CTD MESH:D000069458 Ranolazine affects the expression of EGR1 protein PMID:18820026 12244446 EGR1 early growth response 1 gene CHEBI:87681 ranolazine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000069458 [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein PMID:18820026 12245252 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of KCNMB4 mRNA PMID:27255383 12246481 SOD1 superoxide dismutase 1 gene CHEBI:37537 phorbol 13-acetate 12-myristate affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D013755 SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate PMID:6333936 12246481 SOD1 superoxide dismutase 1 gene CHEBI:7449 nafenopin affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D009255 SOD1 protein affects the susceptibility to Nafenopin PMID:6333936 12246481 SOD1 superoxide dismutase 1 gene CHEBI:77649 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D009255 SOD1 protein affects the susceptibility to Nafenopin PMID:6333936 12246481 SOD1 superoxide dismutase 1 gene CHEBI:8069 phenobarbital affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D010634 SOD1 protein affects the susceptibility to Phenobarbital PMID:6333936 12246503 ADRB2 adrenoceptor beta 2 gene CHEBI:135592 amosulalol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C032473 amosulalol binds to and results in decreased activity of ADRB2 protein PMID:6129981 12246503 ADRB2 adrenoceptor beta 2 gene CHEBI:18357 (R)-noradrenaline multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009638 [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine PMID:2884805 12246503 ADRB2 adrenoceptor beta 2 gene CHEBI:8499 propranolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011433 [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine PMID:2884805 12246586 TTR transthyretin gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of TTR mRNA] PMID:25419811 12246586 TTR transthyretin gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA] PMID:25419811 12246586 TTR transthyretin gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA] PMID:25419811 12246586 TTR transthyretin gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA] PMID:25419811 12246909 MIR15B microRNA mir-15b gene CHEBI:17833 gentamycin affects expression EXP E RGD:6480464 20210608 CTD MESH:D005839 Gentamicins affects the expression of MIR15B mRNA PMID:33290828 12247034 PLN phospholamban gene CHEBI:40279 allopurinol affects expression EXP E RGD:6480464 20191114 CTD MESH:D000493 Allopurinol affects the expression of PLN mRNA; Allopurinol affects the expression of PLN protein; Allopurinol affects the expression of PLN protein modified form PMID:17071724 12248831 NAPA NSF attachment protein alpha gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of NAPA protein PMID:32991862 12249132 VPS33A VPS33A core subunit of CORVET and HOPS complexes gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS33A mRNA PMID:27255383 12249312 UROS uroporphyrinogen III synthase gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of UROS mRNA PMID:22747577 12249792 VCPKMT valosin containing protein lysine methyltransferase gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of VCPKMT mRNA PMID:22747577 12250216 NCF1 neutrophil cytosolic factor 1 gene CHEBI:32020 pitavastatin decreases expression EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in decreased expression of NCF1 mRNA PMID:15502390 12250216 NCF1 neutrophil cytosolic factor 1 gene CHEBI:71260 pitavastatin(1-) decreases expression EXP E RGD:6480464 20191114 CTD MESH:C108475 pitavastatin results in decreased expression of NCF1 mRNA PMID:15502390 12250353 CAV1 caveolin 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of CAV1 mRNA PMID:27255383 12251833 SNX17 sorting nexin 17 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of SNX17 mRNA PMID:27255383 12252074 NPPA natriuretic peptide A gene CHEBI:18357 (R)-noradrenaline increases expression EXP E RGD:6480464 20191114 CTD MESH:D009638 Norepinephrine results in increased expression of NPPA protein PMID:8952593 12252074 NPPA natriuretic peptide A gene CHEBI:28918 (R)-adrenaline affects abundance EXP E RGD:6480464 20191114 CTD MESH:D004837 NPPA protein affects the abundance of Epinephrine PMID:2951327 12252074 NPPA natriuretic peptide A gene CHEBI:41879 dexamethasone increases expression EXP E RGD:6480464 20191114 CTD MESH:D003907 Dexamethasone results in increased expression of NPPA protein PMID:1934541 12252074 NPPA natriuretic peptide A gene CHEBI:4784 enalapril decreases expression EXP E RGD:6480464 20191114 CTD MESH:D004656 Enalapril results in decreased expression of NPPA protein PMID:12019275 12252074 NPPA natriuretic peptide A gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 FR 173657 inhibits the reaction [Enalapril results in decreased expression of NPPA protein] PMID:12019275 12252074 NPPA natriuretic peptide A gene CHEBI:8499 propranolol increases expression EXP E RGD:6480464 20191114 CTD MESH:D011433 Propranolol results in increased expression of NPPA protein PMID:2566282 12252219 TNFSF10 TNF superfamily member 10 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TNFSF10 mRNA PMID:22747577 12252592 CHMP4B charged multivesicular body protein 4B gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of CHMP4B mRNA PMID:27255383 12252833 ALOX5 arachidonate 5-lipoxygenase gene CHEBI:10112 zileuton decreases activity EXP E RGD:6480464 20191114 CTD MESH:C063449 zileuton results in decreased activity of ALOX5 protein PMID:1618819 12253291 CLEC2B C-type lectin domain family 2 member B gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of CLEC2B mRNA PMID:22747577 12253987 AGRN agrin gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of AGRN mRNA PMID:22747577 12254561 BLOC1S1 biogenesis of lysosomal organelles complex 1 subunit 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of BLOC1S1 mRNA PMID:27255383 12255685 TARDBP TAR DNA binding protein gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of TARDBP protein PMID:22747577 12256662 CAMK1D calcium/calmodulin dependent protein kinase ID gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of CAMK1D mRNA PMID:27255383 12257206 TMED2 transmembrane p24 trafficking protein 2 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TMED2 mRNA PMID:27255383 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:168067 Acetyl tributyl citrate increases activity EXP E RGD:6480464 20210504 CTD MESH:C014953 2-acetyltributylcitrate results in increased activity of NR1I2 protein PMID:21742782 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:28077 rifampicin increases activity EXP E RGD:6480464 20191114 CTD MESH:D012293 Rifampin results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:31429 colforsin daropate hydrochloride increases activity EXP E RGD:6480464 20191114 CTD MESH:D005576 Colforsin results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:3764 clotrimazole increases activity EXP E RGD:6480464 20191114 CTD MESH:D003022 Clotrimazole results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:45409 ritonavir increases activity EXP E RGD:6480464 20191114 CTD MESH:D019438 Ritonavir results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:45735 troleandomycin increases activity EXP E RGD:6480464 20191114 CTD MESH:D014217 Troleandomycin results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:47318 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime increases activity EXP E RGD:6480464 20191114 CTD MESH:C475093 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:585948 felodipine increases activity EXP E RGD:6480464 20191114 CTD MESH:D015736 Felodipine results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:77260 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole increases activity EXP E RGD:6480464 20191114 CTD MESH:D009853 Omeprazole results in increased activity of NR1I2 protein PMID:27732639 12257278 NR1I2 nuclear receptor subfamily 1 group I member 2 gene CHEBI:7772 omeprazole increases activity EXP E RGD:6480464 20191114 CTD MESH:D009853 Omeprazole results in increased activity of NR1I2 protein PMID:27732639 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:16240 hydrogen peroxide increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D006861 Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein PMID:23816505 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:16240 hydrogen peroxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006861 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] PMID:23816505 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:16856 glutathione multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005978 Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] PMID:23816505 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:17924 D-glucitol increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D013012 Sorbitol results in increased phosphorylation of MAPK1 protein PMID:12639917 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:26710 sodium chloride increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased phosphorylation of MAPK1 protein PMID:23816505 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:26710 sodium chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012965 Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] PMID:23816505 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:27563 arsenic atom increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D001151 Arsenic results in increased phosphorylation of MAPK1 protein PMID:29306782 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:28939 N-acetyl-L-cysteine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000111 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] PMID:23816505 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:30621 diarsenic trioxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C006632 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein PMID:23236503 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:31429 colforsin daropate hydrochloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005576 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein PMID:12639917 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:37537 phorbol 13-acetate 12-myristate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013755 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein PMID:12639917 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:47217 arsane increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D001151 Arsenic results in increased phosphorylation of MAPK1 protein PMID:29306782 12258672 MAPK1 mitogen-activated protein kinase 1 gene CHEBI:49900 arsenous acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C032793 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein PMID:23236503 12258978 TBC1D14 TBC1 domain family member 14 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of TBC1D14 mRNA PMID:22747577 12259272 EP300 E1A binding protein p300 gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20200128 CTD MESH:C059514 [[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein; Resveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein] PMID:21239502 12260125 CASP8 caspase 8 gene CHEBI:132230 marbofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:C080260 marbofloxacin results in increased expression of CASP8 mRNA PMID:31005593 12260125 CASP8 caspase 8 gene CHEBI:132230 marbofloxacin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C080260 TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA] PMID:31005593 12260125 CASP8 caspase 8 gene CHEBI:51403 1,4-phenylenediamine increases activity EXP E RGD:6480464 20191114 CTD MESH:C029728 4-phenylenediamine results in increased activity of CASP8 protein PMID:20156547 12260125 CASP8 caspase 8 gene CHEBI:51403 1,4-phenylenediamine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C029728 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP8 protein] PMID:20156547 12260125 CASP8 caspase 8 gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of CASP8 mRNA PMID:24582689 12260125 CASP8 caspase 8 gene CHEBI:7731 ofloxacin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D015242 TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] PMID:24582689 12261435 ACADVL acyl-CoA dehydrogenase very long chain gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of ACADVL protein PMID:19952500 12261866 BHMT betaine--homocysteine S-methyltransferase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of BHMT protein PMID:19952500 12262056 PHF10 PHD finger protein 10 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PHF10 mRNA PMID:22747577 12263390 DLGAP1 DLG associated protein 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of DLGAP1 mRNA PMID:22747577 12263533 MAB21L2 mab-21 like 2 gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of MAB21L2 mRNA] PMID:25419811 12263533 MAB21L2 mab-21 like 2 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA] PMID:25419811 12263533 MAB21L2 mab-21 like 2 gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA] PMID:25419811 12263533 MAB21L2 mab-21 like 2 gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA] PMID:25419811 12264151 CAST calpastatin gene CHEBI:9241 spironolactone increases expression EXP E RGD:6480464 20191114 CTD MESH:D013148 Spironolactone results in increased expression of CAST protein PMID:20082611 12264323 TTLL1 TTL family tubulin polyglutamylase complex subunit L1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of TTLL1 mRNA PMID:22747577 12265583 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of ATP1A1 mRNA PMID:27255383 12267221 AIG1 androgen induced 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of AIG1 mRNA PMID:22747577 12267755 HYAL3 hyaluronidase 3 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of HYAL3 mRNA PMID:22747577 12268039 ACTA2 actin alpha 2, smooth muscle gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 protein PMID:33543323 12268039 ACTA2 actin alpha 2, smooth muscle gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein] PMID:33543323 12269304 HSP90AA1 heat shock protein 90 alpha family class A member 1 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of HSP90AA1 protein PMID:32991862 12272567 WAPL WAPL cohesin release factor gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of WAPAL mRNA PMID:22747577 12275117 AGT angiotensinogen gene CHEBI:145568 cilazapril monohydrate decreases expression EXP E RGD:6480464 20200107 CTD MESH:D017315 Cilazapril results in decreased expression of AGT protein PMID:2419701 12275117 AGT angiotensinogen gene CHEBI:26523 reactive oxygen species multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D017382 Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] PMID:8021468 12275117 AGT angiotensinogen gene CHEBI:27584 aldosterone increases abundance EXP E RGD:6480464 20191114 CTD MESH:D000450 AGT results in increased abundance of Aldosterone PMID:2831029 12275117 AGT angiotensinogen gene CHEBI:28790 serotonin increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D012701 AGT protein modified form results in increased susceptibility to Serotonin PMID:8021468 12275117 AGT angiotensinogen gene CHEBI:28790 serotonin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012701 Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]; Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] PMID:8021468 12275117 AGT angiotensinogen gene CHEBI:4356 desferrioxamine B multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003676 Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] PMID:8021468 12276421 MT2A metallothionein 1H gene CHEBI:31823 mercury dichloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D008627 Mercuric Chloride results in increased expression of MT2 mRNA PMID:15590114 12277402 CRH corticotropin releasing hormone gene CHEBI:17650 cortisol increases abundance EXP E RGD:6480464 20191114 CTD MESH:D006854 CRH protein results in increased abundance of Hydrocortisone PMID:2831029 12278725 SFT2D1 SFT2 domain containing 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of SFT2D1 mRNA PMID:27255383 12278777 SLC25A12 solute carrier family 25 member 12 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of SLC25A12 protein PMID:32991862 12278777 SLC25A12 solute carrier family 25 member 12 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of SLC25A12 mRNA PMID:22747577 12278824 TM2D2 TM2 domain containing 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TM2D2 mRNA PMID:22747577 12279055 CRYZ crystallin zeta gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of CRYZ protein PMID:19952500 12279429 EPHX1 epoxide hydrolase 1 gene CHEBI:17907 styrene oxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C013690 CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] PMID:12051674 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:135004 nefiracetam affects expression EXP E RGD:6480464 20191114 CTD MESH:C058876 nefiracetam affects the expression of PTGS2 mRNA PMID:16105799 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:135004 nefiracetam increases expression EXP E RGD:6480464 20191114 CTD MESH:C058876 nefiracetam results in increased expression of PTGS2 protein PMID:16105799 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:28119 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP E RGD:6480464 20191114 CTD MESH:D013749 Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA; Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein PMID:8660662 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:32243 tolfenamic acid decreases expression EXP E RGD:6480464 20191114 CTD MESH:C009500 tolfenamic acid results in decreased expression of PTGS2 mRNA PMID:15198222 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:364453 carprofen decreases expression EXP E RGD:6480464 20191114 CTD MESH:C007005 carprofen results in decreased expression of PTGS2 mRNA PMID:15198222 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:44445 nimesulide decreases expression EXP E RGD:6480464 20191114 CTD MESH:C012655 nimesulide results in decreased expression of PTGS2 mRNA PMID:15198222 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:4909 etodolac decreases expression EXP E RGD:6480464 20191114 CTD MESH:D017308 Etodolac results in decreased expression of PTGS2 mRNA PMID:15198222 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:5855 ibuprofen increases expression EXP E RGD:6480464 20191114 CTD MESH:D007052 Ibuprofen results in increased expression of PTGS2 protein PMID:16105799 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:73458 NS-398 decreases expression EXP E RGD:6480464 20191114 CTD MESH:C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 protein PMID:12857884|PMID:15198222 12279597 PTGS2 prostaglandin-endoperoxide synthase 2 gene CHEBI:9352 sulindac decreases expression EXP E RGD:6480464 20191114 CTD MESH:D013467 Sulindac results in decreased expression of PTGS2 protein PMID:12857884 12279693 ACTL7A actin like 7A gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ACTL7A mRNA PMID:22747577 12280604 ACOX2 acyl-CoA oxidase 2 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of ACOX2 mRNA PMID:19952500 12280894 CIAPIN1 cytokine induced apoptosis inhibitor 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of CIAPIN1 mRNA PMID:22747577 12281399 POMC proopiomelanocortin gene CHEBI:17650 cortisol increases abundance EXP E RGD:6480464 20191114 CTD MESH:D006854 POMC protein results in increased abundance of Hydrocortisone PMID:2831029 12281399 POMC proopiomelanocortin gene CHEBI:18357 (R)-noradrenaline increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D009638 POMC protein results in increased susceptibility to Norepinephrine PMID:6279499 12281399 POMC proopiomelanocortin gene CHEBI:27584 aldosterone increases abundance EXP E RGD:6480464 20191114 CTD MESH:D000450 POMC protein results in increased abundance of Aldosterone PMID:2831029 12281399 POMC proopiomelanocortin gene CHEBI:6954 Mitotane increases expression EXP E RGD:6480464 20191114 CTD MESH:D008939 Mitotane results in increased expression of POMC protein alternative form PMID:8453685 12281399 POMC proopiomelanocortin gene CHEBI:7457 Nalmefene increases expression EXP E RGD:6480464 20191114 CTD MESH:C038981 nalmefene results in increased expression of POMC protein alternative form PMID:3026683 12281399 POMC proopiomelanocortin gene CHEBI:7459 naloxone increases expression EXP E RGD:6480464 20191114 CTD MESH:D009270 Naloxone results in increased expression of POMC protein PMID:8277081 12281399 POMC proopiomelanocortin gene CHEBI:7596 nitroprusside increases expression EXP E RGD:6480464 20191114 CTD MESH:D009599 Nitroprusside results in increased expression of POMC protein PMID:2831029 12284259 ABCB11 ATP binding cassette subfamily B member 11 gene CHEBI:75379 blebbistatin decreases localization EXP E RGD:6480464 20191114 CTD MESH:C472645 blebbistatin results in decreased localization of ABCB11 protein PMID:15826951 12284512 THEMIS2 thymocyte selection associated family member 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of THEMIS2 mRNA PMID:22747577 12284676 VPS26A VPS26, retromer complex component A gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS26A mRNA PMID:27255383 12287062 MYC MYC proto-oncogene, bHLH transcription factor gene CHEBI:31401 cilostazol decreases expression EXP E RGD:6480464 20191114 CTD MESH:C045645 Cilostazol results in decreased expression of MYC mRNA PMID:19545562 12287448 DPYSL3 dihydropyrimidinase like 3 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of DPYSL3 mRNA PMID:22747577 12288301 MMP9 matrix metallopeptidase 9 gene CHEBI:15379 dioxygen multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D010100 Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein] PMID:18339021 12288301 MMP9 matrix metallopeptidase 9 gene CHEBI:17883 hydrogen chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D006851 Hydrochloric Acid results in increased expression of MMP9 protein PMID:18339021 12288301 MMP9 matrix metallopeptidase 9 gene CHEBI:17883 hydrogen chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006851 Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein] PMID:18339021 12288301 MMP9 matrix metallopeptidase 9 gene CHEBI:9241 spironolactone decreases expression EXP E RGD:6480464 20191114 CTD MESH:D013148 Spironolactone results in decreased expression of MMP9 protein PMID:20082611 12289273 MGST3 microsomal glutathione S-transferase 3 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of MGST3 mRNA PMID:19952500 12289830 CAPG capping actin protein, gelsolin like gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CAPG protein PMID:22747577 12290254 ANK3 ankyrin 3 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of ANK3 mRNA PMID:27255383 12290491 GDI1 GDP dissociation inhibitor 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of GDI1 protein PMID:19952500 12290611 UCHL3 ubiquitin C-terminal hydrolase L3 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of UCHL3 protein PMID:22747577 12290979 SHMT1 serine hydroxymethyltransferase 1 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of SHMT1 protein PMID:19952500 12292179 RCAN1 regulator of calcineurin 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of RCAN1 mRNA PMID:22747577 12294444 SLC6A9 solute carrier family 6 member 9 gene CHEBI:27617 monensin A affects localization EXP E RGD:6480464 20191114 CTD MESH:D008985 Monensin affects the localization of SLC6A9 protein PMID:19473961 12294444 SLC6A9 solute carrier family 6 member 9 gene CHEBI:27617 monensin A multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008985 Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein] PMID:19473961 12294444 SLC6A9 solute carrier family 6 member 9 gene CHEBI:37537 phorbol 13-acetate 12-myristate affects localization EXP E RGD:6480464 20191114 CTD MESH:D013755 Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein PMID:19473961 12294444 SLC6A9 solute carrier family 6 member 9 gene CHEBI:37537 phorbol 13-acetate 12-myristate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013755 Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein] PMID:19473961 12294532 TSG101 tumor susceptibility 101 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TSG101 mRNA PMID:27255383 12295839 SNX15 sorting nexin 15 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of SNX15 mRNA PMID:27255383 12296742 DLGAP5 DLG associated protein 5 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of DLGAP5 mRNA PMID:22747577 12296991 SP1 Sp1 transcription factor gene CHEBI:26710 sodium chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased expression of SP1 protein PMID:23816505 12296991 SP1 Sp1 transcription factor gene CHEBI:26710 sodium chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012965 pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] PMID:23816505 12296991 SP1 Sp1 transcription factor gene CHEBI:90695 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C432165 pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] PMID:23816505 12299714 HADH hydroxyacyl-CoA dehydrogenase gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of HADH mRNA PMID:19952500 12299714 HADH hydroxyacyl-CoA dehydrogenase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of HADH mRNA PMID:19952500 12301253 KIF5A kinesin family member 5A gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of KIF5A mRNA PMID:27255383 12302435 COMMD1 copper metabolism domain containing 1 gene CHEBI:28694 copper atom decreases export EXP E RGD:6480464 20191114 CTD MESH:D003300 COMMD1 gene mutant form results in decreased export of Copper PMID:20433422 12302435 COMMD1 copper metabolism domain containing 1 gene CHEBI:28694 copper atom increases abundance EXP E RGD:6480464 20191114 CTD MESH:D003300 COMMD1 gene mutant form results in increased abundance of Copper PMID:22879914 12302435 COMMD1 copper metabolism domain containing 1 gene CHEBI:30052 copper(0) decreases export EXP E RGD:6480464 20191114 CTD MESH:D003300 COMMD1 gene mutant form results in decreased export of Copper PMID:20433422 12302435 COMMD1 copper metabolism domain containing 1 gene CHEBI:30052 copper(0) increases abundance EXP E RGD:6480464 20191114 CTD MESH:D003300 COMMD1 gene mutant form results in increased abundance of Copper PMID:22879914 12303620 ETFDH electron transfer flavoprotein dehydrogenase gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ETFDH mRNA PMID:22747577 12304097 KCNJ3 potassium inwardly rectifying channel subfamily J member 3 gene CHEBI:15355 acetylcholine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000109 Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] PMID:10666054 12304097 KCNJ3 potassium inwardly rectifying channel subfamily J member 3 gene CHEBI:26216 potassium atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011188 [KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] PMID:10666054 12304097 KCNJ3 potassium inwardly rectifying channel subfamily J member 3 gene CHEBI:32595 barium(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D001464 Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] PMID:10666054 12304129 GLRA1 glycine receptor alpha 1 gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GLRA1 mRNA] PMID:25419811 12304129 GLRA1 glycine receptor alpha 1 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA] PMID:25419811 12304129 GLRA1 glycine receptor alpha 1 gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA] PMID:25419811 12304129 GLRA1 glycine receptor alpha 1 gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA] PMID:25419811 12304674 HRC histidine rich calcium binding protein gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of HRC mRNA PMID:27255383 12305033 ABITRAM actin binding transcription modulator gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ABITRAM mRNA PMID:22747577 12305715 SLC47A1 solute carrier family 47 member 1 gene CHEBI:38000 uniconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C092705 uniconazole results in decreased activity of SLC47A1 protein PMID:36669674 12305715 SLC47A1 solute carrier family 47 member 1 gene CHEBI:81766 hexaconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C409722 hexaconazole results in decreased activity of SLC47A1 protein PMID:36669674 12305715 SLC47A1 solute carrier family 47 member 1 gene CHEBI:81781 tebuconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087114 tebuconazole results in decreased activity of SLC47A1 protein PMID:36669674 12305715 SLC47A1 solute carrier family 47 member 1 gene CHEBI:81970 penconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087058 penconazole results in decreased activity of SLC47A1 protein PMID:36669674 12305715 SLC47A1 solute carrier family 47 member 1 gene CHEBI:81980 triticonazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C412303 triticonazole results in decreased activity of SLC47A1 protein PMID:36669674 12306176 UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of UQCC mRNA PMID:22747577 12306340 ARMC12 armadillo repeat containing 12 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ARMC12 mRNA PMID:22747577 12306353 LOC474938 glutathione S-transferase A2 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein PMID:19952500 12306353 LOC474938 glutathione S-transferase A2 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of GSTA3 protein PMID:19952500 12308896 PARP14 poly(ADP-ribose) polymerase family member 14 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PARP14 mRNA PMID:22747577 12309295 XIAP X-linked inhibitor of apoptosis gene CHEBI:28748 doxorubicin affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D004317 XIAP affects the susceptibility to Doxorubicin PMID:16953886 12309515 IL31RA interleukin 31 receptor A gene CHEBI:15864 luteolin multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D047311 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of IL31RA promoter PMID:33763461 12309515 IL31RA interleukin 31 receptor A gene CHEBI:69478 cannabidiol multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D002185 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of IL31RA promoter PMID:33763461 12309823 UROD uroporphyrinogen decarboxylase gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of UROD protein PMID:22747577 12310262 TOX thymocyte selection associated high mobility group box gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TOX mRNA PMID:22747577 12311221 PC pyruvate carboxylase gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of PC protein PMID:32991862 12311221 PC pyruvate carboxylase gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of PC protein PMID:19952500 12311506 RASGRP2 RAS guanyl releasing protein 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of RASGRP2 mRNA PMID:22747577 12312469 POR cytochrome p450 oxidoreductase gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of POR mRNA PMID:22747577 12312848 DRD2 dopamine receptor D2 gene CHEBI:26421 pyridines multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011725 Pyridines analog binds to and results in decreased activity of DRD2 protein PMID:12593651 12312848 DRD2 dopamine receptor D2 gene CHEBI:8871 risperidone multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D018967 Risperidone binds to and results in decreased activity of DRD2 protein PMID:16948927 12315254 SMC5 structural maintenance of chromosomes 5 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of SMC5 mRNA PMID:22747577 12317496 LOC607874 cystatin-C-like gene CHEBI:17833 gentamycin increases expression EXP E RGD:6480464 20210608 CTD MESH:D005839 Gentamicins results in increased expression of CST3 protein PMID:33290828 12317599 STON1 stonin 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of STON1 mRNA PMID:27255383 12318220 DNM1L dynamin 1 like gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of DNM1L mRNA PMID:27255383 12319222 AGO2 argonaute RISC catalytic component 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of AGO2 mRNA PMID:22747577 12320140 RUNX2 RUNX family transcription factor 2 gene CHEBI:17154 nicotinamide decreases expression EXP E RGD:6480464 20210114 CTD MESH:D009536 Niacinamide results in decreased expression of RUNX2 protein PMID:22539994 12320140 RUNX2 RUNX family transcription factor 2 gene CHEBI:17154 nicotinamide increases acetylation EXP E RGD:6480464 20210114 CTD MESH:D009536 Niacinamide results in increased acetylation of RUNX2 protein PMID:22539994 12320140 RUNX2 RUNX family transcription factor 2 gene CHEBI:17154 nicotinamide multiple interactions EXP E RGD:6480464 20210114 CTD MESH:D009536 Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein] PMID:22539994 12320140 RUNX2 RUNX family transcription factor 2 gene CHEBI:27881 resveratrol decreases acetylation EXP E RGD:6480464 20210114 CTD MESH:C059514 Resveratrol results in decreased acetylation of RUNX2 protein PMID:22539994 12320140 RUNX2 RUNX family transcription factor 2 gene CHEBI:27881 resveratrol increases expression EXP E RGD:6480464 20210114 CTD MESH:C059514 Resveratrol results in increased expression of RUNX2 protein PMID:22539994 12320140 RUNX2 RUNX family transcription factor 2 gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20210114 CTD MESH:C059514 [Resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of RUNX2 protein]; Resveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein]; Resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein]; SIRT1 protein affects the reaction [Resveratrol results in decreased acetylation of RUNX2 protein] PMID:21239502|PMID:22539994 12321161 LOC477072 serotransferrin gene CHEBI:18248 iron atom increases export EXP E RGD:6480464 20191114 CTD MESH:D007501 TF protein results in increased export of Iron PMID:16806171 12321161 LOC477072 serotransferrin gene CHEBI:18248 iron atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007501 [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] PMID:16806171 12321161 LOC477072 serotransferrin gene CHEBI:82664 iron(0) increases export EXP E RGD:6480464 20191114 CTD MESH:D007501 TF protein results in increased export of Iron PMID:16806171 12321161 LOC477072 serotransferrin gene CHEBI:82664 iron(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007501 [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] PMID:16806171 12321204 SNAP23 synaptosome associated protein 23 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SNAP23 mRNA PMID:27255383 12322085 CHMP6 charged multivesicular body protein 6 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of CHMP6 mRNA PMID:27255383 12322318 BCAP29 B cell receptor associated protein 29 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of BCAP29 mRNA PMID:27255383 12323923 LOC478000 phytanoyl-CoA hydroxylase-like gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PHYH mRNA PMID:22747577 12324640 TERT telomerase reverse transcriptase gene CHEBI:28119 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP E RGD:6480464 20191114 CTD MESH:D013749 Tetrachlorodibenzodioxin results in decreased expression of TERT protein PMID:23850740 12324640 TERT telomerase reverse transcriptase gene CHEBI:64090 tert-butyl hydroperoxide increases activity EXP E RGD:6480464 20191114 CTD MESH:D020122 tert-Butylhydroperoxide results in increased activity of TERT protein PMID:14729356 12324659 UGP2 UDP-glucose pyrophosphorylase 2 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of UGP2 protein PMID:19952500 12325106 TTC38 tetratricopeptide repeat domain 38 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TTC38 protein PMID:22747577 12327259 TCN2 transcobalamin 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TCN2 mRNA PMID:22747577 12327617 LONRF1 LON peptidase N-terminal domain and ring finger 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of LONRF1 mRNA PMID:22747577 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:15365 acetylsalicylic acid decreases activity EXP E RGD:6480464 20191114 CTD MESH:D001241 Aspirin results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:31225 antipyrine decreases activity EXP E RGD:6480464 20191114 CTD MESH:D000983 Antipyrine results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:32169 Sulpyrine decreases activity EXP E RGD:6480464 20191114 CTD MESH:D004177 Dipyrone results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:46195 paracetamol decreases activity EXP E RGD:6480464 20191114 CTD MESH:D000082 Acetaminophen results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:47381 diclofenac decreases activity EXP E RGD:6480464 20191114 CTD MESH:D004008 Diclofenac results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:49662 indometacin decreases activity EXP E RGD:6480464 20191114 CTD MESH:D007213 Indomethacin results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:5855 ibuprofen decreases activity EXP E RGD:6480464 20191114 CTD MESH:D007052 Ibuprofen results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:59033 metamizole sodium decreases activity EXP E RGD:6480464 20191114 CTD MESH:D004177 Dipyrone results in decreased activity of PTGS1 protein alternative form PMID:12242329 12328669 PTGS1 prostaglandin-endoperoxide synthase 1 gene CHEBI:8050 phenacetin decreases activity EXP E RGD:6480464 20191114 CTD MESH:D010615 Phenacetin results in decreased activity of PTGS1 protein alternative form PMID:12242329 12330261 SNAPIN SNAP associated protein gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of SNAPIN mRNA PMID:27255383 12330954 GJA1 gap junction protein alpha 1 gene CHEBI:35807 N-nitrosodimethylamine decreases expression EXP E RGD:6480464 20191114 CTD MESH:D004128 Dimethylnitrosamine results in decreased expression of GJA1 protein PMID:15736408 12330959 AR androgen receptor gene CHEBI:31547 eplerenone multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C414690 Eplerenone binds to and results in decreased activity of AR protein PMID:23242577 12331435 CASQ1 calsequestrin 1 gene CHEBI:45716 vorinostat decreases expression EXP E RGD:6480464 20191114 CTD MESH:C111237 Vorinostat results in decreased expression of CASQ1 mRNA PMID:27255383 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:22984 calcium atom increases transport EXP E RGD:6480464 20191114 CTD MESH:D002118 SLC8A1 protein results in increased transport of Calcium PMID:15375168 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:22984 calcium atom increases uptake EXP E RGD:6480464 20191114 CTD MESH:D002118 SLC8A1 protein results in increased uptake of Calcium PMID:14660663 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:22984 calcium atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002118 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium] PMID:14660663|PMID:15375168 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:2663 amiodarone decreases activity EXP E RGD:6480464 20191114 CTD MESH:D000638 Amiodarone results in decreased activity of SLC8A1 protein PMID:15288574 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:29320 calcium(0) increases transport EXP E RGD:6480464 20191114 CTD MESH:D002118 SLC8A1 protein results in increased transport of Calcium PMID:15375168 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:29320 calcium(0) increases uptake EXP E RGD:6480464 20191114 CTD MESH:D002118 SLC8A1 protein results in increased uptake of Calcium PMID:14660663 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:29320 calcium(0) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002118 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium] PMID:14660663|PMID:15375168 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:40279 allopurinol affects expression EXP E RGD:6480464 20191114 CTD MESH:D000493 Allopurinol affects the expression of SLC8A1 mRNA; Allopurinol affects the expression of SLC8A1 protein PMID:17071724 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein PMID:18820026 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:6904 metoprolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008790 [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein PMID:18820026 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:87681 ranolazine affects expression EXP E RGD:6480464 20191114 CTD MESH:D000069458 Ranolazine affects the expression of SLC8A1 protein PMID:18820026 12334269 SLC8A1 solute carrier family 8 member A1 gene CHEBI:87681 ranolazine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000069458 [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein PMID:18820026 12335203 CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of CACNB3 mRNA PMID:27255383 12335345 DLA-12 MHC class I DLA-12 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of DLA-12 mRNA PMID:22747577 12336473 IDH1 isocitrate dehydrogenase (NADP(+)) 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of IDH1 protein PMID:19952500 12337614 HSP90B1 heat shock protein 90 beta family member 1 gene CHEBI:29699 tunicamycin increases expression EXP E RGD:6480464 20191114 CTD MESH:D014415 Tunicamycin results in increased expression of HSP90B1 protein PMID:17416481 12337614 HSP90B1 heat shock protein 90 beta family member 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of HSP90B1 protein PMID:22747577 12338015 SEC24B SEC24 homolog B, COPII coat complex component gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SEC24B mRNA PMID:27255383 12338361 NISCH nischarin gene CHEBI:3757 clonidine (imino form) affects binding EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine binds to NISCH protein PMID:24120658 12338361 NISCH nischarin gene CHEBI:3757 clonidine (imino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] PMID:24120658 12338361 NISCH nischarin gene CHEBI:4466 dexmedetomidine affects activity EXP E RGD:6480464 20191114 CTD MESH:D020927 Dexmedetomidine affects the activity of NISCH PMID:7486159 12338361 NISCH nischarin gene CHEBI:46631 clonidine affects binding EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine binds to NISCH protein PMID:24120658 12338361 NISCH nischarin gene CHEBI:46631 clonidine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] PMID:24120658 12338361 NISCH nischarin gene CHEBI:46632 clonidine (amino form) affects binding EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine binds to NISCH protein PMID:24120658 12338361 NISCH nischarin gene CHEBI:46632 clonidine (amino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] PMID:24120658 12338361 NISCH nischarin gene CHEBI:5862 idazoxan multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D019329 Idazoxan binds to and results in decreased activity of NISCH protein PMID:8732285 12338361 NISCH nischarin gene CHEBI:93363 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole affects binding EXP E RGD:6480464 20191114 CTD MESH:D009278 Naphazoline binds to NISCH protein PMID:24120658 12338361 NISCH nischarin gene CHEBI:93363 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009278 Guanine Nucleotides inhibits the reaction [Naphazoline binds to NISCH protein] PMID:24120658 12338615 CASP9 caspase 9 gene CHEBI:4629 diosgenin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004144 Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein] PMID:25446497 12338615 CASP9 caspase 9 gene CHEBI:51403 1,4-phenylenediamine increases activity EXP E RGD:6480464 20191114 CTD MESH:C029728 4-phenylenediamine results in increased activity of CASP9 protein PMID:20156547 12338615 CASP9 caspase 9 gene CHEBI:51403 1,4-phenylenediamine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C029728 benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP9 protein] PMID:20156547 12338615 CASP9 caspase 9 gene CHEBI:60579 calcium oxalate increases activity EXP E RGD:6480464 20191114 CTD MESH:D002129 Calcium Oxalate results in increased activity of CASP9 protein PMID:25446497 12338615 CASP9 caspase 9 gene CHEBI:60579 calcium oxalate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002129 Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein] PMID:25446497 12340549 HPD 4-hydroxyphenylpyruvate dioxygenase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of HPD protein PMID:19952500 12340943 KCNK1 potassium two pore domain channel subfamily K member 1 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of KCNK1 mRNA PMID:27255383 12341758 AMN1 antagonist of mitotic exit network 1 homolog gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of AMN1 mRNA PMID:22747577 12342201 SLC47A2 solute carrier family 47 member 2 gene CHEBI:81766 hexaconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C409722 hexaconazole results in decreased activity of SLC47A2 protein PMID:36669674 12342201 SLC47A2 solute carrier family 47 member 2 gene CHEBI:81781 tebuconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087114 tebuconazole results in decreased activity of SLC47A2 protein PMID:36669674 12342201 SLC47A2 solute carrier family 47 member 2 gene CHEBI:81970 penconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087058 penconazole results in decreased activity of SLC47A2 protein PMID:36669674 12342642 ACAA1 acetyl-CoA acyltransferase 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of ACAA1 mRNA PMID:19952500 12342968 SLA Src like adaptor gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of SLA mRNA PMID:22747577 12344307 R3HDM2 R3H domain containing 2 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of R3HDM2 mRNA PMID:22747577 12344516 VIP vasoactive intestinal peptide gene CHEBI:27638 cobalt atom decreases expression EXP E RGD:6480464 20191114 CTD MESH:D003035 Cobalt results in decreased expression of VIP protein PMID:3711722 12344516 VIP vasoactive intestinal peptide gene CHEBI:28748 doxorubicin decreases expression EXP E RGD:6480464 20191114 CTD MESH:D004317 Doxorubicin results in decreased expression of VIP protein PMID:3711722 12344516 VIP vasoactive intestinal peptide gene CHEBI:8499 propranolol decreases expression EXP E RGD:6480464 20191114 CTD MESH:D011433 Propranolol results in decreased expression of VIP protein PMID:2566282 12344768 ALB albumin gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of ALB mRNA] PMID:25419811 12344768 ALB albumin gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA] PMID:25419811 12344768 ALB albumin gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA] PMID:25419811 12344768 ALB albumin gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA] PMID:25419811 12344792 CPT1A carnitine palmitoyltransferase 1A gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of CPT1A mRNA PMID:19952500 12344815 HSP70 heat shock protein 70 gene CHEBI:16243 quercetin decreases expression EXP E RGD:6480464 20230307 CTD MESH:D011794 Quercetin results in decreased expression of HSP70 protein PMID:17009600 12344815 HSP70 heat shock protein 70 gene CHEBI:16412 lipopolysaccharide multiple interactions EXP E RGD:6480464 20230307 CTD MESH:D008070 HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] PMID:32899721 12344815 HSP70 heat shock protein 70 gene CHEBI:22977 cadmium atom increases expression EXP E RGD:6480464 20230307 CTD MESH:D002104 Cadmium results in increased expression of HSP70 protein PMID:12915104 12344815 HSP70 heat shock protein 70 gene CHEBI:29678 sodium arsenite increases expression EXP E RGD:6480464 20230307 CTD MESH:C017947 sodium arsenite results in increased expression of HSP70 protein PMID:31940135 12344815 HSP70 heat shock protein 70 gene CHEBI:29678 sodium arsenite multiple interactions EXP E RGD:6480464 20230307 CTD MESH:C017947 carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]; leucinostatin A promotes the reaction [sodium arsenite results in increased expression of HSP70 protein] PMID:31940135 12344815 HSP70 heat shock protein 70 gene CHEBI:29866 arsenite(3-) increases expression EXP E RGD:6480464 20230307 CTD MESH:C015001 arsenite results in increased expression of HSP70 mRNA PMID:32899721 12344815 HSP70 heat shock protein 70 gene CHEBI:29866 arsenite(3-) multiple interactions EXP E RGD:6480464 20230307 CTD MESH:C015001 HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] PMID:32899721 12344815 HSP70 heat shock protein 70 gene CHEBI:3440 carvacrol multiple interactions EXP E RGD:6480464 20230307 CTD MESH:C073316 carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein] PMID:31940135 12344815 HSP70 heat shock protein 70 gene CHEBI:45716 vorinostat decreases expression EXP E RGD:6480464 20230307 CTD MESH:C111237 Vorinostat results in decreased expression of HSP70 mRNA PMID:27255383 12347185 DLA-64 MHC class I DLA-64 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of DLA-64 mRNA PMID:22747577 12347408 RELA RELA proto-oncogene, NF-kB subunit gene CHEBI:16412 lipopolysaccharide increases phosphorylation EXP E RGD:6480464 20220405 CTD MESH:D008070 Lipopolysaccharides results in increased phosphorylation of RELA protein PMID:32899721 12347408 RELA RELA proto-oncogene, NF-kB subunit gene CHEBI:16412 lipopolysaccharide multiple interactions EXP E RGD:6480464 20220405 CTD MESH:D008070 arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] PMID:32899721 12347408 RELA RELA proto-oncogene, NF-kB subunit gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C059514 [[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein; [Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased localization of and results in increased activity of RELA protein]; Resveratrol inhibits the reaction [TNFSF11 protein results in increased localization of and results in increased activity of RELA protein] PMID:21239502 12347408 RELA RELA proto-oncogene, NF-kB subunit gene CHEBI:29866 arsenite(3-) multiple interactions EXP E RGD:6480464 20220405 CTD MESH:C015001 arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] PMID:32899721 12347408 RELA RELA proto-oncogene, NF-kB subunit gene CHEBI:73458 NS-398 decreases localization EXP E RGD:6480464 20191114 CTD MESH:C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased localization of RELA protein PMID:12857884 12347408 RELA RELA proto-oncogene, NF-kB subunit gene CHEBI:9352 sulindac decreases localization EXP E RGD:6480464 20191114 CTD MESH:D013467 Sulindac results in decreased localization of RELA protein PMID:12857884 12349882 ACAA2 acetyl-CoA acyltransferase 2 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of ACAA2 mRNA PMID:19952500 12349882 ACAA2 acetyl-CoA acyltransferase 2 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of ACAA2 mRNA PMID:19952500 12351150 TNNI3K TNNI3 interacting kinase gene CHEBI:45716 vorinostat decreases expression EXP E RGD:6480464 20191114 CTD MESH:C111237 Vorinostat results in decreased expression of TNNI3K mRNA PMID:27255383 12351879 CYP3A26 cytochrome P450 3A26 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of CYP3A26 mRNA PMID:19952500 12351879 CYP3A26 cytochrome P450 3A26 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of CYP3A26 mRNA PMID:19952500 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:10033 warfarin increases hydroxylation EXP E RGD:6480464 20191114 CTD MESH:D014859 CYP3A12 protein results in increased hydroxylation of Warfarin PMID:12637241 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:17907 styrene oxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C013690 CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] PMID:12051674 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of CYP3A12 mRNA PMID:19952500 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:47519 ketoconazole decreases activity EXP E RGD:6480464 20191114 CTD MESH:D007654 Ketoconazole results in decreased activity of CYP3A12 protein PMID:15677349 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:47519 ketoconazole multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007654 Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] PMID:15677349 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:49575 diazepam increases hydroxylation EXP E RGD:6480464 20191114 CTD MESH:D003975 CYP3A12 protein results in increased hydroxylation of Diazepam PMID:15677349 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:49575 diazepam multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003975 Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] PMID:15677349 12351896 CYP3A12 cytochrome P-450 3A12 gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of CYP3A12 protein PMID:19952500 12353587 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase gene CHEBI:17361 cytidine 5'-monophosphate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003568 [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate PMID:2579070 12353587 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase gene CHEBI:24848 inositol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007294 [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate; Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides] PMID:2579070 12353587 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase gene CHEBI:32888 gamma-hexachlorocyclohexane affects activity EXP E RGD:6480464 20191114 CTD MESH:D001556 Hexachlorocyclohexane affects the activity of CDIPT protein PMID:2579070 12353587 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase gene CHEBI:32888 gamma-hexachlorocyclohexane multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D001556 [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate PMID:2579070 12353587 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase gene CHEBI:39095 delta-hexachlorocyclohexane decreases activity EXP E RGD:6480464 20191114 CTD MESH:C086916 delta-hexachlorocyclohexane results in decreased activity of CDIPT protein PMID:2579070 12353587 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase gene CHEBI:39095 delta-hexachlorocyclohexane multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C086916 [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate PMID:2579070 12353587 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase gene CHEBI:53013 3'-CMP multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003568 [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate PMID:2579070 12353617 TMEM260 transmembrane protein 260 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TMEM260 mRNA PMID:22747577 12355366 CCL2 C-C motif chemokine ligand 2 gene CHEBI:15864 luteolin multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D047311 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL2 promoter PMID:33763461 12355366 CCL2 C-C motif chemokine ligand 2 gene CHEBI:17833 gentamycin increases expression EXP E RGD:6480464 20210608 CTD MESH:D005839 Gentamicins results in increased expression of CCL2 protein PMID:33290828 12355366 CCL2 C-C motif chemokine ligand 2 gene CHEBI:69478 cannabidiol multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D002185 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL2 promoter PMID:33763461 12357133 MYL9 myosin light chain 9 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog] PMID:20510202 12358149 KIF5C kinesin family member 5C gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of KIF5C mRNA PMID:27255383 12358542 KRT18 keratin 18 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of KRT18 protein PMID:19952500 12358831 ALDH5A1 aldehyde dehydrogenase 5 family member A1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of ALDH5A1 mRNA PMID:22747577 12359874 ECHS1 enoyl-CoA hydratase, short chain 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of ECHS1 protein PMID:19952500 12362351 B9D2 B9 domain containing 2 gene CHEBI:17347 testosterone increases expression EXP E RGD:6480464 20191114 CTD MESH:D013739 Testosterone results in increased expression of TGFB1 mRNA PMID:17157324 12362351 B9D2 B9 domain containing 2 gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of TGFB1 mRNA; ochratoxin A results in increased expression of TGFB1 protein PMID:33543323 12362351 B9D2 B9 domain containing 2 gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein] PMID:33543323 12362811 CAMK2G calcium/calmodulin dependent protein kinase II gamma gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CAMK2G mRNA PMID:22747577 12362885 STYXL1 serine/threonine/tyrosine interacting like 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of STYXL1 mRNA PMID:22747577 12364239 NLRP3 NLR family pyrin domain containing 3 gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of NLRP3 mRNA; ochratoxin A results in increased expression of NLRP3 protein PMID:33543323 12364239 NLRP3 NLR family pyrin domain containing 3 gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein] PMID:33543323 12365506 ADRB1 adrenoceptor beta 1 gene CHEBI:135359 denopamine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C037293 denopamine binds to and results in increased activity of ADRB1 protein PMID:3831029 12365506 ADRB1 adrenoceptor beta 1 gene CHEBI:135592 amosulalol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C032473 amosulalol binds to and results in decreased activity of ADRB1 protein PMID:6129981 12365506 ADRB1 adrenoceptor beta 1 gene CHEBI:18357 (R)-noradrenaline increases activity EXP E RGD:6480464 20191114 CTD MESH:D009638 Norepinephrine results in increased activity of ADRB1 protein PMID:10344530 12365509 STING1 stimulator of interferon response cGAMP interactor 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of TMEM173 mRNA PMID:22747577 12365935 KLK6 kallikrein related peptidase 6 gene CHEBI:31516 Doramectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C084101 ABCB1 gene mutant form affects the reaction [doramectin affects the expression of KLK6 mRNA] PMID:25419811 12365935 KLK6 kallikrein related peptidase 6 gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA] PMID:25419811 12365935 KLK6 kallikrein related peptidase 6 gene CHEBI:50345 milbemycin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C027837 ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA] PMID:25419811 12365935 KLK6 kallikrein related peptidase 6 gene CHEBI:6078 ivermectin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007559 ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA] PMID:25419811 12366564 ANKRD26 ankyrin repeat domain containing 26 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ANKRD26 mRNA PMID:22747577 12366906 POLE2 DNA polymerase epsilon 2, accessory subunit gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of DNAAF2 mRNA PMID:27255383 12367266 OGT O-linked N-acetylglucosamine (GlcNAc) transferase gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of OGT mRNA PMID:22747577 12368635 PTH parathyroid hormone gene CHEBI:31801 Maxacalcitol decreases expression EXP E RGD:6480464 20191114 CTD MESH:C051883 maxacalcitol results in decreased expression of PTH protein PMID:10027919 12368635 PTH parathyroid hormone gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PTH mRNA PMID:22747577 12370161 INS insulin gene CHEBI:17234 glucose decreases abundance EXP E RGD:6480464 20191114 CTD MESH:D005947 INS protein results in decreased abundance of Glucose PMID:1646414 12370161 INS insulin gene CHEBI:17234 glucose multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005947 [INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin PMID:1013176|PMID:140932 12370161 INS insulin gene CHEBI:17634 D-glucose decreases abundance EXP E RGD:6480464 20191114 CTD MESH:D005947 INS protein results in decreased abundance of Glucose PMID:1646414 12370161 INS insulin gene CHEBI:17634 D-glucose multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005947 [INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin PMID:1013176|PMID:140932 12370161 INS insulin gene CHEBI:17650 cortisol affects abundance EXP E RGD:6480464 20191114 CTD MESH:D006854 INS protein affects the abundance of Hydrocortisone PMID:1324617 12370161 INS insulin gene CHEBI:17650 cortisol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006854 Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone] PMID:1324617 12370161 INS insulin gene CHEBI:26216 potassium atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011188 [INS protein co-treated with Glucose] results in decreased abundance of Potassium PMID:1013176|PMID:140932 12370161 INS insulin gene CHEBI:26708 sodium atom affects response to substance EXP E RGD:6480464 20191114 CTD MESH:D012964 INS protein affects the susceptibility to Sodium PMID:1324617 12370161 INS insulin gene CHEBI:26708 sodium atom multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012964 INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins]; Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone] PMID:1324617 12370161 INS insulin gene CHEBI:31429 colforsin daropate hydrochloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005576 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein PMID:12639917 12370161 INS insulin gene CHEBI:37537 phorbol 13-acetate 12-myristate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013755 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein PMID:12639917 12370161 INS insulin gene CHEBI:3892 corticotropin increases abundance EXP E RGD:6480464 20191114 CTD MESH:D000324 INS protein results in increased abundance of Adrenocorticotropic Hormone PMID:1646414 12370161 INS insulin gene CHEBI:42758 aldehydo-D-glucose decreases abundance EXP E RGD:6480464 20191114 CTD MESH:D005947 INS protein results in decreased abundance of Glucose PMID:1646414 12370161 INS insulin gene CHEBI:42758 aldehydo-D-glucose multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005947 [INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin PMID:1013176|PMID:140932 12370161 INS insulin gene CHEBI:4551 digoxin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004077 [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin PMID:1013176|PMID:140932 12370161 INS insulin gene CHEBI:9937 vasopressin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014667 INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins] PMID:1324617 12370168 ABHD14A abhydrolase domain containing 14A gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of ABHD14A mRNA PMID:22747577 12370207 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of LAMTOR1 mRNA PMID:27255383 12372577 PCOLCE2 procollagen C-endopeptidase enhancer 2 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of PCOLCE2 mRNA PMID:22747577 12372873 DES desmin gene CHEBI:3011 benazepril decreases expression EXP E RGD:6480464 20191114 CTD MESH:C044946 benazepril results in decreased expression of DES mRNA PMID:20137276 12373160 TNF tumor necrosis factor gene CHEBI:132230 marbofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:C080260 marbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF protein PMID:31005593 12373160 TNF tumor necrosis factor gene CHEBI:16412 lipopolysaccharide increases expression EXP E RGD:6480464 20220405 CTD MESH:D008070 Lipopolysaccharides results in increased expression of TNF mRNA PMID:32899721 12373160 TNF tumor necrosis factor gene CHEBI:16412 lipopolysaccharide multiple interactions EXP E RGD:6480464 20220405 CTD MESH:D008070 arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] PMID:32899721 12373160 TNF tumor necrosis factor gene CHEBI:26523 reactive oxygen species increases abundance EXP E RGD:6480464 20191114 CTD MESH:D017382 TNF protein results in increased abundance of Reactive Oxygen Species PMID:14973143 12373160 TNF tumor necrosis factor gene CHEBI:26523 reactive oxygen species multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D017382 manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Vitamin E inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] PMID:14973143 12373160 TNF tumor necrosis factor gene CHEBI:2682 amphotericin B increases expression EXP E RGD:6480464 20191114 CTD MESH:D000666 Amphotericin B results in increased expression of TNF protein PMID:24105867 12373160 TNF tumor necrosis factor gene CHEBI:29866 arsenite(3-) multiple interactions EXP E RGD:6480464 20220405 CTD MESH:C015001 arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] PMID:32899721 12373160 TNF tumor necrosis factor gene CHEBI:33234 vitamin E multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D024502 Vitamin E inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] PMID:14973143 12373160 TNF tumor necrosis factor gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of TNF mRNA PMID:33543323 12373160 TNF tumor necrosis factor gene CHEBI:7719 ochratoxin A increases secretion EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased secretion of TNF protein PMID:33543323 12373160 TNF tumor necrosis factor gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein PMID:24582689 12373359 MAGEF1 MAGE family member F1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of MAGEF1 mRNA PMID:22747577 12373364 ADRA2C adrenoceptor alpha 2C gene CHEBI:3757 clonidine (imino form) increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D003000 ADRA2C protein results in increased susceptibility to Clonidine PMID:16814767 12373364 ADRA2C adrenoceptor alpha 2C gene CHEBI:46631 clonidine increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D003000 ADRA2C protein results in increased susceptibility to Clonidine PMID:16814767 12373364 ADRA2C adrenoceptor alpha 2C gene CHEBI:46632 clonidine (amino form) increases response to substance EXP E RGD:6480464 20191114 CTD MESH:D003000 ADRA2C protein results in increased susceptibility to Clonidine PMID:16814767 12374086 JUN Jun proto-oncogene, AP-1 transcription factor subunit gene CHEBI:26710 sodium chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased expression of JUN protein PMID:23816505 12374086 JUN Jun proto-oncogene, AP-1 transcription factor subunit gene CHEBI:26710 sodium chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012965 pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] PMID:23816505 12374086 JUN Jun proto-oncogene, AP-1 transcription factor subunit gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of JUN mRNA PMID:22747577 12374086 JUN Jun proto-oncogene, AP-1 transcription factor subunit gene CHEBI:90695 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C432165 pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] PMID:23816505 12377502 IGFBP7 insulin like growth factor binding protein 7 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of IGFBP7 mRNA PMID:22747577 12377511 RAB27A RAB27A, member RAS oncogene family gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of RAB27A mRNA PMID:27255383 12377712 SYTL4 synaptotagmin like 4 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SYTL4 mRNA PMID:27255383 12377761 CLDN4 claudin 4 gene CHEBI:15367 all-trans-retinoic acid increases expression EXP E RGD:6480464 20191114 CTD MESH:D014212 Tretinoin results in increased expression of CLDN4 mRNA; Tretinoin results in increased expression of CLDN4 protein PMID:17035595 12377761 CLDN4 claudin 4 gene CHEBI:15367 all-trans-retinoic acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D014212 CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA] PMID:17035595 12377761 CLDN4 claudin 4 gene CHEBI:16199 urea increases expression EXP E RGD:6480464 20191114 CTD MESH:D014508 Urea results in increased expression of CLDN4 protein PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:16240 hydrogen peroxide increases expression EXP E RGD:6480464 20191114 CTD MESH:D006861 Hydrogen Peroxide results in increased expression of CLDN4 protein PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:16240 hydrogen peroxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006861 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein] PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:16856 glutathione multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005978 Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:16899 D-mannitol increases expression EXP E RGD:6480464 20191114 CTD MESH:D008353 Mannitol results in increased expression of CLDN4 protein PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:26710 sodium chloride increases expression EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased expression of CLDN4 protein PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:26710 sodium chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012965 Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:28939 N-acetyl-L-cysteine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000111 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:77986 dibenziodolium multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C007517 diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] PMID:23816505 12377761 CLDN4 claudin 4 gene CHEBI:90695 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C432165 pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] PMID:23816505 12377803 EDN1 endothelin 1 gene CHEBI:28790 serotonin increases activity EXP E RGD:6480464 20191114 CTD MESH:D012701 Serotonin results in increased activity of EDN1 protein PMID:9918753 12377803 EDN1 endothelin 1 gene CHEBI:5000 fenfluramine increases activity EXP E RGD:6480464 20191114 CTD MESH:D005277 Fenfluramine results in increased activity of EDN1 protein PMID:9918753 12377803 EDN1 endothelin 1 gene CHEBI:88212 lead(II) chloride increases secretion EXP E RGD:6480464 20191114 CTD MESH:C029891 lead chloride results in increased secretion of EDN1 protein PMID:15915659 12379440 TSLP thymic stromal lymphopoietin gene CHEBI:15864 luteolin multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D047311 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of TSLP promoter PMID:33763461 12379440 TSLP thymic stromal lymphopoietin gene CHEBI:69478 cannabidiol multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D002185 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of TSLP promoter PMID:33763461 12380597 GATA4 GATA binding protein 4 gene CHEBI:4784 enalapril multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D004656 [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein PMID:18820026 12380597 GATA4 GATA binding protein 4 gene CHEBI:6904 metoprolol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008790 [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein PMID:18820026 12380597 GATA4 GATA binding protein 4 gene CHEBI:87681 ranolazine affects expression EXP E RGD:6480464 20191114 CTD MESH:D000069458 Ranolazine affects the expression of GATA4 protein PMID:18820026 12380597 GATA4 GATA binding protein 4 gene CHEBI:87681 ranolazine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000069458 [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein PMID:18820026 12380628 GOT1 glutamic-oxaloacetic transaminase 1 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of GOT1 protein PMID:19952500 12380628 GOT1 glutamic-oxaloacetic transaminase 1 gene CHEBI:9728 trimethaphan increases expression EXP E RGD:6480464 20191114 CTD MESH:D014294 Trimethaphan results in increased expression of GOT1 protein PMID:6848019 12380902 MPDZ multiple PDZ domain crumbs cell polarity complex component gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of MPDZ mRNA PMID:22747577 12381371 TNS1 tensin 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of TNS1 mRNA PMID:22747577 12383542 DPCD deleted in primary ciliary dyskinesia homolog gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of DPCD mRNA PMID:22747577 12384201 GSTA4 glutathione S-transferase alpha 4 gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of GSTA4 mRNA PMID:19952500 12384201 GSTA4 glutathione S-transferase alpha 4 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of GSTA4 mRNA PMID:22747577 12384201 GSTA4 glutathione S-transferase alpha 4 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of GSTA4 mRNA PMID:19952500 12385838 GMFB glia maturation factor beta gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of GMFB mRNA PMID:22747577 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:16240 hydrogen peroxide increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D006861 Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein PMID:23816505 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:16240 hydrogen peroxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D006861 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] PMID:23816505 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:16856 glutathione multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005978 Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] PMID:23816505 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:17924 D-glucitol increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D013012 Sorbitol results in increased phosphorylation of MAPK3 protein PMID:12639917 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:26710 sodium chloride increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D012965 Sodium Chloride results in increased phosphorylation of MAPK3 protein PMID:23816505 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:26710 sodium chloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D012965 Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] PMID:23816505 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:27563 arsenic atom increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D001151 Arsenic results in increased phosphorylation of MAPK3 protein PMID:29306782 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:28939 N-acetyl-L-cysteine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D000111 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] PMID:23816505 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:30621 diarsenic trioxide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C006632 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein PMID:23236503 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:31429 colforsin daropate hydrochloride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005576 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein PMID:12639917 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:37537 phorbol 13-acetate 12-myristate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013755 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein PMID:12639917 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:47217 arsane increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D001151 Arsenic results in increased phosphorylation of MAPK3 protein PMID:29306782 12388002 MAPK3 mitogen-activated protein kinase 3 gene CHEBI:49900 arsenous acid multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C032793 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein PMID:23236503 12388118 TNFRSF1A TNF receptor superfamily member 1A gene CHEBI:132230 marbofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:C080260 marbofloxacin results in increased expression of TNFRSF1A mRNA; marbofloxacin results in increased expression of TNFRSF1A protein PMID:31005593 12388118 TNFRSF1A TNF receptor superfamily member 1A gene CHEBI:132230 marbofloxacin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C080260 TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA] PMID:31005593 12388118 TNFRSF1A TNF receptor superfamily member 1A gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein PMID:24582689 12388118 TNFRSF1A TNF receptor superfamily member 1A gene CHEBI:7731 ofloxacin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D015242 TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] PMID:24582689 12388250 OXCT1 3-oxoacid CoA-transferase 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of OXCT1 protein PMID:22747577 12388284 VPS13B vacuolar protein sorting 13 homolog B gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS13B mRNA PMID:27255383 12389759 CBY1 chibby 1, beta catenin antagonist gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of CBY1 mRNA PMID:27255383 12391828 SLC22A5 solute carrier family 22 member 5 gene CHEBI:38000 uniconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C092705 uniconazole results in decreased activity of SLC22A5 protein PMID:36669674 12391828 SLC22A5 solute carrier family 22 member 5 gene CHEBI:81781 tebuconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087114 tebuconazole results in decreased activity of SLC22A5 protein PMID:36669674 12391828 SLC22A5 solute carrier family 22 member 5 gene CHEBI:81970 penconazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C087058 penconazole results in decreased activity of SLC22A5 protein PMID:36669674 12391828 SLC22A5 solute carrier family 22 member 5 gene CHEBI:81980 triticonazole decreases activity EXP E RGD:6480464 20230801 CTD MESH:C412303 triticonazole results in decreased activity of SLC22A5 protein PMID:36669674 12391987 BAX BCL2 associated X, apoptosis regulator gene CHEBI:9241 spironolactone decreases expression EXP E RGD:6480464 20191114 CTD MESH:D013148 Spironolactone results in decreased expression of BAX protein PMID:20082611 12392076 BTBD3 BTB domain containing 3 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of BTBD3 mRNA PMID:22747577 12392149 LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of LAMTOR2 mRNA PMID:27255383 12392198 RAB44 RAB44, member RAS oncogene family gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of RAB44 mRNA PMID:22747577 12392574 SEC63 SEC63 homolog, protein translocation regulator gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SEC63 mRNA PMID:27255383 12393596 UQCRC1 ubiquinol-cytochrome c reductase core protein 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of UQCRC1 protein PMID:19952500 12398527 AP2S1 adaptor related protein complex 2 subunit sigma 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of AP2S1 mRNA PMID:27255383 12399007 COPG1 COPI coat complex subunit gamma 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of COPG1 mRNA PMID:27255383 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:10093 yohimbine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D015016 Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:18357 (R)-noradrenaline increases activity EXP E RGD:6480464 20191114 CTD MESH:D009638 Norepinephrine results in increased activity of PIK3CG protein PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:18357 (R)-noradrenaline multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009638 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:26034 phosphatidylinositol 3-phosphate multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C055525 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate] PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:3757 clonidine (imino form) increases activity EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in increased activity of PIK3CG protein PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:3757 clonidine (imino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:46631 clonidine increases activity EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in increased activity of PIK3CG protein PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:46631 clonidine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:46632 clonidine (amino form) increases activity EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in increased activity of PIK3CG protein PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:46632 clonidine (amino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] PMID:15958164 12399201 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma gene CHEBI:65329 LY294002 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein] PMID:15958164 12399632 HEXB hexosaminidase subunit beta gene CHEBI:133151 methyl beta-cyclodextrin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C108732 methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein] PMID:21671308 12399632 HEXB hexosaminidase subunit beta gene CHEBI:199449 YM-254890 multiple interactions EXP E RGD:6480464 20231219 CTD MESH:C475455 YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein] PMID:21671308 12399632 HEXB hexosaminidase subunit beta gene CHEBI:49662 indometacin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D007213 Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] PMID:21671308 12399632 HEXB hexosaminidase subunit beta gene CHEBI:61048 ganglioside GM1 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D005677 G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein] PMID:21334356|PMID:21671308 12399632 HEXB hexosaminidase subunit beta gene CHEBI:6736 melittin increases secretion EXP E RGD:6480464 20191114 CTD MESH:D008555 Melitten results in increased secretion of HEXB protein PMID:21334356 12399632 HEXB hexosaminidase subunit beta gene CHEBI:6736 melittin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D008555 G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein] PMID:21334356 12399632 HEXB hexosaminidase subunit beta gene CHEBI:78496 mastoparan increases secretion EXP E RGD:6480464 20191114 CTD MESH:C037500 mastoparan results in increased secretion of HEXB protein PMID:21671308 12399632 HEXB hexosaminidase subunit beta gene CHEBI:78496 mastoparan multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C037500 G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein] PMID:21671308 12399632 HEXB hexosaminidase subunit beta gene CHEBI:8711 quinacrine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D011796 Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein] PMID:21671308 12400151 VPS52 VPS52 subunit of GARP complex gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS52 mRNA PMID:27255383 12401213 BNIP1 BCL2 interacting protein 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of BNIP1 mRNA PMID:27255383 12402456 CA3 carbonic anhydrase 3 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of CA3 protein PMID:19952500 12403252 GSDMD gasdermin D gene CHEBI:7719 ochratoxin A increases expression EXP E RGD:6480464 20210608 CTD MESH:C025589 ochratoxin A results in increased expression of GSDMD mRNA; ochratoxin A results in increased expression of GSDMD protein PMID:33543323 12403252 GSDMD gasdermin D gene CHEBI:7719 ochratoxin A multiple interactions EXP E RGD:6480464 20210608 CTD MESH:C025589 CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein] PMID:33543323 12404079 IL13 interleukin 13 gene CHEBI:15864 luteolin multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D047311 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] PMID:33763461 12404079 IL13 interleukin 13 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of IL13 mRNA PMID:22747577 12404079 IL13 interleukin 13 gene CHEBI:69478 cannabidiol multiple interactions EXP E RGD:6480464 20211207 CTD MESH:D002185 [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] PMID:33763461 12404196 CDADC1 cytidine and dCMP deaminase domain containing 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of CDADC1 mRNA PMID:22747577 12404336 KCTD19 potassium channel tetramerization domain containing 19 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of KCTD19 mRNA PMID:22747577 12405277 HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 gene CHEBI:16412 lipopolysaccharide increases expression EXP E RGD:6480464 20191114 CTD MESH:D008070 Lipopolysaccharides results in increased expression of HSD11B1 mRNA PMID:21798686 12405277 HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 gene CHEBI:41879 dexamethasone increases expression EXP E RGD:6480464 20191114 CTD MESH:D003907 Dexamethasone results in increased expression of HSD11B1 mRNA PMID:21798686 12405409 CASP12 caspase 12 gene CHEBI:7731 ofloxacin increases expression EXP E RGD:6480464 20191114 CTD MESH:D015242 Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein PMID:24582689 12408957 HTR1B 5-hydroxytryptamine receptor 1B gene CHEBI:3374 capsaicin multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D002211 HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin] PMID:16880765 12409610 AGXT alanine--glyoxylate and serine--pyruvate aminotransferase gene CHEBI:3750 clofibrate decreases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in decreased expression of AGXT protein PMID:19952500 12409610 AGXT alanine--glyoxylate and serine--pyruvate aminotransferase gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of AGXT protein PMID:19952500 12409625 GADD45A growth arrest and DNA damage inducible alpha gene CHEBI:64090 tert-butyl hydroperoxide decreases expression EXP E RGD:6480464 20191114 CTD MESH:D020122 tert-Butylhydroperoxide results in decreased expression of GADD45A protein PMID:14729356 12409625 GADD45A growth arrest and DNA damage inducible alpha gene CHEBI:64090 tert-butyl hydroperoxide increases expression EXP E RGD:6480464 20191114 CTD MESH:D020122 tert-Butylhydroperoxide results in increased expression of GADD45A protein PMID:14729356 12409798 LOC477540 SEC14-like protein 3 gene CHEBI:8069 phenobarbital decreases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in decreased expression of SEC14L3 protein PMID:19952500 12411231 HPS4 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of HPS4 mRNA PMID:27255383 12413958 MIR30A microRNA mir-30a gene CHEBI:17833 gentamycin increases expression EXP E RGD:6480464 20210608 CTD MESH:D005839 Gentamicins results in increased expression of MIR30A mRNA PMID:33290828 12414217 PRKCZ protein kinase C zeta gene CHEBI:10093 yohimbine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D015016 Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:18357 (R)-noradrenaline increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D009638 Norepinephrine results in increased phosphorylation of PRKCZ protein PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:18357 (R)-noradrenaline multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D009638 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:3757 clonidine (imino form) increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in increased phosphorylation of PRKCZ protein PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:3757 clonidine (imino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:46631 clonidine increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in increased phosphorylation of PRKCZ protein PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:46631 clonidine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:46632 clonidine (amino form) increases phosphorylation EXP E RGD:6480464 20191114 CTD MESH:D003000 Clonidine results in increased phosphorylation of PRKCZ protein PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:46632 clonidine (amino form) multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D003000 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] PMID:15958164 12414217 PRKCZ protein kinase C zeta gene CHEBI:65329 LY294002 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] PMID:15958164 12414357 EZR ezrin gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of EZR protein PMID:32991862 12415481 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of HERPUD1 mRNA PMID:22747577 12415572 LRP1 LDL receptor related protein 1 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of LRP1 mRNA PMID:22747577 12416162 TFRC transferrin receptor gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of TFRC mRNA PMID:27255383 12416750 ACP5 acid phosphatase 5, tartrate resistant gene CHEBI:27881 resveratrol multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C059514 Resveratrol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] PMID:21239502 12416923 RAB3IP RAB3A interacting protein gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of RAB3IP mRNA PMID:27255383 12419758 SNX16 sorting nexin 16 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SNX16 mRNA PMID:27255383 12420356 KCNS3 potassium voltage-gated channel modifier subfamily S member 3 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of KCNS3 mRNA PMID:27255383 12420682 KLHL5 kelch like family member 5 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of KLHL5 mRNA PMID:22747577 12421372 LOC102151342 ATP synthase subunit d, mitochondrial-like gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in increased expression of ATP5PD protein PMID:32991862 12421480 KCNH2 potassium voltage-gated channel subfamily H member 2 gene CHEBI:2896 astemizole multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D016589 Astemizole binds to and results in decreased activity of KCNH2 protein PMID:12388285 12421480 KCNH2 potassium voltage-gated channel subfamily H member 2 gene CHEBI:3720 cisapride multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D020117 Cisapride binds to and results in decreased activity of KCNH2 protein PMID:12388285 12421480 KCNH2 potassium voltage-gated channel subfamily H member 2 gene CHEBI:9453 Terfenadine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D016593 Terfenadine binds to and results in decreased activity of KCNH2 protein PMID:12388285 12421480 KCNH2 potassium voltage-gated channel subfamily H member 2 gene CHEBI:95129 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D020117 Cisapride binds to and results in decreased activity of KCNH2 protein PMID:12388285 12422763 PEBP4 phosphatidylethanolamine binding protein 4 gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of PEBP4 mRNA PMID:22747577 12424322 CDH1 cadherin 1 gene CHEBI:138858 Azaspiracid decreases uptake EXP E RGD:6480464 20191114 CTD MESH:C406592 azaspiracid results in decreased uptake of CDH1 protein modified form PMID:20547569 12424596 OCA2 OCA2 melanosomal transmembrane protein gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of OCA2 mRNA PMID:22747577 12425093 NRAS NRAS proto-oncogene, GTPase gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of NRAS mRNA PMID:22747577 12425104 FASLG Fas ligand gene CHEBI:3441 carvedilol decreases expression EXP E RGD:6480464 20191114 CTD MESH:C043211 Carvedilol results in decreased expression of FASLG PMID:12875697 12425628 BCHE butyrylcholinesterase gene CHEBI:136185 VX nerve agent decreases activity EXP E RGD:6480464 20191114 CTD MESH:C009680 VX results in decreased activity of BCHE protein PMID:16915560 12425628 BCHE butyrylcholinesterase gene CHEBI:17941 diisopropyl fluorophosphate decreases activity EXP E RGD:6480464 20191114 CTD MESH:D007531 Isoflurophate results in decreased activity of BCHE protein PMID:4631366 12425628 BCHE butyrylcholinesterase gene CHEBI:196010 Butyrylcholine increases hydrolysis EXP E RGD:6480464 20231003 CTD MESH:C017100 BCHE protein results in increased hydrolysis of butyrylcholine PMID:4631366|PMID:4985882 12425628 BCHE butyrylcholinesterase gene CHEBI:196010 Butyrylcholine multiple interactions EXP E RGD:6480464 20231003 CTD MESH:C017100 Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] PMID:4985882 12425628 BCHE butyrylcholinesterase gene CHEBI:27827 paraoxon decreases activity EXP E RGD:6480464 20191114 CTD MESH:D010261 Paraoxon results in decreased activity of BCHE protein PMID:4631366 12425628 BCHE butyrylcholinesterase gene CHEBI:30336 phosphoryl trichloride decreases activity EXP E RGD:6480464 20191114 CTD MESH:C013196 phosphoryl chloride results in decreased activity of BCHE protein PMID:12641435 12425628 BCHE butyrylcholinesterase gene CHEBI:34690 dichlorvos decreases activity EXP E RGD:6480464 20191114 CTD MESH:D004006 Dichlorvos results in decreased activity of BCHE protein PMID:3627083|PMID:4631366 12425628 BCHE butyrylcholinesterase gene CHEBI:41055 butyrylthiocholine increases hydrolysis EXP E RGD:6480464 20191114 CTD MESH:D002092 BCHE protein results in increased hydrolysis of Butyrylthiocholine PMID:22407886 12425628 BCHE butyrylcholinesterase gene CHEBI:45652 succinylcholine increases hydrolysis EXP E RGD:6480464 20191114 CTD MESH:D013390 BCHE protein results in increased hydrolysis of Succinylcholine PMID:4985882 12425628 BCHE butyrylcholinesterase gene CHEBI:45652 succinylcholine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013390 Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] PMID:4985882 12425628 BCHE butyrylcholinesterase gene CHEBI:75701 sarin decreases activity EXP E RGD:6480464 20191114 CTD MESH:D012524 Sarin results in decreased activity of BCHE protein PMID:16915560 12425628 BCHE butyrylcholinesterase gene CHEBI:9195 Soman decreases activity EXP E RGD:6480464 20191114 CTD MESH:D012999 Soman results in decreased activity of BCHE protein PMID:16915560 12427628 AP2M1 adaptor related protein complex 2 subunit mu 1 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of AP2M1 mRNA PMID:27255383 12428468 UGDH UDP-glucose 6-dehydrogenase gene CHEBI:8069 phenobarbital increases expression EXP E RGD:6480464 20191114 CTD MESH:D010634 Phenobarbital results in increased expression of UGDH protein PMID:19952500 12429250 CYP1A1 cytochrome P450 family 1 subfamily A member 1 gene CHEBI:28119 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D013749 [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein PMID:24389113 12429250 CYP1A1 cytochrome P450 family 1 subfamily A member 1 gene CHEBI:28909 iprodione multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C033148 [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein PMID:24389113 12429250 CYP1A1 cytochrome P450 family 1 subfamily A member 1 gene CHEBI:63933 Aroclor 1254 multiple interactions EXP E RGD:6480464 20191114 CTD MESH:D020111 [Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein PMID:24389113 12429250 CYP1A1 cytochrome P450 family 1 subfamily A member 1 gene CHEBI:77013 beta-naphthoflavone increases activity EXP E RGD:6480464 20191114 CTD MESH:D019324 beta-Naphthoflavone results in increased activity of CYP1A1 protein PMID:3929785 12429250 CYP1A1 cytochrome P450 family 1 subfamily A member 1 gene CHEBI:8434 prochloraz multiple interactions EXP E RGD:6480464 20191114 CTD MESH:C045362 [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein PMID:24389113 12429909 VPS35 VPS35 retromer complex component gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of VPS35 mRNA PMID:27255383 12433672 TCP1 t-complex 1 gene CHEBI:63450 masitinib decreases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in decreased expression of TCP1 protein PMID:22747577 12436414 HSPD1 heat shock protein family D (Hsp60) member 1 gene CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP E RGD:6480464 20210309 CTD MESH:D014527 Uric Acid results in decreased expression of HSPD1 protein PMID:32991862 12436414 HSPD1 heat shock protein family D (Hsp60) member 1 gene CHEBI:3750 clofibrate increases expression EXP E RGD:6480464 20191114 CTD MESH:D002994 Clofibrate results in increased expression of HSPD1 protein PMID:19952500 12436542 SNX7 sorting nexin 7 gene CHEBI:197437 mocetinostat increases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in increased expression of SNX7 mRNA PMID:27255383 13395345 ADRA1D adrenoceptor alpha 1D gene CHEBI:31891 Naftopidil multiple interactions EXP E RGD:6480464 20210114 CTD MESH:C064357 naftopidil binds to and results in decreased activity of ADRA1D protein; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein] PMID:19371927 13395345 ADRA1D adrenoceptor alpha 1D gene CHEBI:8093 phenylephrine multiple interactions EXP E RGD:6480464 20210114 CTD MESH:D010656 BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; Phenylephrine binds to and results in increased activity of ADRA1D protein PMID:19371927 40911580 SCT secretin gene CHEBI:16684 atropine multiple interactions EXP E RGD:6480464 20210119 CTD MESH:D001285 Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] PMID:3562434 40911580 SCT secretin gene CHEBI:17544 hydrogencarbonate increases abundance EXP E RGD:6480464 20210119 CTD MESH:D001639 SCT protein results in increased abundance of Bicarbonates PMID:3562434 40911580 SCT secretin gene CHEBI:17544 hydrogencarbonate multiple interactions EXP E RGD:6480464 20210119 CTD MESH:D001639 [Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates; Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] PMID:3562434 40911580 SCT secretin gene CHEBI:28358 rac-lactic acid decreases abundance EXP E RGD:6480464 20210119 CTD MESH:D019344 SCT protein results in decreased abundance of Lactic Acid PMID:2418308 40911580 SCT secretin gene CHEBI:59219 ceruletide multiple interactions EXP E RGD:6480464 20210119 CTD MESH:D002108 [Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates PMID:3562434 40911580 SCT secretin gene CHEBI:78320 2-hydroxypropanoic acid decreases abundance EXP E RGD:6480464 20210119 CTD MESH:D019344 SCT protein results in decreased abundance of Lactic Acid PMID:2418308 40911580 SCT secretin gene CHEBI:78734 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions EXP E RGD:6480464 20210119 CTD MESH:D001285 Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] PMID:3562434 40919152 SRR serine racemase gene CHEBI:63450 masitinib increases expression EXP E RGD:6480464 20210608 CTD MESH:C526575 masitinib results in increased expression of SRR mRNA PMID:22747577 40924379 STAM2 signal transducing adaptor molecule 2 gene CHEBI:197437 mocetinostat decreases expression EXP E RGD:6480464 20231107 CTD MESH:C523184 mocetinostat results in decreased expression of STAM2 mRNA PMID:27255383