# RGD-PIPELINE: ftp-file-extracts # MODULE: qtls build 2022-10-26 # GENERATED-ON: 2024/10/25 # PURPOSE: information about active Rat qtls extracted from RGD database # CONTACT: rgd.developers@mcw.edu # FORMAT: tab delimited text # NOTES: multiple values in a single column are separated by ';' # ### Apr 1 2011 RATMAP_IDs and RHDB_IDs are discontinued ### Oct 22 2012 fixed export of positional information for mouse qtls (positions on assembly build 38 were exported as positions on assembly 37) ### Oct 23 2012 fixed description of columns for human qtls ### Nov 20 2012 rat: positions on assembly map 3.1 are no longer exported; instead position on assembly 5.0 are exported ### Apr 18 2013 rat: crossed strains are reported in separate columns for easier sorting ### Jul 16 2014 mouse: added generation of file QTLS_MOUSE_B38.txt with positions on assemblies 38 and 37 ### Sep 09 2014 rat: added positions on Rnor_6.0 assembly ### Sep 09 2014 mouse: QTLS_MOUSE_B38.txt discontinued; 4 columns added to QTLS_MOUSE.txt file to accommodate assembly 38 positions ### Jan 08 2016 TRAIT_METHODOLOGY column discontinued; column #16 SUBTRAIT_NAME is now called MEASUREMENT_TYPE ### Jan 11 2016 rat: added columns STRAIN_RGD_ID3 and STRAIN_RGD_SYMBOL3 for qtls that have 3+ crossed strains ### Jun 17 2019 data sorted by RGD ID; files exported into species specific directories ### Oct 26 2022 added generation of positions on rn7 assembly # #COLUMN INFORMATION: # (First 25 columns are in common between rat, mouse and human) # #1 QTL_RGD_ID the RGD_ID of the QTL #2 SPECIES species name #3 QTL_SYMBOL official qtl symbol #4 QTL_NAME current qtl name #5 CHROMOSOME_FROM_REF the chromosome from the original paper #6 LOD maximum LOD score if given in paper #7 P_VALUE p-value for QTL if given in paper #8 VARIANCE variance if given in paper #9 FLANK_1_RGD_ID RGD_ID for flank marker 1, if in paper #10 FLANK_1_SYMBOL symbol for flank marker 1, if in paper #11 FLANK_2_RGD_ID RGD_ID for flank marker 2, if in paper #12 FLANK_2_SYMBOL symbol for flank marker 2, if in paper #13 PEAK_RGD_ID RGD_ID for peak marker, if in paper #14 PEAK_MARKER_SYMBOL symbol for peak marker, if in paper #15 TRAIT_NAME trait created for QTL #16 MEASUREMENT_TYPE measurement type for QTL #17 (UNUSED) #18 PHENOTYPES phenotype ontology annotation #19 ASSOCIATED_DISEASES diseases ontology annotation #20 CURATED_REF_RGD_ID RGD_ID of paper(s) on QTL #21 CURATED_REF_PUBMED_ID PUBMED_ID of paper(s) on QTL #22 CANDIDATE_GENE_RGD_IDS RGD_IDS for genes mentioned by paper author #23 CANDIDATE_GENE_SYMBOLS symbols for genes mentioned by paper author #24 INHERITANCE_TYPE dominant, recessive etc. #25 RELATED_QTLS symbols of related QTLS #26 (UNUSED) #27 5.0_MAP_POS_CHR chromosome for assembly Rnor_5.0 #28 5.0_MAP_POS_START start position for assembly Rnor_5.0 #29 5.0_MAP_POS_STOP stop position for assembly Rnor_5.0 #30 5.0_MAP_POS_METHOD qtl positioning method for assembly Rnor_5.0 #31 3.4_MAP_POS_CHR chromosome for assembly RGSC 3.4 #32 3.4_MAP_POS_START start position for assembly RGSC 3.4 #33 3.4_MAP_POS_STOP stop position for assembly RGSC 3.4 #34 3.4_MAP_POS_METHOD qtl positioning method for assembly RGSC 3.4 #35 CROSS_TYPE strain cross type #36 CROSS_PAIR pairing of strains for cross #37 STRAIN_RGD_ID1 RGD_ID of first strain crossed #38 STRAIN_RGD_ID2 RGD_ID of second strain crossed #39 STRAIN_RGD_SYMBOL1 symbol of first strain crossed #40 STRAIN_RGD_SYMBOL2 symbol of second strain crossed #41 6.0_MAP_POS_CHR chromosome for assembly Rnor_6.0 #42 6.0_MAP_POS_START start position for assembly Rnor_6.0 #43 6.0_MAP_POS_STOP stop position for assembly Rnor_6.0 #44 6.0_MAP_POS_METHOD qtl positioning method for assembly Rnor_6.0 #45 STRAIN_RGD_ID3 RGD_ID of third strain crossed #46 STRAIN_RGD_SYMBOL3 symbol of third strain crossed #47 7.2_MAP_POS_CHR chromosome for assembly mRatBN7.2 #48 7.2_MAP_POS_START start position for assembly mRatBN7.2 #49 7.2_MAP_POS_STOP stop position for assembly mRatBN7.2 #50 7.2_MAP_POS_METHOD qtl positioning method for assembly mRatBN7.2 # QTL_RGD_ID SPECIES QTL_SYMBOL QTL_NAME CHROMOSOME_FROM_REF LOD P_VALUE VARIANCE FLANK_1_RGD_ID FLANK_1_SYMBOL FLANK_2_RGD_ID FLANK_2_SYMBOL PEAK_RGD_ID PEAK_MARKER_SYMBOL TRAIT_NAME MEASUREMENT_TYPE (UNUSED) PHENOTYPES ASSOCIATED_DISEASES CURATED_REF_RGD_ID CURATED_REF_PUBMED_ID CANDIDATE_GENE_RGD_IDS CANDIDATE_GENE_SYMBOLS INHERITANCE_TYPE RELATED_QTLS (UNUSED) 5.0_MAP_POS_CHR 5.0_MAP_POS_START 5.0_MAP_POS_STOP 5.0_MAP_POS_METHOD 3.4_MAP_POS_CHR 3.4_MAP_POS_START 3.4_MAP_POS_STOP 3.4_MAP_POS_METHOD CROSS_TYPE CROSS_PAIR STRAIN_RGD_ID1 STRAIN_RGD_ID2 STRAIN_RGD_SYMBOL1 STRAIN_RGD_SYMBOL2 6.0_MAP_POS_CHR 6.0_MAP_POS_START 6.0_MAP_POS_STOP 6.0_MAP_POS_METHOD STRAIN_RGD_ID3 STRAIN_RGD_SYMBOL3 7.2_MAP_POS_CHR 7.2_MAP_POS_START 7.2_MAP_POS_STOP 7.2_MAP_POS_METHOD 61324 rat Eae5 Experimental allergic encephalomyelitis QTL 5 12 14.0 11051 D12Mit2 34925 D12Rat9 nervous system integrity trait (VT:0010566) percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031;2306769 10640775;19299744 Ean6 (maps to same region);Pia4 (maps to same region) 12 24662983 28287040 1 - by flanking markers 12 20932559 24470522 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 12 22650702 52716770 4 - by one flank marker only 12 19610870 46669029 4 - by one flank marker only 61325 rat Aia5 Adjuvant induced arthritis QTL 5 10 0.01 61274 D10Arb20 61275 D10Arb22 10466 D10Mit1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 625379;61519;61073;629560;69693 11953987;10323205;12571866;10087293 Cari1 (interacts with);Cia3 (maps to same region);Cia5 (interacts with);Eau3 (maps to same region);Pia10 (interacts with);Pia5 (maps to same region) 10 24340447 107484761 1 - by flanking markers 10 24006429 110718848 2 - by one flank and peak markers Congenic DA.F344 Congenic 61114 631282 DA/Bkl DA.F344-(D10Arb20-D10Arb22)/Arb 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers 61326 rat Eae6 Experimental allergic encephalomyelitis QTL 6 1 5.3 34399 D1Mgh9 10951 D1Mit13 34326 D1Mgh21 body mass (VT:0001259) change in body weight (CMO:0002045) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 1 195235368 205649793 1 - by flanking markers 1 176854992 186472032 1 - by flanking markers F2 E3xDA;E3 x DA 60997 61013 DA E3 1 188289244 198656062 1 - by flanking markers 1 172949660 181830018 1 - by flanking markers 61327 rat Eae7 Experimental allergic encephalomyelitis QTL 7 1 5.6 33903 D1Mit7 10674 D1Mgh12 10445 D1Wox25 body mass (VT:0001259) change in body weight (CMO:0002045) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031;61039;2302026 10640775;7537756;14674011 Pia35 (maps to same region) 1 262617194 270717037 1 - by flanking markers 1 240980142 247322277 1 - by flanking markers F2 E3xDA;E3 x DA 60997 61013 DA E3 1 236265430 281265430 5 - by peak with adj size 1 216255568 260522016 5 - by peak with adj size 61328 rat Eae8 Experimental allergic encephalomyelitis QTL 8 19 4.0 11471 D19Mit9 34033 D19Mit5 nervous system integrity trait (VT:0010566) percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031;2302026 10640775;14674011 Pia34 (maps to same region) 19 35435631 48006398 1 - by flanking markers 19 26534809 34998604 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 19 24457627 37140233 1 - by flanking markers 19 24816041 33061905 1 - by flanking markers 61329 rat Eae9 Experimental allergic encephalomyelitis QTL 9 6 3.7 34098 D6Mgh3 35821 D6Rat10 body mass (VT:0001259) change in body weight (CMO:0002045) paresis multiple sclerosis 61031 10640775 6 136507025 156897508 4 - by one flank marker only 6 127683728 147636619 4 - by one flank marker only F2 E3 x DA 60997 61013 DA E3 6 127286494 147991367 4 - by one flank marker only 6 122549046 140994061 4 - by one flank marker only 61330 rat Eau1 Experimental allergic uveoretinitis QTL 1 4 3.0E-4 11173 D4Arb8 34001 D4Mit17 11013 D4Arb7 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation Experimental Autoimmune Uveitis 61073;2293749;2296064;61035;61064 10323205;18281616;18453595;9780220;10331011 3197;3834 Npy;Tcrb Aia2 (interacts with);Aia3 (maps to same region);Cia3 (maps to same region);Iddm2 (maps to same region);Scwia1 (interacts with,maps to same region) 4 135563448 196943890 1 - by flanking markers 4 69183301 134858710 1 - by flanking markers F2 LEWxF344 60999 70509 LEW F344/NRrrc 4 70773471 132455556 1 - by flanking markers 4 70362013 132642728 1 - by flanking markers 61331 rat Eau2 Experimental allergic uveoretinitis QTL 2 12 5.0E-4 41960 D12Arb2 61278 D12Arb5 41960 D12Arb2 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation Experimental Autoimmune Uveitis 61073;2293749;2296064 10323205;18281616;18453595 Cia12 (interacts with);Pia4 (interacts with) 12 12361595 33647566 1 - by flanking markers 12 1 29130348 4 - by one flank marker only F2 LEWxF344 60999 70509 LEW F344/NRrrc 12 10256890 31723732 1 - by flanking markers 12 8525423 28064601 1 - by flanking markers 61332 rat Eau3 Experimental allergic uveoretinitis QTL 3 10 0.004 61279 D10Arb3 33941 D10Mit11 34053 D10Mit3 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation Experimental Autoimmune Uveitis 61073;2293749;2296064;61519 10323205;18281616;18453595 2836;3395;3645;3772;3773;3774;3877;3967;61276;69069;1594396 Hsd17b1;Prkca;Ccl2;Stat3;Stat5a;Stat5b;Tnfaip1;Vtn;Crhr1;Ccl5;Trim25 Aia5 (maps to same region);Cari1 (interacts with);Cia5 (maps to same region);Oia3 (interacts with);Pia10 (interacts with,maps to same region) 10 35428279 46754773 2 - by one flank and peak markers 10 35713452 101848683 1 - by flanking markers F2 LEWxF344 60999 70509 LEW F344/NRrrc 10 35669465 46851407 2 - by one flank and peak markers 10 34490559 45579777 2 - by one flank and peak markers 61333 rat Gluco16 Glucose level QTL 16 4 4.3 1.0E-5 42144 D4Arb13 adipocyte glucose uptake trait (VT:0004185) absolute change in adipocyte glucose uptake (CMO:0000873) abnormal adipocyte glucose uptake Insulin Resistance 61078 9171835 4 1 26838530 5 - by peak with adj size 4 1 25671721 5 - by peak with adj size F2 61096 61097 SHR/NCruk WKY/NCruk 4 1 26803291 5 - by peak with adj size 4 1 30372989 5 - by peak with adj size 61334 rat Gluco17 Glucose level QTL 17 12 6.3 34025 D12Mit8 34439 D12Mgh1 adipocyte glucose uptake trait (VT:0004185) adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874) abnormal adipocyte glucose uptake Insulin Resistance 61078 9171835 dominant 12 1 15941791 4 - by one flank marker only 12 1 12240883 4 - by one flank marker only F2 61096 61097 SHR/NCruk WKY/NCruk 61335 rat Bp20 Blood pressure QTL 20 3 3.0 34316 D3Mgh2 33810 D3Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045 9132270 3 154751731 169801009 1 - by flanking markers 3 143214737 158037866 1 - by flanking markers F2 SHR x BN 60985 61000 BN SHR 3 148348739 163640325 1 - by flanking markers 3 141339236 155617360 1 - by flanking markers 61336 rat Bp21 Blood pressure QTL 21 4 4.6 3197 Npy 33757 D4Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;631223;2306880 9132270;11474180;19126752 3239 Oxtr Bp338 (maps to same region) 4 55539285 144233753 1 - by flanking markers 4 55370202 78038013 1 - by flanking markers F2 SHR x BN 60985 61000 BN SHR 4 55791834 79557856 1 - by flanking markers 4 57114705 78881294 1 - by flanking markers 61337 rat Bp22 Blood pressure QTL 22 8 5.1 33559 D8Mit5 33887 D8Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;61054 9132270;9045857 Bp35 (interacts with);Bp39 (interacts with) 8 33603024 45061597 1 - by flanking markers 8 32203394 45291808 1 - by flanking markers intercross;F2 SHRxBN;SHR x BN 60985 61000 BN SHR 8 33558660 46588570 1 - by flanking markers 8 30848154 42692818 1 - by flanking markers 61338 rat Bp23 Blood pressure QTL 23 16 4.3 33848 D16Mit2 33652 D16Mit5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;2306880 9132270;19126752 Bp339 (maps to same region) 16 4954192 49954192 4 - by one flank marker only 16 4304396 49304396 4 - by one flank marker only intercross;F2 SHRxBN;SHR x BN 60985 61000 BN SHR 16 5013802 50013802 4 - by one flank marker only 16 4227609 49227609 4 - by one flank marker only 61339 rat Bp24 Blood pressure QTL 24 13 0.05 33923 D13Mit1 3554 Ren arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 61046;61057;61043;61037 8567976;7981757;8952608;1363813 Bp11 (maps to same region,interacts with);Bp25 (interacts with);Bp31 (interacts with);Bp5 (maps to same region) 13 14281836 55566812 1 - by flanking markers 13 25430110 46275213 1 - by flanking markers F2 10040 10041 SR/Jr SS/Jr 13 9016742 50513953 1 - by flanking markers 13 5994668 44807491 1 - by flanking markers 61340 rat Bp25 Blood pressure QTL 25 13 4.2 0.004 34371 D13Mgh3 61281 D13M1Mit108 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61047;61057;61043;61046;61037 9271663;7981757;8952608;8567976;1363813 Bp11 (interacts with);Bp24 (interacts with);Bp31 (interacts with);Bp5 (interacts with) 13 44494434 89494434 4 - by one flank marker only 13 35472372 80472372 4 - by one flank marker only F2 SS/Jr x SR/Jr 10040 10041 SR/Jr SS/Jr 13 39372927 84372927 4 - by one flank marker only 13 34535218 79535218 4 - by one flank marker only 61341 rat Bp26 Blood pressure QTL 26 1 60787 D1Wox6 43424 D1Wox10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61048;61060;61040;61050;61051 9336384;8528250;9685318;8094726;9774356 Bp197 (interacts with);Bp28 (interacts with,maps to same region);Bp29 (interacts with);Bp30 (interacts with,maps to same region) 1 138777913 244066407 1 - by flanking markers 1 131956599 220639653 1 - by flanking markers F2 61100 628908 SHR/Ola SHR.BN-(D1Mit3-Igf2)/Ipcv 1 137787261 236763528 1 - by flanking markers 737972 BN/Crl 1 169537671 214537671 4 - by one flank marker only 61342 rat Bp27 Blood pressure QTL 27 1 3.4 6.0E-4 61282 D1M7Mit69 61283 D1Mco2 61284 D1Mco1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61049;61040;68885;2291850 8609235;9685318;11160999;18324438 Bp93 (interacts with);Bp94 (interacts with);Bp95 (interacts with) 1 58687835 77717707 2 - by one flank and peak markers F2 10041 60999 SS/Jr LEW 1 57761301 104391981 1 - by flanking markers 1 56732668 98773277 1 - by flanking markers 61343 rat Bp28 Blood pressure QTL 28 1 62086 Acsm3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61050;61060;628394;61048;61049 8094726;8528250;12215469;9336384;8609235 Bp197 (interacts with);Bp26 (interacts with,maps to same region);Bp29 (maps to same region,interacts with);Bp30 (interacts with) 1 173962319 218962319 5 - by peak with adj size 1 155568068 200568068 5 - by peak with adj size F2 SHRSP x WKY 61010 61103 SHRSP WKY 1 167027868 212027868 5 - by peak with adj size 1 151646613 196646613 5 - by peak with adj size 61344 rat Bp29 Blood pressure QTL 29 1 7.5 34011 D1Mit2 60784 D1Wox29 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61051;628394;61060;61048;61049;61050 9774356;12215469;8528250;9336384;8609235;8094726 Bp160 (interacts with);Bp161 (interacts with);Bp197 (interacts with);Bp26 (interacts with);Bp28 (interacts with,maps to same region);Bp30 (interacts with) 1 86822376 131822376 4 - by one flank marker only 1 124614852 134980526 1 - by flanking markers F2 SHR x WKY 61097 629482 WKY/NCruk WKY.SHR-(D1Wox19-D1Mit2)/Njs 1 85779320 130779320 4 - by one flank marker only 1 78350581 123350581 4 - by one flank marker only 61345 rat Rf1 Renal disease susceptibility QTL 1 1 8.9 33571 D1Mit6 10674 D1Mgh12 urine protein amount (VT:0005160) urine protein excretion rate (CMO:0000759) glomerulosclerosis;increased urine protein level end stage renal disease 61060;61090;1299961;1359045;625641;1582571;1643000;70856 8528250;7704027;15060005;15976509;11875190;16837819;17413446;11053483 2721;3780;69193;69327;70931;620485;620716;621077;621325;621578;621721 Got1;Slk;Hps1;Arl3;Cpn1;Pi4k2a;Sfxn3;Oga;As3mt;Nolc1;Avpi1 1 225717037 270717037 4 - by one flank marker only 1 202322277 247322277 4 - by one flank marker only (FHH x ACI) x FHH Backcross ACIxFHH;FHH x ACI 10000 10015 ACI/N FHH/Eur 61346 rat Rf2 Renal disease susceptibility QTL 2 1 3.7 34011 D1Mit2 33959 D1Mit3 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulosclerosis;increased urine protein level end stage renal disease 61060;61090;1357409;70856 8528250;7704027;15758045;11053483 1 117692800 162692800 4 - by one flank marker only 1 134980526 146971983 1 - by flanking markers (FHH x ACI) x FHH Backcross ACIxFHH;FHH x ACI 10000 60993 ACI/N FHH 1 111446783 156446783 4 - by one flank marker only 1 99267916 144267916 4 - by one flank marker only 61347 rat Bp197 Blood pressure QTL 197 1 4.2 3118 Mt1-ps1 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 61060;1643000;70856 8528250;17413446;11053483 Bp26 (interacts with);Bp28 (interacts with);Bp29 (interacts with);Bp30 (interacts with) 1 182441645 227441645 5 - by peak with adj size 1 163190108 208190108 5 - by peak with adj size (FHH x ACI) x FHH Backcross FHH x ACI 10000 60993 ACI/N FHH 1 175462885 220462885 5 - by peak with adj size 1 158633083 203633083 5 - by peak with adj size 61348 rat Bp30 Blood pressure QTL 30 1 2.4 2870 Igf2 42061 D1Arb15 62086 Acsm3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61049;61040;619643;61060;68885;2291850;628394;61048;61050 8609235;9685318;10523340;8528250;11160999;18324438;12215469;9336384;8094726 62086 Acsm3 Bp197 (interacts with);Bp26 (maps to same region,interacts with);Bp28 (interacts with);Bp29 (interacts with);Bp88 (maps to same region);Bp93 (interacts with);Bp94 (interacts with);Bp95 (interacts with) 1 160642307 222722921 1 - by flanking markers 1 146714502 202906624 1 - by flanking markers F2 SS/Jr x LEW/NCrLBR 10041 61104 SS/Jr LEW/NCrl 1 154337847 215828102 1 - by flanking markers 1 144017057 197814409 1 - by flanking markers 61349 rat Bp31 Blood pressure QTL 31 13 5.75 33733 D13Mit2 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 61043;61057;61046;61037 8952608;7981757;8567976;1363813 Bp11 (interacts with,maps to same region);Bp24 (interacts with);Bp25 (interacts with);Bp5 (maps to same region,interacts with) 13 47487222 92487222 5 - by peak with adj size 13 39572400 84572400 5 - by peak with adj size F2 SHR x WKY 61000 61103 SHR WKY 13 42508345 87508345 5 - by peak with adj size 13 37374509 82374509 5 - by peak with adj size 61350 rat Bp32 Blood pressure QTL 32 19 0.012 33618 D19Mit7 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61044;61055 7560090;9199194 Bp46 (interacts with) 19 35632220 72914587 5 - by peak with adj size 19 22590859 59218465 5 - by peak with adj size F2 SHR x BN 61098 61099 BXH/Ipcv HXB/Ipcv 19 24818257 62275575 5 - by peak with adj size 19 20483575 57337602 5 - by peak with adj size 61351 rat Bp33 Blood pressure QTL 33 4 0.0018 2901 Il6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61044 7560090 4 1 25597824 5 - by peak with adj size 4 1 22959087 5 - by peak with adj size F2 SHR x BN 61098 61099 BXH/Ipcv HXB/Ipcv 4 1 25545519 5 - by peak with adj size 4 1 27716890 5 - by peak with adj size 61352 rat Bp34 Blood pressure QTL 34 9 5.0 61287 D9Uia6 61288 D9Uia9 2912 Inha arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61053;619653;2302803 9722941;11161799;18854752 Bp333 (maps to same region);Bp334 (interacts with) 9 46637534 83451810 1 - by flanking markers 9 39390033 77170797 1 - by flanking markers F2 SS/Jr x SR/Jr 10040 10041 SR/Jr SS/Jr 9 46952427 83686153 1 - by flanking markers 9 42495343 79271511 1 - by flanking markers 61353 rat Bp35 Blood pressure QTL 35 8 0.001 33559 D8Mit5 34415 D8Mgh6 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61054;61040;61045 9045857;9685318;9132270 Bp22 (interacts with);Bp39 (interacts with) 8 33603024 65467051 1 - by flanking markers 8 32203394 64762616 1 - by flanking markers F2 61106 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv 8 33558660 65717592 1 - by flanking markers 8 30848154 61290444 1 - by flanking markers 61354 rat Pia10 Pristane induced arthritis QTL 10 10 0.01 61274 D10Arb20 61275 D10Arb22 10466 D10Mit1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61519;629569;61073 12209529;10323205 2836;3395;3772;3773;3774;3877;61276;1594396 Hsd17b1;Prkca;Stat3;Stat5a;Stat5b;Tnfaip1;Crhr1;Trim25 Aia5 (interacts with);Cia5 (maps to same region);Eau3 (interacts with,maps to same region);Oia3 (interacts with) 10 24340447 107484761 1 - by flanking markers 10 24006429 110718848 2 - by one flank and peak markers Congenic DA/F344 Congenic 631282 DA.F344-(D10Arb20-D10Arb22)/Arb 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers 61355 rat Bp36 Blood pressure QTL 36 2 2.9 2071 Agtr1b 33943 D2Mit1 61289 D2Mco19 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;61037 9685318;1363813 Bp10 (interacts with) 2 3125162 124879262 1 - by flanking markers 2 3429900 105503269 1 - by flanking markers F2 SS/Jr x LEW 10041 60999 SS/Jr LEW 2 3127638 105149020 1 - by flanking markers 2 5873687 102844969 1 - by flanking markers 61356 rat Bp37 Blood pressure QTL 37 3 3.0 34146 D3Mgh6 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;631223 9685318;11474180 3238 Oxt 3 38749889 83749889 5 - by peak with adj size 3 28022667 73022667 5 - by peak with adj size F2 SS/Jr x LEW 10041 60999 SS/Jr LEW 3 32130997 77130997 5 - by peak with adj size 3 30684642 75684642 5 - by peak with adj size 61357 rat Bp38 Blood pressure QTL 38 7 1.6 0.052 4.8 34395 D7Mgh1 62504 D7Uia3 33648 D7Mit5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;4891049;7421500 9685318;21192272;23814039 3809;628723;735050 Tac3;Nxph4;Rdh16 Bp279 (interacts with);Bp310 (interacts with) 7 48134589 128652785 2 - by one flank and peak markers 7 44698822 125481104 2 - by one flank and peak markers F2 SS/Jr x LEW 10041 61104 SS/Jr LEW/NCrl 7 48118835 128611831 2 - by one flank and peak markers 7 41333674 119109060 2 - by one flank and peak markers 61358 rat Bp39 Blood pressure QTL 39 8 2.0 44436 D8Wox2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;61045;61054 9685318;9132270;9045857 Bp22 (interacts with);Bp35 (interacts with) 8 39705473 84705473 5 - by peak with adj size 8 38902937 83902937 5 - by peak with adj size F2 SS/Jr x LEW 10040 10041 SR/Jr SS/Jr 8 39927901 84927901 5 - by peak with adj size 8 35551938 80551938 5 - by peak with adj size 61359 rat Eaex Experimental allergic encephalomyelitis QTL x 5 3.0 33678 D5Mit10 43924 D5Wox21 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 5 61438645 106438645 4 - by one flank marker only 5 57974567 102974567 4 - by one flank marker only F2 E3 x DA 60997 61013 DA E3 5 56902367 101902367 4 - by one flank marker only 5 55715622 100715622 4 - by one flank marker only 61360 rat Eaey Experimental allergic encephalomyelitis QTL y 18 3.0 34156 D18Mgh1 10648 D18Wox13 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis duration (CMO:0001424) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 18 47731030 61757188 1 - by flanking markers 18 49034213 87265094 4 - by one flank marker only F2 E3 x DA 60997 61013 DA E3 18 48519299 62570427 1 - by flanking markers 18 46988939 60377753 1 - by flanking markers 61362 rat Oia2 Oil induced arthritis QTL 2 4 0.001 34174 D4Mgh7 33778 D4Mit21 34473 D4Mgh10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61087;61068;629560;2300074;1582387;2324629;61067 9600974;9692888;12571866;18606636;16804090;20200546;11001927 Cia13 (maps to same region,interacts with);Cia3 (maps to same region);Ciaa4 (maps to same region);Oia3 (interacts with);Pia7 (maps to same region);RA20_H (maps to syntenic region) 4 200825021 244267149 2 - by one flank and peak markers 4 136668162 181668162 5 - by peak with adj size F2 60997 737657 DA LEW.1AV1 4 136351734 174694858 2 - by one flank and peak markers 4 138503169 173369699 2 - by one flank and peak markers 61363 rat Oia3 Oil induced arthritis QTL 3 10 0.001 11308 D10Wox20 34128 D10Mgh1 34128 D10Mgh1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61087;61068;62404;2300074;1582387;2307198;61073;2306769;61519 9600974;9692888;11230175;18606636;16804090;18540828;10323205;19299744 Ean5 (maps to same region);Eau3 (interacts with);Oia2 (interacts with);Oia4 (maps to same region);Oia5 (maps to same region);Oia6 (maps to same region);Pia10 (interacts with) 10 90085487 112200500 4 - by one flank marker only 10 91455572 110718848 4 - by one flank marker only F2 631595 LEW.1AV1.DA-(D10Rat92-D10Rat135)/Ubc 10 90296897 112626471 4 - by one flank marker only 10 87307617 107211142 4 - by one flank marker only 61364 rat Iddm2 Insulin dependent diabetes mellitus QTL 2 4 11014 D4Mit7 10782 D4Mit8 11014 D4Mit7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 61075;61032;61481;61073 1303251;9530633;10441739;10323205 Eau1 (maps to same region);Iddm1 (interacts with) F2 BB/DP x BB/DR, BB/DP x F344, BB/DP x LEW 10002 10003 BBDP/Rhw BBDR/Rhw 4 79562451 98542106 1 - by flanking markers 4 78885890 102684881 1 - by flanking markers 61365 rat Iddm1 Insulin dependent diabetes mellitus QTL 1 20 3.54 0.001 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased T cell number;increased circulating glucose level type 1 diabetes mellitus 61076;61075 7026724;1303251 Iddm2 (interacts with) F2 BB/DP x BB/DR, BB/DP x F344, BB/DP x LEW 10002 60999 BBDP/Rhw LEW 61366 rat Iddm3 Insulin dependent diabetes mellitus QTL 3 2 4.7 33727 D2Mit14 33763 D2Mit15 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level;obese type 1 diabetes mellitus 61481;61075;2303106 10441739;1303251;19168599 Iddm26 (maps to same region) 2 224018348 269018348 4 - by one flank marker only 2 197256223 242256223 4 - by one flank marker only F2 (F344 +/+,lv/lv x BB/DR lyp/lyp,u/u) x BB/DR lyp/lyp,u/u 10003 70509 BBDR/Rhw F344/NRrrc 2 204585642 249585642 4 - by one flank marker only 2 189599258 234599258 4 - by one flank marker only 61367 rat Iddm4 Insulin dependent diabetes mellitus QTL 4 18 2.33 0.0074 2715 Gnal blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 61077;625443;61075;61035 9571179;8586150;1303251;9780220 Aia2 (interacts with) 18 39561579 84561579 5 - by peak with adj size 18 41165704 86165704 5 - by peak with adj size F2;backcross BB/OKxDA 60997 61107 DA BB/OK 18 40375769 85375769 5 - by peak with adj size 18 38192455 83192455 5 - by peak with adj size 61368 rat Mcs1 Mammary carcinoma susceptibility QTL 1 2 4.4 33822 D2Mit29 61291 D2Uwm15 35901 D2Rat3 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61080;61081;2291885 8168109;9584103;18057545 2 5396621 40863012 1 - by flanking markers 2 5601528 22318848 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 2 5417336 21657459 1 - by flanking markers 2 7887772 23319447 1 - by flanking markers 61369 rat Mcs2 Mammary carcinoma susceptibility QTL 2 7 3.38 34166 D7Mgh15 61292 D7Uwm9 34051 D7Mit28 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61081;2291885;5133689 9584103;18057545;21625632 Mcs6 (sub_region) 7 24887102 40471913 1 - by flanking markers 7 21161002 38377911 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 7 24738680 40433335 1 - by flanking markers 7 19032807 35526300 1 - by flanking markers 61370 rat Mcs3 Mammary carcinoma susceptibility QTL 3 1 2.15 33686 D1Mit11 34011 D1Mit2 60787 D1Wox6 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61081;2291885 9584103;18057545 1 109100679 168455345 2 - by one flank and peak markers 1 102532145 134980682 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 1 108057233 167517487 2 - by one flank and peak markers 1 102268556 147268556 4 - by one flank marker only 61371 rat Edpm1 Estrogen-dependent pituitary mass QTL 1 2 4.0 0.05 9.6 34425 D2Mgh1 33553 D2Mit7 33824 D2Mit4 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 additive 2 53216438 110970864 2 - by one flank and peak markers 2 34914943 79914943 4 - by one flank marker only intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 2 34088175 91101903 2 - by one flank and peak markers 2 35134841 88029593 2 - by one flank and peak markers 61372 rat Bp40 Blood pressure QTL 40 16 2.2 11448 D16Wox11 33848 D16Mit2 11448 D16Wox11 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040 9685318 16 5038806 19256512 1 - by flanking markers 16 4304517 18121285 1 - by flanking markers F2 SS/Jr x LEW 10041 60999 SS/Jr LEW 16 5098704 19398181 1 - by flanking markers 16 4227730 17696785 1 - by flanking markers 61373 rat Mcs4 Mammary carcinoma susceptibility QTL 4 8 1.1 10437 D8Mgh13 34415 D8Mgh6 10437 D8Mgh13 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61081;737837;2291885 9584103;18057545 2458;2459 Cyp1a1;Cyp1a2 8 20467051 65467051 4 - by one flank marker only 8 61443447 64762616 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 8 20717592 65717592 4 - by one flank marker only 8 16290444 61290444 4 - by one flank marker only 61374 rat Edpm2 Estrogen-dependent pituitary mass QTL 2 2 4.42 0.86 9.2 33620 D2Mit6 34461 D2Mgh12 34114 D2Mgh15 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 2 98037122 235592880 1 - by flanking markers 2 77630629 210636169 1 - by flanking markers intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 2 78321410 217498710 1 - by flanking markers 2 76539322 202447032 1 - by flanking markers 61375 rat Bp41 Blood pressure QTL 41 18 2.4 61294 D18Mco3 11461 D18Mit1 33766 D18Mit4 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;61036 9685318;1655275 Bp2 (maps to same region) 18 15314271 29235489 1 - by flanking markers 18 29344142 80277631 1 - by flanking markers F2 SS/Jr x SR/Jr 10040 10041 SR/Jr SS/Jr 18 15539671 29530300 1 - by flanking markers 18 11944299 41122201 2 - by one flank and peak markers 61376 rat Bp42 Blood pressure QTL 42 1 23.4 2870 Igf2 10674 D1Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055;1626643 9199194;16700878 Bp306 (maps to same region) 1 222722921 270717037 1 - by flanking markers 1 202906624 247322277 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 1 215828102 260828102 4 - by one flank marker only 1 197814409 242814409 4 - by one flank marker only 61377 rat Edpm3 Estrogen-dependent pituitary mass QTL 3 3 7.05 0.038 16.6 10293 D3Mit7 34146 D3Mgh6 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074;1581610 9337394;16416090 additive 3 61249938 100057451 1 - by flanking markers 3 50522717 88648420 1 - by flanking markers intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 3 54631046 93415673 1 - by flanking markers 3 53184692 89878207 1 - by flanking markers 61378 rat Bp43 Blood pressure QTL 43 1 22.6 3750 Spn 3643 Sct arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 1 205563659 221191992 1 - by flanking markers 1 186388120 201472944 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 1 198572999 214277437 1 - by flanking markers 1 181746937 196383668 1 - by flanking markers 61379 rat Bp44 Blood pressure QTL 44 1 19.2 62086 Acsm3 33959 D1Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 1 162692800 196449042 1 - by flanking markers 1 146971983 178054386 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 1 156446783 189514504 1 - by flanking markers 1 144267916 174133260 1 - by flanking markers 61380 rat Edpm5 Estrogen-dependent pituitary mass QTL 5 5 4.5 0.92 9.4 34216 D5Mgh6 34041 D5Mit5 33985 D5Mit11 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent;Pituitary Neoplasms 61074;1300042 9337394;15166088 additive 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 61381 rat Bp45 Blood pressure QTL 45 10 23.2 3385 Ppy 61296 Aoc1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 61382 rat Bp46 Blood pressure QTL 46 18 18.8 3916 Ttr 2741 Nr3c1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055;61036 9199194;1655275 Bp2 (interacts with,maps to same region);Bp32 (interacts with) 18 15307563 32348480 1 - by flanking markers 18 12406571 32459145 1 - by flanking markers intercross;F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 18 15532963 32704022 1 - by flanking markers 18 11941791 31393320 1 - by flanking markers 61383 rat Bp47 Blood pressure QTL 47 18 17.3 2741 Nr3c1 10647 D18Wox12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 18 31408742 61757190 1 - by flanking markers 18 32371496 62660224 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 18 31728373 62570429 1 - by flanking markers 18 31271681 60377755 1 - by flanking markers 61384 rat Bp48 Blood pressure QTL 48 18 19.4 2715 Gnal 33814 D18Mit9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 18 61991738 79748387 1 - by flanking markers 18 63595606 80370517 1 - by flanking markers intercross;F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 18 62805406 80696375 1 - by flanking markers 18 60622311 77209844 1 - by flanking markers 61385 rat Edpm9 Estrogen-dependent pituitary mass QTL 9 9 3.43 0.05 6.5 34088 D9Mgh2 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 additive 9 69971937 114971937 5 - by peak with adj size 9 61932939 106932939 5 - by peak with adj size intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 9 70241351 115241351 5 - by peak with adj size 9 63869687 108869687 5 - by peak with adj size 61386 rat Bp49 Blood pressure QTL 49 5 16.6 33836 D5Mit9 43930 D5Wox4 3193 Nppa cerebrum integrity trait (VT:0010549) brain infarction volume (CMO:0001013) increased cerebral infarct size;increased systemic arterial blood pressure brain infarction;hypertension 61056;1553895 9241273;15454664 3193 Nppa 5 66128197 106340276 1 - by flanking markers 5 62555131 103059258 1 - by flanking markers F2 SHRSP x WKY 61010 61103 SHRSP WKY 5 61612600 102331727 1 - by flanking markers 5 60293434 98603051 1 - by flanking markers 61387 rat Bp1 Blood pressure QTL 1 10 5.1 33941 D10Mit11 3138 Myh3 2686 Gh1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61036;2312779 1655275;15800376 2493 Ace Bp133 (maps to same region);Bp134 (maps to same region) 10 53372408 112200500 2 - by one flank and peak markers 10 53800677 101848470 1 - by flanking markers intercross;F2 SHRSPxWKY 61010 61103 SHRSP WKY 10 53621375 112626471 2 - by one flank and peak markers 10 51770177 107211142 2 - by one flank and peak markers 61388 rat Bp2 Blood pressure QTL 2 18 3.23 33971 D18Mit7 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 61036;61055 1655275;9199194 Bp41 (maps to same region);Bp46 (maps to same region,interacts with) 18 1 34885573 5 - by peak with adj size 18 1 35739743 5 - by peak with adj size F2 SHRSPxWKY 61010 61103 SHRSP WKY 18 1 35097280 5 - by peak with adj size 18 1 35374722 5 - by peak with adj size 61389 rat Bp3 Blood pressure QTL 3 X 1.0E-4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61052 1656270 F2 SHRSP x WKY 61010 61103 SHRSP WKY 61390 rat Bp4 Blood pressure QTL 4 10 19.0 1.0E-4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61052 1656270 F2 SHRSP x WKY 61010 61103 SHRSP WKY 61391 rat Bp5 Blood pressure QTL 5 13 5.6 3554 Ren arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure;increased systemic arterial diastolic blood pressure hypertension 61057;61043;61046;61037 7981757;8952608;8567976;1363813 Bp11 (interacts with,maps to same region);Bp24 (maps to same region);Bp25 (interacts with);Bp31 (maps to same region,interacts with) 13 33061197 78061197 5 - by peak with adj size 13 23769074 68769074 5 - by peak with adj size F2 LH x LN 10021 10022 LH/Mav LN/Mav 13 28008338 73008338 5 - by peak with adj size 13 22301875 67301875 5 - by peak with adj size 61392 rat Bp6 Blood pressure QTL 6 2 7.0 2391 Cpb1 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) increased pulse pressure;increased systemic arterial blood pressure hypertension 61057;68910 7981757;10642295 Bp13 (maps to same region) 2 102319298 147319298 5 - by peak with adj size 2 82928622 127928622 5 - by peak with adj size F2 LH x LN 10021 10022 LH/Mav LN/Mav 2 82574487 127574487 5 - by peak with adj size 2 80270434 125270434 5 - by peak with adj size 61393 rat Bp7 Blood pressure QTL 7 5 4.5 1.0E-4 33836 D5Mit9 61299 D5Mco10 2533 Edn2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61059;61040;619653 8201007;9685318;11161799 2533 Edn2 5 66128197 171686754 1 - by flanking markers 5 62555131 168174140 1 - by flanking markers F2 SS/Jr x LEW 10041 61104 SS/Jr LEW/NCrl 5 61612600 168109659 1 - by flanking markers 5 60293434 161481680 1 - by flanking markers 61394 rat Bp8 Blood pressure QTL 8 17 2.2 8.5 61300 D17Mco3 61301 D17Mco10 10709 D17Mgh3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61059;61040 8201007;9685318 17 24748426 66698782 1 - by flanking markers 17 28967654 70289047 1 - by flanking markers F2 SS/Jr x LEW 10041 61104 SS/Jr LEW/NCrl 17 22775065 64946194 1 - by flanking markers 17 23080567 59555013 1 - by flanking markers 61395 rat Nka1 Natural killer alloreactivity QTL 1 4 natural killer cell cytolysis trait (VT:0005070) lymph node-specific lymphocyte tracer radioactivity level to kidney-specific lymphocyte tracer radioactivity level ratio (CMO:0001870) impaired natural killer cell mediated cytotoxicity autoimmune disease 61084;61085 9521051;8642329 60997 61006 DA PVG 61396 rat Bp9 Blood pressure QTL 9 10 4.8 1.0E-4 2493 Ace arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;61039;70857 1363813;7537756;9299556 2493 Ace 10 71443594 112200500 5 - by peak with adj size 10 72871396 110718848 5 - by peak with adj size F2 SS/Jr x MNS, LEW x SS/Jr, WKY x SS/Jr 10041 60992 SS/Jr MNS 10 71692298 112626471 5 - by peak with adj size 10 68420376 107211142 5 - by peak with adj size 61397 rat Bw17 Body weight QTL 17 7 6.3 24.0 10935 D7Wox14 10427 D7Wox19 10431 D7Wox18 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Body Weight Changes 61061;61082 8528248;8528247 Bw19 (maps to same region) 7 103159395 116152012 1 - by flanking markers 7 98955084 113044249 1 - by flanking markers intercross;F2 GK x BN 10017 60985 GK/KyoSwe BN 7 102588256 116249643 1 - by flanking markers 7 93595647 106839474 1 - by flanking markers 61398 rat Bp50 Blood pressure QTL 50 2 4.4 33727 D2Mit14 33763 D2Mit15 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61058 9329963 2 224018348 269018348 4 - by one flank marker only 2 197256223 242256223 4 - by one flank marker only F2 LH x LN 60990 61015 LH/MavRrrc LN/MavRrrc 2 204585642 249585642 4 - by one flank marker only 2 189599258 234599258 4 - by one flank marker only 61399 rat Tcat1 Tongue tumor resistance QTL 1 1 3.3 34037 D1Mit1 33959 D1Mit3 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879) decreased tongue tumor incidence Tongue Neoplasms 61091 9563479 1 117692800 162692800 4 - by one flank marker only 1 101971983 146971983 4 - by one flank marker only F1 DA/Slc x WF 61007 61111 WF DA/Slc 1 111446783 156446783 4 - by one flank marker only 1 99267916 144267916 4 - by one flank marker only 61400 rat Niddm1 Non-insulin dependent diabetes mellitus QTL 1 1 11.0 33945 D1Mit18 10805 D1Mgh13 33903 D1Mit7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance;increased body weight type 2 diabetes mellitus 61082;619689;2312611;61061 8528247;10720472;19697080;8528248 Bw83 (maps to same region);Gluco51 (maps to same region);Niddm7 (maps to same region) 1 246118980 274224361 1 - by flanking markers 1 224426266 252340527 1 - by flanking markers intercross;F2 GKxF344;GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 1 238830408 266793958 1 - by flanking markers 1 218753689 245907899 1 - by flanking markers 61401 rat Niddm2 Non-insulin dependent diabetes mellitus QTL 2 2 4.54 33763 D2Mit15 33727 D2Mit14 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance;increased circulating glucose level type 2 diabetes mellitus 61082;61061 8528247;8528248 Niddm8 (maps to same region) 2 179018437 224018437 4 - by one flank marker only 2 152256313 197256313 4 - by one flank marker only F2;intercross GKxF344;GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 2 159585731 204585731 4 - by one flank marker only 2 144599348 189599348 4 - by one flank marker only 61402 rat Niddm3 Non-insulin dependent diabetes mellitus QTL 3 10 4.58 34274 D10Mgh5 34445 D10Mgh6 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance;increased circulating glucose level type 2 diabetes mellitus 61082 8528247 10 63366218 85302342 1 - by flanking markers 10 67678060 86316831 1 - by flanking markers F2;intercross GKxF344;GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 10 64648311 85513822 1 - by flanking markers 10 61345413 82564856 1 - by flanking markers 61403 rat Niddm4 Non-insulin dependent diabetes mellitus QTL 4 1 11060 D1Wox23 33903 D1Mit7 43424 D1Wox10 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) abnormal pancreatic islet morphology;increased body weight type 2 diabetes mellitus 61083 9169130 1 232642738 262617374 1 - by flanking markers 1 212121314 240980321 1 - by flanking markers F2 13M x WKY;13MxWKY 61103 61112 WKY 13M 1 225689973 247836969 2 - by one flank and peak markers 1 206329708 222745518 2 - by one flank and peak markers 61404 rat Bw120 Body weight QTL 120 12 5.1 33961 D12Mit5 34373 D12Mgh6 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body weight;increased circulating glucose level type 2 diabetes mellitus 61083;61021;2312611 9169130;10051320;19697080 Bw88 (maps to same region) 12 16444048 54450796 4 - by one flank marker only 12 12770194 42387195 1 - by flanking markers F2 13M x WKY;13MxWKY 61103 61112 WKY 13M 12 14419775 52716770 4 - by one flank marker only 12 12351619 46669029 4 - by one flank marker only 61405 rat Niddm6 Non-insulin dependent diabetes mellitus QTL 6 16 3.66 0.001 33848 D16Mit2 43072 D16Rat116 33848 D16Mit2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 2 diabetes mellitus 61083;61021 9169130;10051320 16 4954192 51871168 1 - by flanking markers 16 4304396 52304351 1 - by flanking markers F2 13M x WKY;13MxWKY 61103 61112 WKY 13M 16 5013802 52144919 1 - by flanking markers 16 4227609 48972724 1 - by flanking markers 61406 rat Scwia1 Streptococcal cell wall induced arthritis QTL 1 4 2.3 42168 D4Arb30 10266 D4Arb4 61302 D4Arb24 joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint swelling Experimental Arthritis 61064;2307198;61073 10331011;18540828;10323205 3197;3834 Npy;Tcrb Aia3 (maps to same region);Cia3 (maps to same region);Eau1 (interacts with,maps to same region) 4 171606455 216606455 4 - by one flank marker only 4 73972453 154937227 1 - by flanking markers F2 LEWxF344 60999 70509 LEW F344/NRrrc 4 105682594 150682594 4 - by one flank marker only 4 106805662 151805662 4 - by one flank marker only 61407 rat Scl12 Serum cholesterol level QTL 12 19 0.001 2571 Ces1c 2535 Ednra 33802 D19Mit2 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating HDL cholesterol level familial hyperlipidemia 61079 8698878 19 26391608 44874904 1 - by flanking markers 19 14981499 32108153 1 - by flanking markers F2 SHR/OlaxBN-lx;SHR/Ola x BN-lx 61100 61113 SHR/Ola BN-Lx 19 15294524 33991703 1 - by flanking markers 19 13926401 30303727 1 - by flanking markers 61408 rat Scl23 Serum cholesterol level QTL 23 4 5.0E-4 2901 Il6 blood HDL phospholipid amount (VT:0010504) serum high density lipoprotein phospholipid level (CMO:0001567) increased circulating HDL cholesterol level familial hyperlipidemia 61079 8698878 4 1 25597824 5 - by peak with adj size 4 1 22959087 5 - by peak with adj size F2 SHR/Ola x BN-lx 61100 61113 SHR/Ola BN-Lx 4 1 25545519 5 - by peak with adj size 4 1 27716890 5 - by peak with adj size 61409 rat Scl13 Serum cholesterol level QTL 13 20 3.5E-4 61303 D20Utr1 blood HDL phospholipid amount (VT:0010504) serum high density lipoprotein phospholipid level (CMO:0001567) increased circulating HDL cholesterol level familial hyperlipidemia 61079 8698878 F2 SHR/Ola x BN-lx 61100 61113 SHR/Ola BN-Lx 61410 rat Bw19 Body weight QTL 19 7 6.2 0.001 10764 D7Mit23 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Body Weight Changes 61082 8528247 2868 Igf1 Bw17 (maps to same region) 7 6027519 51027519 5 - by peak with adj size 7 2030948 47030948 5 - by peak with adj size F2 GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 7 5911477 50911477 5 - by peak with adj size 7 1 44782185 5 - by peak with adj size 61411 rat Pia1 Pristane induced arthritis QTL 1 20 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61088;61089;2300074;1582387;61031;61035;69708 8909256;9843218;18606636;16804090;10640775;9780220;10732705 Aia1 (interacts with);Coreg1 (maps to same region);Eae1 (maps to same region);Pia21 (maps to same region) intercross 60997 61013 DA E3 61412 rat Pia2 Pristane induced arthritis QTL 2 4 3.9 34200 D4Mgh1 35260 D4Rat22 34716 D4Mgh14 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) joint swelling Experimental Arthritis 61089;2307198;2300074;1582387;61031;61035 9843218;18540828;18606636;16804090;10640775;9780220 dominant Aia2 (maps to same region);Eae11 (maps to same region) 4 18184531 60769885 1 - by flanking markers 4 17617956 60974511 1 - by flanking markers F2;intercross E3 x DA 60997 61013 DA E3 4 18222187 61039065 1 - by flanking markers 4 21333343 62278020 1 - by flanking markers 61413 rat Eae10 Experimental allergic encephalomyelitis QTL 10 14 3.5 33551 D14Mit6 10135 D14Wox11 nervous system integrity trait (VT:0010566) percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 Pia6 (maps to same region) 14 19098434 19816468 1 - by flanking markers 14 19142085 19800225 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 14 19191664 19909740 1 - by flanking markers 14 17622685 18274498 1 - by flanking markers 61414 rat Pia3 Pristane induced arthritis QTL 3 6 4.5 33662 D6Mit1 36057 D6Rat4 44173 D6Wox5 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) joint swelling Experimental Arthritis 61089;728382;2307198;2300074;1582387 9843218;14611807;18540828;18606636;16804090 dominant 6 108684958 153719145 1 - by flanking markers 6 98840516 144200901 1 - by flanking markers intercross;F2 E3 x DA 60997 61013 DA E3 6 99273921 144792678 1 - by flanking markers 6 94968928 137848904 1 - by flanking markers 61415 rat Eae11 Experimental allergic encephalomyelitis QTL 11 4 2.9 11378 D4Wox30 34716 D4Mgh14 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 Pia2 (maps to same region) 4 33498841 37534268 1 - by flanking markers 4 32648616 36592773 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 4 33637803 37685319 1 - by flanking markers 4 1 39505420 4 - by one flank marker only 61416 rat Pia4 Pristane induced arthritis QTL 4 12 8.4 44950 D12Wox5 35433 D12Rat17 11449 D12Wox14 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 61089;2300074;1582387;2307198;61073;2306769;2302026 9843218;18606636;16804090;18540828;10323205;19299744;14674011 additive Cia12 (maps to same region);Eae5 (maps to same region);Ean6 (maps to same region);Eau2 (interacts with);Pia12 (maps to same region);Pia38 (maps to same region) 12 17721341 37844419 1 - by flanking markers 12 568621 45568621 5 - by peak with adj size F2;intercross E3 x DA;E3xDA 60997 61013 DA E3 12 15714609 35964508 1 - by flanking markers 12 13635523 30827399 1 - by flanking markers 61417 rat Cia10 Collagen induced arthritis QTL 10 2 3.4 34461 D2Mgh12 joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint inflammation;joint swelling Experimental Arthritis 61063;61064;61065;2307198;2300074;1582387;2296064 9870869;10331011;10631556;18540828;18606636;16804090;18453595 2297;2310;2902;3205;3952;628704;1598328 Cd2;Cd53;Il6r;Nras;Vcam1;Il12b;Ngf additive Cia7 (interacts with);Eau5 (maps to same region) 2 213092797 258092797 5 - by peak with adj size 2 188136088 233136088 5 - by peak with adj size F2 DA/Bkl x ACI 10000 61114 ACI/N DA/Bkl 2 194998627 239998627 5 - by peak with adj size 2 179946951 224946951 5 - by peak with adj size 61418 rat Pia5 Pristane induced arthritis QTL 5 4 4.5 35260 D4Rat22 33933 D4Mit16 10561 D4Wox20 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61089;2307198;2300074;1582387;629560;61062 9843218;18540828;18606636;16804090;12571866;8782824 additive Aia3 (interacts with,maps to same region);Aia5 (maps to same region);Cia3 (interacts with,maps to same region) 4 60769721 192286332 1 - by flanking markers 4 60974346 130228614 1 - by flanking markers F2;intercross E3 x DA 60997 61013 DA E3 4 61038901 127777403 1 - by flanking markers 4 62277855 128289560 1 - by flanking markers 61419 rat Cia11 Collagen induced arthritis QTL 11 3 5.6 12.1 33862 D3Mit9 34228 D3Mgh5 11261 D3Wox9 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2307198;2300074;1582387 10857786;18540828;18606636;16804090 2237;2726;3439;3632 C5;Gpd2;Ptgs1;Scn2a 3 39535971 109733980 1 - by flanking markers 3 26674018 97524000 1 - by flanking markers F2;intercross DA/Bkl x BN/SsN 61114 61115 DA/Bkl BN/SsN 3 34394121 103141944 1 - by flanking markers 3 30356773 98535386 1 - by flanking markers 61420 rat Pia6 Pristane induced arthritis QTL 6 14 4.9 10622 D14Mgh3 11030 D14Mit4 35342 D14Rat8 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 61089;2300074;1582387;2307198;2298688;61031;2302026 9843218;18606636;16804090;18540828;18612083;10640775;14674011 recessive Eae10 (maps to same region);Gluco38 (maps to same region);Pia39 (maps to same region) 14 20172667 43777078 1 - by flanking markers 14 20165393 45020354 1 - by flanking markers F2;intercross E3 x DA 60997 61013 DA E3 14 20266223 43957628 1 - by flanking markers 14 18631345 42337007 1 - by flanking markers 61421 rat Cia12 Collagen induced arthritis QTL 12 12 4.6 10.2 44950 D12Wox5 41962 D12Arb6 10888 D12Wox10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2300074;1582387;2307198;61073;2302026;1285224 10857786;18606636;16804090;18540828;10323205;14674011;15334486 2621;3282;61306;61307;61308 Flt1;Pdgfa;Hspb1;Ncf1;Flt3 Cia25 (maps to same region);Eau2 (interacts with);Pia38 (maps to same region);Pia4 (maps to same region) 12 17721341 43150909 1 - by flanking markers 12 7148164 36894750 2 - by one flank and peak markers F2 DA/Bkl x BN/SsN 61114 61115 DA/Bkl BN/SsN 12 15714609 41291738 1 - by flanking markers 12 13635523 35682913 1 - by flanking markers 61422 rat Cia13 Collagen induced arthritis QTL 13 4 4.5 34001 D4Mit17 34338 D4Mgh11 33768 D4Mit14 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61067;61066;629560;2307198;2300074;1582387;61087 11001927;10857786;12571866;18540828;18606636;16804090;9600974 Ciaa4 (maps to same region);Oia2 (interacts with,maps to same region);Pia7 (maps to same region) 4 196943742 230565226 1 - by flanking markers 4 134858561 171204531 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 4 132455408 168047091 1 - by flanking markers 4 132642577 167139601 1 - by flanking markers 61423 rat Cia14 Collagen induced arthritis QTL 14 19 3.0 7.3 33951 D19Mit8 61309 D19Arb7 34033 D19Mit5 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2307198;2300074;1582387;2296064 10857786;18540828;18606636;16804090;18453595 Eau8 (maps to same region) 19 37325634 58687052 2 - by one flank and peak markers 19 24304442 45692656 2 - by one flank and peak markers F2 DA/Bkl x BN/SsN 61114 61115 DA/Bkl BN/SsN 19 11303927 47879277 1 - by flanking markers 19 10827970 43544039 1 - by flanking markers 61424 rat Scl1 Serum cholesterol level QTL 1 15 7.7 0.001 16.0 34453 D15Mgh7 2536 Ednrb 34353 D15Mgh2 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 15 22481747 91531979 1 - by flanking markers 15 18710622 87898700 1 - by flanking markers F2;intercross SHRSP/A3 x WKY 61116 631286 SHRSP/A3 WKY/Izm 15 18513913 88036354 1 - by flanking markers 15 16725528 80672115 1 - by flanking markers 61425 rat Cia15 Collagen induced arthritis QTL 15 9 4.6 35695 D9Rat44 42251 D9Arb7 34264 D9Mgh5 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2300074;1582387;2307198;61066 11001927;18606636;16804090;18540828;10857786 Ciaa3 (maps to same region) 9 2813697 47058352 1 - by flanking markers 9 2948882 39821284 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 9 2880977 47375681 1 - by flanking markers 9 5109826 42921101 1 - by flanking markers 61426 rat Scl2 Serum cholesterol level QTL 2 5 7.3 0.001 28.0 34322 D5Mgh10 34443 D5Mgh8 34041 D5Mit5 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 5 65595163 152732057 1 - by flanking markers 5 62098646 149757440 1 - by flanking markers F2;intercross SHRSP/A3 x WKY 61116 631286 SHRSP/A3 WKY/Izm 5 61086525 149030144 1 - by flanking markers 5 59793399 143070159 1 - by flanking markers 61427 rat Cia16 Collagen induced arthritis QTL 16 10 3.2 37464 D10Rat95 35256 D10Rat11 35449 D10Rat49 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2300074;1582387;2307198 11001927;18606636;16804090;18540828 10 5243736 99184250 1 - by flanking markers 10 6380753 100633982 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 10 6429075 99492409 1 - by flanking markers 10 6357896 96121100 1 - by flanking markers 61428 rat Scl3 Serum cholesterol level QTL 3 7 3.2 14.0 38334 D7Rat77 36442 D7Rat20 33729 D7Mit10 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 7 98803811 134543261 1 - by flanking markers 7 95054656 132141292 1 - by flanking markers F2 SHRSP/A3 x WKY 61116 631286 SHRSP/A3 WKY/Izm 7 53200344 98200344 4 - by one flank marker only 7 44867533 89867533 4 - by one flank marker only 61429 rat Cia17 Collagen induced arthritis QTL 17 18 4.6 10689 D18Mit5 41356 D18Rat82 41356 D18Rat82 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 18 32348154 72695235 1 - by flanking markers 18 32458819 73666623 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 18 32670352 73016546 1 - by flanking markers 18 31359408 70263868 1 - by flanking markers 61430 rat Cia18 Collagen induced arthritis QTL 18 X 3.1 45715 DXWox2 43947 DXWox3 45715 DXWox2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 Cia19 (maps to same region) X 16479345 127983061 1 - by flanking markers X 4384157 49384157 5 - by peak with adj size F2 BB/DRxBN 10003 60985 BBDR/Rhw BN X 15688119 127888215 1 - by flanking markers X 14843113 120568734 1 - by flanking markers 61431 rat Cia19 Collagen induced arthritis QTL 19 X 4.4 34192 DXMgh9 43947 DXWox3 34991 DXRat66 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 Cia18 (maps to same region) X 71224072 127983061 1 - by flanking markers X 1 88514313 2 - by one flank and peak markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN X 70352120 127888215 1 - by flanking markers X 65612192 120568734 1 - by flanking markers 61432 rat Cia1 Collagen induced arthritis QTL 1 20 11428 D20Wox3 40318 D20Rat60 11428 D20Wox3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61062;2300074;1582387;2307198;61067;61066;61035;69708 8782824;18606636;16804090;18540828;11001927;10857786;9780220;10732705 Aia1 (interacts with);Ciaa1 (interacts with);Coreg1 (maps to same region) 20 6935875 17237454 1 - by flanking markers 20 3660646 14605852 1 - by flanking markers F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 20 4855475 15050565 1 - by flanking markers 20 3621656 14101050 1 - by flanking markers 61433 rat Cia2 Collagen induced arthritis QTL 2 1 5.0 42083 D1Arb37 10335 D1Arb36 39312 D1Rat212 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61062;61068;2300074;1582387;2307198;61067;2302026 8782824;9692888;18606636;16804090;18540828;11001927;14674011 3852;61310 Tgfbr1;Pkrcg Pia36 (maps to same region) 1 80946391 96008597 1 - by flanking markers 1 33153323 78153323 4 - by one flank marker only F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 1 79689765 94909507 1 - by flanking markers 1 78430754 91209302 1 - by flanking markers 61434 rat Cia3 Collagen induced arthritis QTL 3 4 4.8 10562 D4Arb21 61302 D4Arb24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61062;61068;2300074;1582387;2307198;61073;629560;2306769;61064;61087;61089 8782824;9692888;18606636;16804090;18540828;10323205;12571866;19299744;10331011;9600974;9843218 Aia3 (interacts with,maps to same region);Aia5 (maps to same region);Ean2 (maps to same region);Eau1 (maps to same region);Oia2 (maps to same region);Pia5 (maps to same region,interacts with);Scwia1 (maps to same region) 4 163843971 208843971 4 - by one flank marker only 4 104415843 149415843 4 - by one flank marker only F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 4 99066823 144066823 4 - by one flank marker only 4 103194656 148194656 4 - by one flank marker only 61435 rat Cia4 Collagen induced arthritis QTL 4 7 5.3 10221 D7Arb17 34999 D7Rat44 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis;Experimental Arthritis 61069;61062;61068;1599708;2300074;1582387;2307198;61067 10398805;8782824;9692888;17277140;18606636;16804090;18540828;11001927 2896;3285 Il2rb;Pdgfrb recessive Cia8 (interacts with) 7 67533138 69590450 1 - by flanking markers 7 62224456 66202126 1 - by flanking markers F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 7 67346146 69399731 1 - by flanking markers 7 58113224 62004598 1 - by flanking markers 61436 rat Cia5 Collagen induced arthritis QTL 5 10 4.9 2686 Gh1 61275 D10Arb22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61062;61068;1642451;2300074;1582387;61067;61073;631168;625379;69693;61519 8782824;9692888;17673937;18606636;16804090;11001927;10323205;11003387;11953987;10087293 3395;61312 Prkca;Timp2 Aia5 (interacts with);Cari1 (maps to same region);Cia20 (maps to same region,interacts with);Cia21 (interacts with,maps to same region);Cia22 (interacts with,maps to same region);Cia23 (interacts with,maps to same region);Eau3 (maps to same region);Pia10 (maps to same region) 10 94237414 107484761 1 - by flanking markers 10 95692240 110718848 4 - by one flank marker only F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 10 94486204 107857673 1 - by flanking markers 10 91228102 104060283 1 - by flanking markers 61437 rat Cia6 Collagen induced arthritis QTL 6 8 34310 D8Mgh4 38898 D8Rat71 34068 D8Mgh11 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;1599708;2307198;2300074;1582387 11001927;17277140;18540828;18606636;16804090 8 88595396 131397435 1 - by flanking markers 8 86627869 127907359 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 8 89058229 132243842 1 - by flanking markers 8 82460758 122812818 1 - by flanking markers 61438 rat Cia7 Collagen induced arthritis QTL 7 2 4.6 1.0E-4 20.0 11156 D2Mit24 33983 D2Mit23 33674 D2Mit17 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis;Experimental Arthritis 61067;61063;2307198;2300074;1582387;1285224 11001927;9870869;18540828;18606636;16804090;15334486 2391 Cpb1 dominant Cia10 (interacts with);Cia26 (interacts with) 2 84360871 166931968 1 - by flanking markers 2 59700886 146659672 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 2 60325352 147522851 1 - by flanking markers 2 59324377 141596857 1 - by flanking markers 61439 rat Cia8 Collagen induced arthritis QTL 8 7 5.1 36422 D7Rat26 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61069;2307198 10398805;18540828 Cia4 (interacts with) F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 7 32572942 77572942 5 - by peak with adj size 61440 rat Cia9 Collagen induced arthritis QTL 9 Y joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint inflammation;joint swelling Experimental Arthritis 61064;61065;61063 10331011;10631556;9870869 F2 DA/Bkl x ACI 10000 61114 ACI/N DA/Bkl 61441 rat Btemp1 Thermal response to stress QTL 1 10 4.0 52.0 33846 D10Mit2 33909 D10Mit4 3138 Myh3 body temperature trait (VT:0005535) core body temperature (CMO:0001036) increased body temperature;increased response to stress-induced hyperthermia Body Temperature Changes 61094 10679499 10 36354916 65628115 1 - by flanking markers 10 36650094 64860949 1 - by flanking markers SHR/Ola x BN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 10 36584560 66015527 1 - by flanking markers 10 35392457 63642539 1 - by flanking markers 61442 rat Strs1 Sensitivity to stroke QTL 1 1 7.4 33959 D1Mit3 cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) brain ischemia Stroke 61093;2307158;11040448;7411685 8696337;16835352;25084306;23690346 Strs4 (maps to same region) 1 140192506 185192506 5 - by peak with adj size 1 124471914 169471914 5 - by peak with adj size F2 SHRSP x SHR 1581618 7241794 SHRSP/Bbb SHR/Bbb 1 133946489 178946489 5 - by peak with adj size 1 121767634 166767634 5 - by peak with adj size 61443 rat Btemp2 Thermal response to stress QTL 2 12 3.3 9.4E-5 61306 Hspb1 33725 D12Mit1 10878 D12Wox9 body temperature trait (VT:0005535) core body temperature (CMO:0001036) increased body temperature;increased response to stress-induced hyperthermia Body Temperature Changes 61094 10679499 12 19102374 25837102 1 - by flanking markers 12 15508819 21911223 1 - by flanking markers SHR/Ola x BN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 12 17114770 23839390 1 - by flanking markers 12 15025183 20794014 1 - by flanking markers 61444 rat Strs2 Sensitivity to stroke QTL 2 5 4.7 3193 Nppa cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) brain ischemia Stroke 61093;731210 8696337;14678232 Bp155 (maps to same region) 5 145966963 177180328 5 - by peak with adj size 5 142575172 173096209 5 - by peak with adj size F2 SHRSP x SHR 1581618 7241794 SHRSP/Bbb SHR/Bbb 5 142309061 173707219 5 - by peak with adj size 5 135929696 166875058 5 - by peak with adj size 61445 rat Strs3 Sensitivity to stroke QTL 3 4 3.0 10144 D4Mgh16 cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) brain ischemia Stroke 61093 8696337 4 38927545 83927545 5 - by peak with adj size 4 39146794 84146794 5 - by peak with adj size F2 SHRSP x SHR 1581618 7241794 SHRSP/Bbb SHR/Bbb 4 39208222 84208222 5 - by peak with adj size 4 40433388 85433388 5 - by peak with adj size 61446 rat Coreg2 Compensatory renal growth QTL 2 4 3.5 54.0 3371 Pparg 2554 Eno2 61315 D4Cebr7s17 kidney mass (VT:0002707) compensatory renal growth score (CMO:0001894) increased compensatory renal growth kidney disease 61071 10864582 2245 Cacna1c 4 210562928 224311673 1 - by flanking markers 4 151492220 160897723 1 - by flanking markers F2 SHR/Ola x BN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 4 147274055 157294090 1 - by flanking markers 4 148423102 157580971 1 - by flanking markers 61447 rat Tcas1 Tongue tumor susceptibility QTL 1 19 6.08 11471 D19Mit9 tongue integrity trait (VT:0010553) squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875) increased tongue tumor incidence Tongue Neoplasms 61091;1358147 9563479;15876484 2503 Nqo1 Tcas7 (sub_region) 19 12935711 57935711 5 - by peak with adj size 19 4034890 49034890 5 - by peak with adj size F1 DA/Slc x WF 61007 61111 WF DA/Slc 19 1957707 46957707 5 - by peak with adj size 19 2316121 47316121 5 - by peak with adj size 61448 rat Ciaa1 CIA Autoantibody QTL 1 20 30.0 0.001 11206 D20Arb2 61316 D20Arb8 11428 D20Wox3 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) increased IgG level;joint inflammation Experimental Arthritis;Experimental Arthritis 61066;61067;61062;2307198;2300074;1582387;61035 10857786;11001927;8782824;18540828;18606636;16804090;9780220 Aia1 (interacts with,maps to same region);Cia1 (interacts with);Oia1 (maps to same region) 20 5249981 8621883 2 - by one flank and peak markers 20 2790511 4530895 2 - by one flank and peak markers F2 DAxF344, DAxBN, BB/DRxBN 60985 60997 BN DA 20 3151815 6896013 2 - by one flank and peak markers 20 2646395 4597031 2 - by one flank and peak markers 61449 rat Ciaa2 CIA Autoantibody QTL 2 10 7.1 10142 D10Arb9 10641 D10Wox22 10642 D10Mit12 blood autoantibody amount (VT:0003725) calculated serum anti-type 2 collagen antibody titer (CMO:0001279) increased IgG level;joint inflammation Experimental Arthritis;Experimental Arthritis 61518;61066;2300074;1582387;2307198 10857786;18606636;16804090;18540828 2836;3773;3774;3877;1594396 Hsd17b1;Stat5a;Stat5b;Tnfaip1;Trim25 10 66048908 94240491 1 - by flanking markers 10 64308668 95695218 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 10 65590122 110590122 4 - by one flank marker only 10 63221094 107211142 4 - by one flank marker only 61450 rat Ciaa3 CIA Autoantibody QTL 3 9 6.5 44567 D9Wox19 60827 D9Wox23 60827 D9Wox23 blood autoantibody amount (VT:0003725) calculated serum anti-type 2 collagen antibody titer (CMO:0001279) increased IgG level;joint inflammation Experimental Arthritis 61066;61067;2300074;1582387;2307198 10857786;11001927;18606636;16804090;18540828 2232;3951 C3;Vav1 recessive Cia15 (maps to same region) 9 4772291 24554173 1 - by flanking markers 9 18347567 63347567 4 - by one flank marker only F2;intercross (DAxBN)F1 x (BNxDA)F1, and others 60985 60997 BN DA 9 5724254 25692342 1 - by flanking markers 9 7954720 22071169 1 - by flanking markers 61451 rat Ciaa4 CIA Autoantibody QTL 4 4 3.1 34256 D4Mgh18 34338 D4Mgh11 33768 D4Mit14 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) increased IgG level Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 2306;61318;61319;61320;621237 Cd4;Cd69;Tnfrsf7;Kird1;Tnfrsf1a Cia13 (maps to same region);Oia2 (maps to same region) 4 190397443 230565226 1 - by flanking markers 4 128179957 171204531 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 4 125884464 168047091 1 - by flanking markers 4 126395976 167139601 1 - by flanking markers 61452 rat Ciaa5 CIA Autoantibody QTL 5 5 3.5 43928 D5Wox3 34443 D5Mgh8 34220 D5Mgh13 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) increased IgG level Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 2943 Jun 5 101964092 152732057 1 - by flanking markers 5 99080786 149757440 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 5 97921932 149030144 1 - by flanking markers 5 94858972 143070159 1 - by flanking markers 61453 rat Pur1 Proteinuria QTL 1 13 18.06 34371 D13Mgh3 34351 D13Mgh4 urine total protein amount (VT:0000032) urine protein level (CMO:0000591) increased urine protein level proteinuria 619599;2292230 9799838;18064521 Pur16 (sub_region) 13 44494434 47416214 1 - by flanking markers 13 35472372 38489943 1 - by flanking markers (BUF/Mna x WKY/NCrj) x BUF/Mna backcross BUF/Mna x WKY/NCrj 61118 61119 BUF/Mna WKY/NCrlCrlj 13 39372927 42310885 1 - by flanking markers 13 34535218 37415726 1 - by flanking markers 61455 rat Niddm7 Non-insulin dependent diabetes mellitus QTL 7 1 5.5 16.0 43424 D1Wox10 2470 Cyp2c12 43424 D1Wox10 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 61061;619689;2312611 8528248;10720472;19697080 2870;3786 Igf2;Abcc8 Bw83 (maps to same region);Gluco51 (maps to same region);Niddm1 (maps to same region) 1 244066294 266215677 1 - by flanking markers 1 198139596 243139596 5 - by peak with adj size F2;intercross GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 1 236763415 258766873 1 - by flanking markers 1 214537555 238757011 1 - by flanking markers 61457 rat Niddm8 Non-insulin dependent diabetes mellitus QTL 8 2 4.1 0.01 12.0 3336 Pklr 3195 Npr1 11048 D2Wox23 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level type 2 diabetes mellitus 61061;2313613 8528248;19575795 Niddm2 (maps to same region) 2 207865529 209287892 1 - by flanking markers 2 181214853 182740242 1 - by flanking markers F2 GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 2 188449158 189857032 1 - by flanking markers 2 174543008 175950118 1 - by flanking markers 61458 rat Bp10 Blood pressure QTL 10 2 3.42 2167 Atp1a1 2263 Camk2d 2167 Atp1a1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;61038;619639;70380;61045;728179 1363813;8040284;7768551;11773968;9132270;11980293 3195 Npr1 Bp14 (maps to same region,interacts with);Bp16 (maps to same region);Bp19 (interacts with);Bp36 (interacts with);Bp73 (interacts with) 2 223440514 250484590 1 - by flanking markers 2 196657749 224108082 1 - by flanking markers F2 SS/JrxWKY 10041 61103 SS/Jr WKY 2 204003742 231132207 1 - by flanking markers 2 189020722 215287351 1 - by flanking markers 61460 rat Niddm9 Non-insulin dependent diabetes mellitus QTL 9 4 3.4 1.0E-4 10.0 60802 D4Wox3 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level type 2 diabetes mellitus 61061 8528248 F2;intercross GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 61461 rat Bp11 Blood pressure QTL 11 13 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;6892692;61057;61043;61046 1363813;22434847;7981757;8952608;8567976 Bp24 (interacts with,maps to same region);Bp25 (interacts with);Bp31 (interacts with,maps to same region);Bp5 (interacts with,maps to same region) F2 60992 61103 MNS WKY 61462 rat Niddm10 Non-insulin dependent diabetes mellitus QTL 10 5 3.9 0.001 11.0 43870 D5Wox8 34639 D5Pas1 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 61061 8528248 5 4498411 57407155 2 - by one flank and peak markers 5 4291144 49586522 2 - by one flank and peak markers F2;intercross GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 5 4525738 47978104 2 - by one flank and peak markers 5 5112159 47171491 2 - by one flank and peak markers 61463 rat Bp12 Blood pressure QTL 12 10 6.3 1.0E-4 3185 Nos2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;61039;61040 1363813;7537756;9685318 3185 Nos2 10 42940291 87940291 5 - by peak with adj size 10 42554668 87554668 5 - by peak with adj size F2 SS/Jr x LEW, SR/Jr x LEW 10041 60992 SS/Jr MNS 10 43704955 88704955 5 - by peak with adj size 10 41333258 86333258 5 - by peak with adj size 61464 rat Niddm11 Non-insulin dependent diabetes mellitus QTL 11 8 3.1 0.001 10.0 10168 D8Wox5 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level type 2 diabetes mellitus 61061;2312611 8528248;19697080 Insul13 (maps to same region) 8 39734981 84734981 5 - by peak with adj size intercross;F2 GKxBN;GK x BN 10017 60985 GK/KyoSwe BN 8 39958022 84958022 5 - by peak with adj size 8 35582032 80582032 5 - by peak with adj size 61465 rat Bp13 Blood pressure QTL 13 2 3.3 33620 D2Mit6 2391 Cpb1 33620 D2Mit6 blood pressure trait (VT:0000183) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61041;68910 8901842;10642295 Bp132 (maps to same region);Bp6 (maps to same region) 2 98037122 124850792 1 - by flanking markers 2 77630629 105443909 1 - by flanking markers F2;backcross SHRSP x WKY 734759 734760 SHRSP/Gcrc WKY/Gcrc 2 78321410 105089682 1 - by flanking markers 2 76539322 102785628 1 - by flanking markers 61466 rat Niddm12 Non-insulin dependent diabetes mellitus QTL 12 17 3.2 0.001 11.0 10350 D17Wox12 45485 D17Wox9 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased body weight;increased circulating glucose level type 2 diabetes mellitus 61061 8528248 17 62181621 65757413 2 - by one flank and peak markers 17 60586065 71214851 2 - by one flank and peak markers F2;intercorss GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 17 60397177 63994347 2 - by one flank and peak markers 17 54029929 60463637 2 - by one flank and peak markers 61467 rat Bp14 Blood pressure QTL 14 2 2.2 34461 D2Mgh12 34278 D2Mgh14 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61041;631154;1643008;7401270;728179;68910;61045;61038 8901842;12624007;17938382;23648703;11980293;10642295;9132270;8040284 Bp10 (interacts with,maps to same region);Bp132 (maps to same region);Bp16 (interacts with);Bp166 (maps to same region);Bp19 (maps to same region) 2 62179292 235592715 1 - by flanking markers 2 42866342 210636008 1 - by flanking markers F2;backcross SHRSP x WKY 734759 734760 SHRSP/Gcrc WKY/Gcrc 2 43133606 217498545 1 - by flanking markers 2 43154682 202446871 1 - by flanking markers 61468 rat Bp15 Blood pressure QTL 15 3 4.4 34347 D3Mgh16 blood pressure trait (VT:0000183) diastolic blood pressure (CMO:0000005);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61041;1302893 8901842;15452030 recessive 3 1 33861758 5 - by peak with adj size 3 1 28873394 5 - by peak with adj size F2 SHRSP x WKY 734759 734760 SHRSP/Gcrc WKY/Gcrc 3 1 28500807 5 - by peak with adj size 3 1 33278763 5 - by peak with adj size 61469 rat Bp16 Blood pressure QTL 16 2 5.64 60797 D2Wox7 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 61043;61045;728179;619639 8952608;9132270;11980293;7768551 2167 Atp1a1 Bp10 (maps to same region);Bp14 (interacts with);Bp19 (interacts with) 2 204149709 249149709 5 - by peak with adj size 2 177484675 222484675 5 - by peak with adj size F2 SHRxWKY 61000 61103 SHR WKY 2 184730446 229730446 5 - by peak with adj size 2 169745596 214745596 5 - by peak with adj size 61471 rat Bp18 Blood pressure QTL 18 2 3.0 3119 Mt1-ps2 34278 D2Mgh14 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;2306880 9132270;19126752 Bp336 (maps to same region) 4 203187690 248187690 4 - by one flank marker only 2 11261631 42866342 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 61472 rat Aia1 Adjuvant induced arthritis QTL 1 20 18.0 0.001 11206 D20Arb2 61316 D20Arb8 11428 D20Wox3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61035;2307198;2300074;1582387;69708;61066 9780220;18540828;18606636;16804090;10732705;10857786 Cia1 (interacts with);Ciaa1 (interacts with,maps to same region);Coreg1 (maps to same region);Oia1 (interacts with);Pia1 (interacts with) 20 5249981 8621883 2 - by one flank and peak markers 20 2790511 4530895 2 - by one flank and peak markers F2 DAxF344 60997 70509 DA F344/NRrrc 20 3151815 6896013 2 - by one flank and peak markers 20 2646395 4597031 2 - by one flank and peak markers 61473 rat Bp19 Blood pressure QTL 19 2 6.3 34292 D2Mgh8 3195 Npr1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;2306880;70380;728179;619639 9132270;19126752;11773968;11980293;7768551 Bp10 (interacts with);Bp14 (maps to same region);Bp16 (interacts with);Bp337 (maps to same region);Bp73 (interacts with) 2 206015127 209287892 1 - by flanking markers 2 179302449 182740242 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 2 186611811 189857032 1 - by flanking markers 2 172710921 175950118 1 - by flanking markers 61474 rat Eae1 Experimental allergic encephalomyelitis QTL 1 20 3.0 37594 D20Rat41 34280 D20Mgh4 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) paresis Experimental Autoimmune Encephalomyelitis 61031 10640775 Pia1 (maps to same region) 20 6118659 7910747 1 - by flanking markers 20 4740609 6880472 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 20 4039113 5875448 1 - by flanking markers 20 4606607 6691706 1 - by flanking markers 61475 rat Aia2 Adjuvant induced arthritis QTL 2 4 5.8 42158 D4Arb26 42168 D4Arb30 34282 D4Mgh15 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61035;629560;2300074;1582387;2307198 9780220;12571866;18606636;16804090;18540828 Eau1 (interacts with);Iddm4 (interacts with);Pia2 (maps to same region) 4 37534124 72703184 2 - by one flank and peak markers 4 36592628 73972591 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 4 37685175 73066691 2 - by one flank and peak markers 4 39505275 73892441 2 - by one flank and peak markers 61476 rat Aia3 Adjuvant induced arthritis QTL 3 4 3.9 42168 D4Arb30 10158 D4Arb16 61302 D4Arb24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61035;629560;2300074;1582387;2307198;61073;61064;61089;61062 9780220;12571866;18606636;16804090;18540828;10323205;10331011;9843218;8782824 3197;3834 Npy;Tcrb Cia3 (interacts with,maps to same region);Eau1 (maps to same region);Pia5 (maps to same region,interacts with);Scwia1 (maps to same region) 4 151024194 196024194 4 - by one flank marker only 4 73972453 133939659 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 4 86532519 131532519 4 - by one flank marker only 4 86730991 131730991 4 - by one flank marker only 61477 rat Aia4 Adjuvant induced arthritis QTL 4 15 3.0 33820 D15Mit6 34471 D15Mgh3 35230 D15Rat22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61035;2307198;2300074;1582387 9780220;18540828;18606636;16804090 15 66251142 102837144 1 - by flanking markers 15 61458810 99039586 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 15 62596410 99372139 1 - by flanking markers 15 55596089 91365858 1 - by flanking markers 70153 rat Bp59 Blood pressure QTL 59 14 3.2 40852 D14Rat90 41138 D14Rat94 2041 Add1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 2041 Add1 14 73407669 88669930 1 - by flanking markers 14 73956596 89192873 1 - by flanking markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 14 73391467 88870994 1 - by flanking markers 14 68757796 83368335 1 - by flanking markers 70154 rat Insul2 Insulin level QTL 2 20 3.75 33563 D20Mit5 34280 D20Mgh4 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) decreased circulating insulin level type 2 diabetes mellitus 70067;69703 9819774 20 7910747 20898221 1 - by flanking markers 20 6880472 18245770 1 - by flanking markers F2 F344xOLETF 70509 734526 F344/NRrrc OLETF/Got 20 5875448 18739210 1 - by flanking markers 20 6691706 17489458 1 - by flanking markers 70155 rat Gcs1 Gastric cancer susceptibility QTL1 15 3.8 36602 D15Rat29 34357 D15Mgh4 40106 D15Rat102 stomach morphology trait (VT:0000470) stomach tumor susceptibility score (CMO:0002043) increased incidence of induced tumors Stomach Neoplasms 69698 10706129 15 87456591 114627140 2 - by one flank and peak markers 15 83349477 108387242 1 - by flanking markers (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 15 83947714 111246239 2 - by one flank and peak markers 15 76306099 101769107 2 - by one flank and peak markers 70156 rat Niddm30 Non-insulin dependent diabetes mellitus QTL 30 5 3.98 34581 D5Mgh27 34168 D5Mgh22 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance 70067;69696;7207431;2312611 10594234;23118743;19697080 Gluco52 (maps to same region) 5 138292963 160953783 1 - by flanking markers 5 135910738 157584492 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 5 134502140 157212422 1 - by flanking markers 5 129132447 151006154 1 - by flanking markers 70157 rat Niddm32 Non-insulin dependent diabetes mellitus QTL 32 17 4.34 2532 Edn1 34120 D17Mgh5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696 10594234 17 24117499 51171794 1 - by flanking markers 17 28303886 59104944 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 17 22136814 53475276 1 - by flanking markers 17 22454924 50909196 1 - by flanking markers 70158 rat Bp60 Blood pressure QTL 60 20 3.0 38216 D20Rat22 37570 D20Rat38 38762 D20Rat40 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 20 35134762 47429142 1 - by flanking markers 20 30941362 36641808 2 - by one flank and peak markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 20 33354783 45719230 1 - by flanking markers 20 31614284 44396023 1 - by flanking markers 70159 rat Bp61 Blood pressure QTL 61 7 1.0E-4 62494 D7Uia1 33816 D7Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69709;69710;69711;619653 7981756;9383281;11247666;11161799 2453 Cyp11b1 Bp169 (maps to same region) 7 112367543 126236887 1 - by flanking markers 7 108875615 123635849 1 - by flanking markers F2 SxR 10040 10041 SR/Jr SS/Jr 7 112429186 126525386 1 - by flanking markers 7 103146217 116738842 1 - by flanking markers 70160 rat Bw18 Body weight QTL 18 1 5.7 33959 D1Mit3 3643 Sct body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69701;619689 9530625;10720472 Bw83 (maps to same region) 1 162692213 221191992 1 - by flanking markers 1 146971846 201472944 1 - by flanking markers F1xSHR (BB/OKxSHR)F1xSHR 61107 61110 BB/OK SHR/Mol 1 156446196 214277437 1 - by flanking markers 1 144267353 196383668 1 - by flanking markers 70161 rat Bp62 Blood pressure QTL 62 8 2.9 0.001 13.5 33887 D8Mit3 40168 D8Rat133 35014 D8Rat24 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;61516 11015598 dominant 8 45061464 96501839 1 - by flanking markers 8 45291674 94514282 1 - by flanking markers F2;intercross SxSHR;SS/JrxSHR 10041 724574 SS/Jr SHR/NHsd 8 46588437 96998640 1 - by flanking markers 8 42692684 90165460 1 - by flanking markers 70162 rat Bp63 Blood pressure QTL 63 2 5.64 60797 D2Wox7 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 70067;61043 8952608 2 204149709 249149709 5 - by peak with adj size 2 177484675 222484675 5 - by peak with adj size F2 SHRxWKY 61000 61103 SHR WKY 2 184730446 229730446 5 - by peak with adj size 2 169745596 214745596 5 - by peak with adj size 70163 rat Bw20 Body weight QTL 20 1 5.1 62086 Acsm3 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69701 9530625 1 196449042 270717037 1 - by flanking markers 1 178054386 247322277 1 - by flanking markers F1xSHR SHRx(BB/OKxSHR)F1 61107 61110 BB/OK SHR/Mol 1 189514504 234514504 4 - by one flank marker only 1 174133260 219133260 4 - by one flank marker only 70164 rat Bw21 Body weight QTL 21 10 4.36 5.0E-5 11.9 44839 D10Wox7 11479 D10Mit8 3385 Ppy body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69691;625760 9824537;12420133 10 55422144 102101261 1 - by flanking markers 10 55851811 103550924 1 - by flanking markers F2;intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 10 55679084 102427604 1 - by flanking markers 10 53797494 98952626 1 - by flanking markers 70165 rat Bp64 Blood pressure QTL 64 X 5.2 7.2 34559 DXMgh12 35030 DXRat2 36111 DXRat8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69713 9931114 X 2456588 33791311 1 - by flanking markers X 30326177 52447691 2 - by one flank and peak markers F2 SBHxSBN 631572 631573 SBH/Ygl SBN/Ygl X 1662609 33443848 1 - by flanking markers X 1448129 31706553 1 - by flanking markers 70166 rat Bp65 Blood pressure QTL 65 X 5.8 7.5 35030 DXRat2 36474 DXRat4 36474 DXRat4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69713 9931114 X 2456432 13162713 1 - by flanking markers X 994805 45994805 5 - by peak with adj size F2 SBHxSBN 631572 631573 SBH/Ygl SBN/Ygl X 1662453 12370298 1 - by flanking markers X 1447972 11374346 1 - by flanking markers 70167 rat Bw22 Body weight QTL 22 4 3.1 60732 D4Mit6 3753 Spr 11015 D4Mit24 body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69707 9530522 4 141978848 181496612 1 - by flanking markers 4 75732943 119369308 1 - by flanking markers (BB/OKxSHR)F1xBB/OK 61107 61110 BB/OK SHR/Mol 4 77307388 116916073 1 - by flanking markers 4 76647384 117676292 1 - by flanking markers 70168 rat Eae12 Experimental allergic encephalomyelitis QTL 12 10 9.0E-4 34941 D10Rat7 36283 D10Rat15 34100 D10Mgh3 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) abnormal inflammatory response;demyelination;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 10 95243104 103956674 1 - by flanking markers 10 96667338 105886241 1 - by flanking markers F2 DAxACI 10000 60997 ACI/N DA 10 95508221 104329177 1 - by flanking markers 10 92238497 101012337 1 - by flanking markers 70169 rat Eae13 Experimental allergic encephalomyelitis QTL 13 12 0.032 36671 D12Rat19 36025 D12Rat23 36490 D12Rat18 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) demyelination;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 12 29163190 44046371 1 - by flanking markers 12 25367251 37906389 1 - by flanking markers F2 DAxACI 10000 60997 ACI/N DA 12 27190240 42196641 1 - by flanking markers 12 24139202 36638073 1 - by flanking markers 70170 rat Eae14 Experimental allergic encephalomyelitis QTL 14 13 0.0024 36069 D13Rat23 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) abnormal inflammatory response;demyelination;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 13 33639787 78639787 5 - by peak with adj size 13 24701710 69701710 5 - by peak with adj size F2 DAxACI 10000 60997 ACI/N DA 13 28584452 73584452 5 - by peak with adj size 13 23203448 68203448 5 - by peak with adj size 70171 rat Cari1 Carrageenan-induced inflammation QTL 1 10 4.9 5.0E-4 18.0 33941 D10Mit11 11479 D10Mit8 34274 D10Mgh5 hypodermis integrity trait (VT:0010550) inflammatory exudate volume (CMO:0001429) abnormal inflammatory response Acute-Phase Reaction;Inflammation 70067;69693;69694;61073 10087293;9973459;10323205 dominant Aia5 (interacts with);Cia5 (maps to same region);Eau3 (interacts with) 10 55422036 112200500 2 - by one flank and peak markers 10 55851811 101848470 1 - by flanking markers F2 F344xLEW 60999 70509 LEW F344/NRrrc 10 55678976 112626471 2 - by one flank and peak markers 10 53797385 107211142 2 - by one flank and peak markers 70172 rat Eae15 Experimental allergic encephalomyelitis QTL 15 18 0.001 34290 D18Mgh4 33814 D18Mit9 33715 D18Mit6 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) demyelination;increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 18 79012526 79748387 1 - by flanking markers 18 79585008 80370517 1 - by flanking markers F2 DAxACI 10000 60997 ACI/N DA 18 79948616 80696375 1 - by flanking markers 18 76477814 77209844 1 - by flanking markers 70173 rat Niddm19 Non-insulin dependent diabetes mellitus QTL 19 7 4.33 5.0E-5 34132 D7Mgh18 60819 D7Wox3 44295 D7Wox6 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance;impaired glucose tolerance type 2 diabetes mellitus 70067;69691;69696;625760;1643009;7207431;2312611 9824537;10594234;12420133;17710484;23118743;19697080 Gluco53 (maps to same region) 7 71619460 143501887 2 - by one flank and peak markers 7 68162496 143002779 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 1302654 F344.OLETF-(D7Mgh16-D7Mgh20)/Tj 7 71448715 145729302 2 - by one flank and peak markers 7 64002457 135012528 2 - by one flank and peak markers 70174 rat BpQTLCluster2 Blood pressure QTL cluster 2 2 4.24 34397 D2Mgh2 2391 Cpb1 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 2 59248567 124850792 1 - by flanking markers 2 39828973 105443909 1 - by flanking markers F2 LHxLN 60990 61015 LH/MavRrrc LN/MavRrrc 2 40171834 105089682 1 - by flanking markers 2 40067944 102785628 1 - by flanking markers 70175 rat BpQTLCluster3 Blood pressure QTL cluster 3 2 4.128 34461 D2Mgh12 34497 D2Mgh24 arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 2 160041016 235592715 1 - by flanking markers 2 140403692 210636008 1 - by flanking markers F2 SHRxWKY 61000 61103 SHR WKY 2 140566078 217498545 1 - by flanking markers 2 135552573 202446871 1 - by flanking markers 70176 rat Mcsm1 Mammary carcinoma susceptibility modifier QTL 1 6 33993 D6Mit2 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417 11139513 6 71775541 116775541 5 - by peak with adj size 6 61787263 106787263 5 - by peak with adj size 61105 737908 WKY/NHsd WF/NHsd 6 62263348 107263348 5 - by peak with adj size 6 58632962 103632962 5 - by peak with adj size 70177 rat Xhs1 X-ray hypersensitivity QTL 1 4 25.1 41200 D4Rat169 34592 D4Mgh20 36043 D4Rat49 intestine integrity trait (VT:0010554) post-insult time to onset of moribundity (CMO:0001896) increased cellular sensitivity to X-ray irradiation Experimental Radiation Injuries 69702;70067 11003700 4 144032425 219142061 2 - by one flank and peak markers 4 82861630 155893772 2 - by one flank and peak markers (LECxBN)xLEC 68066 634377 LEC BN/Sea 4 81959983 152055009 2 - by one flank and peak markers 4 82798864 152731274 2 - by one flank and peak markers 70178 rat Eaez Experimental allergic encephalomyelitis QTL z 18 2.4 33971 D18Mit7 60774 D18Wox1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) abnormal inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;61031 10640775 18 12385472 14882610 1 - by flanking markers 18 13239641 58239641 4 - by one flank marker only F2;resistant E3 rat x susceptible DA, LOD=2.4 (severity)=2.3 (duration af disease) E3xDA 60997 61013 DA E3 18 12597179 15099007 1 - by flanking markers 18 12357786 12874620 1 - by flanking markers 70179 rat Xhs2 X-ray hypersensitivity QTL 2 1 3.2 37198 D1Rat186 42448 D1Rat392 42449 D1Rat391 intestine integrity trait (VT:0010554) post-insult time to onset of moribundity (CMO:0001896) increased cellular sensitivity to X-ray irradiation Experimental Radiation Injuries 69702;70067 11003700 1 17574243 21618253 1 - by flanking markers 1 15833442 19577925 1 - by flanking markers (LECxBN)xLEC 68066 634377 LEC BN/Sea 1 16033078 20130904 1 - by flanking markers 1 15321100 19121980 1 - by flanking markers 70180 rat BpQTLcluster10 Blood pressure QTL cluster 10 11 3.19 33642 D11Mit1 33700 D11Mit5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70067;68932 10779487 11 39486246 84486246 4 - by one flank marker only 11 35910590 80910590 4 - by one flank marker only F2 SHRxBN 60985 61000 BN SHR 11 35900634 80900634 4 - by one flank marker only 11 34918041 79918041 4 - by one flank marker only 70181 rat BpQTLcluster11 Blood pressure QTL cluster 11 13 6.922 10462 D13Mgh13 34080 D13Mgh10 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932;1625678 10779487;17566075 13 41256240 104953660 1 - by flanking markers 13 52688796 97688796 4 - by one flank marker only F2 SSxBN 60985 69369 BN SS 13 36147533 99968921 1 - by flanking markers 13 31241331 93395974 1 - by flanking markers 70182 rat BpQTLcluster12 Blood pressure QTL cluster 12 15 3.53 34160 D15Mgh5 34222 D15Mgh8 2536 Ednrb arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) increased systemic arterial blood pressure hypertension 70067;68932 10779487 15 84794402 106602088 1 - by flanking markers 15 80362100 102741229 1 - by flanking markers F2 SSxBN 60985 69369 BN SS 15 81255430 103164962 1 - by flanking markers 15 73690657 95018120 1 - by flanking markers 70183 rat BpQTLcluster13 Blood pressure QTL cluster 13 16 3.654 33848 D16Mit2 34066 D16Mgh1 2708 Glud1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 16 4954192 45651269 1 - by flanking markers 16 4304396 46137590 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 16 5013802 45905331 1 - by flanking markers 16 4227609 43025077 1 - by flanking markers 70184 rat BpQTLcluster14 Blood pressure QTL cluster 14 17 3.38 33882 D17Mit2 33654 D17Mit7 2518 Drd1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 17 10820271 35195242 1 - by flanking markers 17 14575011 38353858 1 - by flanking markers F2 FHHxACI 10000 60993 ACI/N FHH 17 1 33303755 2 - by one flank and peak markers 17 1 31990913 2 - by one flank and peak markers 70185 rat BpQTLcluster15 Blood pressure QTL cluster 15 18 4.61 34290 D18Mgh4 34218 D18Mgh2 2060 Adrb2 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in systolic blood pressure (CMO:0000607);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 18 61092546 79012526 1 - by flanking markers 18 62313296 79585008 1 - by flanking markers F2 SSxBN 60985 69369 BN SS 18 61901354 79948616 1 - by flanking markers 18 59712417 76477814 1 - by flanking markers 70186 rat Niddm26 Non-insulin dependent diabetes mellitus QTL 26 9 3.87 44567 D9Wox19 34088 D9Mgh2 36582 D9Rat21 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611 10594234;12420133;23118743;19697080 Gluco54 (maps to same region) 9 24554173 92471992 1 - by flanking markers 9 18347567 84432994 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 9 25692342 92741406 1 - by flanking markers 9 22071169 86369743 1 - by flanking markers 70187 rat Pancm5 Pancreatic morphology QTL 5 14 16.7 35342 D14Rat8 2670 Gck pancreas mass (VT:0010144) pancreas weight to body weight ratio (CMO:0000630) impaired pancreas regeneration type 2 diabetes mellitus 70067;69697;2313613 9745032;19575795 14 32389647 86875295 1 - by flanking markers 14 32584630 86587723 1 - by flanking markers F2 OLETFxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 32593926 86191589 1 - by flanking markers 14 30320092 80829842 1 - by flanking markers 70188 rat BpQTLcluster1 Blood pressure QTL cluster 1 1 4.864 33891 D10Mit5 3710 Slc4a1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 10 21392295 90101181 1 - by flanking markers 10 21607719 91471072 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 10 21523906 90312401 1 - by flanking markers 10 42323132 87323132 4 - by one flank marker only 70189 rat Mcs5 Mammary carcinoma susceptibility QTL 5 5 10.51 34501 D5Mgh26 69569 D5Uwm38 35771 D5Rat22 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885;1601189 11139513;18057545;17404222 5 61525796 141515484 1 - by flanking markers 5 58063971 139156771 1 - by flanking markers 61105 737908 WKY/NHsd WF/NHsd 5 56991667 137729065 1 - by flanking markers 5 55805606 132207589 1 - by flanking markers 70190 rat Mcs6 Mammary carcinoma susceptibility QTL 6 7 2.29 34051 D7Mit28 35749 D7Rat45 34051 D7Mit28 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885;5133689 11139513;18057545;21625632 Mcs2 (sub_region) 7 33124095 71522360 1 - by flanking markers 7 29204226 68057251 1 - by flanking markers 61105 737908 WKY/NHsd WF/NHsd 7 33044449 71352127 1 - by flanking markers 7 26737401 63902784 1 - by flanking markers 70191 rat BpQTLcluster4 Blood pressure QTL cluster 4 3 3.0 34347 D3Mgh16 11260 D3Mit8 3632 Scn2a arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in systolic blood pressure (CMO:0000607) increased systemic arterial blood pressure hypertension 70067;68932 10779487 3 11361699 58322647 1 - by flanking markers 3 6373335 47588420 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 3 6000748 51687917 1 - by flanking markers 3 10778704 50302886 1 - by flanking markers 70192 rat BpQTLcluster5 Blood pressure QTL cluster 5 4 4.183 11383 D4Mit23 10144 D4Mgh16 3711 Slc4a2 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in pulse pressure (CMO:0001882);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);percent change in mean arterial blood pressure (CMO:0002035);percent change in systolic blood pressure (CMO:0000747);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 4 61427664 177782856 1 - by flanking markers 4 61646915 116611046 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 4 61708341 113100992 1 - by flanking markers 4 62933508 114921294 1 - by flanking markers 70193 rat Mcs7 Mammary carcinoma susceptibility QTL 7 10 2.38 35627 D10Rat12 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885;61516 11139513;18057545;11015598 10 75258929 112200500 5 - by peak with adj size 10 76698917 110718848 5 - by peak with adj size 61105 737908 WKY/NHsd WF/NHsd 10 75544754 112626471 5 - by peak with adj size 10 72224939 107211142 5 - by peak with adj size 70194 rat BpQTLcluster6 Blood pressure QTL cluster 6 5 4.125 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in systolic blood pressure (CMO:0000607);percent change in mean arterial blood pressure (CMO:0002035);percent change in systolic blood pressure (CMO:0000747) increased systemic arterial blood pressure hypertension 70067;68932 10779487 F2 SHRxBN 60985 61000 BN SHR 70195 rat Mcs8 Mammary carcinoma susceptibility QTL 8 14 4.28 36536 D14Rat1 40104 D14Rat99 60763 D14Wox3 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885 11139513;18057545 14 4830815 26295128 1 - by flanking markers 14 4895894 26416791 1 - by flanking markers 61105 737908 WKY/NHsd WF/NHsd 14 4833233 26466248 1 - by flanking markers 14 3813074 24531477 1 - by flanking markers 70196 rat BpQTLcluster7 Blood pressure QTL cluster 7 6 6.82 11241 D6Mit3 33624 D6Mit12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 6 2916542 85163175 1 - by flanking markers 6 3158498 75049527 1 - by flanking markers F2 GHxBN 60984 60985 GH BN 6 75623277 120623277 4 - by one flank marker only 6 72202632 117202632 4 - by one flank marker only 70197 rat BpQTLcluster8 Blood pressure QTL cluster 8 8 3.482 10177 D8Mit7 67379 Acaa1a arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 8 49155552 127243232 1 - by flanking markers 8 79313887 124313887 4 - by one flank marker only F2 SSxBN 60985 69369 BN SS 8 50529480 128036471 1 - by flanking markers 8 46531639 119088626 1 - by flanking markers 70198 rat BpQTLcluster9 Blood pressure QTL cluster 9 10 2.94 33891 D10Mit5 3710 Slc4a1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70067;68932 10779487 10 21392295 90101181 1 - by flanking markers 10 21607719 91471072 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 10 21523906 90312401 1 - by flanking markers 10 42323132 87323132 4 - by one flank marker only 70199 rat Coreg1 Compensatory renal growth QTL 1 6 11.8 12.0 36787 D6Rat37 33977 D6Mit4 33828 D6Mit9 kidney mass (VT:0002707) compensatory renal growth score (CMO:0001894) increased compensatory renal growth 70067;69708 10732705 2003;2023 Asip;Acp3 co-recessive Aia1 (maps to same region);Cia1 (maps to same region);Oia1 (maps to same region);Pia1 (maps to same region) 6 51322427 70194178 1 - by flanking markers 6 36481546 59946874 1 - by flanking markers SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 6 38196412 60606431 1 - by flanking markers 6 35691618 57730540 1 - by flanking markers 70200 rat Alc18 Alcohol consumption QTL 18 4 9.2 11.0 34308 D4Mgh9 33656 D4Mit9 35409 D4Rat34 drinking behavior trait (VT:0001422) ethanol intake volume to total fluid intake volume ratio (CMO:0001591) alcohol preference alcohol use disorder 70067;69704;631849;1578304;2317896;8662401 9880658;12665621;16470346;20200994;24611993 3197;3729;70547 Npy;Snca;Crhr2 additive 4 55067674 214306934 1 - by flanking markers 4 54828166 152570244 1 - by flanking markers intercross PxNP 634380 634381 iP/Iusm iNP/Iusm 4 55324953 148360954 1 - by flanking markers 4 56647873 149491524 1 - by flanking markers 70201 rat Gcr1 Gastric cancer resistance QTL 1 4 2.7 41232 D4Rat182 35088 D4Rat59 10158 D4Arb16 stomach morphology trait (VT:0000470) stomach tumor susceptibility score (CMO:0002043) decreased incidence of induced tumors Stomach Neoplasms 70067;69698 10706129 4 184956749 209380347 1 - by flanking markers 4 121990539 150048167 1 - by flanking markers (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 4 119705414 146087100 1 - by flanking markers 4 120260281 147278687 1 - by flanking markers 70202 rat Alc19 Alcohol consumption QTL 19 3 2.5 33782 D3Mit10 37010 D3Rat49 drinking behavior trait (VT:0001422) ethanol intake volume to total fluid intake volume ratio (CMO:0001591) alcohol preference alcohol use disorder 70067;69704 9880658 69364 Scn1a 3 1 33340453 4 - by one flank marker only 3 1 23762628 4 - by one flank marker only intercross PxNP 634380 634381 iP/Iusm iNP/Iusm 3 1 28136884 4 - by one flank marker only 3 1 27494778 4 - by one flank marker only 70203 rat Gcr2 Gastric cancer resistance QTL 2 3 2.6 34186 D3Mgh9 37010 D3Rat49 35054 D3Rat55 stomach morphology trait (VT:0000470) stomach tumor susceptibility score (CMO:0002043) decreased incidence of induced tumors Stomach Neoplasms 70067;69698 10706129 3 8648011 33340453 1 - by flanking markers 3 4010230 23762628 1 - by flanking markers (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 3 3285929 28136884 1 - by flanking markers 3 8658162 27494778 1 - by flanking markers 70204 rat Niddm20 Non-insulin dependent diabetes mellitus QTL 20 14 5.1 8.0E-6 34981 D14Rat23 45195 D14Wox7 37030 D14Rat3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance;impaired glucose tolerance type 2 diabetes mellitus 70067;69691;69696;625760;1643009;7207431;10755343 9824537;10594234;12420133;17710484;23118743;26296322 1306722;1308102 Coq2;Plac8 14 2222207 19130933 2 - by one flank and peak markers 14 1764386 18915962 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 2227825 19230541 2 - by one flank and peak markers 14 1217606 16960180 2 - by one flank and peak markers 70205 rat Gcr3 Gastric cancer resistance QTL 3 16 2.3 11446 D16Mgh4 42018 D16Arb3 37054 D16Rat17 stomach morphology trait (VT:0000470) stomach tumor depth of invasion (CMO:0001888);stomach tumor diameter (CMO:0001889) decreased incidence of induced tumors Stomach Neoplasms 70067;69698 10706129 16 19256518 70254563 1 - by flanking markers 16 18121291 70196694 1 - by flanking markers F2 (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 16 19398187 70590230 1 - by flanking markers 16 17696791 82635055 2 - by one flank and peak markers 70206 rat Alc20 Alcohol consumption QTL 20 8 2.0 33559 D8Mit5 36117 D8Rat46 drinking behavior trait (VT:0001422) ethanol intake volume to total fluid intake volume ratio (CMO:0001591) alcohol preference alcohol use disorder 70067;69704 9880658 2520;2846 Drd2;Htr1b 8 33603024 61319565 1 - by flanking markers 8 32203394 43314410 1 - by flanking markers intercross PxNP 634380 634381 iP/Iusm iNP/Iusm 8 33558660 44219353 1 - by flanking markers 8 30848154 40713225 1 - by flanking markers 70207 rat Niddm31 Non-insulin dependent diabetes mellitus QTL 31 7 3.9 35237 D7Rat35 34880 D7Rat31 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 70067;69696 10594234 7 24326613 32338830 1 - by flanking markers 7 20307479 28488710 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 7 24175337 32258115 1 - by flanking markers 7 18169505 26029351 1 - by flanking markers 70208 rat Niddm22 Non-insulin dependent diabetes mellitus QTL 22 11 3.61 10375 D11Mgh1 34112 D11Mgh4 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance;impaired glucose tolerance type 2 diabetes mellitus 70067;69691;69696;625760;7207431;10755342 9824537;10594234;12420133;23118743;25821834 1305614 Igf2bp2 11 65784538 89808355 1 - by flanking markers 11 61504483 84560092 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 11 62653365 86714483 1 - by flanking markers 11 59802794 82566553 1 - by flanking markers 70209 rat Niddm23 Non-insulin dependent diabetes mellitus QTL 23 1 2.82 11439 D1Mit30 43377 D1Wox9 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611 10594234;12420133;23118743;19697080 Gluco41 (maps to same region) 1 101048742 223187249 1 - by flanking markers 1 94473940 203416143 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 1 99983293 216325819 1 - by flanking markers 1 94494440 198324465 1 - by flanking markers 70210 rat Cm15 Cardiac mass QTL 15 17 6.5 22.0 45485 D17Wox9 35883 D17Rat44 36315 D17Rat41 heart right ventricle mass (VT:0007033) heart right ventricle wet weight (CMO:0000072) heart right ventricle hypertrophy;pulmonary hyperplasia;vascular smooth muscle hypertrophy Hyperplasia;Pulmonary Hypertension, Hypoxia-Induced ;Right Ventricular Hypertrophy;pulmonary hypertension 70067;69699;10401832 11157698;26258299 2343;620314;1309305 Chrm3;Ryr2;Slc39a12 dominant 17 63969458 75653670 1 - by flanking markers 17 65900398 81612488 1 - by flanking markers F2 F344xWKY 61097 61109 WKY/NCruk F344/NHsd 17 62195703 73981731 1 - by flanking markers 10401835 WKY.F344-(D17Got91-D17Rat51)/Tja 17 57246723 70156904 1 - by flanking markers 70211 rat Niddm24 Non-insulin dependent diabetes mellitus QTL 24 1 3.79 10674 D1Mgh12 35457 D1Rat90 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;11532750;2312611;1358859 10594234;12420133;23118743;27523322;19697080;15883013 620040;1559884 Prdx3;Plekhs1 Bw54 (maps to same region);Gluco51 (maps to same region) 1 270716905 289137268 1 - by flanking markers 1 247322146 267111153 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 1 236795785 281795785 4 - by one flank marker only 1302647 F344.OLETF-(D5Rat166-D5Rat90)/Tj 1 214647894 259647894 4 - by one flank marker only 70212 rat Niddm25 Non-insulin dependent diabetes mellitus QTL 25 5 3.54 34377 D5Mgh4 33680 D5Mit13 34047 D5Mit1 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611 10594234;12420133;23118743;19697080 Gluco42 (maps to same region) 5 1 140429983 2 - by one flank and peak markers 5 1 138272129 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 5 1 136640934 2 - by one flank and peak markers 5 1 131345958 2 - by one flank and peak markers 70213 rat Niddm27 Non-insulin dependent diabetes mellitus QTL 27 12 3.72 34417 D12Mgh2 33963 D12Mit4 34729 D12Mgh5 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611;7401255 10594234;12420133;23118743;19697080;23596094 Bw128 (maps to same region);Gluco44 (maps to same region) 12 24883568 45634190 1 - by flanking markers 12 18937438 39323046 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 12 22876297 43799153 1 - by flanking markers 12 19835789 38193007 1 - by flanking markers 70214 rat Niddm28 Non-insulin dependent diabetes mellitus QTL 28 14 4.06 60765 D14Wox5 35837 D14Rat27 2289 Cckar blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431 10594234;12420133;23118743 14 41435114 81531552 1 - by flanking markers 14 42599990 81222938 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 41637569 80841518 1 - by flanking markers 14 39998251 75582726 1 - by flanking markers 70215 rat Niddm29 Non-insulin dependent diabetes mellitus QTL 29 16 3.54 35527 D16Rat7 36988 D16Rat15 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431 10594234;12420133;23118743 16 20607927 79886465 1 - by flanking markers 16 19510772 80047126 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 16 20755556 80316424 1 - by flanking markers 16 19004435 75226532 1 - by flanking markers 70216 rat Cm14 Cardiac mass QTL 14 3 2.1 60801 D3Wox3 2534 Edn3 66594 D3Mco5 heart mass (VT:0007028) heart wet weight (CMO:0000069) enlarged heart;increased systemic arterial blood pressure hypertension 70067;69705;68910;7401270 9922389;10642295;23648703 3 36017179 178925563 1 - by flanking markers 3 27506718 166514051 1 - by flanking markers (SxR)xS 10040 10041 SR/Jr SS/Jr 3 30846101 172879276 1 - by flanking markers 3 31172320 163586636 1 - by flanking markers 70218 rat Cm28 Cardiac mass QTL 28 9 8.3 1.0E-4 31.9 37416 D9Rat70 61287 D9Uia6 35819 D9Rat26 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased systemic arterial blood pressure hypertension 70067;61516;2302803 11015598;18854752 additive Bp333 (maps to same region) 9 27914255 83452061 1 - by flanking markers 9 21667066 77171049 1 - by flanking markers F2;intercross SxSHR;SS/JrxSHR 10041 724574 SS/Jr SHR/NHsd 9 29075079 83686404 1 - by flanking markers 9 25268044 79271759 1 - by flanking markers 70220 rat Bp55 Blood pressure QTL 55 13 5.75 33733 D13Mit2 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 70067;61043 8952608 13 47487222 92487222 5 - by peak with adj size 13 39572400 84572400 5 - by peak with adj size F2 SHRxWKY 61000 61103 SHR WKY 13 42508345 87508345 5 - by peak with adj size 13 37374509 82374509 5 - by peak with adj size 70221 rat Bp56 Blood pressure QTL 56 X 4.9 6.1 34192 DXMgh9 33717 DXMit4 34924 DXRat15 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69713 9931114 X 61984911 71224072 1 - by flanking markers X 79626109 88514168 1 - by flanking markers F2 SBHxSBN 631572 631573 SBH/Ygl SBN/Ygl X 61398097 70352120 1 - by flanking markers X 57042141 65612192 1 - by flanking markers 70222 rat Eae2 Experimental allergic encephalomyelitis QTL 2 4 4.3 34200 D4Mgh1 34716 D4Mgh14 34200 D4Mgh1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69694 9973459 4 18184531 37534268 1 - by flanking markers 4 17617956 36592773 1 - by flanking markers F2 LEWxBN 60985 60999 BN LEW 4 18222187 37685319 1 - by flanking markers 4 21333343 39505420 1 - by flanking markers 70223 rat Bp57 Blood pressure QTL 57 10 5.0 33891 D10Mit5 35503 D10Rat20 35731 D10Rat33 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 10 21392295 83353613 1 - by flanking markers 10 21607719 84443989 1 - by flanking markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 10 21523906 83549467 1 - by flanking markers 10 1 80676123 2 - by one flank and peak markers 70224 rat Eae3 Experimental allergic encephalomyelitis QTL 3 10 4.1 33632 D10Mit10 34445 D10Mgh6 34318 D10Mgh10 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;Paresis;multiple sclerosis 70067;69694;2293859;2296064 9973459;16624898;18453595 Eae23 (sub_region);Eau7 (maps to same region) 10 27082535 63366218 1 - by flanking markers 10 27184741 67678060 1 - by flanking markers F2 LEWxBN 60985 60999 BN LEW 10 27237530 64648311 1 - by flanking markers 10 26521957 61345413 1 - by flanking markers 70225 rat Bp58 Blood pressure QTL 58 1 3.3 36596 D1Rat53 36640 D1Rat14 38028 D1Rat121 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 1 36395668 180434202 1 - by flanking markers 1 1 166496140 2 - by one flank and peak markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 1 34993530 173445086 1 - by flanking markers 1 32356093 162846471 1 - by flanking markers 70226 rat Eae4 Experimental allergic encephalomyelitis QTL 4 9 36984 D9Rat29 33842 D9Mit6 34264 D9Mgh5 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69712;7241236 10072499;20368159 3951 Vav1 Iresp3 (maps to same region) 9 28304251 46197383 2 - by one flank and peak markers 9 1526958 22066101 1 - by flanking markers F2 DAxBN 60985 60997 BN DA 9 1 29467098 2 - by one flank and peak markers 9 1 25661317 2 - by one flank and peak markers 70363 rat Bp71 Blood pressure QTL 71 10 0.04 34445 D10Mgh6 38516 D10Rat106 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 69734 11471055 3185 Nos2 10 63366082 84394530 1 - by flanking markers 10 67677924 85489479 1 - by flanking markers 631220 SS.LEW-(D10Mco1-D10Mco31)/Ayd 10 64648175 84601269 1 - by flanking markers 10 61345276 81714865 1 - by flanking markers 70364 rat Bp72 Blood pressure QTL 72 10 40794 D10Rat141 35256 D10Rat11 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 69734 11471055 2493 Ace 10 54184250 99184250 4 - by one flank marker only 10 55633982 100633982 4 - by one flank marker only 728137 SS.LEW-(D10Rat141-D10Mgh1)/Ayd 10 91548145 99492409 1 - by flanking markers 10 51121100 96121100 4 - by one flank marker only 71111 rat Iddm8 Insulin dependent diabetes mellitus QTL 8 6 1.9 0.002 10507 D6Mgh2 2880 Ighe 10507 D6Mgh2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) Experimental Diabetes Mellitus 61077;61480;619674;619685;2303106 9571179;9892222;9858659;11327715;19168599 Iddm29 (maps to same region) 6 141822172 147061209 1 - by flanking markers 6 110581307 147636619 5 - by peak with adj size F1;backcross BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 6 132652096 138068606 1 - by flanking markers 6 105156861 140994061 5 - by peak with adj size 71112 rat Bw115 Body weight QTL 115 1 6.0 1.0E-4 35457 D1Rat90 33903 D1Mit7 33694 D1Mit8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight;increased body weight;increased circulating glucose level type 2 diabetes mellitus 61072;619678;2312611;619669;1358859 9585427;10373320;19697080;11071303;15883013 additive Bw116 (maps to same region);Bw54 (maps to same region);Bw85 (maps to same region);Scl67 (interacts with);Stl31 (maps to same region) 1 262617374 289137107 1 - by flanking markers 1 240980321 267110921 1 - by flanking markers F2;intercross OLETFxBN 60985 61014 BN OLETF 1 281795624 282763074 4 - by one flank marker only 1 259647732 260522016 4 - by one flank marker only 71113 rat Cari2 Carrageenan-induced inflammation QTL 2 2 2.7 0.009 33983 D2Mit23 34461 D2Mgh12 10582 D2Mit12 hypodermis integrity trait (VT:0010550) inflammatory exudate volume (CMO:0001429) abnormal inflammatory response Inflammation;hyperglycemia 70860;69693;61072;69694 11306811;10087293;9585427;9973459 recessive 2 166931667 235592880 1 - by flanking markers 2 146659370 210636169 1 - by flanking markers F2;intercross F344xLEW 60999 70509 LEW F344/NRrrc 2 147522550 217498710 1 - by flanking markers 2 141596551 202447032 1 - by flanking markers 71114 rat Niddm14 Non-insulin dependent diabetes mellitus QTL 14 7 4.5 10431 D7Wox18 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased body weight;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 61072;2296064 9585427;18453595 Eau6 (maps to same region) 7 93629275 138629275 5 - by peak with adj size 7 90478161 135478161 5 - by peak with adj size F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 7 93726906 138726906 5 - by peak with adj size 7 84257275 129257275 5 - by peak with adj size 71115 rat Niddm15 Non-insulin dependent diabetes mellitus QTL 15 14 4.8 34981 D14Rat23 33953 D14Mit1 33579 D14Mit5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance;increased body weight;increased circulating glucose level type 2 diabetes mellitus 61072 9585427 14 2222207 12623486 1 - by flanking markers 14 1764386 12386683 1 - by flanking markers F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 14 2227825 12680613 1 - by flanking markers 14 1217606 11030812 1 - by flanking markers 71116 rat Niddm16 Non-insulin dependent diabetes mellitus QTL 16 X 7.81 34405 DXMgh2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 2 diabetes mellitus 70858;619678 7607056;10373320 3225 Odb1 X 18462583 63462583 5 - by peak with adj size X 36612231 81612231 5 - by peak with adj size F2;backcross OLETFxBN 60985 61014 BN OLETF X 18153352 63153352 5 - by peak with adj size X 15297802 60297802 5 - by peak with adj size 71117 rat Niddm17 Non-insulin dependent diabetes mellitus QTL 17 14 2.35 11030 D14Mit4 10113 D14Mit2 11030 D14Mit4 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance 70861 8702404 3226 Odb2 14 21276795 66276795 5 - by peak with adj size 14 22520291 67520291 5 - by peak with adj size F2 OLETFxBN 61014 634367 OLETF BN/CrlCrlj 14 19161893 43957503 1 - by flanking markers 14 17593761 42336881 1 - by flanking markers 71118 rat Thym1 Thymus enlargement QTL 1 1 10.17 0.001 33571 D1Mit6 10952 D1Wox21 11201 D1Mgh11 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) thymus hyperplasia Thymus Hyperplasia 70859;634747;631171 10792781;8672128;9716658 Thym3 (interacts with);Thym4 (sub_region) 1 160649707 205649707 4 - by one flank marker only 1 141471946 186471946 4 - by one flank marker only F1;backcross WKY/NCrjxBUF/Mna 61118 61119 BUF/Mna WKY/NCrlCrlj 1 153655976 198655976 4 - by one flank marker only 1 136829932 181829932 4 - by one flank marker only 71119 rat Thym2 Thymus enlargement QTL 2 13 3.8 10205 D13Mgh17 3804 Syt2 41967 D13Arb10 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) thymus hyperplasia Thymus Hyperplasia 70859;634747;631171 10792781;8672128;9716658 13 56630530 95196860 1 - by flanking markers 13 47699094 88282502 1 - by flanking markers F1;backcross WKY/NCrjxBUF/Mna 61118 61119 BUF/Mna WKY/NCrlCrlj 13 51577824 90675199 1 - by flanking markers 13 46197976 84753113 1 - by flanking markers 71120 rat Niddm21 Non-insulin dependent diabetes mellitus QTL 21 8 3.73 10435 D8Mgh7 36039 D8Rat58 34723 D8Mgh9 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 61021;625760;2300331;7207431;2298688 10051320;12420133;18421176;23118743;18612083 Gluco36 (maps to same region) 8 1 3460265 4 - by one flank marker only 8 3039822 61462321 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 8 1 3442354 4 - by one flank marker only 8 1 3402289 4 - by one flank marker only 619613 rat Bp77 Blood pressure QTL 77 1 0.01 10165 D1Wox34 36566 D1Rat55 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70855;1625015 11509479;17332427 62086 Acsm3 1 182435050 184481458 1 - by flanking markers 1 168382195 170489972 1 - by flanking markers F2;intercross SHRxWKY;WKY.SHR-SaxSHR.WKY-Sa 631589 SHR.WKY-(D1Wox34-D1Rat164)/Njs 1 175447029 220447029 4 - by one flank marker only 1 164747424 209747424 4 - by one flank marker only 619614 rat Bp78 Blood pressure QTL 78 1 0.001 36454 D1Rat56 36239 D1Rat111 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70855;1625015 11509479;17332427 62086 Acsm3 1 191393321 222009153 1 - by flanking markers 1 172926151 202350882 1 - by flanking markers F2;intercross SHRxWKY;WKY.SHR-SaxSHR.WKY-Sa 631591 631592 WKY.SHR-(D1Rat56-D1M7Mit206)/Njs WKY.SHR-(D1Rat236-D1M7Mit206)/Njs 1 184419946 215097919 1 - by flanking markers 1 169112897 197261052 1 - by flanking markers 619615 rat Bp80 Blood pressure QTL 80 13 0.0354 34029 D3Mit1 2168 Atp1a2 11231 D13Wox5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70857 9299556 3554 Ren dominant 13 15923248 95198290 2 - by one flank and peak markers 13 4256134 88283918 2 - by one flank and peak markers F2;backcross SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 13 45676629 90676629 4 - by one flank marker only 13 39754544 84754544 4 - by one flank marker only 619616 rat Bp79 Blood pressure QTL 79 4 0.0292 2901 Il6 11015 D4Mit24 60732 D4Mit6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70857;61035 9299556;9780220 3197 Npy dominant 4 3095536 144249450 1 - by flanking markers 4 456799 78039637 1 - by flanking markers F2;backcross SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 4 3043231 79575658 1 - by flanking markers 4 5214602 78882945 1 - by flanking markers 619617 rat Bp283 Blood pressure QTL 283 17 2.61 0.002 35505 D17Rat54 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70856 11053483 F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 619618 rat Rf3 Renal disease susceptibility QTL 3 3 6.5 0.001 33808 D3Mit4 urine albumin amount (VT:0002871) urine albumin excretion rate to body weight ratio (CMO:0001270) glomerulosclerosis;increased urine protein level end stage renal disease 70856 11053483 3 120821325 165821325 5 - by peak with adj size 3 108688653 153688653 5 - by peak with adj size F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 3 114376250 159376250 5 - by peak with adj size 3 107693393 152693393 5 - by peak with adj size 619619 rat Rf4 Renal disease susceptibility QTL 4 14 4.1 0.002 34479 D14Mgh7 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) glomerulosclerosis end stage renal disease 70856;1582571 11053483;16837819 14 1 34346301 5 - by peak with adj size 14 1 34067237 5 - by peak with adj size F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 14 1 34403399 5 - by peak with adj size 14 1 32754612 5 - by peak with adj size 619620 rat Rf5 Renal disease susceptibility QTL 5 17 2.99 0.001 36331 D17Mit12 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) glomerulosclerosis;increased urine protein level end stage renal disease 70856;1582571 11053483;16837819 F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 631198 rat Cm22 Cardiac mass QTL 22 2 4.3 8.0E-4 22.4 33620 D2Mit6 34204 D2Mgh7 34114 D2Mgh15 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy 61484 9495256 recessive Cm23 (interacts with);Cm25 (interacts with) 2 98037122 177517146 1 - by flanking markers 2 77630629 156142910 1 - by flanking markers intercross SHRxDRY 60995 728194 DRY SHR/N 2 78321410 158159410 1 - by flanking markers 2 76539322 150540526 1 - by flanking markers 631199 rat Cm23 Cardiac mass QTL 23 1 4.6 4.0E-4 24.5 34399 D1Mgh9 34011 D1Mit2 33959 D1Mit3 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy Left Ventricular Hypertrophy 61484 9495256 recessive Cm22 (interacts with);Cm25 (interacts with) 1 130149502 195235510 2 - by one flank and peak markers 1 134980682 176854992 1 - by flanking markers intercross SHRxDRY 60995 728194 DRY SHR/N 1 124603592 188289386 2 - by one flank and peak markers 1 115585465 172949803 2 - by one flank and peak markers 631200 rat Cm25 Cardiac mass QTL 25 3 4.8 1.0E-4 16.5 35380 D3Rat27 34979 D3Rat38 34918 D3Rat29 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy Left Ventricular Hypertrophy 69706;61484 10205229;9495256 3439 Ptgs1 dominant Cm22 (interacts with);Cm23 (interacts with) 3 69593925 99297509 1 - by flanking markers 3 58882977 87981062 1 - by flanking markers intercross WKYxF344 61097 61109 WKY/NCruk F344/NHsd 3 63049050 92654302 1 - by flanking markers 3 61134348 89115068 1 - by flanking markers 631201 rat Panci1 Pancreas inflammation QTL 1 7 0.0 0.001 12.0 35304 D7Rat4 38306 D7Rat97 pancreas integrity trait (VT:0010560) percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214) increased body weight;pancreas inflammation pancreatitis 619682 11414764 additive 7 126177060 136963167 1 - by flanking markers 7 123574930 134614033 1 - by flanking markers intercross BNxWBN/Kob;BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc 7 126463827 137325116 1 - by flanking markers 7 116677189 127103496 1 - by flanking markers 631202 rat Gluco13 Glucose level QTL 13 1 1.0E-4 0.1 36023 D1Rat38 619844 Cnga4 33959 D1Mit3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance;increased body weight type 2 diabetes mellitus 631173 12705906 1 140507063 177253787 1 - by flanking markers 1 133566530 163141556 1 - by flanking markers backcross SDTxBN 631219 1549801 SDT/Jcl BN/Seac 1 139523928 170246858 1 - by flanking markers 1 131763437 159756369 1 - by flanking markers 631203 rat Gluco14 Glucose level QTL 14 2 1.0E-4 0.1 38466 D2Rat118 38942 D2Rat156 2591 Fabp2 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 631173 12705906 2591 Fabp2 2 239931503 254122318 1 - by flanking markers 2 214988814 227924156 1 - by flanking markers backcross SDTxBN 631219 1549801 SDT/Jcl BN/Seac 2 221880206 235570970 1 - by flanking markers 2 206665645 219003804 1 - by flanking markers 631204 rat Gluco15 Glucose level QTL 15 X 0.001 0.08 11236 DXWox11 39154 DXRat83 11494 DXWox20 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 631173 12705906 X 2631211 24746304 1 - by flanking markers X 13041853 43167410 1 - by flanking markers backcross SDTxBN 631219 1549801 SDT/Jcl BN/Seac X 1838166 24331837 1 - by flanking markers X 1623715 22646544 1 - by flanking markers 631205 rat Bp196 Blood pressure QTL 196 1 4.0 1.0E-4 34.4 34244 D1Mgh10 34134 D1Mgh1 33959 D1Mit3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 61484 9495256 additive 1 127336420 223910550 1 - by flanking markers 1 119780561 204280278 1 - by flanking markers intercross SHRxDRY 60995 728194 DRY SHR/N 1 126240667 217054291 1 - by flanking markers 1 118944897 199050459 1 - by flanking markers 631206 rat Niddm40 Non-insulin dependent diabetes mellitus QTL 40 1 33806 D1Mit24 60788 D1Wox7 33770 D1Mit12 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 619671 10902185 1 145651184 181328888 1 - by flanking markers 1 139026999 167337781 1 - by flanking markers intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 1 144723107 174343537 1 - by flanking markers 1 136745990 163747690 1 - by flanking markers 631207 rat Niddm41 Non-insulin dependent diabetes mellitus QTL 41 17 34276 D17Mgh2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 619671 10902185 17 1 40301379 5 - by peak with adj size 17 1 43786390 5 - by peak with adj size intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 17 1 38243814 5 - by peak with adj size 17 1 37830672 5 - by peak with adj size 631208 rat Bw1 Body weight QTL1 2 5.09 13.8 60793 D2Wox3 34190 D2Mgh19 mesenteric fat pad mass (VT:0010427) mesenteric fat pad weight to body weight ratio (CMO:0000654) abnormal abdominal fat pad morphology obesity 619690 11087657 semidominant 2 62195476 105314072 1 - by flanking markers 2 42882523 84991985 1 - by flanking markers F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 2 43149788 85642672 1 - by flanking markers 2 43171017 83575226 1 - by flanking markers 631209 rat Bw2 Body weight QTL2 4 4.2 11.3 36476 D4Rat3 35625 D4Rat14 34200 D4Mgh1 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690 11087657 recessive 4 6487066 44024417 1 - by flanking markers 4 5351609 41729771 1 - by flanking markers F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 4 6467693 43414792 1 - by flanking markers 4 9940885 44463908 1 - by flanking markers 631210 rat Bw3 Body weight QTL3 8 5.9 34152 D8Mgh17 35717 D8Rat9 34310 D8Mgh4 mesenteric fat pad mass (VT:0010427) mesenteric fat pad weight to body weight ratio (CMO:0000654) abnormal abdominal fat pad morphology obesity 619690 11087657 additive 8 76889142 120414001 1 - by flanking markers 8 73102005 117434131 1 - by flanking markers OLETFxF344 61014 70509 OLETF F344/NRrrc 8 74917593 121080545 1 - by flanking markers 8 69349194 112783834 1 - by flanking markers 631211 rat Bw4 Body weight QTL4 9 5.31 16.5 35695 D9Rat44 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690 11087657 recessive 9 2813697 47813697 4 - by one flank marker only 9 2948882 47948882 4 - by one flank marker only OLETFxF344 61014 70509 OLETF F344/NRrrc 9 2880977 47880977 4 - by one flank marker only 9 5109826 50109826 4 - by one flank marker only 631212 rat Bw5 Body weight QTL5 14 5.43 12.4 35342 D14Rat8 33953 D14Mit1 60763 D14Wox3 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690;2298688 11087657;18612083 recessive Gluco38 (maps to same region) 14 12623486 32389647 1 - by flanking markers 14 12386683 32584630 1 - by flanking markers intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 14 12680613 32593926 1 - by flanking markers 14 11030812 30320092 1 - by flanking markers 631213 rat Bw60 Body weight QTL60 14 4.51 13.8 36512 D14Rat18 35897 D14Rat22 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690 11087657 recessive 14 85985284 106705037 1 - by flanking markers 14 85715836 102509397 1 - by flanking markers intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 14 85307663 106641756 1 - by flanking markers 14 79950921 95876975 1 - by flanking markers 631214 rat Bw61 Body weight QTL61 1 3.4 1.0E-4 5.0 33903 D1Mit7 37754 D1Rat123 intramuscular adipose amount (VT:0010044) intramuscular fat area (CMO:0001162) abnormal adipose tissue distribution obesity 619672 11853145 recessive 1 245519018 262617194 1 - by flanking markers 1 223729371 240980142 1 - by flanking markers intercross F344xOLETF 61014 70509 OLETF F344/NRrrc 1 193220385 238220385 4 - by one flank marker only 1 173108781 218108781 4 - by one flank marker only 631215 rat Stl8 Serum triglyceride level QTL 8 1 9.27 1.0E-4 13.6 34009 D1Mit34 35457 D1Rat90 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 70852 10644432 1 252776360 290094216 2 - by one flank and peak markers 1 230963695 267910886 2 - by one flank and peak markers backcross BNxOLETF 60985 61014 BN OLETF 1 245529606 282763074 2 - by one flank and peak markers 1 225126575 260522016 2 - by one flank and peak markers 631216 rat Stl9 Serum triglyceride level QTL 9 8 4.71 1.0E-4 7.1 35987 D8Rat30 33858 D8Mit4 33973 D8Mit2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 70852 10644432 8 44187677 80296781 1 - by flanking markers 8 44484347 74178405 1 - by flanking markers backcross BNxOLETF 60985 61014 BN OLETF 8 45712475 75971259 1 - by flanking markers 8 41867010 70386132 1 - by flanking markers 631217 rat Activ1 Activity QTL 1 8 15.9 35.0 33919 D8Mit15 10169 D8Wox11 34068 D8Mgh11 voluntary movement trait (VT:0003491) number of photobeam interruptions in an experimental apparatus (CMO:0001517) hyperactivity;increased exploration in new environment Hyperkinesis 631170;631228;1358767 8944030;12660808;15685431 Activ2 (maps to same region);Stresp11 (maps to same region) 8 109621234 116312980 2 - by one flank and peak markers 8 106733287 113364148 1 - by flanking markers intercross WKYxWKHA 61103 68186 WKY WKHA/N 8 110212979 116947981 2 - by one flank and peak markers 8 102370617 108923645 2 - by one flank and peak markers 631260 rat Tcas2 Tongue tumor susceptibility QTL 2 1 4.93 34326 D1Mgh21 34244 D1Mgh10 33753 D1Mit5 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 631169;634723 12448007;11429048 1 216945382 223910677 1 - by flanking markers 1 197423292 204280406 1 - by flanking markers intercross DAxWF 60997 61007 DA WF 1 210019247 217054418 1 - by flanking markers 1 192485903 199050587 1 - by flanking markers 631261 rat Tcas3 Tongue tumor susceptibility QTL 3 4 6.88 33905 D4Mit11 3186 Nos3 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 631169;634723 12448007;11429048 4 7353767 157291086 1 - by flanking markers 4 6179441 91330582 1 - by flanking markers intercross WFxDA 60997 61007 DA WF 4 7342404 92484039 1 - by flanking markers 4 10814170 91360527 1 - by flanking markers 631262 rat Tcas4 Tongue tumor susceptibility QTL 4 14 7.29 60762 D14Wox10 11030 D14Mit4 60764 D14Wox4 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 631169;634723 12448007;11429048 14 19098311 43777078 1 - by flanking markers 14 19141961 45020354 1 - by flanking markers intercross DAxWF 60997 61007 DA WF 14 19191541 43957628 1 - by flanking markers 14 17622561 42337007 1 - by flanking markers 631263 rat Cm24 Cardiac mass QTL 24 5 3.5 18.6 40376 D5Rat173 11001 D5Wox10 39168 D5Rat99 heart mass (VT:0007028) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy 619659;731210 11157676;14678232 3193 Nppa codominant Bp155 (maps to same region);Lanf1 (maps to same region) 5 153656532 168465304 2 - by one flank and peak markers 5 150310201 165073513 2 - by one flank and peak markers intercross WKY/CfdxWKHA/Cfd 1579699 WKY.WKHA-(D5Rat45-D5Rat245)/Cfd 5 149832180 164807402 2 - by one flank and peak markers 5 143799107 158428037 2 - by one flank and peak markers 631264 rat Scl22 Serum cholesterol level QTL 22 18 6.2 3916 Ttr 2741 Nr3c1 3916 Ttr blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 61055 9199194 18 15307563 32348480 1 - by flanking markers 18 12406571 32459145 1 - by flanking markers intercross BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 18 15532963 32704022 1 - by flanking markers 18 11941791 31393320 1 - by flanking markers 631265 rat Iresp1 Immunoglobin response QTL1 20 8.3 17.0 34260 D20Mgh5 45676 D20Got13 37872 D20Rat31 blood anti-double stranded DNA antibody amount (VT:0004762) serum anti-DNA antibody level (CMO:0001533) increased susceptibility to type II hypersensitivity reaction allergic disease 619646 10898507 additive 20 11836888 16594863 1 - by flanking markers 20 9301974 13963223 1 - by flanking markers intercross LEW/RjxBN/Rj 631593 631594 LEW/Rj BN/Rj 20 9655642 14411641 1 - by flanking markers 20 9039719 13461775 1 - by flanking markers 631266 rat Bp132 Blood pressure QTL 132 2 5.0E-4 2633 Fst 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension 68910;619621;2301356;7401270 10642295;10406815;18819818;23648703 2071;2167;2263;1306589 Agtr1b;Atp1a1;Camk2d;Gca Bp13 (maps to same region);Bp14 (maps to same region);Bp163 (interacts with) 2 65576721 235592880 1 - by flanking markers 2 46542246 210636169 1 - by flanking markers congenic SS/JrxSR/Jr 631278 SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc 2 46537589 217498710 1 - by flanking markers 2 46123260 202447032 1 - by flanking markers 631267 rat Cia20 Collagen induced arthritis QTL 20 10 3.2 61274 D10Arb20 61275 D10Arb22 44839 D10Wox7 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 recessive Cia21 (interacts with,maps to same region);Cia22 (interacts with);Cia23 (interacts with);Cia5 (maps to same region,interacts with) 10 24340447 107484761 1 - by flanking markers 10 24006429 110718848 2 - by one flank and peak markers intercross 61109 631182 F344/NHsd DA/BklArbN 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers 631268 rat Cia21 Collagen induced arthritis QTL 21 10 3.1 33585 D10Mit6 61275 D10Arb22 36749 D10Rat19 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 Cia20 (interacts with,maps to same region);Cia22 (interacts with);Cia23 (interacts with);Cia5 (maps to same region,interacts with) 10 14644150 107484761 1 - by flanking markers 10 14721135 110718848 2 - by one flank and peak markers 61109 631182 F344/NHsd DA/BklArbN 10 14827894 107857673 1 - by flanking markers 10 14487011 104060283 1 - by flanking markers 631269 rat Cia22 Collagen induced arthritis QTL 22 10 8.9 34053 D10Mit3 61275 D10Arb22 34485 D10Mgh4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 Cia20 (interacts with);Cia21 (interacts with);Cia23 (maps to same region);Cia5 (maps to same region,interacts with) 10 41091453 107484761 1 - by flanking markers 10 41339689 110718848 2 - by one flank and peak markers 10008 631182 BN/SsNHsd DA/BklArbN 10 41260363 107857673 1 - by flanking markers 10 40035094 104060283 1 - by flanking markers 631270 rat Cia23 Collagen induced arthritis QTL 23 10 3.9 34053 D10Mit3 61275 D10Arb22 34485 D10Mgh4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 Cia20 (interacts with);Cia21 (interacts with);Cia22 (maps to same region);Cia5 (maps to same region,interacts with) 10 41091453 107484761 1 - by flanking markers 10 41339689 110718848 2 - by one flank and peak markers 10008 631182 BN/SsNHsd DA/BklArbN 10 41260363 107857673 1 - by flanking markers 10 40035094 104060283 1 - by flanking markers 631271 rat Lecl1 Lens clarity QTL 1 8 0.001 37712 D8Rat68 42225 D8Arb13 lens clarity trait (VT:0001304) age of onset/diagnosis of cataract (CMO:0001584) cornea opacity Corneal Opacity;cataract 68701 11252169 recessive 8 21522570 90659889 1 - by flanking markers 8 19460544 88679394 1 - by flanking markers intercross IExWKY/Izm 631285 631286 IER/Ihr WKY/Izm 8 21464919 91140553 1 - by flanking markers 8 18984168 84531599 1 - by flanking markers 631272 rat Lanf1 Left ventricular atrial natriuretic factor QTL 1 5 12.0 44.3 39168 D5Rat99 42770 D5Rat245 41070 D5Rat180 heart left ventricle natriuretic peptide A amount (VT:0010596) heart left ventricle natriuretic peptide A level (CMO:0002165) increased circulating atrial natriuretic factor Left Ventricular Hypertrophy 619659;731210 11157676;14678232 3193 Nppa codominant Bp155 (maps to same region);Cm24 (maps to same region) 5 161060798 177180328 2 - by one flank and peak markers 5 157691737 173096209 2 - by one flank and peak markers intercross WKY/CfdxWKHA/Cfd 631275 631276 WKY/Cfd WKHA/Cfd 5 157319671 173707219 2 - by one flank and peak markers 5 151113452 166875058 2 - by one flank and peak markers 631273 rat Lecl2 Lens clarity QTL 2 15 0.001 37308 D15Rat52 34471 D15Mgh3 lens clarity trait (VT:0001304) age of onset/diagnosis of cataract (CMO:0001584) cornea opacity Corneal Opacity;cataract 68701 11252169 recessive 15 21251142 66251142 4 - by one flank marker only 15 16458810 61458810 4 - by one flank marker only intercross IExWKY/Izm 631285 631286 IER/Ihr WKY/Izm 15 39480797 62596410 1 - by flanking markers 15 10596089 55596089 4 - by one flank marker only 631274 rat Sprol1 Serum protein level QTL 1 18 5.3 33814 D18Mit9 2741 Nr3c1 2715 Gnal blood total protein amount (VT:0005567) serum total protein level (CMO:0000661) increased circulating total protein level disease of metabolism 61055;61056 9199194;9241273 18 32348480 79748238 1 - by flanking markers 18 32459145 80370367 1 - by flanking markers intercross BB/OK;SHR/Mol 61107 61110 BB/OK SHR/Mol 18 32704022 80696226 1 - by flanking markers 18 31393320 77209694 1 - by flanking markers 631494 rat Bp95 Blood pressure QTL 95 1 40.0 1.0E-4 62499 D1Uia8 35517 D1Rat18 37598 D1Rat176 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 68885 11160999 3720 Slc9a3 Bp27 (interacts with);Bp30 (interacts with) 1 23257188 50297622 2 - by one flank and peak markers intercross SSxLEW 631571 SS.LEW-(D1Uia8-D1Mco38)/Jr 1 21300822 49454378 2 - by one flank and peak markers 1 16206210 49268520 2 - by one flank and peak markers 631495 rat Bp96 Blood pressure QTL 96 1 4.52 23.9 34662 D1Mgh2 33686 D1Mit11 34037 D1Mit1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619642;631172 9449402;12441404 additive 1 24875821 109100951 1 - by flanking markers 1 22842898 102532417 1 - by flanking markers intercross SBH/yxSBN/y 631572 631573 SBH/Ygl SBN/Ygl 1 23406428 108057505 1 - by flanking markers 1 22340647 102268831 1 - by flanking markers 631496 rat Bp97 Blood pressure QTL 97 1 3.08 30.0 34381 D1Mgh7 33646 D1Mit4 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619642;631172 9449402;12441404 additive 1 114600888 159600888 4 - by one flank marker only 1 106445165 163516043 2 - by one flank and peak markers intercross SBH/yxSBN/y 631572 631573 SBH/Ygl SBN/Ygl 1 113593576 158593576 4 - by one flank marker only 1 106047847 151047847 4 - by one flank marker only 631497 rat Bp98 Blood pressure QTL 98 17 3.66 12.6 34369 D17Mgh4 10348 D17Mit4 34120 D17Mgh5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619642 9449402 additive 17 36585991 65757501 2 - by one flank and peak markers 17 46994933 71214857 2 - by one flank and peak markers intercross SBH/yxSBN/y 631572 631573 SBH/Ygl SBN/Ygl 17 42956021 63994435 2 - by one flank and peak markers 17 41354651 60463643 2 - by one flank and peak markers 631498 rat Bp100 Blood pressure QTL 100 5 4.9 0.001 13.5 3193 Nppa 3194 Nppb 3194 Nppb arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619655 9171954 5 168455640 168466309 1 - by flanking markers 5 165063650 165074518 1 - by flanking markers backcross SHRxWKY 61000 61103 SHR WKY 5 164797538 164808407 1 - by flanking markers 5 158418175 158429042 1 - by flanking markers 631499 rat Stl1 Serum triglyceride level QTL 1 17 3.6 2091 Aldoc 45450 D17Wox3 34276 D17Mgh2 blood triglyceride amount (VT:0002644) blood triglyceride level (CMO:0000118) increased circulating triglyceride level Hypertriglyceridemia;arteriosclerosis 619656 11414700 17 5621596 29981162 2 - by one flank and peak markers 17 8933253 33639527 2 - by one flank and peak markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 17 3414039 28073589 2 - by one flank and peak markers 17 3271398 27389946 2 - by one flank and peak markers 631500 rat Bp99 Blood pressure QTL 99 2 2.5 6.9 2391 Cpb1 3407 Prlr 2071 Agtr1b arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619650 7852741 2 84554681 124787804 1 - by flanking markers 2 59701221 105413336 1 - by flanking markers intercross SS/JrxAS 10041 67958 SS/Jr AS 2 60325686 105059293 1 - by flanking markers 2 59324719 102755241 1 - by flanking markers 631501 rat Bp101 Blood pressure QTL 101 2 2.4 34461 D2Mgh12 33747 D2Mit10 33747 D2Mit10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 dominant 2 177277204 235592715 1 - by flanking markers 2 155920808 210636008 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 2 157914409 217498545 1 - by flanking markers 2 150341684 202446871 1 - by flanking markers 631502 rat Cm26 Cardiac mass QTL 26 17 3.71 34989 D17Rat39 35827 D17Rat52 35827 D17Rat52 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy Left Ventricular Hypertrophy 619658 11045938 dominant 17 71046400 86907303 1 - by flanking markers 17 76829512 92594341 1 - by flanking markers intercross LEW/CrjxSHR/Izm 631576 631577 LEW/CrlCrlj SHR/Izm 17 69333272 85183543 1 - by flanking markers 17 65703580 81153923 1 - by flanking markers 631503 rat Bp102 Blood pressure QTL 102 7 1.9 2868 Igf1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 recessive 7 6067956 51067956 5 - by peak with adj size 7 2068705 47068705 5 - by peak with adj size backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 7 5951969 50951969 5 - by peak with adj size 7 1 44822433 5 - by peak with adj size 631504 rat Cm27 Cardiac mass QTL 27 7 3.45 35122 D7Rat9 37258 D7Rat107 37642 D7Rat112 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy;increased systemic arterial blood pressure Left Ventricular Hypertrophy;hypertension 619658 11045938 codominant 7 50717775 127783388 1 - by flanking markers 7 47865637 125399168 1 - by flanking markers intercross LEW/CrjxSHR/Izm 631576 631577 LEW/CrlCrlj SHR/Izm 7 50704769 128085642 1 - by flanking markers 7 44421311 118198041 1 - by flanking markers 631505 rat Bp103 Blood pressure QTL 103 5 3.2 3704 Slc2a1 34248 D5Mgh9 34443 D5Mgh8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 recessive 5 141964114 175858487 1 - by flanking markers 5 139690801 171801867 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 5 138154677 172402610 1 - by flanking markers 5 132717196 165560427 1 - by flanking markers 631506 rat Bp104 Blood pressure QTL 104 11 2.8 10376 D11Wox6 34112 D11Mgh4 3761 Sst arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 recessive 11 65784538 89808347 1 - by flanking markers 11 61504483 84560085 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 11 62653365 86714475 1 - by flanking markers 11 59802794 82566545 1 - by flanking markers 631507 rat Bp105 Blood pressure QTL 105 2 0.001 38626 D2Rat171 67315 D2Arb24 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) cardiac hypertrophy;increased systemic arterial blood pressure Cardiomegaly;hypertension 619651 11403354 2 135770850 248088631 1 - by flanking markers 2 116874922 221284686 1 - by flanking markers intercross 631578 SHR.BN-(D2Rat171-D2Arb24)/Ipcv 2 116075644 228737869 1 - by flanking markers 2 112456140 212696837 1 - by flanking markers 631508 rat Sald1 Serum aldosterone level QTL 1 1 3.7 36640 D1Rat14 blood aldosterone amount (VT:0005346) serum aldosterone level (CMO:0000487) increased circulating aldosterone level arteriosclerosis 629577 12482837 1 13895577 58895577 5 - by peak with adj size 17 1 24981037 5 - by peak with adj size BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 1 12493439 57493439 5 - by peak with adj size 1 9856001 54856001 5 - by peak with adj size 631509 rat Sald2 Serum aldosterone level QTL 2 18 2.9 37568 D18Rat55 35977 D18Rat8 blood aldosterone amount (VT:0005346) serum aldosterone level (CMO:0000487) increased circulating aldosterone level arteriosclerosis 629577 12482837 18 53346348 70825941 1 - by flanking markers 18 54856551 72450442 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 18 54108375 71692768 1 - by flanking markers 18 52539763 69140759 1 - by flanking markers 631510 rat Spl2 Serum phospholipid level QTL 2 11 4.1 35096 D11Rat10 blood phospholipid amount (VT:0006084) serum phospholipid level (CMO:0001171) hyperlipidemia arteriosclerosis;familial hyperlipidemia 629577 12482837 BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 631511 rat Pia7 Pristane induced arthritis QTL 7 4 4.3 10158 D4Arb16 34338 D4Mgh11 36143 D4Rat60 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 629570;629560;2307198;2300074;1582387;2324629;2302026;61067;61087 11090241;12571866;18540828;18606636;16804090;20200546;14674011;11001927;9600974 recessive Cia13 (maps to same region);Oia2 (maps to same region);Pia32 (interacts with) 4 196023944 230565226 1 - by flanking markers 4 133939407 171204531 1 - by flanking markers intercross 737950 2324631 DA/Ztm DA.E3-(D4Wox49-D4Got136)/Rhd 4 131532269 168047091 1 - by flanking markers 4 131730738 167139601 1 - by flanking markers 631512 rat Scl6 Serum cholesterol level QTL 6 1 9.6 35106 D1Rat335 36765 D1Rat27 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 1 68007159 95301868 1 - by flanking markers 1 71659707 90282193 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 1 67227683 94201552 1 - by flanking markers 1 72197680 90508767 1 - by flanking markers 631513 rat Scl7 Serum cholesterol level QTL 7 7 4.1 38198 D7Rat69 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 7 45491510 90491510 5 - by peak with adj size 7 42112081 87112081 5 - by peak with adj size BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 7 45301573 90301573 5 - by peak with adj size 7 37960569 82960569 5 - by peak with adj size 631514 rat Scl8 Serum cholesterol level QTL8 2 4.4 34858 D2Rat69 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 2 250313889 285068071 5 - by peak with adj size 2 224795742 258207540 5 - by peak with adj size BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 2 231621666 266435125 5 - by peak with adj size 631515 rat Bw10 Body weight QTL 10 10 3.5 10662 D10Wox23 61296 Aoc1 34330 D10Mgh2 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619656 11414700 10 84740741 110718848 2 - by one flank and peak markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 631516 rat Gluco31 Glucose level QTL 31 15 7.0 34160 D15Mgh5 34471 D15Mgh3 2536 Ednrb blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia 619656 11414700 15 66251142 106602088 1 - by flanking markers 15 61458810 102741229 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 15 62596410 103164962 1 - by flanking markers 15 55596089 95018120 1 - by flanking markers 631517 rat Scl9 Serum cholesterol level QTL 9 16 3.3 35005 D16Rat6 38370 D16Rat44 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 16 17191679 22636409 1 - by flanking markers 16 16194598 22671959 1 - by flanking markers BC/CpbuxLew/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 16 17309396 22744540 1 - by flanking markers 16 15726433 21034895 1 - by flanking markers 631518 rat Bw11 Body weight QTL 11 18 2.8 3749 Spink1 45561 D18Wox18 45561 D18Wox18 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619656 11414700 18 37878841 82878841 4 - by one flank marker only 18 37135503 82135503 4 - by one flank marker only backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 18 38221919 83221919 4 - by one flank marker only 18 35870723 80870723 4 - by one flank marker only 631519 rat Pia11 Pristane induced arthritis QTL 11 1 5.3 13.0 38144 D1Rat185 10951 D1Mit13 34011 D1Mit2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2300074;1582387;2307198 12111642;18606636;16804090;18540828 recessive Pia14 (maps to same region);Pia9 (interacts with) 1 160649793 205649793 4 - by one flank marker only 1 83489176 186472032 2 - by one flank and peak markers Intercross E3xLEW.1F 61013 631581 E3 LEW.1F 1 153656062 198656062 4 - by one flank marker only 1 136830018 181830018 4 - by one flank marker only 631520 rat Bp73 Blood pressure QTL 73 2 1.0E-4 3098 Mme 10584 D2Wox18 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension;hypertension 631320;70380 12661916;11773968 70972 Hao2 Bp10 (interacts with);Bp19 (interacts with) 2 173193501 201402094 1 - by flanking markers 2 153031724 174727552 1 - by flanking markers intercross 631582 SS.WKY-(Mme-D2Wox18)/Mco 2 153799203 181987474 1 - by flanking markers 2 147686913 168355276 1 - by flanking markers 631521 rat Pia12 Pristane induced arthritis QTL 12 12 8.9 20.0 35384 D12Rat1 35889 D12Rat10 40986 D12Rat72 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2300074;1582387 12111642;18606636;16804090 recessive Pia4 (maps to same region) 12 6945260 28700508 1 - by flanking markers 12 555108 24748499 1 - by flanking markers Intercross E3xLEW.1F 61013 631581 E3 LEW.1F 12 23241246 26710128 2 - by one flank and peak markers 12 20259417 23672083 2 - by one flank and peak markers 631522 rat Bp74 Blood pressure QTL 74 2 0.05 34292 D2Mgh8 34234 D2Mgh9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70380 11773968 2 206015127 218191419 1 - by flanking markers 2 179302449 191378271 1 - by flanking markers intercross 631583 SS.WKY-(D2Mgh8-D2Mgh9)/Mco 2 186611811 198704485 1 - by flanking markers 2 172710921 184114403 1 - by flanking markers 631523 rat Pia13 Pristane induced arthritis QTL 13 14 3.3 8.0 34839 D14Rat32 35723 D14Rat25 37230 D14Rat64 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2300074;1582387;2307198 12111642;18606636;16804090;18540828 recessive 14 42238587 108554989 1 - by flanking markers 14 43399833 105009429 1 - by flanking markers Intercross LEW.1FxE3 61013 631581 E3 LEW.1F 14 42442731 108833671 1 - by flanking markers 14 40793460 98037301 1 - by flanking markers 631524 rat Bp75 Blood pressure QTL 75 16 0.05 35475 D16Rat21 42409 D16Rat112 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70460;1300037 11919686;15080379 Bp248 (sub_region) 16 773569 11086530 1 - by flanking markers 16 64959 8413129 1 - by flanking markers backcross 631585 1358168 SS.LEW-(D16Mit2-D16Rat12)/Ayd SS.LEW-(D16Mit2-D16Chm23)/Ayd 16 1 778655 4 - by one flank marker only 16 1 110831 4 - by one flank marker only 631525 rat Pia14 Pristane induced arthritis QTL 14 16 4.4 19.0 39390 D16Rat64 60771 D16Wox8 38428 D16Rat53 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2307198;2300074;1582387 12111642;18540828;18606636;16804090 recessive Pia11 (maps to same region) 16 58966446 88650497 1 - by flanking markers 16 59398206 88891349 1 - by flanking markers Intercross E3xLEW.1F 61013 631581 E3 LEW.1F 16 59285775 89248943 1 - by flanking markers 16 55711087 83402471 1 - by flanking markers 631526 rat Bp76 Blood pressure QTL 76 10 1.0E-4 66552 D10Mco1 34445 D10Mgh6 3185 Nos2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure;decreased systemic arterial blood pressure hypertension 619625;61039;619626 9607182;7537756;9096100 10 63366218 68786307 1 - by flanking markers 10 67678060 69986912 1 - by flanking markers backcross 10041 60992 SS/Jr MNS 10 64648311 69123603 1 - by flanking markers 10 61345413 66743655 1 - by flanking markers 631527 rat Tls1 T-lymphoma susceptibility QTL 1 5 0.0 0.001 33981 D5Mit4 11302 D5Mit7 11302 D5Mit7 thymus integrity trait (VT:0010555) post-insult time to onset of T-cell lymphoma (CMO:0001907) increased T cell derived lymphoma incidence T-cell non-Hodgkin lymphoma 619600 10360666 5 97315057 142315057 4 - by one flank marker only 5 94515803 139515803 4 - by one flank marker only backcross LE/StmxF344 70509 629500 F344/NRrrc LEXF/Stm 5 93273130 138273130 4 - by one flank marker only 5 90450144 135450144 4 - by one flank marker only 631528 rat Scl11 Serum cholesterol level QTL 11 14 4.9 60764 D14Wox4 2065 Afp 2667 Gc blood cholesterol amount (VT:0000180) blood total cholesterol level (CMO:0000051) increased circulating cholesterol level Hypercholesterolemia 619656 11414700 14 19067260 38099442 1 - by flanking markers 14 19110728 38152541 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 14 19159919 38289187 1 - by flanking markers 14 17573412 19726296 2 - by one flank and peak markers 631529 rat Tls2 T-lymphoma susceptibility QTL 2 7 0.0 0.001 11164 D7Wox24 33648 D7Mit5 33969 D7Mit4 thymus integrity trait (VT:0010555) percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911) increased T cell derived lymphoma incidence T-cell non-Hodgkin lymphoma 619600 10360666 7 88393619 120429563 2 - by one flank and peak markers 7 85090032 137838850 1 - by flanking markers backcross LE/StmxF344 70509 629500 F344/NRrrc LEXF/Stm 7 88365265 119318087 2 - by one flank and peak markers 7 80221299 109401111 2 - by one flank and peak markers 631530 rat Tls3 T-lymphoma susceptibility QTL 3 10 0.0 1.0E-4 34100 D10Mgh3 34669 D10Mgh20 34445 D10Mgh6 thymus integrity trait (VT:0010555) percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911) increased T cell derived lymphoma incidence T-cell non-Hodgkin lymphoma 619600 10360666 10 53376848 98640137 1 - by flanking markers 10 53781298 100090301 1 - by flanking markers backcross LE/StmxF344 70509 629500 F344/NRrrc LEXF/Stm 10 53625815 98939209 1 - by flanking markers 10 51774612 95600334 1 - by flanking markers 631531 rat Iresp2 Immunoglobin response QTL2 10 6.3 13.0 35001 D10Rat43 36179 D10Rat34 44715 D10Wox26 blood immunoglobulin E amount (VT:0002492) serum immunoglobulin E level (CMO:0002101) increased IgE level allergic disease 619646 10898507 additive 10 22266756 32523945 1 - by flanking markers 10 23428127 32725718 1 - by flanking markers intercross LEW/RjxBN/Rj 1331823 LEW.BN-(D10Rat43-D10Rat27)/Rj 10 22402817 38204229 2 - by one flank and peak markers 10 22918268 36400810 2 - by one flank and peak markers 631532 rat Cm50 Cardiac mass QTL 50 10 6.6 60753 D10Wox3 10949 D10Wox11 34053 D10Mit3 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight hypertension 619631 10051321 10 18130297 53388667 1 - by flanking markers 10 18217625 53793117 1 - by flanking markers intercross BN.SS/Jr 10041 60985 SS/Jr BN 10 18246394 53637634 1 - by flanking markers 10 17907113 51786432 1 - by flanking markers 631533 rat Iresp3 Immunoglobin response QTL3 9 16.2 31.0 34264 D9Mgh5 60669 D9Got8 blood immunoglobulin E amount (VT:0002492) serum immunoglobulin E level (CMO:0002101) increased IgE level allergic disease 619646;69712 10898507;10072499 additive Eae4 (maps to same region) 9 1 37250901 2 - by one flank and peak markers 9 2176482 5446654 2 - by one flank and peak markers intercross LEW/RjxBN/Rj 631593 631594 LEW/Rj BN/Rj 9 2005583 3309921 2 - by one flank and peak markers 9 2745799 5857951 2 - by one flank and peak markers 631534 rat Lnnr1 Liver neoplastic nodule remodeling QTL 1 7 3.85 0.001 36099 D7Rat25 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705) decreased liver tumor incidence Experimental Liver Neoplasms 629574;1358145 12672032;15771619 2185;2868;3130;3377 Avpr1a;Igf1;Myc;Ppp1cc 7 41096572 86096572 5 - by peak with adj size 7 38076588 83076588 5 - by peak with adj size BNxF344 60985 70509 BN F344/NRrrc 7 40872682 85872682 5 - by peak with adj size 7 34293282 79293282 5 - by peak with adj size 631535 rat Cm51 Cardiac mass QTL 51 10 3.0 10949 D10Wox11 44786 D10Wox6 44773 D10Wox5 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight hypertension 619631 10051321 10 53388518 98370512 2 - by one flank and peak markers 10 53792967 96584953 2 - by one flank and peak markers intercross MNS.SS/Jr 10041 60992 SS/Jr MNS 10 53637485 94807701 2 - by one flank and peak markers 10 51786282 91669536 2 - by one flank and peak markers 631536 rat Lnnr2 Liver neoplastic nodule remodeling QTL 2 1 2.9 5.0E-4 34194 D1Mgh14 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705) decreased liver tumor incidence Experimental Liver Neoplasms 629574;1358145 12672032;15771619 2056;2059;2456;1587390 Adra2a;Adrb1;Cyp17a1;Prkg1 recessive 1 263104834 290094216 5 - by peak with adj size 1 241199027 267910886 5 - by peak with adj size BNxF344 60985 70509 BN F344/NRrrc 1 255728828 282763074 5 - by peak with adj size 1 233948574 260522016 5 - by peak with adj size 631537 rat Oia4 Oil induced arthritis QTL 4 10 35513 D10Rat24 11137 D10Wox17 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 62404;2307198;2306769 11230175;18540828;19299744 Ean4 (maps to same region);Oia3 (maps to same region);Oia5 (maps to same region);Oia6 (interacts with) 10 78194957 89831596 1 - by flanking markers 10 79229067 91168491 1 - by flanking markers 631596 LEW.1AV1.DA-(D10Rat92-D10Wox17)/Ubc 10 78343027 90042115 1 - by flanking markers 10 75631887 87055282 1 - by flanking markers 631538 rat Oia5 Oil induced arthritis QTL 5 10 11137 D10Wox17 34128 D10Mgh1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 62404;2307198 11230175;18540828 Oia3 (maps to same region);Oia4 (maps to same region);Oia6 (maps to same region) 10 89831438 112200500 4 - by one flank marker only 10 91168332 110718848 4 - by one flank marker only 631597 LEW.1AV1.DA-(D10Wox17-D10Rat135)/Ubc 10 90041957 112626471 4 - by one flank marker only 10 87055121 107211142 4 - by one flank marker only 631539 rat Oia6 Oil induced arthritis QTL 6 10 44836 D10Got154 41584 D10Rat135 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 62404;2307198 11230175;18540828 Oia3 (maps to same region);Oia4 (interacts with);Oia5 (maps to same region) 10 100150192 108145987 1 - by flanking markers 10 101532360 108776963 1 - by flanking markers 631598 LEW.1AV1.DA-(D10Got154-D10Rat135)/Ubc 10 100460820 108540162 1 - by flanking markers 10 97010147 104670812 1 - by flanking markers 631540 rat Bw9 Body weight QTL 9 7 4.5 10075 D7Mgh2 34499 D7Mgh7 10937 D7Wox15 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619631 10051321 7 77531259 128787635 2 - by one flank and peak markers 7 74244786 123665486 2 - by one flank and peak markers intercross BN.SS/Jr 10041 60985 SS/Jr BN 7 77428105 127748511 2 - by one flank and peak markers 7 69736226 117455174 2 - by one flank and peak markers 631541 rat Bp81 Blood pressure QTL 81 3 4.0 10668 D3Wox4 43691 D3Wox20 34316 D3Mgh2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased heart weight;increased systemic arterial blood pressure hypertension 619631 10051321 3 136268218 183740530 2 - by one flank and peak markers 3 124893448 171063335 2 - by one flank and peak markers intercross BNxSS/Jr 10041 60985 SS/Jr BN 3 129787213 177699992 2 - by one flank and peak markers 3 124122556 169034231 2 - by one flank and peak markers 631542 rat Bp82 Blood pressure QTL 82 10 6.8 33632 D10Mit10 44839 D10Wox7 11479 D10Mit8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased heart weight;increased systemic arterial blood pressure hypertension 619631 10051321 10 27082535 102101375 1 - by flanking markers 10 27184741 103551039 1 - by flanking markers intercross MNSxSS/Jr 10041 60992 SS/Jr MNS 10 27237530 102427718 1 - by flanking markers 10 26521957 98952741 1 - by flanking markers 631543 rat Bp83 Blood pressure QTL 83 12 5.8 45014 D12Wox8 33776 D12Mit3 60755 D12Wox16 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619631 10051321 12 19226299 45929887 2 - by one flank and peak markers 12 16535858 39626712 2 - by one flank and peak markers intercross MNSxSS/Jr 10041 61103 SS/Jr WKY 12 17185580 44098244 2 - by one flank and peak markers 12 15550826 38478808 2 - by one flank and peak markers 631544 rat Bp84 Blood pressure QTL 84 1 5.6 21.0 60784 D1Wox29 3750 Spn 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal baroreceptor physiology;increased systemic arterial blood pressure hypertension 619634;2302408;1302892 10604486;19047583;15480093 Cstrr1 (sub_region) 1 131822204 205576290 1 - by flanking markers 1 124614679 186391887 1 - by flanking markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 1 130779148 198585664 1 - by flanking markers 1 123350408 181759564 1 - by flanking markers 631545 rat Bp85 Blood pressure QTL 85 3 3.1 34198 D3Mgh8 34347 D3Mgh16 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619634 10604486 3 1 33861758 5 - by peak with adj size 3 1 28873394 5 - by peak with adj size intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 3 1 28500807 5 - by peak with adj size 3 1 33278763 5 - by peak with adj size 631546 rat Bp86 Blood pressure QTL 86 4 3.2 33757 D4Mit2 33905 D4Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619634 10604486 4 55539015 157291359 1 - by flanking markers 4 55369931 91330856 1 - by flanking markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 4 55791564 92484312 1 - by flanking markers 4 57114432 91360801 1 - by flanking markers 631547 rat Bp87 Blood pressure QTL 87 10 4.5 34128 D10Mgh1 34485 D10Mgh4 33941 D10Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619634 10604486 10 50372987 95372987 4 - by one flank marker only 10 96799833 106897319 2 - by one flank and peak markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 10 50638337 95638337 4 - by one flank marker only 10 47369470 92369470 4 - by one flank marker only 631548 rat Bp88 Blood pressure QTL 88 1 5.0 0.001 36105 D1Rat51 3640 Scnn1b 631293 D1M7Mit236 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 619643 10523340 Bp30 (maps to same region) 1 173583273 198953453 1 - by flanking markers 1 159782445 180748068 1 - by flanking markers intercross WKYxSHRSP 631600 WKY.SHRSP-(Mt1pa-D1Rat200)/Bbb 1 167394665 191883991 1 - by flanking markers 1 156677124 176484451 1 - by flanking markers 631549 rat Bp89 Blood pressure QTL 89 1 5.7 36580 D1Rat112 60784 D1Wox29 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619635 10779121 1 131822376 226109127 1 - by flanking markers 1 124614852 206574205 1 - by flanking markers backcross WKYxSHRSP 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb 1 130779320 219238476 1 - by flanking markers 1 123350581 201284552 1 - by flanking markers 631550 rat Bw7 Body weight QTL 7 15 3.6 36313 D15Rat5 40674 D15Rat86 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 629577 12482837 15 24970714 44894842 1 - by flanking markers 15 22452603 39869843 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 15 21021342 41082727 1 - by flanking markers 15 19856566 34924750 1 - by flanking markers 631551 rat Vetf1 Vascular elastic tissue fragility QTL 1 5 5.0 1.0E-4 37784 D5Rat59 37596 D5Rat118 39686 D5Rat119 aorta elastic tissue integrity trait (VT:0010556) artery internal elastic lamina non-tumorous lesion count (CMO:0001913) abnormal susceptibility to atherosclerosis atherosclerosis 619605;8662443 11526202;17356016 621017 Lyn Vetf3 (maps to same region) 5 1662934 10373154 1 - by flanking markers 5 1368223 5112800 1 - by flanking markers BN/PitxGH/Omr 10016 631602 GH/Omr BN/Elh 5 1666587 5533324 1 - by flanking markers 5 2282226 5904428 1 - by flanking markers 631552 rat Vetf2 Vascular elastic tissue fragility QTL 2 10 4.5 2.0E-4 34318 D10Mgh10 10466 D10Mit1 33846 D10Mit2 aorta elastic tissue integrity trait (VT:0010556) artery internal elastic lamina non-tumorous lesion count (CMO:0001913) abnormal susceptibility to atherosclerosis atherosclerosis 619605;8662443 11526202;17356016 3742 Sparc dominant Vetf10 (maps to same region) 10 35954931 93929812 1 - by flanking markers 10 36254741 95369088 1 - by flanking markers BN/PitxGH/Omr 10016 631602 GH/Omr BN/Elh 10 36185929 95845311 2 - by one flank and peak markers 10 41142633 86142633 5 - by peak with adj size 631554 rat Bp133 Blood pressure QTL 133 10 0.005 3136 Myh11 3185 Nos2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619633;2312779 7568016;15800376 dominant Bp1 (maps to same region) 10 11444263 65456957 1 - by flanking markers 10 666709 65072453 1 - by flanking markers backcross WKYxSHRSP 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb 10 764421 66221621 1 - by flanking markers 10 743364 63851208 1 - by flanking markers 631555 rat Bp134 Blood pressure QTL 134 10 0.001 3177 Ngfr 2686 Gh1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619633;2312779 7568016;15800376 dominant Bp1 (maps to same region) 10 83198396 94239391 1 - by flanking markers 10 84262804 95694117 1 - by flanking markers backcross WKYxSHRSP 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb 10 83389828 94488181 1 - by flanking markers 10 80515287 91230079 1 - by flanking markers 631556 rat Bp135 Blood pressure QTL 135 4 0.017 3197 Npy 3753 Spr 3197 Npy arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 631181 8476428 dominant 4 144233753 181496612 1 - by flanking markers 4 78038013 119369308 1 - by flanking markers intercross WKY/SnkxSHR/Snk 631603 631604 WKY/Snk SHR/Snk 4 79557856 116916073 1 - by flanking markers 4 78881294 117676292 1 - by flanking markers 631557 rat Bp136 Blood pressure QTL 136 10 0.003 66469 D10Mco58 35513 D10Rat24 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 628510;1643425 11641286;18175179 3185 Nos2 10 33195122 78195122 4 - by one flank marker only 10 34229233 79229233 4 - by one flank marker only Intercross 631605 SS.LEW-(D10Arb9-D10Got101)/Jr 10 33343192 78343192 4 - by one flank marker only 10 30632053 75632053 4 - by one flank marker only 631558 rat Bp137 Blood pressure QTL 137 10 0.013 35627 D10Rat12 66520 D10Mco70 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 628510 11641286 10 97758850 99977168 1 - by flanking markers 10 99198838 101355916 1 - by flanking markers Intercross 631606 SS.MNS-(D10Rat13-D10Mit11)/Jr 10 98044675 100287699 1 - by flanking markers 10 94724860 96836268 1 - by flanking markers 631559 rat Hcuc1 Hepatic copper content QTL 1 10 3.0 liver copper amount (VT:0003065) liver copper weight to liver dry weight ratio (CMO:0001512) increased liver copper level Wilson disease;liver disease 619607;629572 11741328;12094018 621684 Atox1 Hcuc4 (maps to same region) SHR/OlaIpcv||BN-Lx/Cub 68049 HXB-1-43/Ipcv 631560 rat Apr1 Acute phase response QTL 1 12 6.1 11396 D12Mgh11 orosomucoid 1 amount (VT:0010541) plasma orosomucoid 1 level (CMO:0001467) abnormal acute phase protein level rheumatoid arthritis 629561;2300074;1582387;2307198;2302026 11817600;18606636;16804090;18540828;14674011 recessive Pia37 (maps to same region) 12 26700760 54450796 5 - by peak with adj size 12 20418353 46782294 5 - by peak with adj size E3xDA 60997 61013 DA E3 12 24906590 52716770 5 - by peak with adj size 12 19144362 46669029 5 - by peak with adj size 631561 rat Hcuc2 Hepatic copper content QTL 2 16 2.8 10885 D16Wox9 liver copper amount (VT:0003065) liver total copper weight (CMO:0001507) increased liver copper level Wilson disease;liver disease 619607 11741328 16 1 41109553 5 - by peak with adj size 16 1 40096622 5 - by peak with adj size SHR/OlaIpcvxBN-Lx/Cub 68049 HXB-1-43/Ipcv 16 1 41240957 5 - by peak with adj size 16 1 39533949 5 - by peak with adj size 631562 rat Apr2 Acute phase response QTL 2 5 3.7 11001 D5Wox10 blood murinoglobulin 1 amount (VT:0010597) plasma murinoglobulin 1 level (CMO:0001931) abnormal acute phase protein level rheumatoid arthritis 629561;2300074;1582387;2307198 11817600;18606636;16804090;18540828 dominant 5 145965224 177180328 5 - by peak with adj size 5 142573432 173096209 5 - by peak with adj size E3xDA 60997 61013 DA E3 5 142307322 173707219 5 - by peak with adj size 5 135927956 166875058 5 - by peak with adj size 631563 rat Hcuc3 Hepatic copper content QTL 3 2 3.87 37552 D2Rat185 40128 D2Rat241 liver copper amount (VT:0003065) liver copper weight to liver dry weight ratio (CMO:0001512) increased liver copper level Wilson disease;liver disease 629572 12094018 2838 Hsd3b5 recessive 2 242993417 264423632 1 - by flanking markers 2 217985582 238139978 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 2 245893572 266435125 4 - by one flank marker only 2 229059610 249053267 4 - by one flank marker only 631564 rat Apr3 Acute phase response QTL 3 10 3.9 10794 D10Mgh9 blood interleukin-6 amount (VT:0008595) plasma interleukin-6 level (CMO:0001927) abnormal circulating interleukin-6 level rheumatoid arthritis 629561 11817600 additive 10 16250463 61250463 5 - by peak with adj size 10 16579339 61579339 5 - by peak with adj size E3xDA 60997 61013 DA E3 10 16468736 61468736 5 - by peak with adj size 10 15275955 60275955 5 - by peak with adj size 631565 rat Hcuc4 Hepatic copper content QTL 4 10 4.15 36203 D10Rat27 38936 D10Rat98 liver copper amount (VT:0003065) liver copper weight to liver dry weight ratio (CMO:0001512) increased liver copper level Wilson disease;liver disease 629572 12094018 621684 Atox1 recessive Hcuc1 (maps to same region) 10 68983854 74127825 1 - by flanking markers 10 70191595 77091834 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 10 69348459 75983662 1 - by flanking markers 10 66941813 73452992 1 - by flanking markers 631566 rat Bp90 Blood pressure QTL 90 2 1.0E-4 61323 D2N35 3098 Mme arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619640 9541488 2 128278946 173278946 4 - by one flank marker only 2 108114515 153114515 4 - by one flank marker only backcross SS/JrxWKY 631607 SS.WKY-(D2N35-Mme)/Mco 2 108880910 153880910 4 - by one flank marker only 2 102803808 147803808 4 - by one flank marker only 631567 rat Bp91 Blood pressure QTL 91 10 1.0E-4 631289 D10M11Mit119 33941 D10Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619640 9541488 10 55446730 100446730 4 - by one flank marker only 10 56848683 101848683 4 - by one flank marker only backcross SS/JrxMNS 629505 SS.MNS-(D10Mit11-D10M11Mit119)/Mco 631568 rat Bp92 Blood pressure QTL 92 3 2.2 0.005 9.8 35609 D3Rat53 35947 D3Rat45 35609 D3Rat53 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61516 11015598 additive 3 1 40956181 5 - by peak with adj size 3 1 38709732 4 - by one flank marker only intercross SS/JrxSHR 10041 724574 SS/Jr SHR/NHsd 3 13126914 41510346 1 - by flanking markers 3 1 39874793 5 - by peak with adj size 631569 rat Bp93 Blood pressure QTL 93 1 1.0E-4 34381 D1Mgh7 66611 D1Mco36 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 68885;9685377;2291850 11160999;25231251;18324438 additive Bp27 (interacts with);Bp30 (interacts with) 1 114600888 130268180 1 - by flanking markers 1 106445165 122992360 1 - by flanking markers intercross SSxLEW 728165 SS.LEW-(D1Rat196-D1Mco36)/Jr 1 113593576 129209407 1 - by flanking markers 1 106047847 121834139 1 - by flanking markers 631570 rat Bp94 Blood pressure QTL 94 1 1.0E-4 36432 D1Rat35 38296 D1Rat131 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 68885;2291850 11160999;18324438 additive Bp27 (interacts with);Bp30 (interacts with);Bp313 (sub_region);Bp314 (sub_region) 1 131958920 159182239 1 - by flanking markers 1 124748920 145648920 1 - by flanking markers backcross SSxLEW 631610 SS.LEW-(D1Rat39-D1Rat131)/Jr 1 130917121 152871103 1 - by flanking markers 1 123479780 142990467 1 - by flanking markers 631642 rat Stl2 Serum triglyceride level QTL 2 4 3.3 33656 D4Mit9 2901 Il6 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 619667 9633608 4 3100112 55067578 1 - by flanking markers 4 461376 54828069 1 - by flanking markers SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 4 3047807 55324857 1 - by flanking markers 4 5219178 56647776 1 - by flanking markers 631643 rat Bp120 Blood pressure QTL 120 9 3.0 0.004 1334445 D9Wox18 33842 D9Mit6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 9 24554204 69554204 4 - by one flank marker only 9 1526958 18347599 1 - by flanking markers SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 9 25692373 70692373 4 - by one flank marker only 9 22071200 67071200 4 - by one flank marker only 631645 rat Bp121 Blood pressure QTL 121 13 3.3 34351 D13Mgh4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 13 24916143 69916143 5 - by peak with adj size 13 15989872 60989872 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 13 19810814 64810814 5 - by peak with adj size 13 14915655 59915655 5 - by peak with adj size 631646 rat Stl4 Serum triglyceride level QTL 4 4 6.5 1.0E-4 17.9 33711 D4Mit5 34001 D4Mit17 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating insulin level;increased circulating triglyceride level Hypertriglyceridemia;hyperinsulinism 631174 12687333 4 138480612 196943890 1 - by flanking markers 4 72160227 134858710 1 - by flanking markers intercross hHTGxBN 1302795 1354669 HTG BN/OrlIcoCrlf 4 73786419 132455556 1 - by flanking markers 4 73169846 132642728 1 - by flanking markers 631647 rat Bp122 Blood pressure QTL 122 3 6.2 34146 D3Mgh6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 3 38749889 83749889 5 - by peak with adj size 3 28022667 73022667 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 3 32130997 77130997 5 - by peak with adj size 3 30684642 75684642 5 - by peak with adj size 631648 rat Stl5 Serum triglyceride level QTL 5 8 4.0 3.0E-4 41522 D8Rat164 44441 D8Wox3 33913 D8Mit13 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia 631174 12687333 additive 8 29878681 62336643 2 - by one flank and peak markers 8 28414004 58991068 2 - by one flank and peak markers intercross hHTGxBN 1302795 1354669 HTG BN/OrlIcoCrlf 8 29867983 59908353 2 - by one flank and peak markers 8 27205715 54998217 2 - by one flank and peak markers 631649 rat Bp123 Blood pressure QTL 123 3 3.2 34250 D3Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 3 101312247 146312247 5 - by peak with adj size 3 89819539 134819539 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 3 94788365 139788365 5 - by peak with adj size 3 89772419 134772419 5 - by peak with adj size 631650 rat Stl6 Serum triglyceride level QTL 6 8 4.0 0.0019 36235 D8Rat35 34180 D8Mgh1 34415 D8Mgh6 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia 631174 12687333 additive 8 65325025 119835296 1 - by flanking markers 8 64616911 116844692 1 - by flanking markers intercross hHTGxBN 1302795 1354669 HTG BN/OrlIcoCrlf 8 10938911 120496129 2 - by one flank and peak markers 8 10378157 112202585 2 - by one flank and peak markers 631651 rat Bp124 Blood pressure QTL 124 4 3.0 35409 D4Rat34 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 4 128590766 173590766 5 - by peak with adj size 4 62514126 107514126 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 4 63938412 108938412 5 - by peak with adj size 4 62879517 107879517 5 - by peak with adj size 631652 rat Bp106 Blood pressure QTL 106 10 3671 Shbg 2171 Atp1b2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629620 12566390 10 55957510 55965499 1 - by flanking markers 10 56424465 56432474 1 - by flanking markers 728139 WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb 10 56211879 56219861 1 - by flanking markers 10 54324933 54332939 1 - by flanking markers 631653 rat Bp125 Blood pressure QTL 125 8 3.3 33895 D8Mit1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 8 72350448 117350448 5 - by peak with adj size 8 70474667 115474667 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 8 72849686 117849686 5 - by peak with adj size 8 66142385 111142385 5 - by peak with adj size 631654 rat Bp107 Blood pressure QTL 107 1 37428 D1Rat200 39314 D1Rat216 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629620 12566390 1 134116233 205161264 1 - by flanking markers 1 126938969 185923619 1 - by flanking markers 631694 728139 WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb 1 133076978 178076978 4 - by one flank marker only 1 125611501 170611501 4 - by one flank marker only 631655 rat Bp126 Blood pressure QTL 126 15 4.0 2536 Ednrb arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 15 69016189 114016189 5 - by peak with adj size 15 65395920 109758846 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 15 65520564 110520564 5 - by peak with adj size 15 58156477 101769107 5 - by peak with adj size 631656 rat Bp108 Blood pressure QTL 108 9 5.97 1.0E-4 36556 D9Rat10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629621;2302803 12775577;18854752 Bp333 (maps to same region);Bp334 (interacts with) 9 53957431 98957431 5 - by peak with adj size 9 45992963 90992963 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 9 54177542 99177542 5 - by peak with adj size 9 48598251 93598251 5 - by peak with adj size 631658 rat Cm7 Cardiac mass QTL 7 1 5.32 1.0E-4 36866 D1Rat73 aorta mass (VT:0002845) aorta weight (CMO:0000076) abnormal aortic weight heart disease;hypertension 629621 12775577 1 223613389 268613389 5 - by peak with adj size 1 201920676 246920676 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 1 216324817 261324817 5 - by peak with adj size 1 196248093 241248093 5 - by peak with adj size 631660 rat Hcar1 Hepatocarcinoma resistance QTL 1 10 3.4 1.0E-4 34318 D10Mgh10 38062 D10Rat96 36542 D10Rat51 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms 619598 10493520 3112;3889 Abcc1;Tp53 dominant 10 5044836 35954931 1 - by flanking markers 10 6172805 36254741 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 10 6229289 36185929 1 - by flanking markers 10 6154182 15990232 2 - by one flank and peak markers 631662 rat Hcar2 Hepatocarcinoma resistance QTL 2 4 3.1 3.0E-4 11011 D4Mgh4 36554 D4Rat47 35817 D4Rat40 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms 619598 10493520 2794;3082;3849 Hgf;Met;Tgfa 4 144230964 187610582 2 - by one flank and peak markers 4 78035196 135074488 2 - by one flank and peak markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 4 79555067 124555067 4 - by one flank marker only 4 78878504 123878504 4 - by one flank marker only 631663 rat Bw6 Body weight QTL 6 7 3.4 39048 D7Rat94 35921 D7Rat12 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 629577 12482837 7 120739452 143465961 1 - by flanking markers 7 142816042 143002779 4 - by one flank marker only BC/CpbuxLew/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 7 120746024 145692398 1 - by flanking markers 7 111075573 134976056 1 - by flanking markers 631664 rat Hcar3 Hepatocarcinoma resistance QTL 3 8 2.9 5.0E-4 36161 D8Rat36 11222 D8Mgh3 34870 D8Rat18 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms 619598 10493520 2458;2459;3845 Cyp1a1;Cyp1a2;Tf 8 57006784 105968579 1 - by flanking markers 8 57308572 103684785 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 8 58425510 106526740 1 - by flanking markers 8 54237644 99103503 1 - by flanking markers 631665 rat Bw8 Body weight QTL 8 3 5.5 11499 D3Wox23 11261 D3Wox9 34242 D3Mgh13 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619631 10051321 3 58456486 131007629 1 - by flanking markers 3 47722628 119673738 1 - by flanking markers intercross MNS.SS/Jr 10041 60992 SS/Jr MNS 3 51821836 124513579 1 - by flanking markers 3 50437042 119183768 1 - by flanking markers 631666 rat Iddm5 Insulin dependent diabetes mellitus QTL 5 X 3415 Prps2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 625443 8586150 X 6350189 51350189 5 - by peak with adj size X 24794818 69794818 5 - by peak with adj size 60997 61107 DA BB/OK X 5954078 50954078 5 - by peak with adj size X 4494549 49494549 5 - by peak with adj size 631667 rat Iddm6 Insulin dependent diabetes mellitus QTL 6 1 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 625443 8586150 60997 61107 DA BB/OK 631668 rat Iddm7 Insulin dependent diabetes mellitus QTL 7 X blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 631165 9080298 BB-DP/HrixBN/Mol 631697 631698 BBDP/Hri BN/Mol 631669 rat Iddm9 Insulin dependent diabetes mellitus QTL 9 1 2.8 0.039 10674 D1Mgh12 33844 D1Mit14 10805 D1Mgh13 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 61077;6903877;2303106 9571179;9858659;19168599 Iddm25 (maps to same region) 1 270716905 287992330 1 - by flanking markers 1 247322146 266002939 1 - by flanking markers backcross BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 1 252955158 280632620 2 - by one flank and peak markers 1 233190394 258625266 2 - by one flank and peak markers 631670 rat Iddm10 Insulin dependent diabetes mellitus QTL 10 1 1.9 62086 Acsm3 3643 Sct 3750 Spn blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 6903877;2303106 9858659;19168599 Iddm25 (maps to same region) 1 196449042 221191992 1 - by flanking markers 1 178054386 201472944 1 - by flanking markers BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 1 189514504 214277437 1 - by flanking markers 1 174133260 196383668 1 - by flanking markers 631671 rat Iddm11 Insulin dependent diabetes mellitus QTL 11 4 3.6 0.0012 43795 D4Wox10 11012 D4Wox22 33711 D4Mit5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level;insulitis;pancreas inflammation Chronic Pancreatitis;Experimental Diabetes Mellitus 61480;1600776;1358925 9892222;17376830;14727142 Iddm14 (maps to same region) 4 57068808 144252646 1 - by flanking markers 4 56920444 78042833 1 - by flanking markers (WF/CrCrl x BBDP/WorBrm)x WF/CrCrl 1642018 2311079 BBDP/WorBrm WF/CrCrl 4 57307075 79578854 1 - by flanking markers 4 58635877 78886137 1 - by flanking markers 631672 rat Iddm12 Insulin dependent diabetes mellitus QTL 12 13 2.2 0.0032 33923 D13Mit1 34371 D13Mgh3 34076 D13Mgh1 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level Experimental Diabetes Mellitus 61480 9892222 2199 Bcl2 13 14281836 44494565 1 - by flanking markers 13 25430110 35472503 1 - by flanking markers (WF/CrCrl x BBDP/WorBrm)x WF/CrCrl 1642018 2311079 BBDP/WorBrm WF/CrCrl 13 9016742 39373058 1 - by flanking markers 13 5994668 34535351 1 - by flanking markers 631673 rat Iddm13 Insulin dependent diabetes mellitus QTL 13 3 1.3 0.663 33808 D3Mit4 34240 D3Mgh1 10502 D3Mgh10 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level Experimental Diabetes Mellitus 61480;2296064 9892222;18453595 Eau4 (maps to same region) 3 143321230 176999932 1 - by flanking markers 3 131188558 163778754 1 - by flanking markers (WF/CrCrl x BBDP/WorBrm)x WF/CrCrl 1642018 2311079 BBDP/WorBrm WF/CrCrl 3 136876155 170935007 1 - by flanking markers 3 130193298 161695983 1 - by flanking markers 631674 rat Iddm14 Insulin dependent diabetes mellitus QTL 14 4 42164 D4Arb29 10524 D4Mit3 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 61479;1358925;2305928;1600776;1358924;1304485;61480;2313174 10535446;14727142;19205800;17376830;15793267;12401717;9892222;19720792 Iddm11 (maps to same region);Iddm37 (interacts with) 4 63250011 224304222 1 - by flanking markers 4 63276741 160891592 1 - by flanking markers BB/DRxWF 1641868 WF.BBDR-(D4Rat93-D4Rat228)/Wor 4 63537179 157286626 1 - by flanking markers 4 64528739 157573521 1 - by flanking markers 631675 rat Iddm15 Insulin dependent diabetes mellitus QTL 15 18 2715 Gnal 33814 D18Mit9 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) decreased circulating glucose level;decreased urine glucose level diabetes mellitus 619685 11327715 18 61991738 79748387 1 - by flanking markers 18 63595606 80370517 1 - by flanking markers BB/OKxSHR 631700 BB.SHR-(Gnal-D18Mit9)/K 18 62805406 80696375 1 - by flanking markers 18 60622311 77209844 1 - by flanking markers 631676 rat Cm8 Cardiac mass QTL 8 3 7.03 1.0E-4 34336 D3Mgh7 aorta mass (VT:0002845) aorta weight (CMO:0000076) abnormal aortic weight heart disease;hypertension 629621 12775577 3 23109820 68109820 5 - by peak with adj size 3 14056777 59056777 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 3 18023664 63023664 5 - by peak with adj size 3 16954708 61954708 5 - by peak with adj size 631677 rat Iddm16 Insulin dependent diabetes mellitus QTL 16 6 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 61077 9571179 backcross BB/OKxDA 60997 61107 DA BB/OK 631678 rat Cm9 Cardiac mass QTL 9 19 4.27 1.0E-4 35567 D19Rat18 aorta mass (VT:0002845) aorta weight (CMO:0000076) abnormal aortic weight heart disease;hypertension 629621 12775577 Cm12 (maps to same region) 19 1 29550005 5 - by peak with adj size 19 1 29295214 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 19 1 29558305 5 - by peak with adj size 19 1 28982497 5 - by peak with adj size 631679 rat Cm10 Cardiac mass QTL 10 3 7.34 1.0E-4 34186 D3Mgh9 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy;hypertension 629621 12775577 3 1 31148083 5 - by peak with adj size 3 1 26510302 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 3 1 25786001 5 - by peak with adj size 3 1 31158234 5 - by peak with adj size 631680 rat Cm11 Cardiac mass QTL 11 9 3.1 8.9E-4 39812 D9Rat125 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy;hypertension 629621 12775577 9 24567770 69567770 5 - by peak with adj size 9 17330701 62330701 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 9 24885099 69885099 5 - by peak with adj size 9 20430519 65430519 5 - by peak with adj size 631681 rat Cm12 Cardiac mass QTL 12 19 3.33 5.3E-4 35567 D19Rat18 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy;hypertension 629621;1600252;2307185 12775577;17143179;18824493 Cm9 (maps to same region) 19 1 29550005 5 - by peak with adj size 19 1 29295214 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 19 1 29558305 5 - by peak with adj size 19 1 28982497 5 - by peak with adj size 631682 rat Bp115 Blood pressure QTL 115 2 4.3 1.0E-4 66484 D2Uia17 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629622 12473864 2845;3043;3329;69413 Htr1a;Map1b;Pik3r1;Rasgrf2 additive 2 1 35028452 5 - by peak with adj size 2 1 35849844 5 - by peak with adj size SS/JrxAS 10041 67958 SS/Jr AS 2 1 35167060 5 - by peak with adj size 2 1 37410502 5 - by peak with adj size 631683 rat Bp116 Blood pressure QTL 116 4 1.0E-4 36143 D4Rat60 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629622 12473864 2042;2096;2256;2360;2933;2949;3371;3418;3826;62017;621141 Add2;Alox5;Cald1;Clcn1;Itpr1;Kcna1;Pparg;Prss2;Tbxas1;Pebp1;Wnk1 dominant 4 186408226 231408226 5 - by peak with adj size 4 127060280 172060280 5 - by peak with adj size SS/JrxAS 10041 67958 SS/Jr AS 4 123111827 168111827 5 - by peak with adj size 4 124303370 169303370 5 - by peak with adj size 631684 rat Bp117 Blood pressure QTL 117 1 8.3 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 1 119421009 164421009 3 - by peak only 1 112480604 157480604 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 631685 rat Bp118 Blood pressure QTL 118 3 3.2 37166 D3Rat110 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 3 31324797 76324797 5 - by peak with adj size 3 20229699 65229699 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 3 24655225 69655225 5 - by peak with adj size 631686 rat Bp119 Blood pressure QTL 119 5 3.8 11072 D5Mgh2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 16 39315759 84315759 3 - by peak only 5 1 40017184 3 - by peak only SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 631687 rat Hcas1 Hepatocarcinoma susceptibility QTL 1 7 3.9 0.001 36193 D7Rat3 34555 D7Mgh6 37802 D7Rat78 liver integrity trait (VT:0010547) liver tumorous lesion volume to total liver volume ratio (CMO:0001082) increased hepatocellular carcinoma incidence Experimental Liver Neoplasms 619598 10493520 3130 Myc dominant 7 100740273 143501887 2 - by one flank and peak markers 7 96649133 137404381 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 7 100160423 140335001 1 - by flanking markers 7 91412594 129807172 1 - by flanking markers 631688 rat Hcas2 Hepatocarcinoma susceptibility QTL 2 1 3.0 1.0E-4 43175 D1Mgh16 35166 D1Rat33 34433 D1Mgh3 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) increased hepatocellular carcinoma incidence Experimental Liver Neoplasms 619598 10493520 dominant 1 7306799 123747809 1 - by flanking markers 1 6253946 116153262 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 1 5655769 122614963 1 - by flanking markers 1 5925874 115540829 1 - by flanking markers 631689 rat Scl4 Serum cholesterol level QTL 4 4 1.9 0.008 3753 Spr blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 619667 9633608 4 158994747 203994747 5 - by peak with adj size 4 96867443 141867443 5 - by peak with adj size SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 4 94414208 139414208 5 - by peak with adj size 4 95174120 140174120 5 - by peak with adj size 631690 rat Scl5 Serum cholesterol level QTL 5 1 2.1 33844 D1Mit14 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating triglyceride level Hypercholesterolemia;Hypertriglyceridemia 619667 9633608 1 265492278 290094216 5 - by peak with adj size 1 243502887 267910886 5 - by peak with adj size SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 1 258132568 282763074 5 - by peak with adj size 1 236125214 260522016 5 - by peak with adj size 631827 rat Alc4 Alcohol consumption QTL 4 5 3.5 3.0 40718 D5Rat120 39756 D5Rat123 34387 D5Mgh17 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;724636;731212 10979603;12960747;14634485 additive Alc10 (interacts with);Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc9 (interacts with) 5 12694705 23381659 1 - by flanking markers 5 10517466 18944220 2 - by one flank and peak markers Intercross HDA1 x LDA1, HAD2 x LAD2;HAD2xLAD2 631844 631845 Iusm:HAD1 Iusm:LAD1 5 7875611 18592319 1 - by flanking markers 5 8187501 18616199 1 - by flanking markers 631828 rat Alc5 Alcohol consumption QTL 5 10 2.4 2.0 34361 D10Mgh25 41276 D10Rat182 34361 D10Mgh25 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;724636;4890458;731212;7401255 10979603;12960747;20705418;14634485;23596094 2401;61836;1304560;1311614;1359733;1563691 Crebbp;Clcn7;Fahd1;Gnptg;Trap1;Mapk8ip3 additive Alc10 (interacts with);Alc11 (interacts with);Alc12 (maps to same region);Alc13 (interacts with);Alc9 (maps to same region);Foco17 (maps to same region) 10 4040517 17443406 1 - by flanking markers 10 5090008 17515458 1 - by flanking markers Intercross;intercross HAD1xLAD1;HAD2xLAD2 631844 631845 Iusm:HAD1 Iusm:LAD1 10 5217199 17555534 1 - by flanking markers 10 5144027 17245662 1 - by flanking markers 631829 rat Alc6 Alcohol consumption QTL 6 12 4.7 4.0 41626 D12Rat93 34389 D12Mgh10 36490 D12Rat18 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;731212;7401255 10979603;14634485;23596094 additive Alc10 (maps to same region);Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc9 (interacts with);Foco19 (maps to same region);Foco6 (maps to same region) 12 34202298 45143158 1 - by flanking markers 12 29675888 39018219 1 - by flanking markers intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 12 32289782 43305579 1 - by flanking markers 12 28607526 37691617 1 - by flanking markers 631830 rat Alc7 Alcohol consumption QTL 7 16 2.9 33848 D16Mit2 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;724636;731212 10979603;12960747;14634485 additive Alc10 (interacts with);Alc11 (maps to same region);Alc12 (interacts with);Alc13 (maps to same region);Alc9 (interacts with) 16 1 27496499 5 - by peak with adj size 16 1 26804456 5 - by peak with adj size Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 16 1 27556253 5 - by peak with adj size 16 1 26727669 5 - by peak with adj size 631831 rat Alc8 Alcohol consumption QTL 8 3 2.7 33782 D3Mit10 38148 D3Rat82 33782 D3Mit10 consumption behavior trait (VT:0002069) calculated ethanol drink intake rate (CMO:0001615) alcohol preference alcohol use disorder 631229;731212 11958543;14634485 Alc10 (interacts with);Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc9 (interacts with) 3 1 38138699 4 - by one flank marker only 3 1 29749474 4 - by one flank marker only Intercross W 634380 634381 iP/Iusm iNP/Iusm 3 1 32972944 4 - by one flank marker only 3 1 33230976 4 - by one flank marker only 631832 rat Sach1 Saccharin preference QTL 1 3 2.7 0.02 3.3 37010 D3Rat49 36472 D3Rat44 36047 D3Rat46 consumption behavior trait (VT:0002069) calculated saccharin drink intake volume (CMO:0001600) saccharin preference;saccharin preference alcohol use disorder 631229 11958543 3 33340297 50884810 1 - by flanking markers 3 23762471 41420436 1 - by flanking markers Intercross W 634380 634381 iP/Iusm iNP/Iusm 3 28136728 45772990 1 - by flanking markers 3 27494621 44188411 1 - by flanking markers 631833 rat Sach2 Saccharin preference QTL 2 16 4.0 0.01 5.0 34066 D16Mgh1 37054 D16Rat17 34553 D16Mgh6 consumption behavior trait (VT:0002069) calculated saccharin drink intake rate (CMO:0001613) saccharin preference;saccharin preference 631229 11958543 additive 16 45651035 52968648 1 - by flanking markers 16 46137355 53486191 1 - by flanking markers Intercross W 634380 634381 iP/Iusm iNP/Iusm 16 45905097 53253355 1 - by flanking markers 16 43024842 50166018 1 - by flanking markers 631834 rat Sach3 Saccharin preference QTL 3 18 3.9 0.01 3.0 39000 D18Rat61 34975 D18Rat13 39000 D18Rat61 consumption behavior trait (VT:0002069) calculated saccharin drink intake volume (CMO:0001600) saccharin preference;saccharin preference 631229 11958543 recessive 18 60167906 67678102 1 - by flanking markers 18 61571526 66720186 1 - by flanking markers Intercross W 634380 634381 iP/Iusm iNP/Iusm 18 60971508 68524999 1 - by flanking markers 18 58805687 63636873 1 - by flanking markers 631835 rat Scl67 Serum cholesterol level QTL 67 1 4.27 1.16E-5 16.1 40126 D1Rat306 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level;increased total body fat amount Hypercholesterolemia;obesity 619669 11071303 2915 Ins1 Bw115 (interacts with);Bw116 (maps to same region);Niddm45 (interacts with) 1 246467792 290094216 5 - by peak with adj size 1 226083572 267910886 5 - by peak with adj size backcross F344/NHsdxBN/SsNHsd 10008 734526 BN/SsNHsd OLETF/Got 631836 rat Stl31 Serum triglyceride level QTL 31 1 4.64 4.87E-6 16.9 35457 D1Rat90 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia 619669 11071303 2915 Ins1 Bw115 (maps to same region);Bw116 (maps to same region);Niddm45 (interacts with) 1 266637187 290094216 5 - by peak with adj size 1 244611037 267910886 5 - by peak with adj size backcross F344/NHsdxBN/SsNHsd 10008 734526 BN/SsNHsd OLETF/Got 1 259295704 282763074 5 - by peak with adj size 1 237147813 260522016 5 - by peak with adj size 631837 rat Niddm35 Non-insulin dependent diabetes mellitus QTL 35 1 0.01 2470 Cyp2c12 35457 D1Rat90 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) decreased insulin secretion type 2 diabetes mellitus 619677;619688;1599587;2312611;1600083 10580437;11723056;16951059;17130497;19697080 Gluco51 (maps to same region);Insul12 (maps to same region) 1 266156838 289137268 1 - by flanking markers 1 222111153 267111153 4 - by one flank marker only 631294 F344.GK-(D1Arb42a-D1Rat90)/Swe 1 258709726 281795785 1 - by flanking markers 1 238699859 259647894 1 - by flanking markers 631838 rat Niddm36 Non-insulin dependent diabetes mellitus QTL 36 1 0.01 33903 D1Mit7 11148 D1Mgh25 insulin secretion trait (VT:0003564) calculated pancreatic islet insulin release measurement (CMO:0001217) decreased insulin secretion type 2 diabetes mellitus 619677;619688 10580437;11723056 1 257430719 262617194 1 - by flanking markers 1 235677683 240980142 1 - by flanking markers 631847 F344.GK-(D1Mit7-D1Mgh25)/Swe 1 205195290 250195290 4 - by one flank marker only 1 184550676 229550676 4 - by one flank marker only 631839 rat Niddm37 Non-insulin dependent diabetes mellitus QTL 37 14 3.37 33953 D14Mit1 35897 D14Rat22 2670 Gck blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619676 10218444 2670;2872;2874 Gck;Igfbp1;Igfbp3 14 12623297 106705037 1 - by flanking markers 14 12386493 102509397 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 14 12680424 106641756 1 - by flanking markers 14 11030622 95876975 1 - by flanking markers 631840 rat Niddm38 Non-insulin dependent diabetes mellitus QTL 38 19 3.86 36165 D19Rat13 34312 D19Mgh4 11389 D19Mgh2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619676;2313613;7401255 10218444;19575795;23596094 2394;3199;620475 Cpe;Npy5r;Npy2r Bw130 (maps to same region) 19 10733966 37177349 1 - by flanking markers 19 10762811 24725428 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 19 10739929 26201726 1 - by flanking markers 19 10323180 23069265 1 - by flanking markers 631841 rat Niddm39 Non-insulin dependent diabetes mellitus QTL 39 3 3.36 10502 D3Mgh10 33774 D3Mit15 11355 D3Wox8 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619676 10218444 2810;2954 Hnf4a;Kcnb1 3 106065024 174828750 1 - by flanking markers 3 93894678 161985069 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 3 99465522 168732722 1 - by flanking markers 3 94856903 159898684 1 - by flanking markers 631842 rat Inf1 Infertility severity QTL 1 8 4.1 0.001 46.0 3898 Tpm1 seminal gland mass (VT:0010524) seminal vesicle wet weight (CMO:0001603) decreased litter size;reduced male fertility;small seminal vesicle male infertility 631224 10615258 8 32174392 77174392 4 - by one flank marker only 8 26358063 71358063 4 - by one flank marker only SHR/OlaIpcvxBN-Lx/Cub 61117 631848 BN-Lx/Cub SHR/OlaIpcv 8 27841496 72841496 4 - by one flank marker only 8 22662330 67662330 4 - by one flank marker only 631843 rat Bw116 Body weight QTL 116 1 4.1 0.016 37902 D1Rat169 42550 D1Rat459 35457 D1Rat90 abdominal adipose amount (VT:1000220) abdominal fat pad weight (CMO:0000088) increased body weight;increased circulating cholesterol level hyperglycemia;type 2 diabetes mellitus 619679;619678;619669 11355573;10373320;11071303 Bw115 (maps to same region);Scl67 (maps to same region);Stl31 (maps to same region) 1 251652807 289700417 1 - by flanking markers 1 229876870 267593558 1 - by flanking markers backcross OLETFxF344 734527 OLETF.F344-(D1Rat169-D1Rat459)/Got 1 244401175 282365384 1 - by flanking markers 1 224054293 260122809 1 - by flanking markers 634305 rat Mamtr1 Mammary tumor resistance QTL 1 5 1.0E-4 69542 D5Uwm8 35306 D5Rat26 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 631852;631853 12844486;12783625 dominant 5 17423817 121495774 1 - by flanking markers 5 12880403 119333229 1 - by flanking markers 634359 WF.WKY-(D5Pas1-D5Uwm37)/Uwm 5 12651967 117554267 1 - by flanking markers 5 12789751 113558310 1 - by flanking markers 634306 rat Bp140 Blood pressure QTL 140 3 3.3 0.0013 35609 D3Rat53 38552 D3Rat80 71061 Kynu arterial blood pressure trait (VT:2000000) body weight (CMO:0000012);diastolic blood pressure (CMO:0000005);heart rate (CMO:0000002);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631322 11924719 71061 Kynu 3 18456092 41714034 1 - by flanking markers 3 16185366 32056774 2 - by one flank and peak markers intercross SHR/HosxWKY/Hos 631603 631604 WKY/Snk SHR/Snk 3 13126914 36600143 1 - by flanking markers 3 17374703 35528639 1 - by flanking markers 634307 rat Bp141 Blood pressure QTL 141 6 4.0 33977 D6Mit4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631324;1358767 10523818;15685431 Stresp10 (maps to same region) 6 47694055 92694055 5 - by peak with adj size 6 37446751 82446751 5 - by peak with adj size intercross LEW/NIcoxSHR/NIco 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 6 38106308 83106308 5 - by peak with adj size 6 35230417 80230417 5 - by peak with adj size 634308 rat Sach6 Saccharin preference QTL 6 2 4.9 31.5 38626 D2Rat171 67315 D2Arb24 36093 D2Rat26 taste sensitivity trait (VT:0001986) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) abnormal conditioned taste aversion behavior 631221 11958542 2 135770850 248088631 1 - by flanking markers 2 116874922 221284686 1 - by flanking markers intercross HXBxBXH 61098 61099 BXH/Ipcv HXB/Ipcv 2 116075644 228737869 1 - by flanking markers 2 112456140 212696837 1 - by flanking markers 634310 rat Bp142 Blood pressure QTL 142 12 4.2 33776 D12Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631324 10523818 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 634311 rat Sach7 Saccharin preference QTL 7 4 38.5 33757 D4Mit2 11468112 Hoxa2 taste sensitivity trait (VT:0001986) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) abnormal conditioned taste aversion behavior 631221 11958542 4 55539015 100539015 4 - by one flank marker only 4 55369931 100369931 4 - by one flank marker only intercross HXBxBXH 61098 61099 BXH/Ipcv HXB/Ipcv 4 55791564 82134846 1 - by flanking markers 4 57114432 81266970 1 - by flanking markers 634312 rat Bp143 Blood pressure QTL 143 1 3.0 2.0E-4 12.0 38326 D1Rat129 41036 D1Rat298 37184 D1Rat188 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631325 11984003 1 218337839 247303260 1 - by flanking markers 1 198853034 225625256 1 - by flanking markers intercross SS/HsdxSR/Hsd 634365 634366 SS/Hsd SR/Hsd 1 198446729 240017341 2 - by one flank and peak markers 1 182623426 219932796 2 - by one flank and peak markers 634313 rat Niddm43 Non-insulin dependent diabetes mellitus QTL 43 1 34244 D1Mgh10 35457 D1Rat90 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating insulin level;impaired glucose tolerance glucose intolerance 619677;619688 10580437;11723056 Niddm44 (interacts with) 1 223910550 289137268 1 - by flanking markers 1 204280278 267111153 1 - by flanking markers 631846 F344.GK-(D1Mgh10-D1Rat90)/Swe 1 217054291 281795785 1 - by flanking markers 1 199050459 259647894 1 - by flanking markers 634314 rat Niddm44 Non-insulin dependent diabetes mellitus QTL 44 1 34244 D1Mgh10 35891 D1Rat19 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating insulin level;impaired glucose tolerance glucose intolerance 619677;619688;2312611 10580437;11723056;19697080 Gluco51 (maps to same region);Niddm43 (interacts with) 1 50173266 223910550 1 - by flanking markers 1 43872827 204280278 1 - by flanking markers 634370 F344.GK-(D1Mgh10-D1Rat119)/Swe 1 49578693 217054291 1 - by flanking markers 1 49393289 199050459 1 - by flanking markers 634315 rat Niddm45 Non-insulin dependent diabetes mellitus QTL 45 1 7.16 34399 D1Mgh9 33959 D1Mit3 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) abnormal percent body fat/body weight;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619678;2312611;619669 10373320;19697080;11071303 Bw85 (maps to same region);Scl67 (interacts with);Stl31 (interacts with) 1 162692800 195235368 1 - by flanking markers 1 146971983 176854992 1 - by flanking markers backcross OLETFxBN 60985 61014 BN OLETF 1 156446783 188289244 1 - by flanking markers 1 144267916 172949660 1 - by flanking markers 634317 rat Bw117 Body weight QTL 117 3 3.58 34336 D3Mgh7 36456 D3Rat41 abdominal fat pad mass (VT:1000711) abdominal fat pad weight to body weight ratio (CMO:0000095) increased total body fat amount obesity 619678;2313613;2298688 10373320;19575795;18612083 Bw82 (maps to same region) 3 45609749 61363738 1 - by flanking markers 3 36556706 50635971 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 3 40523593 54745780 1 - by flanking markers 3 39454637 53296578 1 - by flanking markers 634318 rat Bw118 Body weight QTL 118 6 3.55 33977 D6Mit4 33828 D6Mit9 abdominal fat pad mass (VT:1000711) abdominal fat pad weight (CMO:0000088) decreased body weight;decreased circulating glucose level;decreased total body fat amount obesity 619678 10373320 6 46021394 70193933 1 - by flanking markers 6 34039461 59946628 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 6 36260288 60606186 1 - by flanking markers 6 33309549 57730294 1 - by flanking markers 634319 rat Bw119 Body weight QTL 119 7 5.44 36715 D7Rat30 36715 D7Rat30 36715 D7Rat30 abdominal fat pad mass (VT:1000711) abdominal fat pad weight to body weight ratio (CMO:0000095) decreased total body fat amount;impaired glucose tolerance obesity;type 2 diabetes mellitus 619678 10373320 7 34212196 34212335 1 - by flanking markers 7 30339292 30339432 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 7 34147033 34147172 1 - by flanking markers 7 27828949 27829089 1 - by flanking markers 634320 rat Niddm49 Non-insulin dependent diabetes mellitus QTL 49 10 4.41 11169 D10Mgh21 33941 D10Mit11 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) decreased circulating glucose level type 2 diabetes mellitus 619678 10373320 10 91455889 112200500 4 - by one flank marker only 10 92782172 101848683 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 10 91689348 112626471 4 - by one flank marker only 10 88539139 107211142 4 - by one flank marker only 634321 rat Hc1 Hypercalciuria QTL 1 1 2.91 7.0 39006 D1Rat193 38078 D1Rat142 37902 D1Rat169 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 1 201022827 268717248 1 - by flanking markers 1 183163129 248833756 1 - by flanking markers intercross SD/GHSxWKY 61103 634372 WKY GHS 1 193968438 261264776 1 - by flanking markers 1 178810256 240830002 1 - by flanking markers 634322 rat Bw12 Body weight QTL 12 7 0.0 37808 D7Rat86 38402 D7Rat102 38402 D7Rat102 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619682 11414764 7 96743589 141743589 5 - by peak with adj size 7 88132195 115934193 1 - by flanking markers intercross BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc 6 10173862 55173862 4 - by one flank marker only 7 83153392 128153392 4 - by one flank marker only 634323 rat Hc2 Hypercalciuria QTL 2 4 2.15 39704 D4Rat222 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 4 1 42064565 5 - by peak with adj size 4 1 41544239 5 - by peak with adj size intercross SD/GHSxWKY 61103 634372 WKY GHS 4 1 42118977 5 - by peak with adj size 4 210796 45210796 5 - by peak with adj size 634325 rat Bw13 Body weight QTL 13 X 0.0 35030 DXRat2 36111 DXRat8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight;increased circulating insulin level;pancreas inflammation hyperinsulinism;pancreatitis 619682 11414764 X 2456432 21859240 1 - by flanking markers X 1 41387080 4 - by one flank marker only intercross BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc X 1662453 21592783 1 - by flanking markers X 1447972 20991088 1 - by flanking markers 634326 rat Hc3 Hypercalciuria QTL 3 7 2.1 40164 D7Rat164 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 7 50418802 95418802 5 - by peak with adj size 7 47007003 92007003 5 - by peak with adj size intercross SD/GHSxWKY 61103 634372 WKY GHS 7 50252103 95252103 5 - by peak with adj size 7 42787314 87787314 5 - by peak with adj size 634327 rat Hc4 Hypercalciuria QTL 4 10 2.4 35769 D10Rat47 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 10 1 38488522 5 - by peak with adj size 10 1 38576664 5 - by peak with adj size intercross SD/GHSxWKY 61103 634372 WKY GHS 10 1 38594330 5 - by peak with adj size 10 1 38328221 5 - by peak with adj size 634328 rat Hc5 Hypercalciuria QTL 5 14 2.3 11086 D14Mgh1 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 14 64239904 109239904 5 - by peak with adj size 14 63969145 108969145 5 - by peak with adj size 61103 634372 WKY GHS 14 63548095 108548095 5 - by peak with adj size 14 58184885 103184885 5 - by peak with adj size 634329 rat Pia15 Pristane induced arthritis QTL 15 10 3.1 36319 D10Rat26 36522 D10Rat44 34318 D10Mgh10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198;2296064 12817024;18606636;16804090;18540828;18453595 dominant Eau7 (maps to same region) 10 24738710 47171288 2 - by one flank and peak markers 10 24731630 47777990 2 - by one flank and peak markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 10 24884084 47487910 2 - by one flank and peak markers 10 1 24158324 4 - by one flank marker only 634330 rat Pia16 Pristane induced arthritis QTL 16 6 3.9 34072 D6Mgh7 34108 D6Mgh10 35102 D6Rat16 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198 12817024;18606636;16804090;18540828 dominant 6 57131392 117277618 1 - by flanking markers 6 47039212 108621490 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 6 48432758 108268790 1 - by flanking markers 6 45790088 104200226 1 - by flanking markers 634331 rat Pia17 Pristane induced arthritis QTL 17 7 4.7 11165 D7Mit9 37144 D7Rat74 33670 D7Mit2 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198 12817024;18606636;16804090;18540828 dominant 7 81663683 143501887 2 - by one flank and peak markers 7 78497123 137838800 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 7 81645773 140745067 1 - by flanking markers 7 73829340 130221005 1 - by flanking markers 634332 rat Pia18 Pristane induced arthritis QTL 18 8 4.0 35905 D8Rat21 35248 D8Rat26 34068 D8Mgh11 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198 12817024;18606636;16804090;18540828 dominant 8 81033305 89073299 1 - by flanking markers 8 79347688 87122814 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 8 81414058 89542815 1 - by flanking markers 8 75311938 82925521 1 - by flanking markers 634333 rat Pia19 Pristane induced arthritis QTL 19 18 3.4 35282 D18Rat5 33715 D18Mit6 33715 D18Mit6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2307198;2300074;1582387 12817024;18540828;18606636;16804090 dominant 18 76260634 82427750 1 - by flanking markers 18 77452390 82920522 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 18 77151301 83366399 1 - by flanking markers 18 73997140 79532029 1 - by flanking markers 634334 rat Xhs3 X-ray hypersensitivity QTL 3 4 10.0 42306 D4Rat266 35262 D4Rat79 36043 D4Rat49 intestine integrity trait (VT:0010554) post-insult time to onset of moribundity (CMO:0001896) increased cellular sensitivity to X-ray irradiation Experimental Radiation Injuries 631318 11381618 recessive 4 150446360 194116548 1 - by flanking markers 4 84355208 131969855 1 - by flanking markers intercross LEA/NcuxBN/Sea 634376 634377 LEA/Ncu BN/Sea 4 85794049 129615056 1 - by flanking markers 4 84728680 129854654 1 - by flanking markers 634335 rat Anxrr16 Anxiety related response QTL 16 4 7.22 50.4 34338 D4Mgh11 35286 D4Rat37 34106 D4Mgh6 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 631324;1598975;1598390;6218999 10523818;17052845;16923148;21516450 3811 Tacr1 dominant 4 159682169 230565073 1 - by flanking markers 4 93498821 171204377 1 - by flanking markers intercross LEW/NIcoxSHR/NIco 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 4 94893247 168046938 1 - by flanking markers 11528588 SHR.LEW-(D4Rat76-D4Mgh11)/Anra 4 93308457 167139447 1 - by flanking markers 634336 rat Anxrr17 Anxiety related response QTL 17 7 3.66 39648 D7Rat127 34039 D3Mit11 34164 D7Mgh11 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased anxiety-related response anxiety disorder 631324;1598975;1598390 10523818;17052845;16923148 additive 7 2893487 124826707 1 - by flanking markers 7 1786555 121975577 1 - by flanking markers intercross LEW/NIcoxSHR/NIco 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 7 2920071 124838025 1 - by flanking markers 7 924703 115097879 1 - by flanking markers 634338 rat Hcar4 Hepatocarcinoma resistance QTL 4 1 4.6 34021 D1Mit28 43424 D1Wox10 34244 D1Mgh10 liver integrity trait (VT:0010547) liver tumorous lesion number to liver area ratio (CMO:0001210) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 2315;2758;2775;2827;2829;2870;2916 Cd81;Gstp1;H19;Hras;Plaat3;Igf2;Ins2 recessive 1 217888119 244066407 1 - by flanking markers 1 198396580 220639653 1 - by flanking markers intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 1 210960636 236763528 1 - by flanking markers 1 193422268 214537671 1 - by flanking markers 634339 rat Niddm50 Non-insulin dependent diabetes mellitus QTL 50 11 3.32 34725 D11Mgh3 34150 D11Mgh5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) abnormal percent body fat/body weight;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619678;61072 10373320;9585427 11 47637447 72739687 1 - by flanking markers 11 43157054 68234781 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 11 44444347 69649708 1 - by flanking markers 11 66422148 86241447 4 - by one flank marker only 634340 rat Hcar5 Hepatocarcinoma resistance QTL 5 1 8.0 43424 D1Wox10 41392 D1Rat302 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 2456;2469 Cyp17a1;Cyp2c11 recessive 1 244066294 254305341 1 - by flanking markers 1 220639539 232579992 1 - by flanking markers intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 1 236763415 247065599 1 - by flanking markers 1 214537555 226660468 1 - by flanking markers 634341 rat Bw121 Body weight QTL 121 11 3.56 34150 D11Mgh5 33899 D11Mit4 abdominal fat pad mass (VT:1000711) abdominal fat pad weight (CMO:0000088) increased body weight;increased total body fat amount obesity 619678 10373320 11 25682771 47637212 1 - by flanking markers 11 22214205 43156819 1 - by flanking markers backcross OLETFxBN 60985 61014 BN OLETF 11 22043149 44444112 1 - by flanking markers 11 1 21836709 4 - by one flank marker only 634342 rat Cia24 Collagen induced arthritis QTL 24 4 4.5 7.6 33995 D4Mit19 10752 D4Wox12 11163 D4Arb2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2307198;2300074;1582387;619594 10857786;18540828;18606636;16804090;11486281 2306;61318;61319;621237 Cd4;Cd69;Tnfrsf7;Tnfrsf1a additive 4 208670980 240723450 1 - by flanking markers 4 149304432 179854843 1 - by flanking markers intercross DA/BklxBN/SsN 61114 61115 DA/Bkl BN/SsN 4 145373934 176509907 1 - by flanking markers 4 146565735 175236377 1 - by flanking markers 634343 rat Hcar6 Hepatocarcinoma resistance QTL 6 1 10674 D1Mgh12 liver integrity trait (VT:0010547) area of individual liver tumorous lesion (CMO:0001071) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609 10850431 recessive 1 248216971 290094216 5 - by peak with adj size 1 224822211 267910886 5 - by peak with adj size intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 634344 rat Hcar7 Hepatocarcinoma resistance QTL 7 4 7.8 35811 D4Rat23 35286 D4Rat37 35286 D4Rat37 liver integrity trait (VT:0010547) liver tumorous lesion area to total liver area ratio (CMO:0001075);liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 2688 Ghrhr semidominant 4 58518376 159682169 1 - by flanking markers 4 58550170 93498821 1 - by flanking markers intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 4 71476518 116476518 5 - by peak with adj size 4 70808386 115808386 5 - by peak with adj size 634346 rat Insul4 Insulin level QTL 4 X 0.0 12.0 39724 DXRat103 60694 DXGot62 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level;increased heart weight;pancreas inflammation hyperinsulinism;pancreatitis 619682 11414764 additive X 134700617 154597545 4 - by one flank marker only X 134157190 160699376 4 - by one flank marker only intercross BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc X 134627816 159970021 4 - by one flank marker only X 126975089 152453651 4 - by one flank marker only 634347 rat Hcar8 Hepatocarcinoma resistance QTL 8 4 5.8 36508 D4Rat48 liver integrity trait (VT:0010547) liver tumorous lesion area to total liver area ratio (CMO:0001075) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 3849 Tgfa semidominant 4 187067577 232067577 4 - by one flank marker only intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 4 123478354 168478354 4 - by one flank marker only 4 123143783 168143783 4 - by one flank marker only 634348 rat Bp138 Blood pressure QTL 138 1 37428 D1Rat200 2254 Calca 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631321 12358148 2156;2254;3214;621323 Arrb1;Calca;Ntrk3;Phox2a 1 134116233 191162954 1 - by flanking markers 1 126938969 172691061 1 - by flanking markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 1 133076978 184188922 1 - by flanking markers 1 125611501 168883176 1 - by flanking markers 634349 rat Bp139 Blood pressure QTL 139 5 0.001 10454 D5Wox12 43937 D5Wox20 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631851 12790759 5 137990322 177180328 4 - by one flank marker only 5 135877124 173096209 4 - by one flank marker only 634382 SHR.BN-(D5Wox12-D5Wox20)/Ipcv 5 134197905 173707219 4 - by one flank marker only 5 128924607 166875058 4 - by one flank marker only 634350 rat Apr4 Acute phase response QTL 4 12 6.0 35889 D12Rat10 orosomucoid 1 amount (VT:0010541) plasma orosomucoid 1 level (CMO:0001467) abnormal acute phase protein level rheumatoid arthritis 629561 11817600 recessive 12 6200431 51200431 5 - by peak with adj size 12 2248421 46782294 5 - by peak with adj size intercross E3xDA 60997 61013 DA E3 12 4210051 49210051 5 - by peak with adj size 12 1172005 46172005 5 - by peak with adj size 634351 rat Apr5 Acute phase response QTL 5 12 6.7 11449 D12Wox14 blood interleukin-6 amount (VT:0008595) plasma interleukin-6 level (CMO:0001927) abnormal circulating interleukin-6 level rheumatoid arthritis 629561 11817600 recessive 12 4514063 49514063 5 - by peak with adj size 12 568621 45568621 5 - by peak with adj size intercross E3xDA 60997 61013 DA E3 12 2513442 47513442 5 - by peak with adj size 12 1 44503507 5 - by peak with adj size 634352 rat Apr6 Acute phase response QTL 6 14 3.7 10622 D14Mgh3 blood interleukin-6 amount (VT:0008595) plasma interleukin-6 level (CMO:0001927) abnormal circulating interleukin-6 level rheumatoid arthritis 629561 11817600 recessive 14 1 42672729 5 - by peak with adj size 14 1 42665455 5 - by peak with adj size intercross E3xDA 60997 61013 DA E3 14 1 42766285 5 - by peak with adj size 14 1 41131407 5 - by peak with adj size 634353 rat Rends2 Renal damage susceptibility QTL 2 1 0.05 36303 D1Rat6 37962 D1Rat201 38568 D1Rat238 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) abnormal kidney vasculature morphology end stage renal disease 631854 12874092 1 21827911 58931238 1 - by flanking markers 1 19793567 54719627 1 - by flanking markers intercross SHRSPxSHR 61000 61010 SHR SHRSP 1 20341560 58000154 1 - by flanking markers 1 19333571 56983283 1 - by flanking markers 634354 rat Rends3 Renal damage susceptibility QTL 3 10 0.05 35563 D10Rat21 34939 D10Rat55 2875 Igfbp4 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) abnormal kidney vasculature morphology end stage renal disease 631854 12874092 10 82495432 87933580 1 - by flanking markers 10 83527877 89167279 1 - by flanking markers SHRSPxSHR 61000 61010 SHR SHRSP 10 82675233 88141097 1 - by flanking markers 10 79813789 85160854 1 - by flanking markers 634355 rat Rends4 Renal damage susceptibility QTL 4 16 0.05 33848 D16Mit2 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) abnormal kidney vasculature morphology end stage renal disease 631854 12874092 16 1 27496499 5 - by peak with adj size 16 1 26804456 5 - by peak with adj size intercross SHRSPxSHR 61000 61010 SHR SHRSP 16 1 27556253 5 - by peak with adj size 16 1 26727669 5 - by peak with adj size 724513 rat Uae14 Urinary albumin excretion QTL 14 6 6.5 36191 D6Rat6 37280 D6Rat104 36990 D6Rat12 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 6 98478049 132488388 1 - by flanking markers 6 88723578 123455031 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 6 88996335 139410483 2 - by one flank and peak markers 6 85311061 133478515 2 - by one flank and peak markers 724514 rat Uae15 Urinary albumin excretion QTL 15 8 2.9 40746 D8Rat162 35987 D8Rat30 36117 D8Rat46 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 8 32227585 80296943 1 - by flanking markers 8 30878636 74178909 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 8 32201981 75971421 1 - by flanking markers 8 29502665 70386295 1 - by flanking markers 724515 rat Uae16 Urinary albumin excretion QTL 16 9 8.0 8.0 36027 D9Rat3 34013 D9Mit3 35691 D9Rat5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 9 63077544 107462655 1 - by flanking markers 9 55476135 99799760 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 9 63270073 107878387 1 - by flanking markers 9 58163035 100929646 1 - by flanking markers 724516 rat Uae17 Urinary albumin excretion QTL 17 10 3.6 41534 D10Rat143 37460 D10Rat93 35108 D10Rat30 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 10 80788180 87993909 1 - by flanking markers 10 81887390 89227496 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 10 80946110 88200662 1 - by flanking markers 10 78210622 85220348 1 - by flanking markers 724517 rat Uae18 Urinary albumin excretion QTL 18 11 3.7 35565 D11Rat20 36065 D11Rat6 33792 D11Mit2 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 11 19976405 49765656 1 - by flanking markers 11 16670176 45232986 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 11 16321973 46583360 1 - by flanking markers 11 16472047 44285911 1 - by flanking markers 724518 rat Uae19 Urinary albumin excretion QTL 19 19 5.5 33618 D19Mit7 37042 D19Rat19 35881 D19Rat11 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 19 8062244 58132164 1 - by flanking markers 19 7813671 45090802 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 19 8072545 47318201 1 - by flanking markers 19 7457249 42983518 1 - by flanking markers 724519 rat Bp144 Blood pressure QTL 144 20 0.001 61303 D20Utr1 3876 Tnf 61303 D20Utr1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 619638 8938440 20 1 6938847 4 - by one flank marker only 20 1 3663618 4 - by one flank marker only intercross 61098 BXH/Ipcv 20 1 5192000 4 - by one flank marker only 20 1 3624629 4 - by one flank marker only 724520 rat Bp145 Blood pressure QTL 145 1 2.1 0.0024 38782 D1Rat136 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 634618 12397040 1 22407702 67407702 5 - by peak with adj size 1 15147212 60147212 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 1 21079305 66079305 5 - by peak with adj size 1 20784828 65784828 5 - by peak with adj size 724521 rat Uae1 Urinary albumin excretion QTL 1 1 3.8 1.0E-4 36765 D1Rat27 39314 D1Rat216 36023 D1Rat38 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 1 95301716 205161264 1 - by flanking markers 1 90282040 185923619 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 1 94201400 184846632 2 - by one flank and peak markers 1 90508614 173018436 2 - by one flank and peak markers 724522 rat Bp146 Blood pressure QTL 146 4 2.2 0.0021 35325 D4Rat41 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 634618 12397040 4 140044845 185044845 5 - by peak with adj size 4 74123346 119123346 5 - by peak with adj size 724569 724570 MWF/FubRkb LEW/Rkb 4 75258970 120258970 5 - by peak with adj size 4 73630210 118630210 5 - by peak with adj size 724523 rat Tsu1 Thymus enlargement suppressive QTL 1 3 3.84 33668 D3Mit13 3632 Scn2a 2279 Cat thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) small thymus Thymus Hyperplasia 634729 9234381 3 58456658 129091156 1 - by flanking markers 3 47722800 115996144 1 - by flanking markers backcross BUF/MnaxMITE/Mna 61118 724571 BUF/Mna MITE/Mna 3 51822008 120917851 1 - by flanking markers 3 50437504 115638231 1 - by flanking markers 724524 rat Uae2 Urinary albumin excretion QTL 2 6 2.7 5.0E-4 36990 D6Rat12 34306 D6Mgh5 38246 D6Rat71 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 6 86432188 123469988 1 - by flanking markers 6 76380261 114031923 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 6 76902247 114203334 1 - by flanking markers 6 73463459 109394713 1 - by flanking markers 724525 rat Bp147 Blood pressure QTL 147 5 4.3 1.0E-4 35825 D5Rat41 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 634618 12397040 5 136316651 177180328 5 - by peak with adj size 5 132950669 173096209 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 5 132551937 173707219 5 - by peak with adj size 5 126424772 166875058 5 - by peak with adj size 724526 rat Uae3 Urinary albumin excretion QTL 3 12 4.9 1.0E-4 39744 D12Rat59 38052 D12Rat37 36538 D12Rat7 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 12 7519792 14407498 1 - by flanking markers 12 155313 10701201 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 12 5406094 12355490 1 - by flanking markers 12 3906969 10373166 1 - by flanking markers 724527 rat Bp148 Blood pressure QTL 148 10 1.0E-4 631289 D10M11Mit119 36203 D10Rat27 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 704345 12939233 10 29127968 74127968 4 - by one flank marker only 10 32092169 77092169 4 - by one flank marker only 12902614 SS.LEW-(D10M11Mit119-D10Rat27)/Ayd 10 30983805 75983805 4 - by one flank marker only 10 28453136 73453136 4 - by one flank marker only 724528 rat Uae4 Urinary albumin excretion QTL 4 17 4.9 1.0E-4 36011 D17Rat17 35473 D17Rat58 40276 D17Rat133 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 17 39651255 75089871 1 - by flanking markers 17 42344830 81039660 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 17 37790306 73413148 1 - by flanking markers 17 35837085 69599340 1 - by flanking markers 724529 rat Cm16 Cardiac mass QTL 16 1 2.7 38420 D1Rat189 37168 D1Rat158 36007 D1Rat36 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight;increased systemic arterial blood pressure heart disease;hypertension 634617 12707388 1 91941720 167535765 1 - by flanking markers 1 87465281 153578547 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 1 90804143 161321256 1 - by flanking markers 1 87580395 150700247 1 - by flanking markers 724530 rat Bp149 Blood pressure QTL 149 10 1.0E-4 34896 D10Rat17 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 704345 12939233 10 93641751 112200500 4 - by one flank marker only 10 95066219 99588446 1 - by flanking markers 724575 SS.LEW-(D10Rat17-D10Mgh1)/Ayd 10 93886117 112626471 4 - by one flank marker only 10 90627439 107211142 4 - by one flank marker only 724531 rat Uae5 Urinary albumin excretion QTL 5 1 4.0 37168 D1Rat158 36703 D1Rat86 66610 D1Mco35 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 1 167535661 281205280 1 - by flanking markers 1 153578442 259173490 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 1 161321152 273792054 1 - by flanking markers 1 150700142 252085212 1 - by flanking markers 724532 rat Cm17 Cardiac mass QTL 17 3 2.0 41442 D3Rat160 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 3 107558308 152558308 5 - by peak with adj size 3 96192217 141192217 5 - by peak with adj size intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 3 101058963 146058963 5 - by peak with adj size 3 95735366 140735366 5 - by peak with adj size 724533 rat Rf51 Renal function QTL 51 1 5.3 2.0E-4 34194 D1Mgh14 33945 D1Mit18 33903 D1Mit7 kidney plasma flow trait (VT:0005524) renal plasma flow (CMO:0001914) decreased renal glomerular filtration rate;decreased renal plasma flow rate;increased renal vascular resistance kidney disease 619628 10545438 codominant 1 246119106 285604773 1 - by flanking markers 1 224426393 263698966 1 - by flanking markers intercross SHRxWKY 61000 61103 SHR WKY 1 238830534 278228767 1 - by flanking markers 1 218753816 256448513 1 - by flanking markers 724534 rat Uae6 Urinary albumin excretion QTL 6 2 10.0 66661 D2Mco18 35915 D2Rat61 36773 D2Rat50 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;glomerulosclerosis;increased urine protein level Albuminuria;focal segmental glomerulosclerosis;proteinuria 634617 12707388 2 88595515 100298396 1 - by flanking markers 2 79796833 227150249 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 2 68866454 80631953 1 - by flanking markers 2 78665619 249053267 2 - by one flank and peak markers 724535 rat Cm18 Cardiac mass QTL 18 4 2.6 40642 D4Rat195 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 4 182393351 227393351 5 - by peak with adj size 4 121375269 166375269 5 - by peak with adj size intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 4 117926139 162926139 5 - by peak with adj size 4 118856416 163856416 5 - by peak with adj size 724536 rat Uae7 Urinary albumin excretion QTL 7 6 3.5 11241 D6Mit3 10361 D6Wox13 66623 D6Uia5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 6 85163175 144273990 1 - by flanking markers 6 75049527 136452267 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 6 75623277 136143011 1 - by flanking markers 6 72202632 130729475 1 - by flanking markers 724537 rat Niddm52 Non-insulin dependent diabetes mellitus QTL 52 7 0.02 33648 D7Mit5 10939 D7Mit27 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 7 88393619 103159589 1 - by flanking markers 7 85089895 98955278 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 7 88365265 102588450 1 - by flanking markers 7 80221299 93595843 1 - by flanking markers 724538 rat Kidm1 Kidney mass QTL 1 1 3.2 62481 D1Uia5 36703 D1Rat86 36703 D1Rat86 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) decreased circulating free fatty acids level kidney disease 634617 12707388 1 240777376 281205280 1 - by flanking markers 1 219804771 259173490 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 1 233663100 273792054 1 - by flanking markers 1 213707201 252085212 1 - by flanking markers 724539 rat Cm19 Cardiac mass QTL 19 8 2.6 41310 D8Rat130 35435 D8Rat3 37892 D8Rat90 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 8 100888495 129152962 1 - by flanking markers 8 98986085 126316942 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 8 107769005 129956433 2 - by one flank and peak markers 8 100149864 120994388 2 - by one flank and peak markers 724540 rat Uae8 Urinary albumin excretion QTL 8 8 5.0 33559 D8Mit5 41310 D8Rat130 40746 D8Rat162 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 8 33603024 100888674 1 - by flanking markers 8 32203394 98986263 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 8 30845450 33558764 2 - by one flank and peak markers 8 28157323 30848259 2 - by one flank and peak markers 724541 rat Niddm53 Non-insulin dependent diabetes mellitus QTL 53 14 0.001 36536 D14Rat1 37030 D14Rat3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 14 4830815 10676655 1 - by flanking markers 14 4895894 10340377 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 4833233 10729268 1 - by flanking markers 14 3813074 9088978 1 - by flanking markers 724542 rat Kidm2 Kidney mass QTL 2 18 2.6 38862 D18Rat69 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) decreased circulating free fatty acids level kidney disease 634617 12707388 18 62060256 87229863 5 - by peak with adj size 18 62739615 87265094 5 - by peak with adj size intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 18 63009812 88201929 5 - by peak with adj size 18 59172115 83828827 5 - by peak with adj size 724543 rat Cm20 Cardiac mass QTL 20 9 3.9 35871 D9Rat36 35819 D9Rat26 37416 D9Rat70 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 9 18398986 44725204 1 - by flanking markers 9 12625041 37313370 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 9 19520489 45029794 1 - by flanking markers 9 16961398 40594091 1 - by flanking markers 724544 rat Uae9 Urinary albumin excretion QTL 9 9 4.5 37416 D9Rat70 66431 D9Mco6 61287 D9Uia6 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria Albuminuria 634617 12707388 9 27914255 121549591 2 - by one flank and peak markers 9 21667066 105580061 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 9 29075079 122095297 2 - by one flank and peak markers 9 25268044 114175309 2 - by one flank and peak markers 724545 rat Niddm54 Non-insulin dependent diabetes mellitus QTL 54 15 0.02 35362 D15Rat19 35230 D15Rat22 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 15 61238603 84802960 1 - by flanking markers 15 56346569 80370658 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 15 57528970 81263988 1 - by flanking markers 15 50794494 73699215 1 - by flanking markers 724546 rat Kidm3 Kidney mass QTL 3 19 3.1 39018 D19Rat29 66451 D19Uia1 66451 D19Uia1 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) decreased circulating free fatty acids level kidney disease 634617 12707388 19 43887287 72914587 4 - by one flank marker only 19 31224173 59218465 4 - by one flank marker only intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 19 32994392 62275575 4 - by one flank marker only 19 29322490 57337602 4 - by one flank marker only 724547 rat Cm21 Cardiac mass QTL 21 9 2.7 61287 D9Uia6 66431 D9Mco6 38270 D9Rat97 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 9 83451810 111224462 2 - by one flank and peak markers 9 77170797 105580061 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 9 83686153 111609081 2 - by one flank and peak markers 9 79271511 102910209 2 - by one flank and peak markers 724548 rat Niddm55 Non-insulin dependent diabetes mellitus QTL 55 15 0.02 35230 D15Rat22 36663 D15Rat21 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 15 79317715 84802815 1 - by flanking markers 15 74779895 80370512 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 15 75761216 81263843 1 - by flanking markers 15 68327360 73699069 1 - by flanking markers 724549 rat Niddm56 Non-insulin dependent diabetes mellitus QTL 56 17 0.03 33882 D17Mit2 34369 D17Mgh4 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 17 35195242 80195242 4 - by one flank marker only 17 38353858 83353858 4 - by one flank marker only intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 17 33303627 78303627 4 - by one flank marker only 17 31990784 76990784 4 - by one flank marker only 724550 rat Thym3 Thymus enlargement QTL 3 1 7.82 0.001 33571 D1Mit6 10952 D1Wox21 38210 D1Rat197 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) enlarged thymus Thymus Hyperplasia 70859 10792781 Thym1 (interacts with) 1 160649707 205649707 4 - by one flank marker only 1 141471946 186471946 4 - by one flank marker only backcross BUF/MnaxMITE/Mna 61118 724571 BUF/Mna MITE/Mna 1 153655976 198655976 4 - by one flank marker only 1 136829932 181829932 4 - by one flank marker only 724551 rat Glom1 Glomerulus QTL 1 X 2.8 4.0E-4 39966 DXRat96 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 634618 12397040 X 82820145 127820145 5 - by peak with adj size X 99569771 144569771 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb X 82930791 127930791 5 - by peak with adj size X 75294106 120294106 5 - by peak with adj size 724552 rat Glom2 Glomerulus QTL 2 1 3.3 1.0E-4 37506 D1Rat151 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) abnormal renal glomerulus morphology Albuminuria;proteinuria 634618 12397040 1 250702278 290094216 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 1 243272341 282763074 5 - by peak with adj size 1 222363780 260522016 5 - by peak with adj size 724553 rat Glom3 Glomerulus QTL 3 13 2.9 4.0E-4 39348 D13Rat62 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) abnormal renal glomerulus morphology Albuminuria;proteinuria 634618 12397040 13 46101962 91101962 5 - by peak with adj size 13 38179982 83179982 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 724554 rat Iddm17 Insulin dependent diabetes mellitus QTL 17 11 0.001 10847 D11Mit8 34130 D11Mgh6 10911 D11Wox3 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) pancreas inflammation Chronic Pancreatitis;type 1 diabetes mellitus 634732 9329965 11 22660494 93518069 2 - by one flank and peak markers 11 19445919 87759784 2 - by one flank and peak markers backcross LETOxPKDP 68149 724576 TM KDP/Tky 11 19016272 90463843 2 - by one flank and peak markers 11 18976208 86241447 2 - by one flank and peak markers 724555 rat Bp150 Blood pressure QTL 150 10 1.0E-4 36203 D10Rat27 37460 D10Rat93 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 704345 12939233 10 74127825 80788180 1 - by flanking markers 10 77091834 81887390 1 - by flanking markers 724577 SS.LEW-(D10Rat27-Igfbp4)/Ayd 10 75983662 80946110 1 - by flanking markers 10 73452992 78210622 1 - by flanking markers 724556 rat Pur2 Proteinuria QTL 2 10 5.5 62429 D10Uia2 34896 D10Rat17 66468 D10Mco57 urine protein amount (VT:0005160) urine protein level (CMO:0000591) increased urine protein level proteinuria 634617 12707388 10 22763210 93641934 1 - by flanking markers 10 22915259 95066632 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 10 22901497 93886300 1 - by flanking markers 10 22427500 90627625 1 - by flanking markers 724557 rat Plsm1 Polydactyly-luxate syndrome (PLS) morphotypes QTL 1 4 3.0E-4 2901 Il6 forelimb integrity trait (VT:0010562) front foot phalanges count (CMO:0001947) polydactyly polydactyly 632346 8997636 2901 Il6 4 1 25597824 5 - by peak with adj size 4 1 22959087 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 4 1 25545519 5 - by peak with adj size 4 1 27716890 5 - by peak with adj size 724558 rat Plsm2 Polydactyly-luxate syndrome (PLS) morphotypes QTL 2 4 3.0E-4 2004 A2m hindlimb integrity trait (VT:0010563) hind foot phalanges count (CMO:0001949) polydactyly polydactyly 632346 8997636 2004 A2m 4 198918089 243918089 5 - by peak with adj size 4 135628567 180628567 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 4 131834282 176834282 5 - by peak with adj size 4 132422778 177422778 5 - by peak with adj size 724559 rat Pancm1 Pancreatic morphology QTL 1 1 7.1 8.0 43424 D1Wox10 3750 Spn 11060 D1Wox23 islet of Langerhans morphology trait (VT:0005215) pancreatic islet damage composite score (CMO:0001156) abnormal pancreatic islet morphology type 2 diabetes mellitus 61083 9169130 3750 Spn 1 205576290 244066294 1 - by flanking markers 1 186391887 220639539 1 - by flanking markers Intercross 13MxWKY 61103 61112 WKY 13M 1 198585664 236763415 1 - by flanking markers 1 181759564 214537555 1 - by flanking markers 724560 rat Plsm3 Polydactyly-luxate syndrome (PLS) morphotypes QTL 3 7 3.0E-4 33721 D7Mit17 tibia length (VT:0004357) tibia length (CMO:0000450) short tibia Congenital Limb Deformities 632346 8997636 7 1 37162479 5 - by peak with adj size 7 1 35575619 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 7 1 37009673 5 - by peak with adj size 7 1 34000259 5 - by peak with adj size 724561 rat Plsm4 Polydactyly-luxate syndrome (PLS) morphotypes QTL 4 11 3.0E-4 3761 Sst forelimb integrity trait (VT:0010562) front foot phalanges count (CMO:0001947) polydactyly polydactyly 632346 8997636 11 57874854 93518069 5 - by peak with adj size 11 56625623 87759784 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 11 57858810 90463843 5 - by peak with adj size 11 54457534 86241447 5 - by peak with adj size 724562 rat Rends1 Renal damage susceptibility QTL 1 1 0.05 60787 D1Wox6 43424 D1Wox10 kidney glomerulus integrity trait (VT:0010546) index of glomerular damage (CMO:0001135) abnormal kidney vasculature morphology;abnormal renal glomerulus morphology;increased urine protein level end stage renal disease;proteinuria 632218 10454439 1 138777913 244066407 1 - by flanking markers 1 131956599 220639653 1 - by flanking markers 61100 628908 SHR/Ola SHR.BN-(D1Mit3-Igf2)/Ipcv 1 137787261 236763528 1 - by flanking markers 737972 BN/Crl 1 169537671 214537671 4 - by one flank marker only 724563 rat Uae10 Urinary albumin excretion QTL 10 11 6.0 36906 D11Rat17 37512 D11Rat50 39698 D11Rat67 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 11 31929422 90087579 1 - by flanking markers 11 28213024 84841212 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 11 28314665 86994795 1 - by flanking markers 11 27672410 82846715 1 - by flanking markers 724564 rat Uae11 Urinary albumin excretion QTL 11 13 5.7 11231 D13Wox5 37240 D13Rat63 38990 D13Rat58 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria Albuminuria 634617 12707388 13 55560677 87877411 1 - by flanking markers 13 46269934 80482429 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 13 64501351 82995671 2 - by one flank and peak markers 13 59492522 77046890 2 - by one flank and peak markers 724565 rat Tcas5 Tongue tumor susceptibility QTL 5 19 10.04 33581 D19Mit1 10418 D19Mit6 11471 D19Mit9 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 2503;2944 Nqo1;Junb semidominant 19 16155908 54715514 2 - by one flank and peak markers 19 11456899 41612881 2 - by one flank and peak markers intercross DAxWF 60997 61007 DA WF 19 5007571 43907843 2 - by one flank and peak markers 19 9977753 39654489 2 - by one flank and peak markers 724566 rat Uae12 Urinary albumin excretion QTL 12 19 5.0 39128 D19Rat34 66451 D19Uia1 39018 D19Rat29 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria Albuminuria 634617 12707388 19 2413720 72914587 2 - by one flank and peak markers 19 2264957 59218465 2 - by one flank and peak markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 19 2432963 62275575 2 - by one flank and peak markers 19 2187927 56457239 2 - by one flank and peak markers 724567 rat Tcas6 Tongue tumor susceptibility QTL 6 1 6.85 34037 D1Mit1 33959 D1Mit3 39428 D1Rat320 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 2466 Cyp2b1 semidominant 1 91268282 162692800 2 - by one flank and peak markers 1 92101613 146971983 2 - by one flank and peak markers intercross DAxWF 60997 61007 DA WF 1 95304961 156446783 2 - by one flank and peak markers 1 92948896 144267916 2 - by one flank and peak markers 724568 rat Uae13 Urinary albumin excretion QTL 13 2 4.4 35857 D2Rat36 34884 D2Rat57 39374 D2Rat126 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633;634617 12799471;12707388 2 187719129 243539067 2 - by one flank and peak markers 2 161170272 218568266 2 - by one flank and peak markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 2 149114878 225501939 1 - by flanking markers 2 143157029 210020885 1 - by flanking markers 731164 rat Uae25 Urinary albumin excretion QTL 25 9 3.5 1.0E-4 36984 D9Rat29 36027 D9Rat3 36556 D9Rat10 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 9 28304251 107462796 1 - by flanking markers 9 22066101 99799902 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 9 29466970 107878528 1 - by flanking markers 9 25661188 100929786 1 - by flanking markers 731165 rat Uae21 Urinary albumin excretion QTL 21 4 2.4 1.0E-4 38458 D4Rat95 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 4 170855470 215855470 5 - by peak with adj size 4 108641841 153641841 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 4 106347236 151347236 5 - by peak with adj size 4 106649412 151649412 5 - by peak with adj size 731166 rat Mamtr2 Mammary tumor resistance QTL 2 2 1.0E-4 33822 D2Mit29 67798 D2Uwm14 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 724790 14522903 semidominant 2 5396621 10117085 1 - by flanking markers 2 5601528 10539334 1 - by flanking markers intercross WFxCOP 728387 WF.COP-(D2Mit29-D2Uwm13)/Uwm 2 5417336 10246458 1 - by flanking markers 2 7887772 12654247 1 - by flanking markers 731167 rat Glom4 Glomerulus QTL 4 2 2.4 0.0082 37018 D2Rat14 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 730279 14638907 2 39326015 84326015 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 2 20276981 65276981 5 - by peak with adj size 2 20304672 65304672 5 - by peak with adj size 731168 rat Bp154 Blood pressure QTL 154 1 3.4 2969 Klk1 43424 D1Wox10 621323 Phox2a arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure hypertension 730283 14623828 1 101196673 244066407 1 - by flanking markers 1 94624828 220639653 1 - by flanking markers backcross 731189 SHRSP.WKY-(Klk1-D1Rat116)/Izm 1 100131562 236763528 1 - by flanking markers 1 94642644 214537671 1 - by flanking markers 731169 rat Bp153 Blood pressure QTL 153 1 0.001 37974 D1Rat211 36550 D1Rat12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728381;2312639 14597851;19423552 Bp344 (sub_region) 1 35077728 37526296 1 - by flanking markers 17 1147796 3643283 1 - by flanking markers backcross 731190 SS.LEW-(D1Rat211-D1Rat18)/Mco 1 33667777 36129328 1 - by flanking markers 1 31050840 33492143 1 - by flanking markers 731170 rat Pur3 Proteinuria QTL 3 15 2.3 5.0E-4 37702 D15Rat66 urine protein amount (VT:0005160) urine protein excretion rate (CMO:0000759) increased urine protein level proteinuria 730279 14638907 15 1803102 46803102 5 - by peak with adj size 15 1 44351302 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 15 1 42844179 5 - by peak with adj size 15 1 41686771 5 - by peak with adj size 731171 rat Glom6 Glomerulus QTL 6 9 2.8 3.0E-4 35691 D9Rat5 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 730279 14638907 9 70670941 115670941 5 - by peak with adj size 9 62686917 107686917 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 9 70942881 115942881 5 - by peak with adj size 9 64573531 109573531 5 - by peak with adj size 731172 rat Bp151 Blood pressure QTL 151 3 0.04 10260 D3Rat52 39050 D3Rat130 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 724791;1599557 14517349;17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers backcross 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 731173 rat Uae22 Urinary albumin excretion QTL 22 6 10.1 38608 D6Rat106 36191 D6Rat6 36990 D6Rat12 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279;1642911;1600609 14638907;17953514;17167120 2151;3851;70907 Arg2;Tgfb3;Actn1 6 78348236 132488565 1 - by flanking markers 6 68036028 123455207 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 6 68781170 147991367 2 - by one flank and peak markers 6 65531555 140994061 2 - by one flank and peak markers 731174 rat Uae23 Urinary albumin excretion QTL 23 7 2.4 0.0042 35304 D7Rat4 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 7 114463225 143501887 5 - by peak with adj size 7 112114092 143002779 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 7 114825174 145729302 5 - by peak with adj size 7 104603555 135012528 5 - by peak with adj size 731175 rat Uae20 Urinary albumin excretion QTL 20 1 3.5 0.0018 35909 D1Rat74 35457 D1Rat90 35945 D1Rat75 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 1 248763714 289137268 1 - by flanking markers 1 227005311 267111153 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 1 241482188 281795785 1 - by flanking markers 1 221264111 259647894 1 - by flanking markers 731176 rat Glom5 Glomerulus QTL 5 7 2.5 0.0035 35118 D7Rat7 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 730279 14638907 7 106256195 143501887 5 - by peak with adj size 7 103894800 143002779 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 7 106564316 145729302 5 - by peak with adj size 7 96670164 135012528 5 - by peak with adj size 731177 rat Uae26 Urinary albumin excretion QTL 26 15 2.4 0.025 40106 D15Rat102 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 15 78999675 114627140 5 - by peak with adj size 15 75200650 109758846 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 15 75527634 111246239 5 - by peak with adj size 15 67588667 101769107 5 - by peak with adj size 731178 rat Oia7 Oil induced arthritis QTL 7 4 1.0E-4 60413 D4Got126 60422 D4Got136 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 730281;1642519;2307198 12915467;17665455;18540828 2976;2977;2978;619983;620537;1359528 Klrc1;Klrc2;Klrd1;C1s;C3ar1;Clec4a3 additive 4 222677930 223964695 1 - by flanking markers 4 159298584 160528447 1 - by flanking markers backcross 731193 DA.PVG-(D4Rat141-D4Mgh11) 4 155657051 156945571 1 - by flanking markers 4 156050654 157232313 1 - by flanking markers 731179 rat Mamtr3 Mammary tumor resistance QTL 3 2 1.0E-4 67800 D2Uwm17 36470 D2Rat16 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 407571689;724790 22993404;14522903 recessive 2 50381686 62691053 1 - by flanking markers 2 32051319 43376636 1 - by flanking markers intercross WFxCOP 728391 WF.COP-(D2Rat253-D2Uwm17)/Uwm 2 31224612 43643900 1 - by flanking markers 2 32373770 43665178 1 - by flanking markers 731180 rat Bp152 Blood pressure QTL 152 3 0.03 728034 D3Chm63 35795 D3Rat26 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 724791 14517349 3 61857234 101798901 1 - by flanking markers 3 51161661 90573782 1 - by flanking markers backcross 731194 SS.LEW-(D3Chm64-D3Rat17)/Ayd 3 55245276 95176874 1 - by flanking markers 3 53781112 91609953 1 - by flanking markers 731181 rat Uae27 Urinary albumin excretion QTL 27 X 2.7 0.0059 36111 DXRat8 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 X 1 44359160 5 - by peak with adj size X 18886934 63886934 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub X 1 44092703 5 - by peak with adj size X 1 43491017 5 - by peak with adj size 731182 rat Uae24 Urinary albumin excretion QTL 24 8 6.4 35296 D8Rat53 36904 D8Rat19 36235 D8Rat35 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 8 21869159 100352529 1 - by flanking markers 8 19815642 98451660 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 8 21813070 100873963 1 - by flanking markers 8 19331152 93965294 1 - by flanking markers 731183 rat Pia20 Pristane induced arthritis QTL 20 14 3.55 35713 D14Rat11 37030 D14Rat3 33551 D14Mit6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 730280 14624754 14 10676655 61976011 1 - by flanking markers 14 10340377 41608939 1 - by flanking markers backcross 731195 DA.E3-(D14Wox8-D14Rat64)/Rhd 14 10729268 61873323 1 - by flanking markers 14 9088978 39057237 1 - by flanking markers 731184 rat Mamtr4 Mammary tumor resistance QTL 4 2 3.0E-4 36205 D2Rat2 728007 D2M13Mit286 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 724790 14522903 semidominant 2 14095321 59095321 4 - by one flank marker only 2 14747814 59747814 4 - by one flank marker only intercross WFxCOP 728385 WF.COP-(D2Rat2-D2M13Mit286)/Uwm 2 14237830 59237830 4 - by one flank marker only 2 16491740 61491740 4 - by one flank marker only 734767 rat Niddm57 Non-insulin dependent diabetes mellitus QTL 57 1 37902 D1Rat169 42550 D1Rat459 body mass (VT:0001259) body weight (CMO:0000012) increased body weight;increased circulating cholesterol level Hypercholesterolemia;Hypertriglyceridemia;obesity 619679 11355573 1 251652807 289700417 1 - by flanking markers 1 229876870 267593558 1 - by flanking markers 734527 OLETF.F344-(D1Rat169-D1Rat459)/Got 1 244401175 282365384 1 - by flanking markers 1 224054293 260122809 1 - by flanking markers 734768 rat Niddm59 Non-insulin dependent diabetes mellitus QTL 59 1 40126 D1Rat306 42553 D1Rat461 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;decreased circulating cholesterol level;decreased total body fat amount;decreased triglyceride level obesity;type 2 diabetes mellitus 734465 12190994 1 268967725 288207792 1 - by flanking markers 1 248583506 266234812 1 - by flanking markers 734531 OLETF.F344-(D1Rat306-D1Rat461)/Got 1 235850810 280850810 4 - by one flank marker only 1 213843987 258843987 4 - by one flank marker only 734769 rat Niddm58 Non-insulin dependent diabetes mellitus QTL 58 1 36960 D1Rat76 42550 D1Rat459 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;decreased circulating insulin level;decreased circulating triglyceride level;decreased total body fat amount;improved glucose tolerance Insulin Resistance;obesity;type 2 diabetes mellitus 619683;2312611 11153534;19697080 additive Bw85 (maps to same region) 1 252243728 289700417 1 - by flanking markers 1 230411091 267593558 1 - by flanking markers 734528 OLETF.BN-(D1Rat76-D1Rat459)/Got 1 244992467 282365384 1 - by flanking markers 1 224569538 260122809 1 - by flanking markers 737818 rat Hcar12 Hepatocarcinoma resistance QTL 12 3 2.6 35745 D3Rat48 34411 D3Mgh14 35745 D3Rat48 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566 12154055 Hcar10 (interacts with);Hcar11 (interacts with);Hcar9 (interacts with) 3 35310614 130198834 1 - by flanking markers 3 25775548 118863223 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 3 30114912 123700444 1 - by flanking markers 3 29463235 118376539 1 - by flanking markers 737819 rat Hcas4 Hepatocarcinoma susceptibility QTL 4 16 4.43 33848 D16Mit2 10842 D16Mgh5 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) increased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566 12154055 Hcas3 (interacts with) 16 4954192 49892275 1 - by flanking markers 16 4304396 50266190 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 16 5013802 50169318 1 - by flanking markers 16 4227609 46975965 1 - by flanking markers 737820 rat Alc9 Alcohol consumption QTL 9 10 2.2 34361 D10Mgh25 39082 D10Rat118 41276 D10Rat182 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212;4890458;7401255 14634485;20705418;23596094 2401;61836;1304560;1311614;1359733;1563691 Crebbp;Clcn7;Fahd1;Gnptg;Trap1;Mapk8ip3 additive Alc10 (interacts with);Alc11 (interacts with);Alc12 (maps to same region,interacts with);Alc13 (interacts with);Alc4 (interacts with);Alc5 (maps to same region);Alc6 (interacts with);Alc7 (interacts with);Alc8 (interacts with);Foco17 (maps to same region) 10 4040517 19469666 1 - by flanking markers 10 5090008 19648894 1 - by flanking markers Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 10 5217199 19591669 1 - by flanking markers 10 5144027 19233348 1 - by flanking markers 737821 rat Hcar9 Hepatocarcinoma resistance QTL 9 4 3.7 35817 D4Rat40 34338 D4Mgh11 34174 D4Mgh7 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566 12154055 Hcar10 (interacts with);Hcar11 (interacts with);Hcar12 (interacts with) 4 165920699 230565226 1 - by flanking markers 4 106554769 171204531 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 4 105971071 168047091 2 - by one flank and peak markers 4 109866907 167139601 2 - by one flank and peak markers 737822 rat Alc10 Alcohol consumption QTL 10 12 2.2 11051 D12Mit2 34086 D12Mgh9 36490 D12Rat18 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212;7401255 14634485;23596094 additive Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc4 (interacts with);Alc5 (interacts with);Alc6 (maps to same region);Alc7 (interacts with);Alc8 (interacts with);Alc9 (interacts with);Foco19 (maps to same region);Foco5 (maps to same region);Foco6 (maps to same region) 12 24662983 47758715 1 - by flanking markers 12 20932559 41447890 1 - by flanking markers Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 12 22650702 45946937 1 - by flanking markers 12 19610870 40218516 1 - by flanking markers 737823 rat Alc12 Alcohol consumption QTL 12 10 4.5 41276 D10Rat182 35012 D10Rat46 41524 D10Rat180 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212;7401255 14634485;23596094 additive Alc10 (interacts with);Alc11 (interacts with);Alc13 (interacts with);Alc4 (interacts with);Alc5 (maps to same region);Alc6 (interacts with);Alc7 (interacts with);Alc8 (interacts with);Alc9 (maps to same region,interacts with);Foco17 (maps to same region) 10 17443258 19620793 1 - by flanking markers 10 17515123 19815204 1 - by flanking markers Intercross HAD2xLAD2 731187 731188 Iusm:HAD2 Iusm:LAD2 10 17555386 19743866 1 - by flanking markers 10 17245513 19388279 1 - by flanking markers 737824 rat Hcar10 Hepatocarcinoma resistance QTL 10 8 2.9 36117 D8Rat46 35905 D8Rat21 33973 D8Mit2 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566;737837 12154055 Hcar11 (interacts with);Hcar12 (interacts with);Hcar9 (interacts with) 8 61319409 89073444 1 - by flanking markers 8 43313902 87122960 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 8 44219197 89542960 1 - by flanking markers 8 40713066 82925667 1 - by flanking markers 737825 rat Alc13 Alcohol consumption QTL 13 16 4.5 33848 D16Mit2 37854 D16Rat30 45312 D16Rat124 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212 14634485 additive Alc10 (interacts with);Alc11 (maps to same region);Alc12 (interacts with);Alc4 (interacts with);Alc5 (interacts with);Alc6 (interacts with);Alc7 (maps to same region);Alc8 (interacts with);Alc9 (interacts with) 16 4954192 18239063 1 - by flanking markers 16 4304396 16536977 1 - by flanking markers Intercross HAD2xLAD2 731187 731188 Iusm:HAD2 Iusm:LAD2 16 5013802 18360147 1 - by flanking markers 16 4227609 16039848 1 - by flanking markers 737826 rat Alc11 Alcohol consumption QTL 11 16 3.2 33848 D16Mit2 40234 D16Rat60 34066 D16Mgh1 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212 14634485 additive Alc10 (interacts with);Alc12 (interacts with);Alc13 (maps to same region);Alc4 (interacts with);Alc5 (interacts with);Alc6 (interacts with);Alc7 (maps to same region);Alc8 (interacts with);Alc9 (interacts with) 16 4954192 63674088 1 - by flanking markers 16 4304396 64081533 1 - by flanking markers Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 16 5013802 64012784 1 - by flanking markers 16 4227609 60252231 1 - by flanking markers 737827 rat Hcar11 Hepatocarcinoma resistance QTL 11 6 4.4 34835 D6Rat28 35198 D6Rat11 36665 D6Rat14 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms 629566 12154055 Hcar10 (interacts with);Hcar12 (interacts with);Hcar9 (interacts with) 6 52556973 124634525 1 - by flanking markers 6 41300997 115238799 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 6 86422697 115379601 2 - by one flank and peak markers 6 82523650 110548006 2 - by one flank and peak markers 737828 rat Hcas3 Hepatocarcinoma susceptibility QTL 3 1 4.9 33959 D1Mit3 37982 D1Rat223 35615 D1Rat70 liver integrity trait (VT:0010547) liver tumorous lesion volume to total liver volume ratio (CMO:0001082) increased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566;737884 12154055;15185337 Hcas4 (interacts with) 1 162692213 250573008 1 - by flanking markers 1 146971846 228781113 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 1 156446196 243311614 1 - by flanking markers 1 144267353 222987745 1 - by flanking markers 737856 rat Edpm10 Estrogen-dependent pituitary mass QTL 10 14 2.83 6.5 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 61074 9337394 intercross 10008 61109 BN/SsNHsd F344/NHsd 737973 rat Pia21 Pristane induced arthritis QTL 21 20 4.8 11428 D20Wox3 37594 D20Rat41 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) decreased susceptibility to induced joint inflammation Experimental Arthritis 631850;2307198;2300074;1582387;61031 12817024;18540828;18606636;16804090;10640775 dominant Pia1 (maps to same region) 20 6118863 6935875 1 - by flanking markers 20 3660646 4740814 1 - by flanking markers 737870 DA.E3-(D20Wox3-D20Mgh4)/Rhd 20 4039317 4855475 1 - by flanking markers 20 3621656 4606812 1 - by flanking markers 737974 rat Bp161 Blood pressure QTL 161 1 0.002 10923 D1Wox19 10165 D1Wox34 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 61051 9774356 Bp160 (maps to same region);Bp29 (interacts with) 1 182435183 204942418 1 - by flanking markers 1 168382329 185690881 1 - by flanking markers 629487 SHR.WKY-(D1Wox19-D1Wox34)/Njs 1 175447162 197963658 1 - by flanking markers 1 164747558 181133855 1 - by flanking markers 737975 rat Bw122 Body weight QTL 122 1 9.11 0.005 42553 D1Rat461 42550 D1Rat459 35457 D1Rat90 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 737696 14756694 1 288207586 289700417 1 - by flanking markers 1 266234605 267593558 1 - by flanking markers 737869 OLETF.BN-(D1Rat461-D1Rat459)/Got 1 280850604 282365384 1 - by flanking markers 1 258843780 260122809 1 - by flanking markers 737976 rat Pia24 Pristane induced arthritis QTL 24 6 44173 D6Wox5 37718 D6Rat90 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 728382 14611807 6 126582753 156897508 4 - by one flank marker only 6 117361909 147636619 4 - by one flank marker only 737873 DA.E3-(D6Wox5-D6Rat90)/Rhd 6 117355600 147991367 4 - by one flank marker only 6 112636280 140994061 4 - by one flank marker only 737977 rat Bp160 Blood pressure QTL 160 1 0.001 10923 D1Wox19 34011 D1Mit2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension 61051 9774356 Bp161 (maps to same region);Bp29 (interacts with) 1 204942418 249942418 4 - by one flank marker only 1 134980682 185690881 1 - by flanking markers 629482 WKY.SHR-(D1Wox19-D1Mit2)/Njs 1 197963658 242963658 4 - by one flank marker only 1 181133855 226133855 4 - by one flank marker only 737978 rat Pia23 Pristane induced arthritis QTL 23 4 5.3 10158 D4Arb16 34338 D4Mgh11 36143 D4Rat60 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2300074;1582387 12817024;18606636;16804090 dominant 4 196023944 230565226 1 - by flanking markers 4 133939407 171204531 1 - by flanking markers 737872 DA.E3-(D4Mit16-D4Mgh11)/Rhd 4 131532269 168047091 1 - by flanking markers 4 131730738 167139601 1 - by flanking markers 737979 rat Pia22 Pristane induced arthritis QTL 22 12 53.1 40986 D12Rat72 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 631850;629560;2300074;1582387 12817024;12571866;18606636;16804090 61307 Ncf1 dominant 12 4475957 49475957 5 - by peak with adj size 12 530865 45530865 5 - by peak with adj size 737871 DA.E3-(D12Got46-D12Rat26)/Rhd 12 2475687 47475687 5 - by peak with adj size 12 1 44465750 5 - by peak with adj size 738005 rat Anxrr11 Anxiety related response QTL 11 18 3.4 37568 D18Rat55 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity Hyperkinesis;anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 18 30846397 75846397 5 - by peak with adj size 18 32356601 77356601 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 18 31608424 76608424 5 - by peak with adj size 18 30039813 75039813 5 - by peak with adj size 738006 rat Anxrr14 Anxiety related response QTL 14 1 4.0 3.5E-4 32.0 34074 D1Mgh8 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) abnormal response to new environment 731213 12972953 Anxrr12 (maps to same region);Anxrr13 (interacts with,maps to same region);Anxrr15 (interacts with) 1 147499447 192499447 5 - by peak with adj size 1 133624682 178624682 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 1 141296374 186296374 5 - by peak with adj size 1 130636910 175636910 5 - by peak with adj size 738007 rat Anxrr7 Anxiety related response QTL 7 2 4.4 41300 D2Rat221 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased locomotor activity;increased anxiety-related response anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 2 142866854 187866854 5 - by peak with adj size 2 123254875 168254875 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 2 123456539 168456539 5 - by peak with adj size 2 118189491 163189491 5 - by peak with adj size 738008 rat Hcar14 Hepatocarcinoma resistance QTL 14 18 4.3 38146 D18Rat50 39278 D18Rat44 36816 D18Rat12 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion number (CMO:0001462) decreased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 18 52220612 86114102 1 - by flanking markers 18 53847682 86863412 1 - by flanking markers intercross 60998 70509 COP F344/NRrrc 18 53033494 87080053 1 - by flanking markers 18 51464733 83218561 1 - by flanking markers 738009 rat Sach4 Saccharine consumption QTL 4 4 4.9 1.6E-5 46.0 36540 D4Rat24 10048 D4Mit20 37100 D4Rat52 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) saccharin preference;saccharin preference alcohol use disorder 731213 12972953 3197 Npy Alc14 (maps to same region);Alc15 (interacts with);Alc16 (interacts with,maps to same region);Alc17 (interacts with);Sach5 (interacts with) 4 58395060 221511103 1 - by flanking markers 4 58421110 158108528 1 - by flanking markers intercross WKYxHEP 61103 738038 WKY HEP 4 58640017 154427984 1 - by flanking markers 4 59948935 154902892 1 - by flanking markers 738010 rat Lnnr3 Liver neoplastic nodule remodeling QTL 3 2 2.94 41538 D2Rat199 40786 D2Rat187 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 2 1 60242597 2 - by one flank and peak markers 2 1 41032214 4 - by one flank marker only intercross 60998 70509 COP F344/NRrrc 2 1 41179397 2 - by one flank and peak markers 2 1 41244106 2 - by one flank and peak markers 738011 rat Anxrr9 Anxiety related response QTL 9 8 6.1 35429 D8Rat7 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased locomotor activity;increased anxiety-related response anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with) 8 101323382 132457389 5 - by peak with adj size 8 98332663 129041809 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 8 102051964 133307652 5 - by peak with adj size 8 93535351 123900184 5 - by peak with adj size 738012 rat Anxrr3 Anxiety related response QTL 3 2 3.8 37880 D2Rat94 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) increased anxiety-related response anxiety disorder 737695;737687 14739700;14722724 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with);Stresp2 (interacts with);Stresp3 (interacts with) 2 27052767 72052767 5 - by peak with adj size 2 8682344 53682344 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 2 7893600 52893600 5 - by peak with adj size 2 9023519 54023519 5 - by peak with adj size 738013 rat Alc15 Alcohol consumption QTL 15 2 4.1 2.2E-4 18.0 38466 D2Rat118 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) abnormal alcohol consumption alcohol use disorder 731213 12972953 Alc14 (interacts with);Alc16 (interacts with);Alc17 (interacts with);Sach4 (interacts with);Sach5 (interacts with) 2 217431609 262431609 5 - by peak with adj size 2 192489056 237489056 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 2 199380312 244380312 5 - by peak with adj size 2 184165752 229165752 5 - by peak with adj size 738014 rat Anxrr15 Anxiety related response QTL 15 8 3.6 0.005 32.0 36327 D8Rat2 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) abnormal response to new environment 731213 12972953 Anxrr12 (interacts with);Anxrr13 (interacts with);Anxrr14 (interacts with) 8 103904881 132457389 5 - by peak with adj size 8 100915338 129041809 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 8 104682575 133307652 5 - by peak with adj size 8 95718998 123900184 5 - by peak with adj size 738015 rat Pia9 Pristane induced arthritis QTL 9 4 4.5 0.048 10561 D4Wox20 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 629560;629570;2307198 12571866;11090241;18540828 Pia11 (interacts with) 4 141344184 186344184 5 - by peak with adj size 4 81916057 126916057 5 - by peak with adj size 737859 DA.PVG.1AV1-(D4Mgh17-D4Rat56) 4 76567036 121567036 5 - by peak with adj size 4 80694870 125694870 5 - by peak with adj size 738016 rat Alc16 Alcohol consumption QTL 16 4 3.6 1.5E-4 35.0 36540 D4Rat24 10048 D4Mit20 35070 D4Rat57 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) alcohol preference alcohol use disorder 731213 12972953 3197 Npy Alc14 (maps to same region);Alc15 (interacts with);Alc17 (interacts with);Sach4 (interacts with,maps to same region);Sach5 (interacts with) 4 58395060 221511103 1 - by flanking markers 4 58421110 158108528 1 - by flanking markers intercross WKYxHEP 61103 738038 WKY HEP 4 58640017 154427984 1 - by flanking markers 4 59948935 154902892 1 - by flanking markers 738017 rat Hcas7 Hepatocarcinoma susceptibility QTL 7 15 2.91 38922 D15Rat38 41114 D15Rat89 35350 D15Rat3 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) increased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 15 2310393 57258002 1 - by flanking markers 15 2306220 43057384 2 - by one flank and peak markers intercross 60998 70509 COP F344/NRrrc 15 2327877 53535766 1 - by flanking markers 15 2266368 46921453 1 - by flanking markers 738018 rat Anxrr4 Anxiety related response QTL 4 5 5.1 35348 D5Rat45 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) decreased anxiety-related response anxiety disorder 737695;10053640;737687 14739700;21029000;14722724 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with);Scort27 (maps to same region);Stresp1 (interacts with);Stresp3 (interacts with) 5 140071351 177180328 5 - by peak with adj size 5 136765530 173096209 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 5 136354114 173707219 5 - by peak with adj size 5 130130159 166875058 5 - by peak with adj size 738019 rat Anxrr10 Anxiety related response QTL 10 3 3.9 39912 D3Rat180 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity Hyperkinesis;anxiety disorder 737695 14739700 Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 3 46967386 91967386 5 - by peak with adj size 3 36264666 81264666 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 3 40422921 85422921 5 - by peak with adj size 3 38517803 83517803 5 - by peak with adj size 738020 rat Pia8 Pristane induced arthritis QTL 8 1 4.7 34035 D1Mit15 11144 D1Wox11 34662 D1Mgh2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 629570;2307198;2300074;1582387;2302026 11090241;18540828;18606636;16804090;14674011 dominant Pia31 (maps to same region) 1 3228155 63399376 1 - by flanking markers 1 1595127 64145956 1 - by flanking markers intercross 631161 737950 DXE3/Ztm DA/Ztm 1 1 64407321 2 - by one flank and peak markers 1 1 65833076 2 - by one flank and peak markers 738021 rat Hcar13 Hepatocarcinoma resistance QTL 13 4 4.3 41102 D4Rat151 41578 D4Rat145 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) decreased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 4 1 31425512 4 - by one flank marker only 4 1 29414068 4 - by one flank marker only intercross 60998 70509 COP F344/NRrrc 4 1 31554484 4 - by one flank marker only 4 1 32584199 4 - by one flank marker only 738022 rat Anxrr13 Anxiety related response QTL 13 1 4.6 3.9E-4 24.0 34381 D1Mgh7 locomotor behavior trait (VT:0001392) number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514) abnormal response to new environment 731213 12972953 Anxrr12 (interacts with);Anxrr14 (interacts with,maps to same region);Anxrr15 (interacts with) 1 92100958 137100958 5 - by peak with adj size 1 83945235 128945235 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 1 91093646 136093646 5 - by peak with adj size 1 83547917 128547917 5 - by peak with adj size 738023 rat Alc17 Alcohol consumption QTL 17 6 3.1 0.003 38.0 35963 D6Rat46 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) alcohol preference alcohol use disorder 731213 12972953 Alc14 (interacts with);Alc15 (interacts with);Alc16 (interacts with);Sach4 (interacts with);Sach5 (interacts with) 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 738024 rat Sach5 Saccharine consumption QTL 5 6 3.9 3.9E-4 31.0 40624 D6Rat148 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) saccharin preference;saccharin preference alcohol use disorder 731213 12972953 Alc14 (interacts with);Alc15 (interacts with);Alc16 (interacts with);Alc17 (interacts with);Sach4 (interacts with) 6 9458699 54458699 5 - by peak with adj size 6 1 43326782 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 6 1 44570292 5 - by peak with adj size 6 1 43394190 5 - by peak with adj size 738025 rat Stresp3 Stress response QTL 3 X 4.61 0.0066 40448 DXRat127 10609 DXWox31 41530 DXRat104 stress-related behavior trait (VT:0010451) defensive burying - approach abnormal coping response;increased anxiety-related response 737687 14722724 additive Anxrr3 (interacts with);Anxrr4 (interacts with) X 107760007 154597545 2 - by one flank and peak markers X 124590224 160699376 2 - by one flank and peak markers intercross WKYxF344 61103 70509 WKY F344/NRrrc X 107886746 152409805 1 - by flanking markers X 100567703 150256146 1 - by flanking markers 738026 rat Lnnr5 Liver neoplastic nodule remodeling QTL 5 13 3.29 33733 D13Mit2 40568 D13Rat152 36506 D13Rat32 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 13 69987122 96143898 1 - by flanking markers 13 62072299 94306205 2 - by one flank and peak markers intercross 60998 70509 COP F344/NRrrc 13 65008245 91629354 1 - by flanking markers 13 59874408 85581182 1 - by flanking markers 738027 rat Lnnr6 Liver neoplastic nodule remodeling QTL 6 13 3.3 36506 D13Rat32 40568 D13Rat152 40568 D13Rat152 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 13 85295639 96143898 1 - by flanking markers 13 78189125 111154910 4 - by one flank marker only intercross 60998 70509 COP F344/NRrrc 13 80403559 91629354 1 - by flanking markers 13 74862117 85581182 1 - by flanking markers 738028 rat Anxrr12 Anxiety related response QTL 12 1 4.9 1.0E-5 29.0 34074 D1Mgh8 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) abnormal response to new environment 731213 12972953 Anxrr13 (interacts with);Anxrr14 (maps to same region);Anxrr15 (interacts with) 1 147499447 192499447 5 - by peak with adj size 1 133624682 178624682 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 1 141296374 186296374 5 - by peak with adj size 1 130636910 175636910 5 - by peak with adj size 738029 rat Stresp2 Stress response QTL 2 X 3.4 4.0E-4 39210 DXRat64 10558 DXWox30 40448 DXRat127 stress-related behavior trait (VT:0010451) defensive burying - approach abnormal coping response;increased anxiety-related response 737687 14722724 additive Anxrr3 (interacts with);Anxrr5 (interacts with) X 120192403 143175497 1 - by flanking markers X 11470971 145580610 1 - by flanking markers intercross WKYxF344 61103 70509 WKY F344/NRrrc X 120045041 143145818 1 - by flanking markers X 112934952 138400867 1 - by flanking markers 738030 rat Anxrr8 Anxiety related response QTL 8 7 4.1 38606 D7Rat110 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased locomotor activity;increased anxiety-related response anxiety disorder 737695;10053640 14739700;21029000 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr9 (interacts with);Scort27 (maps to same region) 7 54375321 99375321 5 - by peak with adj size 7 50941627 95941627 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 7 54259512 99259512 5 - by peak with adj size 7 46590070 91590070 5 - by peak with adj size 738031 rat Alc14 Alcohol consumption QTL 14 4 7.6 3.0E-5 61.0 36540 D4Rat24 10048 D4Mit20 37868 D4Rat124 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) alcohol preference alcohol use disorder 731213 12972953 3197 Npy Alc15 (interacts with);Alc16 (maps to same region);Alc17 (interacts with);Sach4 (maps to same region);Sach5 (interacts with) 4 58395060 221511103 1 - by flanking markers 4 58421110 158108528 1 - by flanking markers intercross WKYxHEP 61103 738038 WKY HEP 4 58640017 154427984 1 - by flanking markers 4 59948935 154902892 1 - by flanking markers 738032 rat Hcas5 Hepatocarcinoma susceptibility QTL 5 1 3.12 40486 D1Rat437 36169 D1Rat89 35945 D1Rat75 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) increased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 1 198796985 287349830 1 - by flanking markers 1 180678929 265343617 1 - by flanking markers intercross 60998 70509 COP F344/NRrrc 1 191825895 279986079 1 - by flanking markers 1 176426412 257976495 1 - by flanking markers 738033 rat Anxrr6 Anxiety related response QTL 6 7 4.1 37004 D7Rat181 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) abnormal anxiety-related response anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 7 22193116 67193116 5 - by peak with adj size 7 18504784 63504784 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 7 22168412 67168412 5 - by peak with adj size 7 15573889 60573889 5 - by peak with adj size 738034 rat Anxrr5 Anxiety related response QTL 5 6 5.9 39578 D6Rat117 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) decreased anxiety-related response anxiety disorder 737695;10053640;737687 14739700;21029000;14722724 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with);Srcrt6 (maps to same region);Stresp1 (interacts with);Stresp2 (interacts with) 6 97798491 142798491 5 - by peak with adj size 6 88615514 133615514 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 6 88507712 133507712 5 - by peak with adj size 6 84130881 129130881 5 - by peak with adj size 738035 rat Stresp1 Stress response QTL 1 X 4.96 1.1E-5 38374 DXRat67 39210 DXRat64 38374 DXRat67 stress-related behavior trait (VT:0010451) defensive burying - coping abnormal coping response;increased anxiety-related response 737687 14722724 Anxrr4 (interacts with);Anxrr5 (interacts with) X 44859631 120192631 1 - by flanking markers X 11471200 62951569 1 - by flanking markers intercross WKYxF344 61103 70509 WKY F344/NRrrc X 44557974 120045269 1 - by flanking markers X 41304447 112935181 1 - by flanking markers 738036 rat Lnnr4 Liver neoplastic nodule remodeling QTL 4 13 3.64 35543 D13Rat21 35975 D13Rat7 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 13 1 52710812 2 - by one flank and peak markers 13 1 43835207 2 - by one flank and peak markers intercross 60998 70509 COP F344/NRrrc 13 1 47622148 2 - by one flank and peak markers 13 1 42356786 2 - by one flank and peak markers 738037 rat Hcas6 Hepatocarcinoma susceptibility QTL 6 14 2.93 35713 D14Rat11 41138 D14Rat94 37828 D14Rat39 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) increased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 14 61976011 88669930 1 - by flanking markers 14 41608939 89192873 1 - by flanking markers intercross 60998 70509 COP F344/NRrrc 14 61873323 88870994 1 - by flanking markers 14 39057237 83368335 1 - by flanking markers 1298065 rat Scl16 Serum cholesterol level QTL 16 8 3.8 7.0 41026 D8Rat153 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2016 Acat1 8 33617573 78617573 5 - by peak with adj size 8 33897608 78897608 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 8 35041414 80041414 5 - by peak with adj size 8 30856404 75856404 5 - by peak with adj size 1298066 rat Bp159 Blood pressure QTL 159 13 0.004 3804 Syt2 61281 D13M1Mit108 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure;increased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension;hypertension 61047;61040 9271663;9685318 13 56621954 101621954 4 - by one flank marker only 13 47690518 92690518 4 - by one flank marker only 737864 SS.SR-(D13Mit9-D13Mit1)/Jr 13 51569248 96569248 4 - by one flank marker only 13 46088046 91088046 4 - by one flank marker only 1298067 rat Scl15 Serum cholesterol level QTL 15 5 4.8 0.001 10.0 33678 D5Mit10 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 5 38938687 83938687 5 - by peak with adj size 5 35474610 80474610 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 5 34402409 79402409 5 - by peak with adj size 5 33215665 78215665 5 - by peak with adj size 1298068 rat Bp167 Blood pressure QTL 167 3 0.004 2534 Edn3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61042 7963489 2534 Edn3 3 156414290 183740530 5 - by peak with adj size 3 144002709 171063335 5 - by peak with adj size 10040 10041 SR/Jr SS/Jr 3 150368003 177699992 5 - by peak with adj size 3 141074471 169034231 5 - by peak with adj size 1298069 rat Bp168 Blood pressure QTL 168 10 5.5 33632 D10Mit10 66563 D10Mco6 44786 D10Wox6 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040 9685318 3185 Nos2 10 27082535 101157704 1 - by flanking markers 10 27184741 102587587 1 - by flanking markers 10041 60999 SS/Jr LEW 10 27237530 101482600 1 - by flanking markers 10 26521957 98003205 1 - by flanking markers 1298070 rat Scl18 Serum cholesterol level QTL 18 5 3.7 7.0 35074 D5Rat23 blood LDL cholesterol amount (VT:0000181) calculated plasma low density lipoprotein cholesterol level (CMO:0001245) increased circulating LDL cholesterol level Hypercholesterolemia 737694 14739155 728889 Plin2 5 87410667 132410667 5 - by peak with adj size 5 84392127 129392127 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 5 83424556 128424556 5 - by peak with adj size 5 79584860 124584860 5 - by peak with adj size 1298071 rat Edpm12 Estrogen-dependent pituitary mass QTL 12 X 3.2 36301 DXRat9 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 629550 11003699 X 4687646 49687646 5 - by peak with adj size X 23620000 68620000 5 - by peak with adj size backcross 10008 61109 BN/SsNHsd F344/NHsd X 4282140 49282140 5 - by peak with adj size X 2927898 47927898 5 - by peak with adj size 1298072 rat Cia26 Collagen induced arthritis QTL 26 18 3.6 33814 D18Mit9 37488 D18Rat60 33814 D18Mit9 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 1285224;2307198;2300074;1582387 15334486;18540828;18606636;16804090 recessive Cia7 (interacts with) 18 57248312 87229863 5 - by peak with adj size 18 57870442 87265094 5 - by peak with adj size intercross 631182 737892 DA/BklArbN ACI/SegHsd 18 58196300 88201929 5 - by peak with adj size 18 54709769 83828827 5 - by peak with adj size 1298073 rat Cm13 Cardiac mass QTL 13 3 2.5 37510 D3Rat100 66449 D3Mco16 60801 D3Wox3 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight;increased systemic arterial blood pressure hypertension 69705 9922389 3 30841048 44344790 1 - by flanking markers 3 21201203 35237920 1 - by flanking markers 10040 10041 SR/Jr SS/Jr 3 25633366 39248391 1 - by flanking markers 3 25013911 38192233 1 - by flanking markers 1298074 rat Bp164 Blood pressure QTL 164 2 0.003 37018 D2Rat14 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728179 11980293 Bp165 (maps to same region) 2 61825950 235592880 1 - by flanking markers 2 165636169 210636169 4 - by one flank marker only 731191 SHRSP.WKY-(D2Rat14-D2Mgh12)/Gcrc 2 42776916 217498710 1 - by flanking markers 2 42804607 202447032 1 - by flanking markers 1298075 rat Scl17 Serum cholesterol level QTL 17 2 3.4 7.0 34864 D2Rat67 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 1298076 rat Bp166 Blood pressure QTL 166 2 9.0E-4 60798 D2Wox9 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728179 11980293 2756 Gstm2 Bp14 (maps to same region) 2 161271919 235592880 1 - by flanking markers 2 141259937 210636169 1 - by flanking markers 737863 SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc 2 141583337 217498710 1 - by flanking markers 2 136445150 202447032 1 - by flanking markers 1298077 rat Bp157 Blood pressure QTL 157 5 39600 D5Rat154 62518 D5Uia8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 619649;1643012;7495753 11875185;17938377;23757393 3170 Nfia Bp373 (sub_region) 5 79025214 124025214 4 - by one flank marker only 5 76964552 121964552 4 - by one flank marker only 728145 SS.LEW-(D5Rat130-D5Rat108)/Jr 1298078 rat Stresp5 Stress response QTL 5 10 2.99 2.5E-4 9.0 41394 D10Rat164 41584 D10Rat135 35256 D10Rat11 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 737981 15013833 10 43088682 108145987 1 - by flanking markers 10 43458380 108776963 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 10 43289657 108540162 1 - by flanking markers 10 42045676 104670812 1 - by flanking markers 1298079 rat Activ2 Activity QTL 2 8 9.5 1.0E-6 29.0 33858 D8Mit4 10169 D8Wox11 voluntary movement trait (VT:0003491) rearing measurement (CMO:0001515) increased exploration in new environment Hyperkinesis 631228 12660808 62388 Htr5b Activ1 (maps to same region) 8 44187546 89187546 4 - by one flank marker only 8 44484215 129041809 2 - by one flank and peak markers 61103 68186 WKY WKHA/N 8 45712344 90712344 4 - by one flank marker only 8 41866876 86866876 4 - by one flank marker only 1298080 rat Bp163 Blood pressure QTL 163 2 0.02 33739 D2Mit5 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased heart weight;increased systemic arterial blood pressure hypertension;hypertension 68910;69705;2301356 10642295;9922389;18819818 Bp132 (interacts with) 2 86560119 235592880 1 - by flanking markers 2 66680022 210636169 1 - by flanking markers 631280 WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc 2 66828049 217498710 1 - by flanking markers 2 66118275 202447032 1 - by flanking markers 1298081 rat Cia25 Collagen induced arthritis QTL 25 12 4.7 11053 D12Wox12 41962 D12Arb6 11053 D12Wox12 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 1285224;1600250;2300074;1582387;2307198 15334486;17329308;18606636;16804090;18540828 61307 Ncf1 recessive Cia12 (maps to same region) 12 24663002 43150909 1 - by flanking markers 12 20932555 36894750 1 - by flanking markers intercross 631182 737892 DA/BklArbN ACI/SegHsd 12 22650721 41291738 1 - by flanking markers 12 19610889 35682913 1 - by flanking markers 1298082 rat Stresp4 Stress response QTL 4 4 34967 D4Rat15 36143 D4Rat60 36870 D4Rat33 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 737981 15013833 4 46704280 208908285 1 - by flanking markers 4 47889730 149560340 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 4 46898276 145611886 1 - by flanking markers 4 50119848 146803430 1 - by flanking markers 1298083 rat Bp158 Blood pressure QTL 158 2 2.62 2167 Atp1a1 2263 Camk2d arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61038;61037 8040284;1363813 2 223440514 250484590 1 - by flanking markers 2 196657749 224108082 1 - by flanking markers 10041 60992 SS/Jr MNS 2 204003742 231132207 1 - by flanking markers 2 189020722 215287351 1 - by flanking markers 1298084 rat Thym4 Thymus enlargement QTL 4 1 10.68 2870 Igf2 11201 D1Mgh11 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) enlarged thymus Thymus Hyperplasia 70859 10792781 Thym1 (sub_region) 1 222722921 267722921 4 - by one flank marker only 1 202906624 247906624 4 - by one flank marker only 61118 61119 BUF/Mna WKY/NCrlCrlj 1 215828102 260828102 4 - by one flank marker only 1 197814409 242814409 4 - by one flank marker only 1298085 rat Bp165 Blood pressure QTL 165 2 6.0E-4 37018 D2Rat14 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728179 11980293 Bp164 (maps to same region) 2 61825950 235592880 1 - by flanking markers 2 165636169 210636169 4 - by one flank marker only 737865 WKY.SHRSP-(D2Rat14-D2Mgh12) 2 42776916 217498710 1 - by flanking markers 2 42804607 202447032 1 - by flanking markers 1298086 rat Bp156 Blood pressure QTL 156 5 69549 D5Uwm31 34583 D5Rjr1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 619649;1643012;7495753 11875185;17938377;23757393 1308173 Dmrta2 Bp372 (sub_region) 5 93293117 138293117 4 - by one flank marker only 5 90916908 135916908 4 - by one flank marker only 728145 SS.LEW-(D5Rat130-D5Rat108)/Jr 5 89502294 134502294 4 - by one flank marker only 5 84132602 129132602 4 - by one flank marker only 1298087 rat Iddm18 Insulin dependent diabetes mellitus QTL 18 6 1.0E-4 42809 D6Rat184 39052 D6Rat101 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) increased body weight;increased circulating cholesterol level;increased circulating triglyceride level type 1 diabetes mellitus 619685 11327715 6 130448688 144756005 1 - by flanking markers 6 121381065 135964844 1 - by flanking markers 1549799 BB.SHR-(D6Rat184-D6Rat3)/K 6 121224054 135658578 1 - by flanking markers 6 116506292 130245370 1 - by flanking markers 1298088 rat Edpm11 Estrogen-dependent pituitary mass QTL 11 9 2.5 36157 D9Rat31 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) impaired basement membrane formation;pituitary gland hyperplasia Pituitary Neoplasms 629550 11003699 9 1217127 46217127 5 - by peak with adj size 9 1 39963583 5 - by peak with adj size backcross 10008 61109 BN/SsNHsd F344/NHsd 9 2355722 47355722 5 - by peak with adj size 9 1 43718459 5 - by peak with adj size 1298089 rat Scl14 Serum cholesterol level QTL 14 5 5.8 4.0E-4 12.0 33680 D5Mit13 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2479;3642 Cyp4a2;Scp2 5 117929881 162929881 5 - by peak with adj size 5 115772027 160772027 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 5 114140832 159140832 5 - by peak with adj size 5 108845856 153845856 5 - by peak with adj size 1298090 rat Bp155 Blood pressure QTL 155 5 3.8 58.5 34206 D5Mgh15 34168 D5Mgh22 11002 D5Mit15 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 731210 14678232 3193;3194 Nppa;Nppb Cm24 (maps to same region);Lanf1 (maps to same region);Strs2 (maps to same region) 5 160953783 171364494 1 - by flanking markers 5 157584492 167844579 1 - by flanking markers 70454 728194 WKY/N SHR/N 5 157212422 167739539 1 - by flanking markers 5 151006154 161165494 1 - by flanking markers 1298524 rat Oia8 Oil induced arthritis QTL 8 4 34174 D4Mgh7 33778 D4Mit21 34473 D4Mgh10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 629560 12571866 RA20_H (maps to syntenic region) 4 200825021 244267149 2 - by one flank and peak markers 4 136668162 181668162 5 - by peak with adj size 737861 DA.PVG.1AV1-(D4Rat63-D4Rat203) 4 136351734 174694858 2 - by one flank and peak markers 4 138503169 173369699 2 - by one flank and peak markers 1298525 rat Cm1 Cardiac mass QTL 1 7 2.7 62494 D7Uia1 66593 D7Mco1 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight Cardiomegaly;hypertension 69710 9383281 7 108833186 112367543 1 - by flanking markers 7 105412922 108875615 1 - by flanking markers 10040 10041 SR/Jr SS/Jr 7 108889614 112429186 1 - by flanking markers 7 99736187 103146217 1 - by flanking markers 1298526 rat Arunc3 Aerobic running capacity QTL 3 3 2.2 35981 D3Rat56 38346 D3Rat98 35981 D3Rat56 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) decreased aerobic running capacity;increased aerobic running capacity 619535;1547852 12079278;16033863 735225;1305546;1309048;1311721 Serping1;Anapc2;Snapc4;Nmi dominant Arunc2 (interacts with) 3 2612834 38637167 1 - by flanking markers 3 3577905 30254280 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 3 2631421 33477544 1 - by flanking markers 3 8227194 33703538 1 - by flanking markers 1298527 rat Arunc2 Aerobic running capacity QTL 2 16 2.9 37174 D16Rat42 36608 D16Rat48 41324 D16Rat55 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) decreased aerobic running capacity;increased aerobic running capacity 619535;1547852 12079278;16033863 2015;69316;620427;628670;1306769 Acsl1;Irs2;Pdlim3;Ppif;Tm2d2 dominant Arunc3 (interacts with) 16 72850762 79690408 2 - by one flank and peak markers 16 73394189 79850195 2 - by one flank and peak markers 10011 734475 COP/OlaHsd DA/OlaHsd 16 73219638 80115794 2 - by one flank and peak markers 16 68532716 75029966 2 - by one flank and peak markers 1298528 rat Bp169 Blood pressure QTL 169 7 1.0E-4 66604 D7Mco7 39956 D7Rat131 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 69711;629613 11247666;12682779 Bp335 (sub_region);Bp61 (maps to same region);Bpq6_m (maps to syntenic region) 7 115335186 116059683 1 - by flanking markers 7 111882577 112979256 1 - by flanking markers 1299868 SS.SR-(D7Uia1-D7Mco7)/Jr 7 70421228 115421228 4 - by one flank marker only 7 61074194 106074194 4 - by one flank marker only 1298529 rat Arunc1 Aerobic running capacity QTL 1 16 4.0 35280 D16Rat19 39838 D16Rat109 37054 D16Rat17 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) decreased aerobic running capacity;increased aerobic running capacity 619535;1547852 12079278;16033863 2015;2061;3199;69316;620427;628670;1306769 Acsl1;Adrb3;Npy5r;Irs2;Pdlim3;Ppif;Tm2d2 dominant 16 35126908 63570711 1 - by flanking markers 16 35339929 63977788 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 16 35307110 63909364 1 - by flanking markers 16 31951520 60148445 1 - by flanking markers 1300075 rat Glom7 Glomerulus QTL 7 6 5.6 2.0E-7 33987 D6Mit8 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria 730279 14638907 6 84871080 129871080 5 - by peak with adj size 6 75061972 120061972 5 - by peak with adj size 731185 731186 MWF/Fub SHR/Fub 6 75449871 120449871 5 - by peak with adj size 6 71201409 116201409 5 - by peak with adj size 1300076 rat Glom8 Glomerulus QTL 8 6 7.0 9.0E-9 36990 D6Rat12 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) abnormal renal glomerulus morphology Albuminuria 730279 14638907 6 100970063 145970063 5 - by peak with adj size 6 91532057 136532057 5 - by peak with adj size 731185 731186 MWF/Fub SHR/Fub 6 91703409 136703409 5 - by peak with adj size 6 86894788 131894788 5 - by peak with adj size 1300107 rat Rf18 Renal function QTL 18 10 3.41 39226 D10Rat86 40488 D10Rat201 34896 D10Rat17 urine output (VT:0003620) timed urine volume (CMO:0000260) abnormal urine homeostasis;polyuria Polyuria;kidney disease 727992 14532335 10 81346666 101432356 1 - by flanking markers 10 82474813 102865929 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 81515116 101758478 1 - by flanking markers 10 78775516 98279596 1 - by flanking markers 1300108 rat Rf8 Renal function QTL 8 1 3.75 40028 D1Rat301 35457 D1Rat90 35457 D1Rat90 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;decreased renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 727992 14532335 Rf6 (interacts with);Rf7 (interacts with) 1 256444932 289137268 1 - by flanking markers 1 234595190 267111153 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 249206242 281795785 1 - by flanking markers 1 228581588 259647894 1 - by flanking markers 1300109 rat Rf13 Renal function QTL 13 4 3.91 35879 D4Rat67 36655 D4Rat70 39414 D4Rat204 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 4 224440904 248343840 2 - by one flank and peak markers 4 161028988 184893756 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 157423126 184226339 2 - by one flank and peak markers 4 157710145 182687754 2 - by one flank and peak markers 1300110 rat Stl7 Serum triglyceride level QTL 7 11 4.64 35483 D11Rat15 10375 D11Mgh1 35955 D11Rat38 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) abnormal circulating creatinine level;increased circulating triglyceride level;increased systemic arterial blood pressure Hypertriglyceridemia 727992 14532335 11 34054821 89808503 1 - by flanking markers 11 29744366 84560241 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 30435339 86714631 1 - by flanking markers 11 29528418 82566702 1 - by flanking markers 1300111 rat Rf12 Renal function QTL 12 3 3.78 39912 D3Rat180 36717 D3Rat17 40016 D3Rat168 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal glomerulus morphology;abnormal renal plasma flow rate;increased systemic arterial blood pressure;kidney inflammation hypertension;kidney disease 727992 14532335 Kidm4 (interacts with);Rf10 (interacts with);Rf11 (maps to same region) 3 69467333 133513825 1 - by flanking markers 3 58764506 121619110 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 62922868 127023997 1 - by flanking markers 3 61017749 121056321 1 - by flanking markers 1300112 rat Bp183 Blood pressure QTL 183 7 3.51 35559 D7Rat13 37774 D7Rat80 37774 D7Rat80 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 7 126904511 141946865 1 - by flanking markers 7 124315012 141301748 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 121654760 145729302 5 - by peak with adj size 7 111182207 135012528 5 - by peak with adj size 1300113 rat Bp176 Blood pressure QTL 176 3 3.9 36584 D3Rat6 40676 D3Rat142 37980 D3Rat114 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal kidney size;increased systemic arterial blood pressure hypertension 727992 14532335 Bp177 (interacts with) 3 158307259 171495734 1 - by flanking markers 3 147990566 159769019 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 153412455 165355668 1 - by flanking markers 3 145956084 157309487 1 - by flanking markers 1300114 rat Srn2 Serum renin concentration QTL 2 14 3.27 36536 D14Rat1 41990 D14Arb16 35965 D14Rat6 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal renin activity kidney disease 727992 14532335 14 4830815 22901310 1 - by flanking markers 14 4895894 22837299 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 4833233 23004027 1 - by flanking markers 14 3813074 21217635 1 - by flanking markers 1300115 rat Hrtrt7 Heart rate QTL 7 5 2.76 36279 D5Rat4 40992 D5Rat148 34216 D5Mgh6 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Bp180 (interacts with);Hrtrt8 (interacts with) 5 53302456 92225914 1 - by flanking markers 5 49767270 89261520 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 48722038 93587756 2 - by one flank and peak markers 5 47869062 90099692 2 - by one flank and peak markers 1300116 rat Hrtrt5 Heart rate QTL 5 4 3.76 38344 D4Rat106 41568 D4Rat200 34174 D4Mgh7 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt6 (interacts with) 4 179959725 215966084 1 - by flanking markers 4 117887605 154283969 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 115372758 150038284 1 - by flanking markers 4 116179486 151161268 1 - by flanking markers 1300117 rat Hrtrt8 Heart rate QTL 8 5 3.49 39686 D5Rat119 36279 D5Rat4 36618 D5Rat2 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased circulating triglyceride level;increased systemic arterial blood pressure Hypertriglyceridemia 727992 14532335 Bp180 (interacts with);Hrtrt7 (interacts with) 5 3239567 53302606 1 - by flanking markers 5 2965857 49767421 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 3251329 48722188 1 - by flanking markers 5 3844018 47869213 1 - by flanking markers 1300118 rat Bp190 Blood pressure QTL 190 15 2.94 34409 D15Mgh9 40516 D15Rat106 40516 D15Rat106 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 727992 14532335 15 93131834 109944957 1 - by flanking markers 15 89569706 106177917 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 89640684 106550657 1 - by flanking markers 15 82262520 98288169 1 - by flanking markers 1300119 rat Bp180 Blood pressure QTL 180 5 3.82 39176 D5Rat103 41798 D5Rat246 39168 D5Rat99 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Hrtrt7 (interacts with);Hrtrt8 (interacts with) 5 154014163 168107673 2 - by one flank and peak markers 5 151039725 164343989 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 150340838 164298744 2 - by one flank and peak markers 5 144358090 157869054 2 - by one flank and peak markers 1300120 rat Kidm7 Kidney mass QTL 7 15 3.55 34409 D15Mgh9 40516 D15Rat106 35497 D15Rat25 kidney mass (VT:0002707) left kidney wet weight to body weight ratio (CMO:0001954) abnormal kidney weight;abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 15 93131834 109944957 1 - by flanking markers 15 89569706 106177917 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 89640684 106550657 1 - by flanking markers 15 82262520 98288169 1 - by flanking markers 1300121 rat Hrtrt1 Heart rate QTL 1 1 3.7 34037 D1Mit1 35166 D1Rat33 41374 D1Rat265 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt2 (maps to same region) 1 67159157 123747809 2 - by one flank and peak markers 1 64744882 116153262 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 66113339 122614963 2 - by one flank and peak markers 1 65789093 115540829 2 - by one flank and peak markers 1300122 rat Wbc1 White blood cell count QTL 1 5 2.75 40992 D5Rat148 38510 D5Rat63 38828 D5Rat90 leukocyte quantity (VT:0000217) total white blood cell count (CMO:0000365) abnormal leukocyte cell number;increased leukocyte cell number Inflammation;heart disease 727992 14532335 5 92225721 149494629 1 - by flanking markers 5 89261341 147065912 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 130531300 145726262 2 - by one flank and peak markers 5 125392826 139989768 2 - by one flank and peak markers 1300123 rat Bp194 Blood pressure QTL 194 17 2.82 35116 D17Rat53 35697 D17Rat16 38348 D17Rat59 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 17 512253 37591626 1 - by flanking markers 17 7696509 41028541 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 519770 36283402 1 - by flanking markers 17 2115149 34551001 1 - by flanking markers 1300124 rat Cm4 Cardiac mass QTL 4 9 3.55 38604 D9Rat101 35819 D9Rat26 40170 D9Rat135 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) abnormal heart size;abnormal renal plasma flow rate;increased systemic arterial blood pressure Cardiomegaly;hypertension 727992 14532335 9 1 44725204 2 - by one flank and peak markers 9 1 37313370 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 9 1 45029794 2 - by one flank and peak markers 9 1 40594091 2 - by one flank and peak markers 1300125 rat Rf26 Renal function QTL 26 18 3.2 34182 D18Mgh3 37568 D18Rat55 39610 D18Rat91 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) decreased urine potassium level kidney disease 727992 14532335 18 53346447 66665061 1 - by flanking markers 18 54856651 69013303 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 54108474 67502122 1 - by flanking markers 18 52539863 65844950 1 - by flanking markers 1300126 rat Bp175 Blood pressure QTL 175 2 3.46 35290 D2Rat60 36241 D2Rat72 34858 D2Rat69 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;kidney inflammation hypertension 727992;10755344 14532335;22912817 Bp174 (maps to same region);Bp389 (maps to same region) 2 248961074 283538297 1 - by flanking markers 2 222939299 256217383 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 229606682 264899009 1 - by flanking markers 2 214226044 247136170 1 - by flanking markers 1300127 rat Srn1 Serum renin concentration QTL 1 7 3.87 36691 D7Rat27 41186 D7Rat139 38794 D7Rat73 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal renin activity kidney disease 727992 14532335 7 35931747 93795816 1 - by flanking markers 7 32004504 89945095 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 35867729 93155402 1 - by flanking markers 7 29409683 84928080 1 - by flanking markers 1300128 rat Rf16 Renal function QTL 16 6 3.89 35963 D6Rat46 35396 D6Rat35 39124 D6Rat62 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased renal plasma flow rate kidney disease 727992 14532335 6 23080221 44141213 1 - by flanking markers 6 13286615 35233017 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 13122958 34367603 1 - by flanking markers 6 5074497 34434305 1 - by flanking markers 1300129 rat Rf25 Renal function QTL 25 17 3.03 35274 D17Rat45 35827 D17Rat52 35687 D17Rat47 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) abnormal circulating creatinine level;abnormal renal filtration rate;decreased creatinine clearance kidney disease 727992 14532335 17 76512693 86907303 1 - by flanking markers 17 82277326 92594341 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 74852630 85183543 1 - by flanking markers 17 71003325 81153923 1 - by flanking markers 1300130 rat Rf20 Renal function QTL 20 11 4.44 35483 D11Rat15 35955 D11Rat38 40546 D11Rat71 kidney glomerulus integrity trait (VT:0010546) kidney glomerulus diameter (CMO:0001166) abnormal renal glomerulus morphology;increased systemic arterial blood pressure;kidney inflammation focal segmental glomerulosclerosis;hypertension 727992 14532335 11 34054821 66314226 1 - by flanking markers 11 29744366 62045696 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 30435339 63186373 1 - by flanking markers 11 29528418 60324829 1 - by flanking markers 1300131 rat Bp193 Blood pressure QTL 193 17 3.3 35258 D17Rat36 35687 D17Rat47 35274 D17Rat45 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 17 68744780 79573336 1 - by flanking markers 17 74663818 85072478 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 67004212 77922655 1 - by flanking markers 17 63640009 73951021 1 - by flanking markers 1300132 rat Bp182 Blood pressure QTL 182 7 3.49 35068 D7Rat32 41186 D7Rat139 38794 D7Rat73 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Bp181 (interacts with) 7 25506703 93795816 1 - by flanking markers 7 21790655 89945095 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 25365633 93155402 1 - by flanking markers 7 19654317 84928080 1 - by flanking markers 1300133 rat Rf24 Renal function QTL 24 16 3.64 40724 D16Rat87 39586 D16Rat76 40724 D16Rat87 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) abnormal circulating creatinine level;abnormal renal filtration rate;increased systemic arterial blood pressure hypertension 727992 14532335 16 4082652 22994297 1 - by flanking markers 16 3464719 22979073 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 16 4136355 23105837 1 - by flanking markers 16 3380150 21361552 1 - by flanking markers 1300134 rat Bp185 Blood pressure QTL 185 9 3.73 34815 D9Rat16 39380 D9Rat108 36908 D9Rat4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 9 66570118 112478017 1 - by flanking markers 9 58516719 103918256 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 9 66757444 112943287 1 - by flanking markers 9 61381434 104821652 1 - by flanking markers 1300135 rat Rf19 Renal function QTL 19 11 3.38 40546 D11Rat71 10375 D11Mgh1 36065 D11Rat6 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) abnormal circulating creatinine level;abnormal renal filtration rate;decreased urine protein level;increased systemic arterial blood pressure hypertension;proteinuria 727992 14532335 11 46280029 89808503 1 - by flanking markers 11 41711171 84560241 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 43090338 86714631 1 - by flanking markers 11 40946188 82566702 1 - by flanking markers 1300136 rat Rf22 Renal function QTL 22 14 3.9 35319 D14Rat16 40140 D14Rat95 40852 D14Rat90 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 727992 14532335 14 43697829 104803539 1 - by flanking markers 14 44934410 101647208 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 43910761 105074364 1 - by flanking markers 14 42262529 95023211 1 - by flanking markers 1300137 rat Bp186 Blood pressure QTL 186 10 3.57 34896 D10Rat17 35254 D10Rat2 35254 D10Rat2 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 10 93641751 110568670 1 - by flanking markers 10 95066219 110718848 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 93886117 110992275 1 - by flanking markers 10 90627439 107057807 1 - by flanking markers 1300138 rat Hrtrt9 Heart rate QTL 9 7 4.72 36691 D7Rat27 38794 D7Rat73 42215 D7Arb16 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;abnormal urine homeostasis;increased systemic arterial blood pressure hypertension 727992 14532335 7 35931747 61045154 1 - by flanking markers 7 32004504 57326584 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 35867729 61047824 1 - by flanking markers 7 29409683 53612950 1 - by flanking markers 1300139 rat Hrtrt6 Heart rate QTL 6 4 2.85 34238 D4Mgh2 38344 D4Rat106 41200 D4Rat169 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt5 (interacts with) 4 37552221 179959894 1 - by flanking markers 4 36611842 117887968 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 37703272 115372927 1 - by flanking markers 4 39524264 116179656 1 - by flanking markers 1300140 rat Srn3 Serum renin concentration QTL 3 14 3.19 35965 D14Rat6 34965 D14Rat10 36520 D14Rat7 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal renin activity kidney disease 727992 14532335 14 16262980 32957654 1 - by flanking markers 14 16432517 33157602 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 16336988 33163485 1 - by flanking markers 14 14875168 30883947 1 - by flanking markers 1300141 rat Bp178 Blood pressure QTL 178 4 36504 D4Rat2 34238 D4Mgh2 38908 D4Rat126 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 Bp179 (maps to same region) 4 6590796 37552486 1 - by flanking markers 4 5437007 36612108 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 6572939 37703537 1 - by flanking markers 4 10024901 39524530 1 - by flanking markers 1300142 rat Bp191 Blood pressure QTL 191 15 3.14 40434 D15Rat114 38696 D15Rat75 40434 D15Rat114 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 15 1 16828048 4 - by one flank marker only 15 1 14324156 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 1 12800829 4 - by one flank marker only 1300143 rat Rf14 Renal function QTL 14 6 2.92 35396 D6Rat35 41416 D6Rat126 36586 D6Rat26 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased creatinine clearance kidney disease 727992 14532335 6 44141046 90014325 1 - by flanking markers 6 35232849 80102311 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 34367436 80490628 1 - by flanking markers 6 34434137 77102317 1 - by flanking markers 1300144 rat Rf23 Renal function QTL 23 15 3.61 34910 D15Rat14 40516 D15Rat106 34409 D15Mgh9 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 727992 14532335 15 48493430 109944957 1 - by flanking markers 15 45870097 106177917 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 43097470 106550657 1 - by flanking markers 15 40631268 98288169 1 - by flanking markers 1300145 rat Rf7 Renal function QTL 7 1 2.96 37556 D1Rat130 35909 D1Rat74 40230 D1Rat295 urine creatinine amount (VT:0010540) urine creatinine level (CMO:0000125) abnormal renal filtration rate;decreased creatinine clearance kidney disease 727992 14532335 Rf8 (interacts with) 1 208178542 248763894 1 - by flanking markers 1 189900686 227005733 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 201146802 241482368 1 - by flanking markers 1 185145134 221264292 1 - by flanking markers 1300146 rat Rf17 Renal function QTL 17 8 2.9 35663 D8Rat51 41122 D8Rat159 36673 D8Rat49 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased renal plasma flow rate kidney disease 727992 14532335 8 30947236 75947236 4 - by one flank marker only 8 29559446 74559446 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 30918112 75918112 4 - by one flank marker only 8 28242912 73242912 4 - by one flank marker only 1300147 rat Bp187 Blood pressure QTL 187 11 3.67 35957 D11Rat22 41256 D11Rat61 35483 D11Rat15 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 11 11251738 75797949 1 - by flanking markers 11 9053659 50435443 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 1 72720192 2 - by one flank and peak markers 11 1 69446234 2 - by one flank and peak markers 1300148 rat Bp192 Blood pressure QTL 192 17 3.47 35697 D17Rat16 35687 D17Rat47 35258 D17Rat36 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 17 37591469 79573336 1 - by flanking markers 17 41028379 85072478 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 36283245 77922655 1 - by flanking markers 17 34550843 73951021 1 - by flanking markers 1300149 rat Cm6 Cardiac mass QTL 6 7 4.09 41130 D7Rat136 42215 D7Arb16 35068 D7Rat32 heart mass (VT:0007028) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart size;abnormal heart ventricle morphology;abnormal hematocrit;abnormal leukocyte cell number Cardiomegaly 727992 14532335 7 51264916 111529342 1 - by flanking markers 7 47145774 107950815 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 51252005 111589099 1 - by flanking markers 7 43747099 102228765 1 - by flanking markers 1300150 rat Cm3 Cardiac mass QTL 3 8 3.97 41454 D8Rat149 36161 D8Rat36 41122 D8Rat159 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) abnormal heart size Cardiomegaly 727992 14532335 8 57006953 58297648 1 - by flanking markers 8 57308742 58692901 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 58425679 59716199 1 - by flanking markers 8 54237814 55523877 1 - by flanking markers 1300151 rat Bp181 Blood pressure QTL 181 7 3.36 38794 D7Rat73 40966 D7Rat133 41186 D7Rat139 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 Bp182 (interacts with) 7 61044919 113165396 1 - by flanking markers 7 57326196 109727159 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 61047589 113228378 1 - by flanking markers 7 53612714 103945643 1 - by flanking markers 1300152 rat Bp195 Blood pressure QTL 195 20 3.46 34749 D20UW1 34908 D20Rat2 34749 D20UW1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 727992 14532335 20 6935868 12079657 1 - by flanking markers 20 3660638 9534510 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 20 4855468 9899946 1 - by flanking markers 20 3621649 9243559 1 - by flanking markers 1300153 rat Bp171 Blood pressure QTL 171 1 3.37 41374 D1Rat265 37970 D1Rat210 37930 D1Rat183 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 Bp170 (interacts with);Bp172 (maps to same region);Bp173 (interacts with) 1 95453405 159388156 1 - by flanking markers 1 90448902 145865373 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 94364073 153076991 1 - by flanking markers 1 90664883 143200202 1 - by flanking markers 1300154 rat Bp189 Blood pressure QTL 189 14 3.04 34965 D14Rat10 40852 D14Rat90 36287 D14Rat12 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 14 32957485 73407773 1 - by flanking markers 14 33157432 73956701 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 33163316 73391571 1 - by flanking markers 14 30883777 68757901 1 - by flanking markers 1300155 rat Bp174 Blood pressure QTL 174 2 4.09 37018 D2Rat14 41400 D2Rat216 40672 D2Rat202 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) abnormal urine homeostasis;increased systemic arterial blood pressure hypertension;proteinuria 727992 14532335 Bp175 (maps to same region) 2 61825950 79917090 2 - by one flank and peak markers 2 29321080 74321080 5 - by peak with adj size 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 42776916 62238534 2 - by one flank and peak markers 2 42804607 60653831 2 - by one flank and peak markers 1300156 rat Bp179 Blood pressure QTL 179 4 2.85 35847 D4Rat12 34238 D4Mgh2 38908 D4Rat126 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 Bp178 (maps to same region) 4 36467227 37552486 1 - by flanking markers 4 15744638 36612108 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 36615599 37703537 1 - by flanking markers 4 38465774 39524530 1 - by flanking markers 1300157 rat Rf21 Renal function QTL 21 12 4.4 35501 D12Rat2 37830 D12Rat36 34729 D12Mgh5 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) decreased renal plasma flow rate hypertension;kidney disease 727992 14532335 12 13827920 39392915 1 - by flanking markers 12 9628802 33216334 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 11764995 37522089 1 - by flanking markers 12 9318216 32103380 1 - by flanking markers 1300158 rat Bp173 Blood pressure QTL 173 1 3.48 35166 D1Rat33 37556 D1Rat130 38878 D1Rat139 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Bp170 (interacts with);Bp171 (interacts with);Bp172 (interacts with) 1 123747670 208178693 1 - by flanking markers 1 115946374 189900838 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 122614824 201146953 1 - by flanking markers 1 115540693 185145286 1 - by flanking markers 1300159 rat Kidm4 Kidney mass QTL 4 3 3.83 36717 D3Rat17 40676 D3Rat142 36584 D3Rat6 kidney mass (VT:0002707) right kidney wet weight to body weight ratio (CMO:0001953) abnormal kidney size;abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 Rf10 (interacts with);Rf12 (interacts with) 3 133062559 171495734 1 - by flanking markers 3 121618954 159769019 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 126575595 165355668 1 - by flanking markers 3 121056165 157309487 1 - by flanking markers 1300160 rat Hrtrt3 Heart rate QTL 3 2 3.62 40242 D2Rat194 40672 D2Rat202 37018 D2Rat14 heart pumping trait (VT:2000009) absolute change in heart rate (CMO:0000534) abnormal heart rate;increased heart rate;increased systemic arterial blood pressure heart disease;hypertension 727992 14532335 2 47825961 70871600 1 - by flanking markers 2 29237360 51821161 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 28727867 52507805 1 - by flanking markers 2 29971593 51729300 1 - by flanking markers 1300161 rat Rf10 Renal function QTL 10 3 3.57 41322 D3Rat137 38456 D3Rat77 36745 D3Rat1 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 Kidm4 (interacts with);Rf11 (interacts with);Rf12 (interacts with) 3 176504241 183740530 2 - by one flank and peak markers 3 163335007 171063335 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 170428815 177699992 2 - by one flank and peak markers 3 161192952 169034231 2 - by one flank and peak markers 1300162 rat Bp188 Blood pressure QTL 188 12 3.19 37830 D12Rat36 35431 D12Rat22 35431 D12Rat22 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 727992 14532335 12 39392710 53694105 1 - by flanking markers 12 33216127 46043557 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 37521884 51955754 1 - by flanking markers 12 32103174 45899022 1 - by flanking markers 1300163 rat Cardf1 Cardiac cell morphology QTL 1 13 4.18 36922 D13Rat4 38240 D13Rat91 36922 D13Rat4 aorta morphology trait (VT:0000272) artery lesion measurement (CMO:0000975) abnormal aorta morphology aortic disease 727992;70849 14532335;11721057 13 19680631 55853202 1 - by flanking markers 13 1265159 46912163 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 14441582 50799665 1 - by flanking markers 13 11929449 45417941 1 - by flanking markers 1300164 rat Rf15 Renal function QTL 15 6 3.12 35963 D6Rat46 36586 D6Rat26 35653 D6Rat42 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 6 23080221 67112973 1 - by flanking markers 6 13286615 56714969 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 13122958 57516539 1 - by flanking markers 6 5074497 54641141 1 - by flanking markers 1300165 rat Rf9 Renal function QTL 9 2 3.28 37456 D2Rat147 34461 D2Mgh12 36213 D2Rat40 kidney glomerulus integrity trait (VT:0010546) index of glomerular damage (CMO:0001135) abnormal renal glomerulus morphology;increased systemic arterial blood pressure;kidney inflammation focal segmental glomerulosclerosis;hypertension 727992 14532335 2 158383046 235592880 1 - by flanking markers 2 138700979 210636169 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 138901276 217498710 1 - by flanking markers 2 133914684 202447032 1 - by flanking markers 1300166 rat Kidm6 Kidney mass QTL 6 13 3.93 37844 D13Rat85 33644 D13Mit4 33644 D13Mit4 kidney mass (VT:0002707) single kidney wet weight to body weight ratio (CMO:0000622) abnormal kidney weight kidney disease 727992 14532335 13 79488981 97381801 1 - by flanking markers 13 72141292 90551272 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 74568378 92916783 1 - by flanking markers 13 69060519 86800898 1 - by flanking markers 1300167 rat Hrtrt2 Heart rate QTL 2 1 4.35 36568 D1Rat4 34037 D1Mit1 38782 D1Rat136 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt1 (maps to same region) 1 12920106 76895298 2 - by one flank and peak markers 1 11859997 63434427 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 11314489 75844121 2 - by one flank and peak markers 1 11481312 75088344 2 - by one flank and peak markers 1300168 rat Bp170 Blood pressure QTL 170 1 2.76 40230 D1Rat295 40028 D1Rat301 35909 D1Rat74 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 Bp171 (interacts with);Bp172 (maps to same region);Bp173 (interacts with) 1 234174587 262883789 1 - by flanking markers 1 213554130 234595366 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 227107736 249206417 1 - by flanking markers 1 207702246 228581766 1 - by flanking markers 1300169 rat Bp177 Blood pressure QTL 177 3 2.96 38346 D3Rat98 39912 D3Rat180 41780 D3Rat227 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Bp176 (interacts with) 3 38636977 69467440 1 - by flanking markers 3 30253942 58764827 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 33477354 62922975 1 - by flanking markers 3 33703347 61017857 1 - by flanking markers 1300170 rat Rf6 Renal function QTL 6 1 3.14 37610 D1Rat167 36568 D1Rat4 37610 D1Rat167 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased renal plasma flow rate kidney disease 727992 14532335 Rf8 (interacts with) 1 5511572 12920275 1 - by flanking markers 1 4404877 11860328 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 3839159 11314658 1 - by flanking markers 1 4162807 11481482 1 - by flanking markers 1300171 rat Bp184 Blood pressure QTL 184 8 3.66 38670 D8Rat114 36327 D8Rat2 34180 D8Mgh1 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 8 80428299 126404948 1 - by flanking markers 8 74281610 123415406 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 76103982 127182642 1 - by flanking markers 8 70513503 118219066 1 - by flanking markers 1300172 rat Bp172 Blood pressure QTL 172 1 3.56 37598 D1Rat176 41374 D1Rat265 34037 D1Mit1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 Bp170 (maps to same region);Bp171 (maps to same region);Bp173 (interacts with) 1 36777313 95453561 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 35377508 94364229 1 - by flanking markers 1 32737273 90665040 1 - by flanking markers 1300173 rat Rf11 Renal function QTL 11 3 3.38 36717 D3Rat17 36584 D3Rat6 36797 D3Rat11 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 Rf10 (interacts with);Rf12 (maps to same region) 3 133062559 158307423 1 - by flanking markers 3 121618954 147990731 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 126575595 153412619 1 - by flanking markers 3 121056165 145956249 1 - by flanking markers 1300174 rat Bw15 Body weight QTL 15 12 2.93 40394 D12Rat89 35501 D12Rat2 40394 D12Rat89 body mass (VT:0001259) body weight loss (CMO:0001399) abnormal body weight 727992;2312611 14532335;19697080 Bw88 (maps to same region) 12 3966881 13828088 1 - by flanking markers 12 2957061 9628971 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 1 11765163 4 - by one flank marker only 12 1 9318387 4 - by one flank marker only 1300175 rat Cm5 Cardiac mass QTL 5 12 3.78 34729 D12Mgh5 35431 D12Rat22 37830 D12Rat36 heart mass (VT:0007028) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart size;abnormal renal plasma flow rate;increased systemic arterial blood pressure Cardiomegaly 727992 14532335 12 33647399 53694105 1 - by flanking markers 12 29130180 46043557 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 31723565 51955754 1 - by flanking markers 12 28064433 45899022 1 - by flanking markers 1300176 rat Hrtrt10 Heart rate QTL 10 7 3.19 35382 D7Rat36 34880 D7Rat31 35382 D7Rat36 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased systemic arterial blood pressure hypertension 727992 14532335 7 2632014 32338830 1 - by flanking markers 7 1526177 28488710 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 2653138 32258115 1 - by flanking markers 7 664270 26029351 1 - by flanking markers 1300177 rat Cm2 Cardiac mass QTL 2 8 3.65 41122 D8Rat159 36003 D8Rat14 36809 D8Rat23 heart mass (VT:0007028) heart weight (CMO:0000017) abnormal heart rate;abnormal heart size;increased systemic arterial blood pressure Cardiomegaly;hypertension 727992 14532335 8 58965714 107492076 2 - by one flank and peak markers 8 58135371 104697495 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 59234112 108068306 2 - by one flank and peak markers 8 54259986 100382532 2 - by one flank and peak markers 1300178 rat Hrtrt4 Heart rate QTL 4 3 3.74 41780 D3Rat227 40016 D3Rat168 39912 D3Rat180 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 3 50522686 101095668 1 - by flanking markers 3 41054012 89859652 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 45406058 94467785 1 - by flanking markers 3 43827364 90905114 1 - by flanking markers 1300179 rat Kidm5 Kidney mass QTL 5 7 3.51 42215 D7Arb16 35559 D7Rat13 40966 D7Rat133 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight kidney disease 727992 14532335 7 51264830 126904662 1 - by flanking markers 7 47145687 124315164 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 51251919 145729302 2 - by one flank and peak markers 7 43747012 135012528 2 - by one flank and peak markers 1300180 rat Bw14 Body weight QTL 14 9 3.776 40738 D9Rat130 34815 D9Rat16 35819 D9Rat26 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 727992 14532335 9 26333329 66570294 1 - by flanking markers 9 20102034 58516896 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 9 27486036 66757620 1 - by flanking markers 9 23754024 61381613 1 - by flanking markers 1302404 rat Cia27 Collagen induced arthritis QTL 27 10 2.6 0.0045 10642 D10Mit12 34128 D10Mgh1 44839 D10Wox7 joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint inflammation;joint swelling Experimental Arthritis 1302414;61063;1600534;2307198;2306769 9870869;16691185;18540828;19299744 Ean3 (maps to same region) 10 94240320 109962316 2 - by one flank and peak markers 10 95695048 110718848 2 - by one flank and peak markers 1302416 ACI.DA-(D10Rat2-D10Rat19)/Arb 10 79927661 112626471 5 - by peak with adj size 10 76452683 107211142 5 - by peak with adj size 1302786 rat Kidm8 Kidney mass QTL 8 5 28.15 33678 D5Mit10 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) enlarged kidney;increased blood urea nitrogen level polycystic kidney disease;uremia 629573 9097967 3334 Anks6 dominant 5 38938687 83938687 5 - by peak with adj size 5 35474610 80474610 5 - by peak with adj size 68118 728168 PKD WOK 5 34402409 79402409 5 - by peak with adj size 5 33215665 78215665 5 - by peak with adj size 1302787 rat Stl25 Serum triglyceride level QTL 25 1 2.7 0.0073 36592 D1Rat64 36757 D1Rat71 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating cholesterol level;increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 1 204172176 237556978 1 - by flanking markers 1 184857716 216663271 1 - by flanking markers intercross 60999 1302795 LEW HTG 1 197187728 230420772 1 - by flanking markers 1 180359209 210702199 1 - by flanking markers 1302788 rat Scl19 Serum cholesterol QTL 19 1 4.6 0.001 38792 D1Rat137 36432 D1Rat35 36765 D1Rat27 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 1299960 14709677 1 95325941 131959064 1 - by flanking markers 1 90306033 124749065 1 - by flanking markers intercross 60999 1302795 LEW HTG 1 94225372 130917265 1 - by flanking markers 1 90532338 123479925 1 - by flanking markers 1302789 rat Stl26 Serum triglyceride level QTL 26 2 3.1 0.0035 35693 D2Rat55 37424 D2Rat111 35915 D2Rat61 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 2 1 237043265 2 - by one flank and peak markers 2 212168913 242131387 2 - by one flank and peak markers intercross 60999 1302795 LEW HTG 2 218957047 240977220 1 - by flanking markers 1302790 rat Scl20 Serum cholesterol level QTL 20 5 6.4 1.0E-4 41318 D5Rat147 36237 D5Rat49 38338 D5Rat108 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) decreased circulating cholesterol level 1299960;2312642 14709677;19584880 Scl64 (maps to same region) 5 89056339 176978545 1 - by flanking markers 5 86116638 172913795 1 - by flanking markers intercross 60999 1302795 LEW HTG 5 84963058 173504662 1 - by flanking markers 5 82394392 166664054 1 - by flanking markers 1302791 rat Stl29 Serum triglyceride level QTL 29 13 3.3 0.0011 45079 D13Wox8 33644 D13Mit4 37088 D13Rat34 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level;increased circulating triglyceride level Hypercholesterolemia;Hypertriglyceridemia;Metabolic Syndrome 1299960 14709677 13 95174535 97381801 1 - by flanking markers 13 88260176 90551272 1 - by flanking markers 60999 1302795 LEW HTG 13 90652874 92916783 1 - by flanking markers 13 84730788 86800898 1 - by flanking markers 1302792 rat Scl21 Serum cholesterol level QTL 21 12 3.8 0.0011 35923 D12Rat12 38952 D12Rat40 34898 D12Rat20 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) decreased circulating cholesterol level 1299960 14709677 12 10898188 54450796 2 - by one flank and peak markers 12 7754826 25802539 1 - by flanking markers 60999 1302795 LEW HTG 12 8954593 27911196 1 - by flanking markers 12 7196730 46669029 2 - by one flank and peak markers 1302793 rat Bw16 Body weight QTL 16 2 5.0 1.0E-4 34461 D2Mgh12 36213 D2Rat40 34234 D2Mgh9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 2 189197988 235592715 1 - by flanking markers 2 163154358 210636008 1 - by flanking markers intercross 60999 1302795 LEW HTG 2 169852800 217498545 1 - by flanking markers 2 157142209 202446871 1 - by flanking markers 1302794 rat Stl27 Serum triglyceride level QTL 27 2 4.4 1.0E-4 38576 D2Rat182 34005 D2Mit8 39512 D2Rat210 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 2 43009380 169047413 1 - by flanking markers 2 24474447 148790758 1 - by flanking markers intercross 60999 1302795 LEW HTG 2 23837491 149614623 1 - by flanking markers 2 25413423 143657569 1 - by flanking markers 1331720 rat Rf43 Renal function QTL 43 17 2.881 34276 D17Mgh2 35302 D17Rat9 38348 D17Rat59 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) increased renal vascular resistance kidney disease;renal hypertension 70849 11721057 Hrtrt15 (maps to same region) 17 17801320 24686091 1 - by flanking markers 17 21286331 28903238 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 15743755 22711729 1 - by flanking markers 17 15330613 23017269 1 - by flanking markers 1331721 rat Bp210 Blood pressure QTL 210 5 3.413 34443 D5Mgh8 35823 D5Rat50 41492 D5Rat178 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased heart rate;increased systemic arterial blood pressure heart disease;hypertension 70849 11721057 5 152731895 177161806 1 - by flanking markers 5 149757277 173096209 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 149029982 173687766 1 - by flanking markers 5 143069996 166846814 1 - by flanking markers 1331722 rat Thshl1 Thyroid stimulating hormone level QTL 1 6 11.7 1.0E-4 35659 D6Rat18 40144 D6Rat119 38634 D6Rat103 blood thyroid-stimulating hormone amount (VT:0005119) serum thyroid stimulating hormone level (CMO:0001248) increased circulating thyroid-stimulating hormone level thyroid gland disease 1302891;10053640 15514085;21029000 3911;68418;68420 Tshr;Dio2;Dio3 Srcrt6 (maps to same region) 6 103168026 120420482 1 - by flanking markers 6 93373975 111239430 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 6 93706176 111134673 1 - by flanking markers 6 89762877 106752806 1 - by flanking markers 1331723 rat Bw25 Body weight QTL 25 7 3.348 35841 D7Rat19 33969 D7Mit4 40784 D7Rat135 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 70849 11721057 Kidm9 (maps to same region) 7 102486192 104437717 1 - by flanking markers 7 98568413 100273797 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 101918330 103867802 1 - by flanking markers 7 93242123 94811326 1 - by flanking markers 1331724 rat Bp223 Blood pressure QTL 223 15 3.53715 34222 D15Mgh8 34160 D15Mgh5 34409 D15Mgh9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849 11721057 Rf42 (maps to same region) 15 84794264 106602195 1 - by flanking markers 15 80361961 102741337 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 81255292 103165069 1 - by flanking markers 15 73690518 95018228 1 - by flanking markers 1331725 rat Bp212 Blood pressure QTL 212 6 3.52475 33987 D6Mit8 33889 D6Mit16 40438 D6Rat163 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp211 (maps to same region);Bp213 (maps to same region) 6 107370981 143011457 1 - by flanking markers 6 97561873 134379784 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 97949772 133849286 1 - by flanking markers 6 93701310 128713626 1 - by flanking markers 1331726 rat Bp208 Blood pressure QTL 208 3 3.129 33810 D3Mit2 34178 D3Mgh23 34304 D3Mgh18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased renal plasma flow rate;increased systemic arterial blood pressure hypertension;kidney disease 70849 11721057 Bp207 (maps to same region) 3 154751509 177528867 1 - by flanking markers 3 143214619 164269487 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 148348517 171467264 1 - by flanking markers 3 141339013 162184794 1 - by flanking markers 1331727 rat Bp237 Blood pressure QTL 237 18 3.053 10689 D18Mit5 34043 D18Mit16 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp238 (maps to same region) 18 32348154 63072413 1 - by flanking markers 18 32458819 64900201 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 63897621 1 - by flanking markers 18 31359408 61698465 1 - by flanking markers 1331728 rat Bp214 Blood pressure QTL 214 7 2.825 33648 D7Mit5 33729 D7Mit10 40784 D7Rat135 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp215 (maps to same region);Bp216 (maps to same region) 7 88393619 134514043 2 - by one flank and peak markers 7 85089895 130953311 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 88365265 134673427 2 - by one flank and peak markers 7 80221299 124373579 2 - by one flank and peak markers 1331729 rat Rf42 Renal function QTL 42 15 3.071 33713 D15Mit3 34222 D15Mgh8 34619 D15Mgh11 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) decreased renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 70849 11721057 Bp223 (maps to same region) 15 22070681 84794402 1 - by flanking markers 15 19348148 80362100 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 18093208 81255430 1 - by flanking markers 15 17362897 73690657 1 - by flanking markers 1331730 rat Scl27 Serum cholesterol level QTL 27 18 3.826 37738 D18Rat57 33884 D18Mit8 33884 D18Mit8 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating HDL cholesterol level familial hyperlipidemia 70849 11721057 Rf44 (maps to same region);Scl28 (maps to same region) 18 53100479 61177004 1 - by flanking markers 18 54605732 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 53861252 61985812 1 - by flanking markers 18 52292875 59796643 1 - by flanking markers 1331731 rat Bp216 Blood pressure QTL 216 7 2.851 40784 D7Rat135 33780 D7Mit1 33729 D7Mit10 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp214 (maps to same region);Bp215 (maps to same region) 7 111453751 141760897 1 - by flanking markers 7 108021523 141116504 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 111519266 143965591 1 - by flanking markers 7 102297359 133492884 1 - by flanking markers 1331732 rat Srn4 Serum renin concentration QTL 4 1 4.467 34037 D1Mit1 10337 D1Mgh5 33931 D1Mit10 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) increased circulating renin level kidney disease 70849 11721057 Rf27 (maps to same region);Rf28 (maps to same region);Rf29 (maps to same region) 1 36630109 80946315 2 - by one flank and peak markers 1 33134446 78134446 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 36033165 79689689 2 - by one flank and peak markers 1 35239598 78430678 2 - by one flank and peak markers 1331733 rat Bp233 Blood pressure QTL 233 18 3.97196 34550 D18Mgh9 36123 D18Rat9 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 25675732 71374137 1 - by flanking markers 18 25620884 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 25961026 81761656 2 - by one flank and peak markers 18 24796977 79788953 2 - by one flank and peak markers 1331734 rat Bp204 Blood pressure QTL 204 2 3.61192 10582 D2Mit12 35064 D2Rat64 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 201404917 258546510 1 - by flanking markers 2 174730375 232307864 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 181990297 240020001 1 - by flanking markers 2 168358098 223265385 1 - by flanking markers 1331735 rat Rf44 Renal function QTL 44 18 2.981 34092 D18Mgh8 10689 D18Mit5 34550 D18Mgh9 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 70849 11721057 Scl27 (maps to same region);Scl28 (maps to same region) 18 19003327 32348275 2 - by one flank and peak markers 18 15852436 32458940 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 19251717 32670473 2 - by one flank and peak markers 18 18234564 31359530 2 - by one flank and peak markers 1331736 rat Bp227 Blood pressure QTL 227 18 2.791 36914 D18Rat18 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 47463943 61177004 1 - by flanking markers 18 48759354 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 48248877 61985812 1 - by flanking markers 18 46718763 59796643 1 - by flanking markers 1331737 rat Uae29 Urinary albumin excretion QTL 29 19 5.5 41262 D19Rat57 40904 D19Rat86 35881 D19Rat11 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) increased urine protein level Albuminuria;proteinuria 1300043 15161966 19 17616412 70892142 2 - by one flank and peak markers 19 5975093 57235101 2 - by one flank and peak markers 631695 631696 SS/JrRkb SHR/FubRkb 19 6506761 60220581 2 - by one flank and peak markers 19 4096155 55283277 2 - by one flank and peak markers 1331738 rat Bp209 Blood pressure QTL 209 4 2.979 34174 D4Mgh7 34477 D4Mgh12 34477 D4Mgh12 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Hrtrt13 (maps to same region) 4 200825021 244849512 1 - by flanking markers 4 161454762 187126005 5 - by peak with adj size 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 136351734 180689124 1 - by flanking markers 4 138503169 179293946 1 - by flanking markers 1331739 rat Hrtrt14 Heart rate QTL 14 12 3.56232 35501 D12Rat2 34031 D12Mit7 37478 D12Rat43 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate;increased heart rate variability cardiovascular system disease;hypertension 70849 11721057 Bp218 (maps to same region);Bp219 (maps to same region);Rf41 (maps to same region);Wbc2 (maps to same region) 12 13827920 16511686 2 - by one flank and peak markers 12 9628802 17773949 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 11764995 14489679 2 - by one flank and peak markers 12 9318216 12829686 2 - by one flank and peak markers 1331740 rat Bw26 Body weight QTL 26 14 3.028 36536 D14Rat1 38932 D14Rat36 10135 D14Wox11 body mass (VT:0001259) body weight (CMO:0000012) heart left ventricle hypertrophy;increased body weight;increased systemic arterial diastolic blood pressure heart disease;hypertension;obesity 70849 11721057 14 4830815 32833594 1 - by flanking markers 14 4895894 33040140 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 4833233 33040042 1 - by flanking markers 14 3813074 30767156 1 - by flanking markers 1331741 rat Bp232 Blood pressure QTL 232 18 3.59112 34340 D18Mgh7 37104 D18Rat1 37738 D18Rat57 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 20092556 86108580 2 - by one flank and peak markers 18 22353754 86857890 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 22603736 87074531 1 - by flanking markers 18 21372893 83213037 2 - by one flank and peak markers 1331742 rat Bp228 Blood pressure QTL 228 18 3.88752 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331743 rat Uae28 Urinary albumin excretion QTL 28 6 4.5 35911 D6Rat33 38006 D6Rat69 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 1300043 15161966 6 1 51646896 2 - by one flank and peak markers 6 1 28765971 5 - by peak with adj size 631695 631696 SS/JrRkb SHR/FubRkb 6 1 41917988 2 - by one flank and peak markers 6 1 34235784 5 - by peak with adj size 1331744 rat Bp217 Blood pressure QTL 217 8 3.398 33559 D8Mit5 33957 D8Mit16 33858 D8Mit4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure;increased urine protein level hypertension;proteinuria 70849 11721057 Cm30 (maps to same region) 8 33603024 62633993 1 - by flanking markers 8 32203394 61853629 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 33558660 62857995 1 - by flanking markers 8 30848154 58482492 1 - by flanking markers 1331745 rat Bp203 Blood pressure QTL 203 2 4.377 33727 D2Mit14 34495 D2Mgh29 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 74641110 224018348 1 - by flanking markers 2 197256223 227310008 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 204585642 235290110 1 - by flanking markers 2 189599258 218414891 1 - by flanking markers 1331746 rat Kidm9 Kidney mass QTL 9 7 3.934 33648 D7Mit5 33755 D7Mit13 33557 D7Mit14 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) enlarged kidney kidney disease 70849 11721057 Bw25 (maps to same region);Kidm10 (maps to same region) 7 88393619 121978492 1 - by flanking markers 7 85089895 119050197 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 88365265 121986709 1 - by flanking markers 7 80221299 112308525 1 - by flanking markers 1331747 rat Hrtrt16 Heart rate QTL 16 20 3.163 34290 D18Mgh4 33997 D20Mit1 33997 D20Mit1 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 70849 11721057 20 28346715 57791882 5 - by peak with adj size 20 25673311 55268282 5 - by peak with adj size 10008 61499 BN/SsNHsd SS/JrHsdMcwi 20 26712323 56205956 5 - by peak with adj size 20 25209734 54435887 5 - by peak with adj size 1331748 rat Bp215 Blood pressure QTL 215 7 4.043 33755 D7Mit13 33780 D7Mit1 33729 D7Mit10 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp214 (maps to same region);Bp216 (maps to same region) 7 121978222 141760897 1 - by flanking markers 7 119049926 141116504 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 121986439 143965591 1 - by flanking markers 7 112308254 133492884 1 - by flanking markers 1331749 rat Hrtrt11 Heart rate QTL 11 1 2.973 11439 D1Mit30 33878 D1Mit27 34381 D1Mgh7 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 70849 11721057 Bp199 (maps to same region);Bp200 (maps to same region);Bp201 (maps to same region) 1 101048742 223075141 1 - by flanking markers 1 94473940 203303100 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 216213510 1 - by flanking markers 1 94494440 198211706 1 - by flanking markers 1331750 rat Bp220 Blood pressure QTL 220 13 2.98 34351 D13Mgh4 34483 D13Mgh9 11376 D13Mgh18 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849;1298024 11721057;11071381 BP19_H (maps to syntenic region);Bp221 (maps to same region) 13 47416073 92416073 4 - by one flank marker only 13 38489801 83489801 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 42310744 87310744 4 - by one flank marker only 13 37415584 82415584 4 - by one flank marker only 1331751 rat Bp199 Blood pressure QTL 199 1 3.60022 11439 D1Mit30 10951 D1Mit13 33959 D1Mit3 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp200 (maps to same region);Bp201 (maps to same region);Hrtrt11 (maps to same region) 1 101048742 205649793 1 - by flanking markers 1 94473940 186472032 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 198656062 1 - by flanking markers 1 94494440 181830018 1 - by flanking markers 1331752 rat Bw27 Body weight QTL 27 18 2.963 37738 D18Rat57 34182 D18Mgh3 33884 D18Mit8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 70849 11721057 Scl28 (maps to same region) 18 53100479 66665205 1 - by flanking markers 18 54605732 69013448 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 53861252 67502266 1 - by flanking markers 18 52292875 65845095 1 - by flanking markers 1331753 rat Bp231 Blood pressure QTL 231 18 3.643 11461 D18Mit1 37738 D18Rat57 33606 D18Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 15314027 53100658 1 - by flanking markers 18 12406975 54605912 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 15539427 53861431 1 - by flanking markers 18 11944299 52293055 1 - by flanking markers 1331754 rat Bp230 Blood pressure QTL 230 18 4.61609 34092 D18Mgh8 36123 D18Rat9 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 34826999 71374137 2 - by one flank and peak markers 18 15852436 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 31361341 76361341 5 - by peak with adj size 18 29792965 74792965 5 - by peak with adj size 1331755 rat Bp219 Blood pressure QTL 219 12 3.041 37478 D12Rat43 34729 D12Mgh5 34031 D12Mit7 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp218 (maps to same region);Hrtrt14 (maps to same region);Kidm11 (maps to same region);Rf41 (maps to same region);Wbc2 (maps to same region) 12 15169677 33647522 1 - by flanking markers 12 11416955 29130304 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 13127211 31723688 1 - by flanking markers 12 11073825 28064557 1 - by flanking markers 1331756 rat Rf34 Renal function QTL 34 5 4.16275 34226 D5Mgh1 33981 D5Mit4 34212 D5Mgh5 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) decreased renal plasma flow rate kidney disease 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 742398 97315322 2 - by one flank and peak markers 5 1 94516069 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 1 93273395 2 - by one flank and peak markers 5 1 90450412 2 - by one flank and peak markers 1331757 rat Cdexp1 CD45RC expression in CD8 T cells QTL 1 9 4.3 17.5 631290 D9Wox24 44552 D9Wox21 60669 D9Got8 CD8-positive T cell quantity (VT:0008077) blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990) abnormal CD8-positive, alpha beta T cell morphology autoimmune disease 1302824 15322174 recessive 9 1 9858600 2 - by one flank and peak markers 9 1 26311568 5 - by peak with adj size 631593 631594 LEW/Rj BN/Rj 9 10869391 15509311 1 - by flanking markers 9 1024537 67509080 1 - by flanking markers 1331758 rat Bp207 Blood pressure QTL 207 3 2.848 33838 D3Mit18 33927 D3Mit3 33808 D3Mit4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp208 (maps to same region) 3 123827331 148388048 1 - by flanking markers 3 112334733 136402080 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 117303473 141971336 1 - by flanking markers 3 112287552 135181505 1 - by flanking markers 1331759 rat Hrtrt13 Heart rate QTL 13 4 3.54628 33991 D4Mit28 33832 D4Mit27 11377 D4Mit1 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate;increased heart rate variability cardiovascular system disease;hypertension 70849 11721057 Bp209 (maps to same region) 4 173580126 233483643 1 - by flanking markers 4 111754988 172369380 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 108876717 169215811 1 - by flanking markers 4 110275411 168266883 1 - by flanking markers 1331760 rat Bp206 Blood pressure QTL 206 2 3.62454 34334 D2Mgh21 34461 D2Mgh12 10387 D2Mgh26 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 75985115 235592880 1 - by flanking markers 2 56214854 210636169 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 56244671 217498710 1 - by flanking markers 2 56043031 202447032 1 - by flanking markers 1331761 rat Bp218 Blood pressure QTL 218 12 2.973 37478 D12Rat43 34455 D12Mgh8 34729 D12Mgh5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp219 (maps to same region);Hrtrt14 (maps to same region);Rf41 (maps to same region);Wbc2 (maps to same region) 12 15169677 52125243 2 - by one flank and peak markers 12 11416955 46782294 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 13127211 50320041 2 - by one flank and peak markers 12 11073825 45055165 2 - by one flank and peak markers 1331762 rat Rf40 Renal function QTL 40 10 3.873 34359 D10Mgh11 34648 D10Mgh14 34359 D10Mgh11 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) increased renal vascular resistance kidney disease;renal hypertension 70849 11721057 10 23722820 65109346 1 - by flanking markers 10 29974190 65379965 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 23861015 66539843 1 - by flanking markers 10 29299504 64155584 1 - by flanking markers 1331763 rat Wbc2 White blood cell count QTL 2 12 3.162 34246 D12Mgh3 34455 D12Mgh8 34729 D12Mgh5 leukocyte quantity (VT:0000217) total white blood cell count (CMO:0000365) increased leukocyte cell number Inflammation;heart disease 70849 11721057 Bp218 (maps to same region);Bp219 (maps to same region);Hrtrt14 (maps to same region) 12 29257552 38037368 2 - by one flank and peak markers 12 25271823 32988661 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 27285473 36161779 2 - by one flank and peak markers 12 24234777 31894213 2 - by one flank and peak markers 1331764 rat Bp205 Blood pressure QTL 205 2 3.476 36145 D2Rat73 34278 D2Mgh14 34425 D2Mgh1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 45399390 62179292 1 - by flanking markers 2 26101088 42866342 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 26267995 43133606 1 - by flanking markers 2 26999571 43154682 1 - by flanking markers 1331765 rat Hrtrt15 Heart rate QTL 15 17 4.094 34276 D17Mgh2 36329 D17Rat32 35302 D17Rat9 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate;increased heart rate variability cardiovascular system disease;hypertension 70849 11721057 Rf43 (maps to same region) 17 17801320 62813877 1 - by flanking markers 17 21286331 36519723 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 15743755 61036897 1 - by flanking markers 17 15330613 55836425 1 - by flanking markers 1331766 rat Bp236 Blood pressure QTL 236 18 3.022 11461 D18Mit1 10689 D18Mit5 34340 D18Mgh7 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 15314027 32348275 1 - by flanking markers 18 12406975 32458940 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 15539427 32670473 1 - by flanking markers 18 11944299 31359530 1 - by flanking markers 1331767 rat Hrtrt12 Heart rate QTL 12 2 3.373 34495 D2Mgh29 34505 D2Mgh16 33763 D2Mit15 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region) 2 74640967 275789260 1 - by flanking markers 2 227309864 250463890 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 235289967 257110527 1 - by flanking markers 2 218414747 240841241 1 - by flanking markers 1331768 rat Kidm10 Kidney mass QTL 10 7 4.62096 33648 D7Mit5 33729 D7Mit10 33557 D7Mit14 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) enlarged kidney kidney disease 70849 11721057 Kidm9 (maps to same region) 7 88393619 143398775 2 - by one flank and peak markers 7 85089895 140651095 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 88365265 133365265 4 - by one flank marker only 7 80221299 125221299 4 - by one flank marker only 1331769 rat Rf39 Renal function QTL 39 8 3.871 33858 D8Mit4 11225 D8Mgh15 33957 D8Mit16 urine output (VT:0003620) timed urine volume (CMO:0000260) polyuria kidney disease 70849 11721057 Cm30 (maps to same region) 8 44187546 105956241 1 - by flanking markers 8 44484215 103672447 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 45712344 80003418 2 - by one flank and peak markers 8 41866876 75097878 2 - by one flank and peak markers 1331770 rat Bp234 Blood pressure QTL 234 18 3.807 33884 D18Mit8 36123 D18Rat9 34182 D18Mgh3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 61176840 71374137 1 - by flanking markers 18 62228896 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 61985648 73018740 2 - by one flank and peak markers 18 59796478 71893566 2 - by one flank and peak markers 1331771 rat Rf35 Renal function QTL 35 5 4.36965 34226 D5Mgh1 36558 D5Rat19 34212 D5Mgh5 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) increased systemic arterial blood pressure hypertension 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf34 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 4566363 93491357 2 - by one flank and peak markers 5 378448 90620456 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 1 89432042 2 - by one flank and peak markers 5 729470 86724018 2 - by one flank and peak markers 1331772 rat Cdexp2 CD45RC expression in CD8 T cells QTL 2 20 5.7 22.5 34749 D20UW1 37872 D20Rat31 37594 D20Rat41 CD8-positive T cell quantity (VT:0008077) blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990) abnormal CD8-positive, alpha beta T cell morphology autoimmune disease 1302824 15322174 additive 20 6935868 12972703 1 - by flanking markers 20 3660638 10410227 1 - by flanking markers 631593 631594 LEW/Rj BN/Rj 20 4855468 10800530 1 - by flanking markers 20 3621649 10078919 1 - by flanking markers 1331773 rat Scl26 Serum cholesterol level QTL 26 5 3.065 34212 D5Mgh5 36558 D5Rat19 34419 D5Mgh25 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level familial hyperlipidemia 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region) 5 49028773 93491357 1 - by flanking markers 5 45499364 90620456 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 44404276 89432042 1 - by flanking markers 5 43726656 86724018 1 - by flanking markers 1331774 rat Bp226 Blood pressure QTL 226 18 4.41065 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331775 rat Bp235 Blood pressure QTL 235 18 3.201 34092 D18Mgh8 10689 D18Mit5 34550 D18Mgh9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 19003327 32348275 2 - by one flank and peak markers 18 15852436 32458940 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 19251717 32670473 2 - by one flank and peak markers 18 18234564 31359530 2 - by one flank and peak markers 1331776 rat Bp225 Blood pressure QTL 225 18 2.829 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331777 rat Bw24 Body weight QTL 24 3 3.503 34336 D3Mgh7 35380 D3Rat27 34146 D3Mgh6 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 70849;2298688 11721057;18612083 Bw82 (maps to same region) 3 45609749 99297680 1 - by flanking markers 3 36556706 87981257 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 40523593 92654473 1 - by flanking markers 3 39454637 89115240 1 - by flanking markers 1331778 rat Rf28 Renal function QTL 28 1 4.66 34433 D1Mgh3 10337 D1Mgh5 33931 D1Mit10 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) increased urine potassium level kidney disease 70849 11721057 Rf27 (maps to same region);Rf29 (maps to same region);Srn4 (maps to same region) 1 47428369 80946315 1 - by flanking markers 1 40204051 78134446 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 46113461 79689689 1 - by flanking markers 1 45803140 78430678 1 - by flanking markers 1331779 rat Rf38 Renal function QTL 38 6 2.876 34138 D6Mgh8 11241 D6Mit3 34184 D6Mgh11 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;kidney failure hypertension 70849 11721057 Rf37 (maps to same region) 6 44763886 85163291 1 - by flanking markers 6 32764436 75049644 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 34995656 75623393 1 - by flanking markers 6 32074428 72227641 1 - by flanking markers 1331780 rat Bp238 Blood pressure QTL 238 18 3.269 36914 D18Rat18 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region) 18 47463943 61177004 1 - by flanking markers 18 48759354 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 48248877 61985812 1 - by flanking markers 18 46718763 59796643 1 - by flanking markers 1331781 rat Scl28 Serum cholesterol level QTL 28 18 3.995 11461 D18Mit1 34550 D18Mgh9 34340 D18Mgh7 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating cholesterol level Hypercholesterolemia 70849 11721057 Bw27 (maps to same region);Rf44 (maps to same region);Scl27 (maps to same region) 18 15314027 25675871 1 - by flanking markers 18 12406975 25621024 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 15539427 25961165 1 - by flanking markers 18 11944299 24797117 1 - by flanking markers 1331782 rat Rf36 Renal function QTL 36 5 3.296 40386 D5Rat131 39378 D5Rat149 33981 D5Mit4 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate hypertension 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Scl26 (maps to same region) 5 39377361 104771061 1 - by flanking markers 5 35390492 101506667 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 85800910 100745614 2 - by one flank and peak markers 5 83840598 97059958 2 - by one flank and peak markers 1331783 rat Bp221 Blood pressure QTL 221 13 3.72886 37844 D13Rat85 33644 D13Mit4 33644 D13Mit4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;increased systemic arterial diastolic blood pressure hypertension 70849;10755344 11721057;22912817 Bp220 (maps to same region);Bp222 (maps to same region);Bp387 (maps to same region) 13 79488981 97381801 1 - by flanking markers 13 72141292 90551272 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 74568378 92916783 1 - by flanking markers 13 69060519 86800898 1 - by flanking markers 1331784 rat Bp222 Blood pressure QTL 222 13 2.944 34076 D13Mgh1 33947 D13Mit9 34351 D13Mgh4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp221 (maps to same region) 13 26674672 63533335 1 - by flanking markers 13 7538626 55033994 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 21482481 58537177 1 - by flanking markers 13 17694436 53050594 1 - by flanking markers 1331785 rat Rf27 Renal function QTL 27 1 4.643 35885 D1Rat8 10337 D1Mgh5 34433 D1Mgh3 urine sodium amount (VT:0006274) urine sodium level (CMO:0000129) kidney disease;renal hypertension 70849 11721057 Rf28 (maps to same region);Rf29 (maps to same region);Srn4 (maps to same region) 1 32915602 80946315 1 - by flanking markers 1 29683182 78134446 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 31489454 79689689 1 - by flanking markers 1 28879780 78430678 1 - by flanking markers 1331786 rat Kidm11 Kidney mass QTL 11 12 3.571 37478 D12Rat43 34246 D12Mgh3 34031 D12Mit7 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) enlarged kidney;increased kidney weight hypertension 70849 11721057 Bp219 (maps to same region);Rf41 (maps to same region) 12 15169677 29257669 1 - by flanking markers 12 11416955 25271941 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 13127211 27285590 1 - by flanking markers 12 11073825 24234895 1 - by flanking markers 1331787 rat Rf41 Renal function QTL 41 12 2.998 34086 D12Mgh9 34729 D12Mgh5 34086 D12Mgh9 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate hypertension 70849 11721057 Bp218 (maps to same region);Bp219 (maps to same region);Hrtrt14 (maps to same region);Kidm11 (maps to same region) 12 33647522 47758580 1 - by flanking markers 12 29130304 41447755 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 31723688 45946802 1 - by flanking markers 12 28064557 40218380 1 - by flanking markers 1331788 rat Rf45 Renal function QTL 45 19 2.818 33917 D19Mit4 5001959 D19Mit14 33602 D19Mit10 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate hypertension 70849 11721057 19 28094796 63229168 2 - by one flank and peak markers 19 16770857 49024175 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 19 17028003 52538299 2 - by one flank and peak markers 19 15605023 46559041 2 - by one flank and peak markers 1331789 rat Rf37 Renal function QTL 37 6 3.224 11241 D6Mit3 40438 D6Rat163 33987 D6Mit8 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;abnormal urination pattern 70849 11721057 Rf38 (maps to same region) 6 85163175 129578985 2 - by one flank and peak markers 6 75049527 120074417 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 75623277 120276465 2 - by one flank and peak markers 6 72202632 115200186 2 - by one flank and peak markers 1331790 rat Bp201 Blood pressure QTL 201 1 3.127 33878 D1Mit27 34009 D1Mit34 33945 D1Mit18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp199 (maps to same region);Bp200 (maps to same region);Hrtrt11 (maps to same region) 1 223074949 252776464 1 - by flanking markers 1 203302907 230963799 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 216213318 245529710 1 - by flanking markers 1 198211513 225126682 1 - by flanking markers 1331791 rat Cm31 Cardiac mass QTL 31 10 3.84606 34359 D10Mgh11 10466 D10Mit1 34718 D10Mgh23 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight;increased systemic arterial blood pressure Cardiomegaly;hypertension 70849 11721057 10 23722820 93929812 1 - by flanking markers 10 29974190 95369088 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 23861015 112626471 2 - by one flank and peak markers 10 29299504 107211142 2 - by one flank and peak markers 1331792 rat Rf29 Renal function QTL 29 1 4.589 34037 D1Mit1 10337 D1Mgh5 33931 D1Mit10 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) increased urine potassium level kidney disease 70849 11721057 Rf27 (maps to same region);Rf28 (maps to same region);Srn4 (maps to same region) 1 36630109 80946315 2 - by one flank and peak markers 1 33134446 78134446 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 36033165 79689689 2 - by one flank and peak markers 1 35239598 78430678 2 - by one flank and peak markers 1331793 rat Bp200 Blood pressure QTL 200 1 3.71601 11439 D1Mit30 34399 D1Mgh9 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849 11721057 Bp199 (maps to same region);Bp201 (maps to same region);Hrtrt11 (maps to same region) 1 101048742 195235510 1 - by flanking markers 1 94473940 176855135 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 188289386 1 - by flanking markers 1 94494440 172949803 1 - by flanking markers 1331794 rat Bp202 Blood pressure QTL 202 2 3.66819 34114 D2Mgh15 35064 D2Rat64 34495 D2Mgh29 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849;10755344 11721057;22912817 Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Bp389 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 166536839 258546510 1 - by flanking markers 2 146228221 232307864 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 147122993 240020001 1 - by flanking markers 2 141194931 223265385 1 - by flanking markers 1331795 rat Rf30 Renal function QTL 30 3 3.708 34336 D3Mgh7 35380 D3Rat27 34146 D3Mgh6 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) abnormal urine homeostasis;abnormal urine osmolality hypertension 70849 11721057 3 45609749 99297680 1 - by flanking markers 3 36556706 87981257 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 40523593 92654473 1 - by flanking markers 3 39454637 89115240 1 - by flanking markers 1331796 rat Thshl2 Thyroid stimulating hormone level QTL 2 5 2.3 39378 D5Rat149 37864 D5Rat93 40262 D5Rat157 blood thyroid-stimulating hormone amount (VT:0005119) serum thyroid stimulating hormone level (CMO:0001248) increased circulating thyroid-stimulating hormone level thyroid gland disease 1302891;10053640 15514085;21029000 2504 Dio1 Scort26 (maps to same region) 5 104751414 157347193 1 - by flanking markers 5 101506332 154014139 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 5 100723739 153577831 1 - by flanking markers 5 97059760 147465714 1 - by flanking markers 1331797 rat Bp213 Blood pressure QTL 213 6 3.291 34126 D6Mgh4 33889 D6Mit16 39256 D6Rat78 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp211 (maps to same region);Bp212 (maps to same region) 6 117391806 143011457 1 - by flanking markers 6 108503674 134379784 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 108154445 133849286 1 - by flanking markers 6 104085867 128713626 1 - by flanking markers 1331798 rat Bp224 Blood pressure QTL 224 18 3.53873 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331799 rat Bp211 Blood pressure QTL 211 6 3.66407 11241 D6Mit3 39256 D6Rat78 40438 D6Rat163 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp212 (maps to same region);Bp213 (maps to same region) 6 85163175 145434939 1 - by flanking markers 6 75049527 136649854 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 75623277 136426962 1 - by flanking markers 6 72202632 130919985 1 - by flanking markers 1331800 rat Scl25 Serum cholesterol level QTL 25 1 3.013 11439 D1Mit30 34011 D1Mit2 34381 D1Mgh7 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 70849 11721057 1 101048742 128153174 2 - by one flank and peak markers 1 94473940 134980682 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 127203999 2 - by one flank and peak markers 1 94494440 117601394 2 - by one flank and peak markers 1331801 rat Rf33 Renal function QTL 33 5 4.149 34212 D5Mgh5 34583 D5Rjr1 10826 D5Mgh23 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;kidney failure hypertension 70849 11721057 Rf32 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 49028773 138293117 1 - by flanking markers 5 45499364 135916908 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 44404276 134502294 1 - by flanking markers 5 43726656 129132602 1 - by flanking markers 1331802 rat Srn5 Serum renin concentration QTL 5 4 3.045 36554 D4Rat47 11377 D4Mit1 34174 D4Mgh7 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) abnormal circulating renin level hypertension 70849 11721057 Rf31 (maps to same region) 4 178652560 224309034 2 - by one flank and peak markers 4 115896404 160896404 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 116726724 157291438 2 - by one flank and peak markers 4 119428175 157578333 2 - by one flank and peak markers 1331803 rat Rf32 Renal function QTL 32 5 2.798 34583 D5Rjr1 34443 D5Mgh8 34443 D5Mgh8 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;kidney failure hypertension 70849 11721057 Rf33 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 138292944 152732057 1 - by flanking markers 5 135900621 149757440 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 134502121 149030144 1 - by flanking markers 5 129132428 143070159 1 - by flanking markers 1331804 rat Cm30 Cardiac mass QTL 30 8 3.77443 35663 D8Rat51 11225 D8Mgh15 33913 D8Mit13 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased body weight;increased heart weight Cardiomegaly;obesity 70849 11721057 Bp217 (maps to same region);Rf39 (maps to same region) 8 30947236 105956241 1 - by flanking markers 8 29559446 103672447 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 30918112 58858224 2 - by one flank and peak markers 8 28242912 53961020 2 - by one flank and peak markers 1331805 rat Cm29 Cardiac mass QTL 29 2 3.50746 34114 D2Mgh15 35064 D2Rat64 34461 D2Mgh12 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight Cardiomegaly 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Hrtrt12 (maps to same region) 2 166536839 258546510 1 - by flanking markers 2 146228221 232307864 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 147122993 240020001 1 - by flanking markers 2 141194931 223265385 1 - by flanking markers 1331806 rat Bp229 Blood pressure QTL 229 18 4.36484 36914 D18Rat18 36123 D18Rat9 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 47463943 71374137 1 - by flanking markers 18 48759354 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 48248877 59473805 2 - by one flank and peak markers 18 46718763 57867167 2 - by one flank and peak markers 1331807 rat Rf31 Renal function QTL 31 4 2.988 34238 D4Mgh2 34230 D4Mgh24 33757 D4Mit2 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) abnormal urine homeostasis;abnormal urine osmolality hypertension 70849 11721057 Srn5 (maps to same region) 4 37552221 140028145 1 - by flanking markers 4 36611842 73752590 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 37703272 75345433 1 - by flanking markers 4 39524264 74726312 1 - by flanking markers 1331837 rat Bw23 Body weight QTL 23 8 4.19 7.0E-5 10178 D8Wox4 11223 D8Wox6 44494 D8Got144 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1300044 15164172 8 49155635 105948812 1 - by flanking markers 8 85328126 103665018 2 - by one flank and peak markers 10017 60985 GK/KyoSwe BN 8 50529563 106506973 1 - by flanking markers 8 46531722 99083736 1 - by flanking markers 1331838 rat Niddm61 Non-insulin dependent diabetes mellitus QTL 61 8 3.53 4.0E-4 10819 D8Got43 11223 D8Wox6 44445 D8Got99 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level;increased insulin secretion type 2 diabetes mellitus 1300044 15164172 8 39232847 105948812 1 - by flanking markers 8 38003289 103665018 1 - by flanking markers 10017 60985 GK/KyoSwe BN 8 39230130 106506973 1 - by flanking markers 8 36469535 99083736 1 - by flanking markers 1331839 rat Eae18b Experimental allergic encephalomyelitis QTL 18b 10 5.8 0.03 42921 D10Rat243 36916 D10Rat58 37170 D10Rat123 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) paralysis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 1302437;4145472 15240732;19865101 3644;3645;1586495 Ccl11;Ccl2;Ccl1 recessive 10 63463237 70966782 1 - by flanking markers 10 67774947 71067824 1 - by flanking markers Intercross 1331833 DA.ACI-(D10Rat15-D10Rat29) 10 64550912 70202084 1 - by flanking markers 10 61248303 67785171 1 - by flanking markers 1354580 rat Scort1 Serum corticosterone level QTL 1 1 3.4 36105 D1Rat51 34194 D1Mgh14 37184 D1Rat188 blood corticosterone amount (VT:0005345) blood corticosterone level (CMO:0001172) abnormal circulating corticosterone level hypertension 1302893 15452030 1 173583273 285604895 1 - by flanking markers 1 159782445 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 167394665 278228889 1 - by flanking markers 1 156677124 256448636 1 - by flanking markers 1354581 rat Bp247 Blood pressure QTL 247 17 4.5 38884 D17Rat94 35473 D17Rat58 38772 D17Rat102 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) abnormal systemic arterial blood pressure;increased pulse pressure hypertension 1302893 15452030 17 1 75089871 2 - by one flank and peak markers 17 1 81039660 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 1 73413148 2 - by one flank and peak markers 17 1 69599340 2 - by one flank and peak markers 1354582 rat Stl11 Serum triglyceride level QTL 11 7 3.42 35773 D7Rat8 34393 D7Mgh20 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 7 129105387 143501887 4 - by one flank marker only 7 126748283 143002779 4 - by one flank marker only 61014 70509 OLETF F344/NRrrc 7 129412003 145729302 4 - by one flank marker only 7 119513385 135012528 4 - by one flank marker only 1354583 rat Despr3 Despair related QTL3 5 4.98 2.0E-4 3.6 37112 D5Rat40 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 61105 61109 WKY/NHsd F344/NHsd 1354584 rat Despr6 Despair related QTL 6 16 3.1 0.0067 2.3 42022 D16Arb5 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 16 1 41109533 5 - by peak with adj size 16 1 40096603 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 16 1 41240937 5 - by peak with adj size 16 1 39533930 5 - by peak with adj size 1354585 rat Eae18a Experimental allergic encephalomyelitis QTL 18a 10 7.5 4.0E-4 11479 D10Mit8 1303359 D10Got166 1303357 D10Got165 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) paralysis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 1302437;2293859;2306769 15240732;16624898;19299744 additive Eae23 (sub_region);Ean3 (maps to same region) 10 55422036 60141913 1 - by flanking markers 10 55851702 60865280 1 - by flanking markers Intercross 1331824 DA.ACI-(D10Rat219-D10Rat29) 10 55678976 60404791 1 - by flanking markers 10 53797385 58445852 1 - by flanking markers 1354586 rat Despr1 Despair related QTL 1 2 4.88 0.0035 1.9 39914 D2Rat188 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894;1358767 15457344;15685431 Stresp13 (maps to same region) 1 122414658 167414658 5 - by peak with adj size 2 1 23400664 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1354587 rat Kidm21 Kidney mass QTL 21 10 3.3 41030 D10Rat183 36319 D10Rat26 40978 D10Rat168 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) abnormal kidney weight hypertension 1302893 15452030 10 15188449 62219555 2 - by one flank and peak markers 10 15274216 62791536 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 10 15375474 62469074 2 - by one flank and peak markers 10 15028513 60430477 2 - by one flank and peak markers 1354588 rat Bvd4 Brain ventricular dilatation QTL 4 17 5.31 0.001 38464 D17Rat79 39318 D17Rat65 10348 D17Mit4 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 17 54261257 88435496 1 - by flanking markers 17 62026925 93930006 1 - by flanking markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 17 56224296 86731080 1 - by flanking markers 17 53498828 82479847 1 - by flanking markers 1354589 rat Bw31 Body weight QTL 31 3 3.3 38346 D3Rat98 35086 D3Rat31 35947 D3Rat45 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893;2298688 15452030;18612083 Bw82 (maps to same region) 3 38636977 87839442 1 - by flanking markers 3 30253942 76620970 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 3 33477354 81136227 1 - by flanking markers 3 33703347 78196190 1 - by flanking markers 1354590 rat Despr11 Despair related QTL 11 3 3.1E-5 4.8 41162 D3Rat181 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894;2312611 15457344;19697080 Gluco46 (maps to same region) 3 36534996 81534996 5 - by peak with adj size 3 25754538 70754538 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 3 29908255 74908255 5 - by peak with adj size 3 28468571 73468571 5 - by peak with adj size 1354591 rat Cm36 Cardiac mass QTL 36 1 4.1 35220 D1Rat29 37184 D1Rat188 38564 D1Rat140 heart left ventricle mass (VT:0007031) calculated heart weight (CMO:0000073) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 1 110018554 226102807 1 - by flanking markers 1 103149923 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 219232156 1 - by flanking markers 1 102813953 201278233 1 - by flanking markers 1354592 rat Rf50 Renal function QTL 50 2 3.5 36902 D2Rat270 35643 D2Rat21 33765 D2Mit35 urine output (VT:0003620) timed urine volume (CMO:0000260) polyuria hypertension 1302893 15452030 2 73465326 95410202 1 - by flanking markers 2 53661468 75806439 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 54436698 75687607 1 - by flanking markers 2 53822747 74786777 1 - by flanking markers 1354593 rat Stl12 Serum triglyceride level QTL 12 11 3.36 34725 D11Mgh3 34118 D11Mgh2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 11 72739687 93518069 4 - by one flank marker only 11 68234781 87759784 4 - by one flank marker only 61014 70509 OLETF F344/NRrrc 11 69649708 90463843 4 - by one flank marker only 11 66422148 86241447 4 - by one flank marker only 1354594 rat Despr10 Despair related QTL 10 2 2.49E-6 7.8 41152 D2Rat220 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 2 139475534 184475534 5 - by peak with adj size 2 119504072 164504072 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 2 119789823 164789823 5 - by peak with adj size 2 114654253 159654253 5 - by peak with adj size 1354595 rat Despr4 Despair related QTL 4 8 2.16 0.0036 1.8 37742 D8Rat163 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 8 10411269 55411269 5 - by peak with adj size 8 9008612 54008612 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 8 10388439 55388439 5 - by peak with adj size 8 7688955 52688955 5 - by peak with adj size 1354596 rat Bw32 Body weight QTL 32 17 4.5 35176 D17Rat2 35585 D17Rat151 38884 D17Rat94 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893;2312611 15452030;19697080 Bw91 (maps to same region) 17 5553716 65440857 1 - by flanking markers 17 9988620 71570057 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 63676140 1 - by flanking markers 17 4299130 60781592 1 - by flanking markers 1354597 rat Kidm13 Kidney mass QTL 13 3 2.9 10678 D3Mgh21 40934 D3Rat165 42139 D3Arb8 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) abnormal kidney weight hypertension 1302893 15452030 3 48366676 115471051 1 - by flanking markers 3 39052756 103304908 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 3 43295930 108914061 1 - by flanking markers 3 41874578 104104347 1 - by flanking markers 1354598 rat Srn6 Serum renin concentration QTL 6 5 3.8 37440 D5Rat84 39478 D5Rat204 37944 D5Rat83 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal circulating renin level;decreased circulating renin level Metabolic Syndrome;cardiovascular system disease;kidney disease 1302893 15452030 5 75720253 160966475 1 - by flanking markers 5 71971592 157597184 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 5 71552569 157225114 1 - by flanking markers 5 69540295 151018848 1 - by flanking markers 1354599 rat Bw29 Body weight QTL 29 1 3.46 0.001 7.0 40798 D1Rat256 body mass (VT:0001259) body weight (CMO:0000012) weight loss Adrenal Insufficiency 1302889 15252022 1 35632458 80632458 5 - by peak with adj size 1 31371950 76371950 5 - by peak with adj size 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 1 34449112 79449112 5 - by peak with adj size 1 33449848 78449848 5 - by peak with adj size 1354600 rat Salc2 Saline consumption QTL 2 19 9.91 0.001 29.8 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 drinking behavior trait (VT:0001422) saline drink intake rate (CMO:0001627) abnormal drinking behavior Adrenal Insufficiency 1302889 15252022 3094 Nr3c2 19 42098191 52509704 1 - by flanking markers 19 25548711 39854409 2 - by one flank and peak markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 19 31194301 41686140 1 - by flanking markers 19 27530207 37947399 1 - by flanking markers 1354601 rat Slep1 Serum leptin concentration QTL 1 2 5.39 0.065 60793 D2Wox3 34234 D2Mgh9 33850 D2Mit30 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 737686 14724732 dominant 2 62195476 218191419 1 - by flanking markers 2 42882523 191378271 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 2 43149788 198704485 1 - by flanking markers 2 43171017 184114403 1 - by flanking markers 1354602 rat Bw35 Body weight QTL 35 1 12.2 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354603 rat Bp243 Blood pressure QTL 243 2 3.9 38976 D2Rat124 33765 D2Mit35 36902 D2Rat270 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) abnormal systemic arterial blood pressure;increased systemic arterial diastolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 2 45317613 155139446 1 - by flanking markers 2 1 131530924 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 2 26186097 135654963 1 - by flanking markers 2 26917817 127469484 1 - by flanking markers 1354604 rat Bw36 Body weight QTL 36 3 2.9 38346 D3Rat98 40934 D3Rat165 42139 D3Arb8 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893;2298688 15452030;18612083 Bw82 (maps to same region) 3 38636977 115471051 1 - by flanking markers 3 30253942 103304908 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 3 33477354 108914061 1 - by flanking markers 3 33703347 104104347 1 - by flanking markers 1354605 rat Rf48 Renal function QTL 48 2 2.9 35643 D2Rat21 38466 D2Rat118 41300 D2Rat221 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) abnormal circulating creatinine level hypertension 1302893 15452030 2 95410090 239931716 1 - by flanking markers 2 75806326 214989298 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 75687495 221880419 1 - by flanking markers 2 74786664 206665859 1 - by flanking markers 1354606 rat Bp246 Blood pressure QTL 246 1 3.6 35220 D1Rat29 33945 D1Mit18 40876 D1Rat278 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) abnormal systemic arterial blood pressure;increased pulse pressure hypertension 1302893 15452030 1 110018554 246119106 1 - by flanking markers 1 103149923 224426393 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 238830534 1 - by flanking markers 1 102813953 218753816 1 - by flanking markers 1354607 rat Gmadr1 Adrenal mass QTL 1 19 5.83 24.4 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) small adrenal glands Adrenal Insufficiency;adrenal gland disease 1302889 15252022 3094 Nr3c2 19 42098191 52509704 1 - by flanking markers 19 25548711 39854409 2 - by one flank and peak markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 19 31194301 41686140 1 - by flanking markers 19 27530207 37947399 1 - by flanking markers 1354608 rat Cm33 Cardiac mass QTL 33 10 2.8 36087 D10Rat156 34813 D10Rat16 36319 D10Rat26 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 10 56440444 96133217 1 - by flanking markers 10 56930545 97589703 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 10 56698730 101698730 4 - by one flank marker only 10 54809292 99809292 4 - by one flank marker only 1354609 rat Niddm62 Non-insulin dependent diabetes mellitus QTL 62 2 4.72 6.0E-6 34204 D2Mgh7 34461 D2Mgh12 35423 D2Rat41 insulin secretion trait (VT:0003564) plasma insulin level (CMO:0000342) impaired glucose tolerance;increased circulating insulin level;increased insulin secretion hyperinsulinism;type 2 diabetes mellitus 1302801 15266047 62007;70972 Ensa;Hao2 2 177516922 235592880 1 - by flanking markers 2 156142685 210636169 1 - by flanking markers 10017 60985 GK/KyoSwe BN 2 158159186 217498710 1 - by flanking markers 2 150540301 202447032 1 - by flanking markers 1354610 rat Bw34 Body weight QTL 34 1 4.1 38564 D1Rat140 34194 D1Mgh14 37184 D1Rat188 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893 15452030 1 167997630 285604895 1 - by flanking markers 1 154074905 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 278228889 1 - by flanking markers 1 151162512 256448636 1 - by flanking markers 1354611 rat Despr2 Despair related QTL 2 3 3.03 0.0028 1.9 38318 D3Rat71 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 3 108960777 153960777 5 - by peak with adj size 3 97595472 142595472 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 3 102466149 147466149 5 - by peak with adj size 3 97084464 142084464 5 - by peak with adj size 1354612 rat Foco1 Food consumption QTL 1 4 8.87 37592 D4Rat141 35625 D4Rat14 34943 D4Rat30 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) abnormal food intake Adrenal Insufficiency 1302889 15252022 4 44024417 210231569 1 - by flanking markers 4 41729771 151158666 1 - by flanking markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 4 43414792 146942075 1 - by flanking markers 4 44463908 148090542 1 - by flanking markers 1354613 rat Kidm14 Kidney mass QTL 14 17 6.2 35176 D17Rat2 36011 D17Rat17 38884 D17Rat94 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight hypertension 1302893 15452030 17 5553716 39651411 1 - by flanking markers 17 9988620 42344987 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 37790462 1 - by flanking markers 17 4299130 35837242 1 - by flanking markers 1354614 rat Hpcl1 Hepatic cholesterol level QTL 1 10 3.3 33909 D10Mit4 3138 Myh3 33909 D10Mit4 liver cholesterol amount (VT:0010498) liver cholesterol level (CMO:0001597) abnormal cellular cholesterol metabolism;increased cholesterol level 629576 9600105 69423 Srebf1 10 36354729 53396227 1 - by flanking markers 10 36649906 53800677 1 - by flanking markers 61098 68049 BXH/Ipcv HXB-1-43/Ipcv 10 36584373 53645194 1 - by flanking markers 10 35392267 51793994 1 - by flanking markers 1354615 rat Cm32 Cardiac mass QTL 32 1 5.2 35220 D1Rat29 37184 D1Rat188 36105 D1Rat51 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 1 110018554 226102807 1 - by flanking markers 1 103149923 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 219232156 1 - by flanking markers 1 102813953 201278233 1 - by flanking markers 1354616 rat Despr12 Despair related QTL 12 6 0.0012 2.1 35963 D6Rat46 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894;1358767 15457344;15685431 Stresp10 (maps to same region) 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 1354617 rat Bp240 Blood pressure QTL 240 2 4.0 38976 D2Rat124 41788 D2Rat275 36902 D2Rat270 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial blood pressure Metabolic Syndrome;hypertension 1302893 15452030 2 45317613 103494306 1 - by flanking markers 2 24496771 82826337 2 - by one flank and peak markers Intercross 10021 10022 LH/Mav LN/Mav 2 26186097 83819822 1 - by flanking markers 2 26917817 81754745 1 - by flanking markers 1354618 rat Kidm15 Kidney mass QTL 15 1 5.0 36105 D1Rat51 37184 D1Rat188 40876 D1Rat278 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight hypertension 1302893 15452030 1 173583273 226102807 1 - by flanking markers 1 159782445 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 167394665 219232156 1 - by flanking markers 1 156677124 201278233 1 - by flanking markers 1354619 rat Bp242 Blood pressure QTL 242 17 6.3 38884 D17Rat94 35473 D17Rat58 37494 D17Rat98 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial systolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 17 30089871 75089871 4 - by one flank marker only 17 47055924 81039660 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 28413148 73413148 4 - by one flank marker only 17 24599340 69599340 4 - by one flank marker only 1354620 rat Kidm19 Kidney mass QTL 19 1 4.0 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354621 rat Rf47 Renal function QTL 47 13 3.7 39804 D13Rat111 40468 D13Rat163 35997 D13Rat26 kidney renin amount (VT:0010559) kidney renin level (CMO:0002166) abnormal circulating renin level hypertension 1302893 15452030 13 40421740 112605698 1 - by flanking markers 13 32030139 105788017 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 13 35301263 107975663 1 - by flanking markers 13 30395351 101056920 1 - by flanking markers 1354622 rat Kidm16 Kidney mass QTL 16 2 3.0 41788 D2Rat275 36962 D2Rat63 38960 D2Rat93 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight hypertension 1302893 15452030 2 103494092 257699856 1 - by flanking markers 2 82826122 231465091 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 83819608 239166203 1 - by flanking markers 2 81754530 222436696 1 - by flanking markers 1354623 rat Rf46 Renal function QTL 46 1 3.8 35220 D1Rat29 38564 D1Rat140 34922 D1Rat43 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) abnormal circulating creatinine level hypertension 1302893 15452030 1 110018554 167997883 1 - by flanking markers 1 103149923 154075310 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 161784422 1 - by flanking markers 1 102813953 151162766 1 - by flanking markers 1354624 rat Cm35 Cardiac mass QTL35 1 5.7 37560 D1Rat155 34194 D1Mgh14 33945 D1Mit18 heart left ventricle mass (VT:0007031) calculated heart weight (CMO:0000073) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 1 199702920 285604895 1 - by flanking markers 1 181524849 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 192639698 278228889 1 - by flanking markers 1 177227632 256448636 1 - by flanking markers 1354625 rat Despr7 Despair related QTL 7 16 3.16 0.016 2.0 40052 D16Rat75 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 16 1612700 46612700 5 - by peak with adj size 16 1632183 46632183 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 16 1728297 46728297 5 - by peak with adj size 16 1 44977551 5 - by peak with adj size 1354626 rat Bvd1 Brain ventricular dilatation QTL 1 9 3.73 0.001 38048 D9Rat90 36325 D9Rat1 35789 D9Rat2 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 9 81176785 119437586 1 - by flanking markers 9 73454285 110864247 1 - by flanking markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 9 81411073 119983851 1 - by flanking markers 9 75712843 111552878 1 - by flanking markers 1354627 rat Despr14 Despair related QTL 14 8 0.0056 2.0 37742 D8Rat163 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 8 10411269 55411269 5 - by peak with adj size 8 9008612 54008612 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 8 10388439 55388439 5 - by peak with adj size 8 7688955 52688955 5 - by peak with adj size 1354628 rat Stl13 Serum triglyceride level QTL 13 17 3.8 38772 D17Rat102 35585 D17Rat151 36011 D17Rat17 blood triglyceride amount (VT:0002644) blood triglyceride level (CMO:0000118) abnormal triglyceride level;increased circulating VLDL cholesterol level;increased circulating triglyceride level Hypercholesterolemia;Hypertriglyceridemia;Metabolic Syndrome 1302893 15452030 17 25980198 65440857 1 - by flanking markers 17 27118351 71570057 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 24030618 63676140 1 - by flanking markers 17 21293039 60781592 1 - by flanking markers 1354629 rat Scl31 Serum cholesterol level QTL 31 17 4.1 38884 D17Rat94 35585 D17Rat151 36329 D17Rat32 blood cholesterol amount (VT:0000180) blood total cholesterol level (CMO:0000051) abnormal circulating cholesterol level;increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1302893 15452030 17 60186503 65440857 2 - by one flank and peak markers 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 58397260 63676140 2 - by one flank and peak markers 17 50890908 60781592 2 - by one flank and peak markers 1354630 rat Cm34 Cardiac mass QTL 34 17 8.7 35176 D17Rat2 35473 D17Rat58 38884 D17Rat94 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 17 5553716 75089871 1 - by flanking markers 17 9988620 81039660 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 73413148 1 - by flanking markers 17 4299130 69599340 1 - by flanking markers 1354631 rat Swd2 Spike wave discharge measurement QTL 2 5 3.64 2.0E-4 39168 D5Rat99 39700 D5Rat185 34206 D5Mgh15 brain electrophysiology trait (VT:0010557) brain total spike-and-wave discharge duration (CMO:0001740) increased spike-wave discharge type II childhood absence epilepsy 1302436 15270755 5 161060798 174683006 1 - by flanking markers 5 157691737 170688737 1 - by flanking markers Intercross 10000 737924 ACI/N WAG/Rij 5 157319671 171194163 1 - by flanking markers 5 151113452 164465185 1 - by flanking markers 1354632 rat Scl29 Serum cholesterol level QTL 29 6 3.74 35390 D6Rat36 36729 D6Rat23 11141 D6Arb12 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 737686 14724732 6 50735827 84567936 1 - by flanking markers 6 35883625 74436995 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 6 37608980 75023446 1 - by flanking markers 6 35098709 71636405 1 - by flanking markers 1354633 rat Bw28 Body weight QTL 28 19 6.04 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 body mass (VT:0001259) body weight (CMO:0000012) weight loss Adrenal Insufficiency 1302889 15252022 3094 Nr3c2 19 42098191 52509704 1 - by flanking markers 19 25548711 39854409 2 - by one flank and peak markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 19 31194301 41686140 1 - by flanking markers 19 27530207 37947399 1 - by flanking markers 1354634 rat Kidm12 Kidney mass QTL 12 1 3.9 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) abnormal kidney weight hypertension 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354635 rat Bp245 Blood pressure QTL 245 17 6.0 38884 D17Rat94 35473 D17Rat58 36329 D17Rat32 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure;increased systemic arterial blood pressure Metabolic Syndrome;hypertension 1302893 15452030 17 50537489 75089871 2 - by one flank and peak markers 17 36039660 81039660 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 48660252 73413148 2 - by one flank and peak markers 17 42073160 69599340 2 - by one flank and peak markers 1354636 rat Lmblg1 Limb length QTL 1 1 6.4 38564 D1Rat140 37184 D1Rat188 36105 D1Rat51 tibia length (VT:0004357) tibia length (CMO:0000450) abnormal tibia morphology 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354637 rat Scl30 Serum cholesterol level QTL 30 7 3.7 35068 D7Rat32 39012 D7Rat98 34051 D7Mit28 blood cholesterol amount (VT:0000180) blood total cholesterol level (CMO:0000051) abnormal circulating cholesterol level;increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1302893 15452030 7 25506703 57077089 1 - by flanking markers 7 21790655 53398255 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 7 25365633 57064364 1 - by flanking markers 7 19654317 49753746 1 - by flanking markers 1354638 rat Insul1 Insulin level QTL 1 17 4.8 35176 D17Rat2 35473 D17Rat58 36329 D17Rat32 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) abnormal circulating insulin level Metabolic Syndrome 1302893 15452030 17 5553716 75089871 1 - by flanking markers 17 9988620 81039660 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 73413148 1 - by flanking markers 17 4299130 69599340 1 - by flanking markers 1354639 rat Spl5 Serum phospholipid level QTL 5 7 3.9 35068 D7Rat32 10880 D7Mgh22 34051 D7Mit28 blood LDL phospholipid amount (VT:0010505) blood low density lipoprotein phospholipid level (CMO:0001568) abnormal circulating LDL cholesterol level hypertension 1302893 15452030 7 25506703 60319594 1 - by flanking markers 7 21790655 56589443 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 7 25365633 60317612 1 - by flanking markers 7 19654317 52888450 1 - by flanking markers 1354640 rat Scl32 Serum cholesterol level QTL 32 17 5.4 38884 D17Rat94 35585 D17Rat151 36331 D17Mit12 blood HDL cholesterol amount (VT:0000184) blood high density lipoprotein cholesterol level (CMO:0000052) abnormal circulating HDL cholesterol level;increased circulating HDL cholesterol level Hypercholesterolemia;Metabolic Syndrome 1302893 15452030 17 20440857 65440857 4 - by one flank marker only 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 18676140 63676140 4 - by one flank marker only 17 15781592 60781592 4 - by one flank marker only 1354641 rat Bvd2 Brain ventricular dilatation QTL 2 10 6.36 0.001 39928 D10Rat189 35254 D10Rat2 41382 D10Rat136 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 10 96247437 110568670 1 - by flanking markers 10 79981838 110718848 5 - by peak with adj size backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 10 96520816 110992275 1 - by flanking markers 10 93223816 107057807 1 - by flanking markers 1354642 rat Despr15 Despair related QTL 15 20 0.0027 3.1 35188 D20Rat1 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 20 1 26689404 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 20 1 24652101 5 - by peak with adj size 20 1 24159021 5 - by peak with adj size 1354643 rat Foco2 Food consumption QTL 2 1 7.17 1.0E-4 14.4 40798 D1Rat256 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) abnormal food intake Adrenal Insufficiency 1302889 15252022 1 35632458 80632458 5 - by peak with adj size 1 31371950 76371950 5 - by peak with adj size 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 1 34449112 79449112 5 - by peak with adj size 1 33449848 78449848 5 - by peak with adj size 1354644 rat Spl4 Serum phospholipid level QTL 4 7 4.9 35068 D7Rat32 39012 D7Rat98 34051 D7Mit28 blood phospholipid amount (VT:0006084) blood phospholipid level (CMO:0001169) abnormal circulating phospholipid level hypertension 1302893 15452030 7 25506703 57077089 1 - by flanking markers 7 21790655 53398255 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 7 25365633 57064364 1 - by flanking markers 7 19654317 49753746 1 - by flanking markers 1354645 rat Swd1 Spike wave discharge measurement QTL 1 9 3.91 1.2E-4 40510 D9Rat109 41672 D9Rat163 38536 D9Rat103 brain electrophysiology trait (VT:0010557) mean duration of a single type I spike-and-wave discharge train (CMO:0002064) increased spike-wave discharge type I childhood absence epilepsy 1302436 15270755 9 106780549 109609577 1 - by flanking markers 9 100495066 101209445 1 - by flanking markers Intercross 10000 737924 ACI/N WAG/Rij 9 107198926 110038814 1 - by flanking markers 9 101597509 102302863 1 - by flanking markers 1354646 rat Kidm18 Kidney mass QTL 18 1 5.7 38564 D1Rat140 34194 D1Mgh14 37184 D1Rat188 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 1 167997630 285604895 1 - by flanking markers 1 154074905 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 278228889 1 - by flanking markers 1 151162512 256448636 1 - by flanking markers 1354647 rat Despr8 Despair related QTL 8 1 3.41E-5 7.3 39666 D1Rat246 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 1 1 26064717 5 - by peak with adj size 1 1 24936947 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1 1 24368159 5 - by peak with adj size 1 1 24744506 5 - by peak with adj size 1354648 rat Bp239 Blood pressure QTL 239 2 0.001 2044 Adh1c 33739 D2Mit5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 629612;10755344 9260980;22912817 Bp389 (maps to same region) 2 86560306 262090818 1 - by flanking markers 2 66680209 235799396 1 - by flanking markers 1357190 SS.MNS-(Adh1-D2Mit5)/Mco 2 66828236 243550655 1 - by flanking markers 2 66118463 226797303 1 - by flanking markers 1354649 rat Kidm17 Kidney mass QTL 17 2 2.9 41788 D2Rat275 36081 D2Rat294 38960 D2Rat93 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 2 103494092 262435073 1 - by flanking markers 2 82826122 236153712 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 83819608 243901375 1 - by flanking markers 2 81754530 227146641 1 - by flanking markers 1354650 rat Despr5 Despair related QTL 5 9 4.01 0.0017 2.9 40738 D9Rat130 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894;2312611 15457344;19697080 Gluco54 (maps to same region) 9 3833388 48833388 5 - by peak with adj size 9 1 42602240 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 9 4986095 49986095 5 - by peak with adj size 9 1254084 46254084 5 - by peak with adj size 1354651 rat Lmblg2 Limb length QTL 2 17 6.0 35176 D17Rat2 35473 D17Rat58 38884 D17Rat94 tibia length (VT:0004357) tibia length (CMO:0000450) abnormal tibia morphology 1302893 15452030 17 5553716 75089871 1 - by flanking markers 17 9988620 81039660 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 73413148 1 - by flanking markers 17 4299130 69599340 1 - by flanking markers 1354652 rat Kidm20 Kidney mass QTL 20 1 4.3 37560 D1Rat155 34194 D1Mgh14 33945 D1Mit18 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 1 199702920 285604895 1 - by flanking markers 1 181524849 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 192639698 278228889 1 - by flanking markers 1 177227632 256448636 1 - by flanking markers 1354653 rat Despr9 Despair related QTL 9 1 1.9E-4 2.7 39152 D1Rat147 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 1 192322095 237322095 5 - by peak with adj size 1 172723568 217723568 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1 185390068 230390068 5 - by peak with adj size 1 167909849 212909849 5 - by peak with adj size 1354654 rat Spl7 Serum phospholipid level QTL 7 17 5.5 38884 D17Rat94 35585 D17Rat151 36329 D17Rat32 blood phospholipid amount (VT:0006084) blood phospholipid level (CMO:0001169) abnormal circulating phospholipid level hypertension 1302893 15452030 17 60186503 65440857 2 - by one flank and peak markers 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 58397260 63676140 2 - by one flank and peak markers 17 50890908 60781592 2 - by one flank and peak markers 1354655 rat Bp241 Blood pressure QTL 241 13 3.9 41340 D13Rat116 40468 D13Rat163 41588 D13Rat128 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial systolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 13 46437046 112605698 1 - by flanking markers 13 37458331 105788017 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 13 62975663 107975663 4 - by one flank marker only 13 56056920 101056920 4 - by one flank marker only 1354656 rat Bvd3 Brain ventricular dilatation QTL 3 11 3.64 0.001 41256 D11Rat61 37512 D11Rat50 37942 D11Rat46 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890;68196 15473982;11178739 Bvd6 (sub_region) 11 75797786 90087579 1 - by flanking markers 11 77341660 84841212 2 - by one flank and peak markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 11 72720029 86994795 1 - by flanking markers 11 69446070 82846715 1 - by flanking markers 1354657 rat Despr13 Despair related QTL 13 15 0.0022 2.6 36516 D15Rat1 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 15 1 34660252 5 - by peak with adj size 15 1 31488303 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 15 1 30597196 5 - by peak with adj size 15 1 29912054 5 - by peak with adj size 1354658 rat Spl8 Serum phospholipid level QTL 8 17 3.8 38884 D17Rat94 35585 D17Rat151 38772 D17Rat102 blood VLDL phospholipid amount (VT:0010507) blood very low density lipoprotein phospholipid level (CMO:0001571) abnormal circulating VLDL cholesterol level hypertension 1302893 15452030 17 1 65440857 2 - by one flank and peak markers 17 1 71570057 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 1 63676140 2 - by one flank and peak markers 17 1 60781592 2 - by one flank and peak markers 1354659 rat Scl68 Serum cholesterol level QTL 68 17 3.9 38884 D17Rat94 35585 D17Rat151 36331 D17Mit12 blood VLDL cholesterol amount (VT:0005144) blood very low density lipoprotein cholesterol level (CMO:0000648) abnormal circulating VLDL cholesterol level hypertension 1302893 15452030 17 20440857 65440857 4 - by one flank marker only 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 18676140 63676140 4 - by one flank marker only 17 15781592 60781592 4 - by one flank marker only 1354660 rat Salc1 Saline consumption QTL 1 4 11.26 20.8 37592 D4Rat141 35625 D4Rat14 34943 D4Rat30 drinking behavior trait (VT:0001422) saline drink intake rate (CMO:0001627) abnormal drinking behavior Adrenal Insufficiency 1302889 15252022 4 44024417 210231569 1 - by flanking markers 4 41729771 151158666 1 - by flanking markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 4 43414792 146942075 1 - by flanking markers 4 44463908 148090542 1 - by flanking markers 1354661 rat Bw33 Body weight QTL 33 1 5.2 38564 D1Rat140 34194 D1Mgh14 36021 D1Rat115 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893 15452030 1 167997630 285604895 1 - by flanking markers 1 154074905 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 278228889 1 - by flanking markers 1 151162512 256448636 1 - by flanking markers 1354662 rat Rf49 Renal function QTL 49 17 2.9 38884 D17Rat94 35473 D17Rat58 38772 D17Rat102 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) abnormal circulating creatinine level hypertension 1302893 15452030 17 1 75089871 2 - by one flank and peak markers 17 1 81039660 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 1 73413148 2 - by one flank and peak markers 17 1 69599340 2 - by one flank and peak markers 1354663 rat Bvd5 Brain ventricular dilatation QTL 5 17 3.51 0.001 33882 D17Mit2 41762 D17Rat154 41762 D17Rat154 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 17 35195242 87045172 1 - by flanking markers 17 38353858 92741218 1 - by flanking markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 17 33303627 85321557 1 - by flanking markers 17 31990784 81292925 1 - by flanking markers 1354664 rat Slep2 Serum leptin concentration QTL 2 6 4.49 0.08 37142 D6Rat80 36729 D6Rat23 35390 D6Rat36 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 737686 14724732 dominant 6 1111498 84567936 1 - by flanking markers 6 1301952 74436995 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 6 1120393 75023446 1 - by flanking markers 6 16536140 71636405 1 - by flanking markers 1354665 rat Stl10 Serum triglyceride level QTL 10 4 3.57 34200 D4Mgh1 35625 D4Rat14 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 4 18184531 44024417 1 - by flanking markers 4 17617956 41729771 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 4 18222187 43414792 1 - by flanking markers 4 21333343 44463908 1 - by flanking markers 1354666 rat Bp244 Blood pressure QTL 244 13 4.9 37316 D13Rat53 40468 D13Rat163 40948 D13Rat120 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial diastolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 13 1 112605698 2 - by one flank and peak markers 13 1 105788017 2 - by one flank and peak markers Intercross 10021 10022 LH/Mav LN/Mav 13 1 107975663 2 - by one flank and peak markers 13 1 101056920 2 - by one flank and peak markers 1357335 rat Bw39 Body weight QTL 39 1 3.3 32.0 2870 Igf2 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) obesity 69707;1303386 9530522;14640890 1 222722921 270717037 1 - by flanking markers 1 202906624 247322277 1 - by flanking markers backcross 61107 61110 BB/OK SHR/Mol 1 215828102 260828102 4 - by one flank marker only 1 197814409 242814409 4 - by one flank marker only 1357336 rat Gluco6 Glucose level QTL 6 7 3.4 33670 D7Mit2 33969 D7Mit4 33749 D7Mit3 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543) abnormal glucose tolerance;impaired glucose tolerance Insulin Resistance;glucose intolerance 619533 12016513 additive 7 104437717 125794079 1 - by flanking markers 7 100273797 123191595 1 - by flanking markers 629499 BXS/Ipcv 7 103867802 126080176 1 - by flanking markers 7 94811326 116294265 1 - by flanking markers 1357337 rat Gluco3 Glucose level QTL 3 12 4.0E-4 34025 D12Mit8 34439 D12Mgh1 adipocyte glucose uptake trait (VT:0004185) absolute change in adipocyte glucose uptake (CMO:0000873) abnormal adipocyte glucose uptake Metabolic Syndrome;type 2 diabetes mellitus 61078 9171835 dominant 12 1 15941791 4 - by one flank marker only 12 1 12240883 4 - by one flank marker only 61096 61097 SHR/NCruk WKY/NCruk 1357338 rat Stl17 Serum triglyceride level QTL 17 7 3.23 34096 D7Mgh4 34499 D7Mgh7 34555 D7Mgh6 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level familial hyperlipidemia 1357168 11374884 7 77531388 122402852 1 - by flanking markers 7 74244916 119494569 1 - by flanking markers 67935 1357345 WOKW DA/K 7 77428234 122421148 1 - by flanking markers 7 69736356 112729554 1 - by flanking markers 1357339 rat Stl14 Serum triglyceride level QTL 14 7 3.45 1.0E-4 33780 D7Mit1 34096 D7Mgh4 33670 D7Mit2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia;Metabolic Syndrome 1357168 11374884 7 122402980 141760721 1 - by flanking markers 7 119494698 141116327 1 - by flanking markers 67935 1357345 WOKW DA/K 7 122421276 143965415 1 - by flanking markers 7 112729683 133492707 1 - by flanking markers 1357340 rat Bp250 Blood pressure QTL 250 10 1.0E-4 631289 D10M11Mit119 631291 D10M11Mit84 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619625 9607182 10 100446517 112146223 4 - by one flank marker only 10 101848470 146848470 4 - by one flank marker only 631588 SS.MNS-(D10Mit11-Vamp2)/Mco 1357341 rat Gluco5 Glucose level QTL 5 4 6.4 11310 D4Bro1 adipocyte free fatty acid secretion trait (VT:0010465) absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446) abnormal circulating free fatty acids level Metabolic Syndrome;type 2 diabetes mellitus 61078 9171835 recessive 4 1 29789968 5 - by peak with adj size 4 1 28615362 5 - by peak with adj size 61096 61097 SHR/NCruk WKY/NCruk 4 1 29778604 5 - by peak with adj size 4 1 33250345 5 - by peak with adj size 1357342 rat Bw40 Body weight QTL 40 4 0.001 60732 D4Mit6 3753 Spr body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 69707 9530522 3197;3753 Npy;Spr 4 141978848 181496612 1 - by flanking markers 4 75732943 119369308 1 - by flanking markers 61107 1357346 BB/OK BB.SHR-(D4Mit6-Spr)/K 4 77307388 116916073 1 - by flanking markers 4 76647384 117676292 1 - by flanking markers 1357343 rat Gluco4 Glucose level QTL 4 4 2.0E-5 11310 D4Bro1 adipocyte glucose uptake trait (VT:0004185) adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874) abnormal adipocyte glucose uptake Metabolic Syndrome;type 2 diabetes mellitus 61078 9171835 recessive 4 1 29789968 5 - by peak with adj size 4 1 28615362 5 - by peak with adj size 61096 61097 SHR/NCruk WKY/NCruk 4 1 29778604 5 - by peak with adj size 4 1 33250345 5 - by peak with adj size 1357344 rat Bp249 Blood pressure QTL 249 10 1.0E-4 66552 D10Mco1 66563 D10Mco6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619626 9096100 10 68786307 101157704 1 - by flanking markers 10 69986912 102587587 1 - by flanking markers 631587 631588 SS.MNS-(D10M11Mit119-D10Mit11)/Jr SS.MNS-(D10Mit11-Vamp2)/Mco 10 69123603 101482600 1 - by flanking markers 10 66743655 98003205 1 - by flanking markers 1357396 rat Bw44 Body weight QTL 44 5 4.19 34216 D5Mgh6 34041 D5Mit5 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1357168 11374884 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers 67935 1357345 WOKW DA/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 1357397 rat Bw41 Body weight QTL 41 1 4.19 1.0E-4 34662 D1Mgh2 33660 D1Mit9 33660 D1Mit9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1357168 11374884 1 24875821 50204515 1 - by flanking markers 1 22842898 43840628 1 - by flanking markers 67935 1357345 WOKW DA/K 1 23406428 49547474 1 - by flanking markers 1 22340647 49361612 1 - by flanking markers 1357398 rat Slep3 Serum leptin concentration QTL 3 8 3.43 33858 D8Mit4 33628 D8Mit6 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 1357168 11374884 8 11331573 44187546 1 - by flanking markers 8 9581375 44484215 1 - by flanking markers 67935 1357345 WOKW DA/K 8 11373509 45712344 1 - by flanking markers 8 9712463 41866876 1 - by flanking markers 1357399 rat Bw45 Body weight QTL 45 1 3.05 11060 D1Wox23 10674 D1Mgh12 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body weight Metabolic Syndrome;obesity 1357168 11374884 1 232642738 270717037 1 - by flanking markers 1 212121314 247322277 1 - by flanking markers 67935 1357345 WOKW DA/K 1 225689973 270689973 4 - by one flank marker only 1 206329708 251329708 4 - by one flank marker only 1357400 rat Bw62 Body weight QTL62 1 4.05 34662 D1Mgh2 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) increased total body fat amount obesity 1357168 11374884 1 24875821 69875821 4 - by one flank marker only 1 22842898 67842898 4 - by one flank marker only 67935 1357345 WOKW DA/K 1 23406428 68406428 4 - by one flank marker only 1 22340647 67340647 4 - by one flank marker only 1357401 rat Bw43 Body weight QTL 43 1 3.75 34662 D1Mgh2 33660 D1Mit9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1357168 11374884 1 24875821 50204515 1 - by flanking markers 1 22842898 43840628 1 - by flanking markers 67935 1357345 WOKW DA/K 1 23406428 49547474 1 - by flanking markers 1 22340647 49361612 1 - by flanking markers 1357402 rat Bw46 Body weight QTL 46 5 4.47 34216 D5Mgh6 34041 D5Mit5 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body weight Metabolic Syndrome;obesity 1357168 11374884 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers 67935 1357345 WOKW DA/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 1357403 rat Slep4 Serum leptin concentration QTL 4 16 3.91 33638 D16Mit4 10660 D16Mgh3 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 1357168 11374884 16 8979177 29485011 1 - by flanking markers 16 9964433 30560825 1 - by flanking markers 67935 1357345 WOKW DA/K 16 1 10660736 4 - by one flank marker only 16 1 9639137 4 - by one flank marker only 1357404 rat Bw42 Body weight QTL 42 1 4.49 1.0E-4 11060 D1Wox23 10674 D1Mgh12 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1357168 11374884 1 232642738 270717037 1 - by flanking markers 1 212121314 247322277 1 - by flanking markers 67935 1357345 WOKW DA/K 1 225689973 270689973 4 - by one flank marker only 1 206329708 251329708 4 - by one flank marker only 1357990 rat Ael1 Aortic elastin QTL 1 2 3.1 9.1E-4 9.2 43467 D2Got24 aorta elastin amount (VT:0003905) aortic elastin decreased aorta elastin content cardiovascular system disease 1334448 15668357 dominant 2 38074337 83074337 5 - by peak with adj size 2 18905511 63905511 5 - by peak with adj size 60985 1357985 BN LOU/Ins 2 19016465 64016465 5 - by peak with adj size 2 19076825 64076825 5 - by peak with adj size 1357991 rat Ael2 Aortic elastin QTL 2 2 4.2 7.1E-5 10201 D2Wox26 aorta elastin amount (VT:0003905) aortic elastin decreased aorta elastin content cardiovascular system disease 1334448 15668357 recessive 60985 1357985 BN LOU/Ins 1358185 rat Ept6 Estrogen-induced pituitary tumorigenesis QTL 6 3 6.7 11.0 41830 D3Rat277 34347 D3Mgh16 34186 D3Mgh9 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept17 (maps to same region) 3 11361817 31948244 1 - by flanking markers 3 6373454 22341164 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 3 571136 6000866 2 - by one flank and peak markers 3 6537645 10778823 2 - by one flank and peak markers 1358186 rat Ept2 Estrogen-induced pituitary tumorigenesis QTL 2 3 8.3 35451 D3Rat21 39050 D3Rat130 35795 D3Rat26 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept16 (maps to same region) 3 55227748 121789152 1 - by flanking markers 3 44551542 110215186 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 3 48562146 115249962 1 - by flanking markers 3 47233430 110362260 1 - by flanking markers 1358187 rat Emca1 Estrogen-induced mammary cancer QTL 1 5 4.4 36275 D5Rat57 35961 D5Rat53 36187 D5Rat30 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1358124;2291885;1642522 15611180;18057545;16885383 Emca8 (maps to same region) 5 106951761 158498929 1 - by flanking markers 5 103677659 155120876 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 5 102945579 154732228 1 - by flanking markers 5 99216724 148607142 1 - by flanking markers 1358188 rat Ept9 Estrogen-induced pituitary tumorigenesis QTL 9 10 3.9 7.0 35256 D10Rat11 36203 D10Rat27 33690 D10Mit7 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept18 (maps to same region) 10 74127968 99184058 1 - by flanking markers 10 77092169 100633512 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 10 75983805 99492217 1 - by flanking markers 10 73453136 96120911 1 - by flanking markers 1358189 rat Cstrr1 Cold stress response QTL 1 1 1.0E-4 60784 D1Wox29 11359 D1Arb21 catecholamine amount (VT:0010543) urine norepinephrine level (CMO:0001629) abnormal sensory capabilities/reflexes/nociception;increased circulating noradrenaline level;increased systemic arterial blood pressure autonomic nervous system disease;hypertension 1302892 15480093 Bp84 (sub_region) 1 131822204 206277202 1 - by flanking markers 1 124614679 187092492 1 - by flanking markers 1302636 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers 1358190 rat Ept1 Estrogen-induced pituitary tumorigenesis QTL 1 6 4.4 1357998 D6Rat150 35683 D6Rat39 37142 D6Rat80 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept15 (maps to same region) 6 8018013 31405507 1 - by flanking markers 6 1 8184962 2 - by one flank and peak markers 737892 1358153 ACI/SegHsd COP/CrCrl 6 8083222 21515439 1 - by flanking markers 6 9843312 20338915 1 - by flanking markers 1358191 rat Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 1 3.8 34971 D1Rat81 37294 D1Rat133 36083 D1Rat119 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449 15687265 1 217288730 272245217 1 - by flanking markers 1 197770157 250119666 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 1 210360774 264802828 1 - by flanking markers 1 192825253 243914732 1 - by flanking markers 1358192 rat Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 1 3.4 40964 D1Rat259 37688 D1Rat192 37688 D1Rat192 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449 15687265 1 25764938 79995195 1 - by flanking markers 1 23633441 77148378 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 1 24297799 78748000 1 - by flanking markers 1 77494165 122494165 4 - by one flank marker only 1358193 rat Emca2 Estrogen-induced mammary cancer QTL 2 18 1.6 37514 D18Rat43 36548 D18Rat27 36444 D18Rat21 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1358124;2291885;1642522 15611180;18057545;16885383 Emca7 (interacts with) 18 18780787 67591915 1 - by flanking markers 18 18562790 66652461 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 18 19031030 68436105 1 - by flanking markers 18 18007599 63571040 1 - by flanking markers 1358200 rat Insglur2 Insulin/glucose ratio QTL 2 19 4.1 41262 D19Rat57 2993 Lcat blood glucose amount (VT:0000188) serum glucose level (CMO:0000543);serum insulin level (CMO:0000358) insulin resistance Insulin Resistance 619533 12016513 19 48783830 70892012 1 - by flanking markers 19 35784966 57234802 1 - by flanking markers 629499 BXS/Ipcv 19 37916799 60220451 1 - by flanking markers 19 33838214 55283146 1 - by flanking markers 1358201 rat Gluco12 Glucose level QTL12 4 1.6 35913 D4Rat10 10800 D4Wox27 10800 D4Wox27 adipocyte glucose uptake trait (VT:0004185) adipocyte maximal glucose uptake (CMO:0000870) abnormal glucose homeostasis;abnormal intestinal glucose absorption Insulin Resistance 1357415 15752738 4 3096419 26659360 1 - by flanking markers 4 460590 26280781 1 - by flanking markers 631286 631577 WKY/Izm SHR/Izm 4 3044114 26753655 1 - by flanking markers 4 5218392 29593287 1 - by flanking markers 1358202 rat Gluco11 Glucose level QTL 11 4 2.4 0.02 35409 D4Rat34 34338 D4Mgh11 11381 D4Mgh17 adipocyte glucose uptake trait (VT:0004185) absolute change in adipocyte glucose uptake (CMO:0000873) abnormal glucose homeostasis;abnormal intestinal glucose absorption Insulin Resistance 1357415 15752738 4 151090671 230565226 1 - by flanking markers 4 85014031 171204531 1 - by flanking markers 631286 631577 WKY/Izm SHR/Izm 4 86438317 168047091 1 - by flanking markers 4 85379421 167139601 1 - by flanking markers 1358203 rat Stl19 Serum triglyceride level QTL 19 4 2.8 0.002 10800 D4Wox27 38728 D4Rat122 35913 D4Rat10 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level;increased triglyceride level Hypertriglyceridemia;Metabolic Syndrome 1357415 15752738 4 3096322 64737743 1 - by flanking markers 4 460493 64750077 1 - by flanking markers 631286 631577 WKY/Izm SHR/Izm 4 3044017 64915903 1 - by flanking markers 4 5218294 65958103 1 - by flanking markers 1358204 rat Insglur1 Insulin/glucose ratio QTL 1 3 3.8 33608 D3Mit14 33927 D3Mit3 33808 D3Mit4 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543);serum insulin level (CMO:0000358) insulin resistance Insulin Resistance 619533 12016513 additive 3 129091119 148388048 1 - by flanking markers 3 115996080 136402080 1 - by flanking markers 629499 BXS/Ipcv 3 120917788 141971336 1 - by flanking markers 3 115638168 135181505 1 - by flanking markers 1358292 rat Cm37 Cardiac mass QTL 37 1 6.2 8.1E-7 17.5 36866 D1Rat73 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1334448 15668357 1 223613389 268613389 5 - by peak with adj size 1 201920676 246920676 5 - by peak with adj size 60985 1357985 BN LOU/Ins 1 216324817 261324817 5 - by peak with adj size 1 196248093 241248093 5 - by peak with adj size 1358293 rat Bw38 Body weight QTL 38 3 6.0 3.1E-6 18.6 1358021 D3Wox33 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;increased body weight 1334448 15668357 60985 1357985 BN LOU/Ins 3 56735995 101735995 5 - by peak with adj size 1358294 rat Bw37 Body weight QTL 37 1 5.0 1.1E-5 15.0 38940 D1Rat159 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;increased body weight 1334448 15668357 1 195776722 240776722 5 - by peak with adj size 1 176292515 221292515 5 - by peak with adj size 60985 1357985 BN LOU/Ins 1 188850303 233850303 5 - by peak with adj size 1 171310381 216310381 5 - by peak with adj size 1358295 rat Aocep1 Aortic cell protein QTL 1 17 6.1 7.1E-7 16.1 45488 D17Got80 thoracic aorta cellular protein amount (VT:0010598) aortic cell percentage increased cell mass cardiovascular system disease 1334448 15668357 17 46097577 91097577 5 - by peak with adj size 17 51995423 96995423 5 - by peak with adj size 60985 1357985 BN LOU/Ins 17 44356157 89356157 5 - by peak with adj size 17 40990005 85990005 5 - by peak with adj size 1358296 rat Ael3 Aortic elastin QTL 3 14 3.7 5.1E-4 9.7 38932 D14Rat36 aorta elastin amount (VT:0003905) aortic elastin decreased aorta elastin content cardiovascular system disease 1334448 15668357 additive 14 10333529 55333529 5 - by peak with adj size 14 10539919 55539919 5 - by peak with adj size 60985 1357985 BN LOU/Ins 14 10539977 55539977 5 - by peak with adj size 14 8267090 53267090 5 - by peak with adj size 1358352 rat Srcrt3 Stress Responsive Cort QTL 3 4 2.29 35847 D4Rat12 36143 D4Rat60 38656 D4Rat128 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal corticosterone level 1598980 16895972 4 36467227 208908285 1 - by flanking markers 4 8819982 149560340 2 - by one flank and peak markers 61105 61109 WKY/NHsd F344/NHsd 4 36615599 145611886 1 - by flanking markers 4 38465774 146803430 1 - by flanking markers 1358353 rat Srcrtb2 Stress Responsive Cort Basal QTL 2 5 3.48 0.003 40716 D5Rat124 34144 D5Mgh11 40386 D5Rat131 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal corticosterone level 1598980;2312611 16895972;19697080 Gluco47 (maps to same region) 5 23635353 80745947 1 - by flanking markers 5 19206257 77484299 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 5 18847913 76608178 1 - by flanking markers 5 18873947 74251464 1 - by flanking markers 1358354 rat Srcrt5 Stress Responsive Cort QTL 5 15 3.38 39122 D15Rat40 35321 D15Rat27 38106 D15Rat50 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 1598980 16895972 15 108749721 111756589 2 - by one flank and peak markers 15 106152589 107060711 2 - by one flank and peak markers 61105 61109 WKY/NHsd F344/NHsd 15 105348517 108369033 2 - by one flank and peak markers 15 98150001 99043291 2 - by one flank and peak markers 1358355 rat Srcrt4 Stress Responsive Cort QTL 4 6 6.39 38634 D6Rat103 36191 D6Rat6 39650 D6Rat111 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) decreased circulating corticosterone level 1598980;10053640 16895972;21029000 1595901 Serpina6 Srcrt6 (maps to same region) 6 112535839 132488565 1 - by flanking markers 6 104481235 123455207 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 6 104363890 147991367 2 - by one flank and peak markers 6 100364669 140994061 2 - by one flank and peak markers 1358356 rat Srcrt1 Stress Responsive Cort QTL1 2 3.66 39076 D2Rat170 36962 D2Rat63 39118 D2Rat139 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 1598980 16895972 2 194748054 257699856 1 - by flanking markers 2 167857161 231465091 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 2 175403337 239166203 1 - by flanking markers 2 161699179 222436696 1 - by flanking markers 1358357 rat Srcrtb1 Stress Responsive Cort Basal QTL 1 3 6.36 0.002 34186 D3Mgh9 37010 D3Rat49 35054 D3Rat55 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal corticosterone level 1598980 16895972 3 8648011 33340453 1 - by flanking markers 3 4010230 23762628 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 3 3285929 28136884 1 - by flanking markers 3 8658162 27494778 1 - by flanking markers 1358358 rat Sradr6 Stress Responsive Adrenal Weight QTL 6 18 2.49 11461 D18Mit1 37412 D18Rat40 39444 D18Rat96 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 18 15314027 60695947 1 - by flanking markers 18 12406975 62106220 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 18 15539427 61499684 1 - by flanking markers 18 11944299 59330563 1 - by flanking markers 1358359 rat Sradr1 Stress Responsive Adrenal Weight QTL 1 1 4.74 34037 D1Mit1 36432 D1Rat35 35308 D1Rat24 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 1 27404590 131959064 2 - by one flank and peak markers 1 28716493 124749065 2 - by one flank and peak markers 61105 61109 WKY/NHsd F344/NHsd 1 25951907 130917265 2 - by one flank and peak markers 1 30882023 123479925 2 - by one flank and peak markers 1358360 rat Sradr2 Stress Responsive Adrenal Weight QTL 2 2 10.24 38960 D2Rat93 38522 D2Rat164 41152 D2Rat220 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 2 152901512 192362483 1 - by flanking markers 2 133459258 157917105 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 2 133399373 173020198 1 - by flanking markers 2 129164097 152195315 1 - by flanking markers 1358361 rat Sradr5 Stress Responsive Adrenal Weight QTL 5 7 5.55 42215 D7Arb16 39144 D7Rat88 36731 D7Rat24 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980;2312611 16895972;19697080 Gluco53 (maps to same region) 7 51264830 118470274 1 - by flanking markers 7 47145687 114883369 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 7 51251919 118477612 1 - by flanking markers 7 43747012 108555253 1 - by flanking markers 1358362 rat Srcrt2 Stress Responsive Cort QTL 2 3 2.78 37510 D3Rat100 41228 D3Rat152 41162 D3Rat181 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) decreased circulating corticosterone level 1598980;2312611 16895972;19697080 Gluco46 (maps to same region) 3 44344790 146691568 1 - by flanking markers 3 35237920 134686096 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 3 39248391 140271184 1 - by flanking markers 3 38192233 133483320 1 - by flanking markers 1358363 rat Sradr3 Stress Responsive Adrenal Weight QTL 3 4 6.19 38656 D4Rat128 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 4 122835386 167835386 5 - by peak with adj size 4 56690161 101690161 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 4 58166424 103166424 5 - by peak with adj size 4 57486946 102486946 5 - by peak with adj size 1358364 rat Sradr4 Stress Responsive Adrenal Weight QTL 4 4 4.92 39054 D4Rat137 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 4 194518814 239518814 5 - by peak with adj size 4 132846974 177846974 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 4 128602727 173602727 5 - by peak with adj size 1358885 rat Bp251 Blood pressure QTL 251 3 3.8 0.06 35617 D3Rat54 36717 D3Rat17 40122 D3Rat186 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 3 15999179 133513825 1 - by flanking markers 3 10267741 121619110 1 - by flanking markers 60999 1302795 LEW HTG 3 10639528 127023997 1 - by flanking markers 3 14489145 121056321 1 - by flanking markers 1358886 rat Bp260 Blood pressure QTL 260 1 3.67 43423 D1Got228 38564 D1Rat140 36757 D1Rat71 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 1 167997883 253469877 1 - by flanking markers 1 154075310 231726050 1 - by flanking markers 60999 1302795 LEW HTG 1 161784422 246226103 1 - by flanking markers 1 151162766 225824951 1 - by flanking markers 1358887 rat Bw50 Body weight QTL 50 2 2.39 36213 D2Rat40 38576 D2Rat182 35250 D2Rat13 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386;61058 14640890;9329963 2 43009608 189197858 1 - by flanking markers 2 24474676 163154227 1 - by flanking markers 60999 1302795 LEW HTG 2 23837719 169852670 1 - by flanking markers 2 25413652 157142078 1 - by flanking markers 1358888 rat Bp264 Blood pressure QTL 264 3 4.43 35617 D3Rat54 36717 D3Rat17 34146 D3Mgh6 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 3 15999179 133513825 1 - by flanking markers 3 10267741 121619110 1 - by flanking markers 60999 1302795 LEW HTG 3 10639528 127023997 1 - by flanking markers 3 14489145 121056321 1 - by flanking markers 1358889 rat Bp261 Blood pressure QTL 261 5 2.86 37242 D5Rat77 38338 D5Rat108 60808 D5Wox25 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 5 97128212 137108002 2 - by one flank and peak markers 5 94084025 134872385 2 - by one flank and peak markers 60999 1302795 LEW HTG 5 93037304 133313852 2 - by one flank and peak markers 5 90067849 128034027 2 - by one flank and peak markers 1358890 rat Bp259 Blood pressure QTL 259 1 3.06 36757 D1Rat71 10674 D1Mgh12 41418 D1Rat304 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 1 237556833 270717037 1 - by flanking markers 1 216662939 247322277 1 - by flanking markers 60999 1302795 LEW HTG 1 230420627 282645769 2 - by one flank and peak markers 1 210702053 260522016 2 - by one flank and peak markers 1358891 rat Bp265 Blood pressure QTL 265 7 2.21 39938 D7Rat141 39652 D7Rat115 40784 D7Rat135 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 7 92475985 142937382 1 - by flanking markers 7 88583730 142441286 1 - by flanking markers 60999 1302795 LEW HTG 7 91832949 145158140 1 - by flanking markers 7 83591953 134666232 1 - by flanking markers 1358892 rat Kidm26 Kidney mass QTL 26 8 3.69 41522 D8Rat164 11222 D8Mgh3 36235 D8Rat35 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 8 29878681 105968579 1 - by flanking markers 8 28414004 103684785 1 - by flanking markers 60999 1302795 LEW HTG 8 29867983 106526740 1 - by flanking markers 8 27205715 99103503 1 - by flanking markers 1358893 rat Bp263 Blood pressure QTL 263 8 5.01 36904 D8Rat19 38484 D8Rat171 37072 D8Rat59 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) hypertension 1303386 14640890 8 100352377 131417183 1 - by flanking markers 8 98451122 127956046 1 - by flanking markers 60999 1302795 LEW HTG 8 100873811 133307652 4 - by one flank marker only 8 93965141 123900184 4 - by one flank marker only 1358894 rat Kidm24 Kidney mass QTL 24 2 4.03 38576 D2Rat182 36213 D2Rat40 38576 D2Rat182 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358895 rat Bp254 Blood pressure QTL 254 5 3.6 3.0E-4 36177 D5Rat9 38338 D5Rat108 41424 D5Rat156 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389;2316920 12545249;19556729 5 64593776 137108002 1 - by flanking markers 5 61080077 134872385 1 - by flanking markers 60999 1302795 LEW HTG 5 60072951 133313852 1 - by flanking markers 5 58829236 128034027 1 - by flanking markers 1358896 rat Bp262 Blood pressure QTL 262 8 2.89 41522 D8Rat164 11222 D8Mgh3 36235 D8Rat35 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure hypertension 1303386 14640890 8 29878681 105968579 1 - by flanking markers 8 28414004 103684785 1 - by flanking markers 60999 1302795 LEW HTG 8 29867983 106526740 1 - by flanking markers 8 27205715 99103503 1 - by flanking markers 1358897 rat Stresp6 Stress response QTL 6 10 4.17 0.022 10.2 33909 D10Mit4 34648 D10Mgh14 10949 D10Wox11 blood norepinephrine amount (VT:0005663) plasma norepinephrine level (CMO:0001010) increased circulating noradrenaline level 1332590 15547139 dominant 10 36354729 65109346 1 - by flanking markers 10 36649906 65379965 1 - by flanking markers 1302795 1354669 HTG BN/OrlIcoCrlf 10 36584373 66539843 1 - by flanking markers 10 35392267 64155584 1 - by flanking markers 1358898 rat Bp255 Blood pressure QTL 255 1 3.6 37732 D1Rat208 41060 D1Rat307 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 1 215445861 274378630 1 - by flanking markers 1 195927908 252497797 1 - by flanking markers 60999 1302795 LEW HTG 1 208517798 266948272 1 - by flanking markers 1 191019702 246062233 1 - by flanking markers 1358899 rat Kidm23 Kidney mass QTL 23 2 3.88 38576 D2Rat182 36213 D2Rat40 41538 D2Rat199 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358900 rat Bw48 Body weight QTL 48 2 4.88 35915 D2Rat61 36213 D2Rat40 34234 D2Mgh9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 2 88594475 189197988 1 - by flanking markers 2 163154358 227150051 1 - by flanking markers 60999 1302795 LEW HTG 2 68865414 169852800 1 - by flanking markers 2 157142078 211086598 2 - by one flank and peak markers 1358901 rat Cm38 Cardiac mass QTL 38 2 2.0 38576 D2Rat182 36213 D2Rat40 39512 D2Rat210 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358902 rat Bw47 Body weight QTL 47 1 1.67 36765 D1Rat27 36592 D1Rat64 38564 D1Rat140 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 1 95301716 204172352 1 - by flanking markers 1 90282040 184857893 1 - by flanking markers 60999 1302795 LEW HTG 1 94201400 197187904 1 - by flanking markers 1 90508614 180359386 1 - by flanking markers 1358903 rat Bp252 Blood pressure QTL 252 8 7.0 1.0E-4 36904 D8Rat19 38484 D8Rat171 37072 D8Rat59 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 8 100352377 131417183 1 - by flanking markers 8 98451122 127956046 1 - by flanking markers 60999 1302795 LEW HTG 8 100873811 133307652 4 - by one flank marker only 8 93965141 123900184 4 - by one flank marker only 1358904 rat Cm39 Cardiac mass QTL 39 2 2.26 38576 D2Rat182 36213 D2Rat40 41538 D2Rat199 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358905 rat Hrtrt17 Heart rate QTL 17 3 5.9 1.4E-5 10293 D3Mit7 34198 D3Mgh8 3632 Scn2a heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 1358133 9286932 2958;3632 Kcnj3;Scn2a 3 16721683 100057615 2 - by one flank and peak markers 3 6662627 88648585 2 - by one flank and peak markers 61010 61103 SHRSP WKY 3 10094081 93415837 2 - by one flank and peak markers 3 10861912 89878372 2 - by one flank and peak markers 1358906 rat Bp253 Blood pressure QTL 253 8 4.0 4.0E-4 36117 D8Rat46 36904 D8Rat19 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 8 61319409 100352529 1 - by flanking markers 8 43313902 98451660 1 - by flanking markers 60999 1302795 LEW HTG 8 44219197 100873963 1 - by flanking markers 8 40713066 93965294 1 - by flanking markers 1358907 rat Cm40 Cardiac mass QTL 40 8 1.89 41522 D8Rat164 11222 D8Mgh3 41522 D8Rat164 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 8 29878681 105968579 1 - by flanking markers 8 28414004 103684785 1 - by flanking markers 60999 1302795 LEW HTG 8 29867983 106526740 1 - by flanking markers 8 27205715 99103503 1 - by flanking markers 1358908 rat Bw49 Body weight QTL 49 2 3.36 36213 D2Rat40 38576 D2Rat182 34005 D2Mit8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 2 43009608 189197858 1 - by flanking markers 2 24474676 163154227 1 - by flanking markers 60999 1302795 LEW HTG 2 23837719 169852670 1 - by flanking markers 2 25413652 157142078 1 - by flanking markers 1358909 rat Kidm25 Kidney mass QTL 25 5 1.87 37242 D5Rat77 38338 D5Rat108 60808 D5Wox25 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight hypertension 1303386 14640890 5 97128212 137108002 2 - by one flank and peak markers 5 94084025 134872385 2 - by one flank and peak markers 60999 1302795 LEW HTG 5 93037304 133313852 2 - by one flank and peak markers 5 90067849 128034027 2 - by one flank and peak markers 1358910 rat Kidm27 Kidney mass QTL 27 2 5.77 38576 D2Rat182 36213 D2Rat40 35272 D2Rat19 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358911 rat Kidm28 Kidney mass QTL 28 2 5.42 38576 D2Rat182 36213 D2Rat40 38576 D2Rat182 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358912 rat Bw51 Body weight QTL 51 8 2.95 35388 D8Rat37 37072 D8Rat59 39574 D8Rat139 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 8 54031714 115113003 1 - by flanking markers 8 54364071 112242906 1 - by flanking markers 60999 1302795 LEW HTG 8 55435004 115812386 2 - by one flank and peak markers 8 51351728 107062046 2 - by one flank and peak markers 1358913 rat Cm41 Cardiac mass QTL 41 2 2.73 38576 D2Rat182 35693 D2Rat55 38266 D2Rat136 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 237043265 1 - by flanking markers 2 24474447 212169089 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 218957222 1 - by flanking markers 2 25413423 203928301 1 - by flanking markers 1358914 rat Bp266 Blood pressure QTL 266 7 39938 D7Rat141 39652 D7Rat115 35681 D7Rat5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 7 92475985 142937382 1 - by flanking markers 7 88583730 142441286 1 - by flanking markers 60999 1302795 LEW HTG 7 91832949 145158140 1 - by flanking markers 7 83591953 134666232 1 - by flanking markers 1358915 rat Stresp7 Stress response QTL 7 10 3.52 9.6 34718 D10Mgh23 11308 D10Wox20 11308 D10Wox20 blood norepinephrine amount (VT:0005663) plasma norepinephrine level (CMO:0001010) increased circulating noradrenaline level 1332590 15547139 codominant 10 81479737 90085597 1 - by flanking markers 10 68955627 110718848 5 - by peak with adj size 1302795 1354669 HTG BN/OrlIcoCrlf 10 81649775 90297007 1 - by flanking markers 10 78899655 87307728 1 - by flanking markers 1358916 rat Kidm22 Kidney mass QTL 22 1 3.32 36757 D1Rat71 10674 D1Mgh12 43423 D1Got228 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight hypertension 1303386 14640890 1 237556833 270717037 1 - by flanking markers 1 216662939 247322277 1 - by flanking markers 60999 1302795 LEW HTG 1 230420627 262031693 2 - by one flank and peak markers 1 210702053 240947965 2 - by one flank and peak markers 1358917 rat Cm42 Cardiac mass QTL 42 2 2.82 38576 D2Rat182 35693 D2Rat55 41538 D2Rat199 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 237043265 1 - by flanking markers 2 24474447 212169089 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 218957222 1 - by flanking markers 2 25413423 203928301 1 - by flanking markers 1359017 rat Hrtrt21 Heart rate QTL 21 10 2.4 36319 D10Rat26 42373 D10Rat267 40788 D10Rat145 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 625381 11882571 10 54914324 99914324 4 - by one flank marker only 10 68526078 101292630 2 - by one flank and peak markers Recombinant inbred 61098 61099 BXH/Ipcv HXB/Ipcv 10 55224855 100224855 4 - by one flank marker only 10 51772940 96772940 4 - by one flank marker only 1359018 rat Hrtrt20 Heart rate QTL 20 1 3.08 41012 D1Rat287 41110 D1Rat292 36460 D1Rat69 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 625381 11882571 1 208389496 228799992 2 - by one flank and peak markers 1 190114247 208110419 2 - by one flank and peak markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 1 201358068 221983732 2 - by one flank and peak markers 1 185356336 202902618 2 - by one flank and peak markers 1359019 rat Hrtrt19 Heart rate QTL 19 2 2.9 35849 D2Rat62 41066 D2Rat247 36962 D2Rat63 heart pumping trait (VT:2000009) heart rate (CMO:0000002) decreased heart rate Bradycardia;heart disease 625381 11882571 2 254867191 261576629 1 - by flanking markers 2 228663949 234266109 2 - by one flank and peak markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 2 236318496 243026643 1 - by flanking markers 2 219753301 226277316 1 - by flanking markers 1359020 rat Ppulsi2 Prepulse inhibition QTL 2 18 2.71 37738 D18Rat57 35282 D18Rat5 prepulse inhibition trait (VT:0003088) acoustic startle response measurement (CMO:0001519) abnormal prepulse inhibition schizophrenia 629579 12426667 18 53100479 76260776 1 - by flanking markers 18 54605732 77452533 1 - by flanking markers 10008 1358112 BN/SsNHsd WKY/NCrl 18 53861252 77151443 1 - by flanking markers 18 52292875 73997283 1 - by flanking markers 1359021 rat Bp271 Blood pressure QTL 271 8 1.8 34723 D8Mgh9 37038 D8Rat40 42849 D8Rat219 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure hypertension 625381 11882571 8 29548704 49334354 2 - by one flank and peak markers 8 27021985 49403011 2 - by one flank and peak markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 8 28168023 50708951 2 - by one flank and peak markers 8 26644912 46711092 2 - by one flank and peak markers 1359022 rat Ppulsi1 Prepulse inhibition QTL 1 2 3.63 36466 D2Rat34 36876 D2Rat88 prepulse inhibition trait (VT:0003088) acoustic startle response measurement (CMO:0001519) abnormal prepulse inhibition schizophrenia 629579 12426667 2 161739948 248335979 1 - by flanking markers 2 141755026 222281918 1 - by flanking markers 10008 1358112 BN/SsNHsd WKY/NCrl 2 142053350 228984665 1 - by flanking markers 2 136916935 213594495 1 - by flanking markers 1359023 rat Bp272 Blood pressure QTL 272 6 2.5 37142 D6Rat80 42778 D6Rat171 37142 D6Rat80 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure hypertension 625381 11882571 6 1111498 38512233 1 - by flanking markers 6 1301952 27253998 1 - by flanking markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 6 1120393 28706721 1 - by flanking markers 6 16536140 27261739 1 - by flanking markers 1359030 rat Bp277 Blood pressure QTL 277 2 38362 D2Rat161 10712 D2Mgh10 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure hypertension 629618 12209022 2 138120195 219929405 1 - by flanking markers 2 118264490 163264490 4 - by one flank marker only 1358992 SHR.WKY-(D2Rat40-D2Rat50) 2 118446646 200453484 1 - by flanking markers 2 114837527 185876470 1 - by flanking markers 1359031 rat Bp275 Blood pressure QTL 275 2 10712 D2Mgh10 35849 D2Rat62 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 629618 12209022 2 219929245 254867363 1 - by flanking markers 2 183664122 228664122 4 - by one flank marker only 1359001 WKY.SHR-(D2Rat42-D2Rat139) 2 200453324 236318668 1 - by flanking markers 2 185876309 219753474 1 - by flanking markers 1359032 rat Hrtrt18 Heart rate QTL 18 2 36213 D2Rat40 36773 D2Rat50 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;decreased heart rate Bradycardia;heart disease 629618 12209022 2 189197858 227035367 1 - by flanking markers 2 163154227 200390471 1 - by flanking markers 1358992 SHR.WKY-(D2Rat40-D2Rat50) 2 169852670 207612467 1 - by flanking markers 2 157142078 192625452 1 - by flanking markers 1359033 rat Bp273 Blood pressure QTL 273 8 33559 D8Mit5 34415 D8Mgh6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal touch/ nociception;decreased systemic arterial blood pressure hypertension 1358955 12388796 2345;2347;2351 Chrna3;Chrna5;Chrnb4 8 33603024 65467051 1 - by flanking markers 8 32203394 64762616 1 - by flanking markers 61106 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv 8 33558660 65717592 1 - by flanking markers 8 30848154 61290444 1 - by flanking markers 1359034 rat Bp274 Blood pressure QTL 274 2 35643 D2Rat21 35148 D2Rat27 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 629618 12209022 2 95410090 116297798 1 - by flanking markers 2 75806326 96482076 1 - by flanking markers 1358999 WKY.SHR-(D2Rat174-D2Rat28) 2 75687495 96556760 1 - by flanking markers 2 74786664 94359546 1 - by flanking markers 1359035 rat Bp276 Blood pressure QTL 276 2 38362 D2Rat161 34005 D2Mit8 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure hypertension 629618 12209022 2 138120195 169047413 1 - by flanking markers 2 118264490 148790758 1 - by flanking markers 1359006 WKY.SHR-(D2Rat27-D2Rat243) 2 118446646 149614623 1 - by flanking markers 2 114837527 143657569 1 - by flanking markers 1549827 rat Scl46 Serum cholesterol level QTL 46 4 3.5 42147 D4Arb15 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 4 198947905 243947905 5 - by peak with adj size 4 135601855 180601855 5 - by peak with adj size 1302711 1549801 ExHC/Seac BN/Seac 4 131864442 176864442 5 - by peak with adj size 4 132396220 177396220 5 - by peak with adj size 1549828 rat Bp258 Blood pressure QTL 258 2 0.03 1358052 D2Chm90 1358031 D2Chm225 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1357413;1599557;7421500;7421631 15738349;17143582;23814039;19461651 Bp310 (interacts with);Bp346 (interacts with);Bp368 (sub_region) 2 167706439 177627084 1 - by flanking markers 2 147424195 156267340 1 - by flanking markers 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd 2 148295267 158268703 1 - by flanking markers 2 142323368 150650069 1 - by flanking markers 1549829 rat Scl48 Serum cholesterol level QTL 48 12 5.0 37830 D12Rat36 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 12 16892812 54450796 5 - by peak with adj size 12 10716230 46782294 5 - by peak with adj size 1302711 1549801 ExHC/Seac BN/Seac 12 15021986 52716770 5 - by peak with adj size 12 9603277 46669029 5 - by peak with adj size 1549830 rat Bss1 Bone structure and strength QTL 1 1 4.8 40534 D1Rat291 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) abnormal bone strength bone disease 1549683 16059631 1 197197749 242197749 5 - by peak with adj size 1 177666790 222666790 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 1 190282646 235282646 5 - by peak with adj size 1 172609619 217609619 5 - by peak with adj size 1549831 rat Bss6 Bone structure and strength QTL 6 10 4.0 41170 D10Rat146 lumbar vertebra strength trait (VT:0010574) vertebra ultimate force (CMO:0001678) abnormal bone strength bone disease 1549683 16059631 10 60260619 105260619 5 - by peak with adj size 10 61314296 106314296 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 10 60450007 105450007 5 - by peak with adj size 10 57576521 102576521 5 - by peak with adj size 1549832 rat Bss3 Bone structure and strength QTL 3 4 11.0 35070 D4Rat57 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure bone disease 1549683 16059631 4 174127594 219127594 5 - by peak with adj size 4 112039347 157039347 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 4 109636356 154636356 5 - by peak with adj size 4 109827074 154827074 5 - by peak with adj size 1549833 rat Bp257 Blood pressure QTL 257 2 0.003 2613 Fgg 1358039 D2Chm57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1357413;1599557;7421500;7421631 15738349;17143582;23814039;19461651 Bp279 (interacts with);Bp310 (interacts with);Bp363 (sub_region);Bp364 (sub_region);Bp365 (sub_region) 2 201401700 219177325 1 - by flanking markers 2 174727312 192363025 1 - by flanking markers 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd 2 181987080 199696953 1 - by flanking markers 2 168354880 185122374 1 - by flanking markers 1549834 rat Scl45 Serum cholesterol level QTL 45 14 5.8 41406 D14Rat88 40140 D14Rat95 38070 D14Rat43 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851;2300117 16061941;18753676 Scl59 (sub_region) 14 65509916 104803539 1 - by flanking markers 14 66611911 101647208 1 - by flanking markers 1302711 1549801 ExHC/Seac BN/Seac 14 51818462 105074364 2 - by one flank and peak markers 14 50023211 95023211 4 - by one flank marker only 1549835 rat Tcas7 Tongue tumor susceptibility QTL 7 19 0.001 11472 D19Wox8 10418 D19Mit6 tongue integrity trait (VT:0010553) squamous cell carcinoma of the head and neck tumor number (CMO:0001876) increased tongue tumor incidence Tongue Neoplasms 1358147 15876484 Tcas1 (sub_region) 19 35433730 54715514 1 - by flanking markers 19 26536747 41612881 1 - by flanking markers 1358921 WF.DA-(D19Mit1-D19Mit6)/Kop 19 24455726 43907843 1 - by flanking markers 19 24817978 39654489 1 - by flanking markers 1549836 rat Bss2 Bone structure and strength QTL 2 2 7.5 34864 D2Rat67 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone strength;abnormal bone structure bone disease 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 1549837 rat Hcar15 Hepatocarcinoma resistance QTL 15 1 0.05 34074 D1Mgh8 10674 D1Mgh12 36866 D1Rat73 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased apoptosis;decreased hepatoma incidence;decreased liver tumor incidence Experimental Liver Neoplasms 1358145 15771619 1 169999389 270717037 1 - by flanking markers 1 156124624 247322277 1 - by flanking markers 2304125 DRH.F344-(D1Mgh8-D1Mgh12)/Shigm 1 163796316 282763074 2 - by one flank and peak markers 1 153136852 260522016 2 - by one flank and peak markers 1549838 rat Bss4 Bone structure and strength QTL 4 5 9.2 35060 D5Rat29 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone strength;abnormal bone structure bone disease 1549683 16059631 3001 Lepr 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 1549839 rat Bw52 Body weight QTL 52 4 1.0E-4 43802 D4Got41 3811 Tacr1 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight obesity 1358143 15833945 628871 Gimap5 4 60179409 178095041 1 - by flanking markers 4 60262965 116780394 1 - by flanking markers 1357980 BB.SHR-(D4Got41-Tacr1)/K 4 60439127 113416139 1 - by flanking markers 4 61697658 115089733 1 - by flanking markers 1549840 rat Bss5 Bone structure and strength QTL 5 7 9.8 37236 D7Rat51 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure bone disease 1549683 16059631 7 32058288 77058288 5 - by peak with adj size 7 28333735 73333735 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 7 32035053 77035053 5 - by peak with adj size 7 24751841 69751841 5 - by peak with adj size 1549841 rat Bp256 Blood pressure QTL 256 2 0.03 1358030 D2Chm33 1358052 D2Chm90 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1357413;1599557;7421500;7421631 15738349;17143582;23814039;19461651 Bp279 (interacts with);Bp310 (interacts with);Bp345 (interacts with);Bp367 (sub_region) 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 1549842 rat Bp248 Blood pressure QTL 248 16 0.01 36892 D16Rat12 1358042 D16Chm66 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1300037 15080379 Bp75 (sub_region) 16 1084304 3406223 1 - by flanking markers 16 350121 3080985 1 - by flanking markers 1358168 SS.LEW-(D16Mit2-D16Chm23)/Ayd 16 1090054 3439762 1 - by flanking markers 16 380245 2995463 1 - by flanking markers 1549843 rat Bw53 Body weight QTL 53 4 1.0E-4 43802 D4Got41 2590 Fabp1 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight obesity 1358143 15833945 628871 Gimap5 4 60179409 163844105 1 - by flanking markers 4 60262965 104415981 1 - by flanking markers 1358922 BB.WOKW-(D4Got41-Fabp1)/K 4 60439127 99066957 1 - by flanking markers 4 61697658 103194791 1 - by flanking markers 1549844 rat Bss7 Bone structure and strength QTL 7 15 6.4 40516 D15Rat106 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure bone disease 1549683 16059631 15 87444850 114627140 5 - by peak with adj size 15 83677810 109758846 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 15 84050550 111246239 5 - by peak with adj size 15 75788062 101769107 5 - by peak with adj size 1549845 rat Scl44 Serum cholesterol level QTL 44 5 6.0 41350 D5Rat132 36275 D5Rat57 37950 D5Rat95 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 5 45401839 158499076 1 - by flanking markers 5 41498818 155121024 1 - by flanking markers 1302711 1549801 ExHC/Seac BN/Seac 5 40777918 154732375 1 - by flanking markers 5 40128307 148607290 1 - by flanking markers 1549846 rat Scl47 Serum cholesterol level QTL 47 10 3.6 36751 D10Rat25 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 10 52002683 97002683 5 - by peak with adj size 10 54091148 99091148 5 - by peak with adj size 1302711 1549801 ExHC/Seac BN/Seac 10 53104718 98104718 5 - by peak with adj size 10 50574707 95574707 5 - by peak with adj size 1549847 rat Bss8 Bone structure and strength QTL 8 19 4.0 38432 D19Rat32 lumbar vertebra strength trait (VT:0010574) vertebra ultimate force (CMO:0001678) abnormal bone strength bone disease 1549683 16059631 19 1 32364000 5 - by peak with adj size 19 1 32421352 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 19 1 32379055 5 - by peak with adj size 19 1 31963836 5 - by peak with adj size 1549848 rat Bvd6 Brain ventricular dilatation QTL 6 11 3.1 1.0E-4 4.5 39084 D11Rat93 41692 D11Rat89 37942 D11Rat46 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) hydrocephaly hydrocephalus 68693;68196 11178739;11178739 3761 Sst Bvd3 (sub_region) 11 72432813 89414405 1 - by flanking markers 11 67930910 87759784 2 - by one flank and peak markers 60994 68189 F344 HTX/Hcj 11 69342319 86312439 1 - by flanking markers 11 66113321 82169223 1 - by flanking markers 1549897 rat Stresp12 Stress response QTL 12 13 3.35 3.4 38396 D13Rat77 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 additive 13 48547327 93547327 5 - by peak with adj size 13 40675437 85675437 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 13 43575717 88575717 5 - by peak with adj size 13 38433408 83433408 5 - by peak with adj size 1549898 rat Neuinf3 Neuroinflammation QTL 3 10 26.4 59985 D10Got6 33591 D10Mit14 34361 D10Mgh25 nervous system integrity trait (VT:0010566) MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980) abnormal level of surface class II molecules autoimmune disease of the nervous system 1358146;1358788 15821736;14586010 619813 Ciita additive Neuinf2 (sub_region) 10 1728277 4281241 1 - by flanking markers 10 3219701 5339859 1 - by flanking markers 737658 737950 PVG.1AV1 DA/Ztm 10 2847625 5460218 1 - by flanking markers 10 3406320 5387112 1 - by flanking markers 1549899 rat Stresp8 Stress response QTL 8 7 4.37 8.0E-4 0.5 37360 D7Rat68 stress-related behavior trait (VT:0010451) defensive burying duration (CMO:0001961) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 7 100168740 143501887 5 - by peak with adj size 7 97285400 142285400 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 7 100192194 145192194 5 - by peak with adj size 7 90482196 135012528 5 - by peak with adj size 1549900 rat Iddm20 Insulin dependent diabetes mellitus QTL 20 17 3.7 38992 D17Rat61 40000 D17Rat115 pancreas integrity trait (VT:0010560) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) autoimmune response;hyperglycemia Experimental Diabetes Mellitus 1358924;2313174 15793267;19720792 3796 Syk incomplete_dominance 17 16076494 25280219 1 - by flanking markers 17 19877005 27819082 1 - by flanking markers 1304487 1359010 BBDR/Wor WF.BBDR-ART2a/Wor 17 14009679 23316697 1 - by flanking markers 17 13986773 21975515 1 - by flanking markers 1549901 rat Neudeg2 Neurodegradation QTL 2 5 4.0 0.0 39160 D5Rat73 38548 D5Rat82 39186 D5Rat70 nervous system integrity trait (VT:0010566) mononuclear cell count (CMO:0002119) decreased motor neuron number;increased double-negative T cell number central nervous system disease;neurodegenerative disease 1358788;1358768;2317162 14586010;15894332;19526058 additive Neudeg1 (interacts with) 5 29676862 49366257 1 - by flanking markers 5 25602274 45822846 1 - by flanking markers 629486 737950 PVG/OlaHsd DA/Ztm 5 24956212 44747071 1 - by flanking markers 5 24838710 44045280 1 - by flanking markers 1549902 rat Bp269 Blood pressure QTL 269 12 41962 D12Arb6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial diastolic blood pressure hypertension 1358144 15809361 12 20650729 54450796 5 - by peak with adj size 12 14356765 46782294 5 - by peak with adj size 69369 631576 SS LEW/CrlCrlj 12 18752593 52716770 5 - by peak with adj size 12 13182736 46669029 5 - by peak with adj size 1549903 rat Bp267 Blood pressure QTL 267 1 10333 D1Arb33 34381 D1Mgh7 36765 D1Rat27 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial diastolic blood pressure;increased systemic arterial systolic blood pressure hypertension 1358144 15809361 3175;1306420 Klk1b3;Klk7 1 80380367 114601028 1 - by flanking markers 1 77541583 106445306 1 - by flanking markers 69369 631576 SS LEW/CrlCrlj 1 79134941 113593716 1 - by flanking markers 1 77876254 106047988 1 - by flanking markers 1549904 rat Neuinf1 Neuroinflammation QTL 1 5 3.0 0.0 41492 D5Rat178 41798 D5Rat246 35823 D5Rat50 nervous system integrity trait (VT:0010566) blood T lymphocyte count (CMO:0000110) increased double-negative T cell number central nervous system disease 1358788;1358768 14586010;15894332 additive 5 164789054 177180328 2 - by one flank and peak markers 5 161449395 173096209 4 - by one flank marker only 629486 737950 PVG/OlaHsd DA/Ztm 5 161084664 173707219 2 - by one flank and peak markers 5 154828214 166875058 2 - by one flank and peak markers 1549905 rat Stresp10 Stress response QTL 10 6 6.83 0.0066 2.7 35963 D6Rat46 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 Bp141 (maps to same region);Despr12 (maps to same region) 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 1549907 rat Neuinf2 Neuroinflammation QTL 2 10 27.0 0.0 37464 D10Rat95 38062 D10Rat96 nervous system integrity trait (VT:0010566) MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980) abnormal level of surface class II molecules Experimental Autoimmune Encephalomyelitis;autoimmune disease of the nervous system 1358146;1358788;1358768;7242893 15821736;14586010;15894332;18292553 additive Neuinf3 (sub_region) 10 5044836 5243736 1 - by flanking markers 10 6172805 6380753 1 - by flanking markers 629486 737950 PVG/OlaHsd DA/Ztm 10 6229289 6429075 1 - by flanking markers 10 6154377 6357896 1 - by flanking markers 1549908 rat Neudeg1 Neurodegradation QTL 1 8 5.5 0.0 37742 D8Rat163 40736 D8Rat129 41794 D8Rat205 nervous system integrity trait (VT:0010566) logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986) decreased motor neuron number;motor neuron degeneration neurodegenerative disease 1358768;1358788;2317162 15894332;14586010;19526058 additive Neudeg2 (interacts with) 8 32911182 100850022 1 - by flanking markers 8 31508524 98947320 1 - by flanking markers 629486 737950 PVG/OlaHsd DA/Ztm 8 32888352 101374135 1 - by flanking markers 8 30188867 94457446 1 - by flanking markers 1549909 rat Stresp11 Stress response QTL 11 8 6.83 0.0019 2.1 37818 D8Rat66 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 Activ1 (maps to same region) 8 80157100 125157100 5 - by peak with adj size 8 78008525 123008525 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 8 80697934 125697934 5 - by peak with adj size 8 73473045 118473045 5 - by peak with adj size 1549910 rat Bw54 Body weight QTL 54 1 0.05 37356 D1Rat225 35457 D1Rat90 body mass (VT:0001259) body weight (CMO:0000012) abnormal fat pad morphology;increased body weight obesity 1358859 15883013 3360 Pnlip additive Bw115 (maps to same region);Niddm24 (maps to same region) 1 283061367 289137268 1 - by flanking markers 1 261180160 267111153 1 - by flanking markers 1358995 F344.OLETF-(D1Rat166-D1Rat90)/Tj 1 236795785 281795785 4 - by one flank marker only 1 214647894 259647894 4 - by one flank marker only 1549911 rat Stresp9 Stress response QTL 9 1 6.13 0.0035 1.7 39116 D1Rat145 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1549912 rat Bp268 Blood pressure QTL 268 10 41962 D12Arb6 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure;increased systemic arterial systolic blood pressure hypertension 1358144;1625680 15809361;17460389 12 20650729 54450796 5 - by peak with adj size 12 14356765 46782294 5 - by peak with adj size 69369 631576 SS LEW/CrlCrlj 12 18752593 52716770 5 - by peak with adj size 12 13182736 46669029 5 - by peak with adj size 1549913 rat Stresp13 Stress response QTL 13 2 4.56 0.0011 1.8 39914 D2Rat188 stress-related behavior trait (VT:0010451) post-insult time to onset of defensive burying response (CMO:0001962) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 Despr1 (maps to same region) 1 122414658 167414658 5 - by peak with adj size 2 1 23400664 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1554317 rat Bmd4 Bone mineral density QTL 4 10 9.4 1.0E-4 35386 D10Rat8 36249 D10Rat45 36886 D10Rat32 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896;2316850 16180139;19841953 2161;2711;2920;3926;620677;620826;621140;621625;708568;1307023;1307496;1307522;1359691 Asgr2;Slc2a4;Irf1;Ube2i;Ltc4s;Akap1;G3bp1;Aurkb;Rabep1;Rhot1;Plxdc1;Rnps1;Rflnb 10 20046466 102560630 1 - by flanking markers 10 20233281 104013574 1 - by flanking markers 60994 60999 F344 LEW 10 20170031 102897474 1 - by flanking markers 10 19816042 99406971 1 - by flanking markers 1554318 rat Bmd5 Bone mineral density QTL 5 19 12.1 1.0E-4 35547 D19Rat25 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896 16180139 19 20855340 65855340 5 - by peak with adj size 19 8121935 53121935 5 - by peak with adj size 60994 60999 F344 LEW 1554319 rat Bmd2 Bone mineral density QTL 2 2 13.4 1.0E-4 35613 D2Rat59 38362 D2Rat161 38584 D2Rat91 lumbar vertebra area (VT:0010570) lumbar vertebra cross-sectional area (CMO:0001689) increased bone mineral density osteoporosis 1553896 16180139 2 138120342 247933461 1 - by flanking markers 2 118264840 221131552 1 - by flanking markers 60994 60999 F344 LEW 2 118446793 228582621 1 - by flanking markers 2 114837675 212549332 1 - by flanking markers 1554320 rat Bmd1 Bone mineral density QTL 1 1 12.2 1.0E-4 41498 D1Rat266 41058 D1Rat245 38782 D1Rat136 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896;2293187 16180139;17907919 Bmd10 (interacts with);Bmd15 (interacts with) 1 249747 89565657 2 - by one flank and peak markers 1 390736 74903688 2 - by one flank and peak markers 60994 60999 F344 LEW 1 254393 86904217 2 - by one flank and peak markers 1 509108 86060548 2 - by one flank and peak markers 1554321 rat Bmd3 Bone mineral density QTL 3 8 7.9 1.0E-4 36934 D8Rat10 37580 D8Rat99 35018 D8Rat15 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896 16180139 8 61081077 117431943 1 - by flanking markers 8 43561064 129041809 2 - by one flank and peak markers 60994 60999 F344 LEW 8 44458129 118087517 1 - by flanking markers 8 40952565 123900184 2 - by one flank and peak markers 1556747 rat Calcic1 Intracellular calcium level QTL 1 12 3.6 19.8 34729 D12Mgh5 34373 D12Mgh6 2174 Atp2a2 platelet calcium amount (VT:0010500) platelet intracellular calcium level (CMO:0000922) hypertension 1547855 15882549 2174 Atp2a2 12 33647399 49270175 2 - by one flank and peak markers 12 29130180 42387195 1 - by flanking markers 631604 1556748 SHR/Snk F344/Snk 12 31723565 47433663 2 - by one flank and peak markers 12 28064433 40130419 2 - by one flank and peak markers 1558640 rat Prcs2 Prostate cancer susceptibility QTL 2 20 3.3 37594 D20Rat41 35657 D20Rat5 34872 D20Rat3 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hyperplasia Prostatic Neoplasms 1358944 15805257 69328 Cdkn1a dominant 20 6118659 21025734 1 - by flanking markers 20 4740609 18411969 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 20 4039113 18872273 1 - by flanking markers 20 4606607 17617956 1 - by flanking markers 1558641 rat Cm47 Cardiac mass QTL 47 6 2.9 0.001 34126 D6Mgh4 33977 D6Mit4 34306 D6Mgh5 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 6 70194178 117391806 1 - by flanking markers 6 59946874 108503674 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 6 60606431 108154445 1 - by flanking markers 6 57730540 104085867 1 - by flanking markers 1558642 rat Prcr2 Prostate cancer resistance QTL 2 1 4.3 38028 D1Rat121 38134 D15Rat45 37974 D1Rat211 prostate integrity trait (VT:0010571) area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hypoplasia Prostatic Neoplasms 1358944 15805257 1 23292314 45739646 1 - by flanking markers 1 21288064 38490502 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 1 21812623 44409802 1 - by flanking markers 1 20763158 44095856 1 - by flanking markers 1558643 rat Cm44 Cardiac mass QTL 44 10 4.8 3.68E-5 34445 D10Mgh6 34128 D10Mgh1 3177 Ngfr heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw57 (maps to same region) 10 63366082 103048942 2 - by one flank and peak markers 10 67677924 100865886 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 64648175 102149713 2 - by one flank and peak markers 10 61345276 99703528 2 - by one flank and peak markers 1558644 rat Cm45 Cardiac mass QTL 45 13 3.6 0.002 11375 D13Arb8 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 13 34129640 79129640 5 - by peak with adj size 13 25198204 70198204 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 13 29076934 74076934 5 - by peak with adj size 13 23692969 68692969 5 - by peak with adj size 1558645 rat Bw55 Body weight QTL 55 1 3.2 0.004 621323 Phox2a body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 Bw59 (maps to same region) 1 150585707 195585707 5 - by peak with adj size 1 136792830 181792830 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 1 144395993 189395993 5 - by peak with adj size 1 133680936 178680936 5 - by peak with adj size 1558646 rat Swd5 Spike wave discharge measurement QTL 5 8 3.45 3.6E-4 12.0 44394 D8Got49 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge frequency (CMO:0001742) absence seizures childhood absence epilepsy 1553898 15030491 8 17667379 62667379 5 - by peak with adj size 8 16442230 61442230 5 - by peak with adj size 1354669 1554304 BN/OrlIcoCrlf GAERS/Mave 8 17666555 62666555 5 - by peak with adj size 8 14906751 59906751 5 - by peak with adj size 1558647 rat Cm46 Cardiac mass QTL 46 3 5.4 5.5E-6 33862 D3Mit9 34347 D3Mgh16 34198 D3Mgh8 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw56 (maps to same region);Cm43 (maps to same region);Cm48 (maps to same region) 3 11361817 39535971 1 - by flanking markers 3 6373454 26674018 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000866 34394121 1 - by flanking markers 3 10778823 30356773 1 - by flanking markers 1558648 rat Smcn1 Smooth muscle cell number QTL 1 2 0.039 3407 Prlr 40466 D2Rat303 blood vessel smooth muscle cell quantity (VT:0010525) aorta smooth muscle cell count per unit vessel length (CMO:0001646) vascular smooth muscle hyperplasia aortic disease 1357419 15741507 2071 Agtr1b 2 84360850 155130826 1 - by flanking markers 2 59507966 131522430 1 - by flanking markers 1357978 SS.MNS-(D2Mit6-D2Rat303)/Ayd 2 60131410 135646395 1 - by flanking markers 2 59134147 127460910 1 - by flanking markers 1558649 rat Bw58 Body weight QTL 58 18 3.4 5.0E-4 34290 D18Mgh4 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 18 56512589 87229863 5 - by peak with adj size 18 57085070 87265094 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 18 57448678 88201929 5 - by peak with adj size 1558650 rat Cm48 Cardiac mass QTL 48 3 4.0 1.0E-4 33862 D3Mit9 34347 D3Mgh16 34347 D3Mgh16 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw56 (maps to same region);Cm43 (maps to same region);Cm46 (maps to same region) 3 11361817 39535971 1 - by flanking markers 3 6373454 26674018 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 3 6000866 34394121 1 - by flanking markers 3 10778823 30356773 1 - by flanking markers 1558651 rat Swd3 Spike wave discharge measurement QTL 3 4 4.62 2.4E-5 13.7 43803 D4Got39 60456 D4Got74 10144 D4Mgh16 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge frequency (CMO:0001742) absence seizures childhood absence epilepsy 1553898 15030491 4 56868238 157791280 1 - by flanking markers 4 56704868 91916048 1 - by flanking markers 1354669 1554304 BN/OrlIcoCrlf GAERS/Mave 4 57101077 92990863 1 - by flanking markers 4 58432133 92991462 1 - by flanking markers 1558652 rat Bw57 Body weight QTL 57 10 4.2 8.0E-4 2493 Ace 34128 D10Mgh1 67318 D10Arb12 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311;2312611 16097372;19697080 Bw87 (maps to same region);Cm44 (maps to same region) 10 92325331 93965127 2 - by one flank and peak markers 10 93730129 95381455 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 94170766 112626471 4 - by one flank marker only 10 89327017 90930437 2 - by one flank and peak markers 1558653 rat Prcr1 Prostate cancer resistance QTL 1 2 5.0 20.3 36093 D2Rat26 36213 D2Rat40 38362 D2Rat161 prostate integrity trait (VT:0010571) area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hypoplasia Prostatic Neoplasms 1358944 15805257 3098 Mme dominant 2 113748813 189197988 1 - by flanking markers 2 73374972 163154358 2 - by one flank and peak markers 737892 1547866 ACI/SegHsd F344/Jcl 2 93995316 169852800 1 - by flanking markers 2 72532993 157142209 2 - by one flank and peak markers 1558654 rat Bw56 Body weight QTL 56 3 4.5 1.71E-5 34347 D3Mgh16 33862 D3Mit9 34347 D3Mgh16 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 Cm43 (maps to same region);Cm46 (maps to same region);Cm48 (maps to same region) 3 11361699 39536215 1 - by flanking markers 3 6373335 26674263 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000748 34394365 1 - by flanking markers 3 10778704 30357018 1 - by flanking markers 1558655 rat Swd4 Spike wave discharge measurement QTL 4 7 3.68 2.0E-4 12.0 34511 D7Mgh5 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge severity grade (CMO:0001988) absence seizures childhood absence epilepsy 1553898 15030491 7 96625708 141625708 5 - by peak with adj size 7 93320292 138320292 5 - by peak with adj size 1354669 1554304 BN/OrlIcoCrlf GAERS/Mave 7 96630946 141630946 5 - by peak with adj size 7 86983365 131983365 5 - by peak with adj size 1558656 rat Prcs1 Prostate cancer susceptibility QTL 1 19 5.0 17.6 38032 D19Rat101 39212 D19Rat46 40998 D19Rat75 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hyperplasia Prostatic Neoplasms 1358944 15805257 19 27017884 49665957 1 - by flanking markers 19 16245310 36472155 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 19 15939528 38798459 1 - by flanking markers 19 15114598 34521833 1 - by flanking markers 1558657 rat Cm43 Cardiac mass QTL 43 3 6.6 2.93E-8 33862 D3Mit9 34347 D3Mgh16 34198 D3Mgh8 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw56 (maps to same region);Cm46 (maps to same region);Cm48 (maps to same region) 3 11361817 39535971 1 - by flanking markers 3 6373454 26674018 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000866 34394121 1 - by flanking markers 3 10778823 30356773 1 - by flanking markers 1558658 rat Bw59 Body weight QTL 59 1 3.5 3.0E-4 36580 D1Rat112 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 Bw55 (maps to same region) 1 203609197 248609197 5 - by peak with adj size 1 184074275 229074275 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 1 196738546 241738546 5 - by peak with adj size 1 178784622 223784622 5 - by peak with adj size 1558659 rat Tescar1 Testicular tumor resistance QTL 1 11 3.9 39504 D11Rat88 39084 D11Rat93 testis integrity trait (VT:0010572) percentage of study population developing testis tumors during a period of time (CMO:0001261) increased testis tumor incidence Testicular Neoplasms 1358944 15805257 11 324296 72433053 1 - by flanking markers 11 597138 67931151 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 11 325031 69342559 1 - by flanking markers 11 1041931 66113562 1 - by flanking markers 1559055 rat Bp278 Blood pressure QTL 278 17 0.04 38706 D17Rat84 12903975 D17Chm71 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1547847;1601352;1599557 15632271;17420333;17143582 17 23473207 68473207 4 - by one flank marker only 17 29603712 72799224 1 - by flanking markers 1559033 1559035 SS.LEW-(D17Rat65-Prl)/Ayd SS.LEW-(D17Chm14-D17Rat181)/Ayd 17 21490950 66490950 4 - by one flank marker only 17 23653184 68653184 4 - by one flank marker only 1559282 rat Emca5 Estrogen-induced mammary cancer QTL 5 3 3.9 41780 D3Rat227 40440 D3Rat210 37980 D3Rat114 mammary gland integrity trait (VT:0010552) percentage of study population developing mammary tumors during a period of time (CMO:0000948) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 dominant 3 50522686 183740530 2 - by one flank and peak markers 3 41054012 171063335 2 - by one flank and peak markers 10008 737892 BN/SsNHsd ACI/SegHsd 3 45406058 177699992 2 - by one flank and peak markers 3 43827364 169034231 2 - by one flank and peak markers 1559283 rat Emca4 Estrogen-induced mammary cancer QTL 4 7 3.7 34999 D7Rat44 36661 D7Rat15 35841 D7Rat19 mammary gland integrity trait (VT:0010552) percentage of study population developing mammary tumors during a period of time (CMO:0000948) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 dominant Emca8 (interacts with);Ept7 (maps to same region) 7 69590305 110975995 1 - by flanking markers 7 66201980 107428439 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 7 69399586 111043530 1 - by flanking markers 7 62004452 101773158 1 - by flanking markers 1576302 rat Schws4 Schwannoma susceptibility QTL 4 6 0.0078 42328 D6Rat218 5503130 NGB 33662 D6Mit1 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300;11556249 16003739;21427360 727780 Gpx2 6 96954540 120415502 2 - by one flank and peak markers 6 86446712 111234448 2 - by one flank and peak markers 1566454 1566456 BDIV/Zte BDIX/Zte 6 87418448 111129520 2 - by one flank and peak markers 6 83190345 106747639 2 - by one flank and peak markers 1576303 rat Ept7 Estrogen-induced pituitary tumorigenesis QTL 7 7 3.7 34999 D7Rat44 36661 D7Rat15 35841 D7Rat19 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1566582;1642526;8662361;1642522 17876666;24448715;16885383 3130;3904;621120 Myc;Trhr;Cdk4 recessive Emca4 (maps to same region) 7 69590305 110975995 1 - by flanking markers 7 66201980 107428439 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 7 69399586 111043530 1 - by flanking markers 7 62004452 101773158 1 - by flanking markers 1576304 rat Schws7 Schwannoma susceptibility QTL 7 10 0.0115 44670 D10Got1 36249 D10Rat45 34254 D10Mgh12 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300;11554205 16003739;26530423 10 3662335 20046466 1 - by flanking markers 10 4697541 20233281 1 - by flanking markers 1566454 1566456 BDIV/Zte BDIX/Zte 10 4835638 20170031 1 - by flanking markers 11554329 BDIX.BDIV-D10Got1-D10Rat45/Zte 10 4765527 19816042 1 - by flanking markers 1576305 rat Emca6 Estrogen-induced mammary cancer QTL 6 4 5.8 35625 D4Rat14 40322 D4Rat202 38262 D4Rat103 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 recessive Ept5 (maps to same region) 4 44024230 222493466 1 - by flanking markers 4 41729583 159115617 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 4 43414605 155469929 1 - by flanking markers 4 44463720 155883716 1 - by flanking markers 1576306 rat Schws3 Schwannoma susceptibility QTL 3 3 0.001 33810 D3Mit2 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300 16003739 3 132251620 177251620 5 - by peak with adj size 3 120714678 165714678 5 - by peak with adj size 1566454 1566456 BDIV/Zte BDIX/Zte 3 125848628 170848628 5 - by peak with adj size 3 118839124 163839124 5 - by peak with adj size 1576307 rat Cia28 Collagen induced arthritis QTL 28 10 35256 D10Rat11 61275 D10Arb22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) Experimental Arthritis 1359065;1642451;2307198 15944295;17673937;18540828 10 99184058 107484761 1 - by flanking markers 10 100633512 110718848 4 - by one flank marker only 1299877 DA.F344-(D10Rat204-D10Arb22)/Arb 10 99492217 107857673 1 - by flanking markers 10 96120911 104060283 1 - by flanking markers 1576308 rat Schws1 Schwannoma susceptibility QTL 1 10 0.0041 34053 D10Mit3 34202 D10Mgh16 10662 D10Wox23 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300;11554205 16003739;26530423 10 41091453 105757970 1 - by flanking markers 10 41339689 107260629 1 - by flanking markers 1566454 1566456 BDIV/Zte BDIX/Zte 10 41260363 106105607 1 - by flanking markers 11554327 BDIX.BDIV-D10Mit3-D10Mgh16/Zte 10 40035094 102359817 1 - by flanking markers 1576309 rat Emca7 Estrogen-induced mammary cancer QTL 7 6 4.0 39190 D6Rat68 38390 D6Rat81 35140 D6Rat22 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 dominant Emca2 (interacts with) 6 2516723 120995129 1 - by flanking markers 6 2802670 111967837 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 6 2537030 111715717 1 - by flanking markers 6 15107216 107351382 1 - by flanking markers 1576310 rat Schws2 Schwannoma susceptibility QTL 2 1 0.029 33646 D1Mit4 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300 16003739 1566454 1566456 BDIV/Zte BDIX/Zte 1576311 rat Pia26 Pristane induced arthritis QTL 26 10 33565 D10Mit9 35513 D10Rat24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis;Experimental Arthritis 1359065;2300006;2302383;1358860;2307198 15944295;18706093;18668563;15641042;18540828 3612;3965;1307740;1308885;1309749 Ncor1;Trpv2;Natd1;Trim41;Trim16 10 31740635 78195122 1 - by flanking markers 10 31931622 79229233 1 - by flanking markers 1358990 DA.F344-(D10Mit9-D10Rat24)/Nsi 10 31919397 78343192 1 - by flanking markers 10 31224026 75632053 1 - by flanking markers 1576312 rat Emca8 Estrogen-induced mammary cancer QTL 8 5 4.1 39722 D5Rat134 35651 D5Rat37 37950 D5Rat95 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885;7364727 16885383;18057545;23151807 dominant Emca1 (maps to same region);Emca4 (interacts with) 5 55977668 151220567 1 - by flanking markers 5 52434178 148460381 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 5 51418671 147487820 1 - by flanking markers 5 50328551 141643988 1 - by flanking markers 1576313 rat Pia25 Pristane induced arthritis QTL 25 10 35256 D10Rat11 61275 D10Arb22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) Experimental Arthritis 1359065 15944295 10 99184058 107484761 1 - by flanking markers 10 100633512 110718848 4 - by one flank marker only 1299877 DA.F344-(D10Rat204-D10Arb22)/Arb 10 99492217 107857673 1 - by flanking markers 10 96120911 104060283 1 - by flanking markers 1576314 rat Eutr1 Estrogen induced uterine response QTL 1 5 38744 D5Rat116 36811 D5Rat16 36558 D5Rat19 uterus integrity trait (VT:0010575) pyometritis severity score (CMO:0002009) reproductive system inflammation Inflammation;bacterial infectious disease 1559292 16284801 incomplete_dominance 5 1521341 82842091 1 - by flanking markers 5 1220773 79863911 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 5 1525098 78720537 1 - by flanking markers 5 2138965 166875058 2 - by one flank and peak markers 1576315 rat Schws6 Schwannoma susceptibility QTL 6 15 0.0069 34357 D15Mgh4 nervous system integrity trait (VT:0010566) post-insult time of death (CMO:0002005) increased incidence of induced tumors neurilemmoma 1559300 16003739 15 64956643 109956643 5 - by peak with adj size 15 60849424 105849424 5 - by peak with adj size 1566454 1566456 BDIV/Zte BDIX/Zte 15 61447766 106447766 5 - by peak with adj size 15 53806152 98806152 5 - by peak with adj size 1576316 rat Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 4 3.8 38262 D4Rat103 39414 D4Rat204 34174 D4Mgh7 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1566582;1642526;1642522 17876666;16885383 2688;3556;3849;3903;69062;621083;632283 Ghrhr;Ret;Tgfa;Trh;Cdkn1b;Ccnd2;Ghrl dominant Emca6 (maps to same region) 4 149135946 243120755 1 - by flanking markers 4 82700691 182307104 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 4 84475257 178931073 1 - by flanking markers 4 83428419 177635233 1 - by flanking markers 1576317 rat Eutr2 Estrogen induced uterine response QTL 2 5 0.01 36113 D5Rat1 34041 D5Mit5 uterus integrity trait (VT:0010575) pyometritis severity score (CMO:0002009) reproductive system inflammation Inflammation;bacterial infectious disease 1559291 16284802 5 39876314 112058005 1 - by flanking markers 5 35911094 109163425 1 - by flanking markers 1331830 F344.BN-(D5Rat1-D5Mit5)/Dlw 5 35225432 108092802 1 - by flanking markers 5 34730116 104251008 1 - by flanking markers 1576318 rat Schws5 Schwannoma susceptibility QTL 5 13 0.0351 42383 D13Rat191 nervous system integrity trait (VT:0010566) post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019) increased incidence of induced tumors neurilemmoma 1559300 16003739 13 72405088 117405088 5 - by peak with adj size 13 65464406 110464406 5 - by peak with adj size 1566454 1566456 BDIV/Zte BDIX/Zte 1576319 rat Cia29 Collagen induced arthritis QTL 29 10 36496 D10Rat37 10641 D10Wox22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) Experimental Arthritis 1359065 15944295 10 34910943 94240491 1 - by flanking markers 10 35131252 95695218 1 - by flanking markers 1359004 DA.F344-(D10Mit9-D10Rat11)/Nsi 10 35139424 80139424 4 - by one flank marker only 10 33973921 78973921 4 - by one flank marker only 1578646 rat Bmd18 Bone mineral density QTL 18 15 5.2 41564 D15Rat80 40516 D15Rat106 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307 16461031 15 30309351 109944957 1 - by flanking markers 15 25506124 106177917 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 15 26381041 106550657 1 - by flanking markers 15 22806240 98288169 1 - by flanking markers 1578647 rat Bmd17 Bone mineral density QTL 17 15 4.0 41564 D15Rat80 40516 D15Rat106 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 15 30309351 109944957 1 - by flanking markers 15 25506124 106177917 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 15 26381041 106550657 1 - by flanking markers 15 22806240 98288169 1 - by flanking markers 1578648 rat Bss11 Bone structure and strength QTL 11 2 4.7 38362 D2Rat161 39878 D2Rat242 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 2 138120195 247064731 1 - by flanking markers 2 118264490 220244597 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 2 118446646 227707979 1 - by flanking markers 2 114837527 211674221 1 - by flanking markers 1578649 rat Bmd8 Bone mineral density QTL 8 1 4.9 35891 D1Rat19 41498 D1Rat266 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307 16461031 1 50173150 95173150 4 - by one flank marker only 1 43872710 88872710 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 1 49578577 94578577 4 - by one flank marker only 1 49393172 94393172 4 - by one flank marker only 1578650 rat Bmd6 Bone mineral density QTL 6 1 12.2 41058 D1Rat245 38782 D1Rat136 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 1 249747 44907799 1 - by flanking markers 1 390736 37647484 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 254393 43579402 1 - by flanking markers 1 509108 43284926 1 - by flanking markers 1578651 rat Bmd7 Bone mineral density QTL 7 1 14.2 41058 D1Rat245 38782 D1Rat136 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307 16461031 1 249747 44907799 1 - by flanking markers 1 390736 37647484 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 254393 43579402 1 - by flanking markers 1 509108 43284926 1 - by flanking markers 1578652 rat Bmd15 Bone mineral density QTL 15 7 5.2 37262 D7Rat64 38198 D7Rat69 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307;2293187 16461031;17907919 Bmd1 (interacts with) 7 12857572 67991627 1 - by flanking markers 7 11379354 64612198 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 7 12687850 67801690 1 - by flanking markers 7 9866467 60460686 1 - by flanking markers 1578653 rat Vnigr3 Vascular neointimal growth QTL 3 3 3.1 11278 D3Arb12 artery morphology trait (VT:0002191) artery neointimal hyperplastic lesion area (CMO:0001414) artery occlusion;vascular smooth muscle hyperplasia Hyperplasia 1578306;2316923 16434542;20026763 3 144554463 183740530 5 - by peak with adj size 3 132947812 171063335 5 - by peak with adj size 10008 724574 BN/SsNHsd SHR/NHsd 3 138374177 177699992 5 - by peak with adj size 3 130656562 169034231 5 - by peak with adj size 1578654 rat Bss10 Bone structure and strength QTL 10 1 4.0 35891 D1Rat19 37092 D1Rat52 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 1 50173150 176864669 1 - by flanking markers 1 43872710 162735928 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 49578577 169852184 1 - by flanking markers 1 49393172 159356837 1 - by flanking markers 1578655 rat Bmd11 Bone mineral density QTL 11 4 11.0 41458 D4Rat153 41616 D4Rat193 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307;2300256 16461031;18728226 4 89422120 134422120 4 - by one flank marker only 4 93201451 138201451 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 24631874 69631874 4 - by one flank marker only 4 90850165 135850165 4 - by one flank marker only 1578656 rat Vnigr2 Vascular neointimal growth QTL 2 3 4.2 11278 D3Arb12 artery morphology trait (VT:0002191) lesioned artery residual lumen area (CMO:0001417) Hyperplasia 1578306 16434542 3 144554463 183740530 5 - by peak with adj size 3 132947812 171063335 5 - by peak with adj size 10008 724574 BN/SsNHsd SHR/NHsd 3 138374177 177699992 5 - by peak with adj size 3 130656562 169034231 5 - by peak with adj size 1578657 rat Bss12 Bone structure and strength QTL 12 4 8.9 37378 D4Rat123 39916 D4Rat175 femur morphology trait (VT:0000559) femoral neck cross-sectional area (CMO:0001697) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 120851785 165851785 4 - by one flank marker only 4 61483655 106483655 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 56092756 101092756 4 - by one flank marker only 4 60220938 105220938 4 - by one flank marker only 1578658 rat Bss13 Bone structure and strength QTL 13 4 8.0 37378 D4Rat123 39916 D4Rat175 femur strength trait (VT:0010010) femoral neck polar moment of inertia (CMO:0001670) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 120851785 165851785 4 - by one flank marker only 4 61483655 106483655 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 56092756 101092756 4 - by one flank marker only 4 60220938 105220938 4 - by one flank marker only 1578659 rat Tspe1 Trichinella spiralis expulsion QTL 1 9 4.8 11.0 34815 D9Rat16 35843 D9Rat13 35172 D9Rat19 parasite quantity (VT:0010441) logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024) decreased susceptibility to parasitic infection Nematode Infections;Parasitic Intestinal Diseases 1578305 16465509 2299;620123 Cd28;Icos 9 66570118 71564273 1 - by flanking markers 9 58516719 62957638 1 - by flanking markers 61111 1302627 DA/Slc F344/NSlc 9 66757444 71010122 1 - by flanking markers 9 61381434 65691299 1 - by flanking markers 1578660 rat Bss19 Bone structure and strength QTL 19 15 4.3 41564 D15Rat80 40516 D15Rat106 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307 16461031 15 30309351 109944957 1 - by flanking markers 15 25506124 106177917 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 15 26381041 106550657 1 - by flanking markers 15 22806240 98288169 1 - by flanking markers 1578661 rat Bss20 Bone structure and strength QTL 20 18 3.7 37578 D18Rat65 39278 D18Rat44 femur morphology trait (VT:0000559) femoral neck cross-sectional area (CMO:0001697) abnormal bone structure osteoporosis 1578307 16461031 18 15466312 86114102 1 - by flanking markers 18 12245097 86863412 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 18 15695872 87080053 1 - by flanking markers 18 11791518 83218561 1 - by flanking markers 1578662 rat Bss15 Bone structure and strength QTL 15 4 19.6 37378 D4Rat123 35070 D4Rat57 femur width (VT:1000666) femoral neck width (CMO:0001695) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 151627684 196627684 4 - by one flank marker only 4 89539438 134539438 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 87136446 132136446 4 - by one flank marker only 4 87327165 132327165 4 - by one flank marker only 1578663 rat Bss18 Bone structure and strength QTL 18 10 3.6 38542 D10Rat132 35254 D10Rat2 femur width (VT:1000666) femoral neck width (CMO:0001695) abnormal bone structure osteoporosis 1578307 16461031 10 99844504 110568670 1 - by flanking markers 10 101222719 110718848 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 10 100155035 110992275 1 - by flanking markers 10 96703043 107057807 1 - by flanking markers 1578664 rat Bmd9 Bone mineral QTL density 9 2 5.0 36912 D2Rat1 38950 D2Rat173 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 2 9324722 67988414 1 - by flanking markers 2 9670332 49013509 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 2 9444679 49615930 1 - by flanking markers 2 11852062 49003364 1 - by flanking markers 1578665 rat Bss16 Bone structure and strength QTL 16 6 4.4 38006 D6Rat69 35140 D6Rat22 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307 16461031 6 6120187 85538444 1 - by flanking markers 6 6265856 75462111 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 6 6161722 76002731 1 - by flanking markers 6 11735669 72593685 1 - by flanking markers 1578666 rat Vnigr1 Vascular neointimal growth QTL 1 3 4.6 41210 D3Rat145 36745 D3Rat1 11278 D3Arb12 artery morphology trait (VT:0002191) artery lumen area (CMO:0001409) Hyperplasia 1578306 16434542 3 162615336 180128021 1 - by flanking markers 3 151160532 170016653 1 - by flanking markers 10008 724574 BN/SsNHsd SHR/NHsd 3 156381661 176418101 1 - by flanking markers 3 149040888 168026850 1 - by flanking markers 1578667 rat Bss21 Bone structure and strength QTL 21 18 3.5 37578 D18Rat65 39278 D18Rat44 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 18 15466312 86114102 1 - by flanking markers 18 12245097 86863412 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 18 15695872 87080053 1 - by flanking markers 18 11791518 83218561 1 - by flanking markers 1578668 rat Bmd14 Bone mineral density QTL 14 6 3.8 38006 D6Rat69 35140 D6Rat22 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 6 6120187 85538444 1 - by flanking markers 6 6265856 75462111 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 6 6161722 76002731 1 - by flanking markers 6 11735669 72593685 1 - by flanking markers 1578669 rat Bss9 Bone structure and strength QTL 9 1 6.3 41058 D1Rat245 38782 D1Rat136 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307 16461031 1 249747 44907799 1 - by flanking markers 1 390736 37647484 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 254393 43579402 1 - by flanking markers 1 509108 43284926 1 - by flanking markers 1578670 rat Bss14 Bone structure and strength QTL 14 4 16.4 37378 D4Rat123 35070 D4Rat57 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 151627684 196627684 4 - by one flank marker only 4 89539438 134539438 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 87136446 132136446 4 - by one flank marker only 4 87327165 132327165 4 - by one flank marker only 1578671 rat Bmd10 Bone mineral density QTL 10 2 5.4 36912 D2Rat1 35915 D2Rat61 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307;2293187 16461031;17907919 Bmd1 (interacts with) 2 9324722 88595515 1 - by flanking markers 2 9670332 227150249 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 2 9444679 68866454 1 - by flanking markers 1578672 rat Bmd16 Bone mineral density QTL 16 10 6.2 38542 D10Rat132 35254 D10Rat2 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307 16461031 10 99844504 110568670 1 - by flanking markers 10 101222719 110718848 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 10 100155035 110992275 1 - by flanking markers 10 96703043 107057807 1 - by flanking markers 1578673 rat Bmd13 Bone mineral density QTL 13 5 4.9 41560 D5Rat153 39600 D5Rat154 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307 16461031 5 111095780 156095780 4 - by one flank marker only 5 108589975 153589975 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 5 107119214 152119214 4 - by one flank marker only 5 103689353 148689353 4 - by one flank marker only 1578674 rat Bmd12 Bone mineral density QTL 12 4 3.8 41458 D4Rat153 37340 D4Rat84 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307 16461031 4 201313537 246313537 4 - by one flank marker only 4 140398530 185398530 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 137171018 182171018 4 - by one flank marker only 4 135699135 180699135 4 - by one flank marker only 1578675 rat Bss17 Bone structure and strength QTL 17 9 3.8 37468 D9Rat162 35623 D9Rat41 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 9 1861508 14478042 1 - by flanking markers 9 4796492 8991332 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 9 1907834 15555026 1 - by flanking markers 9 3368652 13533896 1 - by flanking markers 1578754 rat Stresp16 Stress response QTL 16 3 4.0 0.001 33927 D3Mit3 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 recessive 3 125887975 170887975 5 - by peak with adj size 3 113902006 158902006 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 3 119471263 164471263 5 - by peak with adj size 3 112681431 157681431 5 - by peak with adj size 1578755 rat Pur5 Proteinuria QTL 5 8 3.3 1.0E-4 33559 D8Mit5 41310 D8Rat130 34763 D8Rat62 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520;2314528 16534143;19176703 8 33603024 100888674 1 - by flanking markers 8 32203394 98986263 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 8 33558660 109028082 2 - by one flank and peak markers 8 30848154 101699754 2 - by one flank and peak markers 1578756 rat Iddm22 Insulin dependent diabetes mellitus QTL 22 1 2.7 38202 D1Rat229 33931 D1Mit10 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) abnormal pancreatic islet morphology;hyperglycemia;increased susceptibility to autoimmune disorder hyperglycemia;type 1 diabetes mellitus;type 1 diabetes mellitus 1547853 16075370 3732 Sod2 1 13788254 58788254 4 - by one flank marker only 1578710 1578713 LEW.1AR1-iddm/Ztm BN/Ztm 1 50522714 57861469 1 - by flanking markers 1 11835181 56835181 4 - by one flank marker only 1578757 rat Pur6 Proteinuria QTL 6 9 3.3 0.005 62516 D9Uia4 66431 D9Mco6 61287 D9Uia6 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 9 67265475 99638395 2 - by one flank and peak markers 9 59247346 105580061 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 9 67451664 99920892 2 - by one flank and peak markers 9 62072275 96470995 2 - by one flank and peak markers 1578758 rat Tcas9 Tongue tumor susceptibility QTL 9 6 3.29 35647 D6Rat55 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 6 1 25028411 5 - by peak with adj size 6 1 25291384 5 - by peak with adj size 60997 61007 DA WF 6 1 25048718 5 - by peak with adj size 6 1 37618905 5 - by peak with adj size 1578759 rat Uae30 Urinary albumin excretion QTL 30 1 3.3 0.003 36703 D1Rat86 37168 D1Rat158 36703 D1Rat86 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 1 167535765 281205119 1 - by flanking markers 1 153578547 259173275 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 1 161321256 273791893 1 - by flanking markers 1 150700247 252085048 1 - by flanking markers 1578760 rat Cm53 Cardiac mass QTL 53 9 3.3 1.0E-4 66431 D9Mco6 61287 D9Uia6 61287 D9Uia6 heart mass (VT:0007028) heart wet weight (CMO:0000069) decreased heart weight Albuminuria;proteinuria 1578520 16534143 9 60951935 105951935 5 - by peak with adj size 9 77171049 105579863 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 9 61186278 106186278 5 - by peak with adj size 9 56771635 101771635 5 - by peak with adj size 1578761 rat Stresp21 Stress response QTL 21 10 3.3 39102 D10Rat71 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) anxiety disorder 1549862 16151695 recessive 10 7355194 52355194 5 - by peak with adj size 10 7041744 52041744 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 10 7521450 52521450 5 - by peak with adj size 10 6375746 51375746 5 - by peak with adj size 1578762 rat Toxo1 Toxoplasma gondii resistance QTL 1 10 37986 D10Rat116 37720 D10Rat80 brain integrity trait (VT:0010579) percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028) decreased susceptibility to parasitic infection toxoplasmosis 1578521 16407112 10 53807244 61030524 1 - by flanking markers 10 54220109 61798393 1 - by flanking markers 631593 631594 LEW/Rj BN/Rj 10 54057616 61300905 1 - by flanking markers 10 52200030 59378278 1 - by flanking markers 1578763 rat Kidm29 Kidney mass QTL 29 1 3.3 1.0E-4 35174 D1Rat66 66610 D1Mco35 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) abnormal kidney morphology Albuminuria;proteinuria 1578520 16534143 1 203383063 290094216 2 - by one flank and peak markers 1 183946692 267910886 2 - by one flank and peak markers 10041 724574 SS/Jr SHR/NHsd 1 196395041 282763074 2 - by one flank and peak markers 1 179567751 260522016 2 - by one flank and peak markers 1578764 rat Stresp19 Stress response QTL 19 19 3.6 0.001 41174 D19Rat71 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 recessive 19 29822065 72914587 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 19 18993982 62275575 5 - by peak with adj size 19 15630201 57337602 5 - by peak with adj size 1578765 rat Klgr1 Kidney lesion grade QTL 1 8 3.3 1.0E-4 41310 D8Rat130 33559 D8Mit5 34763 D8Rat62 kidney morphology trait (VT:0002135) organ lesion measurement (CMO:0000677) Albuminuria;proteinuria 1578520 16534143 8 33603128 100888495 1 - by flanking markers 8 32203499 98986085 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 8 33558660 109028082 2 - by one flank and peak markers 8 30848154 101699754 2 - by one flank and peak markers 1578766 rat Tcas11 Tongue tumor susceptibility QTL 11 5 4.12 22.7 34467 D5Mgh16 11072 D5Mgh2 2324 Cdkn2b tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 1578522 16527513 Tcas8 (maps to same region) 5 21842328 171522628 1 - by flanking markers 5 17517235 168005953 1 - by flanking markers 60997 734761 DA WF/Kga 5 47745646 167946134 2 - by one flank and peak markers 5 46711509 161317411 2 - by one flank and peak markers 1578767 rat Stresp17 Stress response QTL 17 5 4.3 0.01 35076 D5Rat6 blood aldosterone amount (VT:0005346) plasma aldosterone level (CMO:0000551) anxiety disorder 1549862 16151695 dominant 5 33639290 78639290 5 - by peak with adj size 5 30030683 75030683 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 5 29078899 74078899 5 - by peak with adj size 5 27955440 72955440 5 - by peak with adj size 1578768 rat Stresp22 Stress response QTL 22 16 2.8 40320 D16Rat66 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) anxiety disorder 1549862 16151695 additive 16 38671706 83671706 5 - by peak with adj size 16 39026337 84026337 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 16 39000021 84000021 5 - by peak with adj size 16 35288870 80288870 5 - by peak with adj size 1578769 rat Uae31 Urinary albumin excretion QTL 31 8 3.3 0.001 41310 D8Rat130 33559 D8Mit5 34763 D8Rat62 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520;2314528 16534143;19176703 8 33603128 100888495 1 - by flanking markers 8 32203499 98986085 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 8 33558660 109028082 2 - by one flank and peak markers 8 30848154 101699754 2 - by one flank and peak markers 1578770 rat Stresp23 Stress response QTL 23 1 60784 D1Wox29 11359 D1Arb21 kidney sympathetic nerve activity (VT:0004050) stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786) increased heart rate;increased renal sympathetic nerve activity;increased systemic arterial blood pressure anxiety disorder 1578503 16239369 1 131822204 206277202 1 - by flanking markers 1 124614679 187092492 1 - by flanking markers 1302636 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers 1578771 rat Stresp20 Stress response QTL 20 8 3.7 0.05 10302 D8Mgh14 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 recessive 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 1578772 rat Stresp14 Stress response QTL 14 2 5.0 0.001 40478 D2Rat277 38256 D2Rat115 39090 D2Rat180 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 2071 Agtr1b dominant 2 104097430 151745540 1 - by flanking markers 2 83433833 158985677 2 - by one flank and peak markers 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 2 84424139 132130578 1 - by flanking markers 2 82345893 130923501 1 - by flanking markers 1578773 rat Iddm23 Insulin dependent diabetes mellitus QTL 23 20 2.9 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) abnormal pancreatic islet morphology;hyperglycemia;increased susceptibility to autoimmune disorder hyperglycemia;type 1 diabetes mellitus;type 1 diabetes mellitus 1547853 16075370 1311139 Aire 1578710 1578713 LEW.1AR1-iddm/Ztm BN/Ztm 1578774 rat Tcas8 Tongue tumor susceptibility QTL 8 5 3.47 34377 D5Mgh4 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723;1578522 11429048;16527513 Tcas11 (maps to same region) 60997 61007 DA WF 1578775 rat Iddm21 Insulin dependent diabetes mellitus QTL 21 1 4.13 42536 D1Rat496 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) abnormal pancreatic islet morphology;hyperglycemia;increased susceptibility to autoimmune disorder hyperglycemia;type 1 diabetes mellitus;type 1 diabetes mellitus 1547853 16075370 2915;1308521 Ins1;Nkx2-3 1578710 1578713 LEW.1AR1-iddm/Ztm BN/Ztm 1578776 rat Stresp18 Stress response QTL 18 5 2.9 35076 D5Rat6 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) anxiety disorder 1549862 16151695 recessive 5 33639290 78639290 5 - by peak with adj size 5 30030683 75030683 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 5 29078899 74078899 5 - by peak with adj size 5 27955440 72955440 5 - by peak with adj size 1578777 rat Stresp15 Stress response QTL 15 2 2.0 0.05 40478 D2Rat277 blood aldosterone amount (VT:0005346) plasma aldosterone level (CMO:0000551) anxiety disorder 1549862 16151695 2071 Agtr1b dominant 2 81597542 126597542 5 - by peak with adj size 2 60933945 105933945 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 2 61924251 106924251 5 - by peak with adj size 2 59846005 104846005 5 - by peak with adj size 1578778 rat Pur4 Proteinuria QTL 4 1 3.3 0.003 36703 D1Rat86 37168 D1Rat158 36703 D1Rat86 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 1 167535765 281205119 1 - by flanking markers 1 153578547 259173275 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 1 161321256 273791893 1 - by flanking markers 1 150700247 252085048 1 - by flanking markers 1578779 rat Tcas10 Tongue tumor susceptibility QTL 10 10 3.12 11479 D10Mit8 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 10 32922090 77922090 5 - by peak with adj size 10 33351756 78351756 5 - by peak with adj size 60997 61007 DA WF 10 33179030 78179030 5 - by peak with adj size 10 31297439 76297439 5 - by peak with adj size 1578780 rat Cm52 Cardiac mass QTL 52 1 3.3 1.0E-4 66589 D1Mco25 37168 D1Rat158 heart mass (VT:0007028) heart wet weight (CMO:0000069) decreased heart weight Albuminuria;proteinuria 1578520 16534143 1 84046907 251024519 2 - by one flank and peak markers 1 81342810 225814178 2 - by one flank and peak markers 10041 724574 SS/Jr SHR/NHsd 1 82788437 239853971 2 - by one flank and peak markers 1 81591954 219808434 2 - by one flank and peak markers 1579915 rat Bp280 Blood pressure QTL 280 10 0.001 37150 D10Rat204 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1559293;1601352;1599557;2292238 16286573;17420333;17143582;18398331 Bp310 (sub_region) 10 93421499 112200500 4 - by one flank marker only 10 94837236 99588446 1 - by flanking markers 1579894 SS.LEW-(D10Rat204-D10Rat9)/Ayd 10 93662786 112626471 4 - by one flank marker only 10 90404397 107211142 4 - by one flank marker only 1579916 rat Bp270 Blood pressure QTL 270 2 0.003 1579094 D2Chm277 3407 Prlr arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased mean systemic arterial blood pressure hypertension 1358142;1599557;7421500 15827238;17143582;23814039 Bp310 (interacts with) 2 76472547 84554681 1 - by flanking markers 2 56722060 59701221 1 - by flanking markers 1549795 1579896 SS.LEW-(D2Rat199-D2Rat143)/Ayd SS.LEW-(D2Rat18-D2Chm277)/Ayd 2 56736401 60325686 1 - by flanking markers 2 56531912 59324719 1 - by flanking markers 1579917 rat Bp282 Blood pressure QTL 282 10 0.001 1579039 D10Chm169 1578994 D10Chm147 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 1559293;1599557;2292238 16286573;17143582;18398331 Bp312 (sub_region) 10 69442184 70215618 1 - by flanking markers 10 70654166 71447820 1 - by flanking markers 1579898 SS.LEW-(D10Chm128-D10Chm121)/Ayd 10 69808793 70581793 1 - by flanking markers 10 67400316 68164786 1 - by flanking markers 1579918 rat Bp279 Blood pressure QTL 279 10 0.01 1578839 D10Chm79 1578891 D10Chm29 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1559293;1599557;7421500;2292238 16286573;17143582;23814039;18398331 Bp256 (interacts with);Bp257 (interacts with);Bp308 (sub_region);Bp309 (sub_region);Bp310 (interacts with);Bp315 (interacts with);Bp346 (interacts with);Bp347 (interacts with);Bp365 (interacts with);Bp38 (interacts with) 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 1579919 rat Bp281 Blood pressure QTL 281 10 0.01 44776 D10Got92 1579130 D10Chm154 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1559293;1599557;2292238 16286573;17143582;18398331 Bp311 (sub_region) 10 76919480 97996556 1 - by flanking markers 10 77956239 99440638 1 - by flanking markers 724577 728384 SS.LEW-(D10Rat27-Igfbp4)/Ayd SS.LEW-(D10Rat24-Igfbp4)/Ayd 10 77055741 98282519 1 - by flanking markers 1579914 SS.LEW-(D10Mco30-D10Got92)/Ayd 10 74372084 94965338 1 - by flanking markers 1581497 rat Esta1 Estrogen-induced thymic atrophy QTL 1 10 0.1 36683 D10Rat42 34445 D10Mgh6 34318 D10Mgh10 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 1579780 16688534 incomplete_dominance 10 21575051 63366218 1 - by flanking markers 10 4831560 67678060 2 - by one flank and peak markers 10008 737892 BN/SsNHsd ACI/SegHsd 10 21707766 64648311 1 - by flanking markers 10 21329805 61345413 1 - by flanking markers 1581499 rat Esta2 Estrogen-induced thymic atrophy QTL 2 2 0.08 33727 D2Mit14 39240 D2Rat92 35915 D2Rat61 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 1579780 16688534 2 224018348 262226379 1 - by flanking markers 2 197256223 235940600 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 2 204585642 243689611 1 - by flanking markers 2 189599258 226936289 1 - by flanking markers 1581500 rat Renag1 Renal agenesis QTL 1 14 36053 D14Rat4 39774 D14Rat89 kidney development trait (VT:0000527) percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940) 1580355 16845468 incomplete_dominance 14 9714765 72873313 1 - by flanking markers 14 9428445 73480320 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 14 9756435 72854397 1 - by flanking markers 14 8170668 68298175 1 - by flanking markers 1581502 rat Esta3 Estrogen-induced thymic atrophy QTL 3 2 0.08 36466 D2Rat34 33727 D2Mit14 36466 D2Rat34 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 1579780 16688534 2 161739948 224018437 1 - by flanking markers 2 141755026 197256313 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 2 142053350 204585731 1 - by flanking markers 2 136916935 189599348 1 - by flanking markers 1581503 rat Cm58 Cardiac mass QTL 58 3 2.7 0.05 4.0 41780 D3Rat227 36717 D3Rat17 11261 D3Wox9 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 recessive 3 50522686 133513825 1 - by flanking markers 3 41054012 121619110 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 3 45406058 127023997 1 - by flanking markers 3 43827364 121056321 1 - by flanking markers 1581505 rat Rf54 Renal function QTL 54 5 38338 D5Rat108 36677 D5Rat31 kidney physiology trait (VT:0002136) kidney 20-HETE level (CMO:0001854) renal hypertension 1578407 16396943 2479;68945;628846;631356 Cyp4a2;Cyp4a1;Cyp4a8;Cyp4a3 5 137107818 142265366 1 - by flanking markers 5 134871897 139996194 1 - by flanking markers 1579899 1579902 SS.LEW-(D5Rat130-D5Rat31)/JrMcwi SS.LEW-(D5Rat130-D5Rat108)/JrMcwi 5 133313668 138454239 1 - by flanking markers 5 128033842 133011550 1 - by flanking markers 1581509 rat Cm57 Cardiac mass QTL 57 17 4.5 0.05 5.0 35735 D17Rat49 35827 D17Rat52 35827 D17Rat52 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 67385 Cacnb2 additive 17 86907303 86961249 1 - by flanking markers 17 70094251 97296363 5 - by peak with adj size 631275 631276 WKY/Cfd WKHA/Cfd 17 85183543 85236284 1 - by flanking markers 17 81153923 81208154 1 - by flanking markers 1581510 rat Cm54 Cardiac mass QTL 54 5 3.4 0.05 4.0 35545 D5Rat28 34210 D5Mgh14 40376 D5Rat173 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 recessive 5 129313212 153256206 1 - by flanking markers 5 126963761 150236260 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 5 125455818 149568944 1 - by flanking markers 5 120740824 143608494 1 - by flanking markers 1581512 rat Cm55 Cardiac mass QTL 55 17 2.8 0.05 5.0 34827 D17Rat12 36996 D17Rat31 34120 D17Mgh5 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 additive 17 29605177 63569326 1 - by flanking markers 17 33277173 65478569 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 17 27690959 61794615 1 - by flanking markers 17 27027949 56836890 1 - by flanking markers 1581516 rat Cm56 Cardiac mass QTL 56 12 4.2 0.05 3.0 34439 D12Mgh1 41956 D12Arb13 41956 D12Arb13 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 dominant 12 10334345 15941661 1 - by flanking markers 12 7382953 12240754 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 12 1 30749723 5 - by peak with adj size 12 1 29333307 5 - by peak with adj size 1581517 rat Bp284 Blood pressure QTL 284 9 1578935 D9Mco14 3555 Resp18 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1334447;2302803 15655120;18854752 3555 Resp18 Bp333 (maps to same region) 9 82125291 82246695 1 - by flanking markers 9 74436883 74558151 1 - by flanking markers 1579897 1579908 SS.SR-(D9Rat69-D9Mco14)/Mco SS.SR-(D9Mco95-Resp18)/Mco 9 82356030 82477136 1 - by flanking markers 9 76650629 76771824 1 - by flanking markers 1581519 rat Cm59 Cardiac mass QTL 59 15 2.8 0.05 3.0 34162 D15Mgh6 37500 D15Rat41 36149 D15Rat26 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 additive 15 100267081 107428111 2 - by one flank and peak markers 15 96375862 103677388 2 - by one flank and peak markers 631275 631276 WKY/Cfd WKHA/Cfd 15 96777066 104003672 2 - by one flank and peak markers 15 88853470 95840528 2 - by one flank and peak markers 1581544 rat Rf52 Renal function QTL 52 1 0.05 42282 D1Rat475 35457 D1Rat90 10674 D1Mgh12 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) 1578626 16541022 1 260169923 289137268 1 - by flanking markers 1 238613503 267111153 1 - by flanking markers 1579695 1579700 ACI.FHH-(D1Rat298-D1Rat90)/Eur ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur 1 252948438 281795785 1 - by flanking markers 1 232156370 259647894 1 - by flanking markers 1581546 rat Pur13 Proteinuria QTL 13 3 2.93 0.0335 51.8 35356 D3Rat5 35086 D3Rat31 34411 D3Mgh14 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 3 87839442 161185362 1 - by flanking markers 3 76620970 148642985 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 3 81136227 154416635 1 - by flanking markers 3 78196190 146592722 1 - by flanking markers 1581550 rat Pur8 Proteinuria QTL 8 6 10361 D6Wox13 11241 D6Mit3 66623 D6Uia5 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 6 85163291 144273721 1 - by flanking markers 6 75049644 136451997 1 - by flanking markers 1579696 SS.SHR-(D6Wox13-D6Rat84)/Mco 6 75623393 136142742 1 - by flanking markers 6 72227641 130729205 1 - by flanking markers 1581552 rat Pur12 Proteinuria QTL 12 2 5.19 9.0E-4 34.9 37016 D2Rat30 39754 D2Rat223 37456 D2Rat147 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 2 135417671 173567664 1 - by flanking markers 2 116504240 153393151 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 2 115721880 154182196 1 - by flanking markers 2 112103657 148076632 1 - by flanking markers 1581553 rat Pur14 Proteinuria QTL 14 17 5.3 1.0E-4 36.7 37386 D17Rat76 43082 D17Rat142 38992 D17Rat61 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 17 10600735 18672009 1 - by flanking markers 17 13930240 22447143 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 17 8424467 16620067 1 - by flanking markers 17 7979968 16317111 1 - by flanking markers 1581554 rat Pur11 Proteinuria QTL 11 13 37240 D13Rat63 33923 D13Mit1 11231 D13Wox5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level proteinuria 1578520 16534143 13 14282000 87877309 1 - by flanking markers 13 25430276 80482326 1 - by flanking markers 1579697 SS.SHR-(D13Rat63-D13Mit1)/Mco 13 9016906 82995569 1 - by flanking markers 13 5994833 77046787 1 - by flanking markers 1581555 rat Eae19 Experimental allergic encephalomyelitis QTL 19 15 4.7 34357 D15Mgh4 40106 D15Rat102 37584 D15Rat71 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) Experimental Autoimmune Encephalomyelitis 1549617 15716504 15 87456591 101499751 1 - by flanking markers 15 83349371 97700727 1 - by flanking markers 60997 737658 DA PVG.1AV1 15 83947714 98027710 1 - by flanking markers 15 76306099 90088744 1 - by flanking markers 1581557 rat Eae16 Experimental allergic encephalomyelitis QTL 16 8 3.8 36097 D8Rat56 36781 D8Rat11 37324 D8Rat75 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) CNS inflammation;abnormal voluntary movement Experimental Autoimmune Encephalomyelitis;Experimental Autoimmune Encephalomyelitis;Paresis;multiple sclerosis 629629 12517974 recessive 8 9505886 118551460 1 - by flanking markers 8 8294860 115338082 1 - by flanking markers 737657 737658 LEW.1AV1 PVG.1AV1 8 9531047 119211942 1 - by flanking markers 8 8462195 110921472 1 - by flanking markers 1581559 rat Eae18 Experimental allergic encephalomyelitis QTL 18 10 2.0E-5 35254 D10Rat2 35228 D10Rat29 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) Experimental Autoimmune Encephalomyelitis 1302800;2293859;2296064 11486278;16624898;18453595 Eae23 (sub_region);Eau9 (maps to same region) 10 67642304 110568486 1 - by flanking markers 10 23843272 68843272 4 - by one flank marker only 1331816 DA.ACI-(D10Rat2-D10Rat29)/Kini 10 67988218 110992091 1 - by flanking markers 10 107057622 107211142 4 - by one flank marker only 1581561 rat Eae22 Experimental allergic encephalomyelitis QTL 22 4 60421 D4Got135 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) Experimental Autoimmune Encephalomyelitis 1547849 15634914 4 190919460 235919460 5 - by peak with adj size 4 145746752 187126005 5 - by peak with adj size 60997 737658 DA PVG.1AV1 1581563 rat Uae33 Urinary albumin excretion QTL 33 6 10361 D6Wox13 11241 D6Mit3 66623 D6Uia5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 6 85163291 144273721 1 - by flanking markers 6 75049644 136451997 1 - by flanking markers 1579696 SS.SHR-(D6Wox13-D6Rat84)/Mco 6 75623393 136142742 1 - by flanking markers 6 72227641 130729205 1 - by flanking markers 1581565 rat Pur10 Proteinuria QTL 10 11 1.0E-4 37512 D11Rat50 39698 D11Rat67 37512 D11Rat50 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level proteinuria 1578520 16534143 11 50441007 90087331 1 - by flanking markers 11 45797929 84840963 1 - by flanking markers 1579691 SS.SHR-(D11Mgh3-D11Rat31)/Mco 11 47264023 86994547 1 - by flanking markers 11 44803318 82846466 1 - by flanking markers 1581566 rat Eae21 Experimental allergic encephalomyelitis QTL 21 4 6.2 43012 D14Rat113 60419 D4Got132 60418 D4Got131 body mass (VT:0001259) maximum body weight loss to initial body weight ratio (CMO:0001400) Experimental Autoimmune Encephalomyelitis 1547849 15634914 4 224422165 225566369 2 - by one flank and peak markers 4 162206044 162362144 2 - by one flank and peak markers 60997 737658 DA PVG.1AV1 4 157399119 158564471 2 - by one flank and peak markers 4 157680158 158841762 2 - by one flank and peak markers 1581568 rat Rf53 Renal function QTL 53 3 38686 D3Rat84 36759 D3Rat59 33808 D3Mit4 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) 1578626 16541022 3 64689438 176609927 1 - by flanking markers 3 53876762 163443738 1 - by flanking markers 1579678 1579700 ACI.FHH-(D3Wox2-D3Rat59)/Eur ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur 3 58204463 170534769 1 - by flanking markers 3 56395968 161299569 1 - by flanking markers 1581569 rat Uae32 Urinary albumin excretion QTL 32 2 1.0E-4 35915 D2Rat61 66661 D2Mco18 38312 D2Rat179 urine protein amount (VT:0005160) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520;1625111 16534143;17504948 2 88594475 100298539 1 - by flanking markers 2 79796977 227150051 1 - by flanking markers 1579703 SS.SHR-(D2Rat61-D2Mco18)/Mco 2 68865414 80632096 1 - by flanking markers 2 78665619 219826953 2 - by one flank and peak markers 1581570 rat Eae17 Experimental allergic encephalomyelitis QTL 17 13 4.1 39436 D13Rat142 37180 D13Rat64 34833 D13Rat19 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) CNS inflammation;abnormal voluntary movement Experimental Autoimmune Encephalomyelitis;Experimental Autoimmune Encephalomyelitis;Paresis;multiple sclerosis 629629 12517974 dominant 13 17433838 113098593 1 - by flanking markers 13 28645448 106366082 1 - by flanking markers 737657 737658 LEW.1AV1 PVG.1AV1 13 12193394 108478121 1 - by flanking markers 13 8897350 101631289 1 - by flanking markers 1581572 rat Uae35 Urinary albumin excretion QTL 35 11 1.0E-4 37512 D11Rat50 39698 D11Rat67 37512 D11Rat50 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 11 50441007 90087331 1 - by flanking markers 11 45797929 84840963 1 - by flanking markers 1579691 SS.SHR-(D11Mgh3-D11Rat31)/Mco 11 47264023 86994547 1 - by flanking markers 11 44803318 82846466 1 - by flanking markers 1581573 rat Uae36 Urinary albumin excretion QTL 36 13 37240 D13Rat63 33923 D13Mit1 11231 D13Wox5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 13 14282000 87877309 1 - by flanking markers 13 25430276 80482326 1 - by flanking markers 1579697 SS.SHR-(D13Rat63-D13Mit1)/Mco 13 9016906 82995569 1 - by flanking markers 13 5994833 77046787 1 - by flanking markers 1581574 rat Eae20 Experimental allergic encephalomyelitis QTL 20 4 7.8 43012 D14Rat113 60419 D4Got132 34473 D4Mgh10 nervous system integrity trait (VT:0010566) percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047) Experimental Autoimmune Encephalomyelitis 1547849 15634914 4 219525801 225566369 2 - by one flank and peak markers 4 155974180 162362144 2 - by one flank and peak markers 60997 737658 DA PVG.1AV1 4 152482121 158564471 2 - by one flank and peak markers 4 153031106 158841762 2 - by one flank and peak markers 1581576 rat Pur7 Proteinuria QTL 7 2 1.0E-4 35915 D2Rat61 66661 D2Mco18 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 2 88594475 100298539 1 - by flanking markers 2 79796977 227150051 1 - by flanking markers 1579703 SS.SHR-(D2Rat61-D2Mco18)/Mco 2 68865414 80632096 1 - by flanking markers 1581577 rat Pur15 Proteinuria QTL 15 20 4.38 2.0E-4 23.6 37632 D20Rat49 35657 D20Rat5 34872 D20Rat3 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 20 10844023 21025734 1 - by flanking markers 20 8286533 18411969 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 20 8654341 18872273 1 - by flanking markers 20 8042410 17617956 1 - by flanking markers 1581578 rat Cm49 Cardiac mass QTL 49 2 4.9 0.01 34005 D2Mit8 35915 D2Rat61 34497 D2Mgh24 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578627 16286240 2609;61973;621276;628721;631398 Fgf2;Trpc3;Trpc4;Sclt1;Kcnmb2 2 88595515 169047256 1 - by flanking markers 2 148790600 227150249 1 - by flanking markers 60994 1302620 F344 SHR/Kyo 2 68866454 149614466 1 - by flanking markers 2 127447387 143657569 2 - by one flank and peak markers 1581580 rat Uae34 Urinary albumin excretion QTL 34 9 66431 D9Mco6 62516 D9Uia4 61287 D9Uia6 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 9 67265475 99638395 2 - by one flank and peak markers 9 59247627 105579863 1 - by flanking markers 1579702 SS.SHR-(D9Wox16-D9Rat64)/Mco 9 67451664 99920892 2 - by one flank and peak markers 9 62072275 96470995 2 - by one flank and peak markers 1582197 rat Gluco27 Glucose level QTL 27 14 3.4 6.0E-4 15.0 41986 D14Arb10 39030 D14Rat38 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582199 rat Insul5 Insulin level QTL 5 17 3.4 0.0119 12.0 40956 D17Rat107 38706 D17Rat84 40956 D17Rat107 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582201 rat Sffal2 Serum free fatty acids level QTL 2 14 4.0 2.0E-4 20.0 39030 D14Rat38 35897 D14Rat22 35897 D14Rat22 blood free fatty acid amount (VT:0001553) serum free fatty acids level (CMO:0000547) Metabolic Syndrome 1580752 15728334 14 102293972 106705037 1 - by flanking markers 14 99079814 102509397 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 102549183 106641756 1 - by flanking markers 14 92553886 95876975 1 - by flanking markers 1582203 rat Gluco19 Glucose level QTL 19 9 3.3 0.001 15.0 38036 D9Rat64 36027 D9Rat3 38036 D9Rat64 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Bw64 (interacts with) 9 98715385 107462796 1 - by flanking markers 9 91131330 99799902 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 9 99041068 107878528 1 - by flanking markers 9 92491589 100929786 1 - by flanking markers 1582204 rat Livw1 Liver weight QTL 1 1 3.6 3.0E-4 13.0 35591 D1Rat47 34399 D1Mgh9 41532 D1Rat280 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) increased liver weight Metabolic Syndrome 1580752 15728334 1 172296302 195235510 1 - by flanking markers 1 158511072 176855135 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 1 166100317 188289386 1 - by flanking markers 1 155422851 172949803 1 - by flanking markers 1582206 rat Kidm33 Kidney mass QTL 33 1 6.9 23.0 35851 D1Rat68 37902 D1Rat169 10768 D1Wox22 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight Metabolic Syndrome 1580752 15728334 1 212591076 251652933 1 - by flanking markers 1 193069836 229876997 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 1 205603081 244401301 1 - by flanking markers 1 188377360 224054420 1 - by flanking markers 1582208 rat Kidm32 Kidney mass QTL 32 17 3.9 0.0018 14.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) increased kidney weight Metabolic Syndrome 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582209 rat Gluco20 Glucose level QTL 20 14 3.8 5.0E-4 17.0 41986 D14Arb10 39030 D14Rat38 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Gluco24 (interacts with) 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582210 rat Bw71 Body weight QTL 71 3 3.3 0.0012 11.0 35589 D3Rat37 42664 D3Rat257 41296 D3Rat166 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 73270750 126355468 1 - by flanking markers 3 62558027 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 66711607 119830094 1 - by flanking markers 3 64655305 115665732 1 - by flanking markers 1582212 rat Livw2 Liver weight QTL 2 5 3.5 4.0E-4 12.0 38512 D5Rat80 39952 D5Rat158 60808 D5Wox25 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) increased liver weight Metabolic Syndrome 1580752 15728334 5 106525895 127710319 2 - by one flank and peak markers 5 103701215 125255195 2 - by one flank and peak markers intercross 728161 737899 PD/Cub BN/Cub 5 102498468 123852688 2 - by one flank and peak markers 5 99016066 119085810 2 - by one flank and peak markers 1582213 rat Insul6 Insulin level QTL 6 3 3.7 9.0E-4 13.0 38236 D3Rat213 41132 D3Rat143 41132 D3Rat143 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 Sffal1 (interacts with) intercross 728161 737899 PD/Cub BN/Cub 1582214 rat Stl21 Serum triglyceride level QTL 21 15 3.1 0.022 11.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582216 rat Bw65 Body weight QTL 65 3 6.3 19.0 41296 D3Rat166 42664 D3Rat257 41296 D3Rat166 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Insul8 (interacts with) 3 113470189 126355468 1 - by flanking markers 3 101359810 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 106900427 119830094 1 - by flanking markers 3 102200529 115665732 1 - by flanking markers 1582218 rat Bw74 Body weight QTL 74 3 3.9 0.0021 13.0 34146 D3Mgh6 42664 D3Rat257 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 61249840 126355468 1 - by flanking markers 3 50522618 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 119830094 1 - by flanking markers 3 53184593 115665732 1 - by flanking markers 1582219 rat Bw63 Body weight QTL 63 3 3.8 0.001 12.0 38328 D3Rat81 42664 D3Rat257 41296 D3Rat166 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 107333676 126355468 1 - by flanking markers 3 86696150 116023640 2 - by one flank and peak markers intercross 728161 737899 PD/Cub BN/Cub 3 100730984 119830094 1 - by flanking markers 3 96127817 115665732 1 - by flanking markers 1582221 rat Kidm30 Kidney mass QTL 30 3 3.5 8.0E-4 12.0 35589 D3Rat37 42664 D3Rat257 41296 D3Rat166 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) increased kidney weight Metabolic Syndrome 1580752 15728334 3 73270750 126355468 1 - by flanking markers 3 62558027 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 66711607 119830094 1 - by flanking markers 3 64655305 115665732 1 - by flanking markers 1582222 rat Epfw2 Epididymal fat weight QTL 2 8 3.2 5.0E-4 14.0 36161 D8Rat36 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 8 34506868 79506868 5 - by peak with adj size 8 34808657 79808657 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 8 35925594 80925594 5 - by peak with adj size 8 31737729 76737729 5 - by peak with adj size 1582224 rat Epfw4 Epididymal fat weight QTL 4 17 3.5 0.0058 12.0 40956 D17Rat107 38706 D17Rat84 40956 D17Rat107 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582225 rat Bw67 Body weight QTL 67 17 6.2 1.0E-4 19.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752;2312611 15728334;19697080 Bw64 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Bw91 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582226 rat Bw64 Body weight QTL 64 17 4.2 0.0017 13.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Gluco19 (interacts with);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582227 rat Gluco30 Glucose level QTL 30 15 3.6 3.0E-4 13.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Insul8 (interacts with) 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582228 rat Epfw3 Epididymal fat weight QTL 3 15 4.1 2.0E-4 14.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582229 rat Stl20 Serum triglyceride level QTL 20 8 3.2 0.0033 14.0 36872 D8Rat43 44411 D8Got72 36872 D8Rat43 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome 1580752 15728334 8 51241951 51710641 1 - by flanking markers 8 51577566 52065790 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 8 52644745 53117620 1 - by flanking markers 8 48630131 49147989 1 - by flanking markers 1582230 rat Bw78 Body weight QTL 78 5 3.2 0.0016 11.0 39952 D5Rat158 38338 D5Rat108 10454 D5Wox12 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased total body fat amount Metabolic Syndrome;obesity 1580752 15728334 5 127710120 137108002 1 - by flanking markers 5 125254995 134872385 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 5 123852489 133313852 1 - by flanking markers 5 119085612 128034027 1 - by flanking markers 1582232 rat Gluco25 Glucose level QTL 25 4 3.6 0.0023 16.0 35721 D4Rat76 37592 D4Rat141 37592 D4Rat141 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 4 150964994 210231755 1 - by flanking markers 4 84886545 151158853 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 4 86312589 146942261 1 - by flanking markers 4 85253748 148090731 1 - by flanking markers 1582233 rat Insul10 Insulin level QTL 10 3 5.4 0.0015 18.0 38236 D3Rat213 41132 D3Rat143 38236 D3Rat213 blood insulin amount (VT:0001560) serum insulin level times blood glucose level (CMO:0002040) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 intercross 728161 737899 PD/Cub BN/Cub 1582234 rat Gluco18 Glucose level QTL 18 1 3.4 3.0E-4 12.0 39320 D1Rat220 36432 D1Rat35 39320 D1Rat220 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 1 86959064 131959064 4 - by one flank marker only 1 79749065 124749065 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 1 85917265 130917265 4 - by one flank marker only 1 78479925 123479925 4 - by one flank marker only 1582235 rat Insul8 Insulin level QTL 8 16 3.3 0.0063 15.0 33848 D16Mit2 33652 D16Mit5 33848 D16Mit2 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 Bw65 (interacts with);Gluco30 (interacts with) 16 1 27496499 5 - by peak with adj size 16 1 26804456 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 16 1 27556253 5 - by peak with adj size 16 1 26727669 5 - by peak with adj size 1582236 rat Gluco22 Glucose level QTL 22 14 3.3 0.0164 15.0 41986 D14Arb10 39030 D14Rat38 41986 D14Arb10 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582237 rat Kidm34 Kidney mass QTL 34 4 4.0 1.0E-4 19.0 37592 D4Rat141 36486 D4Rat68 10049 D4Wox16 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight Metabolic Syndrome 1580752 15728334 4 210231569 233267140 1 - by flanking markers 4 151158666 172169650 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 4 146942075 168998263 1 - by flanking markers 4 148090542 168069246 1 - by flanking markers 1582238 rat Bw68 Body weight QTL 68 3 3.2 0.0064 11.0 34146 D3Mgh6 42664 D3Rat257 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 61249840 126355468 1 - by flanking markers 3 50522618 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 119830094 1 - by flanking markers 3 53184593 115665732 1 - by flanking markers 1582239 rat Epfw1 Epididymal fat weight QTL 1 3 4.5 6.0E-4 16.0 34146 D3Mgh6 42664 D3Rat257 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 3 61249840 126355468 1 - by flanking markers 3 50522618 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 119830094 1 - by flanking markers 3 53184593 115665732 1 - by flanking markers 1582240 rat Sffal1 Serum free fatty acids level QTL 1 7 3.4 0.0021 12.0 38306 D7Rat97 35681 D7Rat5 35681 D7Rat5 blood free fatty acid amount (VT:0001553) serum free fatty acids level (CMO:0000547) Metabolic Syndrome 1580752 15728334 Insul6 (interacts with) 7 126176882 133771186 1 - by flanking markers 7 123574473 131350792 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 7 126463649 134098026 1 - by flanking markers 7 116677010 124049952 1 - by flanking markers 1582241 rat Bw70 Body weight QTL 70 17 4.6 3.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582242 rat Gluco28 Glucose level QTL 28 15 3.3 8.0E-4 11.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582243 rat Bw66 Body weight QTL 66 8 3.4 0.0048 15.0 36161 D8Rat36 37324 D8Rat75 36161 D8Rat36 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 8 57006784 91507228 1 - by flanking markers 8 57308572 89558994 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 8 58425510 91990535 1 - by flanking markers 8 54237644 85365202 1 - by flanking markers 1582244 rat Bw79 Body weight QTL 79 15 4.0 2.0E-4 14.0 35120 D15Rat6 34409 D15Mgh9 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased total body fat amount Metabolic Syndrome;obesity 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582245 rat Bw73 Body weight QTL 73 17 4.6 4.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582246 rat Cm60 Cardiac mass QTL 60 2 5.8 24.0 35272 D2Rat19 33620 D2Mit6 35272 D2Rat19 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;Metabolic Syndrome 1580752 15728334 2 79200355 98153468 1 - by flanking markers 2 58117457 77630814 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 2 57715603 78466260 1 - by flanking markers 2 57605612 76539510 1 - by flanking markers 1582248 rat Insul7 Insulin level QTL 7 3 3.9 0.0041 14.0 41132 D3Rat143 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 intercross 728161 737899 PD/Cub BN/Cub 1582249 rat Bw77 Body weight QTL 77 3 3.2 0.0025 12.0 34146 D3Mgh6 35589 D3Rat37 34146 D3Mgh6 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased total body fat amount Metabolic Syndrome;obesity 1580752 15728334 3 61249840 73270928 1 - by flanking markers 3 50522618 62558206 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 66711785 1 - by flanking markers 3 53184593 64655484 1 - by flanking markers 1582250 rat Gluco26 Glucose level QTL 26 14 3.3 9.0E-4 15.0 41986 D14Arb10 35897 D14Rat22 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 106705037 1 - by flanking markers 14 78978644 102509397 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 106641756 1 - by flanking markers 14 73415323 95876975 1 - by flanking markers 1582251 rat Gluco24 Glucose level QTL 24 15 3.2 8.0E-4 11.0 35120 D15Rat6 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Gluco20 (interacts with) 15 14603280 59603280 5 - by peak with adj size 15 10138595 55138595 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 15 10719191 55719191 5 - by peak with adj size 15 5530756 50530756 5 - by peak with adj size 1582252 rat Sual1 Serum uric acid level QTL 1 3 3.4 0.0123 12.0 38328 D3Rat81 41296 D3Rat166 38328 D3Rat81 blood uric acid amount (VT:0010302) blood uric acid level (CMO:0000501) Metabolic Syndrome 1580752 15728334 3 107333676 113470358 1 - by flanking markers 3 56359980 101359980 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 3 100730984 106900596 1 - by flanking markers 3 96127817 102200699 1 - by flanking markers 1582254 rat Kidm31 Kidney mass QTL 31 8 3.0 36161 D8Rat36 37324 D8Rat75 36161 D8Rat36 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) increased kidney weight Metabolic Syndrome 1580752 15728334 8 57006784 91507228 1 - by flanking markers 8 57308572 89558994 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 8 58425510 91990535 1 - by flanking markers 8 54237644 85365202 1 - by flanking markers 1582255 rat Gluco29 Glucose level QTL 29 14 3.1 0.0025 14.0 41986 D14Arb10 39030 D14Rat38 41986 D14Arb10 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582256 rat Insul9 Insulin level QTL 9 3 4.4 0.0016 15.0 38236 D3Rat213 41132 D3Rat143 41132 D3Rat143 blood insulin amount (VT:0001560) absolute change in serum insulin level (CMO:0002038) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 intercross 728161 737899 PD/Cub BN/Cub 1582257 rat Gluco21 Glucose level QTL 21 2 3.1 0.0035 11.0 41358 D2Rat217 36213 D2Rat40 66654 D2Mco14 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 2 141390480 189197988 1 - by flanking markers 2 121545310 163154358 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 2 121750419 169852800 1 - by flanking markers 2 118111229 157142209 1 - by flanking markers 1582258 rat Bw76 Body weight QTL 76 17 4.6 5.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582259 rat Gluco23 Glucose level QTL 23 14 3.1 8.0E-4 14.0 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 79794074 115151701 5 - by peak with adj size 14 76579917 112194335 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 14 80049285 115493446 5 - by peak with adj size 14 70053989 104886043 5 - by peak with adj size 1582260 rat Bw72 Body weight QTL 72 7 3.2 0.0043 15.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw69 (maps to same region);Bw75 (maps to same region) 7 20386476 44693197 1 - by flanking markers 7 1 41004865 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 7 20215583 44668493 1 - by flanking markers 7 15795565 38073970 1 - by flanking markers 1582261 rat Bw69 Body weight QTL 69 7 3.2 0.0048 14.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw72 (maps to same region);Bw75 (maps to same region) 7 20386476 44693197 1 - by flanking markers 7 1 41004865 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 7 20215583 44668493 1 - by flanking markers 7 15795565 38073970 1 - by flanking markers 1582262 rat Bw75 Body weight QTL 75 7 3.0 0.0038 14.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw69 (maps to same region);Bw72 (maps to same region) 7 20386476 44693197 1 - by flanking markers 7 1 41004865 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 7 20215583 44668493 1 - by flanking markers 7 15795565 38073970 1 - by flanking markers 1598805 rat Memor8 Memory QTL 8 2 3.0 33747 D2Mit10 10200 D2Mgh11 1303105 Dear exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 2 177277106 223460027 1 - by flanking markers 2 155920709 197555821 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 157914311 204022555 1 - by flanking markers 2 150341585 189039377 1 - by flanking markers 1598807 rat Glom12 Glomerulus QTL 12 5 2.7 33678 D5Mit10 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 5 38938687 83938687 5 - by peak with adj size 5 35474610 80474610 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 34402409 79402409 5 - by peak with adj size 5 33215665 78215665 5 - by peak with adj size 1598809 rat Memor15 Memory QTL 15 X 4.4 40522 DXRat98 34783 DXRat21 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 X 122686596 144384190 2 - by one flank and peak markers X 9007287 160699376 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 110957467 155957467 5 - by peak with adj size X 103312877 148312877 5 - by peak with adj size 1598811 rat Bp291 Blood pressure QTL 291 11 1.9 34150 D11Mgh5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1581737 16720678 11 25137329 70137329 5 - by peak with adj size 11 20656936 65656936 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 11 21944229 66944229 5 - by peak with adj size 1598813 rat Memor9 Memory QTL 9 2 2.7 39040 D2Rat169 34864 D2Rat67 35613 D2Rat59 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 2 234324242 269740088 1 - by flanking markers 2 207443643 243502158 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 214870793 251212353 1 - by flanking markers 2 199341726 234244620 1 - by flanking markers 1598814 rat Mcs13 Mammary carcinoma susceptibility QTL 13 5 1.0E-4 1581996 D5Uwm65 1582030 D5Uwm66 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) Experimental Mammary Neoplasms 1559294 16266982 5 72838045 76105732 1 - by flanking markers 5 65553185 73080336 1 - by flanking markers 1581627 1581632 WF.WKY-(D5Uwm66-D5Uwm67)/Uwm WF.WKY-(D5Uwm65-D5Uwm60)/Uwm 5 68395096 71941113 1 - by flanking markers 5 63190890 69927503 1 - by flanking markers 1598816 rat Memor12 Memory QTL 12 20 2.4 37792 D20Rat29 38836 D20Rat37 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 20 5747478 50747478 4 - by one flank marker only 20 3055886 48055886 4 - by one flank marker only intercross 1582184 1582190 SR/JrHsd SS/JrHsd 20 4108956 49108956 4 - by one flank marker only 20 2606836 47606836 4 - by one flank marker only 1598817 rat Glom13 Glomerulus QTL 13 1 2.2 11201 D1Mgh11 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598819 rat Bp292 Blood pressure QTL 292 5 4.3 38916 D5Rat106 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737;7364997 16720678;22860086 Bp359 (sub_region) 5 137693256 177180328 5 - by peak with adj size 5 134356746 173096209 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 133943857 173707219 5 - by peak with adj size 5 127798274 166875058 5 - by peak with adj size 1598821 rat Rf55 Renal function QTL 55 1 6.3 36866 D1Rat73 36169 D1Rat89 41680 D1Rat376 renal blood flow trait (VT:2000006) ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239) 1579884 16303858 1 246113306 287349830 1 - by flanking markers 1 224420592 265343617 1 - by flanking markers intercross 629509 629520 FHH/EurMcwi FHH-Chr 1BN/Mcwi 1 238824734 279986079 1 - by flanking markers 1 218748008 257976495 1 - by flanking markers 1598823 rat Memor16 Memory QTL 16 9 1.9 40022 D9Rat152 39362 D9Rat92 37604 D9Rat76 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 9 24616151 54591542 1 - by flanking markers 9 18410299 47035878 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 25754320 54885226 1 - by flanking markers 9 22133322 49968732 1 - by flanking markers 1598824 rat Memor4 Memory QTL 4 8 2.5 33628 D8Mit6 41026 D8Rat153 36673 D8Rat49 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 8 11331331 56117827 1 - by flanking markers 8 9581132 56397678 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 8 11373267 57541668 1 - by flanking markers 8 9712220 53356647 1 - by flanking markers 1598826 rat Anxrr20 Anxiety related response QTL 20 18 3.04 36638 D18Rat14 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) anxiety disorder 1578499 16490266 18 45470403 87229863 5 - by peak with adj size 18 44524337 87265094 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 18 46319476 88201929 5 - by peak with adj size 18 41432971 83828827 5 - by peak with adj size 1598828 rat Glom14 Glomerulus QTL 14 15 2.5 40554 D15Rat93 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 15 44708822 89708822 5 - by peak with adj size 15 40091127 85091127 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 15 41068094 86068094 5 - by peak with adj size 15 34054139 79054139 5 - by peak with adj size 1598830 rat Bp288 Blood pressure QTL 288 1 3.5 11201 D1Mgh11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598832 rat Glom11 Glomerulus QTL 11 18 2.9 40918 D18Rat80 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 18 49752721 86965151 3 - by peak only 18 54435837 87265094 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598833 rat Bp295 Blood pressure QTL 295 2 3.5 1303105 Dear arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 2 181146893 226146893 5 - by peak with adj size 2 154238265 199238265 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 161745602 206745602 5 - by peak with adj size 2 147798556 192798556 5 - by peak with adj size 1598834 rat Memor11 Memory QTL 11 9 2.5 37604 D9Rat76 33999 D9Mit5 39362 D9Rat92 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 620218 Creb1 9 40929725 89766058 1 - by flanking markers 9 33496794 75633613 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 41261034 90024806 1 - by flanking markers 9 36962359 77814038 1 - by flanking markers 1598835 rat Anxrr18 Anxiety related response QTL 18 2 2.98 39118 D2Rat139 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) anxiety disorder 1578499 16490266 2 236268996 281268996 5 - by peak with adj size 2 210033012 255033012 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 2 217743855 262743855 5 - by peak with adj size 2 200990457 245990457 5 - by peak with adj size 1598837 rat Memor13 Memory QTL 13 X 3.2 36952 DXRat11 36735 DXRat32 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 X 44619917 154597545 2 - by one flank and peak markers X 62691290 160699376 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 44320616 158345622 2 - by one flank and peak markers X 41052407 146860749 2 - by one flank and peak markers 1598838 rat Bp290 Blood pressure QTL 290 2 1.9 10200 D2Mgh11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 2 200959916 245959916 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 181522444 226522444 5 - by peak with adj size 2 166539266 211539266 5 - by peak with adj size 1598839 rat Rf56 Renal function QTL 56 1 10805 D1Mgh13 36169 D1Rat89 renal blood flow trait (VT:2000006) ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239) 1579884 16303858 1 274224224 287349830 1 - by flanking markers 1 252340389 265343617 1 - by flanking markers 1582193 FHH.FHH.1BN-(D1Mgh13-D1Rat89)/Mcwi 1 266793821 279986079 1 - by flanking markers 1 245907761 257976495 1 - by flanking markers 1598841 rat Memor7 Memory QTL 7 11 34150 D11Mgh5 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 11 25137329 70137329 5 - by peak with adj size 11 20656936 65656936 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 11 21944229 66944229 5 - by peak with adj size 1598842 rat Glom10 Glomerulus QTL 10 11 3.4 41734 D11Rat101 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 11 1 37535625 5 - by peak with adj size 11 1 35465693 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 11 1 33867429 5 - by peak with adj size 11 1 35331169 5 - by peak with adj size 1598843 rat Cm63 Cardiac mass QTL 63 6 2.6 37142 D6Rat80 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) decreased heart weight Cardiomegaly;Hypotension 1581737 16720678 6 1 23611623 5 - by peak with adj size 6 1 23802078 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 6 1 23620518 5 - by peak with adj size 6 1 39036266 5 - by peak with adj size 1598845 rat Mcs14 Mammary carcinoma susceptibility QTL 14 5 1.0E-4 1582044 D5Uwm67 1582002 D5Uwm61 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) Experimental Mammary Neoplasms 1559294;5684388 16266982;21205740 Mcs28 (sub_region);Mcs29 (sub_region) 5 82897463 87363048 1 - by flanking markers 5 79919505 84434576 1 - by flanking markers 1581641 WF.WKY-(D5Uwm68-D5Mit4)/Uwm 5 78777540 83269259 1 - by flanking markers 5 76369776 80813390 1 - by flanking markers 1598846 rat Bp293 Blood pressure QTL 293 5 3.9 35074 D5Rat23 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737;7364997 16720678;22860086 621139 Bsnd 5 87410667 132410667 5 - by peak with adj size 5 84392127 129392127 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 83424556 128424556 5 - by peak with adj size 5 79584860 124584860 5 - by peak with adj size 1598847 rat Cm62 Cardiac mass QTL 62 5 3.4 33680 D5Mit13 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 5 117929881 162929881 5 - by peak with adj size 5 115772027 160772027 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 114140832 159140832 5 - by peak with adj size 5 108845856 153845856 5 - by peak with adj size 1598849 rat Memor17 Memory QTL 17 9 2.2 39362 D9Rat92 36556 D9Rat10 33999 D9Mit5 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 9 54591357 76457525 1 - by flanking markers 9 47035692 68493058 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 54885041 76677636 1 - by flanking markers 9 49968546 71098346 1 - by flanking markers 1598850 rat Bp297 Blood pressure QTL 297 1 2.1 34868 D1Rat45 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 1 137638872 182638872 5 - by peak with adj size 1 123689796 168689796 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 131334152 176334152 5 - by peak with adj size 1 121006655 166006655 5 - by peak with adj size 1598852 rat Anxrr19 Anxiety related response QTL 19 10 5.07 39038 D10Rat104 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) anxiety disorder 1578499 16490266 additive 10 19219508 64219508 5 - by peak with adj size 10 19468218 64468218 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 10 19402814 64402814 5 - by peak with adj size 10 18167841 63167841 5 - by peak with adj size 1598853 rat Memor3 Memory QTL 3 1 4.5 34868 D1Rat45 35525 D1Rat116 37184 D1Rat188 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 1 160138797 239429964 1 - by flanking markers 1 146189650 218467340 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 153834077 232297227 1 - by flanking markers 1 143506580 212458660 1 - by flanking markers 1598854 rat Memor10 Memory QTL 10 3 2.0 36584 D3Rat6 36759 D3Rat59 41322 D3Rat137 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 3 158307259 176609927 1 - by flanking markers 3 147990566 163443738 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 3 153412455 170534769 1 - by flanking markers 3 145956084 161299569 1 - by flanking markers 1598855 rat Bp294 Blood pressure QTL 294 12 3.5 33911 D12Mit6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 12 1 38944117 5 - by peak with adj size 12 1 35270263 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 12 1 36919844 5 - by peak with adj size 12 1 34851688 5 - by peak with adj size 1598856 rat Memor1 Memory QTL 1 X 1.9 40522 DXRat98 34783 DXRat21 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581736;1581615 14665699;16837653 X 122686596 144384190 2 - by one flank and peak markers X 9007287 160699376 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 110957467 155957467 5 - by peak with adj size X 103312877 148312877 5 - by peak with adj size 1598858 rat Cm61 Cardiac mass QTL 61 20 3.6 38836 D20Rat37 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598859 rat Cm66 Cardiac mass QTL 66 5 2.0 35074 D5Rat23 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 5 87410667 132410667 5 - by peak with adj size 5 84392127 129392127 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 83424556 128424556 5 - by peak with adj size 5 79584860 124584860 5 - by peak with adj size 1598861 rat Cm64 Cardiac mass QTL 64 5 2.9 38916 D5Rat106 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 5 137693256 177180328 5 - by peak with adj size 5 134356746 173096209 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 133943857 173707219 5 - by peak with adj size 5 127798274 166875058 5 - by peak with adj size 1598862 rat Glom9 Glomerulus QTL 9 2 3.5 38362 D2Rat161 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 2 115620268 160620268 5 - by peak with adj size 2 95764665 140764665 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 95946719 140946719 5 - by peak with adj size 2 92337601 137337601 5 - by peak with adj size 1598863 rat Cm65 Cardiac mass QTL 65 2 2.3 38362 D2Rat161 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 2 115620268 160620268 5 - by peak with adj size 2 95764665 140764665 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 95946719 140946719 5 - by peak with adj size 2 92337601 137337601 5 - by peak with adj size 1598865 rat Bp296 Blood pressure QTL 296 2 2.1 38610 D2Rat143 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 2 103385014 148385014 5 - by peak with adj size 2 83736074 128736074 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 83656855 128656855 5 - by peak with adj size 2 81018907 126018907 5 - by peak with adj size 1598866 rat Bp287 Blood pressure QTL 287 1 5.1 34868 D1Rat45 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 1 137638872 182638872 5 - by peak with adj size 1 123689796 168689796 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 131334152 176334152 5 - by peak with adj size 1 121006655 166006655 5 - by peak with adj size 1598868 rat Mcs12 Mammary carcinoma susceptibility QTL 12 5 1.0E-4 1581988 D5Uwm62 1582038 D5Uwm64 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) Experimental Mammary Neoplasms 1559294;1601189;5684386;6893465 16266982;17404222;21846333;1559294 Mcs23 (sub_region);Mcs24 (sub_region) 5 64739245 65886550 1 - by flanking markers 5 61238737 62299211 1 - by flanking markers 1581629 1581630 WF.WKY-(D5Wox8-D5Uwm62)/Uwm WF.WKY-(D5Uwm63-D5Uwm64)/Uwm 5 60225095 61370302 1 - by flanking markers 5 58973449 60051321 1 - by flanking markers 1598869 rat Memor6 Memory QTL 6 20 3.1 38180 D20Rat27 37792 D20Rat29 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 20 32704500 57791882 2 - by one flank and peak markers 20 28656553 55268282 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 20 30913481 56205956 2 - by one flank and peak markers 20 29244388 54435887 2 - by one flank and peak markers 1598870 rat Bp289 Blood pressure QTL 289 20 2.4 38836 D20Rat37 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598871 rat Memor5 Memory QTL 5 17 5.3 37402 D17Rat78 10348 D17Mit4 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615;7394833 16837653;23469157 2402 Crem Memor18 (sub_region) 17 44407867 87106905 2 - by one flank and peak markers 17 47628673 94800809 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 17 42541872 85446768 2 - by one flank and peak markers 17 40540041 80387013 2 - by one flank and peak markers 1598872 rat Memor14 Memory QTL 14 X 4.5 36735 DXRat32 40522 DXRat98 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 X 101168680 144204814 2 - by one flank and peak markers X 1 118123026 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 101333032 146333032 4 - by one flank marker only X 93956491 138956491 4 - by one flank marker only 1598873 rat Memor2 Memory QTL 2 X 2.5 36111 DXRat8 36952 DXRat11 35331 DXRat25 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581736;1581615 14665699;16837653 X 21859080 44620040 1 - by flanking markers X 41386788 62691414 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 21592623 44320739 1 - by flanking markers X 20990947 41052531 1 - by flanking markers 1598875 rat Bp286 Blood pressure QTL 286 3 2.0 9.0E-4 1582000 D3Mco44 66731 D2Mco36 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure;increased kidney weight Hypotension 1581650;2306800 17028336;19255363 68438;629471;1306721 Oprl1;Rgs19;Rtel1 Bp335 (interacts with) 2 65484323 110484323 4 - by one flank marker only 1582185 1582188 SS.SR-(D3Mco36-D3Got166)/Jr SS.SR-(D3Mco36-D3Mco46)/Jr 1598877 rat Bp285 Blood pressure QTL 285 3 1.5 0.03 1582056 D3Mco81 1582102 D3Mco75 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1581650;2306800 17028336;19255363 3781 Eef1a2 Bp335 (interacts with) 3 138104861 183104861 4 - by one flank marker only 3 122541511 167541511 4 - by one flank marker only 1582185 1582187 SS.SR-(D3Mco36-D3Got166)/Jr SS.SR-(D3Mco24-D3Got130)/Jr 3 128986468 173986468 4 - by one flank marker only 3 120538241 165538241 4 - by one flank marker only 1599689 rat Iddm24 Insulin dependent diabetes mellitus QTL 24 8 4.72 0.001 40246 D8Rat121 39624 D8Rat118 41446 D8Rat119 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased urine glucose level;insulitis Experimental Diabetes Mellitus 1624306;2299158 17389329 8 121647985 126827827 1 - by flanking markers 8 118705293 123876328 1 - by flanking markers 1599674 BBDP.WF-(D8Rat59-D8Sunn1467)/Sunn 8 120870965 127609447 2 - by one flank and peak markers 8 112834440 118649220 2 - by one flank and peak markers 1600358 rat Mamtr5 Mammary tumor resistance QTL 5 5 40716 D5Rat124 39276 D5Rat114 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence;increased tumor growth/size Experimental Mammary Neoplasms;adenocarcinoma 1599390;1643011 17230524;17597107 5 23635353 68635353 4 - by one flank marker only 5 19206257 64206257 4 - by one flank marker only 1599763 SPRD.WKY-(D5Rat190-D5Rat114)/Ibmm 5 18847913 63847913 4 - by one flank marker only 5 18873947 63873947 4 - by one flank marker only 1600360 rat Mcs16 Mammary carcinoma susceptibility QTL 16 1 2.4 39666 D1Rat246 36626 D1Rat15 39666 D1Rat246 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 1 3564603 45053773 1 - by flanking markers 1 2436832 37799020 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 1 1868045 43724576 1 - by flanking markers 1 2244390 43433040 1 - by flanking markers 1600362 rat Mcs19 Mammary carcinoma susceptibility QTL 19 5 2.5 40574 D5Rat196 41560 D5Rat153 40574 D5Rat196 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 5 107265415 111096270 1 - by flanking markers 5 103956411 108590465 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 5 103265614 107119704 1 - by flanking markers 5 99485997 103690167 1 - by flanking markers 1600363 rat Hc6 Hypercalciuria QTL 6 1 2.7 35741 D1Rat32 33830 D1Mit32 37902 D1Rat169 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level;nephrolithiasis Kidney Calculi 1582396 16611718 3562;620771;727801 Rgs10;Ptpre;Nadsyn1 1 202649657 272443364 1 - by flanking markers 1 112148733 250430505 1 - by flanking markers 1598804 WKY.GHS-(D1Rat32-D1Mit32) 1 195598053 265002735 1 - by flanking markers 1 203995416 244113296 2 - by one flank and peak markers 1600365 rat Mcs20 Mammary carcinoma susceptibility QTL 20 9 3.0 35623 D9Rat41 39246 D9Rat63 41772 D9Rat158 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 9 14477917 46933391 1 - by flanking markers 9 8991206 39691794 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 9 15554901 47249201 1 - by flanking markers 9 13533770 42791750 1 - by flanking markers 1600367 rat Mcs15 Mammary carcinoma susceptibility QTL 15 10 4.5 44808 D10Got124 34128 D10Mgh1 35627 D10Rat12 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1581951 16568087 2218 Brca1 10 88338460 107179398 2 - by one flank and peak markers 10 89575059 108822775 2 - by one flank and peak markers 1598797 WF.WKY-(D10Got124-D10Rat187)/Uwm 10 88544136 107545372 2 - by one flank and peak markers 10 85565469 103884409 2 - by one flank and peak markers 1600369 rat Hcas8 Hepatocarcinoma susceptibility QTL 8 16 33652 D16Mit5 40052 D16Rat75 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) increased hepatocyte proliferation;increased hepatoma incidence Experimental Liver Neoplasms 1599590 17079458 16 1 24112769 4 - by one flank marker only 16 1 24132402 4 - by one flank marker only 1599755 F344.BN-(D16Mit5-D16Rat75) 16 1 24228366 4 - by one flank marker only 16 1 22477621 4 - by one flank marker only 1600371 rat Mcs21 Mammary carcinoma susceptibility QTL 21 10 3.0 39102 D10Rat71 37986 D10Rat116 39102 D10Rat71 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) increased mammary adenocarcinoma incidence;increased tumor incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;2302423;1581951 16596452;19052818;16568087 10 29855098 53807373 1 - by flanking markers 10 29541648 54220239 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 10 30021354 54057745 1 - by flanking markers 10 28875650 52200160 1 - by flanking markers 1600373 rat Mamtr6 Mammary tumor resistance QTL 6 18 40096 D18Rat102 39278 D18Rat44 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased incidence of tumors by chemical induction;increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599390;1643011;2302423 17230524;17597107;19052818 18 20030289 86114102 1 - by flanking markers 18 19892650 86863412 1 - by flanking markers 1599760 SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm 18 20285758 87080053 1 - by flanking markers 18 19278901 83218561 1 - by flanking markers 1600374 rat Mcs17 Mammary carcinoma susceptibility QTL 17 1 3.0 38954 D1Rat181 35372 D1Rat88 35372 D1Rat88 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 1 222579288 267579288 4 - by one flank marker only 1 202763018 247763018 4 - by one flank marker only backcross 737895 737962 WKY/Ztm SPRD/Ztm 1 215684498 260684498 4 - by one flank marker only 1 197670404 242670404 4 - by one flank marker only 1600375 rat Mcs22 Mammary carcinoma susceptibility QTL 22 18 3.3 37568 D18Rat55 36638 D18Rat14 36638 D18Rat14 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) increased mammary adenocarcinoma incidence;increased tumor incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;2302423;1581951 16596452;19052818;16568087 18 53346348 67970489 1 - by flanking markers 18 54856551 67024547 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 18 54108375 68819562 1 - by flanking markers 18 52539763 63933058 1 - by flanking markers 1600376 rat Arunc5 Aerobic running capacity QTL 5 3 0.21 40204 D3Rat233 34411 D3Mgh14 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) increased aerobic running capacity 1598978 17179209 3 85198834 130198834 4 - by one flank marker only 3 73863223 118863223 4 - by one flank marker only 1599769 COP.DA-(D3Rat233-D3Mgh14)/Mco 3 78700444 123700444 4 - by one flank marker only 3 73376539 118376539 4 - by one flank marker only 1600378 rat Arunc4 Aerobic running capacity QTL 4 16 0.03 36892 D16Rat12 38444 D16Rat90 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) increased aerobic running capacity 1598978 17179209 620427;1306769 Pdlim3;Tm2d2 16 1084304 85597057 1 - by flanking markers 16 350121 85734479 1 - by flanking markers 1599764 COP.DA-(D16Rat12-D16Rat90)/Mco 16 1090054 86162972 1 - by flanking markers 16 380245 80345693 1 - by flanking markers 1600379 rat Mcs18 Mammary carcinoma susceptibility QTL 18 2 2.6 33822 D2Mit29 37018 D2Rat14 36089 D2Rat4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 2 5396621 61826080 1 - by flanking markers 2 5601528 35247994 2 - by one flank and peak markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 2 5417336 42777046 1 - by flanking markers 2 7887772 42804738 1 - by flanking markers 1600380 rat Niddm70 Non-insulin dependent diabetes mellitus QTL 70 1 3.1 8.0E-4 11.0 34244 D1Mgh10 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 1598974 16783636 1 201410613 246410613 5 - by peak with adj size 1 181780342 226780342 5 - by peak with adj size 1600339 BN.GK-(D1Wox18-D1Got254)/Ox 1 194554354 239554354 5 - by peak with adj size 1 176550523 221550523 5 - by peak with adj size 1600382 rat Edcs3 Endometrial carcinoma susceptibility QTL3 20 3.5 0.003 11207 D20Wox5 37490 D20Rat21 11207 D20Wox5 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 2252;3020;3817;3818;3876 Ddr1;Lta;Tap1;Tap2;Tnf 20 4113091 5240382 1 - by flanking markers 20 1675005 2780205 1 - by flanking markers intercross 737945 737947 BN/Han BDII/Ztm 20 1 25653396 5 - by peak with adj size 20 1 25159026 5 - by peak with adj size 1600384 rat Niddm66 Non-insulin dependent diabetes mellitus QTL 66 1 5.0E-6 9.6 1600324 D1Swe8 43448 D1Got251 10097 D1Smu2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 1599587;2316628;2312611 16951059;19965390;19697080 additive Gluco51 (maps to same region) 1 281763458 282550389 1 - by flanking markers 1 259866528 260641846 1 - by flanking markers 1600342 1600344 F344.GK-(D1Got250-D1Rat90)/Swe F344.GK-(D1Rat175-D1Rat90)/Swe 1 274353782 275138914 1 - by flanking markers 1 252645447 253439819 1 - by flanking markers 1600386 rat Calcic2 Intracellular calcium level QTL 2 12 0.001 34729 D12Mgh5 34373 D12Mgh6 platelet physiology trait (VT:0005464) platelet intracellular calcium level (CMO:0000922) cardiac hypertrophy hypertension 1599588 17261463 2174 Atp2a2 12 33647399 54450796 4 - by one flank marker only 12 29130180 42387195 1 - by flanking markers 1600338 SHR.F344-(D12Mgh5-D12Mgh6)/Snk 12 31723565 52716770 4 - by one flank marker only 12 28064433 46669029 4 - by one flank marker only 1600388 rat Niddm67 Non-insulin dependent diabetes mellitus QTL 67 1 5.84 4.0E-6 19.0 43370 D1Wox8 43454 D1Got254 11060 D1Wox23 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 1598974 16783636 1 220370900 286341689 1 - by flanking markers 1 200882874 264367394 1 - by flanking markers intercross 737972 4889464 BN/Crl GK/Ox 1 213476630 278978026 1 - by flanking markers 1 195804352 257091168 1 - by flanking markers 1600390 rat Niddm64 Non-insulin dependent diabetes mellitus QTL 64 1 0.003 4.0 43443 D1Got247 1600322 D1Swe3 1600318 D1Swe2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 1599587;2312611 16951059;19697080 1310974 Sorcs3 Gluco51 (maps to same region) 1 276009949 276520579 1 - by flanking markers 1 254291806 254810043 1 - by flanking markers 1600344 1600345 F344.GK-(D1Rat175-D1Rat90)/Swe F344.GK-(D1Rat83-D1Rat376)/Swe 1 268570074 269078983 1 - by flanking markers 1 247683763 248192604 1 - by flanking markers 1600391 rat Edcs2 Endometrial carcinoma susceptibility QTL2 12 3.5 0.01 34268 D12Mgh4 41956 D12Arb13 33911 D12Mit6 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 2559;3124 Epo;Muc17 12 10334345 32251246 1 - by flanking markers 12 7382953 27853771 1 - by flanking markers intercross 737945 737947 BN/Han BDII/Ztm 12 8249608 20590080 2 - by one flank and peak markers 12 6833190 17870186 2 - by one flank and peak markers 1600392 rat Bw123 Body weight QTL 123 1 0.001 5.1 34935 D1Rat83 37398 D1Rat175 34935 D1Rat83 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight type 2 diabetes mellitus 1599587;2312611 16951059;19697080 additive Bw85 (maps to same region) 1 251517075 290094216 5 - by peak with adj size 1 229633779 267910886 5 - by peak with adj size 1600345 F344.GK-(D1Rat83-D1Rat376)/Swe 1 244087148 282763074 5 - by peak with adj size 1 223201027 260522016 5 - by peak with adj size 1600394 rat Edcs1 Endometrial carcinoma susceptibility QTL1 11 2.9 0.04 34130 D11Mgh6 33899 D11Mit4 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 2139;1584977 App;Ets2 11 22660494 28704954 2 - by one flank and peak markers 11 19445919 24982397 2 - by one flank and peak markers intercross 737947 737962 BDII/Ztm SPRD/Ztm 11 19016272 25069932 2 - by one flank and peak markers 11 18976208 24697116 2 - by one flank and peak markers 1600395 rat Niddm69 Non-insulin dependent diabetes mellitus QTL 69 1 4.14 2.0E-4 13.0 43370 D1Wox8 43454 D1Got254 70473 D1mD19Mit11 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 1598974 16783636 1 220370900 286341689 1 - by flanking markers 1 200882874 264367394 1 - by flanking markers intercross 737972 4889464 BN/Crl GK/Ox 1 213476630 278978026 1 - by flanking markers 1 195804352 257091168 1 - by flanking markers 1600396 rat Niddm68 Non-insulin dependent diabetes mellitus QTL 68 1 4.97 3.0E-4 13.0 43370 D1Wox8 43454 D1Got254 10580 D1Smu5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 1598974 16783636 1 220370900 286341689 1 - by flanking markers 1 200882874 264367394 1 - by flanking markers 1600339 BN.GK-(D1Wox18-D1Got254)/Ox 1 213476630 278978026 1 - by flanking markers 1 195804352 257091168 1 - by flanking markers 1600397 rat Edcs4 Endometrial carcinoma susceptibility QTL 4 1 2.2 33646 D1Mit4 10674 D1Mgh12 40028 D1Rat301 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 1 248611683 270717037 2 - by one flank and peak markers 1 221868279 247322277 2 - by one flank and peak markers intercross 737947 737962 BDII/Ztm SPRD/Ztm 1 226706329 271706329 5 - by peak with adj size 1 206081677 251081677 5 - by peak with adj size 1600398 rat Edcs5 Endometrial carcinoma susceptibility QTL 5 17 2.2 45485 D17Wox9 33707 D17Mit5 34120 D17Mgh5 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 17 63969458 76361876 1 - by flanking markers 17 65900398 82125463 1 - by flanking markers backcross 737947 737962 BDII/Ztm SPRD/Ztm 17 62195703 74702206 1 - by flanking markers 17 57246723 70852846 1 - by flanking markers 1600399 rat Niddm65 Non-insulin dependent diabetes mellitus QTL 65 1 0.004 3.9 1600320 D1Swe4 41680 D1Rat376 60230 D1Got244 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) type 2 diabetes mellitus 1599587;2312611 16951059;19697080 1305910 Sorcs1 Gluco51 (maps to same region) 1 277075545 277574233 2 - by one flank and peak markers 1 255386328 255970652 2 - by one flank and peak markers 1600346 F344.GK-(D1Swe4-D1Rat85)/Swe 1 269633949 270137485 2 - by one flank and peak markers 1 248746112 249254376 2 - by one flank and peak markers 1641833 rat Alc21 Alcohol consumption QTL 21 4 8.6 1.0E-4 34282 D4Mgh15 34902 D4Rat55 35409 D4Rat34 drinking behavior trait (VT:0001422) ethanol drink intake rate (CMO:0001407) increased alcohol consumption alcohol use disorder;alcohol use disorder 61483;1578304;8662401 9660316;16470346;24611993 3197;70547 Npy;Crhr2 additive 4 55118586 190188644 1 - by flanking markers 4 54879077 127941994 1 - by flanking markers intercross 634380 634381 iP/Iusm iNP/Iusm 4 55375865 125671711 1 - by flanking markers 4 56698790 126192555 1 - by flanking markers 1641885 rat Alcrsp9 Alcohol response QTL 9 7 41106 D7Rat147 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439 15608595 7 31391058 76391058 5 - by peak with adj size 7 27664404 72664404 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 7 31381529 76381529 5 - by peak with adj size 7 24099606 69099606 5 - by peak with adj size 1641887 rat Alcrsp14 Alcohol response QTL 14 15 36313 D15Rat5 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 15 2470818 47470818 5 - by peak with adj size 15 1 44953103 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 15 1 43521446 5 - by peak with adj size 15 1 42356671 5 - by peak with adj size 1641889 rat Colcr6 Colorectal carcinoma resistance QTL 6 15 2.9 0.0126 34222 D15Mgh8 38178 D15Rat63 38178 D15Rat63 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 15 84794264 112515839 1 - by flanking markers 15 80361961 107849649 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 15 81255292 109133904 1 - by flanking markers 15 73690518 99794247 1 - by flanking markers 1641891 rat Alcrsp17 Alcohol response QTL 17 2 35162 D2Rat38 34858 D2Rat69 38054 D2Rat138 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 2 175354307 272813962 1 - by flanking markers 2 155101972 247295816 1 - by flanking markers intercross 1641861 HAS.LAS-(D2Rat53-D2Rat138)/Rar 2 155965557 254121739 1 - by flanking markers 2 149559561 249053267 2 - by one flank and peak markers 1641893 rat Alcrsp7 Alcohol response QTL 7 20 38324 D20Rat32 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 20 1 28385430 5 - by peak with adj size 20 1 27477794 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 20 1 26305996 5 - by peak with adj size 20 1 27339237 5 - by peak with adj size 1641894 rat Alcrsp12 Alcohol response QTL 12 9 39362 D9Rat92 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 9 32091449 77091449 5 - by peak with adj size 9 24535785 69535785 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 9 32385133 77385133 5 - by peak with adj size 9 27468639 72468639 5 - by peak with adj size 1641895 rat Bp298 Blood pressure QTL 298 1 60784 D1Wox29 11359 D1Arb21 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal baroreceptor physiology;decreased mean systemic arterial blood pressure Hypotension;Myocardial Ischemia 1600255;2302408 17327494;19047583 1 131822204 206277202 1 - by flanking markers 1 124614679 187092492 1 - by flanking markers 1600343 SHRSP.WKY-(D1Wox29-D1Arb21)/Izm 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers 1641897 rat Alcrsp1 Alcohol response QTL 1 1 36432 D1Rat35 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 1334439;2317807 15608595;19500156 Alcrsp19 (sub_region) 1 109458992 154458992 5 - by peak with adj size 1 102248992 147248992 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 1 108417193 153417193 5 - by peak with adj size 1 100979852 145979852 5 - by peak with adj size 1641898 rat Colcr4 Colorectal carcinoma resistance QTL4 6 3.71 7.0E-4 35683 D6Rat39 40044 D6Rat154 41064 D6Rat134 intestine integrity trait (VT:0010554) well differentiated malignant colorectal tumor surface area measurement (CMO:0002077) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 6 31405370 75363063 1 - by flanking markers 6 33021033 64955579 2 - by one flank and peak markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 6 21515302 65784818 1 - by flanking markers 6 20338777 62613667 1 - by flanking markers 1641900 rat Alcrsp11 Alcohol response QTL 11 14 39030 D14Rat38 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 14 79794074 115151701 5 - by peak with adj size 14 76579917 112194335 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 14 80049285 115493446 5 - by peak with adj size 14 70053989 104886043 5 - by peak with adj size 1641901 rat Alcrsp6 Alcohol response QTL 6 13 36506 D13Rat32 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 13 62795692 107795692 5 - by peak with adj size 13 55689252 100689252 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 13 57903612 102903612 5 - by peak with adj size 13 52362171 97362171 5 - by peak with adj size 1641902 rat Colcr7 Colorectal carcinoma resistance QTL 7 17 3.35 0.0044 35116 D17Rat53 38348 D17Rat59 35116 D17Rat53 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 17 512253 25386885 1 - by flanking markers 17 7696509 27724805 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 17 519770 23422380 1 - by flanking markers 17 2115149 21881669 1 - by flanking markers 1641903 rat Alcrsp3 Alcohol response QTL 3 5 39186 D5Rat70 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 5 17946863 62946863 5 - by peak with adj size 5 13886258 58886258 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 5 13288888 58288888 5 - by peak with adj size 5 12689285 57689285 5 - by peak with adj size 1641904 rat Alcrsp4 Alcohol response QTL 4 6 35659 D6Rat18 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 6 80668101 125668101 5 - by peak with adj size 6 70874239 115874239 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 6 71206251 116206251 5 - by peak with adj size 6 67262953 112262953 5 - by peak with adj size 1641905 rat Colcr1 Colorectal carcinoma resistance QTL 1 4 4.3 3.0E-4 38118 D4Rat133 38908 D4Rat126 38118 D4Rat133 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 4 1 26562180 4 - by one flank marker only 4 1 26178440 4 - by one flank marker only intercross 737892 1641864 ACI/SegHsd WF/CrCrli 4 1 26654881 4 - by one flank marker only 4 1 29494328 4 - by one flank marker only 1641906 rat Alcrsp16 Alcohol response QTL 16 13 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 intercross 1578696 1578700 LAS1 HAS1 1641908 rat Teswt1 Testicular weight QTL 1 7 3.28 33648 D7Mit5 33969 D7Mit4 testis mass (VT:1000644) both testes wet weight (CMO:0000175) decreased testis weight 1625009;8662361 16651691;24448715 3130 Myc 7 88393619 104437717 1 - by flanking markers 7 85089895 100273797 1 - by flanking markers intercross 629500 LEXF/Stm 7 88365265 103867802 1 - by flanking markers 7 80221299 94811326 1 - by flanking markers 1641910 rat Colcr3 Colorectal carcinoma resistance QTL 3 18 5.02 7.0E-6 38010 D18Rat46 38350 D18Rat38 38010 D18Rat46 intestine integrity trait (VT:0010554) poorly differentiated malignant colorectal tumor number (CMO:0002076);poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 2123 Apc 18 2495834 22914913 1 - by flanking markers 18 2571631 22807391 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 18 2477096 23184414 1 - by flanking markers 18 2249477 22066430 1 - by flanking markers 1641911 rat Alcrsp13 Alcohol response QTL 13 9 36157 D9Rat31 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 9 1217127 46217127 5 - by peak with adj size 9 1 39963583 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 9 2355722 47355722 5 - by peak with adj size 9 1 43718459 5 - by peak with adj size 1641912 rat Alcrsp18 Alcohol response QTL 18 5 39186 D5Rat70 35651 D5Rat37 39402 D5Rat139 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 5 40446731 151220567 1 - by flanking markers 5 36386126 148460381 1 - by flanking markers intercross 1641854 HAS.LAS-(D5Rat70-D5Rat37)/Rar 5 35788756 147487820 1 - by flanking markers 5 35189153 141643988 1 - by flanking markers 1641913 rat Colcr2 Colorectal carcinoma resistance QTL 2 15 6.57 0.0197 38922 D15Rat38 37106 D15Rat31 37106 D15Rat31 intestine integrity trait (VT:0010554) colorectal tumor number (CMO:0001794);poorly differentiated malignant colorectal tumor number (CMO:0002076) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 15 2310393 30216604 1 - by flanking markers 15 2306220 25410881 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 15 2327877 26288802 1 - by flanking markers 15 2266368 22711984 1 - by flanking markers 1641915 rat Colcr9 Colorectal carcinoma resistance QTL 9 20 2.97 0.0024 35212 D20Rat13 33876 D20Mit4 35212 D20Rat13 intestine integrity trait (VT:0010554) benign colorectal tumor number (CMO:0001795) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 20 27567584 36993999 1 - by flanking markers 20 1 32560683 4 - by one flank marker only intercross 737892 1641864 ACI/SegHsd WF/CrCrli 20 2999707 47999707 5 - by peak with adj size 20 1530655 46530655 5 - by peak with adj size 1641917 rat Colcr5 Colorectal carcinoma resistance QTL 5 6 3.18 9.0E-4 34098 D6Mgh3 37076 D6Rat1 39052 D6Rat101 intestine integrity trait (VT:0010554) benign colorectal tumor number (CMO:0001795) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 6 136507025 153672040 1 - by flanking markers 6 127683728 144152572 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 6 127286494 144745573 1 - by flanking markers 6 122549046 137801795 1 - by flanking markers 1641918 rat Alcrsp15 Alcohol response QTL 16 12 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 intercross 1578696 1578700 LAS1 HAS1 1641919 rat Alc22 Alcohol consumption QTL 22 4 5.0E-4 37438 D4Rat119 34902 D4Rat55 drinking behavior trait (VT:0001422) ethanol drink intake rate (CMO:0001407) increased alcohol consumption alcohol use disorder 1578304;1624272;8662401;7394775 16470346;17451403;24611993;23312492 2092;3197;3729;68368;70547;735049;1307836;1308501;1310949;1311418 Akr1b1;Npy;Snca;Grid2;Crhr2;Dgki;Zfp212;Ppm1k;Sos1;Baiap1 additive Bw126 (sub_region) 4 145188644 190188644 4 - by one flank marker only 4 62832008 127941994 1 - by flanking markers 1641877 NP.P-(D4Rat119-D4Rat55)/Iusm 4 62947687 125671711 1 - by flanking markers 4 81192555 126192555 4 - by one flank marker only 1641920 rat Colcs1 Colorectal carcinoma susceptibility QTL 1 5 2.99 0.0055 39406 D5Rat205 35823 D5Rat50 39250 D5Rat74 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 5 132161806 177161806 4 - by one flank marker only intercross 737892 1641864 ACI/SegHsd WF/CrCrli 5 128687766 173687766 4 - by one flank marker only 5 121846814 166846814 4 - by one flank marker only 1641922 rat Alcrsp8 Alcohol response QTL 8 5 39186 D5Rat70 39402 D5Rat139 39186 D5Rat70 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 5 40446731 74918556 1 - by flanking markers 5 36386126 71377566 1 - by flanking markers intercross 1578696 1578700 LAS1 HAS1 5 35788756 70742105 1 - by flanking markers 5 35189153 68564008 1 - by flanking markers 1641923 rat Colcr8 Colorectal carcinoma resistance QTL 8 18 3.1 0.0014 38350 D18Rat38 37738 D18Rat57 37738 D18Rat57 intestine integrity trait (VT:0010554) poorly differentiated malignant colorectal tumor number (CMO:0002076) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 18 22914726 53100658 1 - by flanking markers 18 22807203 54605912 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 18 23184227 53861431 1 - by flanking markers 18 22066242 52293055 1 - by flanking markers 1641925 rat Alcrsp2 Alcohol response QTL 2 2 35162 D2Rat38 38054 D2Rat138 35313 D2Rat53 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 2 175354307 256283467 1 - by flanking markers 2 155101972 230157845 1 - by flanking markers intercross 1578696 1578700 LAS1 HAS1 2 155965557 237742948 1 - by flanking markers 2 149559561 221167075 1 - by flanking markers 1641926 rat Teswt2 Testicular weight QTL 2 1 2.82 33753 D1Mit5 10445 D1Wox25 testis mass (VT:1000644) both testes wet weight (CMO:0000175) decreased testis weight 1625009 16651691 1 222606650 266214325 1 - by flanking markers 1 202790380 247790380 4 - by one flank marker only intercross 629500 LEXF/Stm 1 215711860 258765521 1 - by flanking markers 1 197697768 238755659 1 - by flanking markers 1641927 rat Alcrsp10 Alcohol response QTL 10 11 35323 D11Rat24 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439 15608595 11 12960007 57960007 5 - by peak with adj size 11 9165656 54165656 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 11 9351274 54351274 5 - by peak with adj size 11 8436674 53436674 5 - by peak with adj size 1641928 rat Alcrsp5 Alcohol response QTL 5 12 39332 D12Rat52 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 12 20209592 54450796 5 - by peak with adj size 12 13948769 46782294 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 12 18342477 52716770 5 - by peak with adj size 12 12812385 46669029 5 - by peak with adj size 1642290 rat Bp299 Blood pressure QTL 299 10 1642083 D10Mco88 1642081 D10Mco89 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1599269;1642602 17218081;17893371 69069;621743 Ccl5;Ddx52 Bp300 (sub_region);Bp301 (sub_region);Bp302 (sub_region) 10 70280918 71638303 1 - by flanking markers 10 71513116 72685167 1 - by flanking markers intercross 1642272 SS.LEW-(D10Mco84-D10Got93)/Mco 10 70647089 71727943 1 - by flanking markers 10 68230134 69282520 1 - by flanking markers 1642976 rat Bp301 Blood pressure QTL 301 10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 1642602;2303163 17893371;8829824 727916;1309875;1585229 Rffl;Lig3;LOC688779 Bp299 (sub_region) intercross 1642968 SS.LEW-(D10Mco84-D10Rat58)/Mco 1642980 rat Bp300 Blood pressure QTL 300 10 44761 D10Got88 66492 D10Mco62 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 1642602;2303163 17893371;8829824 3647;619957;620441;1303147;1303200;1566204;1596171 Ccl3;Wfdc18;Ccl4;Wfdc21;Ccl6;Heatr6;LOC689133 Bp299 (sub_region) 10 70433545 70763527 1 - by flanking markers 10 71662573 72063491 1 - by flanking markers intercross 1642969 SS.LEW-(D10Mco84-D10Mco134)/Mco 10 70800069 112626471 4 - by one flank marker only 10 68383129 107211142 4 - by one flank marker only 1642982 rat Bp302 Blood pressure QTL 302 10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 1642602;2303163 17893371;8829824 71048;620757;1310708;1561538;1564411;1582982;1582997;1583007;1584095;1584109;1588811 Ap2b1;Pex12;Fndc8;Slfn14;Slfn3;Gsta4l1;LOC688910;Slfn1;LOC688871;LOC688857;LOC688477 Bp299 (sub_region) intercross 1642972 SS.LEW-(D10Mco84-D10Mco143)/Mco 1643004 rat Pain2 Pain QTL 2 7 1.0 37382 D7Rat113 35264 D7Rat18 mechanical nociception trait (VT:0002734) self mutilation severity score (CMO:0002145) abnormal pain threshold Pain 1643003 17560719 7 12498167 106942302 1 - by flanking markers 7 10973606 103612887 1 - by flanking markers intercross 1581623 1581640 LA/Humd HA/Humd 7 12328467 106995532 1 - by flanking markers 7 9462246 98011544 1 - by flanking markers 1643006 rat Pain1 Pain QTL 1 2 3.63 0.005 26.0 36145 D2Rat73 36659 D2Rat17 mechanical nociception trait (VT:0002734) self mutilation severity score (CMO:0002145) abnormal pain threshold Pain 1643003 17560719 Pain1_m (maps to syntenic region) 2 45399390 67058673 1 - by flanking markers 2 26101088 48244982 1 - by flanking markers intercross 1581623 1581640 LA/Humd HA/Humd 2 26267995 48676716 1 - by flanking markers 2 26999571 48268661 1 - by flanking markers 2289982 rat Bp303 Blood pressure QTL 303 10 36203 D10Rat27 35513 D10Rat24 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 628510;1643425 11641286;18175179 Bp304 (sub_region);Bp305 (sub_region) 10 74127825 78195122 1 - by flanking markers 10 77091834 79229233 1 - by flanking markers intercross 1641871 SS.MNS-(D10Mco62-D10Mco31)/Jr 10 75983662 78343192 1 - by flanking markers 10 73452992 75632053 1 - by flanking markers 2289983 rat Bp304 Blood pressure QTL 304 10 39500 D10Rat193 38286 D10Rat112 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1643425 18175179 Bp303 (sub_region) 10 74001821 76667915 1 - by flanking markers 10 77219626 77679394 1 - by flanking markers intercross 2289827 SS.MNS-(D10Mco30-D10Mco31)/Jr 10 76109491 76802057 1 - by flanking markers 10 73579541 74119158 1 - by flanking markers 2289985 rat Bp305 Blood pressure QTL 305 10 1642087 D10Mco84 39500 D10Rat193 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1643425 18175179 Bp303 (sub_region) 10 69542746 74002046 1 - by flanking markers 10 70757255 77219852 1 - by flanking markers intercross 2289819 SS.MNS-(D10Mco62-D10Got99)/Mco 10 69910832 76109716 1 - by flanking markers 10 67502108 73579767 1 - by flanking markers 2290005 rat Mcs24 Mammary carcinoma susceptibility QTL 24 5 69527 D5Uwm29 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1601189 17404222 1305229;1305465 Frmpd1;Fbxo10 Mcs12 (sub_region) 5 72784931 117784931 4 - by one flank marker only 5 70181758 115181758 4 - by one flank marker only 61105 737908 WKY/NHsd WF/NHsd 5 68838385 113838385 4 - by one flank marker only 5 64719390 109719390 4 - by one flank marker only 2290007 rat Mcs23 Mammary carcinoma susceptibility QTL 23 5 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1601189 17404222 1305465 Fbxo10 Mcs12 (sub_region) 61105 737908 WKY/NHsd WF/NHsd 2290372 rat Gluco33 Glucose level QTL 33 7 2.71 38788 D7Rat72 41252 D7Rat149 35178 D7Rat47 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Experimental Diabetes Mellitus 1626640;2326163 17213368;20530722 7 14768165 36408841 1 - by flanking markers 7 13170547 32454105 1 - by flanking markers intercross 1357181 1357191 CDR/Ygl CDS/Ygl 7 26508887 36346595 2 - by one flank and peak markers 7 20555705 29891047 2 - by one flank and peak markers 2290374 rat Gluco32 Glucose level QTL 32 4 6.27 39194 D4Rat115 35625 D4Rat14 41888 D4Rat282 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) decreased circulating insulin level;increased circulating glucose level Experimental Diabetes Mellitus 1626640;2326163 17213368;20530722 621465 Ica1 Gluco61 (maps to same region) 4 34996009 44024417 1 - by flanking markers 4 34206019 41729771 1 - by flanking markers intercross 1357181 1357191 CDR/Ygl CDS/Ygl 4 35138860 43414792 1 - by flanking markers 4 37177950 44463908 1 - by flanking markers 2290375 rat Gluco34 Glucose level QTL 34 X 2.75 36111 DXRat8 33575 DXMit5 33575 DXMit5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Experimental Diabetes Mellitus 1626640;2326163 17213368;20530722 X 21859080 44765347 1 - by flanking markers X 41386788 62894306 1 - by flanking markers intercross 1357181 1357191 CDR/Ygl CDS/Ygl X 21592623 44468300 1 - by flanking markers X 20990947 41203591 1 - by flanking markers 2290393 rat Uae37 Urinary albumin excretion QTL 37 6 1.0E-4 38608 D6Rat106 36191 D6Rat6 36990 D6Rat12 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria;increased urine protein level Albuminuria 1642911 17953514 6 78348236 132488565 1 - by flanking markers 6 68036028 123455207 1 - by flanking markers intercross 1641831 MWF-Chr 6SHR/Rkb 6 68781170 147991367 2 - by one flank and peak markers 6 65531555 140994061 2 - by one flank and peak markers 2290448 rat Scl54 Serum cholesterol level QTL 54 5 2.93 40330 D5Rat130 33680 D5Mit13 33985 D5Mit11 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 5 36590997 140429983 1 - by flanking markers 5 32701659 138272129 1 - by flanking markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 5 31926122 136640934 1 - by flanking markers 5 31663789 131345958 1 - by flanking markers 2290450 rat Scl57 Serum cholesterol level QTL 57 9 4.15 37604 D9Rat76 41600 D9Rat110 33999 D9Mit5 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 9 40929725 102148004 1 - by flanking markers 9 33496794 94217673 1 - by flanking markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 9 41261034 102531865 1 - by flanking markers 9 36962359 95410867 1 - by flanking markers 2290451 rat Scl58 Serum cholesterol level QTL 58 11 3.48 41734 D11Rat101 34150 D11Mgh5 34130 D11Mgh6 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 SCL37_H (maps to syntenic region) 11 15035502 47637447 1 - by flanking markers 11 12965570 43157054 1 - by flanking markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 11 11367306 44444347 1 - by flanking markers 11 12831046 25121472 2 - by one flank and peak markers 2290452 rat Scl56 Serum cholesterol level QTL 56 3 2.26 35795 D3Rat26 37510 D3Rat100 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 SCL103_H (maps to syntenic region) 3 1 101798901 2 - by one flank and peak markers 3 1 90573782 2 - by one flank and peak markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 3 1 95176874 2 - by one flank and peak markers 3 1 91609953 2 - by one flank and peak markers 2290453 rat Scl55 Serum cholesterol level QTL 55 2 2.83 38976 D2Rat124 36466 D2Rat34 40292 D2Rat196 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 2 45317613 161740132 1 - by flanking markers 2 96755420 141755420 4 - by one flank marker only intercross;intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 2 26186097 142053534 1 - by flanking markers 2 26917817 136917119 1 - by flanking markers 2292216 rat Bw80 Body weight QTL 80 1 3.23 0.0019 35551 D1Rat117 34971 D1Rat81 36960 D1Rat76 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Body Weight Changes 1626643;2312611 16700878;19697080 Bw85 (maps to same region) 1 240604381 272245383 1 - by flanking markers 1 219629755 250119874 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 233490105 264802994 1 - by flanking markers 1 213533809 243914901 1 - by flanking markers 2292218 rat Kidm35 Kidney mass QTL 35 1 38854 D1Rat168 36960 D1Rat76 35551 D1Rat117 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight Body Weight Changes 1626643 16700878 1 224224750 252243871 1 - by flanking markers 1 204621918 230411453 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 217372257 244992610 1 - by flanking markers 1 199368955 224569684 1 - by flanking markers 2292220 rat Bp306 Blood pressure QTL 306 1 3.47 8.7E-4 35311 D1Rat54 34971 D1Rat81 38854 D1Rat168 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1626643 16700878 Bp42 (maps to same region) 1 181904317 272245383 1 - by flanking markers 1 167931220 250119874 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 174905700 264802994 1 - by flanking markers 1 164310393 243914901 1 - by flanking markers 2292222 rat Bp307 Blood pressure QTL 307 1 3.06 0.0014 35311 D1Rat54 35551 D1Rat117 38854 D1Rat168 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1626643 16700878 1 181904317 240604513 1 - by flanking markers 1 167931220 219629888 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 174905700 233490237 1 - by flanking markers 1 164310393 213533942 1 - by flanking markers 2292232 rat Pur16 Proteinuria QTL 16 13 17.2 45025 D13Got8 34833 D13Rat19 41978 D13Arb5 urine total protein amount (VT:0000032) urine protein level (CMO:0000591) increased urine protein level proteinuria 2292230 18064521 71024 Actr3 Pur1 (sub_region) 13 46171139 52282100 1 - by flanking markers 13 37191203 43437366 1 - by flanking markers backcross 61118 61119 BUF/Mna WKY/NCrlCrlj 13 41060057 47227923 1 - by flanking markers 13 36155723 41961389 1 - by flanking markers 2292436 rat Bp310 Blood pressure QTL 310 10 1579093 D10Chm14 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;6480214;7421500 18398331;22124177;23814039 1307333 Abca8a Bp256 (interacts with);Bp257 (interacts with);Bp258 (interacts with);Bp270 (interacts with);Bp279 (interacts with);Bp280 (sub_region);Bp312 (interacts with);Bp315 (interacts with);Bp345 (interacts with);Bp346 (interacts with);Bp347 (interacts with);Bp361 (interacts with);Bp365 (interacts with);Bp369 (interacts with);Bp38 (interacts with) 10 97793396 112200500 4 - by one flank marker only 10 99233734 99588446 1 - by flanking markers intercross 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd 10 98079221 112626471 4 - by one flank marker only 10 94759759 107211142 4 - by one flank marker only 2292438 rat Bp311 Blood pressure QTL 311 10 44781 D10Got112 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238 18398331 Bp281 (sub_region) 10 78816241 112200500 4 - by one flank marker only 10 79857808 99588446 1 - by flanking markers intercross 2292386 SS.LEW-(D10Chm155-D10Rat127)/Ayd 10 78970279 112626471 4 - by one flank marker only 10 76246085 107211142 4 - by one flank marker only 2292439 rat Bp309 Blood pressure QTL 309 10 1578839 D10Chm79 1579166 D10Chm3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;6480214;1559293 18398331;22124177;16286573 2364;620683;1308349;1561541 Cltc;Rps6kb1;Trim37;Prr11 Bp279 (sub_region);Bp308 (interacts with) 10 73626664 75641342 1 - by flanking markers 10 74524802 75428239 1 - by flanking markers intercross 2292387 SS.LEW-(D10Chm224-D10Chm259)/Ayd 10 73727917 74459500 1 - by flanking markers 10 71115217 71966743 1 - by flanking markers 2292440 rat Bp312 Blood pressure QTL 312 10 1578931 D10Chm171 1578994 D10Chm147 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;7421500;8657382 18398331;23814039;23773896 620455;1308645;1561538;1564411;1583007 Slfn4;Slfn2;Slfn14;Slfn3;Slfn1 Bp282 (sub_region);Bp310 (interacts with) 10 69797667 70215618 1 - by flanking markers 10 71032534 71447820 1 - by flanking markers intercross 2292388 SS.LEW-(D10Chm246-D10Chm257)/Ayd 10 70166960 70581793 1 - by flanking markers 10 67750049 68164786 1 - by flanking markers 2292441 rat Bp308 Blood pressure QTL 308 10 1579031 D10Chm4 1578891 D10Chm29 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;6480214 18398331;22124177 708563;735028;1305204;1310306;1588724;1592081 Tspoap1;Ppm1e;Rnf43;Mtmr4;LOC689764;Mpo Bp279 (sub_region);Bp309 (interacts with) 10 30002634 75002634 4 - by one flank marker only 10 31098661 76098661 4 - by one flank marker only intercross 2292390 SS.LEW-(D10Rat194-D10Chm243)/Ayd 10 30099909 75099909 4 - by one flank marker only 10 27606468 72606468 4 - by one flank marker only 2292589 rat Emca10 Estrogen-induced mammary cancer QTL 10 6 0.048 37142 D6Rat80 41266 D6Rat146 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 2292503 18420736 6 1111498 46111498 4 - by one flank marker only 6 1301952 46301952 4 - by one flank marker only 2292564 ACI.COP-(D6Rat80-D6Rat146)/Shul 6 1120393 46120393 4 - by one flank marker only 6 16536140 61536140 4 - by one flank marker only 2292591 rat Esta4 Estrogen-induced thymic atrophy QTL 4 3 39050 D3Rat130 37980 D3Rat114 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) thymus atrophy thymoma 2292503 18420736 3 55227530 160347840 1 - by flanking markers 3 44551252 149496698 1 - by flanking markers 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul 3 48561928 155263151 1 - by flanking markers 3 47233211 147415807 1 - by flanking markers 2292613 rat Ept16 Estrogen-induced pituitary tumorigenesis QTL 16 3 8.3 35451 D3Rat21 39050 D3Rat130 35795 D3Rat26 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept2 (maps to same region) 3 55227748 121789152 1 - by flanking markers 3 44551542 110215186 1 - by flanking markers intercross 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul 3 48562146 115249962 1 - by flanking markers 3 47233430 110362260 1 - by flanking markers 2292615 rat Ept17 Estrogen-induced pituitary tumorigenesis QTL 17 3 6.7 11.0 41830 D3Rat277 34347 D3Mgh16 34186 D3Mgh9 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept6 (maps to same region) 3 11361817 31948244 1 - by flanking markers 3 6373454 22341164 1 - by flanking markers intercross 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul 3 571136 6000866 2 - by one flank and peak markers 3 6537645 10778823 2 - by one flank and peak markers 2292616 rat Ept15 Estrogen-induced pituitary tumorigenesis QTL 15 6 4.4 1357998 D6Rat150 35683 D6Rat39 37142 D6Rat80 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept1 (maps to same region) 6 8018013 31405507 1 - by flanking markers 6 1 8184962 2 - by one flank and peak markers intercross 2292564 ACI.COP-(D6Rat80-D6Rat146)/Shul 6 8083222 21515439 1 - by flanking markers 6 9843312 20338915 1 - by flanking markers 2292617 rat Ept18 Estrogen-induced pituitary tumorigenesis QTL 18 10 3.9 7.0 35256 D10Rat11 36203 D10Rat27 33690 D10Mit7 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept9 (maps to same region) 10 74127968 99184058 1 - by flanking markers 10 77092169 100633512 1 - by flanking markers intercross 2292567 ACI.COP-(D10Mgh20-D10Rat4)/Shul 10 75983805 99492217 1 - by flanking markers 10 73453136 96120911 1 - by flanking markers 2293083 rat Iddm25 Insulin dependent diabetes mellitus QTL 25 1 4.18 10951 D1Mit13 36960 D1Rat76 11060 D1Wox23 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 2870;2916 Igf2;Ins2 Iddm10 (maps to same region);Iddm9 (maps to same region) 1 205649453 252243871 1 - by flanking markers 1 186471692 230411453 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 1 198655722 244992610 1 - by flanking markers 1 181829673 224569684 1 - by flanking markers 2293084 rat Iddm26 Insulin dependent diabetes mellitus QTL 26 2 2.9 36091 D2Rat44 36876 D2Rat88 42110 D2Arb16 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106;10043114 1446803;19168599;24920533 1307992 Ptpn22 Iddm3 (maps to same region) 2 208261410 248335979 1 - by flanking markers 2 181710214 222281918 1 - by flanking markers intercross 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 2 188838511 228984665 1 - by flanking markers 2 174930955 213594495 1 - by flanking markers 2293085 rat Iddm29 Insulin dependent diabetes mellitus QTL 29 6 7.66 34098 D6Mgh3 44208 D6Got167 37076 D6Rat1 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 Iddm28 (interacts with);Iddm8 (maps to same region) 6 136507025 156159363 1 - by flanking markers 6 127683728 146651354 1 - by flanking markers 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 6 127286494 147249902 1 - by flanking markers 6 122549046 140286318 1 - by flanking markers 2293086 rat Iddm30 Insulin dependent diabetes mellitus QTL 30 12 3.82 44938 D12Got11 36101 D12Rat15 37272 D12Rat28 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 3447 Ptpn11 12 12281726 33889801 1 - by flanking markers 12 8901318 29369703 1 - by flanking markers intercross 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 12 10175889 31975590 1 - by flanking markers 12 8449490 28302290 1 - by flanking markers 2293087 rat Iddm27 Insulin dependent diabetes mellitus QTL 27 3 2.68 35799 D3Rat24 37980 D3Rat114 36882 D3Rat7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 3 108753156 160347840 1 - by flanking markers 3 96506745 149496698 1 - by flanking markers intercross 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 3 102152812 155263151 1 - by flanking markers 3 97551417 147415807 1 - by flanking markers 2293088 rat Iddm28 Insulin dependent diabetes mellitus QTL 28 6 5.21 36729 D6Rat23 42786 D6Rat169 38494 D6Rat88 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 Iddm29 (interacts with) 6 75798693 84567798 1 - by flanking markers 6 65393789 74436856 1 - by flanking markers intercross 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 6 66222612 75023308 1 - by flanking markers 6 63040562 71636266 1 - by flanking markers 2293089 rat Iddm31 Insulin dependent diabetes mellitus QTL 31 14 4.7 36536 D14Rat1 33551 D14Mit6 36536 D14Rat1 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140);blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2299158;2303106;2293011 19168599;1446803 14 4830815 19816660 1 - by flanking markers 14 4895894 19800418 1 - by flanking markers intercross 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 14 4833233 19909932 1 - by flanking markers 14 3813074 18274691 1 - by flanking markers 2293140 rat Bp313 Blood pressure QTL 313 1 66611 D1Mco36 2292719 D1Mco101 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2291850;9685377 18324438;25231251 69305 Nr2f2 Bp314 (interacts with);Bp375 (sub_region);Bp376 (sub_region);Bp94 (sub_region) 1 130267716 175267716 4 - by one flank marker only 1 122991895 167991895 4 - by one flank marker only intercross 2292653 SS.LEW-(D1Mco36-D1Mco101)/Mco 1 129208943 174208943 4 - by one flank marker only 1 121833674 166833674 4 - by one flank marker only 2293142 rat Bp314 Blood pressure QTL 314 1 2292749 D1Mco85 35016 D1Rat106 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2291850 18324438 Bp313 (interacts with);Bp94 (sub_region) 1 101282094 146282094 4 - by one flank marker only 1 94471673 139471673 4 - by one flank marker only intercross 2292652 SS.LEW-(D1Mco85-D1Rat49)/Mco 1 100354344 145354344 4 - by one flank marker only 1 92184926 137184926 4 - by one flank marker only 2293341 rat Glom15 Glomerulus QTL 15 13 9.1 36506 D13Rat32 34945 D13Rat51 39262 D13Rat86 kidney glomerulus integrity trait (VT:0010546) kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269) glomerulonephritis glomerulonephritis;nephritis 2293335;2325762 16482158;20488952 71069 Fcgr2a 13 85295639 113387165 1 - by flanking markers 13 78189125 106076220 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 13 80403559 108770687 1 - by flanking markers 13 74862117 101339893 1 - by flanking markers 2293343 rat Glom16 Glomerulus QTL 16 16 7.4 39456 D16Rat88 34894 D16Rat29 41618 D16Rat82 kidney glomerulus integrity trait (VT:0010546) kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269) glomerulonephritis glomerulonephritis;nephritis 2293335;2293336;2325762 16482158;18443593;20488952 2945 Jund 16 1534408 48959444 1 - by flanking markers 16 819225 49333382 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 16 1550187 49247447 1 - by flanking markers 16 832236 46053497 1 - by flanking markers 2293642 rat Bss37 Bone structure and strength QTL 37 5 4.64 1.0E-4 35545 D5Rat28 39478 D5Rat204 42185 D5Arb1 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) abnormal bone structure osteoporosis 2293455 18158281 5 129313212 160966475 1 - by flanking markers 5 126963761 157597184 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 5 125455818 157225114 1 - by flanking markers 5 120740824 151018848 1 - by flanking markers 2293644 rat Bmd29 Bone mineral density QTL 29 7 5.4 1.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 7 78253693 123378833 1 - by flanking markers 7 74658964 120536775 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293646 rat Bss25 Bone structure and strength QTL 25 10 10.96 1.0E-4 36283 D10Rat15 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 10 72743019 112200500 5 - by peak with adj size 10 74167134 110718848 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 73008136 112626471 5 - by peak with adj size 10 69738412 107211142 5 - by peak with adj size 2293648 rat Bmd31 Bone mineral density QTL 31 17 4.5 1.0E-4 38150 D17Rat80 34827 D17Rat12 34827 D17Rat12 femur size trait (VT:1000369) femoral neck cortical cross-sectional area (CMO:0001702) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 17 6945553 29605354 1 - by flanking markers 17 10044240 33277509 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 17 4716067 27691136 1 - by flanking markers 17 4354487 27028127 1 - by flanking markers 2293650 rat Bss31 Bone structure and strength QTL 31 6 5.05 1.0E-4 35653 D6Rat42 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 6 8559248 53559248 5 - by peak with adj size 6 1 42401411 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 43665660 5 - by peak with adj size 6 1 42487980 5 - by peak with adj size 2293652 rat Bmd22 Bone mineral density QTL 22 10 4.9 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293654 rat Bss30 Bone structure and strength QTL 30 1 32.65 1.0E-4 36460 D1Rat69 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293655 rat Bss36 Bone structure and strength QTL 36 1 10.66 1.0E-4 37902 D1Rat169 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) abnormal bone structure osteoporosis 2293455 18158281 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2293656 rat Bss28 Bone structure and strength QTL 28 6 6.79 1.0E-4 35653 D6Rat42 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure osteoporosis 2293455 18158281 6 8559248 53559248 5 - by peak with adj size 6 1 42401411 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 43665660 5 - by peak with adj size 6 1 42487980 5 - by peak with adj size 2293658 rat Bmd23 Bone mineral density QTL 23 18 7.3 1.0E-4 38146 D18Rat50 34975 D18Rat13 34975 D18Rat13 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 18 52220612 67678102 1 - by flanking markers 18 53847682 66720186 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 53033494 68524999 1 - by flanking markers 18 51464733 63636873 1 - by flanking markers 2293659 rat Bmd35 Bone mineral density QTL 35 4 4.5 1.0E-4 37850 D4Rat104 36562 D4Rat72 36562 D4Rat72 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) increased bone mineral density osteoporosis 2293456 18282130 4 201377951 247013637 1 - by flanking markers 4 140454608 186104310 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 4 136908430 182878540 1 - by flanking markers 4 137755016 181392681 1 - by flanking markers 2293661 rat Bss50 Bone structure and strength QTL 50 18 4.64 3.0E-4 37578 D18Rat65 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 18 1 37966407 5 - by peak with adj size 18 1 34745192 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 1 38195967 5 - by peak with adj size 18 1 34291613 5 - by peak with adj size 2293663 rat Bss33 Bone structure and strength QTL 33 10 9.34 1.0E-4 36283 D10Rat15 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 10 72743019 112200500 5 - by peak with adj size 10 74167134 110718848 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 73008136 112626471 5 - by peak with adj size 10 69738412 107211142 5 - by peak with adj size 2293664 rat Bmd28 Bone mineral density QTL 28 17 5.1 1.0E-4 38150 D17Rat80 34827 D17Rat12 34827 D17Rat12 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 17 6945553 29605354 1 - by flanking markers 17 10044240 33277509 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 17 4716067 27691136 1 - by flanking markers 17 4354487 27028127 1 - by flanking markers 2293666 rat Bmd38 Bone mineral density QTL 38 5 4.4 40562 D5Rat187 35132 D5Rat3 femur size trait (VT:1000369) femoral neck cortical cross-sectional area (CMO:0001702) increased bone mineral density osteoporosis 2293456 18282130 5 13440622 58440622 4 - by one flank marker only 5 8464827 40137122 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 5 8632285 53632285 4 - by one flank marker only 5 8948228 53948228 4 - by one flank marker only 2293667 rat Bss42 Bone structure and strength QTL 42 7 7.25 1.0E-4 35919 D7Rat23 lumbar vertebra size trait (VT:0010518) lumbar vertebra cross-sectional area (CMO:0001689) abnormal bone strength osteoporosis 2293455 18158281 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293669 rat Bmd33 Bone mineral density QTL 33 10 4.5 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur strength trait (VT:0010010) femoral neck polar moment of inertia (CMO:0001670) increased bone mineral density osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293671 rat Bss44 Bone structure and strength QTL 44 2 10.97 1.0E-4 39874 D2Rat198 37330 D2Rat181 40462 D2Rat280 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) abnormal bone strength osteoporosis 2293455 18158281 2 62186976 173967037 1 - by flanking markers 2 42874025 153832507 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 43141290 154583160 1 - by flanking markers 2 43162366 148478373 1 - by flanking markers 2293673 rat Bss27 Bone structure and strength QTL 27 1 18.63 1.0E-4 36460 D1Rat69 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293674 rat Bss39 Bone structure and strength QTL 39 1 7.1 1.0E-4 37902 D1Rat169 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) abnormal bone structure osteoporosis 2293455 18158281 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2293676 rat Bmd19 Bone mineral density QTL 19 2 10.7 1.0E-4 39874 D2Rat198 40462 D2Rat280 40462 D2Rat280 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 2 62186976 133866167 1 - by flanking markers 2 42874025 87874025 4 - by one flank marker only intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 43141290 114164944 1 - by flanking markers 2 43162366 111362592 1 - by flanking markers 2293677 rat Bss41 Bone structure and strength QTL 41 1 9.38 1.0E-4 36460 D1Rat69 lumbar vertebra size trait (VT:0010518) lumbar vertebra cross-sectional area (CMO:0001689) abnormal bone strength osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293678 rat Bss24 Bone structure and strength QTL 24 7 6.71 1.0E-4 35919 D7Rat23 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293679 rat Bmd30 Bone mineral density QTL 30 10 3.5 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293680 rat Bss40 Bone structure and strength QTL 40 10 5.66 1.0E-4 33630 D10Mit17 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) abnormal bone structure osteoporosis 2293455 18158281 10 1 35358590 5 - by peak with adj size 10 1 35460104 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 1 35538813 5 - by peak with adj size 10 1 35225947 5 - by peak with adj size 2293682 rat Bmd24 Bone mineral density QTL 24 2 8.9 1.0E-4 39874 D2Rat198 40462 D2Rat280 40462 D2Rat280 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 2 62186976 133866167 1 - by flanking markers 2 42874025 87874025 4 - by one flank marker only intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 43141290 114164944 1 - by flanking markers 2 43162366 111362592 1 - by flanking markers 2293684 rat Bmd26 Bone mineral density QTL 26 12 4.4 2.0E-4 40408 D12Rat91 39060 D12Rat30 40408 D12Rat91 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 12 19953929 40290100 1 - by flanking markers 12 16387455 34112949 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 12 17960865 38409001 1 - by flanking markers 12 15872653 32974238 1 - by flanking markers 2293685 rat Bmd21 Bone mineral density QTL 21 7 4.2 3.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 7 78253693 123378833 1 - by flanking markers 7 74658964 120536775 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293686 rat Bmd36 Bone mineral density QTL 36 15 7.4 1.0E-4 40084 D15Rat117 40882 D15Rat97 40084 D15Rat117 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) increased bone mineral density osteoporosis 2293456 18282130 15 43570947 82573380 1 - by flanking markers 15 38542355 78048493 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 39749557 79033707 1 - by flanking markers 15 33611058 71477291 1 - by flanking markers 2293687 rat Bss26 Bone structure and strength QTL 26 13 4.6 1.0E-4 39262 D13Rat86 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 13 75695127 118718031 5 - by peak with adj size 13 68910877 111154910 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 13 71230858 114033958 5 - by peak with adj size 13 65103704 106807694 5 - by peak with adj size 2293688 rat Bss29 Bone structure and strength QTL 29 15 5.31 1.0E-4 40084 D15Rat117 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure osteoporosis 2293455 18158281 15 21071031 66071031 5 - by peak with adj size 15 16042557 61042557 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 17249641 62249641 5 - by peak with adj size 15 11111142 56111142 5 - by peak with adj size 2293689 rat Bss47 Bone structure and strength QTL 47 1 7.25 1.0E-4 36460 D1Rat69 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293690 rat Bss45 Bone structure and strength QTL 45 16 5.13 1.0E-4 40234 D16Rat60 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) abnormal bone strength osteoporosis 2293455 18158281 16 41174014 86174014 5 - by peak with adj size 16 41581459 86581459 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 16 41512710 86512710 5 - by peak with adj size 16 37752156 82752156 5 - by peak with adj size 2293691 rat Bmd37 Bone mineral density QTL 37 15 6.6 1.0E-4 40084 D15Rat117 40882 D15Rat97 40882 D15Rat97 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) increased bone mineral density osteoporosis 2293456 18282130 15 43570947 82573380 1 - by flanking markers 15 38542355 78048493 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 39749557 79033707 1 - by flanking markers 15 33611058 71477291 1 - by flanking markers 2293693 rat Bss22 Bone structure and strength QTL 22 1 33.52 1.0E-4 36460 D1Rat69 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293694 rat Bss38 Bone structure and strength QTL 38 1 7.05 1.0E-4 37902 D1Rat169 femur strength trait (VT:0010010) femur stiffness (CMO:0001674) abnormal bone structure osteoporosis 2293455 18158281 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2293696 rat Bmd32 Bone mineral density QTL 32 7 5.1 1.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 femur strength trait (VT:0010010) femoral neck polar moment of inertia (CMO:0001670) increased bone mineral density osteoporosis 2293456 18282130 7 78253693 123378833 1 - by flanking markers 7 74658964 120536775 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293697 rat Bmd39 Bone mineral density QTL 39 8 38742 D8Rat111 35018 D8Rat15 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) increased bone mineral density osteoporosis 2293456 18282130 8 56813094 105836747 1 - by flanking markers 8 57109012 103548876 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 8 58230766 106394378 1 - by flanking markers 8 54043744 98968765 1 - by flanking markers 2293698 rat Bss43 Bone structure and strength QTL 43 10 5.33 1.0E-4 37900 D10Rat124 lumbar vertebra size trait (VT:0010518) lumbar vertebra cross-sectional area (CMO:0001689) abnormal bone strength osteoporosis 2293455 18158281 10 61889555 106889555 5 - by peak with adj size 10 62984501 107984501 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 62096293 107096293 5 - by peak with adj size 10 59209888 104209888 5 - by peak with adj size 2293699 rat Bss49 Bone structure and strength QTL 49 12 5.61 1.0E-4 39060 D12Rat30 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 12 17789999 54450796 5 - by peak with adj size 12 11612769 46782294 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 12 15908900 52716770 5 - by peak with adj size 12 10474137 46669029 5 - by peak with adj size 2293700 rat Bmd27 Bone mineral density QTL 27 1 6.6 1.0E-4 37902 D1Rat169 36874 D1Rat82 37902 D1Rat169 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 1 251652807 272078414 1 - by flanking markers 1 229876870 249951685 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 244401175 264636028 1 - by flanking markers 1 224054293 243747962 1 - by flanking markers 2293701 rat Bmd34 Bone mineral density QTL 34 1 8.3 1.0E-4 37902 D1Rat169 36874 D1Rat82 37902 D1Rat169 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) increased bone mineral density osteoporosis 2293456 18282130 1 251652807 272078414 1 - by flanking markers 1 229876870 249951685 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 244401175 264636028 1 - by flanking markers 1 224054293 243747962 1 - by flanking markers 2293702 rat Bss34 Bone structure and strength QTL 34 13 4.61 1.0E-4 39262 D13Rat86 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 13 75695127 118718031 5 - by peak with adj size 13 68910877 111154910 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 13 71230858 114033958 5 - by peak with adj size 13 65103704 106807694 5 - by peak with adj size 2293703 rat Bss48 Bone structure and strength QTL 48 7 16.05 1.0E-4 37802 D7Rat78 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 7 100878730 143501887 5 - by peak with adj size 7 98036672 143002779 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2293704 rat Bss35 Bone structure and strength QTL 35 18 4.59 2.0E-4 38146 D18Rat50 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 18 29720732 74720732 5 - by peak with adj size 18 31347802 76347802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 30533614 75533614 5 - by peak with adj size 18 28964853 73964853 5 - by peak with adj size 2293705 rat Bmd25 Bone mineral density QTL 25 10 7.1 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293706 rat Bmd20 Bone mineral density QTL 20 6 4.3 2.0E-4 35963 D6Rat46 35653 D6Rat42 35963 D6Rat46 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 6 23080221 31059317 1 - by flanking markers 6 13286615 19901481 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 13122958 21165729 1 - by flanking markers 6 5074497 19988050 1 - by flanking markers 2293707 rat Bss32 Bone structure and strength QTL 32 7 7.64 1.0E-4 35919 D7Rat23 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293708 rat Bss46 Bone structure and strength QTL 46 18 8.8 1.0E-4 37578 D18Rat65 34975 D18Rat13 38146 D18Rat50 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) abnormal bone strength osteoporosis 2293455 18158281 18 15466312 67678102 1 - by flanking markers 18 12245097 66720186 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 15695872 68524999 1 - by flanking markers 18 11791518 63636873 1 - by flanking markers 2293709 rat Bss23 Bone structure and strength QTL 23 6 5.18 1.0E-4 35653 D6Rat42 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 6 8559248 53559248 5 - by peak with adj size 6 1 42401411 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 43665660 5 - by peak with adj size 6 1 42487980 5 - by peak with adj size 2293833 rat Kiddil8 Kidney dilation QTL 8 2 2.9 35849 D2Rat62 36241 D2Rat72 38554 D2Rat112 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) hydronephrosis 2293631 18523158 Kiddil7 (maps to same region) 2 254867191 283538297 1 - by flanking markers 2 228663949 256217383 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 2 236318496 264899009 1 - by flanking markers 2 219753301 247136170 1 - by flanking markers 2293835 rat Kiddil5 Kidney dilation QTL 5 2 3.8 37018 D2Rat14 36213 D2Rat40 41400 D2Rat216 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hematuria;hydronephrosis Hematuria;hydronephrosis 2293631 18523158 2071 Agtr1b 2 61825950 189197988 1 - by flanking markers 2 118154358 163154358 4 - by one flank marker only backcross 631594 1357985 BN/Rj LOU/Ins 2 42776916 169852800 1 - by flanking markers 2 42804607 157142209 1 - by flanking markers 2293837 rat Kiddil1 Kidney dilation QTL 1 6 3.7 33993 D6Mit2 38290 D6Rat76 38268 D6Rat102 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 Kiddil3 (maps to same region) 6 94275468 117085239 1 - by flanking markers 6 84287190 108790535 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 84763275 108464097 1 - by flanking markers 6 81132889 104393926 1 - by flanking markers 2293839 rat Kiddil2 Kidney dilation QTL 2 6 4.8 35134 D6Rat41 33993 D6Mit2 42778 D6Rat171 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 2859;1311209 Id2;Emilin1 Kiddil4 (maps to same region) 6 31931908 94275614 1 - by flanking markers 6 20798926 84287337 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 22042854 84763421 1 - by flanking markers 6 20866422 81133036 1 - by flanking markers 2293840 rat Kiddil9 Kidney dilation QTL 9 4 2.9 35278 D4Rat46 37592 D4Rat141 36898 D4Rat80 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 4 185640598 210231755 1 - by flanking markers 4 122550935 151158853 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 4 120400597 146942261 1 - by flanking markers 4 120926564 148090731 1 - by flanking markers 2293841 rat Kiddil4 Kidney dilation QTL 4 6 4.4 35134 D6Rat41 33993 D6Mit2 42778 D6Rat171 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 2859;1311209 Id2;Emilin1 Kiddil2 (maps to same region) 6 31931908 94275614 1 - by flanking markers 6 20798926 84287337 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 22042854 84763421 1 - by flanking markers 6 20866422 81133036 1 - by flanking markers 2293842 rat Kiddil3 Kidney dilation QTL 3 6 4.3 33993 D6Mit2 38290 D6Rat76 38268 D6Rat102 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 Kiddil1 (maps to same region) 6 94275468 117085239 1 - by flanking markers 6 84287190 108790535 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 84763275 108464097 1 - by flanking markers 6 81132889 104393926 1 - by flanking markers 2293843 rat Kiddil6 Kidney dilation QTL 6 2 3.1 37018 D2Rat14 37672 D2Rat87 41400 D2Rat216 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 2071 Agtr1b 2 61825950 215123776 1 - by flanking markers 2 144377723 189377723 4 - by one flank marker only backcross 631594 1357985 BN/Rj LOU/Ins 2 42776916 195645082 1 - by flanking markers 2 42804607 182042367 1 - by flanking markers 2293844 rat Kiddil7 Kidney dilation QTL 7 2 3.5 35849 D2Rat62 36241 D2Rat72 38554 D2Rat112 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hematuria;hydronephrosis Hematuria;hydronephrosis 2293631 18523158 Kiddil8 (maps to same region) 2 254867191 283538297 1 - by flanking markers 2 228663949 256217383 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 2 236318496 264899009 1 - by flanking markers 2 219753301 247136170 1 - by flanking markers 2298475 rat Eau6 Experimental allergic uveoretinitis QTL 6 7 0.0029 10431 D7Wox18 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation Experimental Autoimmune Uveitis 2296064 18453595 2454;2896;3735;71040;621312;628675 Cyp11b2;Il2rb;Sox10;Txn2;St13;Mapk15 Niddm14 (maps to same region) 7 93629275 138629275 5 - by peak with adj size 7 90478161 135478161 5 - by peak with adj size intercross 61109 1298093 F344/NHsd LEW/NHsd 7 93726906 138726906 5 - by peak with adj size 7 84257275 129257275 5 - by peak with adj size 2298477 rat Eau4 Experimental allergic uveoretinitis QTL 4 3 0.0011 10502 D3Mgh10 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 2031;2200;2327;2810;2954;3267;61965;61998;68326;620228;620811;621320;628786;1303179 Ada;Bcl2l1;Cebpb;Hnf4a;Kcnb1;Pck1;Ptpn1;Ywhab;Vapb;Slco4a1;Slc12a5;Mmp9;Slc13a3;Bpi recessive Iddm13 (maps to same region) 3 152328805 183740530 5 - by peak with adj size 3 139485124 171063335 5 - by peak with adj size intercross 61109 1298093 F344/NHsd LEW/NHsd 3 146232777 177699992 5 - by peak with adj size 3 137398739 169034231 5 - by peak with adj size 2298478 rat Eau8 Experimental allergic uveoretinitis QTL 8 19 0.0163 10418 D19Mit6 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation Experimental Autoimmune Uveitis 2296064 18453595 2406;2444;2503;2825;2835;620573;620981;631410;1304832;1359653;1591020 Bcar1;Ctrb1;Nqo1;Hp;Hsd11b2;Cyba;Calb2;Vac14;Aars1;Kars1;Adat1 Cia14 (maps to same region) 19 32215458 72914587 5 - by peak with adj size 19 19112825 59218465 5 - by peak with adj size intercross 61109 1298093 F344/NHsd LEW/NHsd 19 21407787 62275575 5 - by peak with adj size 19 17154433 57337602 5 - by peak with adj size 2298479 rat Eau5 Experimental allergic uveoretinitis QTL 5 2 0.0021 34461 D2Mgh12 34401 D2Mgh22 67315 D2Arb24 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 2263;2591;3810;69228;69238;70498;70967;620047;620241 Camk2d;Fabp2;Tacr3;Cxxc4;Prss12;Nfkb1;Casp6;Il2;Lef1 additive Cia10 (maps to same region) 2 235592715 272824647 1 - by flanking markers 2 210636008 247306073 1 - by flanking markers intercross 61109 1298093 F344/NHsd LEW/NHsd 2 217498545 254132424 1 - by flanking markers 2 202446871 237938339 1 - by flanking markers 2298480 rat Eau7 Experimental allergic uveoretinitis QTL 7 10 0.0049 34318 D10Mgh10 61279 D10Arb3 33565 D10Mit9 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 2425;2592;2897;2898;2900;2907;2920;3702;621149;628704;628847;1564790 Csf1r;Fabp6;Il3;Il4;Il5;Il9r;Irf1;Slc22a5;Slc22a4;Il12b;Mapk9;Scgb3a2 additive Eae3 (maps to same region);Pia15 (maps to same region) 10 35428387 35954931 1 - by flanking markers 10 35713561 36254741 1 - by flanking markers intercross 61109 1298093 F344/NHsd LEW/NHsd 10 35669573 36185929 1 - by flanking markers 10 27957626 34490668 2 - by one flank and peak markers 2298481 rat Eau9 Experimental allergic uveoretinitis QTL 9 10 0.0169 41939 D10Arb27 34274 D10Mgh5 41298 D10Rat153 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 3185;3644;3645;3647;3830;69069;620441;629472 Nos2;Ccl11;Ccl2;Ccl3;Hnf1b;Ccl5;Ccl4;Cdk5r1 additive Eae18 (maps to same region) 10 67971352 85302564 1 - by flanking markers 10 69160380 86317054 1 - by flanking markers intercross 61109 1298093 F344/NHsd LEW/NHsd 10 68305037 85514044 1 - by flanking markers 10 65927233 82565079 1 - by flanking markers 2298495 rat Eae23 Experimental allergic encephalomyelitis QTL 23 10 16.93 1631253 D10Wox42 41254 D10Rat159 42370 D10Rat238 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis duration (CMO:0001424) CNS inflammation;weight loss Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2293859 16624898 70906;619913;631374;1308200;1309457 Aipl1;Tekt1;Slc13a5;Pitpnm3;Med31 additive Eae18 (sub_region);Eae18a (sub_region);Eae3 (sub_region) 10 56926196 64030303 1 - by flanking markers 10 57438568 63167167 1 - by flanking markers intercross 2298494 Kini:DA,PVG-G10 10 57180653 63976874 1 - by flanking markers 10 55273696 60677262 1 - by flanking markers 2298542 rat Neuinf11 Neuroinflammation QTL 11 3 3.9 36657 D3Rat58 35443 D3Rat30 10260 D3Rat52 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 3 15478680 86480754 1 - by flanking markers 3 10829503 75308165 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 3 10119318 79772001 1 - by flanking markers 3 15005422 76927699 1 - by flanking markers 2298544 rat Neuinf9 Neuroinflammation QTL 9 10 4.6 44672 D10Got12 37450 D10Rat133 36496 D10Rat37 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 10 4695640 64823355 1 - by flanking markers 10 5761138 65668639 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 10 5877536 64401490 2 - by one flank and peak markers 10 5801990 62146030 2 - by one flank and peak markers 2298545 rat Neuinf8 Neuroinflammation QTL 8 1 4.6 37960 D1Rat196 35667 D1Rat107 35268 D1Rat34 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 1 59282428 167925457 1 - by flanking markers 1 55083934 154002647 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 1 58354072 161711996 1 - by flanking markers 1 57336763 151090257 1 - by flanking markers 2298546 rat Neuinf4 Neuroinflammation QTL 4 1 5.1 38230 D1Rat234 37658 D1Rat247 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 1 1 30115455 5 - by peak with adj size 1 1 41225199 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 1 1 28468970 5 - by peak with adj size 1 1 28736750 5 - by peak with adj size 2298547 rat Neuinf5 Neuroinflammation QTL 5 7 3.7 37382 D7Rat113 39094 D7Rat58 41516 D7Rat148 nervous system integrity trait (VT:0010566) spinal cord Cd74 protein level (CMO:0002131) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 7 12498167 67382413 1 - by flanking markers 7 10973606 87034412 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 7 12328467 67193263 1 - by flanking markers 7 9462246 58265113 1 - by flanking markers 2298548 rat Neuinf7 Neuroinflammation QTL 7 10 3.4 37450 D10Rat133 35627 D10Rat12 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 10 64823161 112200500 2 - by one flank and peak markers 10 65668446 110718848 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 10 75544754 112626471 5 - by peak with adj size 10 72224939 107211142 5 - by peak with adj size 2298549 rat Neuinf12 Neuroinflammation QTL 12 15 3.5 37794 D15Rat48 38578 D15Rat73 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 15 1 65959514 2 - by one flank and peak markers 15 1 61161186 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 15 1 62301382 2 - by one flank and peak markers 15 1 55302115 2 - by one flank and peak markers 2298550 rat Neuinf6 Neuroinflammation QTL 6 7 3.3 36715 D7Rat30 37382 D7Rat113 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 7 1 34212335 2 - by one flank and peak markers 7 1 30339432 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 7 1 34147172 2 - by one flank and peak markers 7 1 27829089 2 - by one flank and peak markers 2298551 rat Neuinf10 Neuroinflammation QTL 10 11 3.7 35933 D11Rat12 37942 D11Rat46 41240 D11Rat83 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 11 35759925 85534312 1 - by flanking markers 11 31988113 81091531 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 11 32155520 82443118 1 - by flanking markers 11 31239134 78851519 1 - by flanking markers 2299160 rat Iddm35 Insulin dependent diabetes mellitus QTL 35 18 2.79 39582 D18Rat109 42052 D18Arb6 40002 D18Rat116 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 18 4393832 61757227 1 - by flanking markers 18 4320091 76880933 2 - by one flank and peak markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 18 4407513 62570466 1 - by flanking markers 18 4207941 60377792 1 - by flanking markers 2299161 rat Iddm33 Insulin dependent diabetes mellitus QTL 33 2 2.98 35599 D2Rat82 34858 D2Rat69 36876 D2Rat88 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 1307992 Ptpn22 2 239538172 272813962 1 - by flanking markers 2 214633709 247295816 1 - by flanking markers 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 2 221488355 254121739 1 - by flanking markers 2 206312063 220876787 2 - by one flank and peak markers 2299162 rat Iddm32 Insulin dependent diabetes mellitus QTL 32 2 2.36 36693 D2Rat75 34005 D2Mit8 39090 D2Rat180 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 620047;1307384;1359309 Il2;Il21;Adad1 2 100298393 169047413 1 - by flanking markers 2 79796790 148790758 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 2 80631950 149614623 1 - by flanking markers 2 78665616 143657569 1 - by flanking markers 2299163 rat Iddm34 Insulin dependent diabetes mellitus QTL 34 7 2.71 36015 D7Rat21 35034 D7Rat2 1633865 D7Wox48 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 7 100609080 143501887 2 - by one flank and peak markers 7 96517746 137757704 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 7 100028953 145729302 2 - by one flank and peak markers 7 91281130 135012528 2 - by one flank and peak markers 2300002 rat Iddm36 Insulin dependent diabetes mellitus QTL 36 17 1.98 35354 D17Rat6 37402 D17Rat78 36185 D17Rat11 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2299158;2303106 19168599 17 12655344 44408022 1 - by flanking markers 17 16053169 47628829 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 17 10529709 42542027 1 - by flanking markers 17 9991286 40540197 1 - by flanking markers 2300157 rat Bmd66 Bone mineral density QTL 66 18 13.1 1.0E-4 38146 D18Rat50 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 18 29720732 74720732 5 - by peak with adj size 18 31347802 76347802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 30533614 75533614 5 - by peak with adj size 18 28964853 73964853 5 - by peak with adj size 2300159 rat Bmd61 Bone mineral density QTL 61 14 5.3 1.0E-4 39204 D14Rat54 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 14 1 27589631 5 - by peak with adj size 14 1 27616586 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 14 1 27597761 5 - by peak with adj size 14 1 26541967 5 - by peak with adj size 2300161 rat Bmd43 Bone mineral density QTL 43 1 8.4 1.0E-4 36460 D1Rat69 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2300163 rat Bmd64 Bone mineral density QTL 64 16 5.3 1.0E-4 40234 D16Rat60 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 16 41174014 86174014 5 - by peak with adj size 16 41581459 86581459 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 16 41512710 86512710 5 - by peak with adj size 16 37752156 82752156 5 - by peak with adj size 2300164 rat Bmd44 Bone mineral density QTL 44 1 5.4 1.0E-4 39532 D1Rat261 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd45 (interacts with) 1 59474685 104474685 5 - by peak with adj size 1 56601368 101601368 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 58209327 103209327 5 - by peak with adj size 1 56949932 101949932 5 - by peak with adj size 2300165 rat Bmd49 Bone mineral density QTL 49 2 4.8 1.0E-4 40462 D2Rat280 lumbar vertebra mineral mass (VT:0010511) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 2 111366095 156366095 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 2300167 rat Bmd63 Bone mineral density QTL 63 15 5.9 1.0E-4 40084 D15Rat117 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 15 21071031 66071031 5 - by peak with adj size 15 16042557 61042557 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 17249641 62249641 5 - by peak with adj size 15 11111142 56111142 5 - by peak with adj size 2300168 rat Bmd47 Bone mineral density QTL 47 2 6.6 1.0E-4 39874 D2Rat198 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 2 39687057 84687057 5 - by peak with adj size 2 20374107 65374107 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 20641371 65641371 5 - by peak with adj size 2 20662448 65662448 5 - by peak with adj size 2300170 rat Bmd45 Bone mineral density QTL 45 2 12.1 1.0E-4 40462 D2Rat280 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd41 (interacts with);Bmd44 (interacts with);Bmd59 (interacts with) 2 111366095 156366095 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 2300171 rat Bmd58 Bone mineral density QTL 58 10 4.9 1.0E-4 40302 D10Rat162 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 10 28547602 73547602 5 - by peak with adj size 10 28599269 73599269 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 28789280 73789280 5 - by peak with adj size 10 26944628 71944628 5 - by peak with adj size 2300172 rat Bmd57 Bone mineral density QTL 57 10 9.8 1.0E-4 36283 D10Rat15 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 10 72743019 112200500 5 - by peak with adj size 10 74167134 110718848 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 73008136 112626471 5 - by peak with adj size 10 69738412 107211142 5 - by peak with adj size 2300173 rat Bmd62 Bone mineral density QTL 62 15 12.8 1.0E-4 40084 D15Rat117 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105;2316850 18707222;19153792;19841953 1308288;1311147;1312015;1359146;1592114 Lcp1;Mdp1;Xpo4;Pdhb;Esd Bmd67 (interacts with) 15 21071031 66071031 5 - by peak with adj size 15 16042557 61042557 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 17249641 62249641 5 - by peak with adj size 15 11111142 56111142 5 - by peak with adj size 2300174 rat Bmd42 Bone mineral density QTL 42 1 8.4 1.0E-4 36460 D1Rat69 lumbar vertebra mineral mass (VT:0010511) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2300175 rat Bmd40 Bone mineral density QTL 40 1 15.4 1.0E-4 37902 D1Rat169 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2300176 rat Bmd51 Bone mineral density QTL 51 6 11.7 1.0E-4 35963 D6Rat46 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 2300177 rat Bmd65 Bone mineral density QTL 65 18 19.7 1.0E-4 38146 D18Rat50 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 18 29720732 74720732 5 - by peak with adj size 18 31347802 76347802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 30533614 75533614 5 - by peak with adj size 18 28964853 73964853 5 - by peak with adj size 2300178 rat Bmd54 Bone mineral density QTL 54 7 5.3 1.0E-4 35919 D7Rat23 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2300179 rat Bmd50 Bone mineral density QTL 50 4 5.9 1.0E-4 38262 D4Rat103 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd60 (interacts with) 4 126636060 171636060 5 - by peak with adj size 4 60200806 105200806 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 4 61975371 106975371 5 - by peak with adj size 4 60928534 105928534 5 - by peak with adj size 2300180 rat Bmd67 Bone mineral density QTL 67 18 4.8 1.0E-4 37578 D18Rat65 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd62 (interacts with) 18 1 37966407 5 - by peak with adj size 18 1 34745192 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 1 38195967 5 - by peak with adj size 18 1 34291613 5 - by peak with adj size 2300181 rat Bmd55 Bone mineral density QTL 55 8 5.7 1.0E-4 35018 D8Rat15 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 8 83336673 128336673 5 - by peak with adj size 8 81048802 126048802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 8 83894304 128894304 5 - by peak with adj size 8 76468691 121468691 5 - by peak with adj size 2300182 rat Bmd56 Bone mineral density QTL 56 8 5.4 36327 D8Rat2 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd53 (interacts with) 8 103904881 132457389 5 - by peak with adj size 8 100915338 129041809 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 8 104682575 133307652 5 - by peak with adj size 8 95718998 123900184 5 - by peak with adj size 2300183 rat Bmd60 Bone mineral density QTL 60 14 5.7 1.0E-4 39204 D14Rat54 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd50 (interacts with);Bmd68 (interacts with) 14 1 27589631 5 - by peak with adj size 14 1 27616586 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 14 1 27597761 5 - by peak with adj size 14 1 26541967 5 - by peak with adj size 2300184 rat Bmd53 Bone mineral density QTL 53 7 5.4 1.0E-4 37802 D7Rat78 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd56 (interacts with) 7 100878730 143501887 5 - by peak with adj size 7 98036672 143002779 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2300185 rat Bmd46 Bone mineral density QTL 46 2 8.4 1.0E-4 40462 D2Rat280 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 2 111366095 156366095 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 2300186 rat Bmd59 Bone mineral density QTL 59 12 7.1 1.0E-4 39060 D12Rat30 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd45 (interacts with) 12 17789999 54450796 5 - by peak with adj size 12 11612769 46782294 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 12 15908900 52716770 5 - by peak with adj size 12 10474137 46669029 5 - by peak with adj size 2300187 rat Bmd41 Bone mineral density QTL 41 1 8.9 1.0E-4 36460 D1Rat69 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd45 (interacts with) 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2300188 rat Bmd68 Bone mineral density QTL 68 20 6.4 1.0E-4 37792 D20Rat29 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd60 (interacts with) 20 28247365 57791882 5 - by peak with adj size 20 25555772 55268282 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 20 26608843 56205956 5 - by peak with adj size 20 25106722 54435887 5 - by peak with adj size 2300189 rat Bmd48 Bone mineral density QTL 48 2 5.8 1.0E-4 36031 D2Rat54 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 2 212470173 257470173 5 - by peak with adj size 2 187512114 232512114 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 194378622 239378622 5 - by peak with adj size 2 179335906 224335906 5 - by peak with adj size 2300190 rat Bmd52 Bone mineral density QTL 52 6 11.2 1.0E-4 35963 D6Rat46 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 2300197 rat Scl59 Serum cholesterol level QTL 59 14 38070 D14Rat43 43032 D14Rat132 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 2300117 18753676 1309450 Ppp4r3b Scl45 (sub_region) 14 78419915 110102984 1 - by flanking markers 14 79256324 107101727 1 - by flanking markers 2300195 EHC.BN-(D14Rat43-D14Rat132)/Kyu 14 78446303 110402569 1 - by flanking markers 14 55147478 100147478 4 - by one flank marker only 2300218 rat Hpcl2 Hepatic cholesterol level QTL 2 10 34100 D10Mgh3 69423 Srebf1 liver cholesterol amount (VT:0010498) liver cholesterol level (CMO:0001597) increased cholesterol level steatotic liver disease 1643359 18071061 69423 Srebf1 10 46348035 98640137 1 - by flanking markers 10 46483646 100090301 1 - by flanking markers intercross 2300217 SHR.BN-(D10Mgh3-Srebf1)/Ipcv 10 46593021 98939209 1 - by flanking markers 10 45029650 95600334 1 - by flanking markers 2300324 rat Fetw1 Fetal weight QTL 1 1 12.1 0.005 40.0 39312 D1Rat212 35569 D1Rat30 41498 D1Rat266 fetal growth trait (VT:0004201) fetal body weight (CMO:0002080) abnormal fetal growth/weight/body size Metabolic Syndrome 2300320 16914718 1 89791366 107050002 1 - by flanking markers 1 55540384 100540384 4 - by one flank marker only 61098 61099 BXH/Ipcv HXB/Ipcv 1 88634585 106002500 1 - by flanking markers 1 85424647 100358001 1 - by flanking markers 2300326 rat Plaw1 Placental weight QTL 1 15 15.0 0.005 43.0 36663 D15Rat21 41308 D15Rat107 40252 D15Rat101 placenta mass (VT:0004257) placenta wet weight (CMO:0002088) decreased placenta weight Metabolic Syndrome 2300320 16914718 15 79317523 112781949 1 - by flanking markers 15 74779702 109758846 4 - by one flank marker only 61098 61099 BXH/Ipcv HXB/Ipcv 15 75761024 109400896 1 - by flanking markers 15 68327165 100062518 1 - by flanking markers 2301398 rat Kidm38 Kidney mass QTL 38 10 0.002 1578983 D10Chm156 2875 Igfbp4 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 10 86759484 98999296 1 - by flanking markers 10 87834315 100429624 1 - by flanking markers 728384 SS.LEW-(D10Rat24-Igfbp4)/Ayd 10 86962563 99303173 1 - by flanking markers 10 84007272 95933025 1 - by flanking markers 2301400 rat Cm68 Cardiac mass QTL 68 3 0.001 728036 D3Chm60 39584 D3Rat206 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 3 36274422 79557281 1 - by flanking markers 3 27762470 68832545 1 - by flanking markers 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd 3 31103589 72989078 1 - by flanking markers 3 31426403 70668733 1 - by flanking markers 2301402 rat Bp316 Blood pressure QTL 316 8 0.005 35018 D8Rat15 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1302764;1599557 15257171;17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 61394378 106394378 4 - by one flank marker only 8 53968765 98968765 4 - by one flank marker only 2301404 rat Bp321 Blood pressure QTL 321 16 0.05 1358042 D16Chm66 39456 D16Rat88 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1599557 17143582 16 1534551 3405986 1 - by flanking markers 16 819369 3080748 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 3439525 1 - by flanking markers 16 832380 2995225 1 - by flanking markers 2301405 rat Cm69 Cardiac mass QTL 69 10 0.031 1578987 D10Chm229 1578931 D10Chm171 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight 1599557;1559293 17143582;16286573 10 68361762 69797898 1 - by flanking markers 10 69555329 71032765 1 - by flanking markers 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd 10 68697928 70167191 1 - by flanking markers 10 66319447 67750281 1 - by flanking markers 2301406 rat Kidm39 Kidney mass QTL 39 16 0.002 38834 D16Rat35 1358034 D16Chm63 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 16 3263508 17347173 1 - by flanking markers 16 2935812 16359278 1 - by flanking markers 1358161 SS.LEW-(D16Rat38-D16Chm66)/Ayd 16 3296688 17464293 1 - by flanking markers 16 2851709 15884239 1 - by flanking markers 2301408 rat Kidm36 Kidney mass QTL 36 2 0.002 10153 D2Wox37 2044 Adh1c kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 2 225014411 262102977 1 - by flanking markers 2 198324984 235811584 1 - by flanking markers 1358167 SS.MNS-(D2Wox27-Adh1)/Ayd 2 205583921 243562243 1 - by flanking markers 2 190613715 226808892 1 - by flanking markers 2301409 rat Cm70 Cardiac mass QTL 70 18 0.001 38430 D18Rat62 1578949 D18Chm91 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) abnormal heart weight 1599557 17143582 18 7012157 15053556 1 - by flanking markers 18 6934443 12677409 1 - by flanking markers 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd 18 7057769 15274626 1 - by flanking markers 18 6791251 12205285 1 - by flanking markers 2301410 rat Bp317 Blood pressure QTL 317 18 0.004 11462 D18Wox7 40842 D18Rat101 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1578386;1599557 16278234;17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 2301411 rat Bp320 Blood pressure QTL 320 3 0.001 35378 D3Rat61 43758 D3Wox1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 2301412 rat Kidm40 Kidney mass QTL 40 17 0.001 12904060 D17Chm70 39318 D17Rat65 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 17 43435496 88435496 4 - by one flank marker only 17 72287524 93930006 1 - by flanking markers 1559032 1559037 SS.LEW-(D17Rat65-D17Chm2)/Ayd SS.LEW-(D17Chm9-D17Rat97)/Ayd 17 41731080 86731080 4 - by one flank marker only 17 37479847 82479847 4 - by one flank marker only 2301413 rat Bp318 Blood pressure QTL 318 18 0.002 40842 D18Rat101 1579069 D18Chm56 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1578386;1599557;7421500 16278234;17143582;23814039 Bp347 (interacts with) 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 2301414 rat Kidm37 Kidney mass QTL 37 3 0.001 39584 D3Rat206 36717 D3Rat17 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557;724791 17143582;14517349 3 79476405 133513825 1 - by flanking markers 3 68816911 121619110 1 - by flanking markers 1357981 SS.LEW-(D3Mco21-D3Rat17)/Ayd 3 72973445 127023997 1 - by flanking markers 3 70653097 121056321 1 - by flanking markers 2301415 rat Cm67 Cardiac mass QTL 67 2 0.003 66535 D2Mco8 3195 Npr1 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal aortic weight;abnormal heart weight;decreased kidney weight hypertension 1599557 17143582 2 192132537 209287892 1 - by flanking markers 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd 2 172795683 189857032 1 - by flanking markers 2 152413072 175950118 1 - by flanking markers 2301416 rat Bp315 Blood pressure QTL 315 8 0.008 39028 D8Rat70 34723 D8Mgh9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1302764;1599557;7421500 15257171;17143582;23814039 Bp279 (interacts with);Bp310 (interacts with) 8 8714659 53714659 4 - by one flank marker only 8 7408118 52408118 4 - by one flank marker only 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd 8 8738677 53738677 4 - by one flank marker only 8 7670578 52670578 4 - by one flank marker only 2301417 rat Bp319 Blood pressure QTL 319 18 0.002 37568 D18Rat55 62466 D18Uia6 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1578386;1599557;8657072 16278234;17143582;21602714 1564431 Alpk2 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 2301962 rat Cm72 Cardiac mass QTL 72 13 4.12 10462 D13Mgh13 34567 D13Kid1 11232 D13Arb7 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) heart left ventricle hypertrophy hypertension 2301936 18925692 13 41256240 69865404 2 - by one flank and peak markers 13 23769973 68769973 5 - by peak with adj size intercross 10016 631602 GH/Omr BN/Elh 13 36147533 64868393 2 - by one flank and peak markers 13 31241331 58363171 2 - by one flank and peak markers 2301964 rat Bp323 Blood pressure QTL 323 6 4.3 33993 D6Mit2 11241 D6Mit3 33828 D6Mit9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 additive Bp322 (interacts with);Bp324 (interacts with) 6 85163291 94275468 1 - by flanking markers 6 75049644 84287190 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 6 75623393 84763275 1 - by flanking markers 6 72227641 81132889 1 - by flanking markers 2301966 rat Bp322 Blood pressure QTL 322 2 3.58 34204 D2Mgh7 34461 D2Mgh12 34292 D2Mgh8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 additive Bp323 (interacts with);Bp324 (interacts with) 2 177516922 235592880 1 - by flanking markers 2 156142685 210636169 1 - by flanking markers F2 intercross 10016 631602 GH/Omr BN/Elh 2 158159186 217498710 1 - by flanking markers 2 150540301 202447032 1 - by flanking markers 2301967 rat Cm73 Cardiac mass QTL 73 10 4.55 33585 D10Mit6 33690 D10Mit7 34669 D10Mgh20 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy hypertension 2301936 18925692 10 14644150 92109374 2 - by one flank and peak markers 10 14721135 92841289 2 - by one flank and peak markers intercross 10016 631602 GH/Omr BN/Elh 10 14827894 92423564 2 - by one flank and peak markers 10 14487011 89062041 2 - by one flank and peak markers 2301969 rat Bp324 Blood pressure QTL 324 18 4.05 34290 D18Mgh4 34218 D18Mgh2 34270 D18Mgh6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 Bp322 (interacts with);Bp323 (interacts with) 18 61092546 79012526 1 - by flanking markers 18 62313296 79585008 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 18 61901354 79948616 1 - by flanking markers 18 59712417 76477814 1 - by flanking markers 2301970 rat Bw81 Body weight QTL 81 3 5.19 10678 D3Mgh21 34316 D3Mgh2 33808 D3Mit4 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 2301936 18925692 3 48366676 169801169 1 - by flanking markers 3 39052756 158038027 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 3 43295930 163640485 1 - by flanking markers 3 41874578 155617519 1 - by flanking markers 2301971 rat Cm71 Cardiac mass QTL 71 3 4.63 10678 D3Mgh21 34316 D3Mgh2 33808 D3Mit4 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) heart left ventricle hypertrophy hypertension 2301936 18925692 3 48366676 169801169 1 - by flanking markers 3 39052756 158038027 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 3 43295930 163640485 1 - by flanking markers 3 41874578 155617519 1 - by flanking markers 2301972 rat Bp325 Blood pressure QTL 325 6 4.8 34643 D6Pas1 11241 D6Mit3 33828 D6Mit9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 6 7513619 85163291 1 - by flanking markers 6 7680593 75049644 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 6 1 75623393 2 - by one flank and peak markers 6 1 72227641 2 - by one flank and peak markers 2302038 rat Pia31 Pristane induced arthritis QTL 31 1 5.5 0.001 36550 D1Rat12 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Pia8 (maps to same region) 1 15026219 60026219 5 - by peak with adj size 17 1 26143121 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 1 13629251 58629251 5 - by peak with adj size 1 10992065 55992065 5 - by peak with adj size 2302040 rat Pia35 Pristane induced arthritis QTL 35 1 3.8 0.001 10445 D1Wox25 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Eae7 (maps to same region) 1 243714234 288714234 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 1 236265430 281265430 5 - by peak with adj size 1 216255568 260522016 5 - by peak with adj size 2302042 rat Pia38 Pristane induced arthritis QTL 38 12 3.5 0.001 11449 D12Wox14 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 Cia12 (maps to same region);Pia4 (maps to same region) 12 4514063 49514063 5 - by peak with adj size 12 568621 45568621 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 12 2513442 47513442 5 - by peak with adj size 12 1 44503507 5 - by peak with adj size 2302043 rat Pia27 Pristane induced arthritis QTL 27 11 18.6 0.001 10376 D11Wox6 11044 D11Wox5 11044 D11Wox5 blood immunoglobulin amount (VT:0002460) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 dominant 11 89808347 90495881 1 - by flanking markers 11 84560085 85432136 1 - by flanking markers intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 11 86714475 87444587 1 - by flanking markers 11 82566545 83440803 1 - by flanking markers 2302045 rat Pia39 Pristane induced arthritis QTL 39 14 4.9 0.001 38932 D14Rat36 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G2a level (CMO:0002116) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 recessive Pia6 (maps to same region) 14 10333529 55333529 5 - by peak with adj size 14 10539919 55539919 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 14 10539977 55539977 5 - by peak with adj size 14 8267090 53267090 5 - by peak with adj size 2302047 rat Pia34 Pristane induced arthritis QTL 34 19 5.8 0.001 33581 D19Mit1 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Eae8 (maps to same region) intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 2302049 rat Pia32 Pristane induced arthritis QTL 32 4 5.1 0.001 33933 D4Mit16 blood autoantibody amount (VT:0003725) serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 recessive Pia7 (interacts with) 4 169786277 214786277 5 - by peak with adj size 4 107728559 152728559 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 4 105277348 150277348 5 - by peak with adj size 4 105789505 150789505 5 - by peak with adj size 2302051 rat Pia28 Pristane induced arthritis QTL 28 4 5.3 0.001 35325 D4Rat41 blood autoantibody amount (VT:0003725) serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive 4 140044845 185044845 5 - by peak with adj size 4 74123346 119123346 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 4 75258970 120258970 5 - by peak with adj size 4 73630210 118630210 5 - by peak with adj size 2302053 rat Pia33 Pristane induced arthritis QTL 33 5 5.0 0.001 11072 D5Mgh2 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G level (CMO:0002102) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 dominant 16 39315759 84315759 3 - by peak only 5 1 40017184 3 - by peak only intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 2302055 rat Pia30 Pristane induced arthritis QTL 30 3 3.5 0.001 11263 D3Wox14 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 3 35956364 80956364 5 - by peak with adj size 3 25222506 70222506 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 3 29321714 74321714 5 - by peak with adj size 3 27936919 72936919 5 - by peak with adj size 2302057 rat Pia29 Pristane induced arthritis QTL 29 16 3.6 0.001 34007 D16Mit3 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 recessive 16 24569673 69569673 5 - by peak with adj size 16 24934312 69934312 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 16 24846541 69846541 5 - by peak with adj size 16 21735975 66735975 5 - by peak with adj size 2302059 rat Pia36 Pristane induced arthritis QTL 36 1 3.8 0.001 11144 D1Wox11 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 Cia2 (maps to same region) 1 40899304 85899304 5 - by peak with adj size 1 41645883 86645883 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 1 41907249 86907249 5 - by peak with adj size 1 43333002 88333002 5 - by peak with adj size 2302060 rat Pia37 Pristane induced arthritis QTL 37 12 6.1 0.001 34070 D12Mgh7 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Apr1 (maps to same region) 12 20591035 54450796 5 - by peak with adj size 12 14334630 46782294 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 12 18729043 52716770 5 - by peak with adj size 12 13198157 46669029 5 - by peak with adj size 2302273 rat Gluco35 Glucose level QTL 35 3 5.3 0.001 42126 D3Arb18 33901 D3Mit12 33901 D3Mit12 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 Gluco39 (maps to same region) 3 90520542 126035097 1 - by flanking markers 3 79283621 114574752 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 3 83817637 119509260 1 - by flanking markers 3 80800231 114297550 1 - by flanking markers 2302275 rat Gluco37 Glucose level QTL 37 13 3.8 36922 D13Rat4 11375 D13Arb8 41978 D13Arb5 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 13 19680631 56629737 1 - by flanking markers 13 1265159 47698301 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 13 14441582 51577031 1 - by flanking markers 13 11929449 46193066 1 - by flanking markers 2302276 rat Bw82 Body weight QTL 82 3 4.32 34336 D3Mgh7 42139 D3Arb8 11261 D3Wox9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 2298688 18612083 Bw117 (maps to same region);Bw24 (maps to same region);Bw31 (maps to same region);Bw36 (maps to same region) 3 45609749 71439037 1 - by flanking markers 3 36556706 60697201 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 3 40523593 64880586 1 - by flanking markers 3 39454637 62951183 1 - by flanking markers 2302277 rat Gluco38 Glucose level QTL 38 14 5.8 33953 D14Mit1 34890 D14Rat9 67231 D14Arb18 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 Bw5 (maps to same region);Pia6 (maps to same region) 14 12623297 29969376 1 - by flanking markers 14 12386493 30087990 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 14 12680424 30155192 1 - by flanking markers 14 11030622 28035204 1 - by flanking markers 2302278 rat Gluco36 Glucose level QTL 36 8 4.2 40746 D8Rat162 33973 D8Mit2 36117 D8Rat46 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 Niddm21 (maps to same region) 8 32227585 52686094 1 - by flanking markers 8 30878636 53049477 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 8 32201981 54065241 1 - by flanking markers 8 29502665 50095447 1 - by flanking markers 2302365 rat Gluco40 Glucose level QTL 40 17 4.79 16.7 45514 D17Wox8 45485 D17Wox9 33707 D17Mit5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome 619689 10720472 17 63969577 87905751 1 - by flanking markers 17 65900518 93489534 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 17 62195822 86194199 1 - by flanking markers 17 57246843 82046127 1 - by flanking markers 2302367 rat Slep5 Serum leptin concentration QTL 5 8 3.43 33858 D8Mit4 33628 D8Mit6 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 619689 10720472 8 11331573 44187546 1 - by flanking markers 8 9581375 44484215 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 8 11373509 45712344 1 - by flanking markers 8 9712463 41866876 1 - by flanking markers 2302369 rat Scl60 Serum cholesterol level QTL 60 5 3.13 34210 D5Mgh14 34206 D5Mgh15 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Metabolic Syndrome 619689 10720472 5 153255850 171364652 1 - by flanking markers 5 150236110 167844737 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 5 149568588 167739697 1 - by flanking markers 5 143608201 161165651 1 - by flanking markers 2302371 rat Stl22 Serum triglyceride level QTL 22 4 5.15 18.2 10800 D4Wox27 33757 D4Mit2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome 619689 10720472 4 3096322 55539285 1 - by flanking markers 4 460493 55370202 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 4 3044017 55791834 1 - by flanking markers 4 5218294 57114705 1 - by flanking markers 2302373 rat Gluco39 Glucose level QTL 39 3 5.01 24.2 34240 D3Mgh1 34228 D3Mgh5 33927 D3Mit3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome 619689;2298688 10720472;18612083 recessive Gluco35 (maps to same region) 3 109733980 176999783 1 - by flanking markers 3 97524000 163778606 1 - by flanking markers 737957 1357345 WOKW/K DA/K 3 103141944 170934860 1 - by flanking markers 3 98535386 161695835 1 - by flanking markers 2302375 rat Bw83 Body weight QTL 83 1 4.87 2.0E-4 30.7 33753 D1Mit5 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) increased body mass index;increased body weight Metabolic Syndrome;obesity 619689 10720472 Bw18 (maps to same region);Niddm1 (maps to same region);Niddm7 (maps to same region) 1 222606650 270717037 1 - by flanking markers 1 202790380 247322277 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 1 215711860 260711860 4 - by one flank marker only 1 197697768 242697768 4 - by one flank marker only 2302377 rat Scl61 Serum cholesterol level QTL 61 17 4.36 12.5 33790 D17Mit3 45450 D17Wox3 33882 D17Mit2 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating cholesterol level Metabolic Syndrome 619689 10720472 17 29981162 54244197 1 - by flanking markers 17 33639527 62009961 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 17 28073589 56207236 1 - by flanking markers 17 27389946 53481766 1 - by flanking markers 2302378 rat Insul11 Insulin level QTL 11 1 3.25 33959 D1Mit3 10674 D1Mgh12 33753 D1Mit5 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level Metabolic Syndrome 619689 10720472 dominant 1 162692213 270717037 1 - by flanking markers 1 146971846 247322277 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 1 156446196 274977688 2 - by one flank and peak markers 1 144267353 251128347 2 - by one flank and peak markers 2302380 rat Slep6 Serum leptin concentration QTL 6 16 3.36 10660 D16Mgh3 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 619689 10720472 16 1 31479065 5 - by peak with adj size 16 1 32464321 5 - by peak with adj size intercross 737957 1357345 WOKW/K DA/K 16 1 33160624 5 - by peak with adj size 16 1 32139025 5 - by peak with adj size 2302381 rat Bw84 Body weight QTL 84 5 4.47 15.9 34216 D5Mgh6 34041 D5Mit5 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body mass index;increased body weight Metabolic Syndrome;obesity 619689 10720472 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 2303028 rat Bp329 Blood pressure QTL 329 13 42997 D13Rat179 45069 D13Got53 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678;10755344 17566075;22912817 3654;67366;619761;620349 Sele;Pla2g4a;Fmo3;Ptgs2 Bp328 (interacts with);Bp387 (maps to same region) 13 68591963 83929327 1 - by flanking markers 13 60669450 76779489 1 - by flanking markers intercross 2302984 SS.BN-(D13Rat151-D13Rat197)/Mcwi 13 63611283 79034003 1 - by flanking markers 13 58497872 73485113 1 - by flanking markers 2303030 rat Bp327 Blood pressure QTL 327 13 39804 D13Rat111 39208 D13Rat88 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 2446;620465 Ctse;Cxcr4 Bp326 (interacts with);Bp328 (interacts with) 13 40421740 51509512 1 - by flanking markers 13 32030139 42627837 1 - by flanking markers intercross 2302985 SS.BN-(D13Rat111-D13Got22)/Mcwi 13 35301263 46444796 1 - by flanking markers 13 30395351 41184251 1 - by flanking markers 2303031 rat Bp326 Blood pressure QTL 326 13 35975 D13Rat7 39032 D13Rat60 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 Bp327 (interacts with);Bp328 (interacts with) 13 19518130 32069874 1 - by flanking markers 13 1084268 13053933 1 - by flanking markers intercross 2302987 SS.BN-(D13Rat7-D13Rat60)/Mcwi 13 14279081 26919398 1 - by flanking markers 13 11766535 23001904 1 - by flanking markers 2303032 rat Bp328 Blood pressure QTL 328 13 39208 D13Rat88 38240 D13Rat91 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 2048;3554;621137;1303151 Adora1;Ren;Rnpep;Adipor1 Bp326 (interacts with);Bp327 (interacts with);Bp329 (interacts with) 13 51509286 55853202 1 - by flanking markers 13 42627610 46912163 1 - by flanking markers intercross 2293145 SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi 13 46444570 50799665 1 - by flanking markers 13 41184022 45417941 1 - by flanking markers 2303118 rat Mamtr7 Mammary tumor resistance QTL 7 10 0.003 37526 D10Rat91 41584 D10Rat135 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) decreased incidence of tumors by chemical induction;increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 2302423 19052818 10 8619955 108145987 1 - by flanking markers 10 9762188 108776963 1 - by flanking markers intercross 2303116 SPRD.WKY-(D10Rat91-D10Rat135)/Ibmm 10 9841807 108540162 1 - by flanking markers 10 9658275 104670812 1 - by flanking markers 2303120 rat Mamtr8 Mammary tumor resistance QTL 8 18 0.001 10689 D18Mit5 39278 D18Rat44 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) decreased incidence of tumors by chemical induction;increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 2302423 19052818 18 32348154 86114102 1 - by flanking markers 18 32458819 86863412 1 - by flanking markers intercross 1599760 SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm 18 32670352 87080053 1 - by flanking markers 18 31359408 83218561 1 - by flanking markers 2303168 rat Bp330 Blood pressure QTL 330 4 4.25 0.017 2901 Il6 34367 D4Mgh8 11015 D4Mit24 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2303163 8829824 3197 Npy 4 3095536 208551950 1 - by flanking markers 4 456799 149181446 1 - by flanking markers intercross 61119 1302620 WKY/NCrlCrlj SHR/Kyo 4 3043231 145254791 1 - by flanking markers 4 5214602 146446691 1 - by flanking markers 2303170 rat Bp332 Blood pressure QTL 332 9 3.73 0.027 11312 D9Bro1 33842 D9Mit6 10404 D9Mit2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial systolic blood pressure hypertension 2303163;2302803 8829824;18854752 2421 Crygc Bp333 (maps to same region) 9 59092893 82501727 2 - by one flank and peak markers 9 1526958 74813097 1 - by flanking markers intercross 61119 1302620 WKY/NCrlCrlj SHR/Kyo 9 60810298 82732466 2 - by one flank and peak markers 9 55847841 77026453 2 - by one flank and peak markers 2303171 rat Bp331 Blood pressure QTL 331 8 5.57 0.005 34415 D8Mgh6 10054 D8Wox10 10054 D8Wox10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2303163 8829824 3346 Plcd1 8 65466908 127239811 1 - by flanking markers 8 64762472 124310219 1 - by flanking markers intercross 61119 1302620 WKY/NCrlCrlj SHR/Kyo 8 65717449 128033050 1 - by flanking markers 8 61290298 119084929 1 - by flanking markers 2303178 rat Bp334 Blood pressure QTL 334 9 3.7 0.01 61287 D9Uia6 2302873 D9Mco93 44654 D9Got111 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) decreased mean systemic arterial blood pressure 2302803;6903249 18854752;21814219 Bp108 (interacts with);Bp34 (interacts with);Pur31 (sub_region) 9 83451810 97845437 1 - by flanking markers 9 77170797 90249887 1 - by flanking markers intercross 2303153 SS.SHR-(D9Rat7-D9Mco93)/Mco 9 83686153 98164303 1 - by flanking markers 9 79271511 91616855 1 - by flanking markers 2303180 rat Bp333 Blood pressure QTL 333 9 0.001 2302913 D9Mco76 2302927 D9Mco85 44654 D9Got111 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) decreased mean systemic arterial blood pressure;decreased urine protein level 2302803;6903249 18854752;21814219 Bp108 (maps to same region);Bp284 (maps to same region);Bp332 (maps to same region);Bp34 (maps to same region);Bp356 (sub_region);Cm28 (maps to same region) 9 61414200 82659881 1 - by flanking markers 9 53933135 76456066 1 - by flanking markers intercross 2303154 SS.SHR-(D9Wox16-D9Mco85)/Mco 9 61730923 82890620 1 - by flanking markers 9 56627713 78595166 1 - by flanking markers 2303559 rat Gluco54 Glucose level QTL 54 9 2.0 40738 D9Rat130 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Despr5 (maps to same region);Niddm26 (maps to same region) 9 3833388 48833388 5 - by peak with adj size 9 1 42602240 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 9 4986095 49986095 5 - by peak with adj size 9 1254084 46254084 5 - by peak with adj size 2303561 rat Bw91 Body weight QTL 91 17 2.0 36225 D17Rat15 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw32 (maps to same region);Bw67 (maps to same region) 17 11720316 56720316 5 - by peak with adj size 17 15228042 60228042 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 17 9827304 54827304 5 - by peak with adj size 17 8868462 53868462 5 - by peak with adj size 2303563 rat Bw89 Body weight QTL 89 13 6.0 35997 D13Rat26 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 13 42337041 87337041 5 - by peak with adj size 13 34327911 79327911 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 13 37346348 82346348 5 - by peak with adj size 13 32284471 77284471 5 - by peak with adj size 2303564 rat Gluco43 Glucose level QTL 43 8 3.0 36872 D8Rat43 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 8 28742006 73742006 5 - by peak with adj size 8 29077622 74077622 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 8 30144800 75144800 5 - by peak with adj size 8 26130187 71130187 5 - by peak with adj size 2303566 rat Bw90 Body weight QTL 90 16 2.0 42022 D16Arb5 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 16 1 41109533 5 - by peak with adj size 16 1 40096603 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 16 1 41240937 5 - by peak with adj size 16 1 39533930 5 - by peak with adj size 2303568 rat Bw88 Body weight QTL 88 12 3.0 40394 D12Rat89 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw120 (maps to same region);Bw15 (maps to same region) 12 1 26466956 5 - by peak with adj size 12 1 25457135 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303569 rat Gluco44 Glucose level QTL 44 12 2.0 39332 D12Rat52 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm27 (maps to same region) 12 20209592 54450796 5 - by peak with adj size 12 13948769 46782294 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 12 18342477 52716770 5 - by peak with adj size 12 12812385 46669029 5 - by peak with adj size 2303570 rat Gluco48 Glucose level QTL 48 8 2.0 36416 D8Rat31 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 8 52418503 97418503 5 - by peak with adj size 8 53621297 98621297 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 8 55659105 100659105 5 - by peak with adj size 8 49805831 94805831 5 - by peak with adj size 2303571 rat Bw92 Body weight QTL 92 18 3.0 41878 D18Rat121 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 18 51056414 87229863 5 - by peak with adj size 18 51949129 87265094 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 18 51375816 88201929 5 - by peak with adj size 18 48520044 83828827 5 - by peak with adj size 2303572 rat Insul13 Insulin level QTL 13 8 2.0 36872 D8Rat43 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) increased circulating insulin level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm11 (maps to same region) 8 28742006 73742006 5 - by peak with adj size 8 29077622 74077622 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 8 30144800 75144800 5 - by peak with adj size 8 26130187 71130187 5 - by peak with adj size 2303574 rat Gluco42 Glucose level QTL 42 5 2.0 36689 D5Rat14 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive Niddm25 (maps to same region) 5 60025669 105025669 5 - by peak with adj size 5 57040762 102040762 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 5 55903593 100903593 5 - by peak with adj size 5 53496719 98496719 5 - by peak with adj size 2303575 rat Insul14 Insulin level QTL 14 12 4.0 40702 D12Rat69 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) increased circulating insulin level Metabolic Syndrome 2303512;2312611 19697080 additive 12 2495424 47495424 5 - by peak with adj size 12 1 43562201 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 12 492578 45492578 5 - by peak with adj size 12 1 42450532 5 - by peak with adj size 2303576 rat Gluco45 Glucose level QTL 45 1 4.0 39116 D1Rat145 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303577 rat Gluco47 Glucose level QTL 47 5 3.0 40386 D5Rat131 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive Srcrtb2 (maps to same region) 5 16877438 61877438 5 - by peak with adj size 5 12890569 57890569 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303578 rat Gluco50 Glucose level QTL 50 20 2.0 37792 D20Rat29 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 20 28247365 57791882 5 - by peak with adj size 20 25555772 55268282 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 20 26608843 56205956 5 - by peak with adj size 20 25106722 54435887 5 - by peak with adj size 2303579 rat Insul12 Insulin level QTL 12 1 4.0 39116 D1Rat145 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) increased circulating insulin level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm35 (maps to same region) 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303580 rat Gluco49 Glucose level QTL 49 17 2.0 36526 D17Rat46 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 619766 Cdc123 additive 17 55646725 92503511 5 - by peak with adj size 17 61100283 97296363 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 17 53991947 90843779 5 - by peak with adj size 17 50040271 86533673 5 - by peak with adj size 2303581 rat Bw85 Body weight QTL 85 1 4.0 39116 D1Rat145 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw115 (maps to same region);Bw123 (maps to same region);Bw80 (maps to same region);Niddm45 (maps to same region);Niddm58 (maps to same region) 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303582 rat Gluco53 Glucose level QTL 53 7 3.0 36731 D7Rat24 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm19 (maps to same region);Sradr5 (maps to same region) intercross 61105 61109 WKY/NHsd F344/NHsd 2303584 rat Gluco55 Glucose level QTL 55 18 2.0 41878 D18Rat121 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive 18 51056414 87229863 5 - by peak with adj size 18 51949129 87265094 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 18 51375816 88201929 5 - by peak with adj size 18 48520044 83828827 5 - by peak with adj size 2303585 rat Bw86 Body weight QTL 86 4 4.0 39194 D4Rat115 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 4 12496123 57496123 5 - by peak with adj size 4 11706134 56706134 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 4 12638974 57638974 5 - by peak with adj size 4 14678065 59678065 5 - by peak with adj size 2303586 rat Gluco52 Glucose level QTL 52 5 2.0 40262 D5Rat157 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm30 (maps to same region) intercross 61105 61109 WKY/NHsd F344/NHsd 2303587 rat Bw93 Body weight QTL 93 20 13.0 37792 D20Rat29 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 20 28247365 57791882 5 - by peak with adj size 20 25555772 55268282 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 20 26608843 56205956 5 - by peak with adj size 20 25106722 54435887 5 - by peak with adj size 2303589 rat Bw87 Body weight QTL 87 10 2.0 41042 D10Rat134 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw57 (maps to same region) 10 84714875 112200500 5 - by peak with adj size 10 86057484 110718848 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 10 85079943 112626471 5 - by peak with adj size 10 81285008 107211142 5 - by peak with adj size 2303591 rat Gluco41 Glucose level QTL 41 1 2.0 35057 D1Rat39 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm23 (maps to same region) 1 110672269 155672269 5 - by peak with adj size 1 103483490 148483490 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 1 109634374 154634374 5 - by peak with adj size 1 102168504 147168504 5 - by peak with adj size 2303592 rat Gluco51 Glucose level QTL 51 1 3.0 39116 D1Rat145 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm1 (maps to same region);Niddm24 (maps to same region);Niddm35 (maps to same region);Niddm44 (maps to same region);Niddm64 (maps to same region);Niddm65 (maps to same region);Niddm66 (maps to same region);Niddm7 (maps to same region) 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303593 rat Gluco46 Glucose level QTL 46 3 3.0 41162 D3Rat181 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive Despr11 (maps to same region);Srcrt2 (maps to same region) 3 36534996 81534996 5 - by peak with adj size 3 25754538 70754538 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 3 29908255 74908255 5 - by peak with adj size 3 28468571 73468571 5 - by peak with adj size 2303615 rat Vencon7 Ventilatory control QTL 7 5 0.001 38740 D5Rat113 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 5 57457500 102457500 5 - by peak with adj size 5 54207464 99207464 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 5 53309568 98309568 5 - by peak with adj size 5 50983895 95983895 5 - by peak with adj size 2303618 rat Vencon1 Ventilatory control QTL 1 5 3.8 40262 D5Rat157 respiration trait (VT:0001943) oxygen consumption (CMO:0002169) 2303609 intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 2303620 rat Vencon4 Ventilatory control QTL 4 3 3.9 36826 D3Rat12 36745 D3Rat1 36826 D3Rat12 respiration trait (VT:0001943) tidal volume (CMO:0000222) 2303609 3 139333901 180128021 1 - by flanking markers 3 127988419 170016653 1 - by flanking markers intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 3 132875075 176418101 1 - by flanking markers 3 127162703 168026850 1 - by flanking markers 2303622 rat Vencon6 Ventilatory control QTL 6 1 0.001 37870 D1Rat170 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 1 177035811 222035811 5 - by peak with adj size 1 158856292 203856292 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 1 169971964 214971964 5 - by peak with adj size 1 154561505 199561505 5 - by peak with adj size 2303623 rat Vencon2 Ventilatory control QTL 2 4 3.8 36926 D4Rat66 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 2303609 4 201935420 246935420 5 - by peak with adj size 4 138523557 183523557 5 - by peak with adj size 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 4 134917642 179917642 5 - by peak with adj size 4 135204660 180204660 5 - by peak with adj size 2303624 rat Vencon5 Ventilatory control QTL 5 6 4.45 35198 D6Rat11 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 2303609 6 102134434 147134434 5 - by peak with adj size 6 92738204 137738204 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 6 92879510 137879510 5 - by peak with adj size 6 88047916 133047916 5 - by peak with adj size 2303626 rat Vencon10 Ventilatory control QTL 10 20 0.001 38760 D20Rat39 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 20 22585245 57791882 5 - by peak with adj size 20 19840721 55268282 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 20 20858470 56205956 5 - by peak with adj size 20 19190721 54435887 5 - by peak with adj size 2303627 rat Vencon8 Ventilatory control QTL 8 17 0.001 34827 D17Rat12 respiration trait (VT:0001943) tidal volume (CMO:0000222) 2303609 17 7105265 52105265 5 - by peak with adj size 17 10777341 55777341 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 17 5191047 50191047 5 - by peak with adj size 17 4528038 49528038 5 - by peak with adj size 2303628 rat Vencon9 Ventilatory control QTL 9 19 0.005 35547 D19Rat25 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 2303609 19 20855340 65855340 5 - by peak with adj size 19 8121935 53121935 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 2303629 rat Vencon3 Ventilatory control QTL 3 7 7.25 39016 D7Rat103 36099 D7Rat25 41106 D7Rat147 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 7 47909781 63596644 1 - by flanking markers 7 44462790 60576660 1 - by flanking markers intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 7 47895099 63372754 1 - by flanking markers 7 41109692 56793354 1 - by flanking markers 2305926 rat Iddm37 Insulin dependent diabetes mellitus QTL 37 20 6.0 40208 D20Rat47 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) insulitis type 1 diabetes mellitus 2305925;2313174 19720792 69418 Ubd additive Iddm14 (interacts with) 20 4059279 49059279 4 - by one flank marker only 20 1616332 46616332 4 - by one flank marker only 2313181 2313209 LEW.1WR1/WorBrm WF.ART2/Wor 20 2018654 47018654 4 - by one flank marker only 20 1527842 46527842 4 - by one flank marker only 2306545 rat Iddm39 Insulin dependent diabetes mellitus QTL 39 4 43814 D4Got59 738065 D4Rhw6 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased susceptibility to autoimmune diabetes;insulitis type 1 diabetes mellitus 2306526;6480201 19351909;21925515 628765;628871;1305041;1564570;1565750 Gimap4;Gimap5;Gimap6;Gimap8;Gimap7 4 142703528 143059388 1 - by flanking markers 4 76492967 76829366 1 - by flanking markers 2306543 BBDR.F344-(D4Got59-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw 4 78039977 78371222 1 - by flanking markers 4 77356721 77687411 1 - by flanking markers 2306547 rat Iddm38 Insulin dependent diabetes mellitus QTL 38 4 39266 D4Rat102 36181 D4Rat26 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased susceptibility to autoimmune diabetes;insulitis type 1 diabetes mellitus 2306526 19351909 4 66205169 135563631 1 - by flanking markers 4 66220947 69183485 1 - by flanking markers 2306533 BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/2Rhw 4 66394000 70773654 1 - by flanking markers 4 67386669 70362197 1 - by flanking markers 2306787 rat Ean3 Experimental allergic neuritis QTL 3 10 3.1 11479 D10Mit8 41468 D10Rat155 1637892 D10Got236 nervous system integrity trait (VT:0010566) body weight loss (CMO:0001399) demyelination;muscle weakness;weight loss Body Weight Changes;Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 Cia27 (maps to same region);Eae18a (maps to same region) 10 55422036 69020609 1 - by flanking markers 10 55851702 70229954 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 10 55678976 69385767 1 - by flanking markers 10 53797385 66979128 1 - by flanking markers 2306789 rat Ean6 Experimental allergic neuritis QTL 6 12 4.9 11051 D12Mit2 36025 D12Rat23 44974 D12Got48 nervous system integrity trait (VT:0010566) experimental autoimmune neuritis severity score (CMO:0001528) demyelination;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 61307 Ncf1 Eae5 (maps to same region);Pia4 (maps to same region) 12 24662983 29163190 1 - by flanking markers 12 20932559 25367251 1 - by flanking markers 2306784 Kini:DA,PVG-G12 12 22650702 27190240 1 - by flanking markers 12 19610870 24139202 1 - by flanking markers 2306790 rat Ean1 Experimental allergic neuritis QTL 1 20 0.05 nervous system integrity trait (VT:0010566) experimental autoimmune neuritis severity score (CMO:0001528) demyelination;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306736 15342198 intercross 737657 LEW.1AV1 2306792 rat Ean4 Experimental allergic neuritis QTL 4 10 4.0 39750 D10Rat190 66715 D10Mco15 40628 D10Rat142 nervous system integrity trait (VT:0010566) IFNG-secreting splenocyte count (CMO:0002122) abnormal interferon-gamma secretion;demyelination;increased T cell proliferation;increased activated T cell number;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 co-recessive Oia4 (maps to same region) 10 86774898 97028928 1 - by flanking markers 10 87849516 98392508 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 10 86977861 97308569 1 - by flanking markers 10 84022321 93995963 1 - by flanking markers 2306793 rat Ean5 Experimental allergic neuritis QTL 5 10 4.7 66715 D10Mco15 39114 D10Rat87 39114 D10Rat87 nervous system integrity trait (VT:0010566) IFNG-secreting splenocyte count (CMO:0002122) abnormal interferon-gamma secretion;demyelination;increased T cell proliferation;increased activated T cell number;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 Oia3 (maps to same region) 10 75057195 97028717 1 - by flanking markers 10 76043832 98392296 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 10 75045391 97308358 1 - by flanking markers 10 72552416 93995749 1 - by flanking markers 2306794 rat Ean2 Experimental allergic neuritis QTL 2 4 6.4 38262 D4Rat103 36978 D4Rat38 40586 D4Rat231 nervous system integrity trait (VT:0010566) IFNG-secreting splenocyte count (CMO:0002122) abnormal interferon-gamma secretion;demyelination;increased T cell proliferation;increased activated T cell number;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 Cia3 (maps to same region) 4 149135946 162264045 1 - by flanking markers 4 82700691 96313512 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 4 84475257 97479149 1 - by flanking markers 4 83428419 95853334 1 - by flanking markers 2306821 rat Bp335 Blood pressure QTL 335 7 0.001 1627404 D7Mco19 66604 D7Mco7 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 629613;2306800 12682779;19255363 2453;62037;1306132;1306316;1307850;1312017;1359378 Cyp11b1;Arc;Ly6d;Jrk;Gml;Lynx1;Them6 Bp169 (sub_region);Bp285 (interacts with);Bp286 (interacts with) 7 115828017 116100169 1 - by flanking markers 7 112800232 113014423 1 - by flanking markers intercross 2306816 SS.SR-(D7Mco19-D7Mco7)/Jr 7 115922628 145729302 4 - by one flank marker only 7 106571501 135012528 4 - by one flank marker only 2306850 rat Pia40 Pristane induced arthritis QTL 40 20 1.0E-4 41466 D20Rat45 40208 D20Rat47 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) decreased susceptibility to induced joint inflammation;joint inflammation Experimental Arthritis 2306838 19180494 20 4059395 8810219 1 - by flanking markers 20 1616449 5447380 1 - by flanking markers intercross 2306842 E3.DA-(D20Rat45-D20Rat47)/Rhd 20 2018770 6567419 1 - by flanking markers 20 1527959 5304575 1 - by flanking markers 2306899 rat Bp338 Blood pressure QTL 338 4 0.071 36870 D4Rat33 35635 D4Rat54 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 codominant Bp21 (maps to same region) 4 146540904 184799673 1 - by flanking markers 4 80205349 121829076 1 - by flanking markers intercross 2306894 SHR.BN-(D4Rat33-D4Rat54)/Jk 4 81874073 119546974 1 - by flanking markers 4 81006124 120102625 1 - by flanking markers 2306901 rat Bp337 Blood pressure QTL 337 2 0.01 40954 D2Rat226 36081 D2Rat294 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 recessive Bp19 (maps to same region) 2 197020226 262435073 1 - by flanking markers 2 170338294 236153712 1 - by flanking markers intercross 2306895 SHR.BN-(D2Rat226-D2Rat294)/Jk 2 177680772 243901375 1 - by flanking markers 2 164073756 227146641 1 - by flanking markers 2306902 rat Bp339 Blood pressure QTL 339 16 0.01 40724 D16Rat87 34066 D16Mgh1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 recessive Bp23 (maps to same region) 16 4082652 45651269 1 - by flanking markers 16 3464719 46137590 1 - by flanking markers intercross 2306893 SHR.BN-(D16Rat87-D16Mgh1)/Jk 16 4136355 45905331 1 - by flanking markers 16 3380150 43025077 1 - by flanking markers 2306903 rat Bp336 Blood pressure QTL 336 2 0.01 37558 D2Rat114 37952 D2Rat123 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 codominant Bp18 (maps to same region) 2 55361257 131889716 1 - by flanking markers 2 36432989 112326568 1 - by flanking markers intercross 2306892 SHR.BN-(D2Rat114-D2Rat123)/Jk 2 36245223 112175725 1 - by flanking markers 2 64366971 109366971 4 - by one flank marker only 2306968 rat Anxrr23 Anxiety related response QTL 23 15 4.83 34910 D15Rat14 35611 D15Rat11 45269 D15Wox3 reflex trait (VT:0001961) amplitude of the acoustic startle response (CMO:0001520) increased anxiety-related response 625384;10053640 11932246;21029000 additive Srcrt8 (maps to same region) 15 48493430 56554042 1 - by flanking markers 15 45870097 51526246 1 - by flanking markers intercross 2306961 2306962 RLA/Verh RHA/Verh 15 43097470 52831189 1 - by flanking markers 15 40631268 46187442 1 - by flanking markers 2306970 rat Anxrr22 Anxiety related response QTL 22 10 5.95 34445 D10Mgh6 38844 D10Rat101 36019 D10Rat18 fear/anxiety-related behavior trait (VT:1000241) number of periods of voluntary immobility (CMO:0001045) increased anxiety-related response 625384 11932246 additive 10 63366082 101365609 1 - by flanking markers 10 67677924 102796362 1 - by flanking markers intercross 2306961 2306962 RLA/Verh RHA/Verh 10 64648175 101691360 1 - by flanking markers 10 61345276 98211570 1 - by flanking markers 2306971 rat Anxrr21 Anxiety related response QTL 21 5 9.47 38768 D5Rat100 60485 D5Got42 43930 D5Wox4 fear/anxiety-related behavior trait (VT:1000241) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased grooming behavior;impaired passive avoidance behavior;increased anxiety-related response 2313899;625384 18971309;11932246 additive 5 70180341 132878299 1 - by flanking markers 5 68843563 130756605 1 - by flanking markers intercross 2306961 2306962 RLA/Verh RHA/Verh 5 65696672 129038896 1 - by flanking markers 5 66174080 124160948 1 - by flanking markers 2307172 rat Activ4 Activity QTL 4 16 3.71 2.3E-4 39200 D16Rat32 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity;increased exploration in new environment acute stress disorder 2306974 19089625 16 1 32781388 5 - by peak with adj size 16 1 33735317 5 - by peak with adj size intercross 61008 2292168 WAG ISIAH 16 1 34465490 5 - by peak with adj size 16 1 33418960 5 - by peak with adj size 2307174 rat Activ3 Activity QTL 3 2 4.83 5.8E-5 38280 D2Rat157 36876 D2Rat88 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity;increased exploration in new environment acute stress disorder 2306974 19089625 2 241761764 248335979 1 - by flanking markers 2 216711618 222281918 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 2 183984665 228984665 4 - by one flank marker only 2 168594495 213594495 4 - by one flank marker only 2312418 rat Kidm41 Kidney mass QTL 41 12 3.7 1.0E-4 11052 D12Wox11 41958 D12Arb14 kidney mass (VT:0002707) single kidney wet weight to body weight ratio (CMO:0000622) decreased kidney weight anti-basement membrane glomerulonephritis 2312387 19448344 recessive 12 4344844 24663198 2 - by one flank and peak markers 12 665384 20932760 2 - by one flank and peak markers 61111 1358112 DA/Slc WKY/NCrl 12 1 22650917 4 - by one flank marker only 12 1 19611090 4 - by one flank marker only 2312420 rat Pur17 Proteinuria QTL 17 1 7.1 1.0E-4 36105 D1Rat51 33945 D1Mit18 37732 D1Rat208 urine protein amount (VT:0005160) urine total protein excretion rate (CMO:0000756) increased urine protein level anti-basement membrane glomerulonephritis;proteinuria 2312387 19448344 recessive 1 173583273 246119106 1 - by flanking markers 1 159782445 224426393 1 - by flanking markers backcross 61111 1358112 DA/Slc WKY/NCrl 1 167394665 238830534 1 - by flanking markers 1 156677124 218753816 1 - by flanking markers 2312558 rat Glom17 Glomerulus QTL 17 1 3.9 0.001 37834 D1Rat164 39462 D1Rat289 39314 D1Rat216 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 1 184213481 215717121 1 - by flanking markers 1 170218208 201628746 2 - by one flank and peak markers backcross 737905 1331815 LEW/Maas LEW/Mol 1 177235071 208786962 1 - by flanking markers 1 166532971 191278129 1 - by flanking markers 2312560 rat Pur20 Proteinuria QTL 20 6 2.1 0.005 38282 D6Rat79 37076 D6Rat1 37076 D6Rat1 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) cortical renal glomerulopathies;increased urine protein level focal segmental glomerulosclerosis;proteinuria 2312422 18682577 6 139739945 153672040 1 - by flanking markers 6 131029751 144152572 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 6 130561943 144745573 1 - by flanking markers 6 125628133 137801795 1 - by flanking markers 2312562 rat Pur18 Proteinuria QTL 18 5 2.6 0.001 38744 D5Rat116 40256 D5Rat190 40250 D5Rat125 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) cortical renal glomerulopathies;increased urine protein level focal segmental glomerulosclerosis;proteinuria 2312422 18682577 5 1521341 29109277 1 - by flanking markers 5 1220773 24978263 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 5 1525098 33001026 2 - by one flank and peak markers 5 2138965 32656739 2 - by one flank and peak markers 2312564 rat Glom18 Glomerulus QTL 18 1 2.4 0.003 41012 D1Rat287 36950 D1Rat77 37162 D1Rat72 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 1 208389496 259703697 1 - by flanking markers 1 190114247 238037551 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 1 201358068 252480016 1 - by flanking markers 1 185356336 231689108 1 - by flanking markers 2312566 rat Glom20 Glomerulus QTL 20 11 3.6 0.001 36065 D11Rat6 10375 D11Mgh1 38558 D11Rat64 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 11 49765505 89808503 1 - by flanking markers 11 45232526 84560241 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 11 46583209 86714631 1 - by flanking markers 11 44285759 82566702 1 - by flanking markers 2312567 rat Glom19 Glomerulus QTL 19 4 1.9 0.006 41458 D4Rat153 36143 D4Rat60 35325 D4Rat41 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 4 116181405 208908285 2 - by one flank and peak markers 4 43686352 149560340 2 - by one flank and peak markers backcross 737905 1331815 LEW/Maas LEW/Mol 4 49906054 145611886 2 - by one flank and peak markers 4 45456990 146803430 2 - by one flank and peak markers 2312568 rat Glom21 Glomerulus QTL 21 18 2.0 0.005 35511 D18Rat31 37608 D18Rat53 35511 D18Rat31 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 18 5401204 41422831 1 - by flanking markers 18 5270273 42006239 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 18 5430134 41781619 1 - by flanking markers 18 5185858 40503530 1 - by flanking markers 2312569 rat Pur19 Proteinuria QTL 19 4 3.4 0.001 41458 D4Rat153 35325 D4Rat41 36870 D4Rat33 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) cortical renal glomerulopathies;increased urine protein level focal segmental glomerulosclerosis;proteinuria 2312422 18682577 4 130537030 162544932 2 - by one flank and peak markers 4 63787419 96623433 2 - by one flank and peak markers backcross 737905 1331815 LEW/Maas LEW/Mol 4 65989243 97759057 2 - by one flank and peak markers 4 65882107 96130297 2 - by one flank and peak markers 2312598 rat Bp340 Blood pressure QTL 340 18 0.05 39518 D18Rat113 40782 D18Rat99 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial diastolic blood pressure;increased systemic arterial systolic blood pressure hypertension 2312571 19620519 18 1 32165443 4 - by one flank marker only 18 1 31654862 4 - by one flank marker only intercross 2312580 SHR.BN-(D18Rat113-D18Rat82)/Ipcv 18 3719547 32487870 1 - by flanking markers 18 1 30558703 4 - by one flank marker only 2312600 rat Bp341 Blood pressure QTL 341 18 0.05 37412 D18Rat40 41356 D18Rat82 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2312571 19620519 18 60695794 72695235 1 - by flanking markers 18 62106066 73666623 1 - by flanking markers 2312579 SHR.BN-(D18Rat40-D18Rat82)/Ipcv 18 61499531 73016546 1 - by flanking markers 18 59330409 70263868 1 - by flanking markers 2312659 rat Slep7 Serum leptin concentration QTL 7 3 0.001 34228 D3Mgh5 36745 D3Rat1 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 2312642 19584880 61883;61965 Ghrh;Ptpn1 BW17_H (maps to syntenic region);Bw94 (maps to same region);Mlepq1_m (maps to syntenic region) 3 109733850 180128021 1 - by flanking markers 3 97523869 170016653 1 - by flanking markers intercross 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K 3 103141814 176418101 1 - by flanking markers 3 98535255 168026850 1 - by flanking markers 2312660 rat Bw95 Body weight QTL 95 16 0.05 39456 D16Rat88 45369 D16Wox7 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) increased total body fat amount Metabolic Syndrome 2312642 19584880 Insul16 (maps to same region);Slep9 (maps to same region);Stl23 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312662 rat Slep8 Serum leptin concentration QTL 8 10 0.05 34330 D10Mgh2 35665 D10Rat4 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 2312642 19584880 621087 Socs3 Insul15 (maps to same region);Scl65 (maps to same region) 10 60533612 105533612 4 - by one flank marker only 10 106422174 107033716 1 - by flanking markers intercross 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K 10 60875260 105875260 4 - by one flank marker only 10 57134272 102134272 4 - by one flank marker only 2312663 rat Slep9 Serum leptin concentration QTL 9 16 0.001 39456 D16Rat88 45369 D16Wox7 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 2312642 19584880 Bw95 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312664 rat Scl62 Serum cholesterol level QTL 62 3 0.05 33782 D3Mit10 37588 D3Rat189 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 3 1 44863303 4 - by one flank marker only 3 1 35797756 4 - by one flank marker only intercross 2312644 DA.WOKW-(D3Mit10-D3Rat189)/K 3 1 39773425 4 - by one flank marker only 3 1 38710544 4 - by one flank marker only 2312666 rat Insul16 Insulin level QTL 16 16 0.01 39456 D16Rat88 45369 D16Wox7 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 2312642 19584880 Bw95 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312668 rat Scl65 Serum cholesterol level QTL 65 10 0.001 34330 D10Mgh2 35665 D10Rat4 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 Slep8 (maps to same region) 10 60533612 105533612 4 - by one flank marker only 10 106422174 107033716 1 - by flanking markers intercross 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K 10 60875260 105875260 4 - by one flank marker only 10 57134272 102134272 4 - by one flank marker only 2312669 rat Stl23 Serum triglyceride level QTL 23 16 0.01 39456 D16Rat88 45369 D16Wox7 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 Bw95 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312670 rat Bw94 Body weight QTL 94 3 0.01 34228 D3Mgh5 36745 D3Rat1 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) increased total body fat amount Metabolic Syndrome 2312642 19584880 61883;61965 Ghrh;Ptpn1 BW17_H (maps to syntenic region);Mlepq1_m (maps to syntenic region);Scl63 (maps to same region);Slep7 (maps to same region) 3 109733850 180128021 1 - by flanking markers 3 97523869 170016653 1 - by flanking markers intercross 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K 3 103141814 176418101 1 - by flanking markers 3 98535255 168026850 1 - by flanking markers 2312671 rat Scl64 Serum cholesterol level QTL 64 5 0.001 34216 D5Mgh6 34041 D5Mit5 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 Mbsyd_m (maps to syntenic region);Scl20 (maps to same region) 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers intercross 2312646 DA.WOKW-(D5Mgh6-D5Mit5)/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 2312672 rat Insul15 Insulin level QTL 15 10 0.01 34330 D10Mgh2 35665 D10Rat4 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 2312642 19584880 621087 Socs3 Slep8 (maps to same region) 10 60533612 105533612 4 - by one flank marker only 10 106422174 107033716 1 - by flanking markers intercross 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K 10 60875260 105875260 4 - by one flank marker only 10 57134272 102134272 4 - by one flank marker only 2312673 rat Scl63 Serum cholesterol level QTL 63 3 0.001 34228 D3Mgh5 36745 D3Rat1 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 61883;61965 Ghrh;Ptpn1 BW17_H (maps to syntenic region);Bw94 (maps to same region);Mlepq1_m (maps to syntenic region) 3 109733850 180128021 1 - by flanking markers 3 97523869 170016653 1 - by flanking markers intercross 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K 3 103141814 176418101 1 - by flanking markers 3 98535255 168026850 1 - by flanking markers 2313046 rat Bss78 Bone structure and strength QTL 78 8 3.5 1.0E-4 33559 D8Mit5 34310 D8Mgh4 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss75 (maps to same region);Bss76 (maps to same region);Bss77 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313048 rat Bss84 Bone structure and strength QTL 84 14 3.1 1.0E-4 33692 D14Mit12 60700 D14Mgh11 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss81 (maps to same region);Bss82 (maps to same region);Bss83 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313049 rat Bss72 Bone structure and strength QTL 72 3 2.6 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bmd77 (maps to same region);Bss73 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313051 rat Bss57 Bone structure and strength QTL 57 1 3.7 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313053 rat Bss51 Bone structure and strength QTL 51 1 3.8 1.0E-4 37984 D1Rat232 36640 D1Rat14 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd69 (maps to same region);Bss52 (maps to same region) 1 1 36395668 4 - by one flank marker only 17 1 2481129 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 1 34993530 4 - by one flank marker only 1 1 32356093 4 - by one flank marker only 2313055 rat Bw96 Body weight QTL 96 10 3.6 1.0E-4 33666 D10Mit16 33891 D10Mit5 body mass (VT:0001259) body weight (CMO:0000012) increased bone mineral density osteoporosis 2312767 19113924 Bmd80 (maps to same region) 10 19835926 21392459 1 - by flanking markers 10 20018844 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 19958696 21524070 1 - by flanking markers 10 19606483 64606483 4 - by one flank marker only 2313057 rat Bss76 Bone structure and strength QTL 76 8 3.0 1.0E-4 33559 D8Mit5 34310 D8Mgh4 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss75 (maps to same region);Bss77 (maps to same region);Bss78 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313059 rat Bss55 Bone structure and strength QTL 55 1 3.2 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313060 rat Bss71 Bone structure and strength QTL 71 1 2.6 1.0E-4 34134 D1Mgh1 10878 D12Wox9 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone mineral density;decreased bone strength osteoporosis 2312767 19113924 1 125208389 205564501 1 - by flanking markers 1 119780411 186388966 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 124090312 169090312 4 - by one flank marker only 1 118944747 163944747 4 - by one flank marker only 2313062 rat Bmd73 Bone mineral density QTL 73 1 3.9 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313064 rat Bmd71 Bone mineral density QTL 71 10 0.9 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) decreased bone mineral density osteoporosis 2312767 19113924 Bss61 (maps to same region);Bss62 (maps to same region);Bss63 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313065 rat Bss67 Bone structure and strength QTL 67 1 3.1 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia area (VT:1000281) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313066 rat Bss63 Bone structure and strength QTL 63 10 1.4 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss61 (maps to same region);Bss62 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313067 rat Bss77 Bone structure and strength QTL 77 8 3.1 1.0E-4 33559 D8Mit5 34310 D8Mgh4 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss75 (maps to same region);Bss76 (maps to same region);Bss78 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313069 rat Bss68 Bone structure and strength QTL 68 1 2.9 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia size trait (VT:0100001) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313070 rat Bss52 Bone structure and strength QTL 52 1 4.4 1.0E-4 37984 D1Rat232 36640 D1Rat14 body length (VT:0001256) body length (CMO:0000013) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd69 (maps to same region);Bss51 (maps to same region) 1 1 36395668 4 - by one flank marker only 17 1 2481129 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 1 34993530 4 - by one flank marker only 1 1 32356093 4 - by one flank marker only 2313072 rat Bss53 Bone structure and strength QTL 53 1 4.3 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313073 rat Bmd75 Bone mineral density QTL 75 2 4.1 1.0E-4 36173 D10Rat23 34401 D2Mgh22 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 2 250573351 272824647 1 - by flanking markers 2 224179988 247306073 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 2 231224020 254132424 1 - by flanking markers 2 215377404 237938339 1 - by flanking markers 2313075 rat Bss66 Bone structure and strength QTL 66 1 3.4 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313076 rat Bss74 Bone structure and strength QTL 74 3 2.0 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bmd77 (maps to same region);Bss72 (maps to same region);Bss73 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313077 rat Bss69 Bone structure and strength QTL 69 1 3.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313078 rat Bss54 Bone structure and strength QTL 54 1 3.5 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313079 rat Bss73 Bone structure and strength QTL 73 3 1.5 37010 D3Rat49 11260 D3Mit8 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bmd77 (maps to same region);Bss72 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313080 rat Bss65 Bone structure and strength QTL 65 15 3.9 1.0E-4 42006 D15Arb2 34222 D15Mgh8 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 15 71993218 84794402 1 - by flanking markers 15 67190176 80362100 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 15 68366508 81255430 1 - by flanking markers 15 60990468 73690657 1 - by flanking markers 2313081 rat Bss64 Bone structure and strength QTL 64 10 1.3 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss61 (maps to same region);Bss62 (maps to same region);Bss63 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313082 rat Bss85 Bone structure and strength QTL 85 18 0.8 1.0E-4 34059 D18Mit2 34236 D18Mgh5 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 18 14473035 59473035 4 - by one flank marker only 18 15584909 60584909 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 18 14678852 59678852 4 - by one flank marker only 18 14951337 59951337 4 - by one flank marker only 2313083 rat Bmd74 Bone mineral density QTL 74 1 4.0 1.0E-4 10442 D1Wox16 34134 D1Mgh1 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 1 84871364 127336420 1 - by flanking markers 1 81947770 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 83656882 126240667 1 - by flanking markers 1 82174743 118944897 1 - by flanking markers 2313084 rat Bss83 Bone structure and strength QTL 83 14 2.9 1.0E-4 33692 D14Mit12 60700 D14Mgh11 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss81 (maps to same region);Bss82 (maps to same region);Bss84 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313085 rat Bss59 Bone structure and strength QTL 59 5 2.9 1.0E-4 39686 D5Rat119 34639 D5Pas1 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 5 3239567 30952938 1 - by flanking markers 5 2965857 26938988 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5 3251329 26252076 1 - by flanking markers 5 3844018 26141981 1 - by flanking markers 2313086 rat Bss60 Bone structure and strength QTL 60 8 4.1 1.0E-4 33973 D8Mit2 34310 D8Mgh4 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 8 52685897 88595536 1 - by flanking markers 8 53049279 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 54065044 89058369 1 - by flanking markers 8 50095249 82460899 1 - by flanking markers 2313087 rat Bmd80 Bone mineral density QTL 80 10 3.2 1.0E-4 33666 D10Mit16 33891 D10Mit5 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 Bw96 (maps to same region) 10 19835926 21392459 1 - by flanking markers 10 20018844 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 19958696 21524070 1 - by flanking markers 10 19606483 64606483 4 - by one flank marker only 2313088 rat Bss75 Bone structure and strength QTL 75 8 3.1 1.0E-4 33559 D8Mit5 34310 D8Mgh4 body length (VT:0001256) body length, nose to rump (CMO:0000079) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss76 (maps to same region);Bss77 (maps to same region);Bss78 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313089 rat Bss81 Bone structure and strength QTL 81 14 3.4 1.0E-4 33692 D14Mit12 60700 D14Mgh11 body length (VT:0001256) body length, nose to rump (CMO:0000079) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss82 (maps to same region);Bss83 (maps to same region);Bss84 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313090 rat Bmd69 Bone mineral density QTL 69 1 4.4 1.0E-4 37984 D1Rat232 36640 D1Rat14 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) decreased bone mineral density osteoporosis 2312767 19113924 Bss51 (maps to same region);Bss52 (maps to same region) 1 1 36395668 4 - by one flank marker only 17 1 2481129 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 1 34993530 4 - by one flank marker only 1 1 32356093 4 - by one flank marker only 2313092 rat Bmd72 Bone mineral density QTL 72 1 2.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313093 rat Bmd77 Bone mineral density QTL 77 3 2.2 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bss72 (maps to same region);Bss73 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313094 rat Bss58 Bone structure and strength QTL 58 1 3.7 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313095 rat Bss62 Bone structure and strength QTL 62 10 1.5 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss61 (maps to same region);Bss63 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313096 rat Bmd78 Bone mineral density QTL 78 5 3.1 1.0E-4 34136 D5Mgh21 34467 D5Mgh16 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 5 154034053 171522762 1 - by flanking markers 5 151060403 168006088 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5 150360936 167946134 1 - by flanking markers 5 144377876 161317411 1 - by flanking markers 2313097 rat Bss70 Bone structure and strength QTL 70 1 3.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone mineral density;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313098 rat Bmd70 Bone mineral density QTL 70 1 3.6 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) decreased bone mineral density osteoporosis 2312767 19113924 Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313099 rat Bss56 Bone structure and strength QTL 56 1 2.4 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313100 rat Bss82 Bone structure and strength QTL 82 14 3.0 1.0E-4 33692 D14Mit12 60700 D14Mgh11 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss81 (maps to same region);Bss83 (maps to same region);Bss84 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313101 rat Bmd76 Bone mineral density QTL 76 3 3.6 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 Bmd77 (maps to same region);Bss72 (maps to same region);Bss73 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313102 rat Bmd79 Bone mineral density QTL 79 7 2.3 1.0E-4 33969 D7Mit4 33816 D7Mit11 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 7 104385465 126236887 1 - by flanking markers 7 100273558 123635849 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 7 103815550 126525386 1 - by flanking markers 7 94811085 116738842 1 - by flanking markers 2313103 rat Bss80 Bone structure and strength QTL 80 10 2.0 1.0E-4 34110 D10Mgh13 35254 D10Rat2 tibia strength trait (VT:1000284) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss79 (maps to same region) 11 61504312 87759784 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 65992275 110992275 4 - by one flank marker only 10 62057807 107057807 4 - by one flank marker only 2313104 rat Bss61 Bone structure and strength QTL 61 10 0.9 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss62 (maps to same region);Bss63 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313105 rat Bss79 Bone structure and strength QTL 79 10 1.8 1.0E-4 34110 D10Mgh13 35254 D10Rat2 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss80 (maps to same region) 11 61504312 87759784 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 65992275 110992275 4 - by one flank marker only 10 62057807 107057807 4 - by one flank marker only 2313395 rat Anxrr26 Anxiety related response QTL 26 19 36972 D19Rat21 35028 D19Rat2 36972 D19Rat21 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 19 65454505 68775038 1 - by flanking markers 19 52161990 55455363 1 - by flanking markers intercross 2313384 Wild/Nov 19 54735217 58072143 1 - by flanking markers 19 49976481 53225766 1 - by flanking markers 2313397 rat Coatc1 Coat color QTL1 14 7.0 37624 D14Rat68 coat/hair pigmentation trait (VT:0010463) coat/hair color measurement (CMO:0001808) white spotting 2313383 19363126 additive 14 19985846 64985846 5 - by peak with adj size 14 21150250 66150250 5 - by peak with adj size intercross 2313384 Wild/Nov 14 20189386 65189386 5 - by peak with adj size 14 18541332 63541332 5 - by peak with adj size 2313399 rat Anxrr28 Anxiety related response QTL 28 6 42802 D6Rat229 10777 D6Wox11 42809 D6Rat184 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 6 113838592 147058880 2 - by one flank and peak markers 6 99749898 138261655 1 - by flanking markers intercross 2313384 Wild/Nov 6 104381930 138066274 2 - by one flank and peak markers 6 100671796 132340886 2 - by one flank and peak markers 2313400 rat Anxrr25 Anxiety related response QTL 25 8 2.3 41518 D8Rat135 38140 D8Rat72 35537 D8Rat12 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 8 95458335 121667168 1 - by flanking markers 8 93585899 118725315 1 - by flanking markers intercross 2313384 Wild/Nov 8 95963141 122354314 1 - by flanking markers 8 89265192 114019816 1 - by flanking markers 2313401 rat Anxrr27 Anxiety related response QTL 27 4 11378 D4Wox30 10144 D4Mgh16 11378 D4Wox30 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 4 33498841 61427664 1 - by flanking markers 4 32648616 61646915 1 - by flanking markers intercross 2313384 Wild/Nov 4 33637803 61708341 1 - by flanking markers 4 17933508 62933508 4 - by one flank marker only 2313402 rat Anxrr24 Anxiety related response QTL 24 1 5.1 38426 D1Rat191 33959 D1Mit3 10334 D1Wox14 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 additive 1 50601416 162692800 1 - by flanking markers 1 43426139 146971983 1 - by flanking markers intercross 2313384 Wild/Nov 1 49147799 156446783 1 - by flanking markers 1 48963584 144267916 1 - by flanking markers 2313854 rat Bp343 Blood pressure QTL 343 17 3.9 33882 D17Mit2 34120 D17Mgh5 2070 Agtr1a life span trait (VT:0005372) age at time of death (CMO:0001193) abnormal induced morbidity/mortality;abnormal pilomotor reflex;increased systemic arterial blood pressure;lethargy;mortality/aging;seizures;weight loss Polyuria;hypertension;malignant hypertension;malignant hypertension;visual epilepsy 619627 10432379 2070 Agtr1a Bp342 (interacts with) 17 35195242 51171794 1 - by flanking markers 17 38353858 59104944 1 - by flanking markers intercross 629501 1298093 SD-Tg(Ren2)27 LEW/NHsd 17 33303627 53475276 1 - by flanking markers 17 31990784 50909196 1 - by flanking markers 2313856 rat Bp342 Blood pressure QTL 342 10 4.4 1.0E-4 11308 D10Wox20 35256 D10Rat11 2493 Ace life span trait (VT:0005372) age at time of death (CMO:0001193) abnormal induced morbidity/mortality;abnormal pilomotor reflex;increased systemic arterial blood pressure;lethargy;mortality/aging;seizures;weight loss Polyuria;hypertension;malignant hypertension;visual epilepsy 2313695;619627 19307186;10432379 2493 Ace Bp343 (interacts with) 10 90085487 99184250 1 - by flanking markers 10 91455572 100633982 1 - by flanking markers intercross 629501 1298093 SD-Tg(Ren2)27 LEW/NHsd 10 90296897 99492409 1 - by flanking markers 10 87307617 96121100 1 - by flanking markers 2314011 rat Gluco56 Glucose level QTL 56 1 35615 D1Rat70 39982 D1Rat323 36580 D1Rat112 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level hyperglycemia 2316693;9587420 20068026;25236446 1311779 Tpcn2 additive 1 224635116 227059170 1 - by flanking markers 1 205040948 207483209 1 - by flanking markers 2314009 NMcwi:HS 1 217776868 220128172 1 - by flanking markers 1 199773958 202166723 1 - by flanking markers 2316649 rat Bp344 Blood pressure QTL 344 1 2315162 D1Mco102 2315160 D1Mco129 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2312639;9685377 19423552;25231251 1309747;1310046 Ice1;Adamts16 BP47_H (maps to syntenic region);Bp153 (sub_region) 1 36290530 37078065 1 - by flanking markers 17 2374083 3178843 1 - by flanking markers 2316654 2316655 SS.LEW-(D1Mco102-D1Mco129)/1Mco SS.LEW-(D1Mco102-D1Mco129)/2Mco 1 34888392 35680732 1 - by flanking markers 1 32249735 33038814 1 - by flanking markers 2316896 rat Gluco57 Glucose level QTL 57 1 7.2 35945 D1Rat75 10805 D1Mgh13 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 1 256846704 274224361 1 - by flanking markers 1 235098616 252340527 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 1 249607907 266793958 1 - by flanking markers 1 228985440 245907899 1 - by flanking markers 2316947 rat Rf58 Renal function QTL 58 7 7.8 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) kidney failure focal segmental glomerulosclerosis;kidney failure;type 2 diabetes mellitus 2316856 19584172 Pur22 (maps to same region) 7 77892975 123587717 2 - by one flank and peak markers 7 72552109 120746007 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 7 55072862 123602998 1 - by flanking markers 7 68938720 113886318 2 - by one flank and peak markers 2316949 rat Gluco60 Glucose level QTL 60 10 3.7 33585 D10Mit6 35254 D10Rat2 35503 D10Rat20 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 10 14644150 110568670 1 - by flanking markers 10 14721135 110718848 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 10 14827894 110992275 1 - by flanking markers 10 14487011 107057807 1 - by flanking markers 2316950 rat Scl66 Serum cholesterol level QTL 66 8 4.1 34062 D8Mgh2 33559 D8Mit5 35899 D8Rat47 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level familial hyperlipidemia;type 2 diabetes mellitus 2316856 19584172 8 33603128 112967014 1 - by flanking markers 8 32203499 110106272 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 8 33558764 113580387 1 - by flanking markers 8 30848259 105647037 1 - by flanking markers 2316952 rat Pur22 Proteinuria QTL 22 7 5.2 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 urine protein amount (VT:0005160) urine protein level (CMO:0000591) increased urine protein level proteinuria;type 2 diabetes mellitus 2316856 19584172 Rf58 (maps to same region) 7 77892975 123587717 2 - by one flank and peak markers 7 72552109 120746007 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 7 55072862 123602998 1 - by flanking markers 7 68938720 113886318 2 - by one flank and peak markers 2316954 rat Rf57 Renal function QTL 57 5 0.0 33981 D5Mit4 34322 D5Mgh10 34144 D5Mgh11 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) kidney failure focal segmental glomerulosclerosis;kidney failure;type 2 diabetes mellitus 2316856 19584172 5 65595291 97315057 1 - by flanking markers 5 62098775 94515803 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 5 61086653 93273130 1 - by flanking markers 5 59793528 90450144 1 - by flanking markers 2316955 rat Stl24 Serum triglyceride level QTL 24 7 7.1 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level familial hyperlipidemia;type 2 diabetes mellitus 2316856 19584172 7 77892975 123587717 2 - by one flank and peak markers 7 72552109 120746007 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 7 55072862 123602998 1 - by flanking markers 7 68938720 113886318 2 - by one flank and peak markers 2316957 rat Pur21 Proteinuria QTL 21 5 6.2 35306 D5Rat26 34322 D5Mgh10 35144 D5Rat13 urine protein amount (VT:0005160) urine protein level (CMO:0000591) increased urine protein level proteinuria;type 2 diabetes mellitus 2316856 19584172 additive 5 65595291 121495621 1 - by flanking markers 5 62098775 119332868 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 5 61086653 117554114 1 - by flanking markers 5 59793528 113558156 1 - by flanking markers 2316958 rat Gluco58 Glucose level QTL 58 4 10.0 35895 D4Rat1 37340 D4Rat84 35797 D4Rat16 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 4 7858962 246313537 1 - by flanking markers 4 6690606 185398530 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 4 7850904 182171018 1 - by flanking markers 4 11320076 180699135 1 - by flanking markers 2316959 rat Gluco59 Glucose level QTL 59 5 4.7 35306 D5Rat26 11072 D5Mgh2 34144 D5Mgh11 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 recessive 5 21842328 121495621 1 - by flanking markers 5 17517235 119332868 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 5 35661945 117554267 2 - by one flank and peak markers 5 34944474 113558310 2 - by one flank and peak markers 2317027 rat Aia22 Adjuvant induced arthritis QTL 22 13 2.29 6.1 35975 D13Rat7 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 1 42018230 5 - by peak with adj size 13 1 23584369 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 13 1 36779181 5 - by peak with adj size 13 1 34266636 5 - by peak with adj size 2317029 rat Aia19 Adjuvant induced arthritis QTL 19 10 2.98 8.8 41468 D10Rat155 36319 D10Rat26 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 10 69020437 112200500 4 - by one flank marker only 10 70229781 110718848 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 69385595 112626471 4 - by one flank marker only 10 66978955 107211142 4 - by one flank marker only 2317030 rat Wbc5 White blood cell count QTL 5 8 3.21 0.005 9.0 42244 D8Arb6 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) decreased leukocyte cell number inflammatory bowel disease;leukopenia 2316974 19526527 recessive 8 11490219 56490219 5 - by peak with adj size 8 10116155 55116155 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 11448251 56448251 5 - by peak with adj size 8 8736635 53736635 5 - by peak with adj size 2317032 rat Ginf2 Gastrointestinal inflammation QTL 2 8 3.21 0.005 9.0 41522 D8Rat164 liver integrity trait (VT:0010547) liver granuloma severity score (CMO:0002157) granulomatous inflammation;intestinal inflammation Enterocolitis;inflammatory bowel disease 2316974 19526527 recessive 8 7378774 52378774 5 - by peak with adj size 8 5914098 50914098 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 7368076 52368076 5 - by peak with adj size 8 4705810 49705810 5 - by peak with adj size 2317034 rat Aia9 Adjuvant induced arthritis QTL 9 13 4.62 12.8 35975 D13Rat7 40662 D13Rat113 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19518130 42226993 1 - by flanking markers 13 1084268 33188609 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 13 14279081 37124697 1 - by flanking markers 13 11766535 32331607 1 - by flanking markers 2317035 rat Aia16 Adjuvant induced arthritis QTL 16 7 2.71 9.5 36731 D7Rat24 37374 D7Rat99 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 7 68456672 113456672 4 - by one flank marker only 7 65025373 110025373 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 7 68518460 113518460 4 - by one flank marker only 7 59238038 104238038 4 - by one flank marker only 2317036 rat Livw3 Liver weight QTL 3 8 2.43 0.01 7.1 41522 D8Rat164 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) decreased liver weight inflammatory bowel disease 2316974 19526527 additive 8 7378774 52378774 5 - by peak with adj size 8 5914098 50914098 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 7368076 52368076 5 - by peak with adj size 8 4705810 49705810 5 - by peak with adj size 2317038 rat Ginf3 Gastrointestinal inflammation QTL 3 17 2.89 0.005 8.4 37926 D17Rat62 liver integrity trait (VT:0010547) liver granuloma severity score (CMO:0002157) granulomatous inflammation;intestinal inflammation Enterocolitis;inflammatory bowel disease 2316974 19526527 dominant 17 55528137 92503511 5 - by peak with adj size 17 60979997 97296363 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 17 53871488 90843779 5 - by peak with adj size 17 49920154 86533673 5 - by peak with adj size 2317039 rat Aia6 Adjuvant induced arthritis QTL 6 10 4.31 13.8 41468 D10Rat155 36319 D10Rat26 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 recessive 10 69020437 112200500 4 - by one flank marker only 10 70229781 110718848 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 69385595 112626471 4 - by one flank marker only 10 66978955 107211142 4 - by one flank marker only 2317040 rat Aia21 Adjuvant induced arthritis QTL 21 13 2.75 7.3 40662 D13Rat113 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19726927 64726927 5 - by peak with adj size 13 10688543 55688543 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 13 14624631 59624631 5 - by peak with adj size 13 9831541 54831541 5 - by peak with adj size 2317041 rat Aia14 Adjuvant induced arthritis QTL 14 2 3.29 8.6 36093 D2Rat26 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 additive 2 91248901 136248901 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 2 71495404 116495404 5 - by peak with adj size 2317042 rat Aia20 Adjuvant induced arthritis QTL 20 10 3.38 12.0 36319 D10Rat26 34274 D10Mgh5 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 10 40302564 85302564 4 - by one flank marker only 10 41317054 86317054 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 40514044 85514044 4 - by one flank marker only 10 37565079 82565079 4 - by one flank marker only 2317043 rat Aia7 Adjuvant induced arthritis QTL 7 10 3.82 12.6 36319 D10Rat26 34274 D10Mgh5 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 10 40302564 85302564 4 - by one flank marker only 10 41317054 86317054 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 40514044 85514044 4 - by one flank marker only 10 37565079 82565079 4 - by one flank marker only 2317044 rat Aia23 Adjuvant induced arthritis QTL 23 13 2.3 6.5 35975 D13Rat7 40662 D13Rat113 joint integrity trait (VT:0010548) ankle joint diameter (CMO:0002148) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19518130 42226993 1 - by flanking markers 13 1084268 33188609 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 13 14279081 37124697 1 - by flanking markers 13 11766535 32331607 1 - by flanking markers 2317045 rat Aia11 Adjuvant induced arthritis QTL 11 17 4.06 11.5 35585 D17Rat151 39044 D17Rat89 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 17 65440692 71966023 1 - by flanking markers 17 71569891 77806121 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 17 63675975 70261772 1 - by flanking markers 17 60781426 86533673 4 - by one flank marker only 2317046 rat Aia8 Adjuvant induced arthritis QTL 8 13 3.9700000286102295 10.399999618530273 40662 D13Rat113 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19726927 64726927 5 - by peak with adj size 13 10688543 55688543 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 13 14624631 59624631 5 - by peak with adj size 13 9831541 54831541 5 - by peak with adj size 2317047 rat Wbc4 White blood cell count QTL 4 7 0.01 38322 D7Rat63 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) decreased leukocyte cell number inflammatory bowel disease;leukopenia 2316974 19526527 7 1 38285714 5 - by peak with adj size 7 1 36741943 5 - by peak with adj size 737926 737932 F344/NCrl LEW/Crl 7 1 38119654 5 - by peak with adj size 7 1 35342956 5 - by peak with adj size 2317048 rat Ginf1 Gastrointestinal inflammation QTL 1 8 3.52 0.005 10.2 41522 D8Rat164 cecum mucosa thickness (VT:0010234) enterocolitis severity score (CMO:0002138) granulomatous inflammation;intestinal inflammation Enterocolitis;inflammatory bowel disease 2316974 19526527 recessive 8 7378774 52378774 5 - by peak with adj size 8 5914098 50914098 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 7368076 52368076 5 - by peak with adj size 8 4705810 49705810 5 - by peak with adj size 2317050 rat Aia24 Adjuvant induced arthritis QTL 24 15 2.06 7.5 41636 D15Rat123 34222 D15Mgh8 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 15 63333669 84794402 1 - by flanking markers 15 58412001 80362100 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 15 59651151 81255430 1 - by flanking markers 15 52847908 73690657 1 - by flanking markers 2317051 rat Aia18 Adjuvant induced arthritis QTL 18 8 2.42 10.3 42244 D8Arb6 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 8 11490219 56490219 5 - by peak with adj size 8 10116155 55116155 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 11448251 56448251 5 - by peak with adj size 8 8736635 53736635 5 - by peak with adj size 2317052 rat Aia17 Adjuvant induced arthritis QTL 17 7 2.13 5.7 37374 D7Rat99 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 7 90956573 135956573 5 - by peak with adj size 7 87525274 132525274 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 7 91018361 136018361 5 - by peak with adj size 7 81737938 126737938 5 - by peak with adj size 2317053 rat Aia25 Adjuvant induced arthritis QTL 25 17 2.69 7.9 35585 D17Rat151 34120 D17Mgh5 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 17 51171794 65440692 1 - by flanking markers 17 59104944 71569891 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 17 53475276 63675975 1 - by flanking markers 17 50909196 60781426 1 - by flanking markers 2317054 rat Aia12 Adjuvant induced arthritis QTL 12 17 4.24 11.0 35585 D17Rat151 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 17 42940774 87940774 5 - by peak with adj size 17 49069974 94069974 5 - by peak with adj size 737926 737932 F344/NCrl LEW/Crl 17 41176057 86176057 5 - by peak with adj size 17 38281509 83281509 5 - by peak with adj size 2317055 rat Aia10 Adjuvant induced arthritis QTL 10 15 3.41 8.9 40516 D15Rat106 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 recessive 15 87444850 114627140 5 - by peak with adj size 15 83677810 109758846 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 15 84050550 111246239 5 - by peak with adj size 15 75788062 101769107 5 - by peak with adj size 2317056 rat Wbc3 White blood cell count QTL 3 5 2.51 0.01 36187 D5Rat30 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) decreased leukocyte cell number inflammatory bowel disease;leukopenia 2316974 19526527 recessive 5 115070246 160070246 5 - by peak with adj size 5 112840801 157840801 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 5 111278451 156278451 5 - by peak with adj size 5 105999803 150999803 5 - by peak with adj size 2317057 rat Aia27 Adjuvant induced arthritis QTL 27 20 2.83 13.7 41562 D20Rat46 37888 D20Rat34 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 20 5499214 29787701 1 - by flanking markers 20 3039759 37383914 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 20 3402111 27968216 1 - by flanking markers 20 2892597 26381954 1 - by flanking markers 2317058 rat Aia13 Adjuvant induced arthritis QTL 13 2 2.9 8.1 33620 D2Mit6 37664 D2Rat167 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 recessive 2 98037122 99636963 1 - by flanking markers 2 77630629 79118861 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 2 78321410 79969856 1 - by flanking markers 2 76539322 77991361 1 - by flanking markers 2317059 rat Aia15 Adjuvant induced arthritis QTL 15 7 2.46 7.4 36422 D7Rat26 34999 D7Rat44 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 7 24590450 69590450 4 - by one flank marker only 7 21202126 66202126 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 7 55072862 69399731 1 - by flanking markers 7 17004598 62004598 4 - by one flank marker only 2317060 rat Aia26 Adjuvant induced arthritis QTL 26 17 3.22 8.4 35585 D17Rat151 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 17 42940774 87940774 5 - by peak with adj size 17 49069974 94069974 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 17 41176057 86176057 5 - by peak with adj size 17 38281509 83281509 5 - by peak with adj size 2317577 rat Eae24 Experimental allergic encephalomyelitis QTL 24 4 37012 D4Rat25 60806 D4Wox7 36181 D4Rat26 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419);percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047);post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) CNS inflammation Experimental Autoimmune Encephalomyelitis 2317591;2317711 19675581 4 65802990 138066698 1 - by flanking markers 4 65821936 71729738 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 65987814 73372824 1 - by flanking markers 4 66993185 72752834 1 - by flanking markers 2317586 rat Eae25 Experimental allergic encephalomyelitis QTL 25 4 9.300000190734863 11009 D4Wox21 42705 D4Rat265 43816 D4Got64 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis duration (CMO:0001424);experimental autoimmune encephalomyelitis severity score (CMO:0001419);percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047);post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) CNS inflammation;weight loss Experimental Autoimmune Encephalomyelitis 2317591;2317711 19675581 4 144235277 148715224 1 - by flanking markers 4 78039509 82266081 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 79559380 84053053 1 - by flanking markers 4 78882817 83007655 1 - by flanking markers 2317587 rat Eae26 Experimental allergic encephalomyelitis QTL 26 4 40586 D4Rat231 10560 D4Mit12 36462 D4Rat36 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation;weight loss Experimental Autoimmune Encephalomyelitis 2317711;2317591 19675581 4 154593964 163844298 1 - by flanking markers 4 88462327 104416171 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 89777552 99067150 1 - by flanking markers 4 88656681 103194984 1 - by flanking markers 2317588 rat Eae27 Experimental allergic encephalomyelitis QTL 27 4 10560 D4Mit12 39990 D4Rat177 40014 D4Rat233 nervous system integrity trait (VT:0010566) percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047) CNS inflammation Experimental Autoimmune Encephalomyelitis 2317711;2317591 19675581 4 163844120 175325053 1 - by flanking markers 4 104415992 114074165 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 99066972 110635449 1 - by flanking markers 4 103194805 112478794 1 - by flanking markers 2317750 rat Glom26 Glomerulus QTL 26 15 4.3 38200 D15Rat54 41010 D15Rat96 41564 D15Rat80 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 15 19494318 76140870 1 - by flanking markers 15 14072029 71533203 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 15 15492360 72568189 1 - by flanking markers 15 12496141 65205939 1 - by flanking markers 2317752 rat Glom23 Glomerulus QTL 23 2 3.6 40892 D2Rat234 35340 D2Rat70 38054 D2Rat138 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 2 228015546 281850471 1 - by flanking markers 2 201223893 254933362 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 2 208594330 263179188 1 - by flanking markers 2 193452645 245889826 1 - by flanking markers 2317753 rat Glom24 Glomerulus QTL 24 5 3.1 35352 D5Rat33 35771 D5Rat22 35771 D5Rat22 kidney glomerulus integrity trait (VT:0010546) kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 5 105287339 145698175 1 - by flanking markers 5 102024381 143540180 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 5 101265591 141912026 1 - by flanking markers 5 97570330 136479578 1 - by flanking markers 2317754 rat Glom25 Glomerulus QTL 25 10 3.5 41478 D10Rat186 38514 D10Rat105 38514 D10Rat105 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 10 86167133 112200500 5 - by peak with adj size 10 86810917 110718848 5 - by peak with adj size intercross 1298093 1358112 LEW/NHsd WKY/NCrl 10 86566908 112626471 5 - by peak with adj size 10 82685200 107211142 5 - by peak with adj size 2317755 rat Glom22 Glomerulus QTL 22 1 3.8 36640 D1Rat14 36568 D1Rat4 39666 D1Rat246 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 1 12920275 36395486 1 - by flanking markers 1 1 11860328 2 - by one flank and peak markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 1 11314658 34993348 1 - by flanking markers 1 11481482 32355910 1 - by flanking markers 2317833 rat Alcrsp19 Alcohol response QTL 19 1 12.4 0.001 36432 D1Rat35 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 2317807;1334439 19500156;15608595 Alcrsp1 (sub_region) 1 109458992 154458992 5 - by peak with adj size 1 102248992 147248992 5 - by peak with adj size intercross 1578694 1578715 AT ANT 1 108417193 153417193 5 - by peak with adj size 1 100979852 145979852 5 - by peak with adj size 2317840 rat Alcrsp20 Alcohol response QTL 20 6 2.4000000953674316 0.63 37718 D6Rat90 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 intercross intercross 1578694 1578715 AT ANT 2317848 rat Alcrsp21 Alcohol response QTL 21 19 1.899999976158142 0.05 35376 D19Rat12 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 19 12034075 57034075 5 - by peak with adj size 19 4997213 49997213 5 - by peak with adj size intercross intercross 1578694 1578715 AT ANT 19 1044648 46044648 5 - by peak with adj size 19 3204777 48204777 5 - by peak with adj size 2317851 rat Alcrsp22 Alcohol response QTL 22 20 3.2 0.05 38324 D20Rat32 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 2317807 19500156 20 1 28385430 5 - by peak with adj size 20 1 27477794 5 - by peak with adj size intercoss 1578694 1578715 AT ANT 20 1 26305996 5 - by peak with adj size 20 1 27339237 5 - by peak with adj size 2317879 rat Alcrsp27 Alcohol response QTL 27 14 3.3 0.63 40342 D14Rat92 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 2317807 19500156 14 62674474 107674474 5 - by peak with adj size 14 62384564 107384564 5 - by peak with adj size intercross 1578694 1578715 AT ANT 14 61993178 106993178 5 - by peak with adj size 14 56631369 101631369 5 - by peak with adj size 2317880 rat Alcrsp25 Alcohol response QTL 25 20 2.3 37446 D20Rat54 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 20 19560735 57791882 5 - by peak with adj size 20 18303073 55268282 5 - by peak with adj size intercross 1578694 1578715 AT ANT 20 17827096 56205956 5 - by peak with adj size 20 17697550 54435887 5 - by peak with adj size 2317882 rat Alcrsp24 Alcohol response QTL 24 8 3.2 0.05 36039 D8Rat58 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 8 1 25960178 5 - by peak with adj size 8 1 25539735 5 - by peak with adj size intercross 1578694 1578715 AT ANT 8 1 25942267 5 - by peak with adj size 8 1 25902202 5 - by peak with adj size 2317883 rat Alcrsp26 Alcohol response QTL 26 3 1.8 0.63 36745 D3Rat1 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 3 157627942 183740530 5 - by peak with adj size 3 147516452 171063335 5 - by peak with adj size intercross 1578694 1578715 AT ANT 3 153918022 177699992 5 - by peak with adj size 3 145526770 169034231 5 - by peak with adj size 2317885 rat Alcrsp28 Alcohol response QTL 28 2 2.1 0.63 36574 D2Rat68 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 2 248320486 285068071 5 - by peak with adj size 2 222136025 258207540 5 - by peak with adj size intercross 1578694 1578715 AT ANT 2 229793522 266435125 5 - by peak with adj size 2 212828222 249053267 5 - by peak with adj size 2317886 rat Alcrsp23 Alcohol response QTL 23 2 2.4 0.63 42596 D2Rat339 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 intercross 1578694 1578715 AT ANT 2 96844330 141844330 5 - by peak with adj size 2324617 rat Coatc2 Coat color QTL 2 14 0.001 90.0 38932 D14Rat36 36287 D14Rat12 45176 D14Got40 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810) abnormal coat/hair pigmentation 2317982 20364790 recessive Coatc4 (interacts with) 14 32833464 61886417 1 - by flanking markers 14 33039698 41707592 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 14 33039912 61783215 1 - by flanking markers 14 30767025 39153750 1 - by flanking markers 2324619 rat Coatc4 Coat color QTL 4 17 0.001 18.0 35176 D17Rat2 38772 D17Rat102 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810);pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811) abnormal coat/hair pigmentation 2317982 20364790 Coatc2 (interacts with) 17 5553716 25980421 1 - by flanking markers 17 9988620 27118575 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 17 3336972 24030841 1 - by flanking markers 17 4299130 21293263 1 - by flanking markers 2324620 rat Coatc3 Coat color QTL 3 15 7.0 36313 D15Rat5 35611 D15Rat11 35120 D15Rat6 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810) abnormal coat/hair pigmentation 2317982 20364790 15 24970714 56554042 1 - by flanking markers 15 22452603 51526246 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 15 21021342 52831189 1 - by flanking markers 15 19856566 46187442 1 - by flanking markers 2324621 rat Coatc5 Coat color QTL 5 17 9.0 36225 D17Rat15 35687 D17Rat47 10349 D17Arb7 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation 2317982 20364790 17 33949701 79573336 1 - by flanking markers 17 37727971 85072478 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 17 32055882 77922655 1 - by flanking markers 17 31368391 73951021 1 - by flanking markers 2325725 rat Eae31 Experimental allergic encephalomyelitis QTL 31 1 39006 D1Rat193 35851 D1Rat68 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2324646;6892695 20072140;20072140 2899;1304950 Il4r;Il21r 1 201022827 212591221 1 - by flanking markers 1 183163129 193070197 1 - by flanking markers intercross 2298494 2306784 Kini:DA,PVG-G10 Kini:DA,PVG-G12 1 193968438 205603226 1 - by flanking markers 1 178810256 188377506 1 - by flanking markers 2325726 rat Eae30 Experimental allergic encephalomyelitis QTL 30 1 39316 D1Rat217 40922 D1Rat270 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2324646;6892695 20072140;20072140 1311983 Rgma 1 131506554 136616701 1 - by flanking markers 1 124308081 130290315 1 - by flanking markers intercross 2298494 2306784 Kini:DA,PVG-G10 Kini:DA,PVG-G12 1 130458716 135612014 1 - by flanking markers 1 123053310 128593844 1 - by flanking markers 2325727 rat Pia41 Pristane induced arthritis QTL 41 1 39006 D1Rat193 1629174 D1Got334 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) CNS inflammation;increased susceptibility to induced arthritis;joint swelling Experimental Arthritis;multiple sclerosis;rheumatoid arthritis 2324646;6892695 20072140;20072140 2899;1304950 Il4r;Il21r 1 201022827 204626168 1 - by flanking markers 1 183163129 185328208 1 - by flanking markers 2298494 2306784 Kini:DA,PVG-G10 Kini:DA,PVG-G12 1 193968438 197643128 1 - by flanking markers 1 178810256 180814005 1 - by flanking markers 2325836 rat Bp346 Blood pressure QTL 346 10 0.001 44781 D10Got112 2875 Igfbp4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185;6480214;7421500 18806617;22124177;23814039 2323022 Tom1l3 Bp258 (interacts with);Bp279 (interacts with);Bp310 (interacts with) 10 78816241 86759484 1 - by flanking markers 10 79857808 87834315 1 - by flanking markers 2325798 SS.LEW-(D10Got112-Igfbp4)/Ayd 10 78970279 86962563 1 - by flanking markers 10 76246085 84007272 1 - by flanking markers 2325838 rat Bp347 Blood pressure QTL 347 16 0.001 1358050 D16Chm48 1358041 D16Chm60 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185;7421500;11573640 18806617;23814039;27391979 1595469 Tasor Bp279 (interacts with);Bp310 (interacts with);Bp318 (interacts with) 16 2471921 3491557 1 - by flanking markers 16 2116303 3165043 1 - by flanking markers 2325801 2325803 SS.LEW-(D16Chm36-D16Mit2)/Ayd SS.LEW-(D16Rat112-D16Chm60)/Ayd 16 1 3525217 4 - by one flank marker only 16 1 3080679 4 - by one flank marker only 2325839 rat Bp348 Blood pressure QTL 348 18 0.001 1579149 D18Chm3 1579055 D18Chm52 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185 18806617 18 26454805 43276109 1 - by flanking markers 18 26435325 44551526 1 - by flanking markers 2301381 2301385 SS.LEW-(D18Chm41-D18Rat92)/Ayd SS.LEW-(D18Rat29-D18Rat55)/Ayd 18 26743404 43659626 1 - by flanking markers 18 25570985 70570985 4 - by one flank marker only 2325840 rat Bp345 Blood pressure QTL 345 3 0.001 10260 D3Rat52 728024 D3Chm57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185;7421500;9685142 18806617;23814039;25380161 Bp256 (interacts with);Bp310 (interacts with) 3 19410399 34290625 1 - by flanking markers 3 14051872 24716931 1 - by flanking markers 2325796 SS.LEW-(D3Rat52-D3Chm57)/Ayd 3 14090411 29084626 1 - by flanking markers 3 18311454 28441896 1 - by flanking markers 4145117 rat Mcs27 Mammary carcinoma susceptibility QTL 27 13 1.0E-4 41346 D13Rat123 37314 D13Rat101 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 4143380 20737482 Mcs26 (maps to same region) 13 53846466 58314767 1 - by flanking markers 13 44872181 49428577 1 - by flanking markers intercross 2293145 SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi 13 48776655 53264877 1 - by flanking markers 13 43437904 47841255 1 - by flanking markers 4145118 rat Mcs26 Mammary carcinoma susceptibility QTL 26 6 1.0E-4 40144 D6Rat119 42200 D6Arb3 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 4143380 20737482 Mcs27 (maps to same region) 6 120420333 147057860 1 - by flanking markers 6 111239053 138260635 1 - by flanking markers intercross 4145088 SS.BN-(D6Rat119-D6Arb3)/Mcwi 6 111134524 138065254 1 - by flanking markers 6 106752656 132339866 1 - by flanking markers 4145119 rat Mcs25 Mammary carcinoma susceptibility QTL 25 6 1.0E-4 39716 D6Rat149 35198 D6Rat11 mammary gland integrity trait (VT:0010552) ratio of deaths to total study population during a period of time (CMO:0001023) Drug-Related Side Effects and Adverse Reactions 4143380 20737482 6 6959479 124634525 1 - by flanking markers 6 7161389 115238799 1 - by flanking markers intercross 4145090 4145091 SS.BN-(D6Rat149-D6Got171)/Mcwi SS.BN-(D6Rat149-D6Arb3)/Mcwi 6 7009971 115379601 1 - by flanking markers 6 10894415 110548006 1 - by flanking markers 4889419 rat Cstrr2 Cold stress response QTL 2 1 0.05 38112 D1Rat171 60203 D1Got154 urine catecholamine amount (VT:0010502) absolute change in urine norepinephrine level (CMO:0001634) abnormal response of heart to induced stress;increased urine noradrenaline level autonomic nervous system disease;hypertension 4889147 21063213 Stresp24 (maps to same region) 1 172767534 175466596 1 - by flanking markers 1 158964262 161961786 1 - by flanking markers 4889411 SHRSP.WKY-(D1Smu13-D1Wox33)/Izm 1 166577232 169318847 1 - by flanking markers 1 155866514 158592016 1 - by flanking markers 4889428 rat Stresp24 Stress response QTL 24 1 0.05 38112 D1Rat171 11019 D1Wox33 heart pumping trait (VT:2000009) absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162) abnormal sensory capabilities/reflexes/nociception;increased circulating noradrenaline level autonomic nervous system disease;hypertension 4889147 21063213 Cstrr2 (maps to same region) 1 172767534 174300801 1 - by flanking markers 1 158964262 160755065 1 - by flanking markers 4889414 WKY.SHRSP-(D1Rat171-D1Wox33)/Izm 1 166577232 211577232 4 - by one flank marker only 1 155866514 200866514 4 - by one flank marker only 4889451 rat Eae29 Experimental allergic encephalomyelitis QTL 29 1 5.51 39234 D1Rat248 35685 D1Rat10 43193 D1Got11 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2317711;4888518 21041731 1303169 Il22ra2 1 7306802 86917075 1 - by flanking markers 1 6253932 25271177 1 - by flanking markers 4889450 DA.PVG.1AV1-(D1Rat248-D1Rat10)/Kini 1 5655772 85706974 1 - by flanking markers 1 5925877 24697545 1 - by flanking markers 4889492 rat Pancm2 Pancreatic morphology QTL 2 10 3.2 44840 D10Got156 pancreatic beta cell morphology trait (VT:0005217) ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814) decreased pancreatic beta cell mass type 2 diabetes mellitus 4889455 20878524 10 79903416 112200500 5 - by peak with adj size 10 81350126 110718848 5 - by peak with adj size intercross 737972 4889464 BN/Crl GK/Ox 10 80239190 112626471 5 - by peak with adj size 10 76748906 107211142 5 - by peak with adj size 4889494 rat Scort2 Serum corticosterone level QTL 2 1 4.2 1634688 D1Got308 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) decreased circulating corticosterone level type 2 diabetes mellitus 4889455 20878524 1 87808001 132808001 5 - by peak with adj size 1 80851478 125851478 5 - by peak with adj size intercross 737972 4889464 BN/Crl GK/Ox 1 86776571 131776571 5 - by peak with adj size 1 80592172 125592172 5 - by peak with adj size 4889511 rat Gluco61 Glucose level QTL 61 4 4.7 0.001 39194 D4Rat115 41888 D4Rat282 43767 D4Got15 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) decreased circulating insulin level;decreased pancreas weight;increased circulating glucose level Experimental Diabetes Mellitus 2326163 20530722 621465;1584719 Ica1;Ndufa4 Gluco32 (maps to same region) 4 34996009 38909359 1 - by flanking markers 4 34206019 38029988 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 4 35138860 39073276 1 - by flanking markers 4 37177950 40869000 1 - by flanking markers 4889521 rat Gluco62 Glucose level QTL 62 11 2.82 0.001 40158 D11Rat65 39356 D11Rat41 35955 D11Rat38 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating insulin level;decreased pancreas weight;increased circulating glucose level Experimental Diabetes Mellitus 2326163 20530722 11 64210638 90233310 1 - by flanking markers 11 56625258 67465962 2 - by one flank and peak markers 1357181 1357191 CDR/Ygl CDS/Ygl 11 60109842 87141948 1 - by flanking markers 11 55136729 82993457 1 - by flanking markers 4889606 rat Gluco63 Glucose level QTL 63 13 2.86 0.003 37554 D13Rat57 34124 D13Mgh6 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) decreased circulating insulin level;decreased pancreas weight;increased circulating glucose level Experimental Diabetes Mellitus 2326163 20530722 13 91468337 118718031 2 - by one flank and peak markers 13 84280242 111154910 2 - by one flank and peak markers 1357181 1357191 CDR/Ygl CDS/Ygl 13 86833393 114033958 2 - by one flank and peak markers 13 80753256 106807694 2 - by one flank and peak markers 4889610 rat Pancm3 Pancreatic morphology QTL 3 20 3.75 0.001 35657 D20Rat5 37792 D20Rat29 37652 D20Rat26 pancreas mass (VT:0010144) pancreas wet weight (CMO:0000626) increased pancreas weight Experimental Diabetes Mellitus 2326163 20530722 20 21025611 50747478 1 - by flanking markers 20 18411845 48055886 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 20 18872150 49108956 1 - by flanking markers 20 17617832 47606836 1 - by flanking markers 4889834 rat Pur24 Proteinuria QTL 24 2 5.8 0.014 34234 D2Mgh9 34461 D2Mgh12 10712 D2Mgh10 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 2 218191291 235592880 1 - by flanking markers 2 191378142 210636169 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 2 198704357 217498710 1 - by flanking markers 2 184114274 202447032 1 - by flanking markers 4889848 rat Pur25 Proteinuria QTL 25 6 14.0 0.003 36452 D6Rat25 40588 D6Rat165 34306 D6Mgh5 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 6 69405371 103458909 2 - by one flank and peak markers 6 58941174 93819252 2 - by one flank and peak markers 631572 631573 SBH/Ygl SBN/Ygl 6 59803065 94001333 2 - by one flank and peak markers 6 56728562 90198260 2 - by one flank and peak markers 4889852 rat Pur26 Proteinuria QTL 26 9 15.0 0.001 33999 D9Mit5 40510 D9Rat109 34088 D9Mgh2 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 9 89765913 106780702 1 - by flanking markers 9 75633467 100495220 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 9 90024661 107199079 1 - by flanking markers 9 77813894 101597663 1 - by flanking markers 4889857 rat Pur27 Proteinuria QTL 27 20 12.2 0.001 37594 D20Rat41 35657 D20Rat5 38324 D20Rat32 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 2231;3426;69418;628596 C2;Psmb8;Ubd;Tubb5 recessive 20 6118659 21025734 1 - by flanking markers 20 4740609 18411969 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 20 4039113 18872273 1 - by flanking markers 20 4606607 17617956 1 - by flanking markers 4889859 rat Pur28 Proteinuria QTL 28 11 19.5 0.001 36095 D11Rat7 34118 D11Mgh2 35955 D11Rat38 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 11 51082377 81545905 2 - by one flank and peak markers 11 46499941 77591279 2 - by one flank and peak markers 631572 631573 SBH/Ygl SBN/Ygl 11 47901049 78471527 2 - by one flank and peak markers 11 45459323 75190161 2 - by one flank and peak markers 4889861 rat Pur29 Proteinuria QTL 29 13 13.8 0.005 34351 D13Mgh4 37554 D13Rat57 37844 D13Rat85 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 13 47416073 91468484 1 - by flanking markers 13 38489801 84280390 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 13 42310744 86833540 1 - by flanking markers 13 37415584 80753406 1 - by flanking markers 4889870 rat Pur30 Proteinuria QTL 30 20 19.0 0.005 37632 D20Rat49 39998 D20Rat64 43144 D20Rat67 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 2231;3426;69418;628596 C2;Psmb8;Ubd;Tubb5 recessive 20 10844023 32781021 1 - by flanking markers 20 8286533 28734502 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 20 8654341 30991290 1 - by flanking markers 20 8042410 29322208 1 - by flanking markers 4889891 rat Eae32 Experimental allergic encephalomyelitis QTL 32 17 4.8 2.0E-4 34827 D17Rat12 45464 D17Got49 45469 D17Got45 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 4889889;629629 20856809;12517974 1306984 Btn1a1 17 29605177 39973813 1 - by flanking markers 17 33277173 42659723 1 - by flanking markers 2298494 Kini:DA,PVG-G10 17 27690959 38110914 1 - by flanking markers 17 27027949 36146731 1 - by flanking markers 4889894 rat Eae33 Experimental allergic encephalomyelitis QTL 33 17 5.2 1.0E-4 34120 D17Mgh5 38092 D17Rat95 60143 D17Got120 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 4889889;629629 20856809;12517974 3831 Zeb1 17 51171698 92351300 1 - by flanking markers 17 59104847 66993271 1 - by flanking markers 2298494 4889890 Kini:DA,PVG-G10 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini 17 53475180 90690466 1 - by flanking markers 17 50909099 86022412 1 - by flanking markers 4889919 rat Bss86 Bone structure and strength QTL 86 1 4.1 36610 D1Rat20 10442 D1Wox16 tibia area (VT:1000281) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone strength osteoporosis 4889918 20699128 1 55091281 84871565 1 - by flanking markers 1 48777689 81947972 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 53851348 83657083 1 - by flanking markers 1 53895117 82174945 1 - by flanking markers 4889929 rat Bss87 Bone structure and strength QTL 87 1 6.7 36610 D1Rat20 10442 D1Wox16 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) decreased bone strength osteoporosis 4889918 20699128 1 55091281 84871565 1 - by flanking markers 1 48777689 81947972 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 53851348 83657083 1 - by flanking markers 1 53895117 82174945 1 - by flanking markers 4889933 rat Bss88 Bone structure and strength QTL 88 6 3.8 34184 D6Mgh11 33897 D3Mit19 tibia size trait (VT:0100001) tibia total bone volume (CMO:0001724) decreased bone strength osteoporosis 4889918 20699128 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4889938 rat Bss89 Bone structure and strength QTL 89 8 3.8 33973 D8Mit2 34310 D8Mgh4 tibia size trait (VT:0100001) tibia cortical bone volume (CMO:0001725) decreased bone strength osteoporosis 4889918 20699128 8 52685897 88595536 1 - by flanking markers 8 53049279 86628010 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 54065044 89058369 1 - by flanking markers 8 50095249 82460899 1 - by flanking markers 4889943 rat Bss90 Bone structure and strength QTL 90 9 4.1 34088 D9Mgh2 36908 D9Rat4 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) decreased bone strength osteoporosis 4889918 20699128 9 92471883 98282881 1 - by flanking markers 9 84432884 90697021 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 9 92741297 98606834 1 - by flanking markers 9 86369631 92058970 1 - by flanking markers 4889948 rat Bss91 Bone structure and strength QTL 91 10 4.0 34274 D10Mgh5 34485 D10Mgh4 tibia area (VT:1000281) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone strength osteoporosis 4889918 20699128 10 85302342 95372987 1 - by flanking markers 10 86316831 96799937 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 85513822 95638337 1 - by flanking markers 10 82564856 92369470 1 - by flanking markers 4889951 rat Bss92 Bone structure and strength QTL 92 14 3.9 10773 D14Mit10 35897 D14Rat22 tibia area (VT:1000281) tibia-fibula cortical bone total cross-sectional area (CMO:0001721) decreased bone strength osteoporosis 4889918 20699128 14 81093112 106705037 1 - by flanking markers 14 87960277 102509397 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 87458772 106641756 1 - by flanking markers 14 82057471 95876975 1 - by flanking markers 4889955 rat Bss93 Bone structure and strength QTL 93 17 4.4 34827 D17Rat12 10348 D17Mit4 tibia size trait (VT:0100001) tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727) decreased bone strength osteoporosis 4889918 20699128 17 29605177 65757501 1 - by flanking markers 17 33277173 71214857 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 17 27690959 63994435 1 - by flanking markers 17 27027949 60463643 1 - by flanking markers 4889962 rat Bss94 Bone structure and strength QTL 94 1 3.8 33660 D1Mit9 10442 D1Wox16 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) decreased bone strength osteoporosis 4889918 20699128 1 50204369 84871565 1 - by flanking markers 1 43840481 81947972 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 49547328 83657083 1 - by flanking markers 1 49361465 82174945 1 - by flanking markers 4889966 rat Bss95 Bone structure and strength QTL 95 3 4.4 33782 D3Mit10 36047 D3Rat46 tibia area (VT:1000281) tibia-fibula cross-sectional area (CMO:0001718) decreased bone strength osteoporosis 4889918 20699128 3 1 42991394 4 - by one flank marker only 3 1 33871290 4 - by one flank marker only 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 1 37891710 4 - by one flank marker only 3 1 36847613 4 - by one flank marker only 4889969 rat Bss96 Bone structure and strength QTL 96 4 4.9 33656 D4Mit9 11015 D4Mit24 tibia size trait (VT:0100001) tibia cortical bone volume (CMO:0001725) decreased bone strength osteoporosis 4889918 20699128 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 4889972 rat Bss97 Bone structure and strength QTL 97 4 5.6 33656 D4Mit9 11015 D4Mit24 tibia size trait (VT:0100001) tibia total bone volume (CMO:0001724) decreased bone strength osteoporosis 4889918 20699128 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 4889975 rat Bmd81 Bone mineral density QTL 81 3 4.3 37588 D3Rat189 11260 D3Mit8 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 4889918 20699128 3 44863125 58322647 1 - by flanking markers 3 35797577 47588420 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 39773247 51687917 1 - by flanking markers 3 38710365 50302886 1 - by flanking markers 5135224 rat Leukc1 Leukocyte quantity QTL 1 19 36709 D19Rat8 41262 D19Rat57 eosinophil quantity (VT:0002602) blood eosinophil count (CMO:0000033) increased eosinophil cell number Eosinophilia 5135221 16151696 1312024;1582810 Irf8;Zfpm1 recessive 19 59631471 70892142 1 - by flanking markers 19 12235101 57235101 4 - by one flank marker only backcross 1302670 1302728 ACI/NSlc MES/Slc 19 48830712 60220581 1 - by flanking markers 19 44340214 55283277 1 - by flanking markers 5135226 rat Leukc2 Leukocyte quantity QTL 2 2 41358 D2Rat217 35162 D2Rat38 eosinophil quantity (VT:0002602) blood eosinophil count (CMO:0000033) increased eosinophil cell number Eosinophilia 5135221 16151696 additive 2 141390480 175354471 1 - by flanking markers 2 121545310 155102371 1 - by flanking markers 1302670 1302728 ACI/NSlc MES/Slc 2 121750419 155965721 1 - by flanking markers 2 118111229 149559726 1 - by flanking markers 5508828 rat Leukc3 Leukocyte quantity QTL 3 1 37754 D1Rat123 37902 D1Rat169 eosinophil quantity (VT:0002602) blood eosinophil count (CMO:0000033) increased eosinophil cell number Eosinophilia 5135221;5135222 16151696;17090969 1 245518822 251652933 1 - by flanking markers 1 223729174 229876997 1 - by flanking markers 1302670 1302728 ACI/NSlc MES/Slc 1 238220189 244401301 1 - by flanking markers 1 218108584 224054420 1 - by flanking markers 5684888 rat Pia42 Pristane induced arthritis QTL 42 12 11051 D12Mit2 38410 D12Rat53 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 1302414;1600250 17329308 12 24662983 50380790 1 - by flanking markers 12 20932559 43863270 1 - by flanking markers 1643007 DA.ACI-(D12Wox12-D12Rat53)/Arb 12 22650702 48598906 1 - by flanking markers 12 19610870 42828880 1 - by flanking markers 5684946 rat Bss98 Bone structure and strength QTL 98 15 3.9 0.0026 39940 D15Rat109 33614 D15Mit2 33614 D15Mit2 tibia strength trait (VT:1000284) tibia ultimate force (CMO:0001734) osteopetrosis 5684953 21818327 15 1094146 19829680 1 - by flanking markers 15 1007318 16365960 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 15 1105890 15828368 1 - by flanking markers 15 1058250 14481294 1 - by flanking markers 5684963 rat Bss99 Bone structure and strength QTL 99 6 3.1 34184 D6Mgh11 33897 D3Mit19 tibia area (VT:1000281) tibia area measurement (CMO:0001382) osteopetrosis 5684953 21818327 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5684973 rat Bss100 Bone structure and strength QTL 100 8 4.7 33973 D8Mit2 34310 D8Mgh4 33973 D8Mit2 tibia area (VT:1000281) tibia area measurement (CMO:0001382) osteoporosis 5684953 21818327 8 52685897 88595536 1 - by flanking markers 8 53049279 86628010 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 54065044 89058369 1 - by flanking markers 8 50095249 82460899 1 - by flanking markers 5684990 rat Bmd82 Bone mineral density QTL 82 2 2.8 11156 D2Mit24 34383 D2Mgh5 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 2 84360871 126162742 1 - by flanking markers 2 59700886 106523545 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 2 60325352 106432915 1 - by flanking markers 2 59324377 103795077 1 - by flanking markers 5684992 rat Bmd83 Bone mineral density QTL 82 6 4.8 34184 D6Mgh11 33897 D3Mit19 33897 D3Mit19 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5684993 rat Bmd84 Bone mineral density QTL 84 8 4.1 33887 D8Mit3 33973 D8Mit2 33973 D8Mit2 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 8 45061464 52686094 1 - by flanking markers 8 45291674 53049477 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 46588437 54065241 1 - by flanking markers 8 42692684 50095447 1 - by flanking markers 5684996 rat Bmd85 Bone mineral density QTL 85 2 4.7 0.024 11156 D2Mit24 34383 D2Mgh5 34383 D2Mgh5 tibia mineral mass (VT:1000283) bone mineral density (CMO:0001226) osteoporosis 5684953 21818327 2 84360871 126162742 1 - by flanking markers 2 59700886 106523545 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 2 60325352 106432915 1 - by flanking markers 2 59324377 103795077 1 - by flanking markers 5684998 rat Bss101 Bone structure and strength QTL 101 1 3.6 35467 D1Rat7 33660 D1Mit9 tibia strength trait (VT:1000284) tibia ultimate force (CMO:0001734) osteoporosis 5684953 21818327 1 17683508 50204515 1 - by flanking markers 1 15999377 43840628 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 16143143 49547474 1 - by flanking markers 1 15431621 49361612 1 - by flanking markers 5684999 rat Bss102 Bone structure and strength QTL 102 1 5.5 7.2E-7 35467 D1Rat7 33660 D1Mit9 34662 D1Mgh2 tibia strength trait (VT:1000284) tibia stiffness (CMO:0001735) osteoporosis 5684953 21818327 1 17683508 50204515 1 - by flanking markers 1 15999377 43840628 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 16143143 49547474 1 - by flanking markers 1 15431621 49361612 1 - by flanking markers 5685002 rat Bss103 Bone structure and strength QTL 103 15 2.8 33614 D15Mit2 62030 Myh7 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) osteoporosis 5684953 21818327 15 19829554 37544317 1 - by flanking markers 15 16365832 33094595 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 15 15828242 33657761 1 - by flanking markers 15 14481165 28469888 1 - by flanking markers 5685004 rat Bss104 Bone structure and strength QTL 104 X 3.9 34825 DXRat20 39724 DXRat103 34825 DXRat20 tibia area (VT:1000281) tibia area measurement (CMO:0001382) osteoporosis 5684953 21818327 X 121580137 134700747 1 - by flanking markers X 10563466 134157626 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe X 121442246 134627946 1 - by flanking markers X 113805422 126975220 1 - by flanking markers 5685009 rat Bmd86 Bone mineral density QTL 86 4 3.7 33656 D4Mit9 11015 D4Mit24 tibia mineral mass (VT:1000283) bone mineral density (CMO:0001226) osteoporosis 5684953 21818327 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 5685012 rat Bmd87 Bone mineral density QTL 87 4 5.1 33656 D4Mit9 11015 D4Mit24 33656 D4Mit9 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 5686842 rat Rf59 Renal function QTL 59 3 43714 D3Got102 60365 D3Got121 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level Albuminuria 5684423 21127141 Albq5_m (maps to syntenic region) 3 153428179 160798463 1 - by flanking markers 3 141890118 149038578 1 - by flanking markers 5686832 ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi 3 147072047 154807958 1 - by flanking markers 3 140069424 146976080 1 - by flanking markers 6478680 rat Anxrr29 Anxiety related response QTL 29 4 9.2E-4 14.0 34493 D4Mgh27 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 4 168999347 213999347 5 - by peak with adj size 4 106808891 151808891 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478684 rat Anxrr30 Anxiety related response QTL 30 4 8.7E-4 14.0 35721 D4Rat76 defecation behavior trait (VT:0010462) defecation rate (CMO:0000998) increased anxiety-related response anxiety disorder 6218999 21516450 4 128465092 173465092 5 - by peak with adj size 4 62386644 107386644 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 63812687 108812687 5 - by peak with adj size 4 62753847 107753847 5 - by peak with adj size 6478686 rat Anxrr31 Anxiety related response QTL 31 4 0.00998 9.0 38912 D4Rat131 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 additive intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478693 rat Anxrr32 Anxiety related response QTL 32 4 9.2E-4 14.0 34338 D4Mgh11 locomotor behavior trait (VT:0001392) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478700 rat Anxrr33 Anxiety related response QTL 33 4 0.00896 10.0 34338 D4Mgh11 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 dominant 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478718 rat Anxrr34 Anxiety related response QTL 34 4 0.00896 10.0 34338 D4Mgh11 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478720 rat Alc23 Alcohol consumption QTL 23 4 0.00509 11.0 40536 D4Rat206 drinking behavior trait (VT:0001422) ethanol drink intake rate to body weight ratio (CMO:0001616) increased alcohol consumption alcohol use disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478724 rat Anxrr35 Anxiety related response QTL 35 4 0.00449 41102 D4Rat151 defecation behavior trait (VT:0010462) defecation measurement (CMO:0000997) increased anxiety-related response anxiety disorder 6218999 21516450 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 6478728 rat Anxrr36 Anxiety related response QTL 36 4 0.01061 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 dominant intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478733 rat Anxrr37 Anxiety related response QTL 37 4 9.5E-4 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478737 rat Anxrr38 Anxiety related response QTL 38 4 0.00159 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478740 rat Anxrr39 Anxiety related response QTL 39 4 0.07528 34493 D4Mgh27 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 4 168999347 213999347 5 - by peak with adj size 4 106808891 151808891 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478743 rat Anxrr40 Anxiety related response QTL 40 4 0.83076 35721 D4Rat76 defecation behavior trait (VT:0010462) defecation rate (CMO:0000998) increased anxiety-related response anxiety disorder 6218999 21516450 4 128465092 173465092 5 - by peak with adj size 4 62386644 107386644 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 63812687 108812687 5 - by peak with adj size 4 62753847 107753847 5 - by peak with adj size 6478745 rat Anxrr41 Anxiety related response QTL 41 4 0.04995 38912 D4Rat131 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478748 rat Anxrr42 Anxiety related response QTL 42 4 0.28008 34338 D4Mgh11 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478754 rat Anxrr43 Anxiety related response QTL 43 4 0.14035 34338 D4Mgh11 locomotor behavior trait (VT:0001392) distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478757 rat Anxrr44 Anxiety related response QTL 44 4 0.01087 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478760 rat Anxrr45 Anxiety related response QTL 45 4 0.06717 34106 D4Mgh6 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 dominant 4 175184431 220184431 5 - by peak with adj size 4 113136999 158136999 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 110702761 155702761 5 - by peak with adj size 4 110870972 155870972 5 - by peak with adj size 6478763 rat Anxrr46 Anxiety related response QTL 46 4 0.07428 34106 D4Mgh6 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 175184431 220184431 5 - by peak with adj size 4 113136999 158136999 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 110702761 155702761 5 - by peak with adj size 4 110870972 155870972 5 - by peak with adj size 6478766 rat Anxrr47 Anxiety related response QTL 47 4 0.09637 41102 D4Rat151 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 6478769 rat Anxrr48 Anxiety related response QTL 48 4 0.02514 41102 D4Rat151 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 6478772 rat Anxrr49 Anxiety related response QTL 49 4 0.15488 35721 D4Rat76 defecation behavior trait (VT:0010462) defecation rate (CMO:0000998) increased anxiety-related response anxiety disorder 6218999 21516450 4 128465092 173465092 5 - by peak with adj size 4 62386644 107386644 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 63812687 108812687 5 - by peak with adj size 4 62753847 107753847 5 - by peak with adj size 6478775 rat Anxrr50 Anxiety related response QTL 50 4 0.66021 38912 D4Rat131 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 inducing agent: subcutaneous injection of estradiol benzoate (10ug/0.1ml) and progesterone (5mg/kg) in a injection volume of 1mg/kg;intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478778 rat Anxrr51 Anxiety related response QTL 51 4 0.25384 35088 D4Rat59 locomotor behavior trait (VT:0001392) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) increased anxiety-related response anxiety disorder 6218999 21516450 4 186880256 231880256 5 - by peak with adj size 4 127547983 172547983 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 123587009 168587009 5 - by peak with adj size 4 124778595 169778595 5 - by peak with adj size 6478782 rat Anxrr52 Anxiety related response QTL 52 4 0.02091 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478785 rat Anxrr53 Anxiety related response QTL 53 4 0.01397 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6480225 rat Gdil1 Gastrointestinal dilation QTL 1 2 42121 D2Arb7 35643 D2Rat21 33739 D2Mit5 enteric ganglion morphology trait (VT:0001045) length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836) aganglionic megacolon Hirschsprung's disease;Total Intestinal Aganglionosis;Waardenburg Syndrome Type 4 6480215;6480217;10402048 22132166;21915282;25790447 2677;1305942 Gdnf;Rai14 2 76649726 95410202 1 - by flanking markers 2 57161998 75806439 1 - by flanking markers intercross 6480218 6480223 AR-Ednrbsl/Hkv F344.AR-Ednrbsl/Hkv 2 58344100 75687607 1 - by flanking markers 2 56660879 74786777 1 - by flanking markers 6480773 rat Gluco64 Glucose level QTL 64 1 5.09 34244 D1Mgh10 43384 D1Got189 38854 D1Rat168 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance glucose intolerance 2303512;6893578;9587420 22947656;25236446 1311779 Tpcn2 1 223910550 225482294 1 - by flanking markers 1 204280278 205897680 1 - by flanking markers 2314009 NMcwi:HS 1 217054291 218614387 1 - by flanking markers 1 199050459 200611765 1 - by flanking markers 6480777 rat Insul17 Insulin level QTL 17 1 3.86 36239 D1Rat111 33878 D1Mit27 38954 D1Rat181 blood insulin amount (VT:0001560) blood insulin level area under curve (AUC) (CMO:0000351) increased circulating insulin level hyperinsulinism;type 2 diabetes mellitus 2303512;6893578 22947656 1 222009015 223075141 1 - by flanking markers 1 202350579 203303100 1 - by flanking markers 2314009 NMcwi:HS 1 215097781 216213510 1 - by flanking markers 1 197260913 198211706 1 - by flanking markers 6480780 rat Insul18 Insulin level QTL 18 1 4.11 38326 D1Rat129 43384 D1Got189 40534 D1Rat291 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level hyperinsulinism;type 2 diabetes mellitus 2303512;6893578;9587420 22947656;25236446 1311779 Tpcn2 1 218337839 225482294 1 - by flanking markers 1 198853034 205897680 1 - by flanking markers 2314009 NMcwi:HS 1 206950905 218614387 2 - by one flank and peak markers 1 189607473 200611765 2 - by one flank and peak markers 6480783 rat Insul19 Insulin level QTL 19 1 4.33 38326 D1Rat129 43384 D1Got189 34244 D1Mgh10 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level hyperinsulinism;type 2 diabetes mellitus 2303512;6893578;9587420 22947656;25236446 1311779 Tpcn2 1 218337839 225482294 1 - by flanking markers 1 198853034 205897680 1 - by flanking markers 2314009 NMcwi:HS 1 215494321 218614387 2 - by one flank and peak markers 1 197489281 200611765 2 - by one flank and peak markers 6480786 rat Bw97 Body weight QTL 97 1 5.03 34009 D1Mit34 41610 D1Rat300 41392 D1Rat302 body mass (VT:0001259) body weight (CMO:0000012) Weight Gain 2303512;6893578 22947656 1 252776360 255263602 1 - by flanking markers 1 230963695 233551254 1 - by flanking markers 2314009 NMcwi:HS 1 245529606 248013094 1 - by flanking markers 1 225126575 227604520 1 - by flanking markers 6893332 rat Cm74 Cardiac mass QTL 74 6 0.4 0.64 34126 D6Mgh4 33977 D6Mit4 34306 D6Mgh5 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 6 70194178 117391806 1 - by flanking markers 6 59946874 108503674 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 6 60606431 108154445 1 - by flanking markers 6 57730540 104085867 1 - by flanking markers 6893336 rat Cm75 Cardiac mass QTL 75 10 0.1 0.87 34445 D10Mgh6 34128 D10Mgh1 3177 Ngfr heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 10 63366082 103048942 2 - by one flank and peak markers 10 67677924 100865886 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 64648175 102149713 2 - by one flank and peak markers 10 61345276 99703528 2 - by one flank and peak markers 6893338 rat Cm76 Cardiac mass QTL 76 13 0.0 0.99 11375 D13Arb8 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 13 34129640 79129640 5 - by peak with adj size 13 25198204 70198204 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 13 29076934 74076934 5 - by peak with adj size 13 23692969 68692969 5 - by peak with adj size 6893340 rat Cm77 Cardiac mass QTL 77 6 0.26 0.57 33993 D6Mit2 33828 D6Mit9 33977 D6Mit4 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 6 46021394 94275468 1 - by flanking markers 6 34039461 84287190 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 6 36260288 84763275 1 - by flanking markers 6 33309549 81132889 1 - by flanking markers 6893342 rat Cm78 Cardiac mass QTL 78 10 0.1 0.88 34318 D10Mgh10 35563 D10Rat21 34445 D10Mgh6 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 10 35954931 82495564 1 - by flanking markers 10 36254741 83528010 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 10 36185929 82675365 1 - by flanking markers 10 42876766 79813922 2 - by one flank and peak markers 6893344 rat Cm79 Cardiac mass QTL 79 13 1.5 0.04 35925 D13Rat41 11115 D13Mgh7 11375 D13Arb8 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 13 54128085 72173144 1 - by flanking markers 13 45161605 64281346 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 13 49058507 67207219 1 - by flanking markers 13 43720770 62022792 1 - by flanking markers 6893347 rat Bw98 Body weight QTL 98 1 0.2 0.53 621323 Phox2a body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 1 150585707 195585707 5 - by peak with adj size 1 136792830 181792830 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 1 144395993 189395993 5 - by peak with adj size 1 133680936 178680936 5 - by peak with adj size 6893350 rat Bw99 Body weight QTL 99 1 0.87 0.16 10792 D10Wox10 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 16898761 61898761 5 - by peak with adj size 10 17185640 62185640 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 17121542 62121542 5 - by peak with adj size 10 15906665 60906665 5 - by peak with adj size 6893352 rat Bw100 Body weight QTL 100 1 0.33 0.6 10792 D10Wox10 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 16898761 61898761 5 - by peak with adj size 10 17185640 62185640 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 17121542 62121542 5 - by peak with adj size 10 15906665 60906665 5 - by peak with adj size 6893355 rat Bw101 Body weight QTL 101 3 0.4 0.38 34347 D3Mgh16 33862 D3Mit9 34347 D3Mgh16 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 3 11361699 39536215 1 - by flanking markers 3 6373335 26674263 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000748 34394365 1 - by flanking markers 3 10778704 30357018 1 - by flanking markers 6893357 rat Bw102 Body weight QTL 102 10 0.5 0.36 3177 Ngfr 34128 D10Mgh1 2493 Ace body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 83198396 104688792 2 - by one flank and peak markers 10 84262804 106479988 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 83389828 104994768 2 - by one flank and peak markers 10 80515287 101325465 2 - by one flank and peak markers 6893359 rat Bw103 Body weight QTL 103 18 1.2 0.12 34290 D18Mgh4 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 18 56512589 87229863 5 - by peak with adj size 18 57085070 87265094 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 18 57448678 88201929 5 - by peak with adj size 6893361 rat Bw104 Body weight QTL 104 1 0.59 0.27 621323 Phox2a body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 1 150585707 195585707 5 - by peak with adj size 1 136792830 181792830 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 1 144395993 189395993 5 - by peak with adj size 1 133680936 178680936 5 - by peak with adj size 6893363 rat Bw105 Body weight QTL 105 3 2.6 0.0036 34347 D3Mgh16 33862 D3Mit9 34347 D3Mgh16 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 3 11361699 39536215 1 - by flanking markers 3 6373335 26674263 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 3 6000748 34394365 1 - by flanking markers 3 10778704 30357018 1 - by flanking markers 6893366 rat Bw106 Body weight QTL 106 10 0.3 0.47 36624 D10Rat13 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 73201303 112200500 5 - by peak with adj size 10 74652410 110718848 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 10 73467158 112626471 5 - by peak with adj size 10 70199100 107211142 5 - by peak with adj size 6893368 rat Bw107 Body weight QTL 107 18 0.3 0.5 34290 D18Mgh4 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 18 56512589 87229863 5 - by peak with adj size 18 57085070 87265094 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 18 57448678 88201929 5 - by peak with adj size 6893678 rat Bw108 Body weight QTL 108 4 2.6 0.006 13.9 38728 D4Rat122 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 recessive 4 42237617 87237617 5 - by peak with adj size 4 42249950 87249950 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 4 42415777 87415777 5 - by peak with adj size 4 43457976 88457976 5 - by peak with adj size 6893681 rat Bw109 Body weight QTL 109 12 2.3 0.004 13.3 39814 D12Rat57 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 recessive 12 1 23736622 5 - by peak with adj size 12 1 25938641 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 12 1 23758197 5 - by peak with adj size 12 1 23297788 5 - by peak with adj size 6893683 rat Bw110 Body weight QTL 110 18 2.7 0.002 13.1 34182 D18Mgh3 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 additive 18 44165133 87229863 5 - by peak with adj size 18 46513375 87265094 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 18 45002194 88201929 5 - by peak with adj size 18 43345022 83828827 5 - by peak with adj size 6893685 rat Bw111 Body weight QTL 111 20 2.7 0.004 12.2 37872 D20Rat31 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 recessive 20 1 35472592 5 - by peak with adj size 20 1 32910115 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 20 1 33300419 5 - by peak with adj size 20 1 32578807 5 - by peak with adj size 6903292 rat Stl28 Serum triglyceride level QTL 28 5 2.6 0.0073 66655 D5Mco21 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 1299960 14709677 5 34199087 79199087 5 - by peak with adj size 5 30606308 75606308 5 - by peak with adj size 60999 1302795 LEW HTG 5 29641661 74641661 5 - by peak with adj size 5 28515489 73515489 5 - by peak with adj size 6903294 rat Stl30 Serum triglyceride level QTL 30 16 2.6 0.0013 66392 D16Mco7 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia;Metabolic Syndrome 1299960 14709677 16 28056288 73056288 5 - by peak with adj size 16 28455247 73455247 5 - by peak with adj size 60999 1302795 LEW HTG 16 28340315 73340315 5 - by peak with adj size 16 25152793 70152793 5 - by peak with adj size 6903300 rat Scl33 Serum cholesterol QTL 33 8 2.0 0.0125 37072 D8Rat59 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 8 92612869 132457389 5 - by peak with adj size 8 89742772 129041809 5 - by peak with adj size 60999 1302795 LEW HTG 6903303 rat Scl34 Serum cholesterol QTL 34 1 2.5 0.0033 36592 D1Rat64 37754 D1Rat123 37732 D1Rat208 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 1 204172176 245519018 1 - by flanking markers 1 184857716 223729371 1 - by flanking markers 60999 1302795 LEW HTG 1 197187728 238220385 1 - by flanking markers 1 180359209 218108781 1 - by flanking markers 6903306 rat Scl35 Serum cholesterol QTL 35 5 2.6 0.0073 66655 D5Mco21 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 5 34199087 79199087 5 - by peak with adj size 5 30606308 75606308 5 - by peak with adj size 60999 1302795 LEW HTG 5 29641661 74641661 5 - by peak with adj size 5 28515489 73515489 5 - by peak with adj size 6903308 rat Scl36 Serum cholesterol QTL 36 1 2.0 0.0125 38202 D1Rat229 38792 D1Rat137 35106 D1Rat335 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 1 40688397 95326185 2 - by one flank and peak markers 1 53013200 90306478 2 - by one flank and peak markers 60999 1302795 LEW HTG 1 50522714 94225616 1 - by flanking markers 1 53863041 90532583 2 - by one flank and peak markers 6903312 rat Bw112 Body weight QTL 112 2 3.2 0.0013 34234 D2Mgh9 34005 D2Mit8 36213 D2Rat40 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 2 169047413 218191291 1 - by flanking markers 2 148790758 191378142 1 - by flanking markers 60999 1302795 LEW HTG 2 149614623 198704357 1 - by flanking markers 2 143657569 184114274 1 - by flanking markers 6903316 rat Bw113 Body weight QTL 113 5 2.0 0.0103 41424 D5Rat156 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 5 95828682 140828682 5 - by peak with adj size 5 93245548 138245548 5 - by peak with adj size 60999 1302795 LEW HTG 5 91884213 136884213 5 - by peak with adj size 5 87765973 132765973 5 - by peak with adj size 6903319 rat Bw114 Body weight QTL 114 16 2.7 0.0037 35005 D16Rat6 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 16 136462 45136462 5 - by peak with adj size 16 172013 45172013 5 - by peak with adj size 60999 1302795 LEW HTG 16 244593 45244593 5 - by peak with adj size 16 1 43534949 5 - by peak with adj size 6903345 rat Bp349 Blood pressure QTL 349 18 3.9 33884 D18Mit8 36914 D18Rat18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 47464114 61176840 1 - by flanking markers 18 48759666 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 48249048 61985648 1 - by flanking markers 18 46718935 59796478 1 - by flanking markers 6903347 rat Bp350 Blood pressure QTL 350 18 4.4 33884 D18Mit8 10689 D18Mit5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 32348275 61176840 1 - by flanking markers 18 32458940 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 32670473 61985648 1 - by flanking markers 18 31359530 59796478 1 - by flanking markers 6903349 rat Bp351 Blood pressure QTL 351 18 3.5 33884 D18Mit8 36914 D18Rat18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp352 (maps to same region);Bp54 (sub_region) 18 47464114 61176840 1 - by flanking markers 18 48759666 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 48249048 61985648 1 - by flanking markers 18 46718935 59796478 1 - by flanking markers 6903351 rat Bp352 Blood pressure QTL 352 18 3.3 33884 D18Mit8 36914 D18Rat18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp351 (maps to same region);Bp54 (sub_region) 18 47464114 61176840 1 - by flanking markers 18 48759666 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 48249048 61985648 1 - by flanking markers 18 46718935 59796478 1 - by flanking markers 6903353 rat Bp353 Blood pressure QTL 353 18 2.8 33884 D18Mit8 34340 D18Mgh7 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure;salt-sensitive hypertension hypertension 69700;7327193 11015589;24023717 2004 A2m Bp54 (sub_region) 18 61176840 87229863 4 - by one flank marker only 18 62228896 87265094 4 - by one flank marker only 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 22604764 61985648 1 - by flanking markers 18 59796478 83828827 4 - by one flank marker only 6903356 rat Bp354 Blood pressure QTL 354 18 4.6 33884 D18Mit8 34092 D18Mgh8 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 61176840 87229863 4 - by one flank marker only 18 15852579 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 61985648 88201929 4 - by one flank marker only 18 59796478 83828827 4 - by one flank marker only 6903359 rat Bp355 Blood pressure QTL 355 18 3.6 33884 D18Mit8 11461 D18Mit1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 15314271 61176840 1 - by flanking markers 18 62228896 80277631 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 15539671 61985648 1 - by flanking markers 18 11944544 59796478 1 - by flanking markers 6903937 rat Bp356 Blood pressure QTL 356 9 0.001 2302905 D9Mco72 6903888 D9Mco105 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial diastolic blood pressure;decreased systemic arterial systolic blood pressure Hypotension 6903249 21814219 Bp333 (sub_region) 9 52352690 97352690 4 - by one flank marker only 9 44842118 89842118 4 - by one flank marker only 6903925 SS.SHR-(D9Mco72-D9Mco105)/Mco 9 52686874 57216771 1 - by flanking markers 9 47902208 52283252 1 - by flanking markers 6903941 rat Pur31 Proteinuria QTL 31 9 0.036 36924 D9Rat7 37724 D9Rat84 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) decreased urine protein level proteinuria 6903249 21814219 Bp334 (sub_region) 9 83453664 91313982 1 - by flanking markers 9 77172934 83316504 1 - by flanking markers 6903936 SS.SHR-(D9Rat7-D9Rat84)/Mco 9 46579769 91579769 4 - by one flank marker only 9 40194188 85194188 4 - by one flank marker only 6907110 rat Mcs28 Mammary carcinoma susceptibility QTL 28 5 6904173 D5Uwm82 6904193 D5Uwm92 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 5684388 21205740 Mcs14 (sub_region) 5 84254534 84549684 1 - by flanking markers 6907090 WF.WKY-(D5Uwm78-D5Uwm93)/Uwm 5 80154593 80451339 1 - by flanking markers 5 77743239 78039084 1 - by flanking markers 6907115 rat Mcs29 Mammary carcinoma susceptibility QTL 29 5 6904179 D5Uwm85 6904185 D5Uwm88 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary gland tumor incidence Experimental Mammary Neoplasms 5684388 21205740 Mcs14 (sub_region) 5 84329164 84499632 1 - by flanking markers 6907100 WF.WKY-(D5Uwm82-D5Uwm91)/Uwm 5 80229223 80401274 1 - by flanking markers 5 77816155 77988860 1 - by flanking markers 6907363 rat Bp357 Blood pressure QTL 357 2 4.1 0.002 10386 D2Wox15 11108 D2Wox19 10386 D2Wox15 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 61058 9329963 2 162863444 207863444 4 - by one flank marker only 2 136212270 181212270 4 - by one flank marker only 60990 61015 LH/MavRrrc LN/MavRrrc 2 143447078 188447078 4 - by one flank marker only 2 129540907 174540907 4 - by one flank marker only 6909122 rat Insul22 Insulin level QTL 22 4 4.63 36127 D4Rat9 34943 D4Rat30 35625 D4Rat14 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) decreased circulating insulin level 1626640 17213368 dominant 4 23916923 140915120 1 - by flanking markers 4 23537363 74625985 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 4 23991721 76238799 1 - by flanking markers 4 26907285 75585128 1 - by flanking markers 6909128 rat Pancm4 Pancreatic morphology QTL 4 4 11.35 36127 D4Rat9 34943 D4Rat30 35675 D4Rat28 pancreas mass (VT:0010144) pancreas wet weight (CMO:0000626) decreased pancreas weight 1626640 17213368 4 23916923 140915120 1 - by flanking markers 4 23537363 74625985 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 4 23991721 76238799 1 - by flanking markers 4 26907285 75585128 1 - by flanking markers 7175096 rat Tcs1 T cell selection QTL 1 20 1303324 Brd2 1303306 Cuta T cell selection trait (VT:0004917) expression 7175101;8662970 22391806 20 7323184 7592657 1 - by flanking markers 20 4864606 5176689 1 - by flanking markers 634373 2307301 DA/ZtmRhd DA.LEW.RT1f-(D20Wox15-D20Wox13)/Rhd 20 3910555 5533640 1 - by flanking markers 12743640 DA.E3-(RT1-DMa-Ggnbp1) 20 4727078 5024580 1 - by flanking markers 7175099 rat Tcs2 T cell selection QTL 2 20 735096 RT1-DMb 620731 Btnl2 T cell selection trait (VT:0004917) expression 7175101;8662970 22391806 20 6236503 7288114 1 - by flanking markers 20 4625383 4829535 1 - by flanking markers 634373 2307301 DA/ZtmRhd DA.LEW.RT1f-(D20Wox15-D20Wox13)/Rhd 20 3945383 4156365 1 - by flanking markers 20 4504002 4693102 1 - by flanking markers 7204484 rat Bp358 Blood pressure QTL 358 12 0.001 5683878 D12Hmgc3 5683884 D12Hmgc6 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased mean systemic arterial blood pressure;increased urine protein level Albuminuria;hypertension;proteinuria 7204442;8693701;9685385 22868394;25001272;25320330 12 17102817 24300160 1 - by flanking markers 5683890 SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi 12 15085585 22283507 1 - by flanking markers 12 13008296 19212979 1 - by flanking markers 7205510 rat Activ5 Activity QTL 5 16 3.78 2.8E-4 41248 D16Rat58 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) acute stress disorder 2306974 19089625 16 46234202 90051983 5 - by peak with adj size 16 46718586 90238779 5 - by peak with adj size F2 of reciprocal crosses 61008 2292168 WAG ISIAH 16 46558188 90668790 5 - by peak with adj size 16 42396345 84729064 5 - by peak with adj size 7207480 rat Bss105 Bone structure and strength QTL 105 4 8.1 35070 D4Rat57 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 1549683 16059631 4 174127594 219127594 5 - by peak with adj size 4 112039347 157039347 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 4 109636356 154636356 5 - by peak with adj size 4 109827074 154827074 5 - by peak with adj size 7207481 rat Bss106 Bone structure and strength QTL 106 5 7.9 35060 D5Rat29 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207482 rat Bss107 Bone structure and strength QTL 107 2 7.0 34864 D2Rat67 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 7207484 rat Bss108 Bone structure and strength QTL 108 2 5.3 34864 D2Rat67 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 7207486 rat Bss109 Bone structure and strength QTL 109 5 35060 D5Rat29 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207488 rat Bss110 Bone structure and strength QTL 1 5 8.4 35060 D5Rat29 femur strength trait (VT:0010010) femur stiffness (CMO:0001674) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207490 rat Bss111 Bone structure and strength QTL 111 2 6.4 34864 D2Rat67 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 7207491 rat Bss112 Bone structure and strength QTL 112 5 7.0 35060 D5Rat29 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207805 rat Bmd88 Bone mineral density QTL 88 9 4.0 40738 D9Rat130 40916 D9Rat123 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 2293456 18282130 9 26333329 63071752 1 - by flanking markers 9 20102034 55470344 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 9 27486036 63264281 1 - by flanking markers 9 23754024 58157242 1 - by flanking markers 7207808 rat Bmd89 Bone mineral density QTL 89 2 4.1 40462 D2Rat280 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) 2293456 18282130 2 111366095 156366095 5 - by peak with adj size 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 7207811 rat Bmd90 Bone mineral density QTL 90 10 5.2 40302 D10Rat162 37900 D10Rat124 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 7207814 rat Bmd91 Bone mineral density QTL 91 9 3.5 40080 D9Rat144 40738 D9Rat130 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 2293456 18282130 9 26333448 88080598 1 - by flanking markers 9 20102447 81885455 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 9 27486155 88333183 1 - by flanking markers 9 23754144 83851531 1 - by flanking markers 7207885 rat Glom27 Glomerulus QTL 27 13 3.9 34945 D13Rat51 36699 D13Rat1 39262 D13Rat86 kidney glomerulus integrity trait (VT:0010546) kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139) glomerulonephritis anti-basement membrane glomerulonephritis;crescentic glomerulonephritis 7207870 22445570 2599;71069;631331 Fcer1g;Fcgr2a;Fcgr2b 13 29680295 113387011 1 - by flanking markers 13 10556042 106075835 1 - by flanking markers 737922 1358112 LEW/SsNHsd WKY/NCrl 13 24502279 108770533 1 - by flanking markers 13 20605871 101339738 1 - by flanking markers 7243862 rat Mcs30 Mammary carcinoma susceptibility QTL 30 12 8.62 39814 D12Rat57 41960 D12Arb2 39744 D12Rat59 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7327193;7243871 24023717 1307034 Fry 12 1236564 12361764 1 - by flanking markers 12 1581198 3438700 2 - by one flank and peak markers 10011 61109 COP/OlaHsd F344/NHsd 12 1258139 10257059 1 - by flanking markers 12 797729 8525593 1 - by flanking markers 7247442 rat Uae39 Urinary albumin excretion QTL 39 19 66451 D19Uia1 39128 D19Rat34 40950 D19Rat74 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 19 2413720 69195220 2 - by one flank and peak markers 19 2264957 50012399 2 - by one flank and peak markers 10041 724574 SS/Jr SHR/NHsd 19 2432963 47217667 2 - by one flank and peak markers 19 2187927 46708701 2 - by one flank and peak markers 7365049 rat Bp359 Blood pressure QTL 359 5 7365009 rs105835643 7365016 rs106808193 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 7364997;10755344 22860086;22912817 68945;737548 Cyp4a1;EDN2 Bp292 (sub_region) 5 137146119 143913027 1 - by flanking markers 5 134909988 141744732 1 - by flanking markers 7365043 SS.SR-(rs65785750-rs106808193)/Opaz 5 133351969 140120264 1 - by flanking markers 5 128071929 134724733 1 - by flanking markers 7387227 rat Uae40 Urinary albumin excretion QTL 40 4 2.9 0.0052 7387228 rs8168428 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 4 15986671 60986671 5 - by peak with adj size 4 15103232 60103232 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 4 16149941 61149941 5 - by peak with adj size 4 17946999 62946999 5 - by peak with adj size 7387235 rat Uae41 Urinary albumin excretion QTL 41 10 5.26 0.1874 7387245 rs8165230 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 10 1 28393470 5 - by peak with adj size 10 1 29537210 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 10 1 29592136 5 - by peak with adj size 10 1 29497586 5 - by peak with adj size 7387267 rat Uae42 Urinary albumin excretion QTL 42 14 0.61 7387248 rs105610447 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 14 23845575 68845575 5 - by peak with adj size 14 24876732 69876732 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 18 21639491 66639491 5 - by peak with adj size 14 22167967 67167967 5 - by peak with adj size 7387280 rat Uae43 Urinary albumin excretion QTL 43 13 5.69 0.4174 7387249 rs8156450 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 13 77035361 118718031 5 - by peak with adj size 13 70309799 111154910 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 13 72583716 114033958 5 - by peak with adj size 13 66451204 106807694 5 - by peak with adj size 7387283 rat Uae44 Urinary albumin excretion QTL 44 20 0.1712 7387255 rs8153618 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 20 1 29437823 5 - by peak with adj size 20 1 26162594 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 20 1 27357423 5 - by peak with adj size 20 1 26123605 5 - by peak with adj size 7387289 rat Uae45 Urinary albumin excretion QTL 45 1 2.86 0.0021 7387284 rs8158000 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7387321;7365117 22968639;20159938 additive 1 251578826 290094216 5 - by peak with adj size 1 229695468 267910886 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 1 244148899 282763074 5 - by peak with adj size 1 223262787 260522016 5 - by peak with adj size 7387292 rat Kidm42 Kidney mass QTL 42 12 3.03 4.0E-4 7387286 rs8164304 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) increased kidney weight Albuminuria 7365117 20159938 additive 12 1 40333461 5 - by peak with adj size 12 1 36719145 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 12 1 38334225 5 - by peak with adj size 12 1 36247923 5 - by peak with adj size 7387306 rat Bw124 Body weight QTL 124 3 3.2 3.0E-4 7387301 rs8152181 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 7365117 20159938 additive 3 95458497 140458497 5 - by peak with adj size 3 83621705 128621705 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 3 88910015 133910015 5 - by peak with adj size 3 84091273 129091273 5 - by peak with adj size 7387312 rat Bw125 Body weight QTL 125 10 3.0 0.0047 7387304 rs8163932 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight (CMO:0000356) increased retroperitoneal fat pad weight obesity 7365117 20159938 additive 10 67668577 112200500 5 - by peak with adj size 10 69039078 110718848 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 10 67880046 112626471 5 - by peak with adj size 10 64890616 107211142 5 - by peak with adj size 7387318 rat Stl32 Serum triglyceride level QTL 32 2 3.2 3.0E-4 7387293 rs8160961 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Albuminuria 7365117 20159938 additive 2 41645759 86645759 5 - by peak with adj size 2 22134570 67134570 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 2 22612952 67612952 5 - by peak with adj size 2 22384627 67384627 5 - by peak with adj size 7394701 rat Uae46 Urinary albumin excretion QTL 46 1 3.6 0.0056 37902 D1Rat169 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117;7387321 20159938;22968639 additive 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 7394708 rat Emca11 Estrogen-induced mammary cancer QTL 11 5 41576 D5Rat151 36687 D5Rat25 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 7364727 23151807 2323;2324 Cdkn2a;Cdkn2b 5 107580080 120980183 1 - by flanking markers 5 104231741 118805723 1 - by flanking markers 5135475 ACI.BN-(D5Rat60-D5Rat115)/Shul 5 103580245 117037276 1 - by flanking markers 5 99753548 113061097 1 - by flanking markers 7394710 rat Emca12 Estrogen-induced mammary cancer QTL 12 5 60485 D5Got42 37362 D5Rat86 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 7364727 23151807 2325 Cdkn2c 5 132878119 142889552 1 - by flanking markers 5 130756424 140741152 1 - by flanking markers 5135472 ACI.BN-(D5Uwm70-D5Rat32)/Shul 5 129038716 139099229 1 - by flanking markers 5 124160767 133749643 1 - by flanking markers 7394712 rat Emca13 Estrogen-induced mammary cancer QTL 13 5 41076 D5Rat121 41576 D5Rat151 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 7364727 23151807 5 14314206 107580201 1 - by flanking markers 5 9396684 104231900 1 - by flanking markers 5509087 ACI.BN-(D5Rat113-D5Rat159)/Shul 5 9514842 103580403 1 - by flanking markers 5 9823266 99753708 1 - by flanking markers 7394826 rat Bw126 Body weight QTL 126 4 0.002 10144 D4Mgh16 1310809 Lancl2 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight 7394775 23312492 3197;70547;1310809;1589007 Npy;Crhr2;Lancl2;Jazf1 Alc22 (sub_region) 4 61427427 153387979 1 - by flanking markers 4 61646674 87236803 1 - by flanking markers 7394818 P.NP-(D4Mgh16-D4Rat173)/Iusm 4 61708103 88565113 1 - by flanking markers 4 62933269 87483707 1 - by flanking markers 7394837 rat Memor18 Memory QTL 18 17 7394842 rs65978719 35258 D17Rat36 exploratory behavior trait (VT:0010471) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) abnormal spatial learning Memory Disorders;learning disability 7394833 23469157 1594794 Smokxl1 Memor5 (sub_region) 17 23744952 68744952 4 - by one flank marker only 17 29663991 74663991 4 - by one flank marker only 17 61355300 67004384 1 - by flanking markers 17 56396477 63640182 1 - by flanking markers 7411542 rat Bw127 Body weight QTL 127 6 5.5 0.001 14.3 37298 D6Rat105 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 6 7284088 52284088 5 - by peak with adj size 6 1 41116093 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 42388212 5 - by peak with adj size 6 1 41223769 5 - by peak with adj size 7411545 rat Bw128 Body weight QTL 128 12 5.2 0.001 22.0 11051 D12Mit2 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 620500;620514 Acacb;Acads Niddm27 (maps to same region) 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411547 rat Bw129 Body weight QTL 129 6 0.001 34729 D12Mgh5 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411549 rat Bw130 Body weight QTL 130 19 5.0 0.001 25.3 11389 D19Mgh2 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 2068;2835;3094 Agrp;Hsd11b2;Nr3c2 Niddm38 (maps to same region) 19 30001115 72914587 5 - by peak with adj size 19 17363203 59218465 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 19177495 62275575 5 - by peak with adj size 19 15455860 57337602 5 - by peak with adj size 7411551 rat Bw131 Body weight QTL 131 2 29.6 0.001 23.7 37816 D2Rat145 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 69309 Fabp4 2 89894169 134894169 5 - by peak with adj size 2 69731592 114731592 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 70132175 115132175 5 - by peak with adj size 2 67942638 112942638 5 - by peak with adj size 7411555 rat Bw132 Body weight QTL 132 2 0.001 35340 D2Rat70 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 620500 Acacb 2 259350386 285068071 5 - by peak with adj size 2 232433276 258207540 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 240679103 266435125 5 - by peak with adj size 2 223389739 249053267 5 - by peak with adj size 7411558 rat Bw133 Body weight QTL 133 4 13.84 0.001 5.4 37592 D4Rat141 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 4 187731662 232731662 5 - by peak with adj size 4 128658759 173658759 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 124442168 169442168 5 - by peak with adj size 4 125590636 170590636 5 - by peak with adj size 7411561 rat Bw134 Body weight QTL 134 5 24.0 0.001 22.8 34057 D5Mit17 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 5 55954492 100954492 5 - by peak with adj size 5 52659478 97659478 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 51804426 96804426 5 - by peak with adj size 5 49463600 94463600 5 - by peak with adj size 7411564 rat Bw135 Body weight QTL 135 5 0.001 39066 D5Rat71 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 5 95532085 140532085 5 - by peak with adj size 5 92932036 137932036 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 91585539 136585539 5 - by peak with adj size 5 87468046 132468046 5 - by peak with adj size 7411566 rat Bw136 Body weight QTL 136 7 10.4 0.001 7.1 37382 D7Rat113 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 7 1 34998235 5 - by peak with adj size 7 1 33473674 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 1 34828535 5 - by peak with adj size 7 1 31962314 5 - by peak with adj size 7411569 rat Bw137 Body weight QTL 137 7 0.001 37258 D7Rat107 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 7 28217659 73217659 5 - by peak with adj size 7 25365521 70365521 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 28204653 73204653 5 - by peak with adj size 7 21921195 66921195 5 - by peak with adj size 7411571 rat Bw138 Body weight QTL 138 9 14.3 0.001 5.8 35575 D9Rat22 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 9 37329677 82329677 5 - by peak with adj size 9 29793022 74793022 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 37642351 82642351 5 - by peak with adj size 9 32535505 77535505 5 - by peak with adj size 7411573 rat Bw139 Body weight QTL 139 14 4.7 0.001 1.8 39426 D14Rat77 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 14 1 41243137 5 - by peak with adj size 14 1 41281546 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 14 1 41333960 5 - by peak with adj size 7411575 rat Bw140 Body weight QTL 140 17 30.2 0.001 26.3 35707 D17Rat43 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 17 54069664 92503511 5 - by peak with adj size 17 59837302 97296363 5 - by peak with adj size 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 52410957 90843779 5 - by peak with adj size 17 48560935 86533673 5 - by peak with adj size 7411577 rat Bw141 Body weight QTL 141 17 0.001 35719 D17Rat51 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 17 69178062 92503511 5 - by peak with adj size 17 74087839 97296363 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 67512657 90843779 5 - by peak with adj size 17 62619516 86533673 5 - by peak with adj size 7411579 rat Bw142 Body weight QTL 142 19 12.7 0.001 6.6 36436 D19Rat4 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 19 46986857 72914587 5 - by peak with adj size 19 33684571 59218465 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411582 rat Foco3 Food consumption QTL 3 5 7.5 0.001 13.8 39066 D5Rat71 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 5 95532085 140532085 5 - by peak with adj size 5 92932036 137932036 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 91585539 136585539 5 - by peak with adj size 5 87468046 132468046 5 - by peak with adj size 7411584 rat Foco4 Food consumption QTL 4 6 4.3 0.001 6.0 35683 D6Rat39 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 6 8905438 53905438 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 44015370 5 - by peak with adj size 6 1 42838846 5 - by peak with adj size 7411586 rat Foco5 Food consumption QTL 5 12 5.4 0.001 19.0 11051 D12Mit2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 Alc10 (maps to same region) 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411588 rat Foco6 Food consumption QTL 6 12 0.001 34729 D12Mgh5 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 620500;620514 Acacb;Acads Alc10 (maps to same region);Alc6 (maps to same region) 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411590 rat Foco7 Food consumption QTL 7 19 6.8 0.001 19.6 39128 D19Rat34 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 19 1 24913847 5 - by peak with adj size 19 1 24765162 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 1 24933090 5 - by peak with adj size 19 1 24688055 5 - by peak with adj size 7411592 rat Foco8 Food consumption QTL 8 9 7.4 0.001 45.6 41556 D9Rat132 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 9 1 39272707 5 - by peak with adj size 9 1 33599535 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 1 40383872 5 - by peak with adj size 9 1 37999212 5 - by peak with adj size 7411595 rat Foco9 Food consumption QTL 9 12 4.0 0.001 20.2 11051 D12Mit2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411597 rat Foco10 Food consumption QTL 10 12 0.001 34729 D12Mgh5 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 620500;620514 Acacb;Acads 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411599 rat Foco11 Food consumption QTL 11 1 18.5 0.001 6.5 33646 D1Mit4 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411601 rat Foco12 Food consumption QTL 12 5 19.7 0.001 8.5 39066 D5Rat71 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 5 95532085 140532085 5 - by peak with adj size 5 92932036 137932036 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 91585539 136585539 5 - by peak with adj size 5 87468046 132468046 5 - by peak with adj size 7411603 rat Foco13 Food consumption QTL 13 6 5.5 0.001 1.6 37298 D6Rat105 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 6 7284088 52284088 5 - by peak with adj size 6 1 41116093 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 42388212 5 - by peak with adj size 6 1 41223769 5 - by peak with adj size 7411605 rat Foco14 Food consumption QTL 14 7 24.1 0.001 22.4 36099 D7Rat25 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 7 41096572 86096572 5 - by peak with adj size 7 38076588 83076588 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 40872682 85872682 5 - by peak with adj size 7 34293282 79293282 5 - by peak with adj size 7411607 rat Foco15 Food consumption QTL 15 7 0.001 40900 D7Rat134 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 7 85533213 130533213 5 - by peak with adj size 7 81536235 126536235 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 85595369 130595369 5 - by peak with adj size 7 75918751 120918751 5 - by peak with adj size 7411609 rat Foco16 Food consumption QTL 16 9 25.6 0.001 9.5 34286 D9Mgh6 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 9 11237901 56237901 5 - by peak with adj size 9 5373734 50373734 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 12425463 57425463 5 - by peak with adj size 9 8952560 53952560 5 - by peak with adj size 7411611 rat Foco17 Food consumption QTL 17 10 18.7 0.001 9.1 36249 D10Rat45 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 727858 Npw Alc12 (maps to same region);Alc5 (maps to same region);Alc9 (maps to same region);Kcal2_m (maps to same region) 10 1 42546405 5 - by peak with adj size 10 1 42733142 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 1 42669970 5 - by peak with adj size 10 1 42315980 5 - by peak with adj size 7411614 rat Foco18 Food consumption QTL 18 10 0.001 38936 D10Rat98 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 10 46483741 91483741 5 - by peak with adj size 10 47691367 92691367 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 46848346 91848346 5 - by peak with adj size 10 44441699 89441699 5 - by peak with adj size 7411641 rat Foco19 Food consumption QTL 19 12 27.7 0.001 13.2 34729 D12Mgh5 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 Alc10 (maps to same region);Alc6 (maps to same region) 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411643 rat Foco20 Food consumption QTL 20 12 0.001 38410 D12Rat53 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 620500 Acacb 12 27880729 54450796 5 - by peak with adj size 12 21363209 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 26098845 52716770 5 - by peak with adj size 12 20328819 46669029 5 - by peak with adj size 7411646 rat Foco21 Food consumption QTL 21 15 23.7 0.001 7.5 36602 D15Rat29 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 15 85887326 109758846 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411648 rat Foco22 Food consumption QTL 22 16 15.0 0.001 5.5 36988 D16Rat15 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 16 57386398 90051983 5 - by peak with adj size 16 57547058 90238779 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 57816357 90668790 5 - by peak with adj size 16 52726464 84729064 5 - by peak with adj size 7411650 rat Foco23 Food consumption QTL 23 20 20.7 0.001 6.7 34280 D20Mgh4 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 Kcal2_m (maps to syntenic region) 20 1 30410692 5 - by peak with adj size 20 1 29380417 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 28375393 5 - by peak with adj size 20 1 29191651 5 - by peak with adj size 7411652 rat Foco24 Food consumption QTL 24 20 0.001 35327 D20Rat10 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 20 15583813 57791882 5 - by peak with adj size 20 11142700 55268282 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 13834309 56205956 5 - by peak with adj size 20 11757515 54435887 5 - by peak with adj size 7411654 rat Foco25 Food consumption QTL 25 7 9.3 0.001 11.5 40900 D7Rat134 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 7 85533213 130533213 5 - by peak with adj size 7 81536235 126536235 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 85595369 130595369 5 - by peak with adj size 7 75918751 120918751 5 - by peak with adj size 7411656 rat Foco26 Food consumption QTL 26 9 9.8 0.001 7.4 35575 D9Rat22 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 9 37329677 82329677 5 - by peak with adj size 9 29793022 74793022 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 37642351 82642351 5 - by peak with adj size 9 32535505 77535505 5 - by peak with adj size 7411658 rat Foco27 Food consumption QTL 27 11 16.2 0.001 15.1 37942 D11Rat46 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 11 63034217 93518069 5 - by peak with adj size 11 58591436 87759784 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 11 59943023 90463843 5 - by peak with adj size 11 56351424 86241447 5 - by peak with adj size 7411660 rat Foco28 Food consumption QTL 28 12 10.9 0.001 11.9 11051 D12Mit2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411662 rat Foco29 Food consumption QTL 29 13 20.8 0.001 17.4 34140 D13Mgh2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 13 19195754 64195754 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 13 14096330 59096330 5 - by peak with adj size 13 9313465 54313465 5 - by peak with adj size 7411664 rat Foco30 Food consumption QTL 30 16 11.0 0.001 5.8 40906 D16Rat73 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 16 1224948 46224948 5 - by peak with adj size 16 1223376 46223376 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 1340741 46340741 5 - by peak with adj size 16 1 44588133 5 - by peak with adj size 7411666 rat Foco31 Food consumption QTL 31 17 11.4 0.001 9.9 39752 D17Rat118 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 17 16409641 61409641 5 - by peak with adj size 17 19150649 64150649 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411668 rat Foco32 Food consumption QTL 32 20 8.0 0.001 7.0 40318 D20Rat60 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 20 1 39737376 5 - by peak with adj size 20 1 37105774 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 37550487 5 - by peak with adj size 20 1 36600972 5 - by peak with adj size 7411712 rat Strs4 Sensitivity to stroke QTL 4 1 8.7 10337 D1Mgh5 37384 D1Rat161 37176 D1Rat178 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia Stroke 7411685 23690346 Strs1 (maps to same region) 1 80946174 97911264 1 - by flanking markers 1 78134304 91611235 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 1 79689548 124689548 4 - by one flank marker only 1 78430536 123430536 4 - by one flank marker only 7411719 rat Strs5 Sensitivity to stroke QTL 5 18 9.4 39308 D18Rat73 34182 D18Mgh3 37628 D18Rat41 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia Stroke 7411685 23690346 18 50804228 66665205 1 - by flanking markers 18 52290789 69013448 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 18 51609032 67502266 1 - by flanking markers 18 49999958 65845095 1 - by flanking markers 7411722 rat Strs6 Sensitivity to stroke QTL 6 5 3.9 36103 D5Rat36 34706 D5Mgh18 3193 Nppa cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia Stroke 7411685 23690346 5 144173708 147610023 1 - by flanking markers 5 141999859 145186817 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 5 140387005 143846157 1 - by flanking markers 5 134972980 138113556 1 - by flanking markers 7411725 rat Strs7 Sensitivity to stroke QTL 7 15 3.8 620732 Ephx2 34805 D15Rat32 37954 D15Rat61 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia;increased systemic arterial blood pressure Stroke;hypertension 7411685 23690346 15 48799823 59747340 1 - by flanking markers 15 45497660 54808556 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 15 42757241 56027084 1 - by flanking markers 15 40289901 49308583 1 - by flanking markers 7421626 rat Bp360 Blood pressure QTL 360 1 0.001 35891 D1Rat19 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 1 5173266 50173266 4 - by one flank marker only 1 1 43872827 4 - by one flank marker only 7421599 SS.LEW-(D1Chm64-D1Rat19)/Ayd 1 4578693 49578693 4 - by one flank marker only 1 4393289 49393289 4 - by one flank marker only 7421628 rat Bp361 Blood pressure QTL 361 1 0.001 62475 D1Uia4 39428 D1Rat320 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 Bp310 (interacts with) 1 63580258 126980655 1 - by flanking markers 1 64343599 119536913 1 - by flanking markers 7421606 SS.LEW-(D1Uia4-D1Rat320)/Ayd 1 64588516 125875986 1 - by flanking markers 1 66023617 118608521 1 - by flanking markers 7421630 rat Bp362 Blood pressure QTL 362 1 0.001 39428 D1Rat320 34517 D1Mgh32 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 1 126980427 269885827 1 - by flanking markers 1 119536684 247882384 1 - by flanking markers 7421603 SS.LEW-(D1Rat320-D1Mgh32)/Ayd 1 125875758 262433692 1 - by flanking markers 1 118608292 241799120 1 - by flanking markers 7488904 rat Bp363 Blood pressure QTL 363 2 0.001 38068 D2Rat155 3195 Npr1 3195 Npr1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 3195 Npr1 Bp257 (sub_region);Bp364 (interacts with) 2 206293779 209287892 1 - by flanking markers 2 179581946 182740242 1 - by flanking markers 7421645 SS.MNS-(D2Rat155-D2Chm419)/Ayd 2 186889035 189857032 1 - by flanking markers 2 172982062 175950118 1 - by flanking markers 7488925 rat Bp364 Blood pressure QTL 364 2 0.001 61810 Ctsk arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 61810 Ctsk Bp257 (sub_region);Bp363 (interacts with) 2 193659473 238659473 5 - by peak with adj size 2 167900261 212900261 5 - by peak with adj size 7421643 SS.MNS-(D2Chm254-D2Chm161)/Ayd 2 174160958 219160958 5 - by peak with adj size 2 160564068 205564068 5 - by peak with adj size 7488927 rat Bp365 Blood pressure QTL 365 2 0.008 620905 Prkab2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500;9685142 19461651;23814039;25380161 620905 Prkab2 Bp257 (sub_region);Bp279 (interacts with);Bp310 (interacts with) 2 196817598 241817598 5 - by peak with adj size 2 170004527 215004527 5 - by peak with adj size 7421647 SS.MNS-(D2Chm161-D2Chm410)/Ayd 2 177339806 222339806 5 - by peak with adj size 2 162765032 207765032 5 - by peak with adj size 7488929 rat Bp366 Blood pressure QTL 366 2 0.001 34759 D2Rat52 2167 Atp1a1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 2167 Atp1a1 2 219408246 227502148 2 - by one flank and peak markers 2 192478177 200866813 2 - by one flank and peak markers 7421654 SS.MNS-(D2Chm366-D2Rat52)/Ayd 2 199954569 208081195 2 - by one flank and peak markers 2 184974550 193094998 2 - by one flank and peak markers 7488931 rat Bp367 Blood pressure QTL 367 2 0.001 1358019 D2Chm122 1358052 D2Chm90 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 621826 Pfn2 Bp256 (sub_region) 2 164047103 167706680 1 - by flanking markers 2 144445607 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 144631170 148295508 1 - by flanking markers 2 139401804 142323610 1 - by flanking markers 7488933 rat Bp368 Blood pressure QTL 368 2 0.004 1358052 D2Chm90 3098 Mme arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 3098 Mme Bp258 (sub_region) 2 167706439 173278946 1 - by flanking markers 2 147424195 153114515 1 - by flanking markers 7421636 SS.MNS-(D2Chm90-D2Rat38)/Ayd 2 148295267 153880910 1 - by flanking markers 2 142323368 147803808 1 - by flanking markers 7488963 rat Bp369 Blood pressure QTL 369 17 0.001 628708 Zp4 67385 Cacnb2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500;9685142 23814039;25380161 Bp310 (interacts with);Bp370 (interacts with) 17 67248685 83762100 1 - by flanking markers 17 69576957 89078870 1 - by flanking markers 7421621 SS.LEW-(D17Chm131-D17Chm93)/Ayd 17 65497359 82019219 1 - by flanking markers 17 59005649 77910000 1 - by flanking markers 7488966 rat Bp370 Blood pressure QTL 370 17 0.001 38706 D17Rat84 45485 D17Wox9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 Bp369 (interacts with) 17 23473207 63969577 1 - by flanking markers 17 29603712 65900518 1 - by flanking markers 7421623 SS.LEW-(D17Rat84-D17Chm17)/Ayd 17 21490950 62195822 1 - by flanking markers 17 23653184 57246843 1 - by flanking markers 7771603 rat Bp371 Blood pressure QTL 371 2 1.0E-5 7495817 rs106870553 7495821 rs64088007 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased mean systemic arterial blood pressure;decreased systemic arterial diastolic blood pressure;decreased systemic arterial systolic blood pressure 7495755 23861781 1303105 Dear Memor19 (maps to same region) 2 203270720 206602006 1 - by flanking markers 2 176635705 179892073 1 - by flanking markers 7771589 SS.SR-(D2Rat352-rs63922710)/Opaz 2 183864092 187196901 1 - by flanking markers 2 170201741 173290301 1 - by flanking markers 7771605 rat Memor19 Memory QTL 19 2 1.0E-5 7495817 rs106870553 7495821 rs64088007 exploratory behavior trait (VT:0010471) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) impaired spatial learning Memory Disorders;learning disability 7495755 23861781 1303105 Dear Bp371 (maps to same region) 2 203270720 206602006 1 - by flanking markers 2 176635705 179892073 1 - by flanking markers 7771589 SS.SR-(D2Rat352-rs63922710)/Opaz 2 183864092 187196901 1 - by flanking markers 2 170201741 173290301 1 - by flanking markers 7771612 rat Cm80 Cardiac mass QTL 80 1 8.4 34922 D1Rat43 35909 D1Rat74 41012 D1Rat287 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) decreased heart left ventricle weight;heart left ventricle hypertrophy hypertension 7771608 23901062 1 168015290 248763894 2 - by one flank and peak markers 1 153222955 227005733 2 - by one flank and peak markers 737926 1581618 F344/NCrl SHRSP/Bbb 1 144634295 241482368 1 - by flanking markers 1 149448574 221264292 2 - by one flank and peak markers 7794739 rat Bp372 Blood pressure QTL 372 5 0.0058 7777093 D5Mco58 7794805 D5Mco41 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 7495753 23757393 70987;1307814;1309582 Faf1;Zyg11b;Zyg11a Bp156 (sub_region);Bp373 (interacts with) 7794700 SS.LEW-(D5Mco39-D5Mco41)/Mco 5 122679716 130167412 1 - by flanking markers 5 117913688 125222967 1 - by flanking markers 7794743 rat Bp373 Blood pressure QTL 373 5 0.0058 7794807 D5Mco42 7794818 D5Mco47 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 7495753 23757393 1307610 Raver2 Bp157 (sub_region);Bp372 (interacts with) 7794704 SS.LEW-(D5Mco42-D5Mco47)/2Mco 5 116151740 120258073 1 - by flanking markers 5 112175546 116047089 1 - by flanking markers 7794784 rat Mcs31 Mammary carcinoma susceptibility QTL 31 9 2.98 33999 D9Mit5 36325 D9Rat1 41600 D9Rat110 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 628634 Prlh 9 89765913 119437586 1 - by flanking markers 9 75633467 110864247 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 90024661 119983851 1 - by flanking markers 9 77813894 111552878 1 - by flanking markers 7794788 rat Mcs32 Mammary carcinoma susceptibility QTL 32 1 2.61 35166 D1Rat33 36325 D9Rat1 37560 D1Rat155 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 2991;1308810 Anpep;Blm 1 123747670 275658314 2 - by one flank and peak markers 1 115946374 247103468 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 122614824 262664716 2 - by one flank and peak markers 1 115540693 238914717 2 - by one flank and peak markers 7794791 rat Mcs33 Mammary carcinoma susceptibility QTL 33 5 1.93 33680 D5Mit13 38916 D5Rat106 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 620293 Ece1 5 140429780 177180328 2 - by one flank and peak markers 5 138271925 173096209 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 136640731 173707219 2 - by one flank and peak markers 5 131345754 166875058 2 - by one flank and peak markers 7794793 rat Mcs34 Mammary carcinoma susceptibility QTL 34 18 1.54 40576 D18Rat127 40918 D18Rat80 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 3031 Smad2 18 64771076 83650204 2 - by one flank and peak markers 18 66439387 87265094 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 8552782 rat Vie1 Viral induced encephalitis QTL 1 4 26.4 1626708 D4Kini1 42156 D4Arb25 7241149 D4Kini3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 621001 Calcr Bw143 (maps to same region);Bw144 (maps to same region);Vie4 (maps to same region);Vie5 (maps to same region) 4 31693512 148193854 1 - by flanking markers 4 31074957 81729616 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 31825560 83531021 1 - by flanking markers 4 34430484 82490359 1 - by flanking markers 8552791 rat Vie2 Viral induced encephalitis QTL 2 3 4.1 36584 D3Rat6 36759 D3Rat59 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 3 158307259 183740530 2 - by one flank and peak markers 3 147990566 171063335 2 - by one flank and peak markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 3 153412455 177699992 2 - by one flank and peak markers 3 145956084 169034231 2 - by one flank and peak markers 8552796 rat Vie3 Viral induced encephalitis QTL 3 6 2.6 37848 D6Rat100 40332 D6Rat152 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 6 110589216 156897508 2 - by one flank and peak markers 6 100709370 147636619 2 - by one flank and peak markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 6 101207574 147991367 2 - by one flank and peak markers 6 96833997 140994061 2 - by one flank and peak markers 8552801 rat Bw143 Body weight QTL 143 4 7.3 1626708 D4Kini1 42156 D4Arb25 7241149 D4Kini3 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) abnormal body weight Body Weight Changes 7240516 22761571 Bw144 (maps to same region);Vie1 (maps to same region);Vie4 (maps to same region);Vie5 (maps to same region) 4 31693512 148193854 1 - by flanking markers 4 31074957 81729616 1 - by flanking markers intercross;measurement method: 45 days old rats were infected in the whiskers area with 2X106 PFU of HSV-1 and change in body weight from the day of infection to 5 days post-infection (d0-d5)determined 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 31825560 83531021 1 - by flanking markers 4 34430484 82490359 1 - by flanking markers 8552803 rat Bw144 Body weight QTL 144 4 16.0 39704 D4Rat222 42156 D4Arb25 1626708 D4Kini1 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) abnormal body weight Body Weight Changes 7240516 22761571 Bw143 (maps to same region);Vie1 (maps to same region);Vie4 (maps to same region);Vie5 (maps to same region) 4 19564454 31693512 1 - by flanking markers 4 19044128 31074957 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 19618866 31825560 1 - by flanking markers 4 22710685 34430484 1 - by flanking markers 8552805 rat Bw145 Body weight QTL 145 10 2.2 38824 D10Rat78 36878 D10Rat219 35228 D10Rat29 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) abnormal body weight Body Weight Changes 7240516 22761571 10 42987979 80884595 1 - by flanking markers 10 43361250 81986757 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 10 43188659 81042642 1 - by flanking markers 10 41944526 78307017 1 - by flanking markers 8552807 rat Vie4 Viral induced encephalitis QTL 4 4 7.3 1626708 D4Kini1 10144 D4Mgh16 7241149 D4Kini3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 Bw143 (maps to same region);Bw144 (maps to same region);Vie1 (maps to same region);Vie5 (maps to same region) 4 61427664 148193854 1 - by flanking markers 4 61646915 81729616 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 61708341 83531021 1 - by flanking markers 4 62933508 82490359 1 - by flanking markers 8552809 rat Vie5 Viral induced encephalitis QTL 5 4 25.3 1626708 D4Kini1 42156 D4Arb25 7241149 D4Kini3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 Bw143 (maps to same region);Bw144 (maps to same region);Vie1 (maps to same region);Vie4 (maps to same region) 4 31693512 148193854 1 - by flanking markers 4 31074957 81729616 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 31825560 83531021 1 - by flanking markers 4 34430484 82490359 1 - by flanking markers 8552891 rat Epfw5 Epididymal fat weight QTL 5 1 4.4 38570 D1Rat240 11202 D1Wox28 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) decreased epididymal fat pad weight Weight Loss 8552892 24099777 1303323 Slc22a18 1 217580043 262580043 4 - by one flank marker only 1 198079308 243079308 4 - by one flank marker only intercross 629465 631577 SHR/NCrlCrlj SHR/Izm 1 210652654 255652654 4 - by one flank marker only 1 193113876 238113876 4 - by one flank marker only 8552900 rat Pigfal1 Plasma insulin-like growth factor 1 level QTL 1 1 7.4 14.5 37960 D1Rat196 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 1 36782523 81782523 5 - by peak with adj size 1 32584029 77584029 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 1 35854167 80854167 5 - by peak with adj size 1 34836858 79836858 5 - by peak with adj size 8552903 rat Pigfal2 Plasma insulin-like growth factor 1 level QTL 2 4 7.3 147.7 38776 D4Rat142 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 4 1 28376172 5 - by peak with adj size 4 1 27327405 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 1 28352196 5 - by peak with adj size 4 1 31934116 5 - by peak with adj size 8552906 rat Pigfal3 Plasma insulin-like growth factor 1 level QTL 3 4 41102 D4Rat151 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 8552908 rat Pigfal4 Plasma insulin-like growth factor 1 level QTL 4 5 6.6 11.3 34168 D5Mgh22 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 5 138453703 177180328 5 - by peak with adj size 5 135084412 173096209 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 134712342 173707219 5 - by peak with adj size 5 128506074 166875058 5 - by peak with adj size 8552910 rat Pigfal5 Plasma insulin-like growth factor 1 level QTL 5 6 4.3 9.1 35911 D6Rat33 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 6 29146795 74146795 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 19417887 64417887 5 - by peak with adj size 8552912 rat Pigfal6 Plasma insulin-like growth factor 1 level QTL 6 12 5.0 9.1 61278 D12Arb5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 12 11147464 54450796 5 - by peak with adj size 12 6630245 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223630 52716770 5 - by peak with adj size 12 5564498 46669029 5 - by peak with adj size 8552918 rat Pigfal7 Plasma insulin-like growth factor 1 level QTL 7 12 34729 D12Mgh5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 8552920 rat Pigfal8 Plasma insulin-like growth factor 1 level QTL 8 15 3.0 4.5 40358 D15Rat110 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 15 1 41712083 5 - by peak with adj size 15 1 36290302 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 15 1 37708474 5 - by peak with adj size 15 1 34723002 5 - by peak with adj size 8552928 rat Pigfal9 Plasma insulin-like growth factor 1 level QTL 9 17 9.0 15.4 34120 D17Mgh5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 17 28671746 73671746 5 - by peak with adj size 17 36604895 81604895 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 30975228 75975228 5 - by peak with adj size 17 28409147 73409147 5 - by peak with adj size 8552935 rat Pigfal10 Plasma insulin-like growth factor 1 level QTL 10 19 5.7 9.7 35959 D19Rat15 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 19 4307913 49307913 5 - by peak with adj size 19 1 37926274 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 1 38221845 5 - by peak with adj size 19 1 36824771 5 - by peak with adj size 8552948 rat Pigfal11 Plasma insulin-like growth factor 1 level QTL 11 1 4.7 7.7 37960 D1Rat196 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 1 36782523 81782523 5 - by peak with adj size 1 32584029 77584029 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 1 35854167 80854167 5 - by peak with adj size 1 34836858 79836858 5 - by peak with adj size 8552950 rat Pigfal12 Plasma insulin-like growth factor 1 level QTL 12 3 7.3 21.8 37032 D3Rat66 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 3 36313853 81313853 5 - by peak with adj size 3 25533304 70533304 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 29682732 74682732 5 - by peak with adj size 3 28249687 73249687 5 - by peak with adj size 8552952 rat Pigfal13 Plasma insulin-like growth factor 1 level QTL 13 3 36759 D3Rat59 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 3 154109859 183740530 5 - by peak with adj size 3 140943669 171063335 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 148034701 177699992 5 - by peak with adj size 3 138799500 169034231 5 - by peak with adj size 8552954 rat Pigfal14 Plasma insulin-like growth factor 1 level QTL 14 5 9.0 14.2 34212 D5Mgh5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 5 26528860 71528860 5 - by peak with adj size 5 22999452 67999452 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 21904363 66904363 5 - by peak with adj size 5 21226744 66226744 5 - by peak with adj size 8552960 rat Pigfal15 Plasma insulin-like growth factor 1 level QTL 15 5 34441 D5Mgh20 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 5 120552072 165552072 5 - by peak with adj size 5 118425279 163425279 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 116767924 161767924 5 - by peak with adj size 5 111416838 156416838 5 - by peak with adj size 8552962 rat Pigfal16 Plasma insulin-like growth factor 1 level QTL 16 6 9.4 10.4 37298 D6Rat105 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 6 7284088 52284088 5 - by peak with adj size 6 1 41116093 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 42388212 5 - by peak with adj size 6 1 41223769 5 - by peak with adj size 8552964 rat Pigfal17 Plasma insulin-like growth factor 1 level QTL 17 12 3.5 2.6 34729 D12Mgh5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 8552966 rat Pigfal18 Plasma insulin-like growth factor 1 level QTL 18 17 8.7 11.7 39752 D17Rat118 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 17 16409641 61409641 5 - by peak with adj size 17 19150649 64150649 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8552968 rat Pigfal19 Plasma insulin-like growth factor 1 level QTL 19 18 11.4 29.5 39726 D18Rat111 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 18 1 26009785 5 - by peak with adj size 18 1 26107031 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 1 25999214 5 - by peak with adj size 18 1 25758124 5 - by peak with adj size 8655649 rat Arrd1 Age-related retinal degeneration QTL 1 1 4.89 35569 D1Rat30 38192 D1Rat219 retinal layer morphology trait (VT:0003727) percentage of study population developing retinopathy during a period of time (CMO:0002453) abnormal retina layer morphology macular degeneration 9685464;7794750 25563673;22300709 1309649 Rlbp1 Arrd2 (interacts with) 1 107049754 209588735 1 - by flanking markers 1 100539980 188654926 1 - by flanking markers intercross 68114 8655639 OXYS/Nov WAG/Nov 1 106002252 202571904 1 - by flanking markers 1 100357752 183970443 1 - by flanking markers 8655655 rat Arrd2 Age-related retinal degeneration QTL 2 1 7.79 38192 D1Rat219 34971 D1Rat81 retinal layer morphology trait (VT:0003727) percentage of study population developing retinopathy during a period of time (CMO:0002453) abnormal retina layer morphology macular degeneration 9685464;7794750 25563673;22300709 1306070;1307581;1311656;1565754 Rom1;Bbs1;Best1;Fxn Arrd1 (interacts with);Arrd3 (maps to same region) 1 209588496 272245383 1 - by flanking markers 1 188654686 250119874 1 - by flanking markers intercross 68114 8655639 OXYS/Nov WAG/Nov 1 202571665 264802994 1 - by flanking markers 1 183970203 243914901 1 - by flanking markers 8655855 rat Arrd3 Age-related retinal degeneration QTL 3 1 3.07 38192 D1Rat219 34971 D1Rat81 lens clarity trait (VT:0001304) cataract incidence/prevalence measurement (CMO:0001585) abnormal lens morphology cataract 7794750;9685464 22300709;25563673 Arrd2 (maps to same region) 1 209588496 272245383 1 - by flanking markers 1 188654686 250119874 1 - by flanking markers intercross 68114 8655639 OXYS/Nov WAG/Nov 1 202571665 264802994 1 - by flanking markers 1 183970203 243914901 1 - by flanking markers 8655906 rat Rf60 Renal function QTL 60 4 3.8 38908 D4Rat126 36870 D4Rat33 42156 D4Arb25 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) decreased renal glomerular filtration rate Diabetic Nephropathies 8552897 24192394 4 26562048 146541058 1 - by flanking markers 4 26178307 80205504 1 - by flanking markers intercross 631573 1357191 SBN/Ygl CDS/Ygl 4 26654749 81874227 1 - by flanking markers 4 29494195 81006281 1 - by flanking markers 8655945 rat Rf61 Renal function QTL 61 13 3.6 37844 D13Rat85 33644 D13Mit4 34769 D13Rat33 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) decreased renal glomerular filtration rate Diabetic Nephropathies 8552897 24192394 13 79488981 97381801 1 - by flanking markers 13 72141292 90551272 1 - by flanking markers intercross 631573 1357191 SBN/Ygl CDS/Ygl 13 74568378 92916783 1 - by flanking markers 13 69060519 86800898 1 - by flanking markers 8655949 rat Rf62 Renal function QTL 62 4 22.0 42156 D4Arb25 35625 D4Rat14 42690 D4Rat252 blood urea nitrogen amount (VT:0005265) plasma urea nitrogen level (CMO:0000586) increased blood urea nitrogen level Diabetic Nephropathies 8552897 24192394 4 31693152 44024417 1 - by flanking markers 4 31074596 41729771 1 - by flanking markers intercross 631573 1357191 SBN/Ygl CDS/Ygl 4 31825200 43414792 1 - by flanking markers 4 34430119 44463908 1 - by flanking markers 8655951 rat Rf63 Renal function QTL 63 13 12.2 37844 D13Rat85 37240 D13Rat63 36920 D13Rat46 blood urea nitrogen amount (VT:0005265) plasma urea nitrogen level (CMO:0000586) increased blood urea nitrogen level Diabetic Nephropathies 8552897 24192394 13 79488981 87877411 1 - by flanking markers 13 72141292 80482429 1 - by flanking markers intercross 631573 1357191 SBN/Ygl CDS/Ygl 13 74568378 82995671 1 - by flanking markers 13 69060519 77046890 1 - by flanking markers 8655959 rat Pur32 Proteinuria QTL 32 13 8.4 36920 D13Rat46 34124 D13Mgh6 43004 D13Rat185 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level Diabetic Nephropathies;proteinuria 8552897 24192394 13 84460970 108279142 1 - by flanking markers 13 77336098 101704301 1 - by flanking markers intercross 631573 1357191 SBN/Ygl CDS/Ygl 13 79567081 103613733 1 - by flanking markers 13 74023918 97213863 1 - by flanking markers 8655961 rat Kidm43 Kidney mass QTL 43 4 18.0 42690 D4Rat252 10560 D4Mit12 35160 D4Rat11 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) increased kidney weight Diabetic Nephropathies 8552897 24192394 4 34138110 163844298 1 - by flanking markers 4 33302945 104416171 1 - by flanking markers intercross 631573 1357191 SBN/Ygl CDS/Ygl 4 34277932 99067150 1 - by flanking markers 4 36303261 103194984 1 - by flanking markers 8657050 rat Bw146 Body weight QTL 146 5 19.84 0.001 42319 D5Rat256 1633431 D5Wox37 1633431 D5Wox37 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8657042 24204914 3001 Lepr additive 5 117002345 124443926 1 - by flanking markers 5 114362878 122384169 1 - by flanking markers intercross 8655992 8657051 W-LeprfaNin F344/Nin 5 113059816 120566842 1 - by flanking markers 5 108938288 153938288 4 - by one flank marker only 8657410 rat Bp374 Blood pressure QTL 374 10 41468 D10Rat155 1578931 D10Chm171 heart left ventricle size trait (VT:0002753) heart left ventricle end-diastolic diameter (CMO:0000982) heart left ventricle hypertrophy Hypertrophy;Ventricular Dysfunction, Left 9685142;8657382 25380161;23773896 3645 Ccl2 10 69020437 69797898 1 - by flanking markers 10 70229781 71032765 1 - by flanking markers 8657392 SS.LEW-(D10Rat155-D10Chm171)/Ayd 10 69385595 70167191 1 - by flanking markers 10 66978955 67750281 1 - by flanking markers 8662350 rat Eae35 Experimental allergic encephalomyelitis QTL 35 4 6.2 1628377 D4Got215 42708 D4Rat232 10560 D4Mit12 blood tumor necrosis factor amount (VT:0008552) inflammatory exudate tumor necrosis factor level (CMO:0001435) CNS inflammation Experimental Autoimmune Encephalomyelitis;Experimental Autoimmune Neuritis;arthritis 8662358;8662331 24312603;20505148 708351 Kdm3a 4 163276554 164411864 2 - by one flank and peak markers 4 101974044 104998251 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 98500164 99633958 2 - by one flank and peak markers 4 100834579 103761084 1 - by flanking markers 8662454 rat Vetf3 Vascular elastic tissue fragility QTL 3 5 27.4 37784 D5Rat59 37440 D5Rat84 39686 D5Rat119 artery integrity trait (VT:0010639) number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562) abnormal aorta elastic tissue morphology 8662443;8662864 17356016;24790086 620199;621017;621349;708554;727793;1309577 Mmp16;Lyn;Kcnb2;Sulf1;Rdh10;Pi15 Vetf1 (maps to same region) 5 1662934 75720404 1 - by flanking markers 5 1368223 71971744 1 - by flanking markers backcross 631594 8662449 BN/Rj LOU/MBbb 5 1666587 71552720 1 - by flanking markers 5 2282226 69540447 1 - by flanking markers 8662816 rat Vetf4 Vascular elastic tissue fragility QTL 4 3 4.0 38194 D3Rat109 39418 D3Rat141 39612 D3Rat146 renal artery integrity trait (VT:0010642) number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563) abnormal renal artery morphology 8662443 17356016 620908 Fbn1 3 67717362 171509215 1 - by flanking markers 3 56952839 159783868 1 - by flanking markers backcross 631594 8662449 BN/Rj LOU/MBbb 3 61241033 165369047 1 - by flanking markers 3 59242096 157323038 1 - by flanking markers 8662823 rat Vetf5 Vascular elastic tissue fragility QTL 5 8 1.9 35663 D8Rat51 41212 D8Rat126 41122 D8Rat159 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) patent ductus arteriosus patent ductus arteriosus 8662443 17356016 3142;3143;3144;621395 Myl3;Myo5a;Myo1e;Myo9a 8 30947236 106630895 1 - by flanking markers 8 29559446 103815825 1 - by flanking markers backcross 631594 8662449 BN/Rj LOU/MBbb 8 30918112 107206309 1 - by flanking markers 8 28242912 99525068 1 - by flanking markers 8662828 rat Vetf6 Vascular elastic tissue fragility QTL 6 9 3.9 37604 D9Rat76 36908 D9Rat4 35575 D9Rat22 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) patent ductus arteriosus patent ductus arteriosus 8662443 17356016 70921;70994;71029;628855;1598796 Col5a2;Myo1b;Col3a1;Myl12b;Myl1 9 40929725 98282881 1 - by flanking markers 9 33496794 90697021 1 - by flanking markers backcross 631594 8662449 BN/Rj LOU/MBbb 9 41261034 98606834 1 - by flanking markers 9 36962359 92058970 1 - by flanking markers 8662832 rat Vetf7 Vascular elastic tissue fragility QTL 7 2 3.5 39370 D2Rat212 38852 D2Rat165 37672 D2Rat87 aorta elastin amount (VT:0003905) aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002) abnormal aorta elastin content patent ductus arteriosus 8662443 17356016 2 103429722 256152482 1 - by flanking markers 2 82761368 230023720 1 - by flanking markers backcross 631594 8662449 BN/Rj LOU/MBbb 2 83754907 237610852 1 - by flanking markers 2 81689826 221035911 1 - by flanking markers 8662836 rat Vetf8 Vascular elastic tissue fragility QTL 8 2 0.66 39858 D2Rat205 35162 D2Rat38 39858 D2Rat205 thoracic aorta molecular composition trait (VT:0010568) aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003) abnormal aorta elastic tissue morphology 8662443 17356016 2 130354471 175354471 4 - by one flank marker only 2 110102371 155102371 4 - by one flank marker only backcross 631594 8662449 BN/Rj LOU/MBbb 2 110965721 155965721 4 - by one flank marker only 2 104559726 149559726 4 - by one flank marker only 8662843 rat Vetf9 Vascular elastic tissue fragility QTL 9 2 2.05 36213 D2Rat40 41066 D2Rat247 35425 D2Rat51 thoracic aorta molecular composition trait (VT:0010568) aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003) abnormal aorta elastic tissue morphology 8662443 17356016 2 189197858 261576629 1 - by flanking markers 2 163154227 244567117 2 - by one flank and peak markers backcross 631594 8662449 BN/Rj LOU/MBbb 2 169852670 243026643 1 - by flanking markers 2 157142078 226277316 1 - by flanking markers 8662860 rat Vetf10 Vascular elastic tissue fragility QTL 10 10 38062 D10Rat96 36203 D10Rat27 35485 D10Rat64 artery integrity trait (VT:0010639) number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562) abnormal aorta elastic tissue morphology 8662443 17356016 3136;3138;3742;71000 Myh11;Myh3;Sparc;Myh10 Vetf2 (maps to same region) 10 5044642 74127968 1 - by flanking markers 10 6172610 77092169 1 - by flanking markers backcross 631594 8662449 BN/Rj LOU/MBbb 10 6229095 75983805 1 - by flanking markers 10 6154182 73453136 1 - by flanking markers 8693608 rat Alc24 Alcohol consumption QTL 24 1 2.3 0.74 8693307 rs64262745 8693308 rs8170917 8663442 rs105049829 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 1 167289907 185903330 1 - by flanking markers 1 153326053 172021329 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 1 161072673 178935582 1 - by flanking markers 1 150452391 168228760 1 - by flanking markers 8693618 rat Alc25 Alcohol consumption QTL 25 1 3.0 0.28 8693309 rs107452597 8693311 rs64209861 8663445 rs64042903 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 1 234574271 256490738 1 - by flanking markers 1 213847769 234642714 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 1 227509470 249252048 1 - by flanking markers 1 207987464 228627600 1 - by flanking markers 8693622 rat Alc26 Alcohol consumption QTL 26 2 2.4 0.667 8693312 rs105495306 8693416 rs13448492 8663448 rs63999739 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 2 256252917 276257792 1 - by flanking markers 2 230127295 250896811 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 2 237712398 257579826 1 - by flanking markers 2 221136523 241305619 1 - by flanking markers 8693632 rat Alc27 Alcohol consumption QTL 27 6 2.2 0.791 8693338 rs107423234 8693339 rs66395656 8693214 rs107511300 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 6 44031135 63475800 1 - by flanking markers 6 35121447 53078918 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 6 34257766 53855198 1 - by flanking markers 6 34323357 51121479 1 - by flanking markers 8693635 rat Alc28 Alcohol consumption QTL 28 12 2.7 0.439 8693404 rs64151264 8693405 rs65296962 8693216 rs106542192 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 12 31064575 52504616 1 - by flanking markers 12 24280431 44670612 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 12 29113609 50757185 1 - by flanking markers 12 23081340 44726024 1 - by flanking markers 8693637 rat Alc29 Alcohol consumption QTL 29 1 2.7 0.258 8693309 rs107452597 8693312 rs105495306 8663445 rs64042903 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 1 234574271 262630025 2 - by one flank and peak markers 1 213847769 239852417 2 - by one flank and peak markers 61098 61099 BXH/Ipcv HXB/Ipcv 1 227509470 255131140 2 - by one flank and peak markers 1 207987464 234238494 2 - by one flank and peak markers 8693641 rat Alc30 Alcohol consumption QTL 30 3 2.0 0.739 8693333 rs13455837 8693334 rs106929875 8663472 rs106373454 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 3 11017022 30321122 1 - by flanking markers 3 6004284 20676398 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 3 5654639 25105730 1 - by flanking markers 3 10434306 24512004 1 - by flanking markers 8693645 rat Alc31 Alcohol consumption QTL 31 6 3.7 0.038 8693335 rs107439214 8693336 rs107592435 8693211 rs107435003 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 6 131214 33467490 1 - by flanking markers 6 270828 24118506 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 6 135053 23600274 1 - by flanking markers 6 17532521 24011952 1 - by flanking markers 8693654 rat Alc32 Alcohol consumption QTL 32 8 2.0 0.755 8693340 rs107402384 8693402 rs105497894 8693215 rs65015946 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 8 94820292 114983859 1 - by flanking markers 8 92944722 112111932 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 8 95319530 115625029 1 - by flanking markers 8 88612425 107550209 1 - by flanking markers 8693658 rat Alc33 Alcohol consumption QTL 33 12 2.1 0.68 8693404 rs64151264 8693406 rs8143351 8693216 rs106542192 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 12 31064575 51333313 1 - by flanking markers 12 24280431 44563227 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 12 29113609 49560679 1 - by flanking markers 12 23081340 43551788 1 - by flanking markers 8693661 rat Alc34 Alcohol consumption QTL 34 1 2.2 0.611 8693309 rs107452597 8693311 rs64209861 8693445 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 1 234574271 256490738 1 - by flanking markers 1 213847769 234642714 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 1 227509470 249252048 1 - by flanking markers 1 207987464 228627600 1 - by flanking markers 8693690 rat Alc35 Alcohol consumption QTL 35 6 2.2 0.606 8693337 rs13452788 8693417 rs64886957 8693211 rs107435003 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 6 9884460 32363317 1 - by flanking markers 6 10098192 21268437 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 6 9974277 22477622 1 - by flanking markers 6 7964167 21301982 1 - by flanking markers 8693697 rat Alc36 Alcohol consumption QTL 36 2 2.0 0.592 8693316 rs105776994 8693332 rs65785626 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 2 252346818 272324965 1 - by flanking markers 2 225986081 245974908 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 2 233013605 253626471 1 - by flanking markers 2 217139753 236660713 1 - by flanking markers 8693699 rat Alc37 Alcohol consumption QTL 37 6 2.6 0.224 8693337 rs13452788 8693417 rs64886957 8693211 rs107435003 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) increased alcohol consumption alcohol use disorder 8663441 24961585 6 9884460 32363317 1 - by flanking markers 6 10098192 21268437 1 - by flanking markers 61098 61099 BXH/Ipcv HXB/Ipcv 6 9974277 22477622 1 - by flanking markers 6 7964167 21301982 1 - by flanking markers 8694166 rat Bw147 Body weight QTL 147 1 6.83 0.001 12.2 33646 D1Mit4 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8694169 rat Bw148 Body weight QTL 148 5 5.0 0.001 9.7 34168 D5Mgh22 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 5 138453703 177180328 5 - by peak with adj size 5 135084412 173096209 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 134712342 173707219 5 - by peak with adj size 5 128506074 166875058 5 - by peak with adj size 8694173 rat Bw149 Body weight QTL 149 10 4.38 0.001 6.5 38936 D10Rat98 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 10 46483741 91483741 5 - by peak with adj size 10 47691367 92691367 5 - by peak with adj size intercross;measurement method: body weight was taken at 18 weeks of age, at the end of the HPA axis function experiment 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 46848346 91848346 5 - by peak with adj size 10 44441699 89441699 5 - by peak with adj size 8694179 rat Bw150 Body weight QTL 150 12 2.9 0.001 4.4 11051 D12Mit2 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 8694181 rat Bw151 Body weight QTL 151 17 4.36 0.001 7.9 35707 D17Rat43 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 17 54069664 92503511 5 - by peak with adj size 17 59837302 97296363 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 52410957 90843779 5 - by peak with adj size 17 48560935 86533673 5 - by peak with adj size 8694186 rat Bw152 Body weight QTL 152 19 3.34 0.001 6.0 36165 D19Rat13 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 19 14677458 59677458 5 - by peak with adj size 19 2225635 47225635 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 3701835 48701835 5 - by peak with adj size 19 569374 45569374 5 - by peak with adj size 8694189 rat Bw153 Body weight QTL 153 20 3.13 0.001 4.6 34280 D20Mgh4 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 20 1 30410692 5 - by peak with adj size 20 1 29380417 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 28375393 5 - by peak with adj size 20 1 29191651 5 - by peak with adj size 8694194 rat Abfw1 Abdominal fat weight QTL 1 2 11.7 0.001 14.3 40528 D2Rat240 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 2 214964293 259964293 5 - by peak with adj size 2 190451171 235451171 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 197253963 242253963 5 - by peak with adj size 2 182171407 227171407 5 - by peak with adj size 8694196 rat Abfw2 Abdominal fat weight QTL 2 3 16.58 0.001 14.1 37032 D3Rat66 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 3 36313853 81313853 5 - by peak with adj size 3 25533304 70533304 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 29682732 74682732 5 - by peak with adj size 3 28249687 73249687 5 - by peak with adj size 8694198 rat Abfw3 Abdominal fat weight QTL 3 5 16.13 0.001 21.0 34441 D5Mgh20 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 5 120552072 165552072 5 - by peak with adj size 5 118425279 163425279 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 116767924 161767924 5 - by peak with adj size 5 111416838 156416838 5 - by peak with adj size 8694200 rat Abfw4 Abdominal fat weight QTL 4 8 9.07 0.001 9.1 35038 D8Rat16 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 8 78280970 123280970 5 - by peak with adj size 8 76378702 121378702 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8 78805083 123805083 5 - by peak with adj size 8 71888757 116888757 5 - by peak with adj size 8694359 rat Abfw5 Abdominal fat weight QTL 5 10 14.99 0.001 8.0 34128 D10Mgh1 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8694361 rat Abfw6 Abdominal fat weight QTL 6 15 10.2 0.001 6.3 40358 D15Rat110 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 15 1 41712083 5 - by peak with adj size 15 1 36290302 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 15 1 37708474 5 - by peak with adj size 15 1 34723002 5 - by peak with adj size 8694364 rat Abfw7 Abdominal fat weight QTL 7 16 12.22 0.001 7.1 36988 D16Rat15 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 16 57386398 90051983 5 - by peak with adj size 16 57547058 90238779 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 57816357 90668790 5 - by peak with adj size 16 52726464 84729064 5 - by peak with adj size 8694366 rat Abfw8 Abdominal fat weight QTL 8 18 6.38 0.001 3.4 35977 D18Rat8 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 18 48264600 87229863 5 - by peak with adj size 18 49950275 87265094 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 49130920 88201929 5 - by peak with adj size 18 46640675 83828827 5 - by peak with adj size 8694370 rat Bw154 Body weight QTL 154 1 8.91 0.001 31.0 37428 D1Rat200 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 1 111660137 156660137 5 - by peak with adj size 1 104439122 149439122 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 1 110620749 155620749 5 - by peak with adj size 1 103111621 148111621 5 - by peak with adj size 8694374 rat Bw155 Body weight QTL 155 4 3.39 0.001 7.5 41102 D4Rat151 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 8694376 rat Bw156 Body weight QTL 156 11 2.25 0.001 4.5 41428 D11Rat68 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 11 28899265 73899265 5 - by peak with adj size 11 24293499 69293499 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 11 25720038 70720038 5 - by peak with adj size 11 23280456 68280456 5 - by peak with adj size 8694378 rat Bw157 Body weight QTL 157 18 3.59 0.001 7.5 37738 D18Rat57 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 18 30600568 75600568 5 - by peak with adj size 18 32105822 77105822 5 - by peak with adj size intercross intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 31361341 76361341 5 - by peak with adj size 18 29792965 74792965 5 - by peak with adj size 8694383 rat Bw158 Body weight QTL 158 2 7.69 0.001 12.8 40528 D2Rat240 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 2 214964293 259964293 5 - by peak with adj size 2 190451171 235451171 5 - by peak with adj size intercross intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 197253963 242253963 5 - by peak with adj size 2 182171407 227171407 5 - by peak with adj size 8694386 rat Bw159 Body weight QTL 159 3 4.52 0.001 5.6 37032 D3Rat66 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 3 36313853 81313853 5 - by peak with adj size 3 25533304 70533304 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 29682732 74682732 5 - by peak with adj size 3 28249687 73249687 5 - by peak with adj size 8694389 rat Bw160 Body weight QTL 160 5 6.17 0.001 9.6 34441 D5Mgh20 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 5 120552072 165552072 5 - by peak with adj size 5 118425279 163425279 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 116767924 161767924 5 - by peak with adj size 5 111416838 156416838 5 - by peak with adj size 8694392 rat Bw161 Body weight QTL 161 8 8.06 0.001 18.2 35038 D8Rat16 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 8 78280970 123280970 5 - by peak with adj size 8 76378702 121378702 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8 78805083 123805083 5 - by peak with adj size 8 71888757 116888757 5 - by peak with adj size 8694424 rat Bw162 Body weight QTL 162 11 3.8 0.001 3.7 41428 D11Rat68 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 11 28899265 73899265 5 - by peak with adj size 11 24293499 69293499 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 11 25720038 70720038 5 - by peak with adj size 11 23280456 68280456 5 - by peak with adj size 8694427 rat Bw163 Body weight QTL 163 15 4.82 0.001 3.7 37308 D15Rat52 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 15 16980907 61980907 5 - by peak with adj size 8694429 rat Bw164 Body weight QTL 164 16 5.0 0.001 6.9 36988 D16Rat15 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 16 57386398 90051983 5 - by peak with adj size 16 57547058 90238779 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 57816357 90668790 5 - by peak with adj size 16 52726464 84729064 5 - by peak with adj size 8694432 rat Bw165 Body weight QTL 165 18 3.81 0.001 4.5 35977 D18Rat8 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 18 48264600 87229863 5 - by peak with adj size 18 49950275 87265094 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 49130920 88201929 5 - by peak with adj size 18 46640675 83828827 5 - by peak with adj size 8694435 rat Bw166 Body weight QTL 166 2 14.08 0.001 14.6 40528 D2Rat240 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 2 214964293 259964293 5 - by peak with adj size 2 190451171 235451171 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 197253963 242253963 5 - by peak with adj size 2 182171407 227171407 5 - by peak with adj size 8694437 rat Bw167 Body weight QTL 167 3 22.46 0.001 12.4 33901 D3Mit12 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 3 103535022 148535022 5 - by peak with adj size 3 92074676 137074676 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 97009185 142009185 5 - by peak with adj size 3 91797474 136797474 5 - by peak with adj size 8694439 rat Bw168 Body weight QTL 168 4 9.57 0.001 4.5 10145 D4Arb10 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 4 38927571 83927571 5 - by peak with adj size 4 39146820 84146820 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 39208247 84208247 5 - by peak with adj size 4 40433414 85433414 5 - by peak with adj size 8694441 rat Bw169 Body weight QTL 169 5 17.61 0.001 20.7 34441 D5Mgh20 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 5 120552072 165552072 5 - by peak with adj size 5 118425279 163425279 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 116767924 161767924 5 - by peak with adj size 5 111416838 156416838 5 - by peak with adj size 8694446 rat Bw170 Body weight QTL 170 8 12.07 0.001 12.4 35038 D8Rat16 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 8 78280970 123280970 5 - by peak with adj size 8 76378702 121378702 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8 78805083 123805083 5 - by peak with adj size 8 71888757 116888757 5 - by peak with adj size 8694450 rat Bw171 Body weight QTL 171 10 16.22 0.001 7.4 34128 D10Mgh1 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8694453 rat Bw172 Body weight QTL 172 16 8.33 0.001 9.4 40524 D16Rat67 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 16 27242937 72242937 5 - by peak with adj size 16 27616033 72616033 5 - by peak with adj size 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 27519980 72519980 5 - by peak with adj size 16 24325513 69325513 5 - by peak with adj size 9587428 rat Epfw6 Epididymal fat weight QTL 6 2 7.47 0.001 4.9 35340 D2Rat70 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 2 259350386 285068071 5 - by peak with adj size 2 232433276 258207540 5 - by peak with adj size 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 240679103 266435125 5 - by peak with adj size 2 223389739 249053267 5 - by peak with adj size 9589025 rat Epfw7 Epididymal fat weight QTL 7 5 20.66 0.001 12.1 34057 D5Mit17 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 5 55954492 100954492 5 - by peak with adj size 5 52659478 97659478 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 51804426 96804426 5 - by peak with adj size 5 49463600 94463600 5 - by peak with adj size 9589028 rat Epfw8 Epididymal fat weight QTL 8 8 11.78 0.001 22.5 36217 D8Rat29 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 8 53845590 98845590 5 - by peak with adj size 8 52269638 97269638 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9589030 rat Epfw9 Epididymal fat weight QTL 9 10 19.24 0.001 7.8 38936 D10Rat98 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 10 46483741 91483741 5 - by peak with adj size 10 47691367 92691367 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 46848346 91848346 5 - by peak with adj size 10 44441699 89441699 5 - by peak with adj size 9589032 rat Epfw10 Epididymal fat weight QTL 10 11 9.29 0.001 13.3 41428 D11Rat68 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 11 28899265 73899265 5 - by peak with adj size 11 24293499 69293499 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 11 25720038 70720038 5 - by peak with adj size 11 23280456 68280456 5 - by peak with adj size 9589034 rat Epfw11 Epididymal fat weight QTL 11 14 6.0 0.001 8.8 40134 D14Rat91 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 14 61668643 106668643 5 - by peak with adj size 14 61376259 106376259 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 14 60980905 105980905 5 - by peak with adj size 14 55624247 100624247 5 - by peak with adj size 9589041 rat Epfw12 Epididymal fat weight QTL 12 18 17.08 0.001 7.9 35977 D18Rat8 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 18 48264600 87229863 5 - by peak with adj size 18 49950275 87265094 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 49130920 88201929 5 - by peak with adj size 18 46640675 83828827 5 - by peak with adj size 9589044 rat Scfw1 Subcutaneous fat weight QTL 1 2 5.8 0.001 9.0 40528 D2Rat240 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 2 214964293 259964293 5 - by peak with adj size 2 190451171 235451171 5 - by peak with adj size 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 197253963 242253963 5 - by peak with adj size 2 182171407 227171407 5 - by peak with adj size 9589046 rat Scfw2 Subcutaneous fat weight QTL 2 4 5.54 0.001 6.4 38776 D4Rat142 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 4 1 28376172 5 - by peak with adj size 4 1 27327405 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 1 28352196 5 - by peak with adj size 4 1 31934116 5 - by peak with adj size 9589048 rat Scfw3 Subcutaneous fat weight QTL 3 6 4.57 0.001 4.8 37298 D6Rat105 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 6 7284088 52284088 5 - by peak with adj size 6 1 41116093 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 42388212 5 - by peak with adj size 6 1 41223769 5 - by peak with adj size 9589051 rat Scfw4 Subcutaneous fat weight QTL 4 8 3.37 0.001 3.9 36217 D8Rat29 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 8 53845590 98845590 5 - by peak with adj size 8 52269638 97269638 5 - by peak with adj size software package used: MultiQTL software 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9589055 rat Scfw5 Subcutaneous fat weight QTL 5 9 5.55 0.001 5.6 41556 D9Rat132 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 9 1 39272707 5 - by peak with adj size 9 1 33599535 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 1 40383872 5 - by peak with adj size 9 1 37999212 5 - by peak with adj size 9589057 rat Scfw6 Subcutaneous fat weight QTL 6 17 8.62 0.001 27.1 39752 D17Rat118 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) increased body weight Weight Gain;abdominal obesity-metabolic syndrome 8694157 25003539 17 16409641 61409641 5 - by peak with adj size 17 19150649 64150649 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9589093 rat Slep10 Serum leptin concentration QTL 10 2 3.84 0.001 6.1 33850 D2Mit30 blood leptin amount (VT:0005667) plasma leptin level (CMO:0000781) increased circulating leptin level Weight Gain;disease of metabolism 8694157 25003539 2 121970291 166970291 5 - by peak with adj size 2 102201229 147201229 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 102356980 147356980 5 - by peak with adj size 9589097 rat Slep11 Serum leptin concentration QTL 11 4 5.09 0.001 22.2 38776 D4Rat142 blood leptin amount (VT:0005667) plasma leptin level (CMO:0000781) increased circulating leptin level Weight Gain;disease of metabolism 8694157 25003539 4 1 28376172 5 - by peak with adj size 4 1 27327405 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 1 28352196 5 - by peak with adj size 4 1 31934116 5 - by peak with adj size 9589100 rat Slep12 Serum leptin concentration QTL 12 5 5.2 0.001 8.0 11072 D5Mgh2 blood leptin amount (VT:0005667) plasma leptin level (CMO:0000781) increased circulating leptin level Weight Gain;disease of metabolism 8694157 25003539 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9589102 rat Slep13 Serum leptin concentration QTL 13 19 4.63 0.001 7.9 36165 D19Rat13 blood leptin amount (VT:0005667) plasma leptin level (CMO:0000781) increased circulating leptin level Weight Gain;disease of metabolism 8694157 25003539 19 14677458 59677458 5 - by peak with adj size 19 2225635 47225635 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 3701835 48701835 5 - by peak with adj size 19 569374 45569374 5 - by peak with adj size 9589106 rat Insul23 Insulin level QTL 23 3 13.86 0.001 12.1 34304 D3Mgh18 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 3 145760614 183740530 5 - by peak with adj size 3 133941928 171063335 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 139578365 177699992 5 - by peak with adj size 3 131635904 169034231 5 - by peak with adj size 9589129 rat Insul24 Insulin level QTL 24 6 19.06 0.001 12.6 37298 D6Rat105 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 6 7284088 52284088 5 - by peak with adj size 6 1 41116093 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 42388212 5 - by peak with adj size 6 1 41223769 5 - by peak with adj size 9589131 rat Insul25 Insulin level QTL 25 8 11.86 0.001 10.8 36673 D8Rat49 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9589133 rat Insul26 Insulin level QTL 26 9 17.96 0.001 10.6 34286 D9Mgh6 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 9 11237901 56237901 5 - by peak with adj size 9 5373734 50373734 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 12425463 57425463 5 - by peak with adj size 9 8952560 53952560 5 - by peak with adj size 9589136 rat Insul27 Insulin level QTL 27 10 10.46 0.001 19.0 36496 D10Rat37 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 10 12411032 57411032 5 - by peak with adj size 10 12631435 57631435 5 - by peak with adj size 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 12639513 57639513 5 - by peak with adj size 10 11474010 56474010 5 - by peak with adj size 9589141 rat Insul28 Insulin level QTL 28 13 10.82 0.001 6.3 34140 D13Mgh2 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 13 19195754 64195754 5 - by peak with adj size measurement method: at the end of the HPA axis function experiment, animals were fasted overnight, blood samples collected on EDTA, centrifuged at 4000g, plasma extracted and plasma insulin level measured in triplicate with RIA kit (Insik 5, DiaSorin SA, Antony, France) 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 13 14096330 59096330 5 - by peak with adj size 13 9313465 54313465 5 - by peak with adj size 9589149 rat Insul29 Insulin level QTL 29 15 9.06 0.001 4.8 40358 D15Rat110 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 15 1 41712083 5 - by peak with adj size 15 1 36290302 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 15 1 37708474 5 - by peak with adj size 15 1 34723002 5 - by peak with adj size 9589151 rat Insul30 Insulin level QTL 30 17 8.82 0.001 8.4 39752 D17Rat118 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 17 16409641 61409641 5 - by peak with adj size 17 19150649 64150649 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9589153 rat Insul31 Insulin level QTL 31 18 7.15 0.05 3.9 35803 D18Rat25 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 18 1 38514022 5 - by peak with adj size 18 1 43159929 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 1 38753381 5 - by peak with adj size 18 1 42547119 5 - by peak with adj size 9589155 rat Insul32 Insulin level QTL 32 20 6.38 0.001 6.3 34280 D20Mgh4 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level glucose metabolism disease 8694157 25003539 20 1 30410692 5 - by peak with adj size 20 1 29380417 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 28375393 5 - by peak with adj size 20 1 29191651 5 - by peak with adj size 9589158 rat Gluco65 Glucose level QTL 65 9 6.82 0.001 16.9 41556 D9Rat132 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level glucose metabolism disease 8694157 25003539 9 1 39272707 5 - by peak with adj size 9 1 33599535 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 1 40383872 5 - by peak with adj size 9 1 37999212 5 - by peak with adj size 9589164 rat Gluco66 Glucose level QTL 66 13 6.67 0.001 8.3 36695 D13Rat38 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level glucose metabolism disease 8694157 25003539 13 25157799 70157799 5 - by peak with adj size 13 16241378 61241378 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 13 20052477 65052477 5 - by peak with adj size 13 15158722 60158722 5 - by peak with adj size 9589814 rat Gluco67 Glucose level QTL 67 14 4.54 0.001 5.6 39426 D14Rat77 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level glucose metabolism disease 8694157 25003539 14 1 41243137 5 - by peak with adj size 14 1 41281546 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 14 1 41333960 5 - by peak with adj size 9589816 rat Gluco68 Glucose level QTL 68 18 7.25 0.001 32.6 37738 D18Rat57 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level glucose metabolism disease 8694157 25003539 18 30600568 75600568 5 - by peak with adj size 18 32105822 77105822 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 31361341 76361341 5 - by peak with adj size 18 29792965 74792965 5 - by peak with adj size 9589820 rat Insglur3 Insulin/glucose ratio QTL 3 1 10.75 0.001 16.2 37960 D1Rat196 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) insulin resistance Insulin Resistance 8694157 25003539 1 36782523 81782523 5 - by peak with adj size 1 32584029 77584029 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 1 35854167 80854167 5 - by peak with adj size 1 34836858 79836858 5 - by peak with adj size 9590080 rat Insglur4 Insulin/glucose ratio QTL 4 2 28.7 0.001 23.2 38976 D2Rat124 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) insulin resistance Insulin Resistance 8694157 25003539 2 22817824 67817824 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 3686308 48686308 5 - by peak with adj size 9590084 rat Insglur5 Insulin/glucose ratio QTL 5 8 18.54 0.001 6.9 37290 D8Rat77 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) insulin resistance Insulin Resistance 8694157 25003539 8 1 24632035 5 - by peak with adj size 8 1 24001942 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8 1 24608226 5 - by peak with adj size 8 1 24597739 5 - by peak with adj size 9590086 rat Insglur6 Insulin/glucose ratio QTL 6 12 18.97 0.001 12.7 11051 D12Mit2 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) insulin resistance Insulin Resistance 8694157 25003539 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 9590088 rat Insglur7 Insulin/glucose ratio QTL 7 17 20.38 0.001 8.6 39752 D17Rat118 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) insulin resistance Insulin Resistance 8694157 25003539 17 16409641 61409641 5 - by peak with adj size 17 19150649 64150649 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9590090 rat Insglur8 Insulin/glucose ratio QTL 8 19 10.81 0.001 19.7 35959 D19Rat15 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) insulin resistance Insulin Resistance 8694157 25003539 19 4307913 49307913 5 - by peak with adj size 19 1 37926274 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 1 38221845 5 - by peak with adj size 19 1 36824771 5 - by peak with adj size 9590092 rat Insglur9 Insulin/glucose ratio QTL 9 20 18.38 0.001 8.1 35327 D20Rat10 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) insulin resistance Insulin Resistance 8694157 25003539 20 15583813 57791882 5 - by peak with adj size 20 11142700 55268282 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 13834309 56205956 5 - by peak with adj size 20 11757515 54435887 5 - by peak with adj size 9590095 rat Sffal3 Serum free fatty acids level QTL 3 2 6.78 0.001 17.3 41334 D2Rat201 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) increased circulating free fatty acids level lipid metabolism disorder 8694157 25003539 2 46133775 91133775 5 - by peak with adj size 2 27191554 72191554 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 27760301 72760301 5 - by peak with adj size 2 27157160 72157160 5 - by peak with adj size 9590100 rat Sffal4 Serum free fatty acids level QTL 4 4 7.36 0.05 22.9 38776 D4Rat142 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) increased circulating free fatty acids level lipid metabolism disorder 8694157 25003539 4 1 28376172 5 - by peak with adj size 4 1 27327405 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 1 28352196 5 - by peak with adj size 4 1 31934116 5 - by peak with adj size 9590102 rat Sffal5 Serum free fatty acids level QTL 5 7 8.62 0.001 11.1 36715 D7Rat30 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) increased circulating free fatty acids level lipid metabolism disorder 8694157 25003539 7 11712265 56712265 5 - by peak with adj size 7 7839362 52839362 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 11647102 56647102 5 - by peak with adj size 7 5329019 50329019 5 - by peak with adj size 9590104 rat Sffal6 Serum free fatty acids level QTL 6 13 5.81 0.001 8.0 34483 D13Mgh9 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) increased circulating free fatty acids level lipid metabolism disorder 8694157 25003539 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9590107 rat Sffal7 Serum free fatty acids level QTL 7 17 4.81 0.001 6.7 34120 D17Mgh5 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) increased circulating free fatty acids level lipid metabolism disorder 8694157 25003539 17 28671746 73671746 5 - by peak with adj size 17 36604895 81604895 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 30975228 75975228 5 - by peak with adj size 17 28409147 73409147 5 - by peak with adj size 9590109 rat Sffal8 Serum free fatty acids level QTL 8 20 5.32 0.01 19.3 34280 D20Mgh4 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) increased circulating free fatty acids level lipid metabolism disorder 8694157 25003539 20 1 30410692 5 - by peak with adj size 20 1 29380417 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 28375393 5 - by peak with adj size 20 1 29191651 5 - by peak with adj size 9590136 rat Scort3 Serum corticosterone level QTL 3 3 23.37 0.001 15.4 37032 D3Rat66 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 3 36313853 81313853 5 - by peak with adj size 3 25533304 70533304 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 29682732 74682732 5 - by peak with adj size 3 28249687 73249687 5 - by peak with adj size 9590140 rat Scort4 Serum corticosterone level QTL 4 6 14.49 0.001 15.4 35583 D6Rat50 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 6 51267831 96267831 5 - by peak with adj size 6 41096237 86096237 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 41679046 86679046 5 - by peak with adj size 6 38783989 83783989 5 - by peak with adj size 9590142 rat Scort5 Serum corticosterone level QTL 5 7 24.4 0.001 10.4 37382 D7Rat113 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 7 1 34998235 5 - by peak with adj size 7 1 33473674 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 1 34828535 5 - by peak with adj size 7 1 31962314 5 - by peak with adj size 9590144 rat Scort6 Serum corticosterone level QTL 6 8 17.54 0.001 13.7 41122 D8Rat159 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9590147 rat Scort7 Serum corticosterone level QTL 7 12 13.61 0.001 10.2 11051 D12Mit2 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 9590151 rat Scort8 Serum corticosterone level QTL 8 16 8.45 0.001 4.9 39272 D16Rat38 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 16 1 33776832 5 - by peak with adj size 16 1 31112505 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 1 31816439 5 - by peak with adj size 16 1 30836262 5 - by peak with adj size 9590154 rat Scort9 Serum corticosterone level QTL 9 17 23.57 0.001 8.3 39752 D17Rat118 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 17 16409641 61409641 5 - by peak with adj size 17 19150649 64150649 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9590248 rat Scort10 Serum corticosterone level QTL 10 18 19.71 0.001 24.6 39726 D18Rat111 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 18 1 26009785 5 - by peak with adj size 18 1 26107031 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 1 25999214 5 - by peak with adj size 18 1 25758124 5 - by peak with adj size 9590250 rat Scort11 Serum corticosterone level QTL 11 19 23.45 0.001 11.4 35959 D19Rat15 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 19 4307913 49307913 5 - by peak with adj size 19 1 37926274 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 1 38221845 5 - by peak with adj size 19 1 36824771 5 - by peak with adj size 9590252 rat Scort12 Serum corticosterone level QTL 12 20 20.46 0.001 9.7 40318 D20Rat60 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 20 1 39737376 5 - by peak with adj size 20 1 37105774 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 37550487 5 - by peak with adj size 20 1 36600972 5 - by peak with adj size 9590268 rat Scort13 Serum corticosterone level QTL 13 10 3.26 0.001 8.5 36496 D10Rat37 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 10 12411032 57411032 5 - by peak with adj size 10 12631435 57631435 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 12639513 57639513 5 - by peak with adj size 10 11474010 56474010 5 - by peak with adj size 9590272 rat Scort14 Serum corticosterone level QTL 14 15 2.78 0.001 9.2 37308 D15Rat52 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 intercross;intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 15 16980907 61980907 5 - by peak with adj size 9590275 rat Scort15 Serum corticosterone level QTL 15 20 3.48 0.001 10.5 34280 D20Mgh4 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 20 1 30410692 5 - by peak with adj size 20 1 29380417 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 28375393 5 - by peak with adj size 20 1 29191651 5 - by peak with adj size 9590286 rat Uminl1 Urine mineral level QTL 1 3 3.5 0.001 9.4 37032 D3Rat66 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) abnormal urine homeostasis Water-Electrolyte Imbalance 8694157 25003539 3 36313853 81313853 5 - by peak with adj size 3 25533304 70533304 5 - by peak with adj size intercross;intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 3 29682732 74682732 5 - by peak with adj size 3 28249687 73249687 5 - by peak with adj size 9590290 rat Uminl2 Urine mineral level QTL 2 6 3.96 0.001 11.3 35583 D6Rat50 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) abnormal urine homeostasis Water-Electrolyte Imbalance 8694157 25003539 6 51267831 96267831 5 - by peak with adj size 6 41096237 86096237 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 41679046 86679046 5 - by peak with adj size 6 38783989 83783989 5 - by peak with adj size 9590292 rat Uminl3 Urine mineral level QTL 3 8 3.62 0.001 8.2 35038 D8Rat16 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) abnormal urine homeostasis Water-Electrolyte Imbalance 8694157 25003539 8 78280970 123280970 5 - by peak with adj size 8 76378702 121378702 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 8 78805083 123805083 5 - by peak with adj size 8 71888757 116888757 5 - by peak with adj size 9590294 rat Uminl4 Urine mineral level QTL 4 14 5.66 0.001 10.9 40134 D14Rat91 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) abnormal urine homeostasis Water-Electrolyte Imbalance 8694157 25003539 14 61668643 106668643 5 - by peak with adj size 14 61376259 106376259 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 14 60980905 105980905 5 - by peak with adj size 14 55624247 100624247 5 - by peak with adj size 9590298 rat Uminl5 Urine mineral level QTL 5 19 3.59 0.001 6.4 35959 D19Rat15 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) abnormal urine homeostasis Water-Electrolyte Imbalance 8694157 25003539 19 4307913 49307913 5 - by peak with adj size 19 1 37926274 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 1 38221845 5 - by peak with adj size 19 1 36824771 5 - by peak with adj size 9590300 rat Scort16 Serum corticosterone level QTL 16 1 4.39 0.001 13.7 37428 D1Rat200 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 1 111660137 156660137 5 - by peak with adj size 1 104439122 149439122 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 1 110620749 155620749 5 - by peak with adj size 1 103111621 148111621 5 - by peak with adj size 9590304 rat Scort17 Serum corticosterone level QTL 17 4 4.96 0.001 10.8 41102 D4Rat151 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 9590306 rat Scort18 Serum corticosterone level QTL 18 6 2.88 0.001 3.4 35583 D6Rat50 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 6 51267831 96267831 5 - by peak with adj size 6 41096237 86096237 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 41679046 86679046 5 - by peak with adj size 6 38783989 83783989 5 - by peak with adj size 9590310 rat Scort19 Serum corticosterone level QTL 19 10 6.3 0.001 20.2 36496 D10Rat37 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 10 12411032 57411032 5 - by peak with adj size 10 12631435 57631435 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 12639513 57639513 5 - by peak with adj size 10 11474010 56474010 5 - by peak with adj size 9590313 rat Scort20 Serum corticosterone level QTL 20 11 6.51 0.001 9.6 41428 D11Rat68 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 11 28899265 73899265 5 - by peak with adj size 11 24293499 69293499 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 11 25720038 70720038 5 - by peak with adj size 11 23280456 68280456 5 - by peak with adj size 9590316 rat Scort21 Serum corticosterone level QTL 21 17 4.75 0.001 6.2 34475 D17Mgh6 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 17 1 24771884 5 - by peak with adj size 17 1 28351208 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 1 24787908 5 - by peak with adj size 17 1 22871563 5 - by peak with adj size 9590318 rat Scort22 Serum corticosterone level QTL 22 18 7.64 0.001 26.3 37738 D18Rat57 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level lipid metabolism disorder 8694157 25003539 18 30600568 75600568 5 - by peak with adj size 18 32105822 77105822 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 18 31361341 76361341 5 - by peak with adj size 18 29792965 74792965 5 - by peak with adj size 9685065 rat Swd6 Spike wave discharge measurement QTL 6 2 5.8 0.01 9685045 rs65697820 9685054 rs105606024 9685048 rs105751187 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge rate (CMO:0001739) abnormal kindling response epilepsy;neurodegenerative disease 7794751 23903052 2 58081307 67772387 1 - by flanking markers 2 38950746 48784475 1 - by flanking markers 1302612 LEXF10C/Stm 2 38990848 49401197 1 - by flanking markers 2 39223937 48793699 1 - by flanking markers 9685068 rat Swd7 Spike wave discharge measurement QTL 7 2 3.2 0.01 9685055 rs105301743 9685056 rs106578723 9685058 rs105660993 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge rate (CMO:0001739) abnormal kindling response epilepsy;neurodegenerative disease 7794751 23903052 2 166990525 173061969 1 - by flanking markers 2 146719424 152898749 1 - by flanking markers 1302612 LEXF10C/Stm 2 147582596 153667782 1 - by flanking markers 2 141656606 147588984 1 - by flanking markers 9685799 rat Bp375 Blood pressure QTL 375 1 37428 D1Rat200 9685770 D1Mco136 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 9685377 25231251 Bp313 (sub_region) 1 134116233 179116233 4 - by one flank marker only 1 126938969 171938969 4 - by one flank marker only 9685793 SS.LEW-(D1Rat200-D1Mco136)/Bj 1 133076978 178076978 4 - by one flank marker only 1 125611501 170611501 4 - by one flank marker only 9685802 rat Bp376 Blood pressure QTL 376 1 1627193 D1Mco55 2292719 D1Mco101 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 9685377 25231251 Bp313 (sub_region) 1 135124726 180124726 4 - by one flank marker only 1 127933558 172933558 4 - by one flank marker only 9685795 SS.LEW-(D1Mco55-D1Wox6)/Bj 1 134089429 179089429 4 - by one flank marker only 1 126540680 171540680 4 - by one flank marker only 10043136 rat Iddm54 Insulin dependent diabetes mellitus QTL 54 2 3.4 1.0E-4 34005 D2Mit8 42110 D2Arb16 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140);blood glucose level (CMO:0000046) increased circulating glucose level;increased urine glucose level type 1 diabetes mellitus 10043114 24920533 2902;620562;735138;1311453 Il6r;Il12a;Tlr2;Cd101 2 169047256 225003755 1 - by flanking markers 2 148790600 198312656 1 - by flanking markers intercross 10043124 BBDP.ACI-(D2Mit8-D2Arb16)/Sunn 2 149614466 205573168 1 - by flanking markers 2 143657411 190602963 1 - by flanking markers 10043139 rat Iddm55 Insulin dependent diabetes mellitus QTL 55 2 3.1 1.0E-4 42110 D2Arb16 36773 D2Rat50 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140);blood glucose level (CMO:0000046) increased circulating glucose level;increased urine glucose level type 1 diabetes mellitus 10043114 24920533 1307992 Ptpn22 2 225003539 227035367 1 - by flanking markers 2 198312439 200390471 1 - by flanking markers intercross 10043129 BBDP.ACI-(D2Arb16-D2Rat63)/Sunn 2 205572952 207612467 1 - by flanking markers 2 190602746 192625452 1 - by flanking markers 10053700 rat Scort23 Serum corticosterone level QTL 23 1 2.69 0.0024 9.4 38230 D1Rat234 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 1 18725123 63725123 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 10053715 rat Scort24 Serum corticosterone level QTL 24 1 2.13 0.0088 7.5 34971 D1Rat81 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 1 249745300 290094216 5 - by peak with adj size 1 227619770 267910886 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 1 242302911 282763074 5 - by peak with adj size 1 221414816 260522016 5 - by peak with adj size 10053718 rat Scort25 Serum corticosterone level QTL 25 4 2.15 0.0097 8.6 38580 D4Rat140 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 4 221039059 248343840 5 - by peak with adj size 4 160240989 187126005 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 4 156855449 184226339 5 - by peak with adj size 4 155561574 182687754 5 - by peak with adj size 10053720 rat Scort26 Serum corticosterone level QTL 26 5 2.06 0.0147 10.7 37864 D5Rat93 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 Thshl2 (maps to same region) 5 134847078 177180328 5 - by peak with adj size 5 131514023 173096209 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 5 131077716 173707219 5 - by peak with adj size 5 124965598 166875058 5 - by peak with adj size 10053722 rat Scort27 Serum corticosterone level QTL 27 7 2.41 0.0083 14.7 39480 D7Rat165 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 Anxrr4 (maps to same region);Anxrr8 (maps to same region) 7 50968794 95968794 5 - by peak with adj size 7 47475514 92475514 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 7 50793818 95793818 5 - by peak with adj size 7 43228750 88228750 5 - by peak with adj size 10054088 rat Scort28 Serum corticosterone level QTL 28 17 2.04 0.0102 7.2 34827 D17Rat12 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 17 7105265 52105265 5 - by peak with adj size 17 10777341 55777341 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 17 5191047 50191047 5 - by peak with adj size 17 4528038 49528038 5 - by peak with adj size 10054123 rat Srcrt6 Stress Responsive Cort QTL 6 6 2.5 0.0043 11.4 38130 D6Rat66 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 Anxrr5 (maps to same region);Srcrt4 (maps to same region);Thshl1 (maps to same region) 6 98908944 143908944 5 - by peak with adj size 6 89772109 134772109 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 6 89631358 134631358 5 - by peak with adj size 6 85140138 130140138 5 - by peak with adj size 10054125 rat Srcrt7 Stress Responsive Cort QTL 7 9 3.33 0.0011 15.3 35691 D9Rat5 39246 D9Rat63 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 9 695542 93171004 2 - by one flank and peak markers 9 1 85187066 2 - by one flank and peak markers intercross 2292168 8655639 ISIAH WAG/Nov 9 1055222 93442944 2 - by one flank and peak markers 9 1 87073594 2 - by one flank and peak markers 10054130 rat Srcrt8 Stress Responsive Cort QTL 8 15 2.18 0.0085 7.8 39490 D15Rat112 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 Anxrr23 (maps to same region) 15 32439180 77439180 5 - by peak with adj size 15 27415941 72415941 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 15 28709741 73709741 5 - by peak with adj size 15 22117933 67117933 5 - by peak with adj size 10054132 rat Srcrt9 Stress Responsive Cort QTL 9 19 2.87 0.0017 10.6 37706 D19Rat28 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal circulating corticosterone level Stress-Induced Hypertension 10053640 21029000 19 1 27630407 5 - by peak with adj size 19 1 27535249 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 19 1 27635288 5 - by peak with adj size 19 1 27355345 5 - by peak with adj size 10054135 rat Gmadr2 Adrenal mass QTL 2 1 1.97 0.0129 10.0 35569 D1Rat30 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland weight Stress-Induced Hypertension 10053640 21029000 1 84549878 129549878 5 - by peak with adj size 1 78040182 123040182 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 1 83502376 128502376 5 - by peak with adj size 1 77857876 122857876 5 - by peak with adj size 10054138 rat Gmadr3 Adrenal mass QTL 3 6 3.68 4.5E-4 16.8 38130 D6Rat66 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland weight Stress-Induced Hypertension 10053640 21029000 6 98908944 143908944 5 - by peak with adj size 6 89772109 134772109 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 6 89631358 134631358 5 - by peak with adj size 6 85140138 130140138 5 - by peak with adj size 10054141 rat Gmadr4 Adrenal mass QTL 4 9 2.45 0.0074 9.6 37634 D9Rat79 35695 D9Rat44 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland weight Stress-Induced Hypertension 10053640 21029000 9 1 15427460 2 - by one flank and peak markers 9 1 9405916 2 - by one flank and peak markers intercross 2292168 8655639 ISIAH WAG/Nov 9 1 16520166 2 - by one flank and peak markers 9 1 14209783 2 - by one flank and peak markers 10058949 rat Gmadr5 Adrenal mass QTL 5 9 2.0 0.014 8.2 39246 D9Rat63 36147 D9Rat15 adrenal gland mass (VT:0010420) both adrenal glands wet weight to body weight ratio (CMO:0002411) abnormal adrenal gland weight Stress-Induced Hypertension 10053640 21029000 9 46933155 96842633 2 - by one flank and peak markers 9 39691557 85578105 2 - by one flank and peak markers intercross 2292168 8655639 ISIAH WAG/Nov 9 47248965 94124663 2 - by one flank and peak markers 9 42791513 87976209 2 - by one flank and peak markers 10058952 rat Gmadr6 Adrenal mass QTL 6 11 2.29 0.0072 8.6 36095 D11Rat7 adrenal gland mass (VT:0010420) both adrenal glands wet weight to body weight ratio (CMO:0002411) abnormal adrenal gland weight Stress-Induced Hypertension 10053640 21029000 11 28582457 73582457 5 - by peak with adj size 11 24000021 69000021 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 11 25401129 70401129 5 - by peak with adj size 11 22959403 67959403 5 - by peak with adj size 10058954 rat Gmadr7 Adrenal mass QTL 7 11 2.49 0.0049 10.2 37512 D11Rat50 adrenal gland mass (VT:0010420) both adrenal glands wet weight to body weight ratio (CMO:0002411) abnormal adrenal gland weight Stress-Induced Hypertension 10053640 21029000 11 67587455 93518069 5 - by peak with adj size 11 62341087 87759784 5 - by peak with adj size intercross;intercross 2292168 8655639 ISIAH WAG/Nov 11 64494671 90463843 5 - by peak with adj size 11 60346590 86241447 5 - by peak with adj size 10059587 rat Bw173 Body weight QTL 173 1 3.23 0.025 16.4 36960 D1Rat76 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Stress-Induced Hypertension 10053637 23302051 1 229743799 274743799 5 - by peak with adj size 1 207911272 252911272 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 1 222492538 267492538 5 - by peak with adj size 1 202069611 247069611 5 - by peak with adj size 10059590 rat Kidm44 Kidney mass QTL 44 1 3.42 0.025 15.3 35551 D1Rat117 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight Stress-Induced Hypertension 10045846;10053637 25707311;23302051 1 218104447 263104447 5 - by peak with adj size 1 197129821 242129821 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 1 210990171 255990171 5 - by peak with adj size 1 191033875 236033875 5 - by peak with adj size 10059592 rat Kidm45 Kidney mass QTL 45 7 3.95 0.025 17.8 41542 D7Rat150 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight Stress-Induced Hypertension 10045846;10053637 25707311;23302051 7 14498033 59498033 5 - by peak with adj size 7 10139574 55139574 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 7 14445685 59445685 5 - by peak with adj size 7 7573985 52573985 5 - by peak with adj size 10059594 rat Kidm46 Kidney mass QTL 46 12 3.79 0.025 15.9 41626 D12Rat93 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight Stress-Induced Hypertension 10045846;10053637 25707311;23302051 12 11702350 54450796 5 - by peak with adj size 12 7175941 46782294 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 12 9789834 52716770 5 - by peak with adj size 12 6107579 46669029 5 - by peak with adj size 10059597 rat Bp377 Blood pressure QTL 377 1 3.42 0.025 16.9 38854 D1Rat168 37598 D1Rat176 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased left ventricle systolic pressure Stress-Induced Hypertension 10053637 23302051 1 36777497 224224750 1 - by flanking markers intercross 2292168 8655639 ISIAH WAG/Nov 1 35377692 217372257 1 - by flanking markers 1 32737458 199368955 1 - by flanking markers 10059600 rat Bp378 Blood pressure QTL 378 1 3.08 0.05 15.0 38854 D1Rat168 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased left ventricle systolic pressure Stress-Induced Hypertension 10053637 23302051 1 201724855 246724855 5 - by peak with adj size 1 182122023 227122023 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 1 194872362 239872362 5 - by peak with adj size 1 176869060 221869060 5 - by peak with adj size 10059603 rat Bw174 Body weight QTL 174 X 3.4 0.025 16.4 41530 DXRat104 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Stress-Induced Hypertension 10053637 23302051 X 118749502 154597545 5 - by peak with adj size X 120948685 160699376 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov X 118715462 159970021 5 - by peak with adj size X 113937816 152453651 5 - by peak with adj size 10059605 rat Kidm47 Kidney mass QTL 47 7 2.91 0.05 12.5 37236 D7Rat51 39480 D7Rat165 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight Stress-Induced Hypertension 10045846;10053637 25707311;23302051 1305922 Ptprb 7 54558231 73468910 1 - by flanking markers 7 50833677 69975631 1 - by flanking markers intercross 2292168 8655639 ISIAH WAG/Nov 7 54534996 73293934 1 - by flanking markers 7 47251783 65728867 1 - by flanking markers 10401796 rat Kidm48 Kidney mass QTL 48 4 36486 D4Rat68 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) decreased kidney weight Stress-Induced Hypertension 10045846 25707311 62068;1307911 Ptpro;Wbp11 4 210767051 248343840 5 - by peak with adj size 4 149669560 187126005 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 4 146497452 184226339 5 - by peak with adj size 4 145568712 182687754 5 - by peak with adj size 10401800 rat Kidm49 Kidney mass QTL 49 6 39848 D6Rat143 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) decreased kidney weight Stress-Induced Hypertension 10045846 25707311 628688;1305798 Pdia6;Mboat2 6 25574977 70574977 5 - by peak with adj size 6 15204061 60204061 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 6 16810107 61810107 5 - by peak with adj size 6 14368788 59368788 5 - by peak with adj size 10401803 rat Kidm50 Kidney mass QTL 50 10 35001 D10Rat43 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) decreased kidney weight Stress-Induced Hypertension 10045846 25707311 628651;1308329 Gm2a;Wwc1 10 1 44766832 5 - by peak with adj size 10 928203 45928203 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 10 1 44902893 5 - by peak with adj size 10 418344 45418344 5 - by peak with adj size 10401805 rat Kidm51 Kidney mass QTL 51 15 41564 D15Rat80 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) decreased kidney weight Stress-Induced Hypertension 10045846 25707311 708573;1308430 Cadps;C15h14orf119 15 7809441 52809441 5 - by peak with adj size 15 3006380 48006380 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 15 3881131 48881131 5 - by peak with adj size 15 306329 45306329 5 - by peak with adj size 10401807 rat Kidm52 Kidney mass QTL 52 17 40956 D17Rat107 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) decreased kidney weight Stress-Induced Hypertension 10045846 25707311 727792;1359256;7641943 Isca1;Kiaa1191;LOC102550987 17 1 34339346 5 - by peak with adj size 17 1 37745437 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 17 1 32230361 5 - by peak with adj size 17 1 31701463 5 - by peak with adj size 10401810 rat Kidm53 Kidney mass QTL 53 3 35981 D3Rat56 39050 D3Rat130 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight Stress-Induced Hypertension 10045846 25707311 1303272 Mmadhc 3 2612834 55227748 1 - by flanking markers 3 3577905 44551542 1 - by flanking markers intercross 2292168 8655639 ISIAH WAG/Nov 3 2631421 48562146 1 - by flanking markers 3 8227194 47233430 1 - by flanking markers 10401812 rat Kidm54 Kidney mass QTL 54 6 39848 D6Rat143 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) decreased kidney weight Stress-Induced Hypertension 10045846 25707311 628688;1305798 Pdia6;Mboat2 6 25574977 70574977 5 - by peak with adj size 6 15204061 60204061 5 - by peak with adj size intercross 2292168 8655639 ISIAH WAG/Nov 6 16810107 61810107 5 - by peak with adj size 6 14368788 59368788 5 - by peak with adj size 10402051 rat Gdil2 Gastrointestinal dilation QTL 2 2 39834 D2Rat252 35643 D2Rat21 34278 D2Mgh14 enteric ganglion morphology trait (VT:0001045) length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836) aganglionic megacolon Hirschsprung's disease;Total Intestinal Aganglionosis 10402048 25790447 2677;628641;1306690 Gdnf;Ptger4;Slc45a2 additive 2 42461221 95410202 1 - by flanking markers 2 23966484 75806439 1 - by flanking markers 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 2 23280647 75687607 1 - by flanking markers 2 24903853 74786777 1 - by flanking markers 10402855 rat Bp379 Blood pressure QTL 379 7 0.21 36691 D7Rat27 34395 D7Mgh1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 7 35931747 80931747 4 - by one flank marker only 7 32004504 77004504 4 - by one flank marker only 10402834 LEW.SS-(D7Rat27-D7Mgh1)/Ayd 7 35867729 80867729 4 - by one flank marker only 7 29409683 74409683 4 - by one flank marker only 10402857 rat Bp380 Blood pressure QTL 380 8 0.95 2301438 D8Chm12 35018 D8Rat15 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 10402836 LEW.SS-(D8Chm12-D8Rat15)/Ayd 8 61394378 106394378 4 - by one flank marker only 8 53968765 98968765 4 - by one flank marker only 10402859 rat Bp381 Blood pressure QTL 381 10 0.002 5035717 D10Chm4 1578891 D10Chm29 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 10 30002634 75002634 4 - by one flank marker only 10 31098661 76098661 4 - by one flank marker only 10402839 LEW.SS-(D10Mgh6-D10Mgh1)/Ayd 10 30099909 75099909 4 - by one flank marker only 10 27606468 72606468 4 - by one flank marker only 10450493 rat Bp382 Blood pressure QTL 382 10 0.002 1579093 D10Chm14 10402890 D10Chm276 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 10 97793396 112200500 4 - by one flank marker only 10 99233734 110718848 4 - by one flank marker only 10402839 LEW.SS-(D10Mgh6-D10Mgh1)/Ayd 10 98079221 112626471 4 - by one flank marker only 10 94759759 107211142 4 - by one flank marker only 10450495 rat Bp383 Blood pressure QTL 383 10 0.002 44781 D10Got112 1579130 D10Chm154 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 10 78816241 97996556 1 - by flanking markers 10 79857808 99440638 1 - by flanking markers 10402839 LEW.SS-(D10Mgh6-D10Mgh1)/Ayd 10 78970279 98282519 1 - by flanking markers 10 76246085 94965338 1 - by flanking markers 10450498 rat Bp384 Blood pressure QTL 384 10 0.002 1578931 D10Chm171 10402898 D10Chm280 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 10 69797667 112200500 4 - by one flank marker only 10 71032534 110718848 4 - by one flank marker only 10402839 LEW.SS-(D10Mgh6-D10Mgh1)/Ayd 10 70166960 112626471 4 - by one flank marker only 10 67750049 107211142 4 - by one flank marker only 10450500 rat Bp385 Blood pressure QTL 385 10 0.002 1578839 D10Chm79 1579166 D10Chm3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 10 73626664 75641342 1 - by flanking markers 10 74524802 75428239 1 - by flanking markers 10402839 LEW.SS-(D10Mgh6-D10Mgh1)/Ayd 10 73727917 74459500 1 - by flanking markers 10 71115217 71966743 1 - by flanking markers 10450503 rat Bp386 Blood pressure QTL 386 17 0.28 36225 D17Rat15 37234 D17Rat97 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 10402053 25963546 17 33949701 60264322 1 - by flanking markers 17 37727971 73041350 1 - by flanking markers 10402842 LEW.SS-(D17Rat15-D17Rat51)/Ayd 17 32055882 58468016 1 - by flanking markers 17 31368391 62109574 1 - by flanking markers 10450794 rat Scl69 Serum cholesterol level QTL 69 3 6.3 0.001 56.0 36167 D3Rat50 60387 D3Got19 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 3 26468864 30463421 1 - by flanking markers 3 16685411 20828959 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 21223803 66223803 4 - by one flank marker only 3 20714090 65714090 4 - by one flank marker only 10450804 rat Scl70 Serum cholesterol level QTL 70 3 4.7 0.001 59.0 36167 D3Rat50 60387 D3Got19 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 3 26468864 30463421 1 - by flanking markers 3 16685411 20828959 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 21223803 66223803 4 - by one flank marker only 3 20714090 65714090 4 - by one flank marker only 10450806 rat Scl71 Serum cholesterol level QTL 71 3 5.8 0.001 39.0 60385 D3Got175 37010 D3Rat49 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 3 29989957 33340453 1 - by flanking markers 3 20341140 23762628 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 24772984 28136884 1 - by flanking markers 3 24192455 27494778 1 - by flanking markers 10450808 rat Scl72 Serum cholesterol level QTL 72 3 4.4 0.001 41.0 60385 D3Got175 37010 D3Rat49 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 3 29989957 33340453 1 - by flanking markers 3 20341140 23762628 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 24772984 28136884 1 - by flanking markers 3 24192455 27494778 1 - by flanking markers 10450811 rat Scl73 Serum cholesterol level QTL 73 3 4.7 0.001 67.0 60385 D3Got175 37010 D3Rat49 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 3 29989957 33340453 1 - by flanking markers 3 20341140 23762628 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 24772984 28136884 1 - by flanking markers 3 24192455 27494778 1 - by flanking markers 10450813 rat Scl74 Serum cholesterol level QTL 74 3 5.8 0.001 19.0 37510 D3Rat100 37032 D3Rat66 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 3 44344790 58813913 1 - by flanking markers 3 35237920 48033364 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 39248391 52182792 1 - by flanking markers 3 38192233 50749747 1 - by flanking markers 10450816 rat Scl75 Serum cholesterol level QTL 75 3 4.4 0.001 12.0 37510 D3Rat100 37032 D3Rat66 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 3 44344790 58813913 1 - by flanking markers 3 35237920 48033364 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 39248391 52182792 1 - by flanking markers 3 38192233 50749747 1 - by flanking markers 10450818 rat Scl76 Serum cholesterol level QTL 76 4 3.6 0.01 60.0 39980 D4Rat156 33757 D4Mit2 blood VLDL cholesterol amount (VT:0005144) blood high density lipoprotein cholesterol level (CMO:0000052) increased circulating VLDL cholesterol level atherosclerosis 10402111 25296178 4 47489708 55539285 1 - by flanking markers 4 46657899 55370202 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 4 47685694 55791834 1 - by flanking markers 4 49178116 57114705 1 - by flanking markers 10450821 rat Scl77 Serum cholesterol level QTL 77 4 4.1 0.01 61.0 39980 D4Rat156 33757 D4Mit2 blood VLDL cholesterol amount (VT:0005144) blood high density lipoprotein cholesterol level (CMO:0000052) increased circulating VLDL cholesterol level atherosclerosis 10402111 25296178 4 47489708 55539285 1 - by flanking markers 4 46657899 55370202 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 4 47685694 55791834 1 - by flanking markers 4 49178116 57114705 1 - by flanking markers 10450825 rat Scl78 Serum cholesterol level QTL 78 4 3.7 0.01 64.0 39980 D4Rat156 33757 D4Mit2 blood VLDL cholesterol amount (VT:0005144) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating VLDL cholesterol level atherosclerosis 10402111 25296178 4 47489708 55539285 1 - by flanking markers 4 46657899 55370202 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 4 47685694 55791834 1 - by flanking markers 4 49178116 57114705 1 - by flanking markers 10450828 rat Scl79 Serum cholesterol level QTL 79 7 3.5 0.001 51.0 36442 D7Rat20 36661 D7Rat15 blood HDL cholesterol amount (VT:0000184) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating HDL cholesterol level atherosclerosis 10402111 25296178 7 98803655 110975995 1 - by flanking markers 7 95054499 107428439 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 7 98200188 111043530 1 - by flanking markers 7 89867376 101773158 1 - by flanking markers 10450831 rat Scl80 Serum cholesterol level QTL 80 11 4.7 0.01 63.0 5507707 SST-112F 38800 D11Rat43 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) increased circulating LDL cholesterol level atherosclerosis 10402111 25296178 11 80374597 90292014 1 - by flanking markers 11 79125177 85040103 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 11 80358408 87200449 1 - by flanking markers 11 76957131 83051965 1 - by flanking markers 10450852 rat Stl33 Serum triglyceride level QTL 33 3 3.4 0.05 5.0 37510 D3Rat100 37032 D3Rat66 blood LDL triglyceride amount (VT:0010699) blood lipoprotein triglyceride level (CMO:0002685) increased circulating triglyceride level atherosclerosis 10402111 25296178 3 44344790 58813913 1 - by flanking markers 3 35237920 48033364 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 3 39248391 52182792 1 - by flanking markers 3 38192233 50749747 1 - by flanking markers 10450854 rat Stl34 Serum triglyceride level QTL 34 12 3.5 0.05 53.0 10878 D12Wox9 44966 D12Got42 blood LDL triglyceride amount (VT:0010699) blood lipoprotein triglyceride level (CMO:0002685) increased circulating triglyceride level atherosclerosis 10402111 25296178 12 20239828 24861467 1 - by flanking markers 12 16601685 20718374 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 12 1 22853017 4 - by one flank marker only 10450856 rat Livw4 Liver weight QTL 4 7 3.8 28.0 42833 D7Rat206 60579 D7Got52 liver mass (VT:0003402) liver weight (CMO:0000092) increased liver weight atherosclerosis 10402111 25296178 7 78786126 80323758 1 - by flanking markers 7 75357125 77004148 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 7 78758303 80297776 1 - by flanking markers 7 70840118 72474897 1 - by flanking markers 10450862 rat Kidm55 Kidney mass QTL 55 7 4.9 36.0 42833 D7Rat206 60579 D7Got52 kidney mass (VT:0002707) kidney weight (CMO:0000081) increased kidney weight atherosclerosis 10402111 25296178 7 78786126 80323758 1 - by flanking markers 7 75357125 77004148 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 7 78758303 80297776 1 - by flanking markers 7 70840118 72474897 1 - by flanking markers 10450865 rat Bw175 Body weight QTL 175 8 4.1 11.0 35248 D8Rat26 42225 D8Arb13 total fat pad mass (VT:0015008) adipose tissue molecular composition measurement (CMO:0000484) increased white adipose tissue amount atherosclerosis 10402111 25296178 8 81033145 90659889 1 - by flanking markers 8 79347527 88679394 1 - by flanking markers 61106 2307121 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 8 81413898 91140553 1 - by flanking markers 8 75311777 84531599 1 - by flanking markers 10755430 rat Coatc6 Coat color QTL 6 2 0.02576 5.0 37520 D2Rat116 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 additive 2 29691473 74691473 5 - by peak with adj size 2 11345559 56345559 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 2 10555275 55555275 5 - by peak with adj size 2 11591100 56591100 5 - by peak with adj size 10755434 rat Coatc7 Coat color QTL 7 2 0.04794 4.0 36356 D2Mit33 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 additive 2 50306076 95306076 5 - by peak with adj size 2 30658883 75658883 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 2 31272379 76272379 5 - by peak with adj size 2 30648065 75648065 5 - by peak with adj size 10755436 rat Coatc8 Coat color QTL 8 2 0.02431 5.0 42573 D2Rat385 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 additive 2 56617887 101617887 5 - by peak with adj size 2 35535310 80535310 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 2 35133202 80133202 5 - by peak with adj size 2 35023117 80023117 5 - by peak with adj size 10755438 rat Coatc9 Coat color QTL 9 7 0.0 18.0 34880 D7Rat31 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 recessive 7 9838760 54838760 5 - by peak with adj size 7 5988504 50988504 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 7 9758045 54758045 5 - by peak with adj size 7 3529280 48529280 5 - by peak with adj size 10755440 rat Coatc10 Coat color QTL 10 7 0.0 26.0 44237 D7Got23 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 recessive Coatc15 (interacts with);Ednrbm1_m (maps to syntenic region) 7 14014424 59014424 5 - by peak with adj size 7 10061171 55061171 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 7 13952179 58952179 5 - by peak with adj size 7 7496499 52496499 5 - by peak with adj size 10755451 rat Coatc11 Coat color QTL 11 7 0.0 26.0 60572 D7Got36 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 recessive Coatc16 (interacts with) 7 24746760 69746760 5 - by peak with adj size 7 21220269 66220269 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 7 24731465 69731465 5 - by peak with adj size 7 17944357 62944357 5 - by peak with adj size 10755453 rat Coatc12 Coat color QTL 12 7 0.0 21.0 38794 D7Rat73 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 recessive 7 38545036 83545036 5 - by peak with adj size 7 34826390 79826390 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 7 38547706 83547706 5 - by peak with adj size 7 31112832 76112832 5 - by peak with adj size 10755455 rat Coatc13 Coat color QTL 13 7 0.0 15.0 41144 D7Rat143 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 recessive Coatc16 (interacts with) 13 82676819 118718031 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 13 77694986 114033958 5 - by peak with adj size X 4406000 49406000 5 - by peak with adj size 10755457 rat Coatc14 Coat color QTL 14 12 0.01759 5.0 35523 D12Rat58 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 additive 12 1 23022890 5 - by peak with adj size 12 1 26791827 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 12 1 23035872 5 - by peak with adj size 12 1 22591684 5 - by peak with adj size 10755459 rat Coatc15 Coat color QTL 15 14 0.01681 5.0 11030 D14Mit4 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 additive Coatc10 (interacts with) 14 21276795 66276795 5 - by peak with adj size 14 22520291 67520291 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 14 21457565 66457565 5 - by peak with adj size 14 19836944 64836944 5 - by peak with adj size 10755461 rat Coatc16 Coat color QTL 16 3 37204 D3Rat78 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation pigmentation disease 10755346 26796131 Coatc11 (interacts with);Coatc13 (interacts with) 3 136684633 181684633 5 - by peak with adj size 3 124330762 169330762 5 - by peak with adj size intercross 6480218 6480220 AR-Ednrbsl/Hkv LEH/Hkv 3 130006659 175006659 5 - by peak with adj size 3 122438700 167438700 5 - by peak with adj size 10755495 rat Bp387 Blood pressure QTL 387 13 3.78 13.0 10755478 rs105290310 10755481 rs107403307 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 10755344 22912817 recessive BP5_H (maps to syntenic region);Bp221 (maps to same region);Bp329 (maps to same region) 13 44622528 98117534 1 - by flanking markers 13 35603300 91330875 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 13 39501300 93652524 1 - by flanking markers 13 34663461 87525369 1 - by flanking markers 10755497 rat Bp388 Blood pressure QTL 388 11 2.76 9.0 10755482 rs107338789 10755483 rs66115015 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 10755344 22912817 additive BP51_H (maps to syntenic region) 11 23121623 80995502 1 - by flanking markers 11 19938964 78447949 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 11 19475179 79734728 1 - by flanking markers 11 19456205 76331918 1 - by flanking markers 10755499 rat Bp389 Blood pressure QTL 389 2 2.61 9.0 10755484 rs105812402 10755485 rs64512962 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 10755344 22912817 recessive Bp175 (maps to same region);Bp202 (maps to same region);Bp239 (maps to same region) 2 16543933 264155674 1 - by flanking markers 2 17573311 237865985 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 16679272 245624402 1 - by flanking markers 2 18960362 228801039 1 - by flanking markers 10755501 rat Bp390 Blood pressure QTL 390 4 2.5 9.0 10755486 rs66150763 10755487 rs106553596 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 10755344 22912817 dominant BP10_H (maps to syntenic region) 4 23775236 233582846 1 - by flanking markers 4 23399842 172484918 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 4 23850384 169318094 1 - by flanking markers 4 26775591 168368347 1 - by flanking markers 10755503 rat Bp391 Blood pressure QTL 391 15 2.37 8.0 10755492 rs107545751 10755493 rs66061982 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 10755344 22912817 additive 15 27722260 50586598 1 - by flanking markers 15 22848832 42916259 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 15 23778969 46825072 1 - by flanking markers 15 20248600 37896129 1 - by flanking markers 11353947 rat Bp392 Blood pressure QTL 392 9 11354894 RNO9 (SDPR-Exon 2) 6903888 D9Mco105 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 11353859;6903249 27113531;21814219 9 54951804 99951804 4 - by one flank marker only 6903925 SS.SHR-(D9Mco72-D9Mco105)/Mco 9 12216771 57216771 4 - by one flank marker only 9 7283252 52283252 4 - by one flank marker only 11353949 rat Bp393 Blood pressure QTL 393 9 34955 D9Rat52 37724 D9Rat84 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 6903249;11353859 21814219;27113531 9 87395337 91313982 1 - by flanking markers 9 81204760 83316504 1 - by flanking markers 6903936 SS.SHR-(D9Rat7-D9Rat84)/Mco 9 46579769 91579769 4 - by one flank marker only 9 40194188 85194188 4 - by one flank marker only 11353951 rat Bp394 Blood pressure QTL 394 9 11353952 D9Mco113 11353953 D9Mco116 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 11353859 27113531 708488 Spp2 9 95118069 95906271 1 - by flanking markers 9 87225627 88154617 1 - by flanking markers 11354926 SS.SHR-(D9Mco110-D9Got111)/Bj 9 95430880 96200480 1 - by flanking markers 9 44649921 89649921 4 - by one flank marker only 11353957 rat Bmd92 Bone mineral density QTL 92 9 0.01 11353952 D9Mco113 11353958 D9Mco124 tibia mineral mass (VT:1000283) volumetric bone mineral density (CMO:0001553) abnormal tibia morphology osteoporosis 11353859 27113531 708488 Spp2 9 95118069 97361568 1 - by flanking markers 9 87225627 89709209 1 - by flanking markers 11354924 SS.SHR-(D9Mco113-D9Mco124)/Bj 9 95430880 97679852 1 - by flanking markers 9 46114199 91114199 4 - by one flank marker only 11528620 rat Bss113 Bone structure and strength QTL 113 3 9.75 1.7E-10 11528617 rs106758500 11528618 rs106987644 11528616 rs106984956 femur morphology trait (VT:0000559) femoral neck width (CMO:0001695) abnormal femur morphology 11528619 26297441 3 17570016 20527281 1 - by flanking markers 3 12200198 14999876 1 - by flanking markers 6480190 NAft:HS 3 12236221 15217668 1 - by flanking markers 3 16490648 19241681 1 - by flanking markers 11528624 rat Bss114 Bone structure and strength QTL 114 5 6.54 2.87E-7 11528622 rs197434291 11528623 rs105692231 11528621 rs198651987 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) abnormal bone strength 11528619 26297441 5 133169655 135721853 1 - by flanking markers 5 131000281 133500122 1 - by flanking markers 6480190 NAft:HS 5 129335618 131897286 1 - by flanking markers 5 124399325 126768268 1 - by flanking markers 11528628 rat Bss116 Bone structure and strength QTL 116 10 6.46 3.8E-7 11528626 rs198350962 11528627 rs105202638 11528625 rs105872339 femur morphology trait (VT:0000559) femur length (CMO:0000442) abnormal femur morphology 11528619 26297441 10 44871972 45499761 1 - by flanking markers 10 45699961 47100098 1 - by flanking markers 10 45114283 45744081 1 - by flanking markers 10 44179770 45632973 1 - by flanking markers 11528631 rat Bss117 Bone structure and strength QTL 117 10 6.41 3.89E-7 11528629 rs105809441 11528630 rs106226950 11528625 rs105872339 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) abnormal bone strength 11528619 26297441 10 46265507 46767753 1 - by flanking markers 10 46400322 46900063 1 - by flanking markers 6480190 NAft:HS 10 46510525 46995276 1 - by flanking markers 10 44947163 45433933 1 - by flanking markers 11528636 rat Bss120 Bone structure and strength QTL 120 17 8.55 2.7E-9 11528634 rs197277061 11528635 rs197861804 11528632 rs198863294 femur morphology trait (VT:0000559) femoral neck width (CMO:0001695) abnormal femur morphology 11528619 26297441 17 83682542 84358722 1 - by flanking markers 17 88999875 89799839 1 - by flanking markers 6480190 NAft:HS 17 81940459 82621764 1 - by flanking markers 17 77830064 78603788 1 - by flanking markers 11528640 rat Bss121 Bone structure and strength QTL 121 20 6.72 1.9E-7 11528638 rs197893447 11528639 rs105033786 11528637 rs105739537 femur morphology trait (VT:0000559) femur length (CMO:0000442) abnormal femur morphology 11528619 26297441 20 37033030 39603228 1 - by flanking markers 20 32600592 35400884 1 - by flanking markers 6480190 NAft:HS 20 35276651 37867728 1 - by flanking markers 20 33221477 35747124 1 - by flanking markers 11528644 rat Bss115 Bone structure and strength QTL 115 8 6.56 2.7E-7 11528642 rs198738055 11528643 rs198380959 11528641 rs197056246 femur morphology trait (VT:0000559) femur head width (CMO:0002717) abnormal femur morphology 11528619 26297441 8 86839049 87795462 1 - by flanking markers 8 84899992 85799787 1 - by flanking markers 6480190 NAft:HS 8 87295037 88257646 1 - by flanking markers 8 80802332 81664473 1 - by flanking markers 11528648 rat Bss118 Bone structure and strength QTL 118 11 6.658 2.2E-7 11528646 rs107420884 11528647 rs198448974 11528645 rs105204296 femur strength trait (VT:0010010) femur ultimate displacement (CMO:0002719) abnormal bone strength 11528619 26297441 11 45975219 48667416 1 - by flanking markers 11 41400037 44300147 1 - by flanking markers 6480190 NAft:HS 11 42784725 45474665 1 - by flanking markers 11 40638763 43376331 1 - by flanking markers 11530002 rat Bss119 Bone structure and strength QTL 119 12 16.39 4.0E-17 11529999 rs197969186 11530000 rs197046678 11529998 rs196994347 lumbar vertebra area (VT:0010570) lumbar vertebra area (CMO:0001688) abnormal lumbar vertebrae morphology 11528619 26297441 12 25918064 26391686 1 - by flanking markers 12 22000595 22501174 1 - by flanking markers 6480190 NAft:HS 12 23920656 24394383 1 - by flanking markers 12 20873419 21346740 1 - by flanking markers 11530004 rat Niddm71 Non-insulin dependent diabetes mellitus QTL 71 4 0.001 38434 D4Rat134 41102 D4Rat151 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level type 2 diabetes mellitus 11528530 27463508 1584719 Ndufa4 4 31425512 51088845 1 - by flanking markers 4 29414068 50721056 1 - by flanking markers 11 female SBN/y were inter-crossed with 3 male CDs/y rats, F1 progeny were mated brother-to-sister to produce an F2 of 166 male animals. 631573 1357191 SBN/Ygl CDS/Ygl 4 31554484 51311866 1 - by flanking markers 11530008 CDS.CDR-(D4Rat9-D4Rat153)/Ygl 4 32584199 52754138 1 - by flanking markers 11530006 rat Niddm72 Non-insulin dependent diabetes mellitus QTL 72 13 0.001 36920 D13Rat46 37554 D13Rat57 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level type 2 diabetes mellitus 11528530 27463508 13 84460970 91468484 1 - by flanking markers 13 77336098 84280390 1 - by flanking markers 11 female SBN/y were inter-crossed with 3 male CDs/y rats, F1 progeny were mated brother-to-sister to produce an F2 of 166 male animals. 631573 1357191 SBN/Ygl CDS/Ygl 13 79567081 86833540 1 - by flanking markers 11530011 CDS.SBN-(D13Rat85-D13Mit4)/Ygl 13 74023918 80753406 1 - by flanking markers 11556286 rat Cm81 Cardiac mass QTL 81 8 0.01 33559 D8Mit5 34415 D8Mgh6 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) decreased heart weight 61054 9045857 8 33603024 65467051 1 - by flanking markers 8 32203394 64762616 1 - by flanking markers F2 61106 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv 8 33558660 65717592 1 - by flanking markers 8 30848154 61290444 1 - by flanking markers 11565180 rat Kidm56 Kidney mass QTL 56 2 0.003 66535 D2Mco8 3195 Npr1 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 2 192132537 209287892 1 - by flanking markers 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd 2 172795683 189857032 1 - by flanking markers 2 152413072 175950118 1 - by flanking markers 11565181 rat Bw176 Body weight QTL 176 2 0.002 66535 D2Mco8 3195 Npr1 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight 1599557 17143582 2 192132537 209287892 1 - by flanking markers 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd 2 172795683 189857032 1 - by flanking markers 2 152413072 175950118 1 - by flanking markers 11565451 rat Bw177 Body weight QTL 177 3 0.002 728036 D3Chm60 39584 D3Rat206 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight 1599557 17143582 3 36274422 79557281 1 - by flanking markers 3 27762470 68832545 1 - by flanking markers 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd 3 31103589 72989078 1 - by flanking markers 3 31426403 70668733 1 - by flanking markers 11565452 rat Kidm57 Kidney mass QTL 57 3 0.001 728036 D3Chm60 39584 D3Rat206 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 3 36274422 79557281 1 - by flanking markers 3 27762470 68832545 1 - by flanking markers 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd 3 31103589 72989078 1 - by flanking markers 3 31426403 70668733 1 - by flanking markers 11565453 rat Kidm58 Kidney mass QTL 58 10 0.002 1578987 D10Chm229 1578931 D10Chm171 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1559293;1599557 16286573;17143582 10 68361762 69797898 1 - by flanking markers 10 69555329 71032765 1 - by flanking markers 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd 10 68697928 70167191 1 - by flanking markers 10 66319447 67750281 1 - by flanking markers 11565454 rat Kidm59 Kidney mass QTL 59 18 0.001 38430 D18Rat62 1578949 D18Chm91 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 18 7012157 15053556 1 - by flanking markers 18 6934443 12677409 1 - by flanking markers 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd 18 7057769 15274626 1 - by flanking markers 18 6791251 12205285 1 - by flanking markers 12798519 rat Anxrr54 Anxiety related response QTL 54 4 2.54 0.05 39528 D4Rat176 34493 D4Mgh27 locomotor behavior trait (VT:0001392) distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493) 11566049 27044679 4 177495398 191499474 1 - by flanking markers 4 116314137 129309017 1 - by flanking markers intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 112807675 157807675 4 - by one flank marker only 4 114627026 159627026 4 - by one flank marker only 12798520 rat Anxrr55 Anxiety related response QTL 55 4 4.45 0.01 41102 D4Rat151 39528 D4Rat176 11012 D4Wox22 locomotor behavior trait (VT:0001392) number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715) 11566049 27044679 4 29463219 177495613 1 - by flanking markers 4 29413655 116314353 1 - by flanking markers intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 29549895 112807890 1 - by flanking markers 4 32583980 114627242 1 - by flanking markers 12798523 rat Anxrr56 Anxiety related response QTL 56 4 2.83 0.05 35721 D4Rat76 34493 D4Mgh27 36043 D4Rat49 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 11566049 27044679 4 150964994 191499474 1 - by flanking markers 4 84886545 129309017 1 - by flanking markers intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 86312589 147702403 2 - by one flank and peak markers 4 85253748 150276390 2 - by one flank and peak markers 12798525 rat Anxrr57 Anxiety related response QTL 57 4 3.21 0.05 35088 D4Rat59 34338 D4Mgh11 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 11566049 27044679 4 209380165 230565226 1 - by flanking markers 4 150047799 171204531 1 - by flanking markers intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 146086918 168047091 1 - by flanking markers 4 147278504 167139601 1 - by flanking markers 12798527 rat Anxrr58 Anxiety related response QTL 58 4 4.11 0.05 34493 D4Mgh27 35088 D4Rat59 34106 D4Mgh6 locomotor behavior trait (VT:0001392) distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493) 11566049 27044679 4 191499221 209380347 1 - by flanking markers 4 129308765 150048167 1 - by flanking markers intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 120318422 146087100 2 - by one flank and peak markers 4 119463257 147278687 2 - by one flank and peak markers 12801411 rat Schws8 Schwannoma susceptibility QTL 8 6 33662 D6Mit1 42802 D6Rat229 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 11566050 25303613 2582 Esr2 6 108684958 153684958 4 - by one flank marker only 6 98840516 99750142 1 - by flanking markers 12738394 BDIX.BDIV-D6Mit8-D6Rat229/Zte 6 99273921 144273921 4 - by one flank marker only 6 94968928 139968928 4 - by one flank marker only 12801471 rat Schws9 Schwannoma susceptibility QTL 9 6 42802 D6Rat229 5503130 NGB nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 11566050 25303613 1308362 Plekhh1 6 75415502 120415502 4 - by one flank marker only 6 99749898 111234448 1 - by flanking markers 12738372 BDIX.BDIV-D6Mit1-D6Mgh2/Zte 6 66129520 111129520 4 - by one flank marker only 6 61747639 106747639 4 - by one flank marker only 12879436 rat Bp395 Blood pressure QTL 395 13 1642163 D13Hmgc84 1642161 D13Hmgc30 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12802369 23460292 3554;620287;1305646;1564395 Ren;Mybph;Chit1;Plekha6 13 55063057 56136528 1 - by flanking markers 13 46103036 47198372 1 - by flanking markers 12802362 SS.BN-(D13Rat25-RN34_13048990782)/Mcwi 13 49994708 51081193 1 - by flanking markers 13 44639182 45700190 1 - by flanking markers 12879441 rat Bp396 Blood pressure QTL 396 13 1642161 D13Hmgc30 12859029 RN34_13048990782 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12802369 23460292 621123;621137 Ptprv;Rnpep 13 56136324 101136324 4 - by one flank marker only 13 47198168 48990782 1 - by flanking markers 12802367 SS.BN-(2340-RN34_13048990782)/Mcwi 13 51080989 96080989 4 - by one flank marker only 13 45699983 90699983 4 - by one flank marker only 12879444 rat Bp397 Blood pressure QTL 397 13 36884 D13Rat25 12859027 rs198199323 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12802368 23817491 619769;620226 Fmod;Prelp 13 55314020 100314020 4 - by one flank marker only 13 46520126 91520126 4 - by one flank marker only 12802364 SS.BN-(D13Rat25-rs198199323)/Mcwi 13 50260357 50897964 1 - by flanking markers 13 45049404 45516593 1 - by flanking markers 12879471 rat Bp398 Blood pressure QTL 398 13 12879468 4110 12832756 rs106935835 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12802368 23817491 2225 Btg2 13 10971123 55971123 4 - by one flank marker only 13 47008948 92008948 4 - by one flank marker only 12802363 SS.BN-(D13Rat25-rs106935835)/Mcwi 13 50896091 50918009 1 - by flanking markers 13 45514719 45536711 1 - by flanking markers 12879472 rat Bp399 Blood pressure QTL 399 13 40688 D13Rat124 37314 D13Rat101 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12802368;12832723 23817491;21521778 13 55662705 58314767 1 - by flanking markers 13 46721037 49428577 1 - by flanking markers 6907445 SS.BN-(D13Rat124-D13Rat101)/Mcwi 13 50609228 53264877 1 - by flanking markers 13 45228358 47841255 1 - by flanking markers 12879475 rat Bp400 Blood pressure QTL 400 13 42995 D13Rat151 43003 D13Rat197 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9831392;12802369 20009007;23460292 13 71941043 87516988 1 - by flanking markers 13 64083138 80109632 1 - by flanking markers 2302984 SS.BN-(D13Rat151-D13Rat197)/Mcwi 13 66971778 111971778 4 - by one flank marker only 13 61825626 106807694 4 - by one flank marker only 12879477 rat Bp401 Blood pressure QTL 401 13 36747 D13Rat20 2324939 D13Hmgc85 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12798539 21257920 1306212;1564507 Tmem163;Nckap5 13 47267053 92267053 4 - by one flank marker only 13 38329089 83329089 4 - by one flank marker only 2293146 12798538 SS.BN-(D13Rat20-D13Got22)/Mcwi SS.BN-(D13Rat111-D13Hmgc85)/Mcwi 13 42155543 44588509 1 - by flanking markers 13 37262092 82262092 4 - by one flank marker only 12879506 rat Pur33 Proteinuria QTL 33 9 11353952 D9Mco113 11353953 D9Mco116 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 11353859 27113531 9 95118069 95906271 1 - by flanking markers 9 87225627 88154617 1 - by flanking markers A parental congenic strain was crossed with SS/Jr rats to generate an F1 population, which was intercrossed to obtain an F2 population. These rats with various introgressed regions were backcrossed to SS/Jr, sorted by genotyping and intercrossed to obtain homozygous congenic animals. 11354926 SS.SHR-(D9Mco110-D9Got111)/Bj 9 95430880 96200480 1 - by flanking markers 9 44649921 89649921 4 - by one flank marker only 12879830 rat Bw178 Body weight QTL 178 2 0.001 1358030 D2Chm33 1358052 D2Chm90 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 12879831 rat Cm82 Cardiac mass QTL 82 2 0.001 1358030 D2Chm33 1358052 D2Chm90 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 12879832 rat Cm83 Cardiac mass QTL 83 2 0.001 1358030 D2Chm33 1358052 D2Chm90 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 12879833 rat Cm84 Cardiac mass QTL 84 2 0.001 1358030 D2Chm33 1358052 D2Chm90 heart right ventricle mass (VT:0007033) heart weight to body weight ratio (CMO:0000074) abnormal heart right ventricle weight hypertension 1599557 17143582 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 12879834 rat Am1 Aortic mass QTL 1 2 0.001 1358030 D2Chm33 1358052 D2Chm90 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic mass hypertension 1599557 17143582 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 12879835 rat Kidm60 Kidney mass QTL 60 2 0.001 1358030 D2Chm33 1358052 D2Chm90 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) hypertension 1599557 17143582 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 12879836 rat Kidm61 Kidney mass QTL 61 2 0.001 66535 D2Mco8 1358039 D2Chm57 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) hypertension 1599557;1357413 17143582;15738349 2 192132537 219177325 1 - by flanking markers 2 158146823 192363025 1 - by flanking markers 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd 2 172795683 199696953 1 - by flanking markers 2 152413072 185122374 1 - by flanking markers 12879837 rat Am2 Aortic mass QTL 2 2 0.001 66535 D2Mco8 1358039 D2Chm57 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic mass hypertension 1599557;1357413 17143582;15738349 2 192132537 219177325 1 - by flanking markers 2 158146823 192363025 1 - by flanking markers 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd 2 172795683 199696953 1 - by flanking markers 2 152413072 185122374 1 - by flanking markers 12879838 rat Cm86 Cardiac mass QTL 86 2 0.002 66535 D2Mco8 1358039 D2Chm57 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557;1357413 17143582;15738349 2 192132537 219177325 1 - by flanking markers 2 158146823 192363025 1 - by flanking markers 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd 2 172795683 199696953 1 - by flanking markers 2 152413072 185122374 1 - by flanking markers 12879839 rat Cm85 Cardiac mass QTL 85 2 0.001 66535 D2Mco8 1358039 D2Chm57 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557;1357413 17143582;15738349 2 192132537 219177325 1 - by flanking markers 2 158146823 192363025 1 - by flanking markers 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd 2 172795683 199696953 1 - by flanking markers 2 152413072 185122374 1 - by flanking markers 12879840 rat Bw179 Body weight QTL 179 2 0.005 66535 D2Mco8 1358039 D2Chm57 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557;1357413 17143582;15738349 2 192132537 219177325 1 - by flanking markers 2 158146823 192363025 1 - by flanking markers 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd 2 172795683 199696953 1 - by flanking markers 2 152413072 185122374 1 - by flanking markers 12879841 rat Cm87 Cardiac mass QTL 87 2 0.026 1358052 D2Chm90 1358020 D2Chm46 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 2 46277412 167706439 1 - by flanking markers 2 147424195 152050550 1 - by flanking markers 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd 2 27161361 148295267 1 - by flanking markers 2 142323368 146786035 1 - by flanking markers 12879842 rat Cm88 Cardiac mass QTL 88 2 0.042 1358052 D2Chm90 1358020 D2Chm46 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 2 46277412 167706439 1 - by flanking markers 2 147424195 152050550 1 - by flanking markers 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd 2 27161361 148295267 1 - by flanking markers 2 142323368 146786035 1 - by flanking markers 12879843 rat Am3 Aortic mass QTL 3 2 0.016 1358052 D2Chm90 1358020 D2Chm46 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic mass hypertension 1599557 17143582 2 46277412 167706439 1 - by flanking markers 2 147424195 152050550 1 - by flanking markers 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd 2 27161361 148295267 1 - by flanking markers 2 142323368 146786035 1 - by flanking markers 12879844 rat Kidm62 Kidney mass QTL 62 2 0.001 1358052 D2Chm90 1358020 D2Chm46 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) hypertension 1599557 17143582 2 46277412 167706439 1 - by flanking markers 2 147424195 152050550 1 - by flanking markers 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd 2 27161361 148295267 1 - by flanking markers 2 142323368 146786035 1 - by flanking markers 12879845 rat Cm89 Cardiac mass QTL 89 2 0.008 66535 D2Mco8 3195 Npr1 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight 1599557 17143582 2 192132537 209287892 1 - by flanking markers 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd 2 172795683 189857032 1 - by flanking markers 2 152413072 175950118 1 - by flanking markers 12879846 rat Cm90 Cardiac mass QTL 90 2 0.011 66535 D2Mco8 3195 Npr1 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight 1599557 17143582 2 192132537 209287892 1 - by flanking markers 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd 2 172795683 189857032 1 - by flanking markers 2 152413072 175950118 1 - by flanking markers 12879847 rat Am4 Aortic mass QTL 4 2 0.001 66535 D2Mco8 3195 Npr1 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic mass 1599557 17143582 2 192132537 209287892 1 - by flanking markers 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd 2 172795683 189857032 1 - by flanking markers 2 152413072 175950118 1 - by flanking markers 12879848 rat Bw181 Body weght QTL 181 3 0.015 66475 D3Mco21 36717 D3Rat17 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight 1599557;724791 17143582;14517349 3 79183926 133513825 1 - by flanking markers 3 68499987 121619110 1 - by flanking markers 1357981 SS.LEW-(D3Mco21-D3Rat17)/Ayd 3 72672290 127023997 1 - by flanking markers 3 70348525 121056321 1 - by flanking markers 12879849 rat Bw180 Body weight QTL 180 3 0.037 10260 D3Rat52 39050 D3Rat130 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 12879850 rat Cm91 Cardiac mass QTL 91 3 0.001 10260 D3Rat52 39050 D3Rat130 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 12879851 rat Cm92 Cardiac mass QTL 92 3 0.001 10260 D3Rat52 39050 D3Rat130 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 12879852 rat Cm93 Cardiac mass QTL 93 3 0.001 10260 D3Rat52 39050 D3Rat130 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 12879853 rat Am5 Aortic mass QTL 5 3 0.001 10260 D3Rat52 39050 D3Rat130 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 12879854 rat Kidm63 Kidney mass QTL 63 3 0.001 10260 D3Rat52 39050 D3Rat130 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 12879863 rat Bp402 Blood pressure QTL 402 2 0.003 35292 D2Rat18 1579094 D2Chm277 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1599557 17143582 2 60126669 76472773 1 - by flanking markers 2 40912197 56722286 1 - by flanking markers 1579896 SS.LEW-(D2Rat18-D2Chm277)/Ayd 2 41063439 56736627 1 - by flanking markers 2 41125789 56532139 1 - by flanking markers 12879866 rat Cm94 Cardiac mass QTL 94 3 0.001 728036 D3Chm60 39584 D3Rat206 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight 1599557 17143582 3 36274422 79557281 1 - by flanking markers 3 27762470 68832545 1 - by flanking markers 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd 3 31103589 72989078 1 - by flanking markers 3 31426403 70668733 1 - by flanking markers 12879867 rat Cm95 Cardiac mass QTL 95 3 0.047 728036 D3Chm60 39584 D3Rat206 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 1599557 17143582 3 36274422 79557281 1 - by flanking markers 3 27762470 68832545 1 - by flanking markers 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd 3 31103589 72989078 1 - by flanking markers 3 31426403 70668733 1 - by flanking markers 12879868 rat Am6 Aortic mass QTL 6 3 0.001 728036 D3Chm60 39584 D3Rat206 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight 1599557 17143582 3 36274422 79557281 1 - by flanking markers 3 27762470 68832545 1 - by flanking markers 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd 3 31103589 72989078 1 - by flanking markers 3 31426403 70668733 1 - by flanking markers 12879871 rat Am7 Aortic mass QTL 7 3 0.001 35378 D3Rat61 43758 D3Wox1 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 12879872 rat Cm97 Cardiac mass QTL 97 3 0.001 35378 D3Rat61 43758 D3Wox1 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 12879873 rat Cm96 Cardiac mass QTL 96 3 0.001 35378 D3Rat61 43758 D3Wox1 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 12879874 rat Cm98 Cardiac mass QTL 98 3 0.005 35378 D3Rat61 43758 D3Wox1 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 12879875 rat Kidm64 Kidney mass QTL 64 3 0.001 35378 D3Rat61 43758 D3Wox1 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 12879876 rat Bw182 Body weight QTL 182 3 0.003 35378 D3Rat61 43758 D3Wox1 body mass (VT:0001259) body weight (CMO:0000012) 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 12879878 rat Bw183 Body weight QTL 183 8 0.001 2301434 D8Chm11 35018 D8Rat15 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 47200750 106394378 1 - by flanking markers 8 43296169 98968765 1 - by flanking markers 12879879 rat Cm99 Cardiac mass QTL 99 8 0.001 2301434 D8Chm11 35018 D8Rat15 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) abnormal heart weight hypertension 1599557 17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 47200750 106394378 1 - by flanking markers 8 43296169 98968765 1 - by flanking markers 12879880 rat Cm100 Cardiac mass QTL 100 8 0.001 2301434 D8Chm11 35018 D8Rat15 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 47200750 106394378 1 - by flanking markers 8 43296169 98968765 1 - by flanking markers 12879881 rat Cm101 Cardiac mass QTL 101 8 0.001 2301434 D8Chm11 35018 D8Rat15 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 47200750 106394378 1 - by flanking markers 8 43296169 98968765 1 - by flanking markers 12879882 rat Am8 Aortic mass QTL 8 8 0.001 2301434 D8Chm11 35018 D8Rat15 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 47200750 106394378 1 - by flanking markers 8 43296169 98968765 1 - by flanking markers 12879883 rat Kidm65 Kidney mass QTL 65 8 0.001 2301434 D8Chm11 35018 D8Rat15 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 47200750 106394378 1 - by flanking markers 8 43296169 98968765 1 - by flanking markers 12880023 rat Bw184 Body weight QTL 184 8 0.001 37290 D8Rat77 34723 D8Mgh9 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 8 2131937 47131937 4 - by one flank marker only 8 1501843 46501843 4 - by one flank marker only 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd 8 2108128 47108128 4 - by one flank marker only 8 2097640 47097640 4 - by one flank marker only 12880025 rat Cm102 Cardiac mass QTL 102 8 0.044 37290 D8Rat77 34723 D8Mgh9 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 8 2131937 47131937 4 - by one flank marker only 8 1501843 46501843 4 - by one flank marker only 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd 8 2108128 47108128 4 - by one flank marker only 8 2097640 47097640 4 - by one flank marker only 12880028 rat Cm103 Cardiac mass QTL 103 8 0.02 37290 D8Rat77 34723 D8Mgh9 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 8 2131937 47131937 4 - by one flank marker only 8 1501843 46501843 4 - by one flank marker only 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd 8 2108128 47108128 4 - by one flank marker only 8 2097640 47097640 4 - by one flank marker only 12880044 rat Am9 Aortic mass QTL 9 8 0.007 37290 D8Rat77 34723 D8Mgh9 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 8 2131937 47131937 4 - by one flank marker only 8 1501843 46501843 4 - by one flank marker only 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd 8 2108128 47108128 4 - by one flank marker only 8 2097640 47097640 4 - by one flank marker only 12880050 rat Am10 Aortic mass QTL 10 10 0.016 44776 D10Got92 2875 Igfbp4 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 10 76919480 86759484 1 - by flanking markers 10 77956239 87834315 1 - by flanking markers 724577 SS.LEW-(D10Rat27-Igfbp4)/Ayd 10 77055741 86962563 1 - by flanking markers 10 74372084 84007272 1 - by flanking markers 12880053 rat Cm104 Cardiac mass QTL 104 10 0.009 36203 D10Rat27 37996 D10Rat127 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 10 74127825 86215106 1 - by flanking markers 10 77091834 87272656 1 - by flanking markers 724577 SS.LEW-(D10Rat27-Igfbp4)/Ayd 10 75983662 86419171 1 - by flanking markers 10 73452992 83463334 1 - by flanking markers 12880055 rat Am11 Aortic mass QTL 11 10 0.004 1578983 D10Chm156 2875 Igfbp4 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight 1599557 17143582 10 86759484 98999296 1 - by flanking markers 10 87834315 100429624 1 - by flanking markers 728384 SS.LEW-(D10Rat24-Igfbp4)/Ayd 10 86962563 99303173 1 - by flanking markers 10 84007272 95933025 1 - by flanking markers 12880368 rat Bw187 Body weight QTL 187 18 0.045 37568 D18Rat55 62466 D18Uia6 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 12880370 rat Cm105 Cardiac mass QTL 105 10 0.008 1578987 D10Chm229 1578994 D10Chm147 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557;1559293 17143582;16286573 10 68361762 70215618 1 - by flanking markers 10 69555329 71447820 1 - by flanking markers 1579898 SS.LEW-(D10Chm128-D10Chm121)/Ayd 10 68697928 70581793 1 - by flanking markers 10 66319447 68164786 1 - by flanking markers 12880371 rat Cm106 Cardiac mass QTL 106 10 0.007 1578987 D10Chm229 1578994 D10Chm147 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557;1559293 17143582;16286573 10 68361762 70215618 1 - by flanking markers 10 69555329 71447820 1 - by flanking markers 1579898 SS.LEW-(D10Chm128-D10Chm121)/Ayd 10 68697928 70581793 1 - by flanking markers 10 66319447 68164786 1 - by flanking markers 12880372 rat Am12 Aortic mass QTL 12 10 0.003 1578987 D10Chm229 1578994 D10Chm147 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557;1559293 17143582;16286573 10 68361762 70215618 1 - by flanking markers 10 69555329 71447820 1 - by flanking markers 1579898 SS.LEW-(D10Chm128-D10Chm121)/Ayd 10 68697928 70581793 1 - by flanking markers 10 66319447 68164786 1 - by flanking markers 12880375 rat Kidm66 Kidney mass QTL 66 10 0.009 1578987 D10Chm229 1578994 D10Chm147 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557;1559293 17143582;16286573 10 68361762 70215618 1 - by flanking markers 10 69555329 71447820 1 - by flanking markers 1579898 SS.LEW-(D10Chm128-D10Chm121)/Ayd 10 68697928 70581793 1 - by flanking markers 10 66319447 68164786 1 - by flanking markers 12880384 rat Cm107 Cardiac mass QTL 107 0.001 37150 D10Rat204 36958 D10Rat9 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557;1559293 17143582;16286573 10 93421499 112200500 4 - by one flank marker only 10 94837236 99588446 1 - by flanking markers 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd 10 93662786 112626471 4 - by one flank marker only 10 90404397 107211142 4 - by one flank marker only 12880385 rat Cm108 Cardiac mass QTL 108 0.001 37150 D10Rat204 36958 D10Rat9 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557;1559293 17143582;16286573 10 93421499 112200500 4 - by one flank marker only 10 94837236 99588446 1 - by flanking markers 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd 10 93662786 112626471 4 - by one flank marker only 10 90404397 107211142 4 - by one flank marker only 12880395 rat Cm109 Cardiac mass QTL 109 10 0.001 37150 D10Rat204 36958 D10Rat9 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557;1559293 17143582;16286573 10 93421499 112200500 4 - by one flank marker only 10 94837236 99588446 1 - by flanking markers 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd 10 93662786 112626471 4 - by one flank marker only 10 90404397 107211142 4 - by one flank marker only 12880396 rat Am13 Aortic mass QTL 13 10 0.001 37150 D10Rat204 36958 D10Rat9 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557;1559293 17143582;16286573 10 93421499 112200500 4 - by one flank marker only 10 94837236 99588446 1 - by flanking markers 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd 10 93662786 112626471 4 - by one flank marker only 10 90404397 107211142 4 - by one flank marker only 12880398 rat Kidm67 Kidney mass QTL 67 10 0.001 37150 D10Rat204 36958 D10Rat9 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557;1559293 17143582;16286573 10 93421499 112200500 4 - by one flank marker only 10 94837236 99588446 1 - by flanking markers 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd 10 93662786 112626471 4 - by one flank marker only 10 90404397 107211142 4 - by one flank marker only 12902615 rat Bw185 Body weight QTL 185 10 0.01 1578839 D10Chm79 1578891 D10Chm29 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557;1559293 17143582;16286573 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 12903245 rat Cm110 Cardiac mass QTL 110 10 0.001 1578839 D10Chm79 1578891 D10Chm29 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557;1559293 17143582;16286573 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 12903246 rat Cm111 Cardiac mass QTL 111 10 0.001 1578839 D10Chm79 1578891 D10Chm29 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557;1559293 17143582;16286573 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 12903247 rat Cm112 Cardiac mass QTL 112 10 0.001 1578839 D10Chm79 1578891 D10Chm29 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557;1559293 17143582;16286573 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 12903248 rat Am14 Aortic mass QTL 14 10 0.001 1578839 D10Chm79 1578891 D10Chm29 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557;1559293 17143582;16286573 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 12903249 rat Kidm68 Kidney mass QTL 68 10 0.02 1578839 D10Chm79 1578891 D10Chm29 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557;1559293 17143582;16286573 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 12903252 rat Cm113 Cardiac mass QTL 113 10 0.047 1578987 D10Chm229 1578931 D10Chm171 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight 1599557;1559293 17143582;16286573 10 68361762 69797898 1 - by flanking markers 10 69555329 71032765 1 - by flanking markers 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd 10 68697928 70167191 1 - by flanking markers 10 66319447 67750281 1 - by flanking markers 12903266 rat Cm114 Cardiac mass QTL 114 10 0.02 1578987 D10Chm229 1578931 D10Chm171 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight 1599557;1559293 17143582;16286573 10 68361762 69797898 1 - by flanking markers 10 69555329 71032765 1 - by flanking markers 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd 10 68697928 70167191 1 - by flanking markers 10 66319447 67750281 1 - by flanking markers 12903269 rat Am15 Aortic mass QTL 15 10 0.042 1578987 D10Chm229 1578931 D10Chm171 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight 1599557;1559293 17143582;16286573 10 68361762 69797898 1 - by flanking markers 10 69555329 71032765 1 - by flanking markers 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd 10 68697928 70167191 1 - by flanking markers 10 66319447 67750281 1 - by flanking markers 12903278 rat Am16 Aortic mass QTL 16 16 0.019 1358042 D16Chm66 39456 D16Rat88 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 16 1534551 3405986 1 - by flanking markers 16 819369 3080748 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 3439525 1 - by flanking markers 16 832380 2995225 1 - by flanking markers 12903279 rat Cm115 Cardiac mass QTL 115 16 0.001 1358042 D16Chm66 39456 D16Rat88 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 16 1534551 3405986 1 - by flanking markers 16 819369 3080748 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 3439525 1 - by flanking markers 16 832380 2995225 1 - by flanking markers 12903281 rat Cm116 Cardiac mass QTL 116 16 0.001 1358042 D16Chm66 39456 D16Rat88 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 16 1534551 3405986 1 - by flanking markers 16 819369 3080748 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 3439525 1 - by flanking markers 16 832380 2995225 1 - by flanking markers 12903952 rat Cm117 Cardiac mass QTL 117 16 0.001 1358042 D16Chm66 39456 D16Rat88 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 16 1534551 3405986 1 - by flanking markers 16 819369 3080748 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 3439525 1 - by flanking markers 16 832380 2995225 1 - by flanking markers 12903954 rat Bw186 Body weight QTL 186 16 0.011 1358042 D16Chm66 39456 D16Rat88 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 16 1534551 3405986 1 - by flanking markers 16 819369 3080748 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 3439525 1 - by flanking markers 16 832380 2995225 1 - by flanking markers 12903955 rat Kidm69 Kidney mass QTL 69 16 0.001 33848 D16Mit2 39456 D16Rat88 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 16 1534551 4954192 1 - by flanking markers 16 819369 4304396 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 5013802 1 - by flanking markers 16 832380 4227609 1 - by flanking markers 12903978 rat Cm118 Cardiac mass QTL 118 17 0.001 38706 D17Rat84 12903975 D17Chm71 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 17 23473207 68473207 4 - by one flank marker only 17 29603712 72799224 1 - by flanking markers 1559035 SS.LEW-(D17Chm14-D17Rat181)/Ayd 17 21490950 66490950 4 - by one flank marker only 17 23653184 68653184 4 - by one flank marker only 12903979 rat Cm119 Cardiac mass QTL 119 17 0.001 38706 D17Rat84 12903975 D17Chm71 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 17 23473207 68473207 4 - by one flank marker only 17 29603712 72799224 1 - by flanking markers 1559035 SS.LEW-(D17Chm14-D17Rat181)/Ayd 17 21490950 66490950 4 - by one flank marker only 17 23653184 68653184 4 - by one flank marker only 12903980 rat Cm120 Cardiac mass QTL 120 17 0.002 38706 D17Rat84 12903975 D17Chm71 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 17 23473207 68473207 4 - by one flank marker only 17 29603712 72799224 1 - by flanking markers 1559035 SS.LEW-(D17Chm14-D17Rat181)/Ayd 17 21490950 66490950 4 - by one flank marker only 17 23653184 68653184 4 - by one flank marker only 12903981 rat Am17 Aortic mass QTL 17 17 0.001 38706 D17Rat84 12903975 D17Chm71 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 17 23473207 68473207 4 - by one flank marker only 17 29603712 72799224 1 - by flanking markers 1559035 SS.LEW-(D17Chm14-D17Rat181)/Ayd 17 21490950 66490950 4 - by one flank marker only 17 23653184 68653184 4 - by one flank marker only 12903982 rat Kidm70 Kidney mass QTL 70 17 0.001 38706 D17Rat84 1556758 D17Chm2 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 17 23473207 76483336 1 - by flanking markers 17 29603712 82248111 1 - by flanking markers 1559035 SS.LEW-(D17Chm14-D17Rat181)/Ayd 17 21490950 74823273 1 - by flanking markers 17 23653184 70974005 1 - by flanking markers 12904067 rat Cm122 Cardiac mass QTL 122 18 0.001 37568 D18Rat55 62466 D18Uia6 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 12904069 rat Cm123 Cardiac mass QTL 123 18 0.001 37568 D18Rat55 62466 D18Uia6 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 12904070 rat Cm124 Cardiac mass QTL 124 18 0.01 37568 D18Rat55 62466 D18Uia6 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 12904071 rat Am18 Aortic mass QTL 18 18 0.001 37568 D18Rat55 62466 D18Uia6 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 12904073 rat Kidm71 Kidney mass QTL 71 18 0.001 37568 D18Rat55 62466 D18Uia6 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 12904668 rat Bw188 Body weight QTL 188 18 0.03 40842 D18Rat101 1579069 D18Chm56 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 12904669 rat Cm125 Cardiac mass QTL 125 18 0.001 40842 D18Rat101 1579069 D18Chm56 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 12904670 rat Cm126 Cardiac mass QTL 126 18 0.001 40842 D18Rat101 1579069 D18Chm56 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 12904673 rat Cm127 Cardiac mass QTL 127 18 0.005 40842 D18Rat101 1579069 D18Chm56 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 12904675 rat Am19 Aortic mass QTL 19 18 0.001 40842 D18Rat101 1579069 D18Chm56 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 12904677 rat Kidm72 Kidney mass QTL 72 18 0.001 40842 D18Rat101 1579069 D18Chm56 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 12904680 rat Bw189 Body weight QTL 189 18 0.019 11462 D18Wox7 40842 D18Rat101 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight hypertension 1599557 17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 12904689 rat Cm128 Cardiac mass QTL 128 18 0.001 11462 D18Wox7 40842 D18Rat101 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 12904690 rat Cm129 Cardiac mass QTL 129 18 0.001 11462 D18Wox7 40842 D18Rat101 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight hypertension 1599557 17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 12904691 rat Cm130 Cardiac mass QTL 130 18 0.001 11462 D18Wox7 40842 D18Rat101 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight hypertension 1599557 17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 12904693 rat Am20 Aortic mass QTL 20 18 0.001 11462 D18Wox7 40842 D18Rat101 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight hypertension 1599557 17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 12904695 rat Kidm73 Kidney mass QTL 73 18 0.001 11462 D18Wox7 40842 D18Rat101 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight hypertension 1599557 17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 12904714 rat Cm131 Cardiac mass QTL 131 18 0.002 38430 D18Rat62 1578949 D18Chm91 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart left ventricle weight 1599557 17143582 18 7012157 15053556 1 - by flanking markers 18 6934443 12677409 1 - by flanking markers 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd 18 7057769 15274626 1 - by flanking markers 18 6791251 12205285 1 - by flanking markers 12904715 rat Cm132 Cardiac mass QTL 132 18 0.001 38430 D18Rat62 1578949 D18Chm91 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) abnormal heart right ventricle weight 1599557 17143582 18 7012157 15053556 1 - by flanking markers 18 6934443 12677409 1 - by flanking markers 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd 18 7057769 15274626 1 - by flanking markers 18 6791251 12205285 1 - by flanking markers 12904716 rat Am21 Aortic mass QTL 21 18 0.005 38430 D18Rat62 1578949 D18Chm91 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) abnormal aortic weight 1599557 17143582 18 7012157 15053556 1 - by flanking markers 18 6934443 12677409 1 - by flanking markers 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd 18 7057769 15274626 1 - by flanking markers 18 6791251 12205285 1 - by flanking markers 12904736 rat Cm121 Cardiac mass QTL 121 17 0.043 1556756 D17Chm9 39318 D17Rat65 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight 1599557 17143582 17 77361135 88435496 1 - by flanking markers 17 83074203 93930006 1 - by flanking markers 1559032 SS.LEW-(D17Rat65-D17Chm2)/Ayd 17 75705427 86731080 1 - by flanking markers 17 71774621 82479847 1 - by flanking markers 152023626 rat Bp403 Blood pressure QTL 403 17 3.86 13207338 rs107291522 12903258 rs105876746 152023625 rs107297991 arterial blood pressure trait (VT:2000000) 10755325 25573024 17 26499100 85282628 1 - by flanking markers 17 29903973 90920974 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 17 24556663 83549032 1 - by flanking markers 17 23930421 79524188 1 - by flanking markers 152023736 rat Bp404 Blood pressure QTL 404 17 3.78 13207338 rs107291522 12903258 rs105876746 152023625 rs107297991 arterial blood pressure trait (VT:2000000) 10755325 25573024 17 26499100 85282628 1 - by flanking markers 17 29903973 90920974 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 17 24556663 83549032 1 - by flanking markers 17 23930421 79524188 1 - by flanking markers 152023737 rat Bp405 Blood pressure QTL 405 5.06 13207338 rs107291522 12903258 rs105876746 152023625 rs107297991 arterial blood pressure trait (VT:2000000) 10755325 25573024 17 26499100 85282628 1 - by flanking markers 17 29903973 90920974 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 17 24556663 83549032 1 - by flanking markers 17 23930421 79524188 1 - by flanking markers 152023740 rat Bp406 Blood pressure QTL 406 17 6.06 13207338 rs107291522 12903258 rs105876746 7394842 rs65978719 arterial blood pressure trait (VT:2000000) 10755325 25573024 17 26499100 85282628 1 - by flanking markers 17 29903973 90920974 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 17 24556663 83549032 1 - by flanking markers 17 23930421 79524188 1 - by flanking markers 152025204 rat Hrtrt22 Heart rate QTL 22 2 5.6 152025193 rs106938352 152025198 rs13457335 152025195 rs107157688 heart pumping trait (VT:2000009) 10755325 25573024 1304701 Prmt6 2 47095406 202550257 1 - by flanking markers 2 27649780 175912348 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 2 27984517 183137887 1 - by flanking markers 2 28484589 169504100 1 - by flanking markers 152025206 rat Hrtrt23 Heart rate QTL 23 2 5.98 152025193 rs106938352 152025198 rs13457335 152025195 rs107157688 heart pumping trait (VT:2000009) 10755325 25573024 1304701 Prmt6 2 47095406 202550257 1 - by flanking markers 2 27649780 175912348 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 2 27984517 183137887 1 - by flanking markers 2 28484589 169504100 1 - by flanking markers 152025212 rat Bw190 Body weight QTL 190 1 5.7 152025209 rs105001389 152025208 rs8143500 152025211 rs106018237 body mass (VT:0001259) 10755325 25573024 1307842 Prcp 1 132036600 221739292 1 - by flanking markers 1 124825851 202010692 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 1 130995629 214825888 1 - by flanking markers 1 123556856 196963478 1 - by flanking markers 152025224 rat Bw193 Body weight QTL 193 10 6.47 152025221 rs66299363 152025223 rs107234941 152025222 rs107276651 body mass (VT:0001259) 10755325 25573024 1308056 Neurl4 10 53268079 77629211 1 - by flanking markers 10 53670113 78676498 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 10 53517046 77767884 1 - by flanking markers 10 51663405 75085664 1 - by flanking markers 152025227 rat Bw195 Body weight QTL 195 10 5.73 152025226 rs63992150 152025225 rs8143284 152025222 rs107276651 body mass (VT:0001259) 10755325 25573024 10 48407655 70707115 1 - by flanking markers 10 48470940 72005676 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 10 48619286 71083354 1 - by flanking markers 10 46989699 68663659 1 - by flanking markers 152025229 rat Scl83 Serum cholesterol level QTL 83 10 4.33 152025228 rs105745689 152025225 rs8143284 152025221 rs66299363 blood cholesterol amount (VT:0000180) 10755325 25573024 620207;620437;1308056;1563384 Prpsap2;Pigl;Neurl4;Rtn4ip1 10 36673822 70707115 1 - by flanking markers 10 36970925 72005676 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 10 36902642 71083354 1 - by flanking markers 10 35710580 68663659 1 - by flanking markers 152025232 rat Bw192 Body weight QTL 192 1 3.93 152025230 rs13455595 152025208 rs8143500 152025231 rs107564878 body mass (VT:0001259) 10755325 25573024 628763;1307842 Aqp11;Prcp 1 126291554 221739292 1 - by flanking markers 1 118784190 202010692 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 1 125182504 214825888 1 - by flanking markers 1 117917486 196963478 1 - by flanking markers 152025235 rat Bw194 Body weight QTL 194 1 4.86 152025209 rs105001389 152025234 rs8175083 152025233 rs107571159 body mass (VT:0001259) 10755325 25573024 1307842 Prcp 1 132036600 271241317 1 - by flanking markers 1 124825851 249210876 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 1 130995629 263796323 1 - by flanking markers 1 123556856 242907031 1 - by flanking markers 152025238 rat Slep14 Serum leptin concentration QTL 14 17 4.62 152025236 rs65958164 12903258 rs105876746 152025237 rs105739016 blood leptin amount (VT:0005667) 10755325 25573024 17 26749177 85282628 1 - by flanking markers 17 30176601 90920974 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 17 24811596 83549032 1 - by flanking markers 17 24184890 79524188 1 - by flanking markers 152025242 rat Bw191 Body weight QTL 191 2 3.62 152025240 rs106480153 152025239 rs106781749 152025241 rs107362207 body mass (VT:0001259) 10755325 25573024 2 57444863 146058371 1 - by flanking markers 2 38285110 126534709 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 2 38350683 126464339 1 - by flanking markers 2 38573329 122609194 1 - by flanking markers 152025245 rat Scl81 Serum cholesterol level QTL 81 2 3.49 152025239 rs106781749 152025244 rs107279445 152025243 rs66127962 blood cholesterol amount (VT:0000180) 10755325 25573024 1304701;1310353 Prmt6;Pex11b 2 146058371 240216807 1 - by flanking markers 2 126534709 215265692 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 2 126464339 222164311 1 - by flanking markers 2 122609194 206936711 1 - by flanking markers 152025249 rat Scl82 Serum cholesterol level QTL 82 1 4.77 152025246 rs107457854 152025248 rs106258197 152025247 rs65586488 blood cholesterol amount (VT:0000180) 10755325 25573024 1561121 Phldb3 1 49228578 106664608 1 - by flanking markers 1 44878370 100156400 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 1 50530054 105617690 1 - by flanking markers 1 50343510 99980958 1 - by flanking markers 152025253 rat Hrtrt24 Heart rate QTL 24 15 3.82 152025250 rs13456030 152025252 rs64527952 152025251 rs8150132 heart pumping trait (VT:2000009) 10755325 25573024 15 36958261 97698222 1 - by flanking markers 15 32491831 93739684 1 - by flanking markers 10755352 10755354 LH/MavRrrcAek LN/MavRrrcAek 15 33072420 94213672 1 - by flanking markers 15 27885774 86257085 1 - by flanking markers