# RGD-PIPELINE: ftp-file-extracts # MODULE: qtls build 2022-10-26 # GENERATED-ON: 2024/11/29 # PURPOSE: information about active Rat qtls extracted from RGD database # CONTACT: rgd.developers@mcw.edu # FORMAT: tab delimited text # NOTES: multiple values in a single column are separated by ';' # ### Apr 1 2011 RATMAP_IDs and RHDB_IDs are discontinued ### Oct 22 2012 fixed export of positional information for mouse qtls (positions on assembly build 38 were exported as positions on assembly 37) ### Oct 23 2012 fixed description of columns for human qtls ### Nov 20 2012 rat: positions on assembly map 3.1 are no longer exported; instead position on assembly 5.0 are exported ### Apr 18 2013 rat: crossed strains are reported in separate columns for easier sorting ### Jul 16 2014 mouse: added generation of file QTLS_MOUSE_B38.txt with positions on assemblies 38 and 37 ### Sep 09 2014 rat: added positions on Rnor_6.0 assembly ### Sep 09 2014 mouse: QTLS_MOUSE_B38.txt discontinued; 4 columns added to QTLS_MOUSE.txt file to accommodate assembly 38 positions ### Jan 08 2016 TRAIT_METHODOLOGY column discontinued; column #16 SUBTRAIT_NAME is now called MEASUREMENT_TYPE ### Jan 11 2016 rat: added columns STRAIN_RGD_ID3 and STRAIN_RGD_SYMBOL3 for qtls that have 3+ crossed strains ### Jun 17 2019 data sorted by RGD ID; files exported into species specific directories ### Oct 26 2022 added generation of positions on rn7 assembly # #COLUMN INFORMATION: # (First 25 columns are in common between rat, mouse and human) # #1 QTL_RGD_ID the RGD_ID of the QTL #2 SPECIES species name #3 QTL_SYMBOL official qtl symbol #4 QTL_NAME current qtl name #5 CHROMOSOME_FROM_REF the chromosome from the original paper #6 LOD maximum LOD score if given in paper #7 P_VALUE p-value for QTL if given in paper #8 VARIANCE variance if given in paper #9 FLANK_1_RGD_ID RGD_ID for flank marker 1, if in paper #10 FLANK_1_SYMBOL symbol for flank marker 1, if in paper #11 FLANK_2_RGD_ID RGD_ID for flank marker 2, if in paper #12 FLANK_2_SYMBOL symbol for flank marker 2, if in paper #13 PEAK_RGD_ID RGD_ID for peak marker, if in paper #14 PEAK_MARKER_SYMBOL symbol for peak marker, if in paper #15 TRAIT_NAME trait created for QTL #16 MEASUREMENT_TYPE measurement type for QTL #17 (UNUSED) #18 PHENOTYPES phenotype ontology annotation #19 ASSOCIATED_DISEASES diseases ontology annotation #20 CURATED_REF_RGD_ID RGD_ID of paper(s) on QTL #21 CURATED_REF_PUBMED_ID PUBMED_ID of paper(s) on QTL #22 CANDIDATE_GENE_RGD_IDS RGD_IDS for genes mentioned by paper author #23 CANDIDATE_GENE_SYMBOLS symbols for genes mentioned by paper author #24 INHERITANCE_TYPE dominant, recessive etc. #25 RELATED_QTLS symbols of related QTLS #26 (UNUSED) #27 5.0_MAP_POS_CHR chromosome for assembly Rnor_5.0 #28 5.0_MAP_POS_START start position for assembly Rnor_5.0 #29 5.0_MAP_POS_STOP stop position for assembly Rnor_5.0 #30 5.0_MAP_POS_METHOD qtl positioning method for assembly Rnor_5.0 #31 3.4_MAP_POS_CHR chromosome for assembly RGSC 3.4 #32 3.4_MAP_POS_START start position for assembly RGSC 3.4 #33 3.4_MAP_POS_STOP stop position for assembly RGSC 3.4 #34 3.4_MAP_POS_METHOD qtl positioning method for assembly RGSC 3.4 #35 CROSS_TYPE strain cross type #36 CROSS_PAIR pairing of strains for cross #37 STRAIN_RGD_ID1 RGD_ID of first strain crossed #38 STRAIN_RGD_ID2 RGD_ID of second strain crossed #39 STRAIN_RGD_SYMBOL1 symbol of first strain crossed #40 STRAIN_RGD_SYMBOL2 symbol of second strain crossed #41 6.0_MAP_POS_CHR chromosome for assembly Rnor_6.0 #42 6.0_MAP_POS_START start position for assembly Rnor_6.0 #43 6.0_MAP_POS_STOP stop position for assembly Rnor_6.0 #44 6.0_MAP_POS_METHOD qtl positioning method for assembly Rnor_6.0 #45 STRAIN_RGD_ID3 RGD_ID of third strain crossed #46 STRAIN_RGD_SYMBOL3 symbol of third strain crossed #47 7.2_MAP_POS_CHR chromosome for assembly mRatBN7.2 #48 7.2_MAP_POS_START start position for assembly mRatBN7.2 #49 7.2_MAP_POS_STOP stop position for assembly mRatBN7.2 #50 7.2_MAP_POS_METHOD qtl positioning method for assembly mRatBN7.2 # QTL_RGD_ID SPECIES QTL_SYMBOL QTL_NAME CHROMOSOME_FROM_REF LOD P_VALUE VARIANCE FLANK_1_RGD_ID FLANK_1_SYMBOL FLANK_2_RGD_ID FLANK_2_SYMBOL PEAK_RGD_ID PEAK_MARKER_SYMBOL TRAIT_NAME MEASUREMENT_TYPE (UNUSED) PHENOTYPES ASSOCIATED_DISEASES CURATED_REF_RGD_ID CURATED_REF_PUBMED_ID CANDIDATE_GENE_RGD_IDS CANDIDATE_GENE_SYMBOLS INHERITANCE_TYPE RELATED_QTLS (UNUSED) 5.0_MAP_POS_CHR 5.0_MAP_POS_START 5.0_MAP_POS_STOP 5.0_MAP_POS_METHOD 3.4_MAP_POS_CHR 3.4_MAP_POS_START 3.4_MAP_POS_STOP 3.4_MAP_POS_METHOD CROSS_TYPE CROSS_PAIR STRAIN_RGD_ID1 STRAIN_RGD_ID2 STRAIN_RGD_SYMBOL1 STRAIN_RGD_SYMBOL2 6.0_MAP_POS_CHR 6.0_MAP_POS_START 6.0_MAP_POS_STOP 6.0_MAP_POS_METHOD STRAIN_RGD_ID3 STRAIN_RGD_SYMBOL3 7.2_MAP_POS_CHR 7.2_MAP_POS_START 7.2_MAP_POS_STOP 7.2_MAP_POS_METHOD 61324 rat Eae5 Experimental allergic encephalomyelitis QTL 5 12 14.0 11051 D12Mit2 34925 D12Rat9 nervous system integrity trait (VT:0010566) percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031;2306769 10640775;19299744 Ean6 (maps to same region);Pia4 (maps to same region) 12 24662983 28287040 1 - by flanking markers 12 20932559 24470522 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 12 22650702 52716770 4 - by one flank marker only 12 19610870 46669029 4 - by one flank marker only 61325 rat Aia5 Adjuvant induced arthritis QTL 5 10 0.01 61274 D10Arb20 61275 D10Arb22 10466 D10Mit1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 625379;61519;61073;629560;69693 11953987;10323205;12571866;10087293 Cari1 (interacts with);Cia3 (maps to same region);Cia5 (interacts with);Eau3 (maps to same region);Pia10 (interacts with);Pia5 (maps to same region) 10 24340447 107484761 1 - by flanking markers 10 24006429 110718848 2 - by one flank and peak markers Congenic DA.F344 Congenic 61114 631282 DA/Bkl DA.F344-(D10Arb20-D10Arb22)/Arb 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers 61326 rat Eae6 Experimental allergic encephalomyelitis QTL 6 1 5.3 34399 D1Mgh9 10951 D1Mit13 34326 D1Mgh21 body mass (VT:0001259) change in body weight (CMO:0002045) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 1 195235368 205649793 1 - by flanking markers 1 176854992 186472032 1 - by flanking markers F2 E3xDA;E3 x DA 60997 61013 DA E3 1 188289244 198656062 1 - by flanking markers 1 172949660 181830018 1 - by flanking markers 61327 rat Eae7 Experimental allergic encephalomyelitis QTL 7 1 5.6 33903 D1Mit7 10674 D1Mgh12 10445 D1Wox25 body mass (VT:0001259) change in body weight (CMO:0002045) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031;61039;2302026 10640775;7537756;14674011 Pia35 (maps to same region) 1 262617194 270717037 1 - by flanking markers 1 240980142 247322277 1 - by flanking markers F2 E3xDA;E3 x DA 60997 61013 DA E3 1 236265430 281265430 5 - by peak with adj size 1 216255568 260522016 5 - by peak with adj size 61328 rat Eae8 Experimental allergic encephalomyelitis QTL 8 19 4.0 11471 D19Mit9 34033 D19Mit5 nervous system integrity trait (VT:0010566) percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031;2302026 10640775;14674011 Pia34 (maps to same region) 19 35435631 48006398 1 - by flanking markers 19 26534809 34998604 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 19 24457627 37140233 1 - by flanking markers 19 24816041 33061905 1 - by flanking markers 61329 rat Eae9 Experimental allergic encephalomyelitis QTL 9 6 3.7 34098 D6Mgh3 35821 D6Rat10 body mass (VT:0001259) change in body weight (CMO:0002045) paresis multiple sclerosis 61031 10640775 6 136507025 156897508 4 - by one flank marker only 6 127683728 147636619 4 - by one flank marker only F2 E3 x DA 60997 61013 DA E3 6 127286494 147991367 4 - by one flank marker only 6 122549046 140994061 4 - by one flank marker only 61330 rat Eau1 Experimental allergic uveoretinitis QTL 1 4 3.0E-4 11173 D4Arb8 34001 D4Mit17 11013 D4Arb7 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation Experimental Autoimmune Uveitis 61073;2293749;2296064;61035;61064 10323205;18281616;18453595;9780220;10331011 3197;3834 Npy;Tcrb Aia2 (interacts with);Aia3 (maps to same region);Cia3 (maps to same region);Iddm2 (maps to same region);Scwia1 (interacts with,maps to same region) 4 135563448 196943890 1 - by flanking markers 4 69183301 134858710 1 - by flanking markers F2 LEWxF344 60999 70509 LEW F344/NRrrc 4 70773471 132455556 1 - by flanking markers 4 70362013 132642728 1 - by flanking markers 61331 rat Eau2 Experimental allergic uveoretinitis QTL 2 12 5.0E-4 41960 D12Arb2 61278 D12Arb5 41960 D12Arb2 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation Experimental Autoimmune Uveitis 61073;2293749;2296064 10323205;18281616;18453595 Cia12 (interacts with);Pia4 (interacts with) 12 12361595 33647566 1 - by flanking markers 12 1 29130348 4 - by one flank marker only F2 LEWxF344 60999 70509 LEW F344/NRrrc 12 10256890 31723732 1 - by flanking markers 12 8525423 28064601 1 - by flanking markers 61332 rat Eau3 Experimental allergic uveoretinitis QTL 3 10 0.004 61279 D10Arb3 33941 D10Mit11 34053 D10Mit3 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation Experimental Autoimmune Uveitis 61073;2293749;2296064;61519 10323205;18281616;18453595 2836;3395;3645;3772;3773;3774;3877;3967;61276;69069;1594396 Hsd17b1;Prkca;Ccl2;Stat3;Stat5a;Stat5b;Tnfaip1;Vtn;Crhr1;Ccl5;Trim25 Aia5 (maps to same region);Cari1 (interacts with);Cia5 (maps to same region);Oia3 (interacts with);Pia10 (interacts with,maps to same region) 10 35428279 46754773 2 - by one flank and peak markers 10 35713452 101848683 1 - by flanking markers F2 LEWxF344 60999 70509 LEW F344/NRrrc 10 35669465 46851407 2 - by one flank and peak markers 10 34490559 45579777 2 - by one flank and peak markers 61333 rat Gluco16 Glucose level QTL 16 4 4.3 1.0E-5 42144 D4Arb13 adipocyte glucose uptake trait (VT:0004185) absolute change in adipocyte glucose uptake (CMO:0000873) abnormal adipocyte glucose uptake Insulin Resistance 61078 9171835 4 1 26838530 5 - by peak with adj size 4 1 25671721 5 - by peak with adj size F2 61096 61097 SHR/NCruk WKY/NCruk 4 1 26803291 5 - by peak with adj size 4 1 30372989 5 - by peak with adj size 61334 rat Gluco17 Glucose level QTL 17 12 6.3 34025 D12Mit8 34439 D12Mgh1 adipocyte glucose uptake trait (VT:0004185) adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874) abnormal adipocyte glucose uptake Insulin Resistance 61078 9171835 dominant 12 1 15941791 4 - by one flank marker only 12 1 12240883 4 - by one flank marker only F2 61096 61097 SHR/NCruk WKY/NCruk 61335 rat Bp20 Blood pressure QTL 20 3 3.0 34316 D3Mgh2 33810 D3Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045 9132270 3 154751731 169801009 1 - by flanking markers 3 143214737 158037866 1 - by flanking markers F2 SHR x BN 60985 61000 BN SHR 3 148348739 163640325 1 - by flanking markers 3 141339236 155617360 1 - by flanking markers 61336 rat Bp21 Blood pressure QTL 21 4 4.6 3197 Npy 33757 D4Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;631223;2306880 9132270;11474180;19126752 3239 Oxtr Bp338 (maps to same region) 4 55539285 144233753 1 - by flanking markers 4 55370202 78038013 1 - by flanking markers F2 SHR x BN 60985 61000 BN SHR 4 55791834 79557856 1 - by flanking markers 4 57114705 78881294 1 - by flanking markers 61337 rat Bp22 Blood pressure QTL 22 8 5.1 33559 D8Mit5 33887 D8Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;61054 9132270;9045857 Bp35 (interacts with);Bp39 (interacts with) 8 33603024 45061597 1 - by flanking markers 8 32203394 45291808 1 - by flanking markers intercross;F2 SHRxBN;SHR x BN 60985 61000 BN SHR 8 33558660 46588570 1 - by flanking markers 8 30848154 42692818 1 - by flanking markers 61338 rat Bp23 Blood pressure QTL 23 16 4.3 33848 D16Mit2 33652 D16Mit5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;2306880 9132270;19126752 Bp339 (maps to same region) 16 4954192 49954192 4 - by one flank marker only 16 4304396 49304396 4 - by one flank marker only intercross;F2 SHRxBN;SHR x BN 60985 61000 BN SHR 16 5013802 50013802 4 - by one flank marker only 16 4227609 49227609 4 - by one flank marker only 61339 rat Bp24 Blood pressure QTL 24 13 0.05 33923 D13Mit1 3554 Ren arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 61046;61057;61043;61037 8567976;7981757;8952608;1363813 Bp11 (maps to same region,interacts with);Bp25 (interacts with);Bp31 (interacts with);Bp5 (maps to same region) 13 14281836 55566812 1 - by flanking markers 13 25430110 46275213 1 - by flanking markers F2 10040 10041 SR/Jr SS/Jr 13 9016742 50513953 1 - by flanking markers 13 5994668 44807491 1 - by flanking markers 61340 rat Bp25 Blood pressure QTL 25 13 4.2 0.004 34371 D13Mgh3 61281 D13M1Mit108 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61047;61057;61043;61046;61037 9271663;7981757;8952608;8567976;1363813 Bp11 (interacts with);Bp24 (interacts with);Bp31 (interacts with);Bp5 (interacts with) 13 44494434 89494434 4 - by one flank marker only 13 35472372 80472372 4 - by one flank marker only F2 SS/Jr x SR/Jr 10040 10041 SR/Jr SS/Jr 13 39372927 84372927 4 - by one flank marker only 13 34535218 79535218 4 - by one flank marker only 61341 rat Bp26 Blood pressure QTL 26 1 60787 D1Wox6 43424 D1Wox10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61048;61060;61040;61050;61051 9336384;8528250;9685318;8094726;9774356 Bp197 (interacts with);Bp28 (interacts with,maps to same region);Bp29 (interacts with);Bp30 (interacts with,maps to same region) 1 138777913 244066407 1 - by flanking markers 1 131956599 220639653 1 - by flanking markers F2 61100 628908 SHR/Ola SHR.BN-(D1Mit3-Igf2)/Ipcv 1 137787261 236763528 1 - by flanking markers 737972 BN/Crl 1 169537671 214537671 4 - by one flank marker only 61342 rat Bp27 Blood pressure QTL 27 1 3.4 6.0E-4 61282 D1M7Mit69 61283 D1Mco2 61284 D1Mco1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61049;61040;68885;2291850 8609235;9685318;11160999;18324438 Bp93 (interacts with);Bp94 (interacts with);Bp95 (interacts with) 1 58687835 77717707 2 - by one flank and peak markers F2 10041 60999 SS/Jr LEW 1 57761301 104391981 1 - by flanking markers 1 56732668 98773277 1 - by flanking markers 61343 rat Bp28 Blood pressure QTL 28 1 62086 Acsm3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61050;61060;628394;61048;61049 8094726;8528250;12215469;9336384;8609235 Bp197 (interacts with);Bp26 (interacts with,maps to same region);Bp29 (maps to same region,interacts with);Bp30 (interacts with) 1 173962319 218962319 5 - by peak with adj size 1 155568068 200568068 5 - by peak with adj size F2 SHRSP x WKY 61010 61103 SHRSP WKY 1 167027868 212027868 5 - by peak with adj size 1 151646613 196646613 5 - by peak with adj size 61344 rat Bp29 Blood pressure QTL 29 1 7.5 34011 D1Mit2 60784 D1Wox29 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61051;628394;61060;61048;61049;61050 9774356;12215469;8528250;9336384;8609235;8094726 Bp160 (interacts with);Bp161 (interacts with);Bp197 (interacts with);Bp26 (interacts with);Bp28 (interacts with,maps to same region);Bp30 (interacts with) 1 86822376 131822376 4 - by one flank marker only 1 124614852 134980526 1 - by flanking markers F2 SHR x WKY 61097 629482 WKY/NCruk WKY.SHR-(D1Wox19-D1Mit2)/Njs 1 85779320 130779320 4 - by one flank marker only 1 78350581 123350581 4 - by one flank marker only 61345 rat Rf1 Renal disease susceptibility QTL 1 1 8.9 33571 D1Mit6 10674 D1Mgh12 urine protein amount (VT:0005160) urine protein excretion rate (CMO:0000759) glomerulosclerosis;increased urine protein level end stage renal disease 61060;61090;1299961;1359045;625641;1582571;1643000;70856 8528250;7704027;15060005;15976509;11875190;16837819;17413446;11053483 2721;3780;69193;69327;70931;620485;620716;621077;621325;621578;621721 Got1;Slk;Hps1;Arl3;Cpn1;Pi4k2a;Sfxn3;Oga;As3mt;Nolc1;Avpi1 1 225717037 270717037 4 - by one flank marker only 1 202322277 247322277 4 - by one flank marker only (FHH x ACI) x FHH Backcross ACIxFHH;FHH x ACI 10000 10015 ACI/N FHH/Eur 61346 rat Rf2 Renal disease susceptibility QTL 2 1 3.7 34011 D1Mit2 33959 D1Mit3 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulosclerosis;increased urine protein level end stage renal disease 61060;61090;1357409;70856 8528250;7704027;15758045;11053483 1 117692800 162692800 4 - by one flank marker only 1 134980526 146971983 1 - by flanking markers (FHH x ACI) x FHH Backcross ACIxFHH;FHH x ACI 10000 60993 ACI/N FHH 1 111446783 156446783 4 - by one flank marker only 1 99267916 144267916 4 - by one flank marker only 61347 rat Bp197 Blood pressure QTL 197 1 4.2 3118 Mt1-ps1 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 61060;1643000;70856 8528250;17413446;11053483 Bp26 (interacts with);Bp28 (interacts with);Bp29 (interacts with);Bp30 (interacts with) 1 182441645 227441645 5 - by peak with adj size 1 163190108 208190108 5 - by peak with adj size (FHH x ACI) x FHH Backcross FHH x ACI 10000 60993 ACI/N FHH 1 175462885 220462885 5 - by peak with adj size 1 158633083 203633083 5 - by peak with adj size 61348 rat Bp30 Blood pressure QTL 30 1 2.4 2870 Igf2 42061 D1Arb15 62086 Acsm3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61049;61040;619643;61060;68885;2291850;628394;61048;61050 8609235;9685318;10523340;8528250;11160999;18324438;12215469;9336384;8094726 62086 Acsm3 Bp197 (interacts with);Bp26 (maps to same region,interacts with);Bp28 (interacts with);Bp29 (interacts with);Bp88 (maps to same region);Bp93 (interacts with);Bp94 (interacts with);Bp95 (interacts with) 1 160642307 222722921 1 - by flanking markers 1 146714502 202906624 1 - by flanking markers F2 SS/Jr x LEW/NCrLBR 10041 61104 SS/Jr LEW/NCrl 1 154337847 215828102 1 - by flanking markers 1 144017057 197814409 1 - by flanking markers 61349 rat Bp31 Blood pressure QTL 31 13 5.75 33733 D13Mit2 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 61043;61057;61046;61037 8952608;7981757;8567976;1363813 Bp11 (interacts with,maps to same region);Bp24 (interacts with);Bp25 (interacts with);Bp5 (maps to same region,interacts with) 13 47487222 92487222 5 - by peak with adj size 13 39572400 84572400 5 - by peak with adj size F2 SHR x WKY 61000 61103 SHR WKY 13 42508345 87508345 5 - by peak with adj size 13 37374509 82374509 5 - by peak with adj size 61350 rat Bp32 Blood pressure QTL 32 19 0.012 33618 D19Mit7 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61044;61055 7560090;9199194 Bp46 (interacts with) 19 35632220 72914587 5 - by peak with adj size 19 22590859 59218465 5 - by peak with adj size F2 SHR x BN 61098 61099 BXH/Ipcv HXB/Ipcv 19 24818257 62275575 5 - by peak with adj size 19 20483575 57337602 5 - by peak with adj size 61351 rat Bp33 Blood pressure QTL 33 4 0.0018 2901 Il6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61044 7560090 4 1 25597824 5 - by peak with adj size 4 1 22959087 5 - by peak with adj size F2 SHR x BN 61098 61099 BXH/Ipcv HXB/Ipcv 4 1 25545519 5 - by peak with adj size 4 1 27716890 5 - by peak with adj size 61352 rat Bp34 Blood pressure QTL 34 9 5.0 61287 D9Uia6 61288 D9Uia9 2912 Inha arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61053;619653;2302803 9722941;11161799;18854752 Bp333 (maps to same region);Bp334 (interacts with) 9 46637534 83451810 1 - by flanking markers 9 39390033 77170797 1 - by flanking markers F2 SS/Jr x SR/Jr 10040 10041 SR/Jr SS/Jr 9 46952427 83686153 1 - by flanking markers 9 42495343 79271511 1 - by flanking markers 61353 rat Bp35 Blood pressure QTL 35 8 0.001 33559 D8Mit5 34415 D8Mgh6 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61054;61040;61045 9045857;9685318;9132270 Bp22 (interacts with);Bp39 (interacts with) 8 33603024 65467051 1 - by flanking markers 8 32203394 64762616 1 - by flanking markers F2 61106 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv 8 33558660 65717592 1 - by flanking markers 8 30848154 61290444 1 - by flanking markers 61354 rat Pia10 Pristane induced arthritis QTL 10 10 0.01 61274 D10Arb20 61275 D10Arb22 10466 D10Mit1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61519;629569;61073 12209529;10323205 2836;3395;3772;3773;3774;3877;61276;1594396 Hsd17b1;Prkca;Stat3;Stat5a;Stat5b;Tnfaip1;Crhr1;Trim25 Aia5 (interacts with);Cia5 (maps to same region);Eau3 (interacts with,maps to same region);Oia3 (interacts with) 10 24340447 107484761 1 - by flanking markers 10 24006429 110718848 2 - by one flank and peak markers Congenic DA/F344 Congenic 631282 DA.F344-(D10Arb20-D10Arb22)/Arb 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers 61355 rat Bp36 Blood pressure QTL 36 2 2.9 2071 Agtr1b 33943 D2Mit1 61289 D2Mco19 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;61037 9685318;1363813 Bp10 (interacts with) 2 3125162 124879262 1 - by flanking markers 2 3429900 105503269 1 - by flanking markers F2 SS/Jr x LEW 10041 60999 SS/Jr LEW 2 3127638 105149020 1 - by flanking markers 2 5873687 102844969 1 - by flanking markers 61356 rat Bp37 Blood pressure QTL 37 3 3.0 34146 D3Mgh6 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;631223 9685318;11474180 3238 Oxt 3 38749889 83749889 5 - by peak with adj size 3 28022667 73022667 5 - by peak with adj size F2 SS/Jr x LEW 10041 60999 SS/Jr LEW 3 32130997 77130997 5 - by peak with adj size 3 30684642 75684642 5 - by peak with adj size 61357 rat Bp38 Blood pressure QTL 38 7 1.6 0.052 4.8 34395 D7Mgh1 62504 D7Uia3 33648 D7Mit5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;4891049;7421500 9685318;21192272;23814039 3809;628723;735050 Tac3;Nxph4;Rdh16 Bp279 (interacts with);Bp310 (interacts with) 7 48134589 128652785 2 - by one flank and peak markers 7 44698822 125481104 2 - by one flank and peak markers F2 SS/Jr x LEW 10041 61104 SS/Jr LEW/NCrl 7 48118835 128611831 2 - by one flank and peak markers 7 41333674 119109060 2 - by one flank and peak markers 61358 rat Bp39 Blood pressure QTL 39 8 2.0 44436 D8Wox2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;61045;61054 9685318;9132270;9045857 Bp22 (interacts with);Bp35 (interacts with) 8 39705473 84705473 5 - by peak with adj size 8 38902937 83902937 5 - by peak with adj size F2 SS/Jr x LEW 10040 10041 SR/Jr SS/Jr 8 39927901 84927901 5 - by peak with adj size 8 35551938 80551938 5 - by peak with adj size 61359 rat Eaex Experimental allergic encephalomyelitis QTL x 5 3.0 33678 D5Mit10 43924 D5Wox21 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 5 61438645 106438645 4 - by one flank marker only 5 57974567 102974567 4 - by one flank marker only F2 E3 x DA 60997 61013 DA E3 5 56902367 101902367 4 - by one flank marker only 5 55715622 100715622 4 - by one flank marker only 61360 rat Eaey Experimental allergic encephalomyelitis QTL y 18 3.0 34156 D18Mgh1 10648 D18Wox13 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis duration (CMO:0001424) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 18 47731030 61757188 1 - by flanking markers 18 49034213 87265094 4 - by one flank marker only F2 E3 x DA 60997 61013 DA E3 18 48519299 62570427 1 - by flanking markers 18 46988939 60377753 1 - by flanking markers 61362 rat Oia2 Oil induced arthritis QTL 2 4 0.001 34174 D4Mgh7 33778 D4Mit21 34473 D4Mgh10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61087;61068;629560;2300074;1582387;2324629;61067 9600974;9692888;12571866;18606636;16804090;20200546;11001927 Cia13 (maps to same region,interacts with);Cia3 (maps to same region);Ciaa4 (maps to same region);Oia3 (interacts with);Pia7 (maps to same region);RA20_H (maps to syntenic region) 4 200825021 244267149 2 - by one flank and peak markers 4 136668162 181668162 5 - by peak with adj size F2 60997 737657 DA LEW.1AV1 4 136351734 174694858 2 - by one flank and peak markers 4 138503169 173369699 2 - by one flank and peak markers 61363 rat Oia3 Oil induced arthritis QTL 3 10 0.001 11308 D10Wox20 34128 D10Mgh1 34128 D10Mgh1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61087;61068;62404;2300074;1582387;2307198;61073;2306769;61519 9600974;9692888;11230175;18606636;16804090;18540828;10323205;19299744 Ean5 (maps to same region);Eau3 (interacts with);Oia2 (interacts with);Oia4 (maps to same region);Oia5 (maps to same region);Oia6 (maps to same region);Pia10 (interacts with) 10 90085487 112200500 4 - by one flank marker only 10 91455572 110718848 4 - by one flank marker only F2 631595 LEW.1AV1.DA-(D10Rat92-D10Rat135)/Ubc 10 90296897 112626471 4 - by one flank marker only 10 87307617 107211142 4 - by one flank marker only 61364 rat Iddm2 Insulin dependent diabetes mellitus QTL 2 4 11014 D4Mit7 10782 D4Mit8 11014 D4Mit7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 61075;61032;61481;61073 1303251;9530633;10441739;10323205 Eau1 (maps to same region);Iddm1 (interacts with) F2 BB/DP x BB/DR, BB/DP x F344, BB/DP x LEW 10002 10003 BBDP/Rhw BBDR/Rhw 4 79562451 98542106 1 - by flanking markers 4 78885890 102684881 1 - by flanking markers 61365 rat Iddm1 Insulin dependent diabetes mellitus QTL 1 20 3.54 0.001 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased T cell number;increased circulating glucose level type 1 diabetes mellitus 61076;61075 7026724;1303251 Iddm2 (interacts with) F2 BB/DP x BB/DR, BB/DP x F344, BB/DP x LEW 10002 60999 BBDP/Rhw LEW 61366 rat Iddm3 Insulin dependent diabetes mellitus QTL 3 2 4.7 33727 D2Mit14 33763 D2Mit15 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level;obese type 1 diabetes mellitus 61481;61075;2303106 10441739;1303251;19168599 Iddm26 (maps to same region) 2 224018348 269018348 4 - by one flank marker only 2 197256223 242256223 4 - by one flank marker only F2 (F344 +/+,lv/lv x BB/DR lyp/lyp,u/u) x BB/DR lyp/lyp,u/u 10003 70509 BBDR/Rhw F344/NRrrc 2 204585642 249585642 4 - by one flank marker only 2 189599258 234599258 4 - by one flank marker only 61367 rat Iddm4 Insulin dependent diabetes mellitus QTL 4 18 2.33 0.0074 2715 Gnal blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 61077;625443;61075;61035 9571179;8586150;1303251;9780220 Aia2 (interacts with) 18 39561579 84561579 5 - by peak with adj size 18 41165704 86165704 5 - by peak with adj size F2;backcross BB/OKxDA 60997 61107 DA BB/OK 18 40375769 85375769 5 - by peak with adj size 18 38192455 83192455 5 - by peak with adj size 61368 rat Mcs1 Mammary carcinoma susceptibility QTL 1 2 4.4 33822 D2Mit29 61291 D2Uwm15 35901 D2Rat3 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61080;61081;2291885 8168109;9584103;18057545 2 5396621 40863012 1 - by flanking markers 2 5601528 22318848 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 2 5417336 21657459 1 - by flanking markers 2 7887772 23319447 1 - by flanking markers 61369 rat Mcs2 Mammary carcinoma susceptibility QTL 2 7 3.38 34166 D7Mgh15 61292 D7Uwm9 34051 D7Mit28 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61081;2291885;5133689 9584103;18057545;21625632 Mcs6 (sub_region) 7 24887102 40471913 1 - by flanking markers 7 21161002 38377911 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 7 24738680 40433335 1 - by flanking markers 7 19032807 35526300 1 - by flanking markers 61370 rat Mcs3 Mammary carcinoma susceptibility QTL 3 1 2.15 33686 D1Mit11 34011 D1Mit2 60787 D1Wox6 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61081;2291885 9584103;18057545 1 109100679 168455345 2 - by one flank and peak markers 1 102532145 134980682 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 1 108057233 167517487 2 - by one flank and peak markers 1 102268556 147268556 4 - by one flank marker only 61371 rat Edpm1 Estrogen-dependent pituitary mass QTL 1 2 4.0 0.05 9.6 34425 D2Mgh1 33553 D2Mit7 33824 D2Mit4 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 additive 2 53216438 110970864 2 - by one flank and peak markers 2 34914943 79914943 4 - by one flank marker only intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 2 34088175 91101903 2 - by one flank and peak markers 2 35134841 88029593 2 - by one flank and peak markers 61372 rat Bp40 Blood pressure QTL 40 16 2.2 11448 D16Wox11 33848 D16Mit2 11448 D16Wox11 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040 9685318 16 5038806 19256512 1 - by flanking markers 16 4304517 18121285 1 - by flanking markers F2 SS/Jr x LEW 10041 60999 SS/Jr LEW 16 5098704 19398181 1 - by flanking markers 16 4227730 17696785 1 - by flanking markers 61373 rat Mcs4 Mammary carcinoma susceptibility QTL 4 8 1.1 10437 D8Mgh13 34415 D8Mgh6 10437 D8Mgh13 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 61081;737837;2291885 9584103;18057545 2458;2459 Cyp1a1;Cyp1a2 8 20467051 65467051 4 - by one flank marker only 8 61443447 64762616 1 - by flanking markers (WF x COP) F1 x WF backcross WF x COP 60998 61007 COP WF 8 20717592 65717592 4 - by one flank marker only 8 16290444 61290444 4 - by one flank marker only 61374 rat Edpm2 Estrogen-dependent pituitary mass QTL 2 2 4.42 0.86 9.2 33620 D2Mit6 34461 D2Mgh12 34114 D2Mgh15 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 2 98037122 235592880 1 - by flanking markers 2 77630629 210636169 1 - by flanking markers intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 2 78321410 217498710 1 - by flanking markers 2 76539322 202447032 1 - by flanking markers 61375 rat Bp41 Blood pressure QTL 41 18 2.4 61294 D18Mco3 11461 D18Mit1 33766 D18Mit4 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040;61036 9685318;1655275 Bp2 (maps to same region) 18 15314271 29235489 1 - by flanking markers 18 29344142 80277631 1 - by flanking markers F2 SS/Jr x SR/Jr 10040 10041 SR/Jr SS/Jr 18 15539671 29530300 1 - by flanking markers 18 11944299 41122201 2 - by one flank and peak markers 61376 rat Bp42 Blood pressure QTL 42 1 23.4 2870 Igf2 10674 D1Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055;1626643 9199194;16700878 Bp306 (maps to same region) 1 222722921 270717037 1 - by flanking markers 1 202906624 247322277 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 1 215828102 260828102 4 - by one flank marker only 1 197814409 242814409 4 - by one flank marker only 61377 rat Edpm3 Estrogen-dependent pituitary mass QTL 3 3 7.05 0.038 16.6 10293 D3Mit7 34146 D3Mgh6 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074;1581610 9337394;16416090 additive 3 61249938 100057451 1 - by flanking markers 3 50522717 88648420 1 - by flanking markers intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 3 54631046 93415673 1 - by flanking markers 3 53184692 89878207 1 - by flanking markers 61378 rat Bp43 Blood pressure QTL 43 1 22.6 3750 Spn 3643 Sct arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 1 205563659 221191992 1 - by flanking markers 1 186388120 201472944 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 1 198572999 214277437 1 - by flanking markers 1 181746937 196383668 1 - by flanking markers 61379 rat Bp44 Blood pressure QTL 44 1 19.2 62086 Acsm3 33959 D1Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 1 162692800 196449042 1 - by flanking markers 1 146971983 178054386 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 1 156446783 189514504 1 - by flanking markers 1 144267916 174133260 1 - by flanking markers 61380 rat Edpm5 Estrogen-dependent pituitary mass QTL 5 5 4.5 0.92 9.4 34216 D5Mgh6 34041 D5Mit5 33985 D5Mit11 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent;Pituitary Neoplasms 61074;1300042 9337394;15166088 additive 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 61381 rat Bp45 Blood pressure QTL 45 10 23.2 3385 Ppy 61296 Aoc1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 61382 rat Bp46 Blood pressure QTL 46 18 18.8 3916 Ttr 2741 Nr3c1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055;61036 9199194;1655275 Bp2 (interacts with,maps to same region);Bp32 (interacts with) 18 15307563 32348480 1 - by flanking markers 18 12406571 32459145 1 - by flanking markers intercross;F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 18 15532963 32704022 1 - by flanking markers 18 11941791 31393320 1 - by flanking markers 61383 rat Bp47 Blood pressure QTL 47 18 17.3 2741 Nr3c1 10647 D18Wox12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 18 31408742 61757190 1 - by flanking markers 18 32371496 62660224 1 - by flanking markers F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 18 31728373 62570429 1 - by flanking markers 18 31271681 60377755 1 - by flanking markers 61384 rat Bp48 Blood pressure QTL 48 18 19.4 2715 Gnal 33814 D18Mit9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61055 9199194 18 61991738 79748387 1 - by flanking markers 18 63595606 80370517 1 - by flanking markers intercross;F2 BB/OK x SHR/Mol 61107 61110 BB/OK SHR/Mol 18 62805406 80696375 1 - by flanking markers 18 60622311 77209844 1 - by flanking markers 61385 rat Edpm9 Estrogen-dependent pituitary mass QTL 9 9 3.43 0.05 6.5 34088 D9Mgh2 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Neoplasms, Hormone-Dependent 61074 9337394 additive 9 69971937 114971937 5 - by peak with adj size 9 61932939 106932939 5 - by peak with adj size intercross F344/NHsd x BN/SsNHsd 10008 61109 BN/SsNHsd F344/NHsd 9 70241351 115241351 5 - by peak with adj size 9 63869687 108869687 5 - by peak with adj size 61386 rat Bp49 Blood pressure QTL 49 5 16.6 33836 D5Mit9 43930 D5Wox4 3193 Nppa cerebrum integrity trait (VT:0010549) brain infarction volume (CMO:0001013) increased cerebral infarct size;increased systemic arterial blood pressure brain infarction;hypertension 61056;1553895 9241273;15454664 3193 Nppa 5 66128197 106340276 1 - by flanking markers 5 62555131 103059258 1 - by flanking markers F2 SHRSP x WKY 61010 61103 SHRSP WKY 5 61612600 102331727 1 - by flanking markers 5 60293434 98603051 1 - by flanking markers 61387 rat Bp1 Blood pressure QTL 1 10 5.1 33941 D10Mit11 3138 Myh3 2686 Gh1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61036;2312779 1655275;15800376 2493 Ace Bp133 (maps to same region);Bp134 (maps to same region) 10 53372408 112200500 2 - by one flank and peak markers 10 53800677 101848470 1 - by flanking markers intercross;F2 SHRSPxWKY 61010 61103 SHRSP WKY 10 53621375 112626471 2 - by one flank and peak markers 10 51770177 107211142 2 - by one flank and peak markers 61388 rat Bp2 Blood pressure QTL 2 18 3.23 33971 D18Mit7 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 61036;61055 1655275;9199194 Bp41 (maps to same region);Bp46 (maps to same region,interacts with) 18 1 34885573 5 - by peak with adj size 18 1 35739743 5 - by peak with adj size F2 SHRSPxWKY 61010 61103 SHRSP WKY 18 1 35097280 5 - by peak with adj size 18 1 35374722 5 - by peak with adj size 61389 rat Bp3 Blood pressure QTL 3 X 1.0E-4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61052 1656270 F2 SHRSP x WKY 61010 61103 SHRSP WKY 61390 rat Bp4 Blood pressure QTL 4 10 19.0 1.0E-4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61052 1656270 F2 SHRSP x WKY 61010 61103 SHRSP WKY 61391 rat Bp5 Blood pressure QTL 5 13 5.6 3554 Ren arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure;increased systemic arterial diastolic blood pressure hypertension 61057;61043;61046;61037 7981757;8952608;8567976;1363813 Bp11 (interacts with,maps to same region);Bp24 (maps to same region);Bp25 (interacts with);Bp31 (maps to same region,interacts with) 13 33061197 78061197 5 - by peak with adj size 13 23769074 68769074 5 - by peak with adj size F2 LH x LN 10021 10022 LH/Mav LN/Mav 13 28008338 73008338 5 - by peak with adj size 13 22301875 67301875 5 - by peak with adj size 61392 rat Bp6 Blood pressure QTL 6 2 7.0 2391 Cpb1 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) increased pulse pressure;increased systemic arterial blood pressure hypertension 61057;68910 7981757;10642295 Bp13 (maps to same region) 2 102319298 147319298 5 - by peak with adj size 2 82928622 127928622 5 - by peak with adj size F2 LH x LN 10021 10022 LH/Mav LN/Mav 2 82574487 127574487 5 - by peak with adj size 2 80270434 125270434 5 - by peak with adj size 61393 rat Bp7 Blood pressure QTL 7 5 4.5 1.0E-4 33836 D5Mit9 61299 D5Mco10 2533 Edn2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61059;61040;619653 8201007;9685318;11161799 2533 Edn2 5 66128197 171686754 1 - by flanking markers 5 62555131 168174140 1 - by flanking markers F2 SS/Jr x LEW 10041 61104 SS/Jr LEW/NCrl 5 61612600 168109659 1 - by flanking markers 5 60293434 161481680 1 - by flanking markers 61394 rat Bp8 Blood pressure QTL 8 17 2.2 8.5 61300 D17Mco3 61301 D17Mco10 10709 D17Mgh3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61059;61040 8201007;9685318 17 24748426 66698782 1 - by flanking markers 17 28967654 70289047 1 - by flanking markers F2 SS/Jr x LEW 10041 61104 SS/Jr LEW/NCrl 17 22775065 64946194 1 - by flanking markers 17 23080567 59555013 1 - by flanking markers 61395 rat Nka1 Natural killer alloreactivity QTL 1 4 natural killer cell cytolysis trait (VT:0005070) lymph node-specific lymphocyte tracer radioactivity level to kidney-specific lymphocyte tracer radioactivity level ratio (CMO:0001870) impaired natural killer cell mediated cytotoxicity autoimmune disease 61084;61085 9521051;8642329 60997 61006 DA PVG 61396 rat Bp9 Blood pressure QTL 9 10 4.8 1.0E-4 2493 Ace arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;61039;70857 1363813;7537756;9299556 2493 Ace 10 71443594 112200500 5 - by peak with adj size 10 72871396 110718848 5 - by peak with adj size F2 SS/Jr x MNS, LEW x SS/Jr, WKY x SS/Jr 10041 60992 SS/Jr MNS 10 71692298 112626471 5 - by peak with adj size 10 68420376 107211142 5 - by peak with adj size 61397 rat Bw17 Body weight QTL 17 7 6.3 24.0 10935 D7Wox14 10427 D7Wox19 10431 D7Wox18 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Body Weight Changes 61061;61082 8528248;8528247 Bw19 (maps to same region) 7 103159395 116152012 1 - by flanking markers 7 98955084 113044249 1 - by flanking markers intercross;F2 GK x BN 10017 60985 GK/KyoSwe BN 7 102588256 116249643 1 - by flanking markers 7 93595647 106839474 1 - by flanking markers 61398 rat Bp50 Blood pressure QTL 50 2 4.4 33727 D2Mit14 33763 D2Mit15 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61058 9329963 2 224018348 269018348 4 - by one flank marker only 2 197256223 242256223 4 - by one flank marker only F2 LH x LN 60990 61015 LH/MavRrrc LN/MavRrrc 2 204585642 249585642 4 - by one flank marker only 2 189599258 234599258 4 - by one flank marker only 61399 rat Tcat1 Tongue tumor resistance QTL 1 1 3.3 34037 D1Mit1 33959 D1Mit3 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879) decreased tongue tumor incidence Tongue Neoplasms 61091 9563479 1 117692800 162692800 4 - by one flank marker only 1 101971983 146971983 4 - by one flank marker only F1 DA/Slc x WF 61007 61111 WF DA/Slc 1 111446783 156446783 4 - by one flank marker only 1 99267916 144267916 4 - by one flank marker only 61400 rat Niddm1 Non-insulin dependent diabetes mellitus QTL 1 1 11.0 33945 D1Mit18 10805 D1Mgh13 33903 D1Mit7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance;increased body weight type 2 diabetes mellitus 61082;619689;2312611;61061 8528247;10720472;19697080;8528248 Bw83 (maps to same region);Gluco51 (maps to same region);Niddm7 (maps to same region) 1 246118980 274224361 1 - by flanking markers 1 224426266 252340527 1 - by flanking markers intercross;F2 GKxF344;GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 1 238830408 266793958 1 - by flanking markers 1 218753689 245907899 1 - by flanking markers 61401 rat Niddm2 Non-insulin dependent diabetes mellitus QTL 2 2 4.54 33763 D2Mit15 33727 D2Mit14 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance;increased circulating glucose level type 2 diabetes mellitus 61082;61061 8528247;8528248 Niddm8 (maps to same region) 2 179018437 224018437 4 - by one flank marker only 2 152256313 197256313 4 - by one flank marker only F2;intercross GKxF344;GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 2 159585731 204585731 4 - by one flank marker only 2 144599348 189599348 4 - by one flank marker only 61402 rat Niddm3 Non-insulin dependent diabetes mellitus QTL 3 10 4.58 34274 D10Mgh5 34445 D10Mgh6 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance;increased circulating glucose level type 2 diabetes mellitus 61082 8528247 10 63366218 85302342 1 - by flanking markers 10 67678060 86316831 1 - by flanking markers F2;intercross GKxF344;GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 10 64648311 85513822 1 - by flanking markers 10 61345413 82564856 1 - by flanking markers 61403 rat Niddm4 Non-insulin dependent diabetes mellitus QTL 4 1 11060 D1Wox23 33903 D1Mit7 43424 D1Wox10 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) abnormal pancreatic islet morphology;increased body weight type 2 diabetes mellitus 61083 9169130 1 232642738 262617374 1 - by flanking markers 1 212121314 240980321 1 - by flanking markers F2 13M x WKY;13MxWKY 61103 61112 WKY 13M 1 225689973 247836969 2 - by one flank and peak markers 1 206329708 222745518 2 - by one flank and peak markers 61404 rat Bw120 Body weight QTL 120 12 5.1 33961 D12Mit5 34373 D12Mgh6 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body weight;increased circulating glucose level type 2 diabetes mellitus 61083;61021;2312611 9169130;10051320;19697080 Bw88 (maps to same region) 12 16444048 54450796 4 - by one flank marker only 12 12770194 42387195 1 - by flanking markers F2 13M x WKY;13MxWKY 61103 61112 WKY 13M 12 14419775 52716770 4 - by one flank marker only 12 12351619 46669029 4 - by one flank marker only 61405 rat Niddm6 Non-insulin dependent diabetes mellitus QTL 6 16 3.66 0.001 33848 D16Mit2 43072 D16Rat116 33848 D16Mit2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 2 diabetes mellitus 61083;61021 9169130;10051320 16 4954192 51871168 1 - by flanking markers 16 4304396 52304351 1 - by flanking markers F2 13M x WKY;13MxWKY 61103 61112 WKY 13M 16 5013802 52144919 1 - by flanking markers 16 4227609 48972724 1 - by flanking markers 61406 rat Scwia1 Streptococcal cell wall induced arthritis QTL 1 4 2.3 42168 D4Arb30 10266 D4Arb4 61302 D4Arb24 joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint swelling Experimental Arthritis 61064;2307198;61073 10331011;18540828;10323205 3197;3834 Npy;Tcrb Aia3 (maps to same region);Cia3 (maps to same region);Eau1 (interacts with,maps to same region) 4 171606455 216606455 4 - by one flank marker only 4 73972453 154937227 1 - by flanking markers F2 LEWxF344 60999 70509 LEW F344/NRrrc 4 105682594 150682594 4 - by one flank marker only 4 106805662 151805662 4 - by one flank marker only 61407 rat Scl12 Serum cholesterol level QTL 12 19 0.001 2571 Ces1c 2535 Ednra 33802 D19Mit2 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating HDL cholesterol level familial hyperlipidemia 61079 8698878 19 26391608 44874904 1 - by flanking markers 19 14981499 32108153 1 - by flanking markers F2 SHR/OlaxBN-lx;SHR/Ola x BN-lx 61100 61113 SHR/Ola BN-Lx 19 15294524 33991703 1 - by flanking markers 19 13926401 30303727 1 - by flanking markers 61408 rat Scl23 Serum cholesterol level QTL 23 4 5.0E-4 2901 Il6 blood HDL phospholipid amount (VT:0010504) serum high density lipoprotein phospholipid level (CMO:0001567) increased circulating HDL cholesterol level familial hyperlipidemia 61079 8698878 4 1 25597824 5 - by peak with adj size 4 1 22959087 5 - by peak with adj size F2 SHR/Ola x BN-lx 61100 61113 SHR/Ola BN-Lx 4 1 25545519 5 - by peak with adj size 4 1 27716890 5 - by peak with adj size 61409 rat Scl13 Serum cholesterol level QTL 13 20 3.5E-4 61303 D20Utr1 blood HDL phospholipid amount (VT:0010504) serum high density lipoprotein phospholipid level (CMO:0001567) increased circulating HDL cholesterol level familial hyperlipidemia 61079 8698878 F2 SHR/Ola x BN-lx 61100 61113 SHR/Ola BN-Lx 61410 rat Bw19 Body weight QTL 19 7 6.2 0.001 10764 D7Mit23 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Body Weight Changes 61082 8528247 2868 Igf1 Bw17 (maps to same region) 7 6027519 51027519 5 - by peak with adj size 7 2030948 47030948 5 - by peak with adj size F2 GK x F344 10017 70509 GK/KyoSwe F344/NRrrc 7 5911477 50911477 5 - by peak with adj size 7 1 44782185 5 - by peak with adj size 61411 rat Pia1 Pristane induced arthritis QTL 1 20 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61088;61089;2300074;1582387;61031;61035;69708 8909256;9843218;18606636;16804090;10640775;9780220;10732705 Aia1 (interacts with);Coreg1 (maps to same region);Eae1 (maps to same region);Pia21 (maps to same region) intercross 60997 61013 DA E3 61412 rat Pia2 Pristane induced arthritis QTL 2 4 3.9 34200 D4Mgh1 35260 D4Rat22 34716 D4Mgh14 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) joint swelling Experimental Arthritis 61089;2307198;2300074;1582387;61031;61035 9843218;18540828;18606636;16804090;10640775;9780220 dominant Aia2 (maps to same region);Eae11 (maps to same region) 4 18184531 60769885 1 - by flanking markers 4 17617956 60974511 1 - by flanking markers F2;intercross E3 x DA 60997 61013 DA E3 4 18222187 61039065 1 - by flanking markers 4 21333343 62278020 1 - by flanking markers 61413 rat Eae10 Experimental allergic encephalomyelitis QTL 10 14 3.5 33551 D14Mit6 10135 D14Wox11 nervous system integrity trait (VT:0010566) percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 Pia6 (maps to same region) 14 19098434 19816468 1 - by flanking markers 14 19142085 19800225 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 14 19191664 19909740 1 - by flanking markers 14 17622685 18274498 1 - by flanking markers 61414 rat Pia3 Pristane induced arthritis QTL 3 6 4.5 33662 D6Mit1 36057 D6Rat4 44173 D6Wox5 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) joint swelling Experimental Arthritis 61089;728382;2307198;2300074;1582387 9843218;14611807;18540828;18606636;16804090 dominant 6 108684958 153719145 1 - by flanking markers 6 98840516 144200901 1 - by flanking markers intercross;F2 E3 x DA 60997 61013 DA E3 6 99273921 144792678 1 - by flanking markers 6 94968928 137848904 1 - by flanking markers 61415 rat Eae11 Experimental allergic encephalomyelitis QTL 11 4 2.9 11378 D4Wox30 34716 D4Mgh14 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 61031 10640775 Pia2 (maps to same region) 4 33498841 37534268 1 - by flanking markers 4 32648616 36592773 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 4 33637803 37685319 1 - by flanking markers 4 1 39505420 4 - by one flank marker only 61416 rat Pia4 Pristane induced arthritis QTL 4 12 8.4 44950 D12Wox5 35433 D12Rat17 11449 D12Wox14 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 61089;2300074;1582387;2307198;61073;2306769;2302026 9843218;18606636;16804090;18540828;10323205;19299744;14674011 additive Cia12 (maps to same region);Eae5 (maps to same region);Ean6 (maps to same region);Eau2 (interacts with);Pia12 (maps to same region);Pia38 (maps to same region) 12 17721341 37844419 1 - by flanking markers 12 568621 45568621 5 - by peak with adj size F2;intercross E3 x DA;E3xDA 60997 61013 DA E3 12 15714609 35964508 1 - by flanking markers 12 13635523 30827399 1 - by flanking markers 61417 rat Cia10 Collagen induced arthritis QTL 10 2 3.4 34461 D2Mgh12 joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint inflammation;joint swelling Experimental Arthritis 61063;61064;61065;2307198;2300074;1582387;2296064 9870869;10331011;10631556;18540828;18606636;16804090;18453595 2297;2310;2902;3205;3952;628704;1598328 Cd2;Cd53;Il6r;Nras;Vcam1;Il12b;Ngf additive Cia7 (interacts with);Eau5 (maps to same region) 2 213092797 258092797 5 - by peak with adj size 2 188136088 233136088 5 - by peak with adj size F2 DA/Bkl x ACI 10000 61114 ACI/N DA/Bkl 2 194998627 239998627 5 - by peak with adj size 2 179946951 224946951 5 - by peak with adj size 61418 rat Pia5 Pristane induced arthritis QTL 5 4 4.5 35260 D4Rat22 33933 D4Mit16 10561 D4Wox20 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61089;2307198;2300074;1582387;629560;61062 9843218;18540828;18606636;16804090;12571866;8782824 additive Aia3 (interacts with,maps to same region);Aia5 (maps to same region);Cia3 (interacts with,maps to same region) 4 60769721 192286332 1 - by flanking markers 4 60974346 130228614 1 - by flanking markers F2;intercross E3 x DA 60997 61013 DA E3 4 61038901 127777403 1 - by flanking markers 4 62277855 128289560 1 - by flanking markers 61419 rat Cia11 Collagen induced arthritis QTL 11 3 5.6 12.1 33862 D3Mit9 34228 D3Mgh5 11261 D3Wox9 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2307198;2300074;1582387 10857786;18540828;18606636;16804090 2237;2726;3439;3632 C5;Gpd2;Ptgs1;Scn2a 3 39535971 109733980 1 - by flanking markers 3 26674018 97524000 1 - by flanking markers F2;intercross DA/Bkl x BN/SsN 61114 61115 DA/Bkl BN/SsN 3 34394121 103141944 1 - by flanking markers 3 30356773 98535386 1 - by flanking markers 61420 rat Pia6 Pristane induced arthritis QTL 6 14 4.9 10622 D14Mgh3 11030 D14Mit4 35342 D14Rat8 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 61089;2300074;1582387;2307198;2298688;61031;2302026 9843218;18606636;16804090;18540828;18612083;10640775;14674011 recessive Eae10 (maps to same region);Gluco38 (maps to same region);Pia39 (maps to same region) 14 20172667 43777078 1 - by flanking markers 14 20165393 45020354 1 - by flanking markers F2;intercross E3 x DA 60997 61013 DA E3 14 20266223 43957628 1 - by flanking markers 14 18631345 42337007 1 - by flanking markers 61421 rat Cia12 Collagen induced arthritis QTL 12 12 4.6 10.2 44950 D12Wox5 41962 D12Arb6 10888 D12Wox10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2300074;1582387;2307198;61073;2302026;1285224 10857786;18606636;16804090;18540828;10323205;14674011;15334486 2621;3282;61306;61307;61308 Flt1;Pdgfa;Hspb1;Ncf1;Flt3 Cia25 (maps to same region);Eau2 (interacts with);Pia38 (maps to same region);Pia4 (maps to same region) 12 17721341 43150909 1 - by flanking markers 12 7148164 36894750 2 - by one flank and peak markers F2 DA/Bkl x BN/SsN 61114 61115 DA/Bkl BN/SsN 12 15714609 41291738 1 - by flanking markers 12 13635523 35682913 1 - by flanking markers 61422 rat Cia13 Collagen induced arthritis QTL 13 4 4.5 34001 D4Mit17 34338 D4Mgh11 33768 D4Mit14 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61067;61066;629560;2307198;2300074;1582387;61087 11001927;10857786;12571866;18540828;18606636;16804090;9600974 Ciaa4 (maps to same region);Oia2 (interacts with,maps to same region);Pia7 (maps to same region) 4 196943742 230565226 1 - by flanking markers 4 134858561 171204531 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 4 132455408 168047091 1 - by flanking markers 4 132642577 167139601 1 - by flanking markers 61423 rat Cia14 Collagen induced arthritis QTL 14 19 3.0 7.3 33951 D19Mit8 61309 D19Arb7 34033 D19Mit5 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2307198;2300074;1582387;2296064 10857786;18540828;18606636;16804090;18453595 Eau8 (maps to same region) 19 37325634 58687052 2 - by one flank and peak markers 19 24304442 45692656 2 - by one flank and peak markers F2 DA/Bkl x BN/SsN 61114 61115 DA/Bkl BN/SsN 19 11303927 47879277 1 - by flanking markers 19 10827970 43544039 1 - by flanking markers 61424 rat Scl1 Serum cholesterol level QTL 1 15 7.7 0.001 16.0 34453 D15Mgh7 2536 Ednrb 34353 D15Mgh2 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 15 22481747 91531979 1 - by flanking markers 15 18710622 87898700 1 - by flanking markers F2;intercross SHRSP/A3 x WKY 61116 631286 SHRSP/A3 WKY/Izm 15 18513913 88036354 1 - by flanking markers 15 16725528 80672115 1 - by flanking markers 61425 rat Cia15 Collagen induced arthritis QTL 15 9 4.6 35695 D9Rat44 42251 D9Arb7 34264 D9Mgh5 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2300074;1582387;2307198;61066 11001927;18606636;16804090;18540828;10857786 Ciaa3 (maps to same region) 9 2813697 47058352 1 - by flanking markers 9 2948882 39821284 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 9 2880977 47375681 1 - by flanking markers 9 5109826 42921101 1 - by flanking markers 61426 rat Scl2 Serum cholesterol level QTL 2 5 7.3 0.001 28.0 34322 D5Mgh10 34443 D5Mgh8 34041 D5Mit5 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 5 65595163 152732057 1 - by flanking markers 5 62098646 149757440 1 - by flanking markers F2;intercross SHRSP/A3 x WKY 61116 631286 SHRSP/A3 WKY/Izm 5 61086525 149030144 1 - by flanking markers 5 59793399 143070159 1 - by flanking markers 61427 rat Cia16 Collagen induced arthritis QTL 16 10 3.2 37464 D10Rat95 35256 D10Rat11 35449 D10Rat49 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2300074;1582387;2307198 11001927;18606636;16804090;18540828 10 5243736 99184250 1 - by flanking markers 10 6380753 100633982 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 10 6429075 99492409 1 - by flanking markers 10 6357896 96121100 1 - by flanking markers 61428 rat Scl3 Serum cholesterol level QTL 3 7 3.2 14.0 38334 D7Rat77 36442 D7Rat20 33729 D7Mit10 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 61092 10634822 7 98803811 134543261 1 - by flanking markers 7 95054656 132141292 1 - by flanking markers F2 SHRSP/A3 x WKY 61116 631286 SHRSP/A3 WKY/Izm 7 53200344 98200344 4 - by one flank marker only 7 44867533 89867533 4 - by one flank marker only 61429 rat Cia17 Collagen induced arthritis QTL 17 18 4.6 10689 D18Mit5 41356 D18Rat82 41356 D18Rat82 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 18 32348154 72695235 1 - by flanking markers 18 32458819 73666623 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 18 32670352 73016546 1 - by flanking markers 18 31359408 70263868 1 - by flanking markers 61430 rat Cia18 Collagen induced arthritis QTL 18 X 3.1 45715 DXWox2 43947 DXWox3 45715 DXWox2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 Cia19 (maps to same region) X 16479345 127983061 1 - by flanking markers X 4384157 49384157 5 - by peak with adj size F2 BB/DRxBN 10003 60985 BBDR/Rhw BN X 15688119 127888215 1 - by flanking markers X 14843113 120568734 1 - by flanking markers 61431 rat Cia19 Collagen induced arthritis QTL 19 X 4.4 34192 DXMgh9 43947 DXWox3 34991 DXRat66 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 Cia18 (maps to same region) X 71224072 127983061 1 - by flanking markers X 1 88514313 2 - by one flank and peak markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN X 70352120 127888215 1 - by flanking markers X 65612192 120568734 1 - by flanking markers 61432 rat Cia1 Collagen induced arthritis QTL 1 20 11428 D20Wox3 40318 D20Rat60 11428 D20Wox3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61062;2300074;1582387;2307198;61067;61066;61035;69708 8782824;18606636;16804090;18540828;11001927;10857786;9780220;10732705 Aia1 (interacts with);Ciaa1 (interacts with);Coreg1 (maps to same region) 20 6935875 17237454 1 - by flanking markers 20 3660646 14605852 1 - by flanking markers F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 20 4855475 15050565 1 - by flanking markers 20 3621656 14101050 1 - by flanking markers 61433 rat Cia2 Collagen induced arthritis QTL 2 1 5.0 42083 D1Arb37 10335 D1Arb36 39312 D1Rat212 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61062;61068;2300074;1582387;2307198;61067;2302026 8782824;9692888;18606636;16804090;18540828;11001927;14674011 3852;61310 Tgfbr1;Pkrcg Pia36 (maps to same region) 1 80946391 96008597 1 - by flanking markers 1 33153323 78153323 4 - by one flank marker only F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 1 79689765 94909507 1 - by flanking markers 1 78430754 91209302 1 - by flanking markers 61434 rat Cia3 Collagen induced arthritis QTL 3 4 4.8 10562 D4Arb21 61302 D4Arb24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61062;61068;2300074;1582387;2307198;61073;629560;2306769;61064;61087;61089 8782824;9692888;18606636;16804090;18540828;10323205;12571866;19299744;10331011;9600974;9843218 Aia3 (interacts with,maps to same region);Aia5 (maps to same region);Ean2 (maps to same region);Eau1 (maps to same region);Oia2 (maps to same region);Pia5 (maps to same region,interacts with);Scwia1 (maps to same region) 4 163843971 208843971 4 - by one flank marker only 4 104415843 149415843 4 - by one flank marker only F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 4 99066823 144066823 4 - by one flank marker only 4 103194656 148194656 4 - by one flank marker only 61435 rat Cia4 Collagen induced arthritis QTL 4 7 5.3 10221 D7Arb17 34999 D7Rat44 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis;Experimental Arthritis 61069;61062;61068;1599708;2300074;1582387;2307198;61067 10398805;8782824;9692888;17277140;18606636;16804090;18540828;11001927 2896;3285 Il2rb;Pdgfrb recessive Cia8 (interacts with) 7 67533138 69590450 1 - by flanking markers 7 62224456 66202126 1 - by flanking markers F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 7 67346146 69399731 1 - by flanking markers 7 58113224 62004598 1 - by flanking markers 61436 rat Cia5 Collagen induced arthritis QTL 5 10 4.9 2686 Gh1 61275 D10Arb22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61062;61068;1642451;2300074;1582387;61067;61073;631168;625379;69693;61519 8782824;9692888;17673937;18606636;16804090;11001927;10323205;11003387;11953987;10087293 3395;61312 Prkca;Timp2 Aia5 (interacts with);Cari1 (maps to same region);Cia20 (maps to same region,interacts with);Cia21 (interacts with,maps to same region);Cia22 (interacts with,maps to same region);Cia23 (interacts with,maps to same region);Eau3 (maps to same region);Pia10 (maps to same region) 10 94237414 107484761 1 - by flanking markers 10 95692240 110718848 4 - by one flank marker only F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 10 94486204 107857673 1 - by flanking markers 10 91228102 104060283 1 - by flanking markers 61437 rat Cia6 Collagen induced arthritis QTL 6 8 34310 D8Mgh4 38898 D8Rat71 34068 D8Mgh11 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61067;1599708;2307198;2300074;1582387 11001927;17277140;18540828;18606636;16804090 8 88595396 131397435 1 - by flanking markers 8 86627869 127907359 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 8 89058229 132243842 1 - by flanking markers 8 82460758 122812818 1 - by flanking markers 61438 rat Cia7 Collagen induced arthritis QTL 7 2 4.6 1.0E-4 20.0 11156 D2Mit24 33983 D2Mit23 33674 D2Mit17 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis;Experimental Arthritis 61067;61063;2307198;2300074;1582387;1285224 11001927;9870869;18540828;18606636;16804090;15334486 2391 Cpb1 dominant Cia10 (interacts with);Cia26 (interacts with) 2 84360871 166931968 1 - by flanking markers 2 59700886 146659672 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 2 60325352 147522851 1 - by flanking markers 2 59324377 141596857 1 - by flanking markers 61439 rat Cia8 Collagen induced arthritis QTL 8 7 5.1 36422 D7Rat26 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61069;2307198 10398805;18540828 Cia4 (interacts with) F2 DA/Bkl x F344/NHsd 61109 61114 F344/NHsd DA/Bkl 7 32572942 77572942 5 - by peak with adj size 61440 rat Cia9 Collagen induced arthritis QTL 9 Y joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint inflammation;joint swelling Experimental Arthritis 61064;61065;61063 10331011;10631556;9870869 F2 DA/Bkl x ACI 10000 61114 ACI/N DA/Bkl 61441 rat Btemp1 Thermal response to stress QTL 1 10 4.0 52.0 33846 D10Mit2 33909 D10Mit4 3138 Myh3 body temperature trait (VT:0005535) core body temperature (CMO:0001036) increased body temperature;increased response to stress-induced hyperthermia Body Temperature Changes 61094 10679499 10 36354916 65628115 1 - by flanking markers 10 36650094 64860949 1 - by flanking markers SHR/Ola x BN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 10 36584560 66015527 1 - by flanking markers 10 35392457 63642539 1 - by flanking markers 61442 rat Strs1 Sensitivity to stroke QTL 1 1 7.4 33959 D1Mit3 cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) brain ischemia Stroke 61093;2307158;11040448;7411685 8696337;16835352;25084306;23690346 Strs4 (maps to same region) 1 140192506 185192506 5 - by peak with adj size 1 124471914 169471914 5 - by peak with adj size F2 SHRSP x SHR 1581618 7241794 SHRSP/Bbb SHR/Bbb 1 133946489 178946489 5 - by peak with adj size 1 121767634 166767634 5 - by peak with adj size 61443 rat Btemp2 Thermal response to stress QTL 2 12 3.3 9.4E-5 61306 Hspb1 33725 D12Mit1 10878 D12Wox9 body temperature trait (VT:0005535) core body temperature (CMO:0001036) increased body temperature;increased response to stress-induced hyperthermia Body Temperature Changes 61094 10679499 12 19102374 25837102 1 - by flanking markers 12 15508819 21911223 1 - by flanking markers SHR/Ola x BN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 12 17114770 23839390 1 - by flanking markers 12 15025183 20794014 1 - by flanking markers 61444 rat Strs2 Sensitivity to stroke QTL 2 5 4.7 3193 Nppa cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) brain ischemia Stroke 61093;731210 8696337;14678232 Bp155 (maps to same region) 5 145966963 177180328 5 - by peak with adj size 5 142575172 173096209 5 - by peak with adj size F2 SHRSP x SHR 1581618 7241794 SHRSP/Bbb SHR/Bbb 5 142309061 173707219 5 - by peak with adj size 5 135929696 166875058 5 - by peak with adj size 61445 rat Strs3 Sensitivity to stroke QTL 3 4 3.0 10144 D4Mgh16 cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) brain ischemia Stroke 61093 8696337 4 38927545 83927545 5 - by peak with adj size 4 39146794 84146794 5 - by peak with adj size F2 SHRSP x SHR 1581618 7241794 SHRSP/Bbb SHR/Bbb 4 39208222 84208222 5 - by peak with adj size 4 40433388 85433388 5 - by peak with adj size 61446 rat Coreg2 Compensatory renal growth QTL 2 4 3.5 54.0 3371 Pparg 2554 Eno2 61315 D4Cebr7s17 kidney mass (VT:0002707) compensatory renal growth score (CMO:0001894) increased compensatory renal growth kidney disease 61071 10864582 2245 Cacna1c 4 210562928 224311673 1 - by flanking markers 4 151492220 160897723 1 - by flanking markers F2 SHR/Ola x BN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 4 147274055 157294090 1 - by flanking markers 4 148423102 157580971 1 - by flanking markers 61447 rat Tcas1 Tongue tumor susceptibility QTL 1 19 6.08 11471 D19Mit9 tongue integrity trait (VT:0010553) squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875) increased tongue tumor incidence Tongue Neoplasms 61091;1358147 9563479;15876484 2503 Nqo1 Tcas7 (sub_region) 19 12935711 57935711 5 - by peak with adj size 19 4034890 49034890 5 - by peak with adj size F1 DA/Slc x WF 61007 61111 WF DA/Slc 19 1957707 46957707 5 - by peak with adj size 19 2316121 47316121 5 - by peak with adj size 61448 rat Ciaa1 CIA Autoantibody QTL 1 20 30.0 0.001 11206 D20Arb2 61316 D20Arb8 11428 D20Wox3 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) increased IgG level;joint inflammation Experimental Arthritis;Experimental Arthritis 61066;61067;61062;2307198;2300074;1582387;61035 10857786;11001927;8782824;18540828;18606636;16804090;9780220 Aia1 (interacts with,maps to same region);Cia1 (interacts with);Oia1 (maps to same region) 20 5249981 8621883 2 - by one flank and peak markers 20 2790511 4530895 2 - by one flank and peak markers F2 DAxF344, DAxBN, BB/DRxBN 60985 60997 BN DA 20 3151815 6896013 2 - by one flank and peak markers 20 2646395 4597031 2 - by one flank and peak markers 61449 rat Ciaa2 CIA Autoantibody QTL 2 10 7.1 10142 D10Arb9 10641 D10Wox22 10642 D10Mit12 blood autoantibody amount (VT:0003725) calculated serum anti-type 2 collagen antibody titer (CMO:0001279) increased IgG level;joint inflammation Experimental Arthritis;Experimental Arthritis 61518;61066;2300074;1582387;2307198 10857786;18606636;16804090;18540828 2836;3773;3774;3877;1594396 Hsd17b1;Stat5a;Stat5b;Tnfaip1;Trim25 10 66048908 94240491 1 - by flanking markers 10 64308668 95695218 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 10 65590122 110590122 4 - by one flank marker only 10 63221094 107211142 4 - by one flank marker only 61450 rat Ciaa3 CIA Autoantibody QTL 3 9 6.5 44567 D9Wox19 60827 D9Wox23 60827 D9Wox23 blood autoantibody amount (VT:0003725) calculated serum anti-type 2 collagen antibody titer (CMO:0001279) increased IgG level;joint inflammation Experimental Arthritis 61066;61067;2300074;1582387;2307198 10857786;11001927;18606636;16804090;18540828 2232;3951 C3;Vav1 recessive Cia15 (maps to same region) 9 4772291 24554173 1 - by flanking markers 9 18347567 63347567 4 - by one flank marker only F2;intercross (DAxBN)F1 x (BNxDA)F1, and others 60985 60997 BN DA 9 5724254 25692342 1 - by flanking markers 9 7954720 22071169 1 - by flanking markers 61451 rat Ciaa4 CIA Autoantibody QTL 4 4 3.1 34256 D4Mgh18 34338 D4Mgh11 33768 D4Mit14 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) increased IgG level Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 2306;61318;61319;61320;621237 Cd4;Cd69;Tnfrsf7;Kird1;Tnfrsf1a Cia13 (maps to same region);Oia2 (maps to same region) 4 190397443 230565226 1 - by flanking markers 4 128179957 171204531 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 4 125884464 168047091 1 - by flanking markers 4 126395976 167139601 1 - by flanking markers 61452 rat Ciaa5 CIA Autoantibody QTL 5 5 3.5 43928 D5Wox3 34443 D5Mgh8 34220 D5Mgh13 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) increased IgG level Experimental Arthritis 61067;2307198;2300074;1582387 11001927;18540828;18606636;16804090 2943 Jun 5 101964092 152732057 1 - by flanking markers 5 99080786 149757440 1 - by flanking markers F2 BB/DRxBN 10003 60985 BBDR/Rhw BN 5 97921932 149030144 1 - by flanking markers 5 94858972 143070159 1 - by flanking markers 61453 rat Pur1 Proteinuria QTL 1 13 18.06 34371 D13Mgh3 34351 D13Mgh4 urine total protein amount (VT:0000032) urine protein level (CMO:0000591) increased urine protein level proteinuria 619599;2292230 9799838;18064521 Pur16 (sub_region) 13 44494434 47416214 1 - by flanking markers 13 35472372 38489943 1 - by flanking markers (BUF/Mna x WKY/NCrj) x BUF/Mna backcross BUF/Mna x WKY/NCrj 61118 61119 BUF/Mna WKY/NCrlCrlj 13 39372927 42310885 1 - by flanking markers 13 34535218 37415726 1 - by flanking markers 61455 rat Niddm7 Non-insulin dependent diabetes mellitus QTL 7 1 5.5 16.0 43424 D1Wox10 2470 Cyp2c12 43424 D1Wox10 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 61061;619689;2312611 8528248;10720472;19697080 2870;3786 Igf2;Abcc8 Bw83 (maps to same region);Gluco51 (maps to same region);Niddm1 (maps to same region) 1 244066294 266215677 1 - by flanking markers 1 198139596 243139596 5 - by peak with adj size F2;intercross GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 1 236763415 258766873 1 - by flanking markers 1 214537555 238757011 1 - by flanking markers 61457 rat Niddm8 Non-insulin dependent diabetes mellitus QTL 8 2 4.1 0.01 12.0 3336 Pklr 3195 Npr1 11048 D2Wox23 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level type 2 diabetes mellitus 61061;2313613 8528248;19575795 Niddm2 (maps to same region) 2 207865529 209287892 1 - by flanking markers 2 181214853 182740242 1 - by flanking markers F2 GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 2 188449158 189857032 1 - by flanking markers 2 174543008 175950118 1 - by flanking markers 61458 rat Bp10 Blood pressure QTL 10 2 3.42 2167 Atp1a1 2263 Camk2d 2167 Atp1a1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;61038;619639;70380;61045;728179 1363813;8040284;7768551;11773968;9132270;11980293 3195 Npr1 Bp14 (maps to same region,interacts with);Bp16 (maps to same region);Bp19 (interacts with);Bp36 (interacts with);Bp73 (interacts with) 2 223440514 250484590 1 - by flanking markers 2 196657749 224108082 1 - by flanking markers F2 SS/JrxWKY 10041 61103 SS/Jr WKY 2 204003742 231132207 1 - by flanking markers 2 189020722 215287351 1 - by flanking markers 61460 rat Niddm9 Non-insulin dependent diabetes mellitus QTL 9 4 3.4 1.0E-4 10.0 60802 D4Wox3 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level type 2 diabetes mellitus 61061 8528248 F2;intercross GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 61461 rat Bp11 Blood pressure QTL 11 13 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;6892692;61057;61043;61046 1363813;22434847;7981757;8952608;8567976 Bp24 (interacts with,maps to same region);Bp25 (interacts with);Bp31 (interacts with,maps to same region);Bp5 (interacts with,maps to same region) F2 60992 61103 MNS WKY 61462 rat Niddm10 Non-insulin dependent diabetes mellitus QTL 10 5 3.9 0.001 11.0 43870 D5Wox8 34639 D5Pas1 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 61061 8528248 5 4498411 57407155 2 - by one flank and peak markers 5 4291144 49586522 2 - by one flank and peak markers F2;intercross GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 5 4525738 47978104 2 - by one flank and peak markers 5 5112159 47171491 2 - by one flank and peak markers 61463 rat Bp12 Blood pressure QTL 12 10 6.3 1.0E-4 3185 Nos2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61037;61039;61040 1363813;7537756;9685318 3185 Nos2 10 42940291 87940291 5 - by peak with adj size 10 42554668 87554668 5 - by peak with adj size F2 SS/Jr x LEW, SR/Jr x LEW 10041 60992 SS/Jr MNS 10 43704955 88704955 5 - by peak with adj size 10 41333258 86333258 5 - by peak with adj size 61464 rat Niddm11 Non-insulin dependent diabetes mellitus QTL 11 8 3.1 0.001 10.0 10168 D8Wox5 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level type 2 diabetes mellitus 61061;2312611 8528248;19697080 Insul13 (maps to same region) 8 39734981 84734981 5 - by peak with adj size intercross;F2 GKxBN;GK x BN 10017 60985 GK/KyoSwe BN 8 39958022 84958022 5 - by peak with adj size 8 35582032 80582032 5 - by peak with adj size 61465 rat Bp13 Blood pressure QTL 13 2 3.3 33620 D2Mit6 2391 Cpb1 33620 D2Mit6 blood pressure trait (VT:0000183) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61041;68910 8901842;10642295 Bp132 (maps to same region);Bp6 (maps to same region) 2 98037122 124850792 1 - by flanking markers 2 77630629 105443909 1 - by flanking markers F2;backcross SHRSP x WKY 734759 734760 SHRSP/Gcrc WKY/Gcrc 2 78321410 105089682 1 - by flanking markers 2 76539322 102785628 1 - by flanking markers 61466 rat Niddm12 Non-insulin dependent diabetes mellitus QTL 12 17 3.2 0.001 11.0 10350 D17Wox12 45485 D17Wox9 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased body weight;increased circulating glucose level type 2 diabetes mellitus 61061 8528248 17 62181621 65757413 2 - by one flank and peak markers 17 60586065 71214851 2 - by one flank and peak markers F2;intercorss GK x BN;GKxBN 10017 60985 GK/KyoSwe BN 17 60397177 63994347 2 - by one flank and peak markers 17 54029929 60463637 2 - by one flank and peak markers 61467 rat Bp14 Blood pressure QTL 14 2 2.2 34461 D2Mgh12 34278 D2Mgh14 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61041;631154;1643008;7401270;728179;68910;61045;61038 8901842;12624007;17938382;23648703;11980293;10642295;9132270;8040284 Bp10 (interacts with,maps to same region);Bp132 (maps to same region);Bp16 (interacts with);Bp166 (maps to same region);Bp19 (maps to same region) 2 62179292 235592715 1 - by flanking markers 2 42866342 210636008 1 - by flanking markers F2;backcross SHRSP x WKY 734759 734760 SHRSP/Gcrc WKY/Gcrc 2 43133606 217498545 1 - by flanking markers 2 43154682 202446871 1 - by flanking markers 61468 rat Bp15 Blood pressure QTL 15 3 4.4 34347 D3Mgh16 blood pressure trait (VT:0000183) diastolic blood pressure (CMO:0000005);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61041;1302893 8901842;15452030 recessive 3 1 33861758 5 - by peak with adj size 3 1 28873394 5 - by peak with adj size F2 SHRSP x WKY 734759 734760 SHRSP/Gcrc WKY/Gcrc 3 1 28500807 5 - by peak with adj size 3 1 33278763 5 - by peak with adj size 61469 rat Bp16 Blood pressure QTL 16 2 5.64 60797 D2Wox7 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 61043;61045;728179;619639 8952608;9132270;11980293;7768551 2167 Atp1a1 Bp10 (maps to same region);Bp14 (interacts with);Bp19 (interacts with) 2 204149709 249149709 5 - by peak with adj size 2 177484675 222484675 5 - by peak with adj size F2 SHRxWKY 61000 61103 SHR WKY 2 184730446 229730446 5 - by peak with adj size 2 169745596 214745596 5 - by peak with adj size 61471 rat Bp18 Blood pressure QTL 18 2 3.0 3119 Mt1-ps2 34278 D2Mgh14 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;2306880 9132270;19126752 Bp336 (maps to same region) 4 203187690 248187690 4 - by one flank marker only 2 11261631 42866342 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 61472 rat Aia1 Adjuvant induced arthritis QTL 1 20 18.0 0.001 11206 D20Arb2 61316 D20Arb8 11428 D20Wox3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61035;2307198;2300074;1582387;69708;61066 9780220;18540828;18606636;16804090;10732705;10857786 Cia1 (interacts with);Ciaa1 (interacts with,maps to same region);Coreg1 (maps to same region);Oia1 (interacts with);Pia1 (interacts with) 20 5249981 8621883 2 - by one flank and peak markers 20 2790511 4530895 2 - by one flank and peak markers F2 DAxF344 60997 70509 DA F344/NRrrc 20 3151815 6896013 2 - by one flank and peak markers 20 2646395 4597031 2 - by one flank and peak markers 61473 rat Bp19 Blood pressure QTL 19 2 6.3 34292 D2Mgh8 3195 Npr1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61045;2306880;70380;728179;619639 9132270;19126752;11773968;11980293;7768551 Bp10 (interacts with);Bp14 (maps to same region);Bp16 (interacts with);Bp337 (maps to same region);Bp73 (interacts with) 2 206015127 209287892 1 - by flanking markers 2 179302449 182740242 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 2 186611811 189857032 1 - by flanking markers 2 172710921 175950118 1 - by flanking markers 61474 rat Eae1 Experimental allergic encephalomyelitis QTL 1 20 3.0 37594 D20Rat41 34280 D20Mgh4 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) paresis Experimental Autoimmune Encephalomyelitis 61031 10640775 Pia1 (maps to same region) 20 6118659 7910747 1 - by flanking markers 20 4740609 6880472 1 - by flanking markers F2 E3 x DA 60997 61013 DA E3 20 4039113 5875448 1 - by flanking markers 20 4606607 6691706 1 - by flanking markers 61475 rat Aia2 Adjuvant induced arthritis QTL 2 4 5.8 42158 D4Arb26 42168 D4Arb30 34282 D4Mgh15 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation;joint swelling Experimental Arthritis 61035;629560;2300074;1582387;2307198 9780220;12571866;18606636;16804090;18540828 Eau1 (interacts with);Iddm4 (interacts with);Pia2 (maps to same region) 4 37534124 72703184 2 - by one flank and peak markers 4 36592628 73972591 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 4 37685175 73066691 2 - by one flank and peak markers 4 39505275 73892441 2 - by one flank and peak markers 61476 rat Aia3 Adjuvant induced arthritis QTL 3 4 3.9 42168 D4Arb30 10158 D4Arb16 61302 D4Arb24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61035;629560;2300074;1582387;2307198;61073;61064;61089;61062 9780220;12571866;18606636;16804090;18540828;10323205;10331011;9843218;8782824 3197;3834 Npy;Tcrb Cia3 (interacts with,maps to same region);Eau1 (maps to same region);Pia5 (maps to same region,interacts with);Scwia1 (maps to same region) 4 151024194 196024194 4 - by one flank marker only 4 73972453 133939659 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 4 86532519 131532519 4 - by one flank marker only 4 86730991 131730991 4 - by one flank marker only 61477 rat Aia4 Adjuvant induced arthritis QTL 4 15 3.0 33820 D15Mit6 34471 D15Mgh3 35230 D15Rat22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61035;2307198;2300074;1582387 9780220;18540828;18606636;16804090 15 66251142 102837144 1 - by flanking markers 15 61458810 99039586 1 - by flanking markers F2 DAxF344 60997 70509 DA F344/NRrrc 15 62596410 99372139 1 - by flanking markers 15 55596089 91365858 1 - by flanking markers 70153 rat Bp59 Blood pressure QTL 59 14 3.2 40852 D14Rat90 41138 D14Rat94 2041 Add1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 2041 Add1 14 73407669 88669930 1 - by flanking markers 14 73956596 89192873 1 - by flanking markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 14 73391467 88870994 1 - by flanking markers 14 68757796 83368335 1 - by flanking markers 70154 rat Insul2 Insulin level QTL 2 20 3.75 33563 D20Mit5 34280 D20Mgh4 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) decreased circulating insulin level type 2 diabetes mellitus 70067;69703 9819774 20 7910747 20898221 1 - by flanking markers 20 6880472 18245770 1 - by flanking markers F2 F344xOLETF 70509 734526 F344/NRrrc OLETF/Got 20 5875448 18739210 1 - by flanking markers 20 6691706 17489458 1 - by flanking markers 70155 rat Gcs1 Gastric cancer susceptibility QTL1 15 3.8 36602 D15Rat29 34357 D15Mgh4 40106 D15Rat102 stomach morphology trait (VT:0000470) stomach tumor susceptibility score (CMO:0002043) increased incidence of induced tumors Stomach Neoplasms 69698 10706129 15 87456591 114627140 2 - by one flank and peak markers 15 83349477 108387242 1 - by flanking markers (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 15 83947714 111246239 2 - by one flank and peak markers 15 76306099 101769107 2 - by one flank and peak markers 70156 rat Niddm30 Non-insulin dependent diabetes mellitus QTL 30 5 3.98 34581 D5Mgh27 34168 D5Mgh22 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance 70067;69696;7207431;2312611 10594234;23118743;19697080 Gluco52 (maps to same region) 5 138292963 160953783 1 - by flanking markers 5 135910738 157584492 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 5 134502140 157212422 1 - by flanking markers 5 129132447 151006154 1 - by flanking markers 70157 rat Niddm32 Non-insulin dependent diabetes mellitus QTL 32 17 4.34 2532 Edn1 34120 D17Mgh5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696 10594234 17 24117499 51171794 1 - by flanking markers 17 28303886 59104944 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 17 22136814 53475276 1 - by flanking markers 17 22454924 50909196 1 - by flanking markers 70158 rat Bp60 Blood pressure QTL 60 20 3.0 38216 D20Rat22 37570 D20Rat38 38762 D20Rat40 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 20 35134762 47429142 1 - by flanking markers 20 30941362 36641808 2 - by one flank and peak markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 20 33354783 45719230 1 - by flanking markers 20 31614284 44396023 1 - by flanking markers 70159 rat Bp61 Blood pressure QTL 61 7 1.0E-4 62494 D7Uia1 33816 D7Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69709;69710;69711;619653 7981756;9383281;11247666;11161799 2453 Cyp11b1 Bp169 (maps to same region) 7 112367543 126236887 1 - by flanking markers 7 108875615 123635849 1 - by flanking markers F2 SxR 10040 10041 SR/Jr SS/Jr 7 112429186 126525386 1 - by flanking markers 7 103146217 116738842 1 - by flanking markers 70160 rat Bw18 Body weight QTL 18 1 5.7 33959 D1Mit3 3643 Sct body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69701;619689 9530625;10720472 Bw83 (maps to same region) 1 162692213 221191992 1 - by flanking markers 1 146971846 201472944 1 - by flanking markers F1xSHR (BB/OKxSHR)F1xSHR 61107 61110 BB/OK SHR/Mol 1 156446196 214277437 1 - by flanking markers 1 144267353 196383668 1 - by flanking markers 70161 rat Bp62 Blood pressure QTL 62 8 2.9 0.001 13.5 33887 D8Mit3 40168 D8Rat133 35014 D8Rat24 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;61516 11015598 dominant 8 45061464 96501839 1 - by flanking markers 8 45291674 94514282 1 - by flanking markers F2;intercross SxSHR;SS/JrxSHR 10041 724574 SS/Jr SHR/NHsd 8 46588437 96998640 1 - by flanking markers 8 42692684 90165460 1 - by flanking markers 70162 rat Bp63 Blood pressure QTL 63 2 5.64 60797 D2Wox7 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 70067;61043 8952608 2 204149709 249149709 5 - by peak with adj size 2 177484675 222484675 5 - by peak with adj size F2 SHRxWKY 61000 61103 SHR WKY 2 184730446 229730446 5 - by peak with adj size 2 169745596 214745596 5 - by peak with adj size 70163 rat Bw20 Body weight QTL 20 1 5.1 62086 Acsm3 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69701 9530625 1 196449042 270717037 1 - by flanking markers 1 178054386 247322277 1 - by flanking markers F1xSHR SHRx(BB/OKxSHR)F1 61107 61110 BB/OK SHR/Mol 1 189514504 234514504 4 - by one flank marker only 1 174133260 219133260 4 - by one flank marker only 70164 rat Bw21 Body weight QTL 21 10 4.36 5.0E-5 11.9 44839 D10Wox7 11479 D10Mit8 3385 Ppy body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69691;625760 9824537;12420133 10 55422144 102101261 1 - by flanking markers 10 55851811 103550924 1 - by flanking markers F2;intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 10 55679084 102427604 1 - by flanking markers 10 53797494 98952626 1 - by flanking markers 70165 rat Bp64 Blood pressure QTL 64 X 5.2 7.2 34559 DXMgh12 35030 DXRat2 36111 DXRat8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69713 9931114 X 2456588 33791311 1 - by flanking markers X 30326177 52447691 2 - by one flank and peak markers F2 SBHxSBN 631572 631573 SBH/Ygl SBN/Ygl X 1662609 33443848 1 - by flanking markers X 1448129 31706553 1 - by flanking markers 70166 rat Bp65 Blood pressure QTL 65 X 5.8 7.5 35030 DXRat2 36474 DXRat4 36474 DXRat4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69713 9931114 X 2456432 13162713 1 - by flanking markers X 994805 45994805 5 - by peak with adj size F2 SBHxSBN 631572 631573 SBH/Ygl SBN/Ygl X 1662453 12370298 1 - by flanking markers X 1447972 11374346 1 - by flanking markers 70167 rat Bw22 Body weight QTL 22 4 3.1 60732 D4Mit6 3753 Spr 11015 D4Mit24 body mass (VT:0001259) body weight (CMO:0000012) obese Body Weight Changes 70067;69707 9530522 4 141978848 181496612 1 - by flanking markers 4 75732943 119369308 1 - by flanking markers (BB/OKxSHR)F1xBB/OK 61107 61110 BB/OK SHR/Mol 4 77307388 116916073 1 - by flanking markers 4 76647384 117676292 1 - by flanking markers 70168 rat Eae12 Experimental allergic encephalomyelitis QTL 12 10 9.0E-4 34941 D10Rat7 36283 D10Rat15 34100 D10Mgh3 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) abnormal inflammatory response;demyelination;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 10 95243104 103956674 1 - by flanking markers 10 96667338 105886241 1 - by flanking markers F2 DAxACI 10000 60997 ACI/N DA 10 95508221 104329177 1 - by flanking markers 10 92238497 101012337 1 - by flanking markers 70169 rat Eae13 Experimental allergic encephalomyelitis QTL 13 12 0.032 36671 D12Rat19 36025 D12Rat23 36490 D12Rat18 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) demyelination;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 12 29163190 44046371 1 - by flanking markers 12 25367251 37906389 1 - by flanking markers F2 DAxACI 10000 60997 ACI/N DA 12 27190240 42196641 1 - by flanking markers 12 24139202 36638073 1 - by flanking markers 70170 rat Eae14 Experimental allergic encephalomyelitis QTL 14 13 0.0024 36069 D13Rat23 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) abnormal inflammatory response;demyelination;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 13 33639787 78639787 5 - by peak with adj size 13 24701710 69701710 5 - by peak with adj size F2 DAxACI 10000 60997 ACI/N DA 13 28584452 73584452 5 - by peak with adj size 13 23203448 68203448 5 - by peak with adj size 70171 rat Cari1 Carrageenan-induced inflammation QTL 1 10 4.9 5.0E-4 18.0 33941 D10Mit11 11479 D10Mit8 34274 D10Mgh5 hypodermis integrity trait (VT:0010550) inflammatory exudate volume (CMO:0001429) abnormal inflammatory response Acute-Phase Reaction;Inflammation 70067;69693;69694;61073 10087293;9973459;10323205 dominant Aia5 (interacts with);Cia5 (maps to same region);Eau3 (interacts with) 10 55422036 112200500 2 - by one flank and peak markers 10 55851811 101848470 1 - by flanking markers F2 F344xLEW 60999 70509 LEW F344/NRrrc 10 55678976 112626471 2 - by one flank and peak markers 10 53797385 107211142 2 - by one flank and peak markers 70172 rat Eae15 Experimental allergic encephalomyelitis QTL 15 18 0.001 34290 D18Mgh4 33814 D18Mit9 33715 D18Mit6 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) demyelination;increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69695 10545597 18 79012526 79748387 1 - by flanking markers 18 79585008 80370517 1 - by flanking markers F2 DAxACI 10000 60997 ACI/N DA 18 79948616 80696375 1 - by flanking markers 18 76477814 77209844 1 - by flanking markers 70173 rat Niddm19 Non-insulin dependent diabetes mellitus QTL 19 7 4.33 5.0E-5 34132 D7Mgh18 60819 D7Wox3 44295 D7Wox6 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance;impaired glucose tolerance type 2 diabetes mellitus 70067;69691;69696;625760;1643009;7207431;2312611 9824537;10594234;12420133;17710484;23118743;19697080 Gluco53 (maps to same region) 7 71619460 143501887 2 - by one flank and peak markers 7 68162496 143002779 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 1302654 F344.OLETF-(D7Mgh16-D7Mgh20)/Tj 7 71448715 145729302 2 - by one flank and peak markers 7 64002457 135012528 2 - by one flank and peak markers 70174 rat BpQTLCluster2 Blood pressure QTL cluster 2 2 4.24 34397 D2Mgh2 2391 Cpb1 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 2 59248567 124850792 1 - by flanking markers 2 39828973 105443909 1 - by flanking markers F2 LHxLN 60990 61015 LH/MavRrrc LN/MavRrrc 2 40171834 105089682 1 - by flanking markers 2 40067944 102785628 1 - by flanking markers 70175 rat BpQTLCluster3 Blood pressure QTL cluster 3 2 4.128 34461 D2Mgh12 34497 D2Mgh24 arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 2 160041016 235592715 1 - by flanking markers 2 140403692 210636008 1 - by flanking markers F2 SHRxWKY 61000 61103 SHR WKY 2 140566078 217498545 1 - by flanking markers 2 135552573 202446871 1 - by flanking markers 70176 rat Mcsm1 Mammary carcinoma susceptibility modifier QTL 1 6 33993 D6Mit2 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417 11139513 6 71775541 116775541 5 - by peak with adj size 6 61787263 106787263 5 - by peak with adj size 61105 737908 WKY/NHsd WF/NHsd 6 62263348 107263348 5 - by peak with adj size 6 58632962 103632962 5 - by peak with adj size 70177 rat Xhs1 X-ray hypersensitivity QTL 1 4 25.1 41200 D4Rat169 34592 D4Mgh20 36043 D4Rat49 intestine integrity trait (VT:0010554) post-insult time to onset of moribundity (CMO:0001896) increased cellular sensitivity to X-ray irradiation Experimental Radiation Injuries 69702;70067 11003700 4 144032425 219142061 2 - by one flank and peak markers 4 82861630 155893772 2 - by one flank and peak markers (LECxBN)xLEC 68066 634377 LEC BN/Sea 4 81959983 152055009 2 - by one flank and peak markers 4 82798864 152731274 2 - by one flank and peak markers 70178 rat Eaez Experimental allergic encephalomyelitis QTL z 18 2.4 33971 D18Mit7 60774 D18Wox1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) abnormal inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;61031 10640775 18 12385472 14882610 1 - by flanking markers 18 13239641 58239641 4 - by one flank marker only F2;resistant E3 rat x susceptible DA, LOD=2.4 (severity)=2.3 (duration af disease) E3xDA 60997 61013 DA E3 18 12597179 15099007 1 - by flanking markers 18 12357786 12874620 1 - by flanking markers 70179 rat Xhs2 X-ray hypersensitivity QTL 2 1 3.2 37198 D1Rat186 42448 D1Rat392 42449 D1Rat391 intestine integrity trait (VT:0010554) post-insult time to onset of moribundity (CMO:0001896) increased cellular sensitivity to X-ray irradiation Experimental Radiation Injuries 69702;70067 11003700 1 17574243 21618253 1 - by flanking markers 1 15833442 19577925 1 - by flanking markers (LECxBN)xLEC 68066 634377 LEC BN/Sea 1 16033078 20130904 1 - by flanking markers 1 15321100 19121980 1 - by flanking markers 70180 rat BpQTLcluster10 Blood pressure QTL cluster 10 11 3.19 33642 D11Mit1 33700 D11Mit5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70067;68932 10779487 11 39486246 84486246 4 - by one flank marker only 11 35910590 80910590 4 - by one flank marker only F2 SHRxBN 60985 61000 BN SHR 11 35900634 80900634 4 - by one flank marker only 11 34918041 79918041 4 - by one flank marker only 70181 rat BpQTLcluster11 Blood pressure QTL cluster 11 13 6.922 10462 D13Mgh13 34080 D13Mgh10 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932;1625678 10779487;17566075 13 41256240 104953660 1 - by flanking markers 13 52688796 97688796 4 - by one flank marker only F2 SSxBN 60985 69369 BN SS 13 36147533 99968921 1 - by flanking markers 13 31241331 93395974 1 - by flanking markers 70182 rat BpQTLcluster12 Blood pressure QTL cluster 12 15 3.53 34160 D15Mgh5 34222 D15Mgh8 2536 Ednrb arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) increased systemic arterial blood pressure hypertension 70067;68932 10779487 15 84794402 106602088 1 - by flanking markers 15 80362100 102741229 1 - by flanking markers F2 SSxBN 60985 69369 BN SS 15 81255430 103164962 1 - by flanking markers 15 73690657 95018120 1 - by flanking markers 70183 rat BpQTLcluster13 Blood pressure QTL cluster 13 16 3.654 33848 D16Mit2 34066 D16Mgh1 2708 Glud1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 16 4954192 45651269 1 - by flanking markers 16 4304396 46137590 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 16 5013802 45905331 1 - by flanking markers 16 4227609 43025077 1 - by flanking markers 70184 rat BpQTLcluster14 Blood pressure QTL cluster 14 17 3.38 33882 D17Mit2 33654 D17Mit7 2518 Drd1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 17 10820271 35195242 1 - by flanking markers 17 14575011 38353858 1 - by flanking markers F2 FHHxACI 10000 60993 ACI/N FHH 17 1 33303755 2 - by one flank and peak markers 17 1 31990913 2 - by one flank and peak markers 70185 rat BpQTLcluster15 Blood pressure QTL cluster 15 18 4.61 34290 D18Mgh4 34218 D18Mgh2 2060 Adrb2 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in systolic blood pressure (CMO:0000607);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 18 61092546 79012526 1 - by flanking markers 18 62313296 79585008 1 - by flanking markers F2 SSxBN 60985 69369 BN SS 18 61901354 79948616 1 - by flanking markers 18 59712417 76477814 1 - by flanking markers 70186 rat Niddm26 Non-insulin dependent diabetes mellitus QTL 26 9 3.87 44567 D9Wox19 34088 D9Mgh2 36582 D9Rat21 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611 10594234;12420133;23118743;19697080 Gluco54 (maps to same region) 9 24554173 92471992 1 - by flanking markers 9 18347567 84432994 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 9 25692342 92741406 1 - by flanking markers 9 22071169 86369743 1 - by flanking markers 70187 rat Pancm5 Pancreatic morphology QTL 5 14 16.7 35342 D14Rat8 2670 Gck pancreas mass (VT:0010144) pancreas weight to body weight ratio (CMO:0000630) impaired pancreas regeneration type 2 diabetes mellitus 70067;69697;2313613 9745032;19575795 14 32389647 86875295 1 - by flanking markers 14 32584630 86587723 1 - by flanking markers F2 OLETFxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 32593926 86191589 1 - by flanking markers 14 30320092 80829842 1 - by flanking markers 70188 rat BpQTLcluster1 Blood pressure QTL cluster 1 1 4.864 33891 D10Mit5 3710 Slc4a1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 10 21392295 90101181 1 - by flanking markers 10 21607719 91471072 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 10 21523906 90312401 1 - by flanking markers 10 42323132 87323132 4 - by one flank marker only 70189 rat Mcs5 Mammary carcinoma susceptibility QTL 5 5 10.51 34501 D5Mgh26 69569 D5Uwm38 35771 D5Rat22 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885;1601189 11139513;18057545;17404222 5 61525796 141515484 1 - by flanking markers 5 58063971 139156771 1 - by flanking markers 61105 737908 WKY/NHsd WF/NHsd 5 56991667 137729065 1 - by flanking markers 5 55805606 132207589 1 - by flanking markers 70190 rat Mcs6 Mammary carcinoma susceptibility QTL 6 7 2.29 34051 D7Mit28 35749 D7Rat45 34051 D7Mit28 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885;5133689 11139513;18057545;21625632 Mcs2 (sub_region) 7 33124095 71522360 1 - by flanking markers 7 29204226 68057251 1 - by flanking markers 61105 737908 WKY/NHsd WF/NHsd 7 33044449 71352127 1 - by flanking markers 7 26737401 63902784 1 - by flanking markers 70191 rat BpQTLcluster4 Blood pressure QTL cluster 4 3 3.0 34347 D3Mgh16 11260 D3Mit8 3632 Scn2a arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in systolic blood pressure (CMO:0000607) increased systemic arterial blood pressure hypertension 70067;68932 10779487 3 11361699 58322647 1 - by flanking markers 3 6373335 47588420 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 3 6000748 51687917 1 - by flanking markers 3 10778704 50302886 1 - by flanking markers 70192 rat BpQTLcluster5 Blood pressure QTL cluster 5 4 4.183 11383 D4Mit23 10144 D4Mgh16 3711 Slc4a2 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in pulse pressure (CMO:0001882);diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);percent change in mean arterial blood pressure (CMO:0002035);percent change in systolic blood pressure (CMO:0000747);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 4 61427664 177782856 1 - by flanking markers 4 61646915 116611046 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 4 61708341 113100992 1 - by flanking markers 4 62933508 114921294 1 - by flanking markers 70193 rat Mcs7 Mammary carcinoma susceptibility QTL 7 10 2.38 35627 D10Rat12 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885;61516 11139513;18057545;11015598 10 75258929 112200500 5 - by peak with adj size 10 76698917 110718848 5 - by peak with adj size 61105 737908 WKY/NHsd WF/NHsd 10 75544754 112626471 5 - by peak with adj size 10 72224939 107211142 5 - by peak with adj size 70194 rat BpQTLcluster6 Blood pressure QTL cluster 6 5 4.125 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533);absolute change in systolic blood pressure (CMO:0000607);percent change in mean arterial blood pressure (CMO:0002035);percent change in systolic blood pressure (CMO:0000747) increased systemic arterial blood pressure hypertension 70067;68932 10779487 F2 SHRxBN 60985 61000 BN SHR 70195 rat Mcs8 Mammary carcinoma susceptibility QTL 8 14 4.28 36536 D14Rat1 40104 D14Rat99 60763 D14Wox3 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 70067;62417;2291885 11139513;18057545 14 4830815 26295128 1 - by flanking markers 14 4895894 26416791 1 - by flanking markers 61105 737908 WKY/NHsd WF/NHsd 14 4833233 26466248 1 - by flanking markers 14 3813074 24531477 1 - by flanking markers 70196 rat BpQTLcluster7 Blood pressure QTL cluster 7 6 6.82 11241 D6Mit3 33624 D6Mit12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 6 2916542 85163175 1 - by flanking markers 6 3158498 75049527 1 - by flanking markers F2 GHxBN 60984 60985 GH BN 6 75623277 120623277 4 - by one flank marker only 6 72202632 117202632 4 - by one flank marker only 70197 rat BpQTLcluster8 Blood pressure QTL cluster 8 8 3.482 10177 D8Mit7 67379 Acaa1a arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607);mean arterial blood pressure (CMO:0000009);pulse pressure (CMO:0000292);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;68932 10779487 8 49155552 127243232 1 - by flanking markers 8 79313887 124313887 4 - by one flank marker only F2 SSxBN 60985 69369 BN SS 8 50529480 128036471 1 - by flanking markers 8 46531639 119088626 1 - by flanking markers 70198 rat BpQTLcluster9 Blood pressure QTL cluster 9 10 2.94 33891 D10Mit5 3710 Slc4a1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70067;68932 10779487 10 21392295 90101181 1 - by flanking markers 10 21607719 91471072 1 - by flanking markers F2 SHRxBN 60985 61000 BN SHR 10 21523906 90312401 1 - by flanking markers 10 42323132 87323132 4 - by one flank marker only 70199 rat Coreg1 Compensatory renal growth QTL 1 6 11.8 12.0 36787 D6Rat37 33977 D6Mit4 33828 D6Mit9 kidney mass (VT:0002707) compensatory renal growth score (CMO:0001894) increased compensatory renal growth 70067;69708 10732705 2003;2023 Asip;Acp3 co-recessive Aia1 (maps to same region);Cia1 (maps to same region);Oia1 (maps to same region);Pia1 (maps to same region) 6 51322427 70194178 1 - by flanking markers 6 36481546 59946874 1 - by flanking markers SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 6 38196412 60606431 1 - by flanking markers 6 35691618 57730540 1 - by flanking markers 70200 rat Alc18 Alcohol consumption QTL 18 4 9.2 11.0 34308 D4Mgh9 33656 D4Mit9 35409 D4Rat34 drinking behavior trait (VT:0001422) ethanol intake volume to total fluid intake volume ratio (CMO:0001591) alcohol preference alcohol use disorder 70067;69704;631849;1578304;2317896;8662401 9880658;12665621;16470346;20200994;24611993 3197;3729;70547 Npy;Snca;Crhr2 additive 4 55067674 214306934 1 - by flanking markers 4 54828166 152570244 1 - by flanking markers intercross PxNP 634380 634381 iP/Iusm iNP/Iusm 4 55324953 148360954 1 - by flanking markers 4 56647873 149491524 1 - by flanking markers 70201 rat Gcr1 Gastric cancer resistance QTL 1 4 2.7 41232 D4Rat182 35088 D4Rat59 10158 D4Arb16 stomach morphology trait (VT:0000470) stomach tumor susceptibility score (CMO:0002043) decreased incidence of induced tumors Stomach Neoplasms 70067;69698 10706129 4 184956749 209380347 1 - by flanking markers 4 121990539 150048167 1 - by flanking markers (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 4 119705414 146087100 1 - by flanking markers 4 120260281 147278687 1 - by flanking markers 70202 rat Alc19 Alcohol consumption QTL 19 3 2.5 33782 D3Mit10 37010 D3Rat49 drinking behavior trait (VT:0001422) ethanol intake volume to total fluid intake volume ratio (CMO:0001591) alcohol preference alcohol use disorder 70067;69704 9880658 69364 Scn1a 3 1 33340453 4 - by one flank marker only 3 1 23762628 4 - by one flank marker only intercross PxNP 634380 634381 iP/Iusm iNP/Iusm 3 1 28136884 4 - by one flank marker only 3 1 27494778 4 - by one flank marker only 70203 rat Gcr2 Gastric cancer resistance QTL 2 3 2.6 34186 D3Mgh9 37010 D3Rat49 35054 D3Rat55 stomach morphology trait (VT:0000470) stomach tumor susceptibility score (CMO:0002043) decreased incidence of induced tumors Stomach Neoplasms 70067;69698 10706129 3 8648011 33340453 1 - by flanking markers 3 4010230 23762628 1 - by flanking markers (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 3 3285929 28136884 1 - by flanking markers 3 8658162 27494778 1 - by flanking markers 70204 rat Niddm20 Non-insulin dependent diabetes mellitus QTL 20 14 5.1 8.0E-6 34981 D14Rat23 45195 D14Wox7 37030 D14Rat3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance;impaired glucose tolerance type 2 diabetes mellitus 70067;69691;69696;625760;1643009;7207431;10755343 9824537;10594234;12420133;17710484;23118743;26296322 1306722;1308102 Coq2;Plac8 14 2222207 19130933 2 - by one flank and peak markers 14 1764386 18915962 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 2227825 19230541 2 - by one flank and peak markers 14 1217606 16960180 2 - by one flank and peak markers 70205 rat Gcr3 Gastric cancer resistance QTL 3 16 2.3 11446 D16Mgh4 42018 D16Arb3 37054 D16Rat17 stomach morphology trait (VT:0000470) stomach tumor depth of invasion (CMO:0001888);stomach tumor diameter (CMO:0001889) decreased incidence of induced tumors Stomach Neoplasms 70067;69698 10706129 16 19256518 70254563 1 - by flanking markers 16 18121291 70196694 1 - by flanking markers F2 (ACIxBUF)xACI 10000 60986 ACI/N BUF/N 16 19398187 70590230 1 - by flanking markers 16 17696791 82635055 2 - by one flank and peak markers 70206 rat Alc20 Alcohol consumption QTL 20 8 2.0 33559 D8Mit5 36117 D8Rat46 drinking behavior trait (VT:0001422) ethanol intake volume to total fluid intake volume ratio (CMO:0001591) alcohol preference alcohol use disorder 70067;69704 9880658 2520;2846 Drd2;Htr1b 8 33603024 61319565 1 - by flanking markers 8 32203394 43314410 1 - by flanking markers intercross PxNP 634380 634381 iP/Iusm iNP/Iusm 8 33558660 44219353 1 - by flanking markers 8 30848154 40713225 1 - by flanking markers 70207 rat Niddm31 Non-insulin dependent diabetes mellitus QTL 31 7 3.9 35237 D7Rat35 34880 D7Rat31 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 70067;69696 10594234 7 24326613 32338830 1 - by flanking markers 7 20307479 28488710 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 7 24175337 32258115 1 - by flanking markers 7 18169505 26029351 1 - by flanking markers 70208 rat Niddm22 Non-insulin dependent diabetes mellitus QTL 22 11 3.61 10375 D11Mgh1 34112 D11Mgh4 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance;impaired glucose tolerance type 2 diabetes mellitus 70067;69691;69696;625760;7207431;10755342 9824537;10594234;12420133;23118743;25821834 1305614 Igf2bp2 11 65784538 89808355 1 - by flanking markers 11 61504483 84560092 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 11 62653365 86714483 1 - by flanking markers 11 59802794 82566553 1 - by flanking markers 70209 rat Niddm23 Non-insulin dependent diabetes mellitus QTL 23 1 2.82 11439 D1Mit30 43377 D1Wox9 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611 10594234;12420133;23118743;19697080 Gluco41 (maps to same region) 1 101048742 223187249 1 - by flanking markers 1 94473940 203416143 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 1 99983293 216325819 1 - by flanking markers 1 94494440 198324465 1 - by flanking markers 70210 rat Cm15 Cardiac mass QTL 15 17 6.5 22.0 45485 D17Wox9 35883 D17Rat44 36315 D17Rat41 heart right ventricle mass (VT:0007033) heart right ventricle wet weight (CMO:0000072) heart right ventricle hypertrophy;pulmonary hyperplasia;vascular smooth muscle hypertrophy Hyperplasia;Pulmonary Hypertension, Hypoxia-Induced ;Right Ventricular Hypertrophy;pulmonary hypertension 70067;69699;10401832 11157698;26258299 2343;620314;1309305 Chrm3;Ryr2;Slc39a12 dominant 17 63969458 75653670 1 - by flanking markers 17 65900398 81612488 1 - by flanking markers F2 F344xWKY 61097 61109 WKY/NCruk F344/NHsd 17 62195703 73981731 1 - by flanking markers 10401835 WKY.F344-(D17Got91-D17Rat51)/Tja 17 57246723 70156904 1 - by flanking markers 70211 rat Niddm24 Non-insulin dependent diabetes mellitus QTL 24 1 3.79 10674 D1Mgh12 35457 D1Rat90 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;11532750;2312611;1358859 10594234;12420133;23118743;27523322;19697080;15883013 620040;1559884 Prdx3;Plekhs1 Bw54 (maps to same region);Gluco51 (maps to same region) 1 270716905 289137268 1 - by flanking markers 1 247322146 267111153 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 1 236795785 281795785 4 - by one flank marker only 1302647 F344.OLETF-(D5Rat166-D5Rat90)/Tj 1 214647894 259647894 4 - by one flank marker only 70212 rat Niddm25 Non-insulin dependent diabetes mellitus QTL 25 5 3.54 34377 D5Mgh4 33680 D5Mit13 34047 D5Mit1 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611 10594234;12420133;23118743;19697080 Gluco42 (maps to same region) 5 1 140429983 2 - by one flank and peak markers 5 1 138272129 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 5 1 136640934 2 - by one flank and peak markers 5 1 131345958 2 - by one flank and peak markers 70213 rat Niddm27 Non-insulin dependent diabetes mellitus QTL 27 12 3.72 34417 D12Mgh2 33963 D12Mit4 34729 D12Mgh5 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431;2312611;7401255 10594234;12420133;23118743;19697080;23596094 Bw128 (maps to same region);Gluco44 (maps to same region) 12 24883568 45634190 1 - by flanking markers 12 18937438 39323046 2 - by one flank and peak markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 12 22876297 43799153 1 - by flanking markers 12 19835789 38193007 1 - by flanking markers 70214 rat Niddm28 Non-insulin dependent diabetes mellitus QTL 28 14 4.06 60765 D14Wox5 35837 D14Rat27 2289 Cckar blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431 10594234;12420133;23118743 14 41435114 81531552 1 - by flanking markers 14 42599990 81222938 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 41637569 80841518 1 - by flanking markers 14 39998251 75582726 1 - by flanking markers 70215 rat Niddm29 Non-insulin dependent diabetes mellitus QTL 29 16 3.54 35527 D16Rat7 36988 D16Rat15 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 70067;69696;625760;7207431 10594234;12420133;23118743 16 20607927 79886465 1 - by flanking markers 16 19510772 80047126 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 16 20755556 80316424 1 - by flanking markers 16 19004435 75226532 1 - by flanking markers 70216 rat Cm14 Cardiac mass QTL 14 3 2.1 60801 D3Wox3 2534 Edn3 66594 D3Mco5 heart mass (VT:0007028) heart wet weight (CMO:0000069) enlarged heart;increased systemic arterial blood pressure hypertension 70067;69705;68910;7401270 9922389;10642295;23648703 3 36017179 178925563 1 - by flanking markers 3 27506718 166514051 1 - by flanking markers (SxR)xS 10040 10041 SR/Jr SS/Jr 3 30846101 172879276 1 - by flanking markers 3 31172320 163586636 1 - by flanking markers 70218 rat Cm28 Cardiac mass QTL 28 9 8.3 1.0E-4 31.9 37416 D9Rat70 61287 D9Uia6 35819 D9Rat26 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased systemic arterial blood pressure hypertension 70067;61516;2302803 11015598;18854752 additive Bp333 (maps to same region) 9 27914255 83452061 1 - by flanking markers 9 21667066 77171049 1 - by flanking markers F2;intercross SxSHR;SS/JrxSHR 10041 724574 SS/Jr SHR/NHsd 9 29075079 83686404 1 - by flanking markers 9 25268044 79271759 1 - by flanking markers 70220 rat Bp55 Blood pressure QTL 55 13 5.75 33733 D13Mit2 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 70067;61043 8952608 13 47487222 92487222 5 - by peak with adj size 13 39572400 84572400 5 - by peak with adj size F2 SHRxWKY 61000 61103 SHR WKY 13 42508345 87508345 5 - by peak with adj size 13 37374509 82374509 5 - by peak with adj size 70221 rat Bp56 Blood pressure QTL 56 X 4.9 6.1 34192 DXMgh9 33717 DXMit4 34924 DXRat15 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69713 9931114 X 61984911 71224072 1 - by flanking markers X 79626109 88514168 1 - by flanking markers F2 SBHxSBN 631572 631573 SBH/Ygl SBN/Ygl X 61398097 70352120 1 - by flanking markers X 57042141 65612192 1 - by flanking markers 70222 rat Eae2 Experimental allergic encephalomyelitis QTL 2 4 4.3 34200 D4Mgh1 34716 D4Mgh14 34200 D4Mgh1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69694 9973459 4 18184531 37534268 1 - by flanking markers 4 17617956 36592773 1 - by flanking markers F2 LEWxBN 60985 60999 BN LEW 4 18222187 37685319 1 - by flanking markers 4 21333343 39505420 1 - by flanking markers 70223 rat Bp57 Blood pressure QTL 57 10 5.0 33891 D10Mit5 35503 D10Rat20 35731 D10Rat33 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 10 21392295 83353613 1 - by flanking markers 10 21607719 84443989 1 - by flanking markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 10 21523906 83549467 1 - by flanking markers 10 1 80676123 2 - by one flank and peak markers 70224 rat Eae3 Experimental allergic encephalomyelitis QTL 3 10 4.1 33632 D10Mit10 34445 D10Mgh6 34318 D10Mgh10 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;Paresis;multiple sclerosis 70067;69694;2293859;2296064 9973459;16624898;18453595 Eae23 (sub_region);Eau7 (maps to same region) 10 27082535 63366218 1 - by flanking markers 10 27184741 67678060 1 - by flanking markers F2 LEWxBN 60985 60999 BN LEW 10 27237530 64648311 1 - by flanking markers 10 26521957 61345413 1 - by flanking markers 70225 rat Bp58 Blood pressure QTL 58 1 3.3 36596 D1Rat53 36640 D1Rat14 38028 D1Rat121 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70067;69692 11082136 1 36395668 180434202 1 - by flanking markers 1 1 166496140 2 - by one flank and peak markers F2 MHSxMNS 10025 10028 MHS/Gib MNS/Gib 1 34993530 173445086 1 - by flanking markers 1 32356093 162846471 1 - by flanking markers 70226 rat Eae4 Experimental allergic encephalomyelitis QTL 4 9 36984 D9Rat29 33842 D9Mit6 34264 D9Mgh5 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) increased inflammatory response;paresis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 70067;69712;7241236 10072499;20368159 3951 Vav1 Iresp3 (maps to same region) 9 28304251 46197383 2 - by one flank and peak markers 9 1526958 22066101 1 - by flanking markers F2 DAxBN 60985 60997 BN DA 9 1 29467098 2 - by one flank and peak markers 9 1 25661317 2 - by one flank and peak markers 70363 rat Bp71 Blood pressure QTL 71 10 0.04 34445 D10Mgh6 38516 D10Rat106 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 69734 11471055 3185 Nos2 10 63366082 84394530 1 - by flanking markers 10 67677924 85489479 1 - by flanking markers 631220 SS.LEW-(D10Mco1-D10Mco31)/Ayd 10 64648175 84601269 1 - by flanking markers 10 61345276 81714865 1 - by flanking markers 70364 rat Bp72 Blood pressure QTL 72 10 40794 D10Rat141 35256 D10Rat11 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 69734 11471055 2493 Ace 10 54184250 99184250 4 - by one flank marker only 10 55633982 100633982 4 - by one flank marker only 728137 SS.LEW-(D10Rat141-D10Mgh1)/Ayd 10 91548145 99492409 1 - by flanking markers 10 51121100 96121100 4 - by one flank marker only 71111 rat Iddm8 Insulin dependent diabetes mellitus QTL 8 6 1.9 0.002 10507 D6Mgh2 2880 Ighe 10507 D6Mgh2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) Experimental Diabetes Mellitus 61077;61480;619674;619685;2303106 9571179;9892222;9858659;11327715;19168599 Iddm29 (maps to same region) 6 141822172 147061209 1 - by flanking markers 6 110581307 147636619 5 - by peak with adj size F1;backcross BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 6 132652096 138068606 1 - by flanking markers 6 105156861 140994061 5 - by peak with adj size 71112 rat Bw115 Body weight QTL 115 1 6.0 1.0E-4 35457 D1Rat90 33903 D1Mit7 33694 D1Mit8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight;increased body weight;increased circulating glucose level type 2 diabetes mellitus 61072;619678;2312611;619669;1358859 9585427;10373320;19697080;11071303;15883013 additive Bw116 (maps to same region);Bw54 (maps to same region);Bw85 (maps to same region);Scl67 (interacts with);Stl31 (maps to same region) 1 262617374 289137107 1 - by flanking markers 1 240980321 267110921 1 - by flanking markers F2;intercross OLETFxBN 60985 61014 BN OLETF 1 281795624 282763074 4 - by one flank marker only 1 259647732 260522016 4 - by one flank marker only 71113 rat Cari2 Carrageenan-induced inflammation QTL 2 2 2.7 0.009 33983 D2Mit23 34461 D2Mgh12 10582 D2Mit12 hypodermis integrity trait (VT:0010550) inflammatory exudate volume (CMO:0001429) abnormal inflammatory response Inflammation;hyperglycemia 70860;69693;61072;69694 11306811;10087293;9585427;9973459 recessive 2 166931667 235592880 1 - by flanking markers 2 146659370 210636169 1 - by flanking markers F2;intercross F344xLEW 60999 70509 LEW F344/NRrrc 2 147522550 217498710 1 - by flanking markers 2 141596551 202447032 1 - by flanking markers 71114 rat Niddm14 Non-insulin dependent diabetes mellitus QTL 14 7 4.5 10431 D7Wox18 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased body weight;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 61072;2296064 9585427;18453595 Eau6 (maps to same region) 7 93629275 138629275 5 - by peak with adj size 7 90478161 135478161 5 - by peak with adj size F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 7 93726906 138726906 5 - by peak with adj size 7 84257275 129257275 5 - by peak with adj size 71115 rat Niddm15 Non-insulin dependent diabetes mellitus QTL 15 14 4.8 34981 D14Rat23 33953 D14Mit1 33579 D14Mit5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance;increased body weight;increased circulating glucose level type 2 diabetes mellitus 61072 9585427 14 2222207 12623486 1 - by flanking markers 14 1764386 12386683 1 - by flanking markers F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 14 2227825 12680613 1 - by flanking markers 14 1217606 11030812 1 - by flanking markers 71116 rat Niddm16 Non-insulin dependent diabetes mellitus QTL 16 X 7.81 34405 DXMgh2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 2 diabetes mellitus 70858;619678 7607056;10373320 3225 Odb1 X 18462583 63462583 5 - by peak with adj size X 36612231 81612231 5 - by peak with adj size F2;backcross OLETFxBN 60985 61014 BN OLETF X 18153352 63153352 5 - by peak with adj size X 15297802 60297802 5 - by peak with adj size 71117 rat Niddm17 Non-insulin dependent diabetes mellitus QTL 17 14 2.35 11030 D14Mit4 10113 D14Mit2 11030 D14Mit4 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance 70861 8702404 3226 Odb2 14 21276795 66276795 5 - by peak with adj size 14 22520291 67520291 5 - by peak with adj size F2 OLETFxBN 61014 634367 OLETF BN/CrlCrlj 14 19161893 43957503 1 - by flanking markers 14 17593761 42336881 1 - by flanking markers 71118 rat Thym1 Thymus enlargement QTL 1 1 10.17 0.001 33571 D1Mit6 10952 D1Wox21 11201 D1Mgh11 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) thymus hyperplasia Thymus Hyperplasia 70859;634747;631171 10792781;8672128;9716658 Thym3 (interacts with);Thym4 (sub_region) 1 160649707 205649707 4 - by one flank marker only 1 141471946 186471946 4 - by one flank marker only F1;backcross WKY/NCrjxBUF/Mna 61118 61119 BUF/Mna WKY/NCrlCrlj 1 153655976 198655976 4 - by one flank marker only 1 136829932 181829932 4 - by one flank marker only 71119 rat Thym2 Thymus enlargement QTL 2 13 3.8 10205 D13Mgh17 3804 Syt2 41967 D13Arb10 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) thymus hyperplasia Thymus Hyperplasia 70859;634747;631171 10792781;8672128;9716658 13 56630530 95196860 1 - by flanking markers 13 47699094 88282502 1 - by flanking markers F1;backcross WKY/NCrjxBUF/Mna 61118 61119 BUF/Mna WKY/NCrlCrlj 13 51577824 90675199 1 - by flanking markers 13 46197976 84753113 1 - by flanking markers 71120 rat Niddm21 Non-insulin dependent diabetes mellitus QTL 21 8 3.73 10435 D8Mgh7 36039 D8Rat58 34723 D8Mgh9 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 61021;625760;2300331;7207431;2298688 10051320;12420133;18421176;23118743;18612083 Gluco36 (maps to same region) 8 1 3460265 4 - by one flank marker only 8 3039822 61462321 1 - by flanking markers F2 OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 8 1 3442354 4 - by one flank marker only 8 1 3402289 4 - by one flank marker only 619613 rat Bp77 Blood pressure QTL 77 1 0.01 10165 D1Wox34 36566 D1Rat55 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70855;1625015 11509479;17332427 62086 Acsm3 1 182435050 184481458 1 - by flanking markers 1 168382195 170489972 1 - by flanking markers F2;intercross SHRxWKY;WKY.SHR-SaxSHR.WKY-Sa 631589 SHR.WKY-(D1Wox34-D1Rat164)/Njs 1 175447029 220447029 4 - by one flank marker only 1 164747424 209747424 4 - by one flank marker only 619614 rat Bp78 Blood pressure QTL 78 1 0.001 36454 D1Rat56 36239 D1Rat111 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70855;1625015 11509479;17332427 62086 Acsm3 1 191393321 222009153 1 - by flanking markers 1 172926151 202350882 1 - by flanking markers F2;intercross SHRxWKY;WKY.SHR-SaxSHR.WKY-Sa 631591 631592 WKY.SHR-(D1Rat56-D1M7Mit206)/Njs WKY.SHR-(D1Rat236-D1M7Mit206)/Njs 1 184419946 215097919 1 - by flanking markers 1 169112897 197261052 1 - by flanking markers 619615 rat Bp80 Blood pressure QTL 80 13 0.0354 34029 D3Mit1 2168 Atp1a2 11231 D13Wox5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70857 9299556 3554 Ren dominant 13 15923248 95198290 2 - by one flank and peak markers 13 4256134 88283918 2 - by one flank and peak markers F2;backcross SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 13 45676629 90676629 4 - by one flank marker only 13 39754544 84754544 4 - by one flank marker only 619616 rat Bp79 Blood pressure QTL 79 4 0.0292 2901 Il6 11015 D4Mit24 60732 D4Mit6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70857;61035 9299556;9780220 3197 Npy dominant 4 3095536 144249450 1 - by flanking markers 4 456799 78039637 1 - by flanking markers F2;backcross SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 4 3043231 79575658 1 - by flanking markers 4 5214602 78882945 1 - by flanking markers 619617 rat Bp283 Blood pressure QTL 283 17 2.61 0.002 35505 D17Rat54 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70856 11053483 F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 619618 rat Rf3 Renal disease susceptibility QTL 3 3 6.5 0.001 33808 D3Mit4 urine albumin amount (VT:0002871) urine albumin excretion rate to body weight ratio (CMO:0001270) glomerulosclerosis;increased urine protein level end stage renal disease 70856 11053483 3 120821325 165821325 5 - by peak with adj size 3 108688653 153688653 5 - by peak with adj size F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 3 114376250 159376250 5 - by peak with adj size 3 107693393 152693393 5 - by peak with adj size 619619 rat Rf4 Renal disease susceptibility QTL 4 14 4.1 0.002 34479 D14Mgh7 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) glomerulosclerosis end stage renal disease 70856;1582571 11053483;16837819 14 1 34346301 5 - by peak with adj size 14 1 34067237 5 - by peak with adj size F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 14 1 34403399 5 - by peak with adj size 14 1 32754612 5 - by peak with adj size 619620 rat Rf5 Renal disease susceptibility QTL 5 17 2.99 0.001 36331 D17Mit12 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) glomerulosclerosis;increased urine protein level end stage renal disease 70856;1582571 11053483;16837819 F2 FHH/EurxACI 10000 10015 ACI/N FHH/Eur 631198 rat Cm22 Cardiac mass QTL 22 2 4.3 8.0E-4 22.4 33620 D2Mit6 34204 D2Mgh7 34114 D2Mgh15 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy 61484 9495256 recessive Cm23 (interacts with);Cm25 (interacts with) 2 98037122 177517146 1 - by flanking markers 2 77630629 156142910 1 - by flanking markers intercross SHRxDRY 60995 728194 DRY SHR/N 2 78321410 158159410 1 - by flanking markers 2 76539322 150540526 1 - by flanking markers 631199 rat Cm23 Cardiac mass QTL 23 1 4.6 4.0E-4 24.5 34399 D1Mgh9 34011 D1Mit2 33959 D1Mit3 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy Left Ventricular Hypertrophy 61484 9495256 recessive Cm22 (interacts with);Cm25 (interacts with) 1 130149502 195235510 2 - by one flank and peak markers 1 134980682 176854992 1 - by flanking markers intercross SHRxDRY 60995 728194 DRY SHR/N 1 124603592 188289386 2 - by one flank and peak markers 1 115585465 172949803 2 - by one flank and peak markers 631200 rat Cm25 Cardiac mass QTL 25 3 4.8 1.0E-4 16.5 35380 D3Rat27 34979 D3Rat38 34918 D3Rat29 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy Left Ventricular Hypertrophy 69706;61484 10205229;9495256 3439 Ptgs1 dominant Cm22 (interacts with);Cm23 (interacts with) 3 69593925 99297509 1 - by flanking markers 3 58882977 87981062 1 - by flanking markers intercross WKYxF344 61097 61109 WKY/NCruk F344/NHsd 3 63049050 92654302 1 - by flanking markers 3 61134348 89115068 1 - by flanking markers 631201 rat Panci1 Pancreas inflammation QTL 1 7 0.0 0.001 12.0 35304 D7Rat4 38306 D7Rat97 pancreas integrity trait (VT:0010560) percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214) increased body weight;pancreas inflammation pancreatitis 619682 11414764 additive 7 126177060 136963167 1 - by flanking markers 7 123574930 134614033 1 - by flanking markers intercross BNxWBN/Kob;BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc 7 126463827 137325116 1 - by flanking markers 7 116677189 127103496 1 - by flanking markers 631202 rat Gluco13 Glucose level QTL 13 1 1.0E-4 0.1 36023 D1Rat38 619844 Cnga4 33959 D1Mit3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance;increased body weight type 2 diabetes mellitus 631173 12705906 1 140507063 177253787 1 - by flanking markers 1 133566530 163141556 1 - by flanking markers backcross SDTxBN 631219 1549801 SDT/Jcl BN/Seac 1 139523928 170246858 1 - by flanking markers 1 131763437 159756369 1 - by flanking markers 631203 rat Gluco14 Glucose level QTL 14 2 1.0E-4 0.1 38466 D2Rat118 38942 D2Rat156 2591 Fabp2 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 631173 12705906 2591 Fabp2 2 239931503 254122318 1 - by flanking markers 2 214988814 227924156 1 - by flanking markers backcross SDTxBN 631219 1549801 SDT/Jcl BN/Seac 2 221880206 235570970 1 - by flanking markers 2 206665645 219003804 1 - by flanking markers 631204 rat Gluco15 Glucose level QTL 15 X 0.001 0.08 11236 DXWox11 39154 DXRat83 11494 DXWox20 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance type 2 diabetes mellitus 631173 12705906 X 2631211 24746304 1 - by flanking markers X 13041853 43167410 1 - by flanking markers backcross SDTxBN 631219 1549801 SDT/Jcl BN/Seac X 1838166 24331837 1 - by flanking markers X 1623715 22646544 1 - by flanking markers 631205 rat Bp196 Blood pressure QTL 196 1 4.0 1.0E-4 34.4 34244 D1Mgh10 34134 D1Mgh1 33959 D1Mit3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 61484 9495256 additive 1 127336420 223910550 1 - by flanking markers 1 119780561 204280278 1 - by flanking markers intercross SHRxDRY 60995 728194 DRY SHR/N 1 126240667 217054291 1 - by flanking markers 1 118944897 199050459 1 - by flanking markers 631206 rat Niddm40 Non-insulin dependent diabetes mellitus QTL 40 1 33806 D1Mit24 60788 D1Wox7 33770 D1Mit12 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 619671 10902185 1 145651184 181328888 1 - by flanking markers 1 139026999 167337781 1 - by flanking markers intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 1 144723107 174343537 1 - by flanking markers 1 136745990 163747690 1 - by flanking markers 631207 rat Niddm41 Non-insulin dependent diabetes mellitus QTL 41 17 34276 D17Mgh2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) impaired glucose tolerance type 2 diabetes mellitus 619671 10902185 17 1 40301379 5 - by peak with adj size 17 1 43786390 5 - by peak with adj size intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 17 1 38243814 5 - by peak with adj size 17 1 37830672 5 - by peak with adj size 631208 rat Bw1 Body weight QTL1 2 5.09 13.8 60793 D2Wox3 34190 D2Mgh19 mesenteric fat pad mass (VT:0010427) mesenteric fat pad weight to body weight ratio (CMO:0000654) abnormal abdominal fat pad morphology obesity 619690 11087657 semidominant 2 62195476 105314072 1 - by flanking markers 2 42882523 84991985 1 - by flanking markers F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 2 43149788 85642672 1 - by flanking markers 2 43171017 83575226 1 - by flanking markers 631209 rat Bw2 Body weight QTL2 4 4.2 11.3 36476 D4Rat3 35625 D4Rat14 34200 D4Mgh1 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690 11087657 recessive 4 6487066 44024417 1 - by flanking markers 4 5351609 41729771 1 - by flanking markers F2 OLETFxF344 61014 70509 OLETF F344/NRrrc 4 6467693 43414792 1 - by flanking markers 4 9940885 44463908 1 - by flanking markers 631210 rat Bw3 Body weight QTL3 8 5.9 34152 D8Mgh17 35717 D8Rat9 34310 D8Mgh4 mesenteric fat pad mass (VT:0010427) mesenteric fat pad weight to body weight ratio (CMO:0000654) abnormal abdominal fat pad morphology obesity 619690 11087657 additive 8 76889142 120414001 1 - by flanking markers 8 73102005 117434131 1 - by flanking markers OLETFxF344 61014 70509 OLETF F344/NRrrc 8 74917593 121080545 1 - by flanking markers 8 69349194 112783834 1 - by flanking markers 631211 rat Bw4 Body weight QTL4 9 5.31 16.5 35695 D9Rat44 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690 11087657 recessive 9 2813697 47813697 4 - by one flank marker only 9 2948882 47948882 4 - by one flank marker only OLETFxF344 61014 70509 OLETF F344/NRrrc 9 2880977 47880977 4 - by one flank marker only 9 5109826 50109826 4 - by one flank marker only 631212 rat Bw5 Body weight QTL5 14 5.43 12.4 35342 D14Rat8 33953 D14Mit1 60763 D14Wox3 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690;2298688 11087657;18612083 recessive Gluco38 (maps to same region) 14 12623486 32389647 1 - by flanking markers 14 12386683 32584630 1 - by flanking markers intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 14 12680613 32593926 1 - by flanking markers 14 11030812 30320092 1 - by flanking markers 631213 rat Bw60 Body weight QTL60 14 4.51 13.8 36512 D14Rat18 35897 D14Rat22 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) abnormal retroperitoneal fat pad morphology obesity 619690 11087657 recessive 14 85985284 106705037 1 - by flanking markers 14 85715836 102509397 1 - by flanking markers intercross OLETFxF344 61014 70509 OLETF F344/NRrrc 14 85307663 106641756 1 - by flanking markers 14 79950921 95876975 1 - by flanking markers 631214 rat Bw61 Body weight QTL61 1 3.4 1.0E-4 5.0 33903 D1Mit7 37754 D1Rat123 intramuscular adipose amount (VT:0010044) intramuscular fat area (CMO:0001162) abnormal adipose tissue distribution obesity 619672 11853145 recessive 1 245519018 262617194 1 - by flanking markers 1 223729371 240980142 1 - by flanking markers intercross F344xOLETF 61014 70509 OLETF F344/NRrrc 1 193220385 238220385 4 - by one flank marker only 1 173108781 218108781 4 - by one flank marker only 631215 rat Stl8 Serum triglyceride level QTL 8 1 9.27 1.0E-4 13.6 34009 D1Mit34 35457 D1Rat90 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 70852 10644432 1 252776360 290094216 2 - by one flank and peak markers 1 230963695 267910886 2 - by one flank and peak markers backcross BNxOLETF 60985 61014 BN OLETF 1 245529606 282763074 2 - by one flank and peak markers 1 225126575 260522016 2 - by one flank and peak markers 631216 rat Stl9 Serum triglyceride level QTL 9 8 4.71 1.0E-4 7.1 35987 D8Rat30 33858 D8Mit4 33973 D8Mit2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 70852 10644432 8 44187677 80296781 1 - by flanking markers 8 44484347 74178405 1 - by flanking markers backcross BNxOLETF 60985 61014 BN OLETF 8 45712475 75971259 1 - by flanking markers 8 41867010 70386132 1 - by flanking markers 631217 rat Activ1 Activity QTL 1 8 15.9 35.0 33919 D8Mit15 10169 D8Wox11 34068 D8Mgh11 voluntary movement trait (VT:0003491) number of photobeam interruptions in an experimental apparatus (CMO:0001517) hyperactivity;increased exploration in new environment Hyperkinesis 631170;631228;1358767 8944030;12660808;15685431 Activ2 (maps to same region);Stresp11 (maps to same region) 8 109621234 116312980 2 - by one flank and peak markers 8 106733287 113364148 1 - by flanking markers intercross WKYxWKHA 61103 68186 WKY WKHA/N 8 110212979 116947981 2 - by one flank and peak markers 8 102370617 108923645 2 - by one flank and peak markers 631260 rat Tcas2 Tongue tumor susceptibility QTL 2 1 4.93 34326 D1Mgh21 34244 D1Mgh10 33753 D1Mit5 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 631169;634723 12448007;11429048 1 216945382 223910677 1 - by flanking markers 1 197423292 204280406 1 - by flanking markers intercross DAxWF 60997 61007 DA WF 1 210019247 217054418 1 - by flanking markers 1 192485903 199050587 1 - by flanking markers 631261 rat Tcas3 Tongue tumor susceptibility QTL 3 4 6.88 33905 D4Mit11 3186 Nos3 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 631169;634723 12448007;11429048 4 7353767 157291086 1 - by flanking markers 4 6179441 91330582 1 - by flanking markers intercross WFxDA 60997 61007 DA WF 4 7342404 92484039 1 - by flanking markers 4 10814170 91360527 1 - by flanking markers 631262 rat Tcas4 Tongue tumor susceptibility QTL 4 14 7.29 60762 D14Wox10 11030 D14Mit4 60764 D14Wox4 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 631169;634723 12448007;11429048 14 19098311 43777078 1 - by flanking markers 14 19141961 45020354 1 - by flanking markers intercross DAxWF 60997 61007 DA WF 14 19191541 43957628 1 - by flanking markers 14 17622561 42337007 1 - by flanking markers 631263 rat Cm24 Cardiac mass QTL 24 5 3.5 18.6 40376 D5Rat173 11001 D5Wox10 39168 D5Rat99 heart mass (VT:0007028) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy 619659;731210 11157676;14678232 3193 Nppa codominant Bp155 (maps to same region);Lanf1 (maps to same region) 5 153656532 168465304 2 - by one flank and peak markers 5 150310201 165073513 2 - by one flank and peak markers intercross WKY/CfdxWKHA/Cfd 1579699 WKY.WKHA-(D5Rat45-D5Rat245)/Cfd 5 149832180 164807402 2 - by one flank and peak markers 5 143799107 158428037 2 - by one flank and peak markers 631264 rat Scl22 Serum cholesterol level QTL 22 18 6.2 3916 Ttr 2741 Nr3c1 3916 Ttr blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 61055 9199194 18 15307563 32348480 1 - by flanking markers 18 12406571 32459145 1 - by flanking markers intercross BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 18 15532963 32704022 1 - by flanking markers 18 11941791 31393320 1 - by flanking markers 631265 rat Iresp1 Immunoglobin response QTL1 20 8.3 17.0 34260 D20Mgh5 45676 D20Got13 37872 D20Rat31 blood anti-double stranded DNA antibody amount (VT:0004762) serum anti-DNA antibody level (CMO:0001533) increased susceptibility to type II hypersensitivity reaction allergic disease 619646 10898507 additive 20 11836888 16594863 1 - by flanking markers 20 9301974 13963223 1 - by flanking markers intercross LEW/RjxBN/Rj 631593 631594 LEW/Rj BN/Rj 20 9655642 14411641 1 - by flanking markers 20 9039719 13461775 1 - by flanking markers 631266 rat Bp132 Blood pressure QTL 132 2 5.0E-4 2633 Fst 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension 68910;619621;2301356;7401270 10642295;10406815;18819818;23648703 2071;2167;2263;1306589 Agtr1b;Atp1a1;Camk2d;Gca Bp13 (maps to same region);Bp14 (maps to same region);Bp163 (interacts with) 2 65576721 235592880 1 - by flanking markers 2 46542246 210636169 1 - by flanking markers congenic SS/JrxSR/Jr 631278 SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc 2 46537589 217498710 1 - by flanking markers 2 46123260 202447032 1 - by flanking markers 631267 rat Cia20 Collagen induced arthritis QTL 20 10 3.2 61274 D10Arb20 61275 D10Arb22 44839 D10Wox7 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 recessive Cia21 (interacts with,maps to same region);Cia22 (interacts with);Cia23 (interacts with);Cia5 (maps to same region,interacts with) 10 24340447 107484761 1 - by flanking markers 10 24006429 110718848 2 - by one flank and peak markers intercross 61109 631182 F344/NHsd DA/BklArbN 10 24483076 107857673 1 - by flanking markers 10 23444813 104060283 1 - by flanking markers 631268 rat Cia21 Collagen induced arthritis QTL 21 10 3.1 33585 D10Mit6 61275 D10Arb22 36749 D10Rat19 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 Cia20 (interacts with,maps to same region);Cia22 (interacts with);Cia23 (interacts with);Cia5 (maps to same region,interacts with) 10 14644150 107484761 1 - by flanking markers 10 14721135 110718848 2 - by one flank and peak markers 61109 631182 F344/NHsd DA/BklArbN 10 14827894 107857673 1 - by flanking markers 10 14487011 104060283 1 - by flanking markers 631269 rat Cia22 Collagen induced arthritis QTL 22 10 8.9 34053 D10Mit3 61275 D10Arb22 34485 D10Mgh4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 Cia20 (interacts with);Cia21 (interacts with);Cia23 (maps to same region);Cia5 (maps to same region,interacts with) 10 41091453 107484761 1 - by flanking markers 10 41339689 110718848 2 - by one flank and peak markers 10008 631182 BN/SsNHsd DA/BklArbN 10 41260363 107857673 1 - by flanking markers 10 40035094 104060283 1 - by flanking markers 631270 rat Cia23 Collagen induced arthritis QTL 23 10 3.9 34053 D10Mit3 61275 D10Arb22 34485 D10Mgh4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631168 11003387 Cia20 (interacts with);Cia21 (interacts with);Cia22 (maps to same region);Cia5 (maps to same region,interacts with) 10 41091453 107484761 1 - by flanking markers 10 41339689 110718848 2 - by one flank and peak markers 10008 631182 BN/SsNHsd DA/BklArbN 10 41260363 107857673 1 - by flanking markers 10 40035094 104060283 1 - by flanking markers 631271 rat Lecl1 Lens clarity QTL 1 8 0.001 37712 D8Rat68 42225 D8Arb13 lens clarity trait (VT:0001304) age of onset/diagnosis of cataract (CMO:0001584) cornea opacity Corneal Opacity;cataract 68701 11252169 recessive 8 21522570 90659889 1 - by flanking markers 8 19460544 88679394 1 - by flanking markers intercross IExWKY/Izm 631285 631286 IER/Ihr WKY/Izm 8 21464919 91140553 1 - by flanking markers 8 18984168 84531599 1 - by flanking markers 631272 rat Lanf1 Left ventricular atrial natriuretic factor QTL 1 5 12.0 44.3 39168 D5Rat99 42770 D5Rat245 41070 D5Rat180 heart left ventricle natriuretic peptide A amount (VT:0010596) heart left ventricle natriuretic peptide A level (CMO:0002165) increased circulating atrial natriuretic factor Left Ventricular Hypertrophy 619659;731210 11157676;14678232 3193 Nppa codominant Bp155 (maps to same region);Cm24 (maps to same region) 5 161060798 177180328 2 - by one flank and peak markers 5 157691737 173096209 2 - by one flank and peak markers intercross WKY/CfdxWKHA/Cfd 631275 631276 WKY/Cfd WKHA/Cfd 5 157319671 173707219 2 - by one flank and peak markers 5 151113452 166875058 2 - by one flank and peak markers 631273 rat Lecl2 Lens clarity QTL 2 15 0.001 37308 D15Rat52 34471 D15Mgh3 lens clarity trait (VT:0001304) age of onset/diagnosis of cataract (CMO:0001584) cornea opacity Corneal Opacity;cataract 68701 11252169 recessive 15 21251142 66251142 4 - by one flank marker only 15 16458810 61458810 4 - by one flank marker only intercross IExWKY/Izm 631285 631286 IER/Ihr WKY/Izm 15 39480797 62596410 1 - by flanking markers 15 10596089 55596089 4 - by one flank marker only 631274 rat Sprol1 Serum protein level QTL 1 18 5.3 33814 D18Mit9 2741 Nr3c1 2715 Gnal blood total protein amount (VT:0005567) serum total protein level (CMO:0000661) increased circulating total protein level disease of metabolism 61055;61056 9199194;9241273 18 32348480 79748238 1 - by flanking markers 18 32459145 80370367 1 - by flanking markers intercross BB/OK;SHR/Mol 61107 61110 BB/OK SHR/Mol 18 32704022 80696226 1 - by flanking markers 18 31393320 77209694 1 - by flanking markers 631494 rat Bp95 Blood pressure QTL 95 1 40.0 1.0E-4 62499 D1Uia8 35517 D1Rat18 37598 D1Rat176 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 68885 11160999 3720 Slc9a3 Bp27 (interacts with);Bp30 (interacts with) 1 23257188 50297622 2 - by one flank and peak markers intercross SSxLEW 631571 SS.LEW-(D1Uia8-D1Mco38)/Jr 1 21300822 49454378 2 - by one flank and peak markers 1 16206210 49268520 2 - by one flank and peak markers 631495 rat Bp96 Blood pressure QTL 96 1 4.52 23.9 34662 D1Mgh2 33686 D1Mit11 34037 D1Mit1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619642;631172 9449402;12441404 additive 1 24875821 109100951 1 - by flanking markers 1 22842898 102532417 1 - by flanking markers intercross SBH/yxSBN/y 631572 631573 SBH/Ygl SBN/Ygl 1 23406428 108057505 1 - by flanking markers 1 22340647 102268831 1 - by flanking markers 631496 rat Bp97 Blood pressure QTL 97 1 3.08 30.0 34381 D1Mgh7 33646 D1Mit4 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619642;631172 9449402;12441404 additive 1 114600888 159600888 4 - by one flank marker only 1 106445165 163516043 2 - by one flank and peak markers intercross SBH/yxSBN/y 631572 631573 SBH/Ygl SBN/Ygl 1 113593576 158593576 4 - by one flank marker only 1 106047847 151047847 4 - by one flank marker only 631497 rat Bp98 Blood pressure QTL 98 17 3.66 12.6 34369 D17Mgh4 10348 D17Mit4 34120 D17Mgh5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619642 9449402 additive 17 36585991 65757501 2 - by one flank and peak markers 17 46994933 71214857 2 - by one flank and peak markers intercross SBH/yxSBN/y 631572 631573 SBH/Ygl SBN/Ygl 17 42956021 63994435 2 - by one flank and peak markers 17 41354651 60463643 2 - by one flank and peak markers 631498 rat Bp100 Blood pressure QTL 100 5 4.9 0.001 13.5 3193 Nppa 3194 Nppb 3194 Nppb arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619655 9171954 5 168455640 168466309 1 - by flanking markers 5 165063650 165074518 1 - by flanking markers backcross SHRxWKY 61000 61103 SHR WKY 5 164797538 164808407 1 - by flanking markers 5 158418175 158429042 1 - by flanking markers 631499 rat Stl1 Serum triglyceride level QTL 1 17 3.6 2091 Aldoc 45450 D17Wox3 34276 D17Mgh2 blood triglyceride amount (VT:0002644) blood triglyceride level (CMO:0000118) increased circulating triglyceride level Hypertriglyceridemia;arteriosclerosis 619656 11414700 17 5621596 29981162 2 - by one flank and peak markers 17 8933253 33639527 2 - by one flank and peak markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 17 3414039 28073589 2 - by one flank and peak markers 17 3271398 27389946 2 - by one flank and peak markers 631500 rat Bp99 Blood pressure QTL 99 2 2.5 6.9 2391 Cpb1 3407 Prlr 2071 Agtr1b arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619650 7852741 2 84554681 124787804 1 - by flanking markers 2 59701221 105413336 1 - by flanking markers intercross SS/JrxAS 10041 67958 SS/Jr AS 2 60325686 105059293 1 - by flanking markers 2 59324719 102755241 1 - by flanking markers 631501 rat Bp101 Blood pressure QTL 101 2 2.4 34461 D2Mgh12 33747 D2Mit10 33747 D2Mit10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 dominant 2 177277204 235592715 1 - by flanking markers 2 155920808 210636008 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 2 157914409 217498545 1 - by flanking markers 2 150341684 202446871 1 - by flanking markers 631502 rat Cm26 Cardiac mass QTL 26 17 3.71 34989 D17Rat39 35827 D17Rat52 35827 D17Rat52 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy Left Ventricular Hypertrophy 619658 11045938 dominant 17 71046400 86907303 1 - by flanking markers 17 76829512 92594341 1 - by flanking markers intercross LEW/CrjxSHR/Izm 631576 631577 LEW/CrlCrlj SHR/Izm 17 69333272 85183543 1 - by flanking markers 17 65703580 81153923 1 - by flanking markers 631503 rat Bp102 Blood pressure QTL 102 7 1.9 2868 Igf1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 recessive 7 6067956 51067956 5 - by peak with adj size 7 2068705 47068705 5 - by peak with adj size backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 7 5951969 50951969 5 - by peak with adj size 7 1 44822433 5 - by peak with adj size 631504 rat Cm27 Cardiac mass QTL 27 7 3.45 35122 D7Rat9 37258 D7Rat107 37642 D7Rat112 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) heart left ventricle hypertrophy;increased systemic arterial blood pressure Left Ventricular Hypertrophy;hypertension 619658 11045938 codominant 7 50717775 127783388 1 - by flanking markers 7 47865637 125399168 1 - by flanking markers intercross LEW/CrjxSHR/Izm 631576 631577 LEW/CrlCrlj SHR/Izm 7 50704769 128085642 1 - by flanking markers 7 44421311 118198041 1 - by flanking markers 631505 rat Bp103 Blood pressure QTL 103 5 3.2 3704 Slc2a1 34248 D5Mgh9 34443 D5Mgh8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 recessive 5 141964114 175858487 1 - by flanking markers 5 139690801 171801867 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 5 138154677 172402610 1 - by flanking markers 5 132717196 165560427 1 - by flanking markers 631506 rat Bp104 Blood pressure QTL 104 11 2.8 10376 D11Wox6 34112 D11Mgh4 3761 Sst arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619656 11414700 recessive 11 65784538 89808347 1 - by flanking markers 11 61504483 84560085 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 11 62653365 86714475 1 - by flanking markers 11 59802794 82566545 1 - by flanking markers 631507 rat Bp105 Blood pressure QTL 105 2 0.001 38626 D2Rat171 67315 D2Arb24 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) cardiac hypertrophy;increased systemic arterial blood pressure Cardiomegaly;hypertension 619651 11403354 2 135770850 248088631 1 - by flanking markers 2 116874922 221284686 1 - by flanking markers intercross 631578 SHR.BN-(D2Rat171-D2Arb24)/Ipcv 2 116075644 228737869 1 - by flanking markers 2 112456140 212696837 1 - by flanking markers 631508 rat Sald1 Serum aldosterone level QTL 1 1 3.7 36640 D1Rat14 blood aldosterone amount (VT:0005346) serum aldosterone level (CMO:0000487) increased circulating aldosterone level arteriosclerosis 629577 12482837 1 13895577 58895577 5 - by peak with adj size 17 1 24981037 5 - by peak with adj size BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 1 12493439 57493439 5 - by peak with adj size 1 9856001 54856001 5 - by peak with adj size 631509 rat Sald2 Serum aldosterone level QTL 2 18 2.9 37568 D18Rat55 35977 D18Rat8 blood aldosterone amount (VT:0005346) serum aldosterone level (CMO:0000487) increased circulating aldosterone level arteriosclerosis 629577 12482837 18 53346348 70825941 1 - by flanking markers 18 54856551 72450442 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 18 54108375 71692768 1 - by flanking markers 18 52539763 69140759 1 - by flanking markers 631510 rat Spl2 Serum phospholipid level QTL 2 11 4.1 35096 D11Rat10 blood phospholipid amount (VT:0006084) serum phospholipid level (CMO:0001171) hyperlipidemia arteriosclerosis;familial hyperlipidemia 629577 12482837 BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 631511 rat Pia7 Pristane induced arthritis QTL 7 4 4.3 10158 D4Arb16 34338 D4Mgh11 36143 D4Rat60 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 629570;629560;2307198;2300074;1582387;2324629;2302026;61067;61087 11090241;12571866;18540828;18606636;16804090;20200546;14674011;11001927;9600974 recessive Cia13 (maps to same region);Oia2 (maps to same region);Pia32 (interacts with) 4 196023944 230565226 1 - by flanking markers 4 133939407 171204531 1 - by flanking markers intercross 737950 2324631 DA/Ztm DA.E3-(D4Wox49-D4Got136)/Rhd 4 131532269 168047091 1 - by flanking markers 4 131730738 167139601 1 - by flanking markers 631512 rat Scl6 Serum cholesterol level QTL 6 1 9.6 35106 D1Rat335 36765 D1Rat27 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 1 68007159 95301868 1 - by flanking markers 1 71659707 90282193 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 1 67227683 94201552 1 - by flanking markers 1 72197680 90508767 1 - by flanking markers 631513 rat Scl7 Serum cholesterol level QTL 7 7 4.1 38198 D7Rat69 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 7 45491510 90491510 5 - by peak with adj size 7 42112081 87112081 5 - by peak with adj size BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 7 45301573 90301573 5 - by peak with adj size 7 37960569 82960569 5 - by peak with adj size 631514 rat Scl8 Serum cholesterol level QTL8 2 4.4 34858 D2Rat69 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 2 250313889 285068071 5 - by peak with adj size 2 224795742 258207540 5 - by peak with adj size BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 2 231621666 266435125 5 - by peak with adj size 631515 rat Bw10 Body weight QTL 10 10 3.5 10662 D10Wox23 61296 Aoc1 34330 D10Mgh2 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619656 11414700 10 84740741 110718848 2 - by one flank and peak markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 631516 rat Gluco31 Glucose level QTL 31 15 7.0 34160 D15Mgh5 34471 D15Mgh3 2536 Ednrb blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia 619656 11414700 15 66251142 106602088 1 - by flanking markers 15 61458810 102741229 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 15 62596410 103164962 1 - by flanking markers 15 55596089 95018120 1 - by flanking markers 631517 rat Scl9 Serum cholesterol level QTL 9 16 3.3 35005 D16Rat6 38370 D16Rat44 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia;arteriosclerosis 629577 12482837 16 17191679 22636409 1 - by flanking markers 16 16194598 22671959 1 - by flanking markers BC/CpbuxLew/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 16 17309396 22744540 1 - by flanking markers 16 15726433 21034895 1 - by flanking markers 631518 rat Bw11 Body weight QTL 11 18 2.8 3749 Spink1 45561 D18Wox18 45561 D18Wox18 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619656 11414700 18 37878841 82878841 4 - by one flank marker only 18 37135503 82135503 4 - by one flank marker only backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 18 38221919 83221919 4 - by one flank marker only 18 35870723 80870723 4 - by one flank marker only 631519 rat Pia11 Pristane induced arthritis QTL 11 1 5.3 13.0 38144 D1Rat185 10951 D1Mit13 34011 D1Mit2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2300074;1582387;2307198 12111642;18606636;16804090;18540828 recessive Pia14 (maps to same region);Pia9 (interacts with) 1 160649793 205649793 4 - by one flank marker only 1 83489176 186472032 2 - by one flank and peak markers Intercross E3xLEW.1F 61013 631581 E3 LEW.1F 1 153656062 198656062 4 - by one flank marker only 1 136830018 181830018 4 - by one flank marker only 631520 rat Bp73 Blood pressure QTL 73 2 1.0E-4 3098 Mme 10584 D2Wox18 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension;hypertension 631320;70380 12661916;11773968 70972 Hao2 Bp10 (interacts with);Bp19 (interacts with) 2 173193501 201402094 1 - by flanking markers 2 153031724 174727552 1 - by flanking markers intercross 631582 SS.WKY-(Mme-D2Wox18)/Mco 2 153799203 181987474 1 - by flanking markers 2 147686913 168355276 1 - by flanking markers 631521 rat Pia12 Pristane induced arthritis QTL 12 12 8.9 20.0 35384 D12Rat1 35889 D12Rat10 40986 D12Rat72 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2300074;1582387 12111642;18606636;16804090 recessive Pia4 (maps to same region) 12 6945260 28700508 1 - by flanking markers 12 555108 24748499 1 - by flanking markers Intercross E3xLEW.1F 61013 631581 E3 LEW.1F 12 23241246 26710128 2 - by one flank and peak markers 12 20259417 23672083 2 - by one flank and peak markers 631522 rat Bp74 Blood pressure QTL 74 2 0.05 34292 D2Mgh8 34234 D2Mgh9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 70380 11773968 2 206015127 218191419 1 - by flanking markers 2 179302449 191378271 1 - by flanking markers intercross 631583 SS.WKY-(D2Mgh8-D2Mgh9)/Mco 2 186611811 198704485 1 - by flanking markers 2 172710921 184114403 1 - by flanking markers 631523 rat Pia13 Pristane induced arthritis QTL 13 14 3.3 8.0 34839 D14Rat32 35723 D14Rat25 37230 D14Rat64 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2300074;1582387;2307198 12111642;18606636;16804090;18540828 recessive 14 42238587 108554989 1 - by flanking markers 14 43399833 105009429 1 - by flanking markers Intercross LEW.1FxE3 61013 631581 E3 LEW.1F 14 42442731 108833671 1 - by flanking markers 14 40793460 98037301 1 - by flanking markers 631524 rat Bp75 Blood pressure QTL 75 16 0.05 35475 D16Rat21 42409 D16Rat112 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70460;1300037 11919686;15080379 Bp248 (sub_region) 16 773569 11086530 1 - by flanking markers 16 64959 8413129 1 - by flanking markers backcross 631585 1358168 SS.LEW-(D16Mit2-D16Rat12)/Ayd SS.LEW-(D16Mit2-D16Chm23)/Ayd 16 1 778655 4 - by one flank marker only 16 1 110831 4 - by one flank marker only 631525 rat Pia14 Pristane induced arthritis QTL 14 16 4.4 19.0 39390 D16Rat64 60771 D16Wox8 38428 D16Rat53 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631225;2307198;2300074;1582387 12111642;18540828;18606636;16804090 recessive Pia11 (maps to same region) 16 58966446 88650497 1 - by flanking markers 16 59398206 88891349 1 - by flanking markers Intercross E3xLEW.1F 61013 631581 E3 LEW.1F 16 59285775 89248943 1 - by flanking markers 16 55711087 83402471 1 - by flanking markers 631526 rat Bp76 Blood pressure QTL 76 10 1.0E-4 66552 D10Mco1 34445 D10Mgh6 3185 Nos2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure;decreased systemic arterial blood pressure hypertension 619625;61039;619626 9607182;7537756;9096100 10 63366218 68786307 1 - by flanking markers 10 67678060 69986912 1 - by flanking markers backcross 10041 60992 SS/Jr MNS 10 64648311 69123603 1 - by flanking markers 10 61345413 66743655 1 - by flanking markers 631527 rat Tls1 T-lymphoma susceptibility QTL 1 5 0.0 0.001 33981 D5Mit4 11302 D5Mit7 11302 D5Mit7 thymus integrity trait (VT:0010555) post-insult time to onset of T-cell lymphoma (CMO:0001907) increased T cell derived lymphoma incidence T-cell non-Hodgkin lymphoma 619600 10360666 5 97315057 142315057 4 - by one flank marker only 5 94515803 139515803 4 - by one flank marker only backcross LE/StmxF344 70509 629500 F344/NRrrc LEXF/Stm 5 93273130 138273130 4 - by one flank marker only 5 90450144 135450144 4 - by one flank marker only 631528 rat Scl11 Serum cholesterol level QTL 11 14 4.9 60764 D14Wox4 2065 Afp 2667 Gc blood cholesterol amount (VT:0000180) blood total cholesterol level (CMO:0000051) increased circulating cholesterol level Hypercholesterolemia 619656 11414700 14 19067260 38099442 1 - by flanking markers 14 19110728 38152541 1 - by flanking markers backcross WildxSHR/Mol 61110 631574 SHR/Mol Wild/K 14 19159919 38289187 1 - by flanking markers 14 17573412 19726296 2 - by one flank and peak markers 631529 rat Tls2 T-lymphoma susceptibility QTL 2 7 0.0 0.001 11164 D7Wox24 33648 D7Mit5 33969 D7Mit4 thymus integrity trait (VT:0010555) percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911) increased T cell derived lymphoma incidence T-cell non-Hodgkin lymphoma 619600 10360666 7 88393619 120429563 2 - by one flank and peak markers 7 85090032 137838850 1 - by flanking markers backcross LE/StmxF344 70509 629500 F344/NRrrc LEXF/Stm 7 88365265 119318087 2 - by one flank and peak markers 7 80221299 109401111 2 - by one flank and peak markers 631530 rat Tls3 T-lymphoma susceptibility QTL 3 10 0.0 1.0E-4 34100 D10Mgh3 34669 D10Mgh20 34445 D10Mgh6 thymus integrity trait (VT:0010555) percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911) increased T cell derived lymphoma incidence T-cell non-Hodgkin lymphoma 619600 10360666 10 53376848 98640137 1 - by flanking markers 10 53781298 100090301 1 - by flanking markers backcross LE/StmxF344 70509 629500 F344/NRrrc LEXF/Stm 10 53625815 98939209 1 - by flanking markers 10 51774612 95600334 1 - by flanking markers 631531 rat Iresp2 Immunoglobin response QTL2 10 6.3 13.0 35001 D10Rat43 36179 D10Rat34 44715 D10Wox26 blood immunoglobulin E amount (VT:0002492) serum immunoglobulin E level (CMO:0002101) increased IgE level allergic disease 619646 10898507 additive 10 22266756 32523945 1 - by flanking markers 10 23428127 32725718 1 - by flanking markers intercross LEW/RjxBN/Rj 1331823 LEW.BN-(D10Rat43-D10Rat27)/Rj 10 22402817 38204229 2 - by one flank and peak markers 10 22918268 36400810 2 - by one flank and peak markers 631532 rat Cm50 Cardiac mass QTL 50 10 6.6 60753 D10Wox3 10949 D10Wox11 34053 D10Mit3 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight hypertension 619631 10051321 10 18130297 53388667 1 - by flanking markers 10 18217625 53793117 1 - by flanking markers intercross BN.SS/Jr 10041 60985 SS/Jr BN 10 18246394 53637634 1 - by flanking markers 10 17907113 51786432 1 - by flanking markers 631533 rat Iresp3 Immunoglobin response QTL3 9 16.2 31.0 34264 D9Mgh5 60669 D9Got8 blood immunoglobulin E amount (VT:0002492) serum immunoglobulin E level (CMO:0002101) increased IgE level allergic disease 619646;69712 10898507;10072499 additive Eae4 (maps to same region) 9 1 37250901 2 - by one flank and peak markers 9 2176482 5446654 2 - by one flank and peak markers intercross LEW/RjxBN/Rj 631593 631594 LEW/Rj BN/Rj 9 2005583 3309921 2 - by one flank and peak markers 9 2745799 5857951 2 - by one flank and peak markers 631534 rat Lnnr1 Liver neoplastic nodule remodeling QTL 1 7 3.85 0.001 36099 D7Rat25 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705) decreased liver tumor incidence Experimental Liver Neoplasms 629574;1358145 12672032;15771619 2185;2868;3130;3377 Avpr1a;Igf1;Myc;Ppp1cc 7 41096572 86096572 5 - by peak with adj size 7 38076588 83076588 5 - by peak with adj size BNxF344 60985 70509 BN F344/NRrrc 7 40872682 85872682 5 - by peak with adj size 7 34293282 79293282 5 - by peak with adj size 631535 rat Cm51 Cardiac mass QTL 51 10 3.0 10949 D10Wox11 44786 D10Wox6 44773 D10Wox5 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight hypertension 619631 10051321 10 53388518 98370512 2 - by one flank and peak markers 10 53792967 96584953 2 - by one flank and peak markers intercross MNS.SS/Jr 10041 60992 SS/Jr MNS 10 53637485 94807701 2 - by one flank and peak markers 10 51786282 91669536 2 - by one flank and peak markers 631536 rat Lnnr2 Liver neoplastic nodule remodeling QTL 2 1 2.9 5.0E-4 34194 D1Mgh14 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705) decreased liver tumor incidence Experimental Liver Neoplasms 629574;1358145 12672032;15771619 2056;2059;2456;1587390 Adra2a;Adrb1;Cyp17a1;Prkg1 recessive 1 263104834 290094216 5 - by peak with adj size 1 241199027 267910886 5 - by peak with adj size BNxF344 60985 70509 BN F344/NRrrc 1 255728828 282763074 5 - by peak with adj size 1 233948574 260522016 5 - by peak with adj size 631537 rat Oia4 Oil induced arthritis QTL 4 10 35513 D10Rat24 11137 D10Wox17 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 62404;2307198;2306769 11230175;18540828;19299744 Ean4 (maps to same region);Oia3 (maps to same region);Oia5 (maps to same region);Oia6 (interacts with) 10 78194957 89831596 1 - by flanking markers 10 79229067 91168491 1 - by flanking markers 631596 LEW.1AV1.DA-(D10Rat92-D10Wox17)/Ubc 10 78343027 90042115 1 - by flanking markers 10 75631887 87055282 1 - by flanking markers 631538 rat Oia5 Oil induced arthritis QTL 5 10 11137 D10Wox17 34128 D10Mgh1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 62404;2307198 11230175;18540828 Oia3 (maps to same region);Oia4 (maps to same region);Oia6 (maps to same region) 10 89831438 112200500 4 - by one flank marker only 10 91168332 110718848 4 - by one flank marker only 631597 LEW.1AV1.DA-(D10Wox17-D10Rat135)/Ubc 10 90041957 112626471 4 - by one flank marker only 10 87055121 107211142 4 - by one flank marker only 631539 rat Oia6 Oil induced arthritis QTL 6 10 44836 D10Got154 41584 D10Rat135 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 62404;2307198 11230175;18540828 Oia3 (maps to same region);Oia4 (interacts with);Oia5 (maps to same region) 10 100150192 108145987 1 - by flanking markers 10 101532360 108776963 1 - by flanking markers 631598 LEW.1AV1.DA-(D10Got154-D10Rat135)/Ubc 10 100460820 108540162 1 - by flanking markers 10 97010147 104670812 1 - by flanking markers 631540 rat Bw9 Body weight QTL 9 7 4.5 10075 D7Mgh2 34499 D7Mgh7 10937 D7Wox15 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619631 10051321 7 77531259 128787635 2 - by one flank and peak markers 7 74244786 123665486 2 - by one flank and peak markers intercross BN.SS/Jr 10041 60985 SS/Jr BN 7 77428105 127748511 2 - by one flank and peak markers 7 69736226 117455174 2 - by one flank and peak markers 631541 rat Bp81 Blood pressure QTL 81 3 4.0 10668 D3Wox4 43691 D3Wox20 34316 D3Mgh2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased heart weight;increased systemic arterial blood pressure hypertension 619631 10051321 3 136268218 183740530 2 - by one flank and peak markers 3 124893448 171063335 2 - by one flank and peak markers intercross BNxSS/Jr 10041 60985 SS/Jr BN 3 129787213 177699992 2 - by one flank and peak markers 3 124122556 169034231 2 - by one flank and peak markers 631542 rat Bp82 Blood pressure QTL 82 10 6.8 33632 D10Mit10 44839 D10Wox7 11479 D10Mit8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased heart weight;increased systemic arterial blood pressure hypertension 619631 10051321 10 27082535 102101375 1 - by flanking markers 10 27184741 103551039 1 - by flanking markers intercross MNSxSS/Jr 10041 60992 SS/Jr MNS 10 27237530 102427718 1 - by flanking markers 10 26521957 98952741 1 - by flanking markers 631543 rat Bp83 Blood pressure QTL 83 12 5.8 45014 D12Wox8 33776 D12Mit3 60755 D12Wox16 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619631 10051321 12 19226299 45929887 2 - by one flank and peak markers 12 16535858 39626712 2 - by one flank and peak markers intercross MNSxSS/Jr 10041 61103 SS/Jr WKY 12 17185580 44098244 2 - by one flank and peak markers 12 15550826 38478808 2 - by one flank and peak markers 631544 rat Bp84 Blood pressure QTL 84 1 5.6 21.0 60784 D1Wox29 3750 Spn 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal baroreceptor physiology;increased systemic arterial blood pressure hypertension 619634;2302408;1302892 10604486;19047583;15480093 Cstrr1 (sub_region) 1 131822204 205576290 1 - by flanking markers 1 124614679 186391887 1 - by flanking markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 1 130779148 198585664 1 - by flanking markers 1 123350408 181759564 1 - by flanking markers 631545 rat Bp85 Blood pressure QTL 85 3 3.1 34198 D3Mgh8 34347 D3Mgh16 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619634 10604486 3 1 33861758 5 - by peak with adj size 3 1 28873394 5 - by peak with adj size intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 3 1 28500807 5 - by peak with adj size 3 1 33278763 5 - by peak with adj size 631546 rat Bp86 Blood pressure QTL 86 4 3.2 33757 D4Mit2 33905 D4Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619634 10604486 4 55539015 157291359 1 - by flanking markers 4 55369931 91330856 1 - by flanking markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 4 55791564 92484312 1 - by flanking markers 4 57114432 91360801 1 - by flanking markers 631547 rat Bp87 Blood pressure QTL 87 10 4.5 34128 D10Mgh1 34485 D10Mgh4 33941 D10Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619634 10604486 10 50372987 95372987 4 - by one flank marker only 10 96799833 106897319 2 - by one flank and peak markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 10 50638337 95638337 4 - by one flank marker only 10 47369470 92369470 4 - by one flank marker only 631548 rat Bp88 Blood pressure QTL 88 1 5.0 0.001 36105 D1Rat51 3640 Scnn1b 631293 D1M7Mit236 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 619643 10523340 Bp30 (maps to same region) 1 173583273 198953453 1 - by flanking markers 1 159782445 180748068 1 - by flanking markers intercross WKYxSHRSP 631600 WKY.SHRSP-(Mt1pa-D1Rat200)/Bbb 1 167394665 191883991 1 - by flanking markers 1 156677124 176484451 1 - by flanking markers 631549 rat Bp89 Blood pressure QTL 89 1 5.7 36580 D1Rat112 60784 D1Wox29 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619635 10779121 1 131822376 226109127 1 - by flanking markers 1 124614852 206574205 1 - by flanking markers backcross WKYxSHRSP 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb 1 130779320 219238476 1 - by flanking markers 1 123350581 201284552 1 - by flanking markers 631550 rat Bw7 Body weight QTL 7 15 3.6 36313 D15Rat5 40674 D15Rat86 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 629577 12482837 15 24970714 44894842 1 - by flanking markers 15 22452603 39869843 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 15 21021342 41082727 1 - by flanking markers 15 19856566 34924750 1 - by flanking markers 631551 rat Vetf1 Vascular elastic tissue fragility QTL 1 5 5.0 1.0E-4 37784 D5Rat59 37596 D5Rat118 39686 D5Rat119 aorta elastic tissue integrity trait (VT:0010556) artery internal elastic lamina non-tumorous lesion count (CMO:0001913) abnormal susceptibility to atherosclerosis atherosclerosis 619605;8662443 11526202;17356016 621017 Lyn Vetf3 (maps to same region) 5 1662934 10373154 1 - by flanking markers 5 1368223 5112800 1 - by flanking markers BN/PitxGH/Omr 10016 631602 GH/Omr BN/Elh 5 1666587 5533324 1 - by flanking markers 5 2282226 5904428 1 - by flanking markers 631552 rat Vetf2 Vascular elastic tissue fragility QTL 2 10 4.5 2.0E-4 34318 D10Mgh10 10466 D10Mit1 33846 D10Mit2 aorta elastic tissue integrity trait (VT:0010556) artery internal elastic lamina non-tumorous lesion count (CMO:0001913) abnormal susceptibility to atherosclerosis atherosclerosis 619605;8662443 11526202;17356016 3742 Sparc dominant Vetf10 (maps to same region) 10 35954931 93929812 1 - by flanking markers 10 36254741 95369088 1 - by flanking markers BN/PitxGH/Omr 10016 631602 GH/Omr BN/Elh 10 36185929 95845311 2 - by one flank and peak markers 10 41142633 86142633 5 - by peak with adj size 631554 rat Bp133 Blood pressure QTL 133 10 0.005 3136 Myh11 3185 Nos2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619633;2312779 7568016;15800376 dominant Bp1 (maps to same region) 10 11444263 65456957 1 - by flanking markers 10 666709 65072453 1 - by flanking markers backcross WKYxSHRSP 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb 10 764421 66221621 1 - by flanking markers 10 743364 63851208 1 - by flanking markers 631555 rat Bp134 Blood pressure QTL 134 10 0.001 3177 Ngfr 2686 Gh1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619633;2312779 7568016;15800376 dominant Bp1 (maps to same region) 10 83198396 94239391 1 - by flanking markers 10 84262804 95694117 1 - by flanking markers backcross WKYxSHRSP 631601 WKY.SHRSP-(Asgr1-Vamp2)/Bbb 10 83389828 94488181 1 - by flanking markers 10 80515287 91230079 1 - by flanking markers 631556 rat Bp135 Blood pressure QTL 135 4 0.017 3197 Npy 3753 Spr 3197 Npy arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 631181 8476428 dominant 4 144233753 181496612 1 - by flanking markers 4 78038013 119369308 1 - by flanking markers intercross WKY/SnkxSHR/Snk 631603 631604 WKY/Snk SHR/Snk 4 79557856 116916073 1 - by flanking markers 4 78881294 117676292 1 - by flanking markers 631557 rat Bp136 Blood pressure QTL 136 10 0.003 66469 D10Mco58 35513 D10Rat24 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 628510;1643425 11641286;18175179 3185 Nos2 10 33195122 78195122 4 - by one flank marker only 10 34229233 79229233 4 - by one flank marker only Intercross 631605 SS.LEW-(D10Arb9-D10Got101)/Jr 10 33343192 78343192 4 - by one flank marker only 10 30632053 75632053 4 - by one flank marker only 631558 rat Bp137 Blood pressure QTL 137 10 0.013 35627 D10Rat12 66520 D10Mco70 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 628510 11641286 10 97758850 99977168 1 - by flanking markers 10 99198838 101355916 1 - by flanking markers Intercross 631606 SS.MNS-(D10Rat13-D10Mit11)/Jr 10 98044675 100287699 1 - by flanking markers 10 94724860 96836268 1 - by flanking markers 631559 rat Hcuc1 Hepatic copper content QTL 1 10 3.0 liver copper amount (VT:0003065) liver copper weight to liver dry weight ratio (CMO:0001512) increased liver copper level Wilson disease;liver disease 619607;629572 11741328;12094018 621684 Atox1 Hcuc4 (maps to same region) SHR/OlaIpcv||BN-Lx/Cub 68049 HXB-1-43/Ipcv 631560 rat Apr1 Acute phase response QTL 1 12 6.1 11396 D12Mgh11 orosomucoid 1 amount (VT:0010541) plasma orosomucoid 1 level (CMO:0001467) abnormal acute phase protein level rheumatoid arthritis 629561;2300074;1582387;2307198;2302026 11817600;18606636;16804090;18540828;14674011 recessive Pia37 (maps to same region) 12 26700760 54450796 5 - by peak with adj size 12 20418353 46782294 5 - by peak with adj size E3xDA 60997 61013 DA E3 12 24906590 52716770 5 - by peak with adj size 12 19144362 46669029 5 - by peak with adj size 631561 rat Hcuc2 Hepatic copper content QTL 2 16 2.8 10885 D16Wox9 liver copper amount (VT:0003065) liver total copper weight (CMO:0001507) increased liver copper level Wilson disease;liver disease 619607 11741328 16 1 41109553 5 - by peak with adj size 16 1 40096622 5 - by peak with adj size SHR/OlaIpcvxBN-Lx/Cub 68049 HXB-1-43/Ipcv 16 1 41240957 5 - by peak with adj size 16 1 39533949 5 - by peak with adj size 631562 rat Apr2 Acute phase response QTL 2 5 3.7 11001 D5Wox10 blood murinoglobulin 1 amount (VT:0010597) plasma murinoglobulin 1 level (CMO:0001931) abnormal acute phase protein level rheumatoid arthritis 629561;2300074;1582387;2307198 11817600;18606636;16804090;18540828 dominant 5 145965224 177180328 5 - by peak with adj size 5 142573432 173096209 5 - by peak with adj size E3xDA 60997 61013 DA E3 5 142307322 173707219 5 - by peak with adj size 5 135927956 166875058 5 - by peak with adj size 631563 rat Hcuc3 Hepatic copper content QTL 3 2 3.87 37552 D2Rat185 40128 D2Rat241 liver copper amount (VT:0003065) liver copper weight to liver dry weight ratio (CMO:0001512) increased liver copper level Wilson disease;liver disease 629572 12094018 2838 Hsd3b5 recessive 2 242993417 264423632 1 - by flanking markers 2 217985582 238139978 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 2 245893572 266435125 4 - by one flank marker only 2 229059610 249053267 4 - by one flank marker only 631564 rat Apr3 Acute phase response QTL 3 10 3.9 10794 D10Mgh9 blood interleukin-6 amount (VT:0008595) plasma interleukin-6 level (CMO:0001927) abnormal circulating interleukin-6 level rheumatoid arthritis 629561 11817600 additive 10 16250463 61250463 5 - by peak with adj size 10 16579339 61579339 5 - by peak with adj size E3xDA 60997 61013 DA E3 10 16468736 61468736 5 - by peak with adj size 10 15275955 60275955 5 - by peak with adj size 631565 rat Hcuc4 Hepatic copper content QTL 4 10 4.15 36203 D10Rat27 38936 D10Rat98 liver copper amount (VT:0003065) liver copper weight to liver dry weight ratio (CMO:0001512) increased liver copper level Wilson disease;liver disease 629572 12094018 621684 Atox1 recessive Hcuc1 (maps to same region) 10 68983854 74127825 1 - by flanking markers 10 70191595 77091834 1 - by flanking markers BC/CpbuxLEW/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 10 69348459 75983662 1 - by flanking markers 10 66941813 73452992 1 - by flanking markers 631566 rat Bp90 Blood pressure QTL 90 2 1.0E-4 61323 D2N35 3098 Mme arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619640 9541488 2 128278946 173278946 4 - by one flank marker only 2 108114515 153114515 4 - by one flank marker only backcross SS/JrxWKY 631607 SS.WKY-(D2N35-Mme)/Mco 2 108880910 153880910 4 - by one flank marker only 2 102803808 147803808 4 - by one flank marker only 631567 rat Bp91 Blood pressure QTL 91 10 1.0E-4 631289 D10M11Mit119 33941 D10Mit11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619640 9541488 10 55446730 100446730 4 - by one flank marker only 10 56848683 101848683 4 - by one flank marker only backcross SS/JrxMNS 629505 SS.MNS-(D10Mit11-D10M11Mit119)/Mco 631568 rat Bp92 Blood pressure QTL 92 3 2.2 0.005 9.8 35609 D3Rat53 35947 D3Rat45 35609 D3Rat53 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61516 11015598 additive 3 1 40956181 5 - by peak with adj size 3 1 38709732 4 - by one flank marker only intercross SS/JrxSHR 10041 724574 SS/Jr SHR/NHsd 3 13126914 41510346 1 - by flanking markers 3 1 39874793 5 - by peak with adj size 631569 rat Bp93 Blood pressure QTL 93 1 1.0E-4 34381 D1Mgh7 66611 D1Mco36 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 68885;9685377;2291850 11160999;25231251;18324438 additive Bp27 (interacts with);Bp30 (interacts with) 1 114600888 130268180 1 - by flanking markers 1 106445165 122992360 1 - by flanking markers intercross SSxLEW 728165 SS.LEW-(D1Rat196-D1Mco36)/Jr 1 113593576 129209407 1 - by flanking markers 1 106047847 121834139 1 - by flanking markers 631570 rat Bp94 Blood pressure QTL 94 1 1.0E-4 36432 D1Rat35 38296 D1Rat131 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 68885;2291850 11160999;18324438 additive Bp27 (interacts with);Bp30 (interacts with);Bp313 (sub_region);Bp314 (sub_region) 1 131958920 159182239 1 - by flanking markers 1 124748920 145648920 1 - by flanking markers backcross SSxLEW 631610 SS.LEW-(D1Rat39-D1Rat131)/Jr 1 130917121 152871103 1 - by flanking markers 1 123479780 142990467 1 - by flanking markers 631642 rat Stl2 Serum triglyceride level QTL 2 4 3.3 33656 D4Mit9 2901 Il6 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 619667 9633608 4 3100112 55067578 1 - by flanking markers 4 461376 54828069 1 - by flanking markers SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 4 3047807 55324857 1 - by flanking markers 4 5219178 56647776 1 - by flanking markers 631643 rat Bp120 Blood pressure QTL 120 9 3.0 0.004 1334445 D9Wox18 33842 D9Mit6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 9 24554204 69554204 4 - by one flank marker only 9 1526958 18347599 1 - by flanking markers SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 9 25692373 70692373 4 - by one flank marker only 9 22071200 67071200 4 - by one flank marker only 631645 rat Bp121 Blood pressure QTL 121 13 3.3 34351 D13Mgh4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 13 24916143 69916143 5 - by peak with adj size 13 15989872 60989872 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 13 19810814 64810814 5 - by peak with adj size 13 14915655 59915655 5 - by peak with adj size 631646 rat Stl4 Serum triglyceride level QTL 4 4 6.5 1.0E-4 17.9 33711 D4Mit5 34001 D4Mit17 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating insulin level;increased circulating triglyceride level Hypertriglyceridemia;hyperinsulinism 631174 12687333 4 138480612 196943890 1 - by flanking markers 4 72160227 134858710 1 - by flanking markers intercross hHTGxBN 1302795 1354669 HTG BN/OrlIcoCrlf 4 73786419 132455556 1 - by flanking markers 4 73169846 132642728 1 - by flanking markers 631647 rat Bp122 Blood pressure QTL 122 3 6.2 34146 D3Mgh6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 3 38749889 83749889 5 - by peak with adj size 3 28022667 73022667 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 3 32130997 77130997 5 - by peak with adj size 3 30684642 75684642 5 - by peak with adj size 631648 rat Stl5 Serum triglyceride level QTL 5 8 4.0 3.0E-4 41522 D8Rat164 44441 D8Wox3 33913 D8Mit13 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia 631174 12687333 additive 8 29878681 62336643 2 - by one flank and peak markers 8 28414004 58991068 2 - by one flank and peak markers intercross hHTGxBN 1302795 1354669 HTG BN/OrlIcoCrlf 8 29867983 59908353 2 - by one flank and peak markers 8 27205715 54998217 2 - by one flank and peak markers 631649 rat Bp123 Blood pressure QTL 123 3 3.2 34250 D3Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 3 101312247 146312247 5 - by peak with adj size 3 89819539 134819539 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 3 94788365 139788365 5 - by peak with adj size 3 89772419 134772419 5 - by peak with adj size 631650 rat Stl6 Serum triglyceride level QTL 6 8 4.0 0.0019 36235 D8Rat35 34180 D8Mgh1 34415 D8Mgh6 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia 631174 12687333 additive 8 65325025 119835296 1 - by flanking markers 8 64616911 116844692 1 - by flanking markers intercross hHTGxBN 1302795 1354669 HTG BN/OrlIcoCrlf 8 10938911 120496129 2 - by one flank and peak markers 8 10378157 112202585 2 - by one flank and peak markers 631651 rat Bp124 Blood pressure QTL 124 4 3.0 35409 D4Rat34 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 4 128590766 173590766 5 - by peak with adj size 4 62514126 107514126 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 4 63938412 108938412 5 - by peak with adj size 4 62879517 107879517 5 - by peak with adj size 631652 rat Bp106 Blood pressure QTL 106 10 3671 Shbg 2171 Atp1b2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629620 12566390 10 55957510 55965499 1 - by flanking markers 10 56424465 56432474 1 - by flanking markers 728139 WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb 10 56211879 56219861 1 - by flanking markers 10 54324933 54332939 1 - by flanking markers 631653 rat Bp125 Blood pressure QTL 125 8 3.3 33895 D8Mit1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 8 72350448 117350448 5 - by peak with adj size 8 70474667 115474667 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 8 72849686 117849686 5 - by peak with adj size 8 66142385 111142385 5 - by peak with adj size 631654 rat Bp107 Blood pressure QTL 107 1 37428 D1Rat200 39314 D1Rat216 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629620 12566390 1 134116233 205161264 1 - by flanking markers 1 126938969 185923619 1 - by flanking markers 631694 728139 WKY.SHRSP-(D1Rat200-D1Rat216)/Bbb WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb 1 133076978 178076978 4 - by one flank marker only 1 125611501 170611501 4 - by one flank marker only 631655 rat Bp126 Blood pressure QTL 126 15 4.0 2536 Ednrb arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 15 69016189 114016189 5 - by peak with adj size 15 65395920 109758846 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 15 65520564 110520564 5 - by peak with adj size 15 58156477 101769107 5 - by peak with adj size 631656 rat Bp108 Blood pressure QTL 108 9 5.97 1.0E-4 36556 D9Rat10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629621;2302803 12775577;18854752 Bp333 (maps to same region);Bp334 (interacts with) 9 53957431 98957431 5 - by peak with adj size 9 45992963 90992963 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 9 54177542 99177542 5 - by peak with adj size 9 48598251 93598251 5 - by peak with adj size 631658 rat Cm7 Cardiac mass QTL 7 1 5.32 1.0E-4 36866 D1Rat73 aorta mass (VT:0002845) aorta weight (CMO:0000076) abnormal aortic weight heart disease;hypertension 629621 12775577 1 223613389 268613389 5 - by peak with adj size 1 201920676 246920676 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 1 216324817 261324817 5 - by peak with adj size 1 196248093 241248093 5 - by peak with adj size 631660 rat Hcar1 Hepatocarcinoma resistance QTL 1 10 3.4 1.0E-4 34318 D10Mgh10 38062 D10Rat96 36542 D10Rat51 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms 619598 10493520 3112;3889 Abcc1;Tp53 dominant 10 5044836 35954931 1 - by flanking markers 10 6172805 36254741 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 10 6229289 36185929 1 - by flanking markers 10 6154182 15990232 2 - by one flank and peak markers 631662 rat Hcar2 Hepatocarcinoma resistance QTL 2 4 3.1 3.0E-4 11011 D4Mgh4 36554 D4Rat47 35817 D4Rat40 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms 619598 10493520 2794;3082;3849 Hgf;Met;Tgfa 4 144230964 187610582 2 - by one flank and peak markers 4 78035196 135074488 2 - by one flank and peak markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 4 79555067 124555067 4 - by one flank marker only 4 78878504 123878504 4 - by one flank marker only 631663 rat Bw6 Body weight QTL 6 7 3.4 39048 D7Rat94 35921 D7Rat12 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 629577 12482837 7 120739452 143465961 1 - by flanking markers 7 142816042 143002779 4 - by one flank marker only BC/CpbuxLew/OlaHsd 10004 631579 BC/CpbU LEW/OlaHsd 7 120746024 145692398 1 - by flanking markers 7 111075573 134976056 1 - by flanking markers 631664 rat Hcar3 Hepatocarcinoma resistance QTL 3 8 2.9 5.0E-4 36161 D8Rat36 11222 D8Mgh3 34870 D8Rat18 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms 619598 10493520 2458;2459;3845 Cyp1a1;Cyp1a2;Tf 8 57006784 105968579 1 - by flanking markers 8 57308572 103684785 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 8 58425510 106526740 1 - by flanking markers 8 54237644 99103503 1 - by flanking markers 631665 rat Bw8 Body weight QTL 8 3 5.5 11499 D3Wox23 11261 D3Wox9 34242 D3Mgh13 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619631 10051321 3 58456486 131007629 1 - by flanking markers 3 47722628 119673738 1 - by flanking markers intercross MNS.SS/Jr 10041 60992 SS/Jr MNS 3 51821836 124513579 1 - by flanking markers 3 50437042 119183768 1 - by flanking markers 631666 rat Iddm5 Insulin dependent diabetes mellitus QTL 5 X 3415 Prps2 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 625443 8586150 X 6350189 51350189 5 - by peak with adj size X 24794818 69794818 5 - by peak with adj size 60997 61107 DA BB/OK X 5954078 50954078 5 - by peak with adj size X 4494549 49494549 5 - by peak with adj size 631667 rat Iddm6 Insulin dependent diabetes mellitus QTL 6 1 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 625443 8586150 60997 61107 DA BB/OK 631668 rat Iddm7 Insulin dependent diabetes mellitus QTL 7 X blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 631165 9080298 BB-DP/HrixBN/Mol 631697 631698 BBDP/Hri BN/Mol 631669 rat Iddm9 Insulin dependent diabetes mellitus QTL 9 1 2.8 0.039 10674 D1Mgh12 33844 D1Mit14 10805 D1Mgh13 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 61077;6903877;2303106 9571179;9858659;19168599 Iddm25 (maps to same region) 1 270716905 287992330 1 - by flanking markers 1 247322146 266002939 1 - by flanking markers backcross BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 1 252955158 280632620 2 - by one flank and peak markers 1 233190394 258625266 2 - by one flank and peak markers 631670 rat Iddm10 Insulin dependent diabetes mellitus QTL 10 1 1.9 62086 Acsm3 3643 Sct 3750 Spn blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 6903877;2303106 9858659;19168599 Iddm25 (maps to same region) 1 196449042 221191992 1 - by flanking markers 1 178054386 201472944 1 - by flanking markers BB/OKxSHR/Mol 61107 61110 BB/OK SHR/Mol 1 189514504 214277437 1 - by flanking markers 1 174133260 196383668 1 - by flanking markers 631671 rat Iddm11 Insulin dependent diabetes mellitus QTL 11 4 3.6 0.0012 43795 D4Wox10 11012 D4Wox22 33711 D4Mit5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level;insulitis;pancreas inflammation Chronic Pancreatitis;Experimental Diabetes Mellitus 61480;1600776;1358925 9892222;17376830;14727142 Iddm14 (maps to same region) 4 57068808 144252646 1 - by flanking markers 4 56920444 78042833 1 - by flanking markers (WF/CrCrl x BBDP/WorBrm)x WF/CrCrl 1642018 2311079 BBDP/WorBrm WF/CrCrl 4 57307075 79578854 1 - by flanking markers 4 58635877 78886137 1 - by flanking markers 631672 rat Iddm12 Insulin dependent diabetes mellitus QTL 12 13 2.2 0.0032 33923 D13Mit1 34371 D13Mgh3 34076 D13Mgh1 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level Experimental Diabetes Mellitus 61480 9892222 2199 Bcl2 13 14281836 44494565 1 - by flanking markers 13 25430110 35472503 1 - by flanking markers (WF/CrCrl x BBDP/WorBrm)x WF/CrCrl 1642018 2311079 BBDP/WorBrm WF/CrCrl 13 9016742 39373058 1 - by flanking markers 13 5994668 34535351 1 - by flanking markers 631673 rat Iddm13 Insulin dependent diabetes mellitus QTL 13 3 1.3 0.663 33808 D3Mit4 34240 D3Mgh1 10502 D3Mgh10 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level Experimental Diabetes Mellitus 61480;2296064 9892222;18453595 Eau4 (maps to same region) 3 143321230 176999932 1 - by flanking markers 3 131188558 163778754 1 - by flanking markers (WF/CrCrl x BBDP/WorBrm)x WF/CrCrl 1642018 2311079 BBDP/WorBrm WF/CrCrl 3 136876155 170935007 1 - by flanking markers 3 130193298 161695983 1 - by flanking markers 631674 rat Iddm14 Insulin dependent diabetes mellitus QTL 14 4 42164 D4Arb29 10524 D4Mit3 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) increased circulating glucose level type 1 diabetes mellitus 61479;1358925;2305928;1600776;1358924;1304485;61480;2313174 10535446;14727142;19205800;17376830;15793267;12401717;9892222;19720792 Iddm11 (maps to same region);Iddm37 (interacts with) 4 63250011 224304222 1 - by flanking markers 4 63276741 160891592 1 - by flanking markers BB/DRxWF 1641868 WF.BBDR-(D4Rat93-D4Rat228)/Wor 4 63537179 157286626 1 - by flanking markers 4 64528739 157573521 1 - by flanking markers 631675 rat Iddm15 Insulin dependent diabetes mellitus QTL 15 18 2715 Gnal 33814 D18Mit9 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) decreased circulating glucose level;decreased urine glucose level diabetes mellitus 619685 11327715 18 61991738 79748387 1 - by flanking markers 18 63595606 80370517 1 - by flanking markers BB/OKxSHR 631700 BB.SHR-(Gnal-D18Mit9)/K 18 62805406 80696375 1 - by flanking markers 18 60622311 77209844 1 - by flanking markers 631676 rat Cm8 Cardiac mass QTL 8 3 7.03 1.0E-4 34336 D3Mgh7 aorta mass (VT:0002845) aorta weight (CMO:0000076) abnormal aortic weight heart disease;hypertension 629621 12775577 3 23109820 68109820 5 - by peak with adj size 3 14056777 59056777 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 3 18023664 63023664 5 - by peak with adj size 3 16954708 61954708 5 - by peak with adj size 631677 rat Iddm16 Insulin dependent diabetes mellitus QTL 16 6 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 61077 9571179 backcross BB/OKxDA 60997 61107 DA BB/OK 631678 rat Cm9 Cardiac mass QTL 9 19 4.27 1.0E-4 35567 D19Rat18 aorta mass (VT:0002845) aorta weight (CMO:0000076) abnormal aortic weight heart disease;hypertension 629621 12775577 Cm12 (maps to same region) 19 1 29550005 5 - by peak with adj size 19 1 29295214 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 19 1 29558305 5 - by peak with adj size 19 1 28982497 5 - by peak with adj size 631679 rat Cm10 Cardiac mass QTL 10 3 7.34 1.0E-4 34186 D3Mgh9 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy;hypertension 629621 12775577 3 1 31148083 5 - by peak with adj size 3 1 26510302 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 3 1 25786001 5 - by peak with adj size 3 1 31158234 5 - by peak with adj size 631680 rat Cm11 Cardiac mass QTL 11 9 3.1 8.9E-4 39812 D9Rat125 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy;hypertension 629621 12775577 9 24567770 69567770 5 - by peak with adj size 9 17330701 62330701 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 9 24885099 69885099 5 - by peak with adj size 9 20430519 65430519 5 - by peak with adj size 631681 rat Cm12 Cardiac mass QTL 12 19 3.33 5.3E-4 35567 D19Rat18 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy Left Ventricular Hypertrophy;hypertension 629621;1600252;2307185 12775577;17143179;18824493 Cm9 (maps to same region) 19 1 29550005 5 - by peak with adj size 19 1 29295214 5 - by peak with adj size SS/JrRkbxSHR/Rkb 631695 631696 SS/JrRkb SHR/FubRkb 19 1 29558305 5 - by peak with adj size 19 1 28982497 5 - by peak with adj size 631682 rat Bp115 Blood pressure QTL 115 2 4.3 1.0E-4 66484 D2Uia17 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629622 12473864 2845;3043;3329;69413 Htr1a;Map1b;Pik3r1;Rasgrf2 additive 2 1 35028452 5 - by peak with adj size 2 1 35849844 5 - by peak with adj size SS/JrxAS 10041 67958 SS/Jr AS 2 1 35167060 5 - by peak with adj size 2 1 37410502 5 - by peak with adj size 631683 rat Bp116 Blood pressure QTL 116 4 1.0E-4 36143 D4Rat60 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629622 12473864 2042;2096;2256;2360;2933;2949;3371;3418;3826;62017;621141 Add2;Alox5;Cald1;Clcn1;Itpr1;Kcna1;Pparg;Prss2;Tbxas1;Pebp1;Wnk1 dominant 4 186408226 231408226 5 - by peak with adj size 4 127060280 172060280 5 - by peak with adj size SS/JrxAS 10041 67958 SS/Jr AS 4 123111827 168111827 5 - by peak with adj size 4 124303370 169303370 5 - by peak with adj size 631684 rat Bp117 Blood pressure QTL 117 1 8.3 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 1 119421009 164421009 3 - by peak only 1 112480604 157480604 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 631685 rat Bp118 Blood pressure QTL 118 3 3.2 37166 D3Rat110 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 3 31324797 76324797 5 - by peak with adj size 3 20229699 65229699 5 - by peak with adj size SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 3 24655225 69655225 5 - by peak with adj size 631686 rat Bp119 Blood pressure QTL 119 5 3.8 11072 D5Mgh2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 629623 12569259 16 39315759 84315759 3 - by peak only 5 1 40017184 3 - by peak only SHRSP/A3IzmxWKY/Izm 631286 631691 WKY/Izm SHRSP/A3Izm 631687 rat Hcas1 Hepatocarcinoma susceptibility QTL 1 7 3.9 0.001 36193 D7Rat3 34555 D7Mgh6 37802 D7Rat78 liver integrity trait (VT:0010547) liver tumorous lesion volume to total liver volume ratio (CMO:0001082) increased hepatocellular carcinoma incidence Experimental Liver Neoplasms 619598 10493520 3130 Myc dominant 7 100740273 143501887 2 - by one flank and peak markers 7 96649133 137404381 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 7 100160423 140335001 1 - by flanking markers 7 91412594 129807172 1 - by flanking markers 631688 rat Hcas2 Hepatocarcinoma susceptibility QTL 2 1 3.0 1.0E-4 43175 D1Mgh16 35166 D1Rat33 34433 D1Mgh3 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) increased hepatocellular carcinoma incidence Experimental Liver Neoplasms 619598 10493520 dominant 1 7306799 123747809 1 - by flanking markers 1 6253946 116153262 1 - by flanking markers BNxF344 10008 61109 BN/SsNHsd F344/NHsd 1 5655769 122614963 1 - by flanking markers 1 5925874 115540829 1 - by flanking markers 631689 rat Scl4 Serum cholesterol level QTL 4 4 1.9 0.008 3753 Spr blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 619667 9633608 4 158994747 203994747 5 - by peak with adj size 4 96867443 141867443 5 - by peak with adj size SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 4 94414208 139414208 5 - by peak with adj size 4 95174120 140174120 5 - by peak with adj size 631690 rat Scl5 Serum cholesterol level QTL 5 1 2.1 33844 D1Mit14 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating triglyceride level Hypercholesterolemia;Hypertriglyceridemia 619667 9633608 1 265492278 290094216 5 - by peak with adj size 1 243502887 267910886 5 - by peak with adj size SHR/MolxBB/OK 61107 61110 BB/OK SHR/Mol 1 258132568 282763074 5 - by peak with adj size 1 236125214 260522016 5 - by peak with adj size 631827 rat Alc4 Alcohol consumption QTL 4 5 3.5 3.0 40718 D5Rat120 39756 D5Rat123 34387 D5Mgh17 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;724636;731212 10979603;12960747;14634485 additive Alc10 (interacts with);Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc9 (interacts with) 5 12694705 23381659 1 - by flanking markers 5 10517466 18944220 2 - by one flank and peak markers Intercross HDA1 x LDA1, HAD2 x LAD2;HAD2xLAD2 631844 631845 Iusm:HAD1 Iusm:LAD1 5 7875611 18592319 1 - by flanking markers 5 8187501 18616199 1 - by flanking markers 631828 rat Alc5 Alcohol consumption QTL 5 10 2.4 2.0 34361 D10Mgh25 41276 D10Rat182 34361 D10Mgh25 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;724636;4890458;731212;7401255 10979603;12960747;20705418;14634485;23596094 2401;61836;1304560;1311614;1359733;1563691 Crebbp;Clcn7;Fahd1;Gnptg;Trap1;Mapk8ip3 additive Alc10 (interacts with);Alc11 (interacts with);Alc12 (maps to same region);Alc13 (interacts with);Alc9 (maps to same region);Foco17 (maps to same region) 10 4040517 17443406 1 - by flanking markers 10 5090008 17515458 1 - by flanking markers Intercross;intercross HAD1xLAD1;HAD2xLAD2 631844 631845 Iusm:HAD1 Iusm:LAD1 10 5217199 17555534 1 - by flanking markers 10 5144027 17245662 1 - by flanking markers 631829 rat Alc6 Alcohol consumption QTL 6 12 4.7 4.0 41626 D12Rat93 34389 D12Mgh10 36490 D12Rat18 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;731212;7401255 10979603;14634485;23596094 additive Alc10 (maps to same region);Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc9 (interacts with);Foco19 (maps to same region);Foco6 (maps to same region) 12 34202298 45143158 1 - by flanking markers 12 29675888 39018219 1 - by flanking markers intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 12 32289782 43305579 1 - by flanking markers 12 28607526 37691617 1 - by flanking markers 631830 rat Alc7 Alcohol consumption QTL 7 16 2.9 33848 D16Mit2 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 631230;724636;731212 10979603;12960747;14634485 additive Alc10 (interacts with);Alc11 (maps to same region);Alc12 (interacts with);Alc13 (maps to same region);Alc9 (interacts with) 16 1 27496499 5 - by peak with adj size 16 1 26804456 5 - by peak with adj size Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 16 1 27556253 5 - by peak with adj size 16 1 26727669 5 - by peak with adj size 631831 rat Alc8 Alcohol consumption QTL 8 3 2.7 33782 D3Mit10 38148 D3Rat82 33782 D3Mit10 consumption behavior trait (VT:0002069) calculated ethanol drink intake rate (CMO:0001615) alcohol preference alcohol use disorder 631229;731212 11958543;14634485 Alc10 (interacts with);Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc9 (interacts with) 3 1 38138699 4 - by one flank marker only 3 1 29749474 4 - by one flank marker only Intercross W 634380 634381 iP/Iusm iNP/Iusm 3 1 32972944 4 - by one flank marker only 3 1 33230976 4 - by one flank marker only 631832 rat Sach1 Saccharin preference QTL 1 3 2.7 0.02 3.3 37010 D3Rat49 36472 D3Rat44 36047 D3Rat46 consumption behavior trait (VT:0002069) calculated saccharin drink intake volume (CMO:0001600) saccharin preference;saccharin preference alcohol use disorder 631229 11958543 3 33340297 50884810 1 - by flanking markers 3 23762471 41420436 1 - by flanking markers Intercross W 634380 634381 iP/Iusm iNP/Iusm 3 28136728 45772990 1 - by flanking markers 3 27494621 44188411 1 - by flanking markers 631833 rat Sach2 Saccharin preference QTL 2 16 4.0 0.01 5.0 34066 D16Mgh1 37054 D16Rat17 34553 D16Mgh6 consumption behavior trait (VT:0002069) calculated saccharin drink intake rate (CMO:0001613) saccharin preference;saccharin preference 631229 11958543 additive 16 45651035 52968648 1 - by flanking markers 16 46137355 53486191 1 - by flanking markers Intercross W 634380 634381 iP/Iusm iNP/Iusm 16 45905097 53253355 1 - by flanking markers 16 43024842 50166018 1 - by flanking markers 631834 rat Sach3 Saccharin preference QTL 3 18 3.9 0.01 3.0 39000 D18Rat61 34975 D18Rat13 39000 D18Rat61 consumption behavior trait (VT:0002069) calculated saccharin drink intake volume (CMO:0001600) saccharin preference;saccharin preference 631229 11958543 recessive 18 60167906 67678102 1 - by flanking markers 18 61571526 66720186 1 - by flanking markers Intercross W 634380 634381 iP/Iusm iNP/Iusm 18 60971508 68524999 1 - by flanking markers 18 58805687 63636873 1 - by flanking markers 631835 rat Scl67 Serum cholesterol level QTL 67 1 4.27 1.16E-5 16.1 40126 D1Rat306 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level;increased total body fat amount Hypercholesterolemia;obesity 619669 11071303 2915 Ins1 Bw115 (interacts with);Bw116 (maps to same region);Niddm45 (interacts with) 1 246467792 290094216 5 - by peak with adj size 1 226083572 267910886 5 - by peak with adj size backcross F344/NHsdxBN/SsNHsd 10008 734526 BN/SsNHsd OLETF/Got 631836 rat Stl31 Serum triglyceride level QTL 31 1 4.64 4.87E-6 16.9 35457 D1Rat90 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia 619669 11071303 2915 Ins1 Bw115 (maps to same region);Bw116 (maps to same region);Niddm45 (interacts with) 1 266637187 290094216 5 - by peak with adj size 1 244611037 267910886 5 - by peak with adj size backcross F344/NHsdxBN/SsNHsd 10008 734526 BN/SsNHsd OLETF/Got 1 259295704 282763074 5 - by peak with adj size 1 237147813 260522016 5 - by peak with adj size 631837 rat Niddm35 Non-insulin dependent diabetes mellitus QTL 35 1 0.01 2470 Cyp2c12 35457 D1Rat90 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) decreased insulin secretion type 2 diabetes mellitus 619677;619688;1599587;2312611;1600083 10580437;11723056;16951059;17130497;19697080 Gluco51 (maps to same region);Insul12 (maps to same region) 1 266156838 289137268 1 - by flanking markers 1 222111153 267111153 4 - by one flank marker only 631294 F344.GK-(D1Arb42a-D1Rat90)/Swe 1 258709726 281795785 1 - by flanking markers 1 238699859 259647894 1 - by flanking markers 631838 rat Niddm36 Non-insulin dependent diabetes mellitus QTL 36 1 0.01 33903 D1Mit7 11148 D1Mgh25 insulin secretion trait (VT:0003564) calculated pancreatic islet insulin release measurement (CMO:0001217) decreased insulin secretion type 2 diabetes mellitus 619677;619688 10580437;11723056 1 257430719 262617194 1 - by flanking markers 1 235677683 240980142 1 - by flanking markers 631847 F344.GK-(D1Mit7-D1Mgh25)/Swe 1 205195290 250195290 4 - by one flank marker only 1 184550676 229550676 4 - by one flank marker only 631839 rat Niddm37 Non-insulin dependent diabetes mellitus QTL 37 14 3.37 33953 D14Mit1 35897 D14Rat22 2670 Gck blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619676 10218444 2670;2872;2874 Gck;Igfbp1;Igfbp3 14 12623297 106705037 1 - by flanking markers 14 12386493 102509397 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 14 12680424 106641756 1 - by flanking markers 14 11030622 95876975 1 - by flanking markers 631840 rat Niddm38 Non-insulin dependent diabetes mellitus QTL 38 19 3.86 36165 D19Rat13 34312 D19Mgh4 11389 D19Mgh2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619676;2313613;7401255 10218444;19575795;23596094 2394;3199;620475 Cpe;Npy5r;Npy2r Bw130 (maps to same region) 19 10733966 37177349 1 - by flanking markers 19 10762811 24725428 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 19 10739929 26201726 1 - by flanking markers 19 10323180 23069265 1 - by flanking markers 631841 rat Niddm39 Non-insulin dependent diabetes mellitus QTL 39 3 3.36 10502 D3Mgh10 33774 D3Mit15 11355 D3Wox8 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619676 10218444 2810;2954 Hnf4a;Kcnb1 3 106065024 174828750 1 - by flanking markers 3 93894678 161985069 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 3 99465522 168732722 1 - by flanking markers 3 94856903 159898684 1 - by flanking markers 631842 rat Inf1 Infertility severity QTL 1 8 4.1 0.001 46.0 3898 Tpm1 seminal gland mass (VT:0010524) seminal vesicle wet weight (CMO:0001603) decreased litter size;reduced male fertility;small seminal vesicle male infertility 631224 10615258 8 32174392 77174392 4 - by one flank marker only 8 26358063 71358063 4 - by one flank marker only SHR/OlaIpcvxBN-Lx/Cub 61117 631848 BN-Lx/Cub SHR/OlaIpcv 8 27841496 72841496 4 - by one flank marker only 8 22662330 67662330 4 - by one flank marker only 631843 rat Bw116 Body weight QTL 116 1 4.1 0.016 37902 D1Rat169 42550 D1Rat459 35457 D1Rat90 abdominal adipose amount (VT:1000220) abdominal fat pad weight (CMO:0000088) increased body weight;increased circulating cholesterol level hyperglycemia;type 2 diabetes mellitus 619679;619678;619669 11355573;10373320;11071303 Bw115 (maps to same region);Scl67 (maps to same region);Stl31 (maps to same region) 1 251652807 289700417 1 - by flanking markers 1 229876870 267593558 1 - by flanking markers backcross OLETFxF344 734527 OLETF.F344-(D1Rat169-D1Rat459)/Got 1 244401175 282365384 1 - by flanking markers 1 224054293 260122809 1 - by flanking markers 634305 rat Mamtr1 Mammary tumor resistance QTL 1 5 1.0E-4 69542 D5Uwm8 35306 D5Rat26 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 631852;631853 12844486;12783625 dominant 5 17423817 121495774 1 - by flanking markers 5 12880403 119333229 1 - by flanking markers 634359 WF.WKY-(D5Pas1-D5Uwm37)/Uwm 5 12651967 117554267 1 - by flanking markers 5 12789751 113558310 1 - by flanking markers 634306 rat Bp140 Blood pressure QTL 140 3 3.3 0.0013 35609 D3Rat53 38552 D3Rat80 71061 Kynu arterial blood pressure trait (VT:2000000) body weight (CMO:0000012);diastolic blood pressure (CMO:0000005);heart rate (CMO:0000002);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631322 11924719 71061 Kynu 3 18456092 41714034 1 - by flanking markers 3 16185366 32056774 2 - by one flank and peak markers intercross SHR/HosxWKY/Hos 631603 631604 WKY/Snk SHR/Snk 3 13126914 36600143 1 - by flanking markers 3 17374703 35528639 1 - by flanking markers 634307 rat Bp141 Blood pressure QTL 141 6 4.0 33977 D6Mit4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631324;1358767 10523818;15685431 Stresp10 (maps to same region) 6 47694055 92694055 5 - by peak with adj size 6 37446751 82446751 5 - by peak with adj size intercross LEW/NIcoxSHR/NIco 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 6 38106308 83106308 5 - by peak with adj size 6 35230417 80230417 5 - by peak with adj size 634308 rat Sach6 Saccharin preference QTL 6 2 4.9 31.5 38626 D2Rat171 67315 D2Arb24 36093 D2Rat26 taste sensitivity trait (VT:0001986) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) abnormal conditioned taste aversion behavior 631221 11958542 2 135770850 248088631 1 - by flanking markers 2 116874922 221284686 1 - by flanking markers intercross HXBxBXH 61098 61099 BXH/Ipcv HXB/Ipcv 2 116075644 228737869 1 - by flanking markers 2 112456140 212696837 1 - by flanking markers 634310 rat Bp142 Blood pressure QTL 142 12 4.2 33776 D12Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631324 10523818 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 634311 rat Sach7 Saccharin preference QTL 7 4 38.5 33757 D4Mit2 11468112 Hoxa2 taste sensitivity trait (VT:0001986) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) abnormal conditioned taste aversion behavior 631221 11958542 4 55539015 100539015 4 - by one flank marker only 4 55369931 100369931 4 - by one flank marker only intercross HXBxBXH 61098 61099 BXH/Ipcv HXB/Ipcv 4 55791564 82134846 1 - by flanking markers 4 57114432 81266970 1 - by flanking markers 634312 rat Bp143 Blood pressure QTL 143 1 3.0 2.0E-4 12.0 38326 D1Rat129 41036 D1Rat298 37184 D1Rat188 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631325 11984003 1 218337839 247303260 1 - by flanking markers 1 198853034 225625256 1 - by flanking markers intercross SS/HsdxSR/Hsd 634365 634366 SS/Hsd SR/Hsd 1 198446729 240017341 2 - by one flank and peak markers 1 182623426 219932796 2 - by one flank and peak markers 634313 rat Niddm43 Non-insulin dependent diabetes mellitus QTL 43 1 34244 D1Mgh10 35457 D1Rat90 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating insulin level;impaired glucose tolerance glucose intolerance 619677;619688 10580437;11723056 Niddm44 (interacts with) 1 223910550 289137268 1 - by flanking markers 1 204280278 267111153 1 - by flanking markers 631846 F344.GK-(D1Mgh10-D1Rat90)/Swe 1 217054291 281795785 1 - by flanking markers 1 199050459 259647894 1 - by flanking markers 634314 rat Niddm44 Non-insulin dependent diabetes mellitus QTL 44 1 34244 D1Mgh10 35891 D1Rat19 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating insulin level;impaired glucose tolerance glucose intolerance 619677;619688;2312611 10580437;11723056;19697080 Gluco51 (maps to same region);Niddm43 (interacts with) 1 50173266 223910550 1 - by flanking markers 1 43872827 204280278 1 - by flanking markers 634370 F344.GK-(D1Mgh10-D1Rat119)/Swe 1 49578693 217054291 1 - by flanking markers 1 49393289 199050459 1 - by flanking markers 634315 rat Niddm45 Non-insulin dependent diabetes mellitus QTL 45 1 7.16 34399 D1Mgh9 33959 D1Mit3 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) abnormal percent body fat/body weight;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619678;2312611;619669 10373320;19697080;11071303 Bw85 (maps to same region);Scl67 (interacts with);Stl31 (interacts with) 1 162692800 195235368 1 - by flanking markers 1 146971983 176854992 1 - by flanking markers backcross OLETFxBN 60985 61014 BN OLETF 1 156446783 188289244 1 - by flanking markers 1 144267916 172949660 1 - by flanking markers 634317 rat Bw117 Body weight QTL 117 3 3.58 34336 D3Mgh7 36456 D3Rat41 abdominal fat pad mass (VT:1000711) abdominal fat pad weight to body weight ratio (CMO:0000095) increased total body fat amount obesity 619678;2313613;2298688 10373320;19575795;18612083 Bw82 (maps to same region) 3 45609749 61363738 1 - by flanking markers 3 36556706 50635971 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 3 40523593 54745780 1 - by flanking markers 3 39454637 53296578 1 - by flanking markers 634318 rat Bw118 Body weight QTL 118 6 3.55 33977 D6Mit4 33828 D6Mit9 abdominal fat pad mass (VT:1000711) abdominal fat pad weight (CMO:0000088) decreased body weight;decreased circulating glucose level;decreased total body fat amount obesity 619678 10373320 6 46021394 70193933 1 - by flanking markers 6 34039461 59946628 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 6 36260288 60606186 1 - by flanking markers 6 33309549 57730294 1 - by flanking markers 634319 rat Bw119 Body weight QTL 119 7 5.44 36715 D7Rat30 36715 D7Rat30 36715 D7Rat30 abdominal fat pad mass (VT:1000711) abdominal fat pad weight to body weight ratio (CMO:0000095) decreased total body fat amount;impaired glucose tolerance obesity;type 2 diabetes mellitus 619678 10373320 7 34212196 34212335 1 - by flanking markers 7 30339292 30339432 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 7 34147033 34147172 1 - by flanking markers 7 27828949 27829089 1 - by flanking markers 634320 rat Niddm49 Non-insulin dependent diabetes mellitus QTL 49 10 4.41 11169 D10Mgh21 33941 D10Mit11 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) decreased circulating glucose level type 2 diabetes mellitus 619678 10373320 10 91455889 112200500 4 - by one flank marker only 10 92782172 101848683 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 10 91689348 112626471 4 - by one flank marker only 10 88539139 107211142 4 - by one flank marker only 634321 rat Hc1 Hypercalciuria QTL 1 1 2.91 7.0 39006 D1Rat193 38078 D1Rat142 37902 D1Rat169 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 1 201022827 268717248 1 - by flanking markers 1 183163129 248833756 1 - by flanking markers intercross SD/GHSxWKY 61103 634372 WKY GHS 1 193968438 261264776 1 - by flanking markers 1 178810256 240830002 1 - by flanking markers 634322 rat Bw12 Body weight QTL 12 7 0.0 37808 D7Rat86 38402 D7Rat102 38402 D7Rat102 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 619682 11414764 7 96743589 141743589 5 - by peak with adj size 7 88132195 115934193 1 - by flanking markers intercross BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc 6 10173862 55173862 4 - by one flank marker only 7 83153392 128153392 4 - by one flank marker only 634323 rat Hc2 Hypercalciuria QTL 2 4 2.15 39704 D4Rat222 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 4 1 42064565 5 - by peak with adj size 4 1 41544239 5 - by peak with adj size intercross SD/GHSxWKY 61103 634372 WKY GHS 4 1 42118977 5 - by peak with adj size 4 210796 45210796 5 - by peak with adj size 634325 rat Bw13 Body weight QTL 13 X 0.0 35030 DXRat2 36111 DXRat8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight;increased circulating insulin level;pancreas inflammation hyperinsulinism;pancreatitis 619682 11414764 X 2456432 21859240 1 - by flanking markers X 1 41387080 4 - by one flank marker only intercross BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc X 1662453 21592783 1 - by flanking markers X 1447972 20991088 1 - by flanking markers 634326 rat Hc3 Hypercalciuria QTL 3 7 2.1 40164 D7Rat164 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 7 50418802 95418802 5 - by peak with adj size 7 47007003 92007003 5 - by peak with adj size intercross SD/GHSxWKY 61103 634372 WKY GHS 7 50252103 95252103 5 - by peak with adj size 7 42787314 87787314 5 - by peak with adj size 634327 rat Hc4 Hypercalciuria QTL 4 10 2.4 35769 D10Rat47 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 10 1 38488522 5 - by peak with adj size 10 1 38576664 5 - by peak with adj size intercross SD/GHSxWKY 61103 634372 WKY GHS 10 1 38594330 5 - by peak with adj size 10 1 38328221 5 - by peak with adj size 634328 rat Hc5 Hypercalciuria QTL 5 14 2.3 11086 D14Mgh1 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level Kidney Calculi 631855 12819244 14 64239904 109239904 5 - by peak with adj size 14 63969145 108969145 5 - by peak with adj size 61103 634372 WKY GHS 14 63548095 108548095 5 - by peak with adj size 14 58184885 103184885 5 - by peak with adj size 634329 rat Pia15 Pristane induced arthritis QTL 15 10 3.1 36319 D10Rat26 36522 D10Rat44 34318 D10Mgh10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198;2296064 12817024;18606636;16804090;18540828;18453595 dominant Eau7 (maps to same region) 10 24738710 47171288 2 - by one flank and peak markers 10 24731630 47777990 2 - by one flank and peak markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 10 24884084 47487910 2 - by one flank and peak markers 10 1 24158324 4 - by one flank marker only 634330 rat Pia16 Pristane induced arthritis QTL 16 6 3.9 34072 D6Mgh7 34108 D6Mgh10 35102 D6Rat16 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198 12817024;18606636;16804090;18540828 dominant 6 57131392 117277618 1 - by flanking markers 6 47039212 108621490 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 6 48432758 108268790 1 - by flanking markers 6 45790088 104200226 1 - by flanking markers 634331 rat Pia17 Pristane induced arthritis QTL 17 7 4.7 11165 D7Mit9 37144 D7Rat74 33670 D7Mit2 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198 12817024;18606636;16804090;18540828 dominant 7 81663683 143501887 2 - by one flank and peak markers 7 78497123 137838800 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 7 81645773 140745067 1 - by flanking markers 7 73829340 130221005 1 - by flanking markers 634332 rat Pia18 Pristane induced arthritis QTL 18 8 4.0 35905 D8Rat21 35248 D8Rat26 34068 D8Mgh11 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2300074;1582387;2307198 12817024;18606636;16804090;18540828 dominant 8 81033305 89073299 1 - by flanking markers 8 79347688 87122814 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 8 81414058 89542815 1 - by flanking markers 8 75311938 82925521 1 - by flanking markers 634333 rat Pia19 Pristane induced arthritis QTL 19 18 3.4 35282 D18Rat5 33715 D18Mit6 33715 D18Mit6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2307198;2300074;1582387 12817024;18540828;18606636;16804090 dominant 18 76260634 82427750 1 - by flanking markers 18 77452390 82920522 1 - by flanking markers backcross DA/RhdxE3/Rhd 634373 634374 DA/ZtmRhd E3/ZtmRhd 18 77151301 83366399 1 - by flanking markers 18 73997140 79532029 1 - by flanking markers 634334 rat Xhs3 X-ray hypersensitivity QTL 3 4 10.0 42306 D4Rat266 35262 D4Rat79 36043 D4Rat49 intestine integrity trait (VT:0010554) post-insult time to onset of moribundity (CMO:0001896) increased cellular sensitivity to X-ray irradiation Experimental Radiation Injuries 631318 11381618 recessive 4 150446360 194116548 1 - by flanking markers 4 84355208 131969855 1 - by flanking markers intercross LEA/NcuxBN/Sea 634376 634377 LEA/Ncu BN/Sea 4 85794049 129615056 1 - by flanking markers 4 84728680 129854654 1 - by flanking markers 634335 rat Anxrr16 Anxiety related response QTL 16 4 7.22 50.4 34338 D4Mgh11 35286 D4Rat37 34106 D4Mgh6 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 631324;1598975;1598390;6218999 10523818;17052845;16923148;21516450 3811 Tacr1 dominant 4 159682169 230565073 1 - by flanking markers 4 93498821 171204377 1 - by flanking markers intercross LEW/NIcoxSHR/NIco 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 4 94893247 168046938 1 - by flanking markers 11528588 SHR.LEW-(D4Rat76-D4Mgh11)/Anra 4 93308457 167139447 1 - by flanking markers 634336 rat Anxrr17 Anxiety related response QTL 17 7 3.66 39648 D7Rat127 34039 D3Mit11 34164 D7Mgh11 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased anxiety-related response anxiety disorder 631324;1598975;1598390 10523818;17052845;16923148 additive 7 2893487 124826707 1 - by flanking markers 7 1786555 121975577 1 - by flanking markers intercross LEW/NIcoxSHR/NIco 634363 634364 LEW/NIcoCrlf SHR/NIcoCrlf 7 2920071 124838025 1 - by flanking markers 7 924703 115097879 1 - by flanking markers 634338 rat Hcar4 Hepatocarcinoma resistance QTL 4 1 4.6 34021 D1Mit28 43424 D1Wox10 34244 D1Mgh10 liver integrity trait (VT:0010547) liver tumorous lesion number to liver area ratio (CMO:0001210) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 2315;2758;2775;2827;2829;2870;2916 Cd81;Gstp1;H19;Hras;Plaat3;Igf2;Ins2 recessive 1 217888119 244066407 1 - by flanking markers 1 198396580 220639653 1 - by flanking markers intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 1 210960636 236763528 1 - by flanking markers 1 193422268 214537671 1 - by flanking markers 634339 rat Niddm50 Non-insulin dependent diabetes mellitus QTL 50 11 3.32 34725 D11Mgh3 34150 D11Mgh5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) abnormal percent body fat/body weight;increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 619678;61072 10373320;9585427 11 47637447 72739687 1 - by flanking markers 11 43157054 68234781 1 - by flanking markers intercross OLETFxBN 60985 61014 BN OLETF 11 44444347 69649708 1 - by flanking markers 11 66422148 86241447 4 - by one flank marker only 634340 rat Hcar5 Hepatocarcinoma resistance QTL 5 1 8.0 43424 D1Wox10 41392 D1Rat302 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 2456;2469 Cyp17a1;Cyp2c11 recessive 1 244066294 254305341 1 - by flanking markers 1 220639539 232579992 1 - by flanking markers intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 1 236763415 247065599 1 - by flanking markers 1 214537555 226660468 1 - by flanking markers 634341 rat Bw121 Body weight QTL 121 11 3.56 34150 D11Mgh5 33899 D11Mit4 abdominal fat pad mass (VT:1000711) abdominal fat pad weight (CMO:0000088) increased body weight;increased total body fat amount obesity 619678 10373320 11 25682771 47637212 1 - by flanking markers 11 22214205 43156819 1 - by flanking markers backcross OLETFxBN 60985 61014 BN OLETF 11 22043149 44444112 1 - by flanking markers 11 1 21836709 4 - by one flank marker only 634342 rat Cia24 Collagen induced arthritis QTL 24 4 4.5 7.6 33995 D4Mit19 10752 D4Wox12 11163 D4Arb2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 61066;2307198;2300074;1582387;619594 10857786;18540828;18606636;16804090;11486281 2306;61318;61319;621237 Cd4;Cd69;Tnfrsf7;Tnfrsf1a additive 4 208670980 240723450 1 - by flanking markers 4 149304432 179854843 1 - by flanking markers intercross DA/BklxBN/SsN 61114 61115 DA/Bkl BN/SsN 4 145373934 176509907 1 - by flanking markers 4 146565735 175236377 1 - by flanking markers 634343 rat Hcar6 Hepatocarcinoma resistance QTL 6 1 10674 D1Mgh12 liver integrity trait (VT:0010547) area of individual liver tumorous lesion (CMO:0001071) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609 10850431 recessive 1 248216971 290094216 5 - by peak with adj size 1 224822211 267910886 5 - by peak with adj size intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 634344 rat Hcar7 Hepatocarcinoma resistance QTL 7 4 7.8 35811 D4Rat23 35286 D4Rat37 35286 D4Rat37 liver integrity trait (VT:0010547) liver tumorous lesion area to total liver area ratio (CMO:0001075);liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 2688 Ghrhr semidominant 4 58518376 159682169 1 - by flanking markers 4 58550170 93498821 1 - by flanking markers intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 4 71476518 116476518 5 - by peak with adj size 4 70808386 115808386 5 - by peak with adj size 634346 rat Insul4 Insulin level QTL 4 X 0.0 12.0 39724 DXRat103 60694 DXGot62 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level;increased heart weight;pancreas inflammation hyperinsulinism;pancreatitis 619682 11414764 additive X 134700617 154597545 4 - by one flank marker only X 134157190 160699376 4 - by one flank marker only intercross BN/CrjxWBN/KobSlc 634367 634369 BN/CrlCrlj WBN/KobSlc X 134627816 159970021 4 - by one flank marker only X 126975089 152453651 4 - by one flank marker only 634347 rat Hcar8 Hepatocarcinoma resistance QTL 8 4 5.8 36508 D4Rat48 liver integrity trait (VT:0010547) liver tumorous lesion area to total liver area ratio (CMO:0001075) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 619609;625382 10850431;11756240 3849 Tgfa semidominant 4 187067577 232067577 4 - by one flank marker only intercross DRHxF344 70509 625659 F344/NRrrc DRH/Seac 4 123478354 168478354 4 - by one flank marker only 4 123143783 168143783 4 - by one flank marker only 634348 rat Bp138 Blood pressure QTL 138 1 37428 D1Rat200 2254 Calca 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631321 12358148 2156;2254;3214;621323 Arrb1;Calca;Ntrk3;Phox2a 1 134116233 191162954 1 - by flanking markers 1 126938969 172691061 1 - by flanking markers intercross SHRSP/IzmxWKY/Izm 631286 631599 WKY/Izm SHRSP/Izm 1 133076978 184188922 1 - by flanking markers 1 125611501 168883176 1 - by flanking markers 634349 rat Bp139 Blood pressure QTL 139 5 0.001 10454 D5Wox12 43937 D5Wox20 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 631851 12790759 5 137990322 177180328 4 - by one flank marker only 5 135877124 173096209 4 - by one flank marker only 634382 SHR.BN-(D5Wox12-D5Wox20)/Ipcv 5 134197905 173707219 4 - by one flank marker only 5 128924607 166875058 4 - by one flank marker only 634350 rat Apr4 Acute phase response QTL 4 12 6.0 35889 D12Rat10 orosomucoid 1 amount (VT:0010541) plasma orosomucoid 1 level (CMO:0001467) abnormal acute phase protein level rheumatoid arthritis 629561 11817600 recessive 12 6200431 51200431 5 - by peak with adj size 12 2248421 46782294 5 - by peak with adj size intercross E3xDA 60997 61013 DA E3 12 4210051 49210051 5 - by peak with adj size 12 1172005 46172005 5 - by peak with adj size 634351 rat Apr5 Acute phase response QTL 5 12 6.7 11449 D12Wox14 blood interleukin-6 amount (VT:0008595) plasma interleukin-6 level (CMO:0001927) abnormal circulating interleukin-6 level rheumatoid arthritis 629561 11817600 recessive 12 4514063 49514063 5 - by peak with adj size 12 568621 45568621 5 - by peak with adj size intercross E3xDA 60997 61013 DA E3 12 2513442 47513442 5 - by peak with adj size 12 1 44503507 5 - by peak with adj size 634352 rat Apr6 Acute phase response QTL 6 14 3.7 10622 D14Mgh3 blood interleukin-6 amount (VT:0008595) plasma interleukin-6 level (CMO:0001927) abnormal circulating interleukin-6 level rheumatoid arthritis 629561 11817600 recessive 14 1 42672729 5 - by peak with adj size 14 1 42665455 5 - by peak with adj size intercross E3xDA 60997 61013 DA E3 14 1 42766285 5 - by peak with adj size 14 1 41131407 5 - by peak with adj size 634353 rat Rends2 Renal damage susceptibility QTL 2 1 0.05 36303 D1Rat6 37962 D1Rat201 38568 D1Rat238 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) abnormal kidney vasculature morphology end stage renal disease 631854 12874092 1 21827911 58931238 1 - by flanking markers 1 19793567 54719627 1 - by flanking markers intercross SHRSPxSHR 61000 61010 SHR SHRSP 1 20341560 58000154 1 - by flanking markers 1 19333571 56983283 1 - by flanking markers 634354 rat Rends3 Renal damage susceptibility QTL 3 10 0.05 35563 D10Rat21 34939 D10Rat55 2875 Igfbp4 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) abnormal kidney vasculature morphology end stage renal disease 631854 12874092 10 82495432 87933580 1 - by flanking markers 10 83527877 89167279 1 - by flanking markers SHRSPxSHR 61000 61010 SHR SHRSP 10 82675233 88141097 1 - by flanking markers 10 79813789 85160854 1 - by flanking markers 634355 rat Rends4 Renal damage susceptibility QTL 4 16 0.05 33848 D16Mit2 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) abnormal kidney vasculature morphology end stage renal disease 631854 12874092 16 1 27496499 5 - by peak with adj size 16 1 26804456 5 - by peak with adj size intercross SHRSPxSHR 61000 61010 SHR SHRSP 16 1 27556253 5 - by peak with adj size 16 1 26727669 5 - by peak with adj size 724513 rat Uae14 Urinary albumin excretion QTL 14 6 6.5 36191 D6Rat6 37280 D6Rat104 36990 D6Rat12 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 6 98478049 132488388 1 - by flanking markers 6 88723578 123455031 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 6 88996335 139410483 2 - by one flank and peak markers 6 85311061 133478515 2 - by one flank and peak markers 724514 rat Uae15 Urinary albumin excretion QTL 15 8 2.9 40746 D8Rat162 35987 D8Rat30 36117 D8Rat46 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 8 32227585 80296943 1 - by flanking markers 8 30878636 74178909 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 8 32201981 75971421 1 - by flanking markers 8 29502665 70386295 1 - by flanking markers 724515 rat Uae16 Urinary albumin excretion QTL 16 9 8.0 8.0 36027 D9Rat3 34013 D9Mit3 35691 D9Rat5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 9 63077544 107462655 1 - by flanking markers 9 55476135 99799760 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 9 63270073 107878387 1 - by flanking markers 9 58163035 100929646 1 - by flanking markers 724516 rat Uae17 Urinary albumin excretion QTL 17 10 3.6 41534 D10Rat143 37460 D10Rat93 35108 D10Rat30 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 10 80788180 87993909 1 - by flanking markers 10 81887390 89227496 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 10 80946110 88200662 1 - by flanking markers 10 78210622 85220348 1 - by flanking markers 724517 rat Uae18 Urinary albumin excretion QTL 18 11 3.7 35565 D11Rat20 36065 D11Rat6 33792 D11Mit2 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 11 19976405 49765656 1 - by flanking markers 11 16670176 45232986 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 11 16321973 46583360 1 - by flanking markers 11 16472047 44285911 1 - by flanking markers 724518 rat Uae19 Urinary albumin excretion QTL 19 19 5.5 33618 D19Mit7 37042 D19Rat19 35881 D19Rat11 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633 12799471 19 8062244 58132164 1 - by flanking markers 19 7813671 45090802 1 - by flanking markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 19 8072545 47318201 1 - by flanking markers 19 7457249 42983518 1 - by flanking markers 724519 rat Bp144 Blood pressure QTL 144 20 0.001 61303 D20Utr1 3876 Tnf 61303 D20Utr1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 619638 8938440 20 1 6938847 4 - by one flank marker only 20 1 3663618 4 - by one flank marker only intercross 61098 BXH/Ipcv 20 1 5192000 4 - by one flank marker only 20 1 3624629 4 - by one flank marker only 724520 rat Bp145 Blood pressure QTL 145 1 2.1 0.0024 38782 D1Rat136 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 634618 12397040 1 22407702 67407702 5 - by peak with adj size 1 15147212 60147212 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 1 21079305 66079305 5 - by peak with adj size 1 20784828 65784828 5 - by peak with adj size 724521 rat Uae1 Urinary albumin excretion QTL 1 1 3.8 1.0E-4 36765 D1Rat27 39314 D1Rat216 36023 D1Rat38 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 1 95301716 205161264 1 - by flanking markers 1 90282040 185923619 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 1 94201400 184846632 2 - by one flank and peak markers 1 90508614 173018436 2 - by one flank and peak markers 724522 rat Bp146 Blood pressure QTL 146 4 2.2 0.0021 35325 D4Rat41 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 634618 12397040 4 140044845 185044845 5 - by peak with adj size 4 74123346 119123346 5 - by peak with adj size 724569 724570 MWF/FubRkb LEW/Rkb 4 75258970 120258970 5 - by peak with adj size 4 73630210 118630210 5 - by peak with adj size 724523 rat Tsu1 Thymus enlargement suppressive QTL 1 3 3.84 33668 D3Mit13 3632 Scn2a 2279 Cat thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) small thymus Thymus Hyperplasia 634729 9234381 3 58456658 129091156 1 - by flanking markers 3 47722800 115996144 1 - by flanking markers backcross BUF/MnaxMITE/Mna 61118 724571 BUF/Mna MITE/Mna 3 51822008 120917851 1 - by flanking markers 3 50437504 115638231 1 - by flanking markers 724524 rat Uae2 Urinary albumin excretion QTL 2 6 2.7 5.0E-4 36990 D6Rat12 34306 D6Mgh5 38246 D6Rat71 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 6 86432188 123469988 1 - by flanking markers 6 76380261 114031923 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 6 76902247 114203334 1 - by flanking markers 6 73463459 109394713 1 - by flanking markers 724525 rat Bp147 Blood pressure QTL 147 5 4.3 1.0E-4 35825 D5Rat41 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 634618 12397040 5 136316651 177180328 5 - by peak with adj size 5 132950669 173096209 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 5 132551937 173707219 5 - by peak with adj size 5 126424772 166875058 5 - by peak with adj size 724526 rat Uae3 Urinary albumin excretion QTL 3 12 4.9 1.0E-4 39744 D12Rat59 38052 D12Rat37 36538 D12Rat7 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 12 7519792 14407498 1 - by flanking markers 12 155313 10701201 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 12 5406094 12355490 1 - by flanking markers 12 3906969 10373166 1 - by flanking markers 724527 rat Bp148 Blood pressure QTL 148 10 1.0E-4 631289 D10M11Mit119 36203 D10Rat27 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 704345 12939233 10 29127968 74127968 4 - by one flank marker only 10 32092169 77092169 4 - by one flank marker only 12902614 SS.LEW-(D10M11Mit119-D10Rat27)/Ayd 10 30983805 75983805 4 - by one flank marker only 10 28453136 73453136 4 - by one flank marker only 724528 rat Uae4 Urinary albumin excretion QTL 4 17 4.9 1.0E-4 36011 D17Rat17 35473 D17Rat58 40276 D17Rat133 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level cardiovascular system disease;proteinuria 634618 12397040 17 39651255 75089871 1 - by flanking markers 17 42344830 81039660 1 - by flanking markers intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 17 37790306 73413148 1 - by flanking markers 17 35837085 69599340 1 - by flanking markers 724529 rat Cm16 Cardiac mass QTL 16 1 2.7 38420 D1Rat189 37168 D1Rat158 36007 D1Rat36 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight;increased systemic arterial blood pressure heart disease;hypertension 634617 12707388 1 91941720 167535765 1 - by flanking markers 1 87465281 153578547 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 1 90804143 161321256 1 - by flanking markers 1 87580395 150700247 1 - by flanking markers 724530 rat Bp149 Blood pressure QTL 149 10 1.0E-4 34896 D10Rat17 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 704345 12939233 10 93641751 112200500 4 - by one flank marker only 10 95066219 99588446 1 - by flanking markers 724575 SS.LEW-(D10Rat17-D10Mgh1)/Ayd 10 93886117 112626471 4 - by one flank marker only 10 90627439 107211142 4 - by one flank marker only 724531 rat Uae5 Urinary albumin excretion QTL 5 1 4.0 37168 D1Rat158 36703 D1Rat86 66610 D1Mco35 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 1 167535661 281205280 1 - by flanking markers 1 153578442 259173490 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 1 161321152 273792054 1 - by flanking markers 1 150700142 252085212 1 - by flanking markers 724532 rat Cm17 Cardiac mass QTL 17 3 2.0 41442 D3Rat160 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 3 107558308 152558308 5 - by peak with adj size 3 96192217 141192217 5 - by peak with adj size intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 3 101058963 146058963 5 - by peak with adj size 3 95735366 140735366 5 - by peak with adj size 724533 rat Rf51 Renal function QTL 51 1 5.3 2.0E-4 34194 D1Mgh14 33945 D1Mit18 33903 D1Mit7 kidney plasma flow trait (VT:0005524) renal plasma flow (CMO:0001914) decreased renal glomerular filtration rate;decreased renal plasma flow rate;increased renal vascular resistance kidney disease 619628 10545438 codominant 1 246119106 285604773 1 - by flanking markers 1 224426393 263698966 1 - by flanking markers intercross SHRxWKY 61000 61103 SHR WKY 1 238830534 278228767 1 - by flanking markers 1 218753816 256448513 1 - by flanking markers 724534 rat Uae6 Urinary albumin excretion QTL 6 2 10.0 66661 D2Mco18 35915 D2Rat61 36773 D2Rat50 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;glomerulosclerosis;increased urine protein level Albuminuria;focal segmental glomerulosclerosis;proteinuria 634617 12707388 2 88595515 100298396 1 - by flanking markers 2 79796833 227150249 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 2 68866454 80631953 1 - by flanking markers 2 78665619 249053267 2 - by one flank and peak markers 724535 rat Cm18 Cardiac mass QTL 18 4 2.6 40642 D4Rat195 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 4 182393351 227393351 5 - by peak with adj size 4 121375269 166375269 5 - by peak with adj size intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 4 117926139 162926139 5 - by peak with adj size 4 118856416 163856416 5 - by peak with adj size 724536 rat Uae7 Urinary albumin excretion QTL 7 6 3.5 11241 D6Mit3 10361 D6Wox13 66623 D6Uia5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 6 85163175 144273990 1 - by flanking markers 6 75049527 136452267 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 6 75623277 136143011 1 - by flanking markers 6 72202632 130729475 1 - by flanking markers 724537 rat Niddm52 Non-insulin dependent diabetes mellitus QTL 52 7 0.02 33648 D7Mit5 10939 D7Mit27 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 7 88393619 103159589 1 - by flanking markers 7 85089895 98955278 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 7 88365265 102588450 1 - by flanking markers 7 80221299 93595843 1 - by flanking markers 724538 rat Kidm1 Kidney mass QTL 1 1 3.2 62481 D1Uia5 36703 D1Rat86 36703 D1Rat86 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) decreased circulating free fatty acids level kidney disease 634617 12707388 1 240777376 281205280 1 - by flanking markers 1 219804771 259173490 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 1 233663100 273792054 1 - by flanking markers 1 213707201 252085212 1 - by flanking markers 724539 rat Cm19 Cardiac mass QTL 19 8 2.6 41310 D8Rat130 35435 D8Rat3 37892 D8Rat90 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 8 100888495 129152962 1 - by flanking markers 8 98986085 126316942 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 8 107769005 129956433 2 - by one flank and peak markers 8 100149864 120994388 2 - by one flank and peak markers 724540 rat Uae8 Urinary albumin excretion QTL 8 8 5.0 33559 D8Mit5 41310 D8Rat130 40746 D8Rat162 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 8 33603024 100888674 1 - by flanking markers 8 32203394 98986263 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 8 30845450 33558764 2 - by one flank and peak markers 8 28157323 30848259 2 - by one flank and peak markers 724541 rat Niddm53 Non-insulin dependent diabetes mellitus QTL 53 14 0.001 36536 D14Rat1 37030 D14Rat3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 14 4830815 10676655 1 - by flanking markers 14 4895894 10340377 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 14 4833233 10729268 1 - by flanking markers 14 3813074 9088978 1 - by flanking markers 724542 rat Kidm2 Kidney mass QTL 2 18 2.6 38862 D18Rat69 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) decreased circulating free fatty acids level kidney disease 634617 12707388 18 62060256 87229863 5 - by peak with adj size 18 62739615 87265094 5 - by peak with adj size intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 18 63009812 88201929 5 - by peak with adj size 18 59172115 83828827 5 - by peak with adj size 724543 rat Cm20 Cardiac mass QTL 20 9 3.9 35871 D9Rat36 35819 D9Rat26 37416 D9Rat70 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 9 18398986 44725204 1 - by flanking markers 9 12625041 37313370 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 9 19520489 45029794 1 - by flanking markers 9 16961398 40594091 1 - by flanking markers 724544 rat Uae9 Urinary albumin excretion QTL 9 9 4.5 37416 D9Rat70 66431 D9Mco6 61287 D9Uia6 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria Albuminuria 634617 12707388 9 27914255 121549591 2 - by one flank and peak markers 9 21667066 105580061 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 9 29075079 122095297 2 - by one flank and peak markers 9 25268044 114175309 2 - by one flank and peak markers 724545 rat Niddm54 Non-insulin dependent diabetes mellitus QTL 54 15 0.02 35362 D15Rat19 35230 D15Rat22 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 15 61238603 84802960 1 - by flanking markers 15 56346569 80370658 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 15 57528970 81263988 1 - by flanking markers 15 50794494 73699215 1 - by flanking markers 724546 rat Kidm3 Kidney mass QTL 3 19 3.1 39018 D19Rat29 66451 D19Uia1 66451 D19Uia1 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) decreased circulating free fatty acids level kidney disease 634617 12707388 19 43887287 72914587 4 - by one flank marker only 19 31224173 59218465 4 - by one flank marker only intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 19 32994392 62275575 4 - by one flank marker only 19 29322490 57337602 4 - by one flank marker only 724547 rat Cm21 Cardiac mass QTL 21 9 2.7 61287 D9Uia6 66431 D9Mco6 38270 D9Rat97 heart mass (VT:0007028) calculated heart weight (CMO:0000073) increased heart weight heart disease 634617 12707388 9 83451810 111224462 2 - by one flank and peak markers 9 77170797 105580061 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 9 83686153 111609081 2 - by one flank and peak markers 9 79271511 102910209 2 - by one flank and peak markers 724548 rat Niddm55 Non-insulin dependent diabetes mellitus QTL 55 15 0.02 35230 D15Rat22 36663 D15Rat21 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 15 79317715 84802815 1 - by flanking markers 15 74779895 80370512 1 - by flanking markers intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 15 75761216 81263843 1 - by flanking markers 15 68327360 73699069 1 - by flanking markers 724549 rat Niddm56 Non-insulin dependent diabetes mellitus QTL 56 17 0.03 33882 D17Mit2 34369 D17Mgh4 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) impaired glucose tolerance glucose intolerance 619670 11381614 17 35195242 80195242 4 - by one flank marker only 17 38353858 83353858 4 - by one flank marker only intercross OLETF/OtkxF344/Crj 69643 734526 F344/DuCrlCrlj OLETF/Got 17 33303627 78303627 4 - by one flank marker only 17 31990784 76990784 4 - by one flank marker only 724550 rat Thym3 Thymus enlargement QTL 3 1 7.82 0.001 33571 D1Mit6 10952 D1Wox21 38210 D1Rat197 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) enlarged thymus Thymus Hyperplasia 70859 10792781 Thym1 (interacts with) 1 160649707 205649707 4 - by one flank marker only 1 141471946 186471946 4 - by one flank marker only backcross BUF/MnaxMITE/Mna 61118 724571 BUF/Mna MITE/Mna 1 153655976 198655976 4 - by one flank marker only 1 136829932 181829932 4 - by one flank marker only 724551 rat Glom1 Glomerulus QTL 1 X 2.8 4.0E-4 39966 DXRat96 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 634618 12397040 X 82820145 127820145 5 - by peak with adj size X 99569771 144569771 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb X 82930791 127930791 5 - by peak with adj size X 75294106 120294106 5 - by peak with adj size 724552 rat Glom2 Glomerulus QTL 2 1 3.3 1.0E-4 37506 D1Rat151 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) abnormal renal glomerulus morphology Albuminuria;proteinuria 634618 12397040 1 250702278 290094216 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 1 243272341 282763074 5 - by peak with adj size 1 222363780 260522016 5 - by peak with adj size 724553 rat Glom3 Glomerulus QTL 3 13 2.9 4.0E-4 39348 D13Rat62 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) abnormal renal glomerulus morphology Albuminuria;proteinuria 634618 12397040 13 46101962 91101962 5 - by peak with adj size 13 38179982 83179982 5 - by peak with adj size intercross MWF/RkbxLEW/Rkb 724569 724570 MWF/FubRkb LEW/Rkb 724554 rat Iddm17 Insulin dependent diabetes mellitus QTL 17 11 0.001 10847 D11Mit8 34130 D11Mgh6 10911 D11Wox3 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) pancreas inflammation Chronic Pancreatitis;type 1 diabetes mellitus 634732 9329965 11 22660494 93518069 2 - by one flank and peak markers 11 19445919 87759784 2 - by one flank and peak markers backcross LETOxPKDP 68149 724576 TM KDP/Tky 11 19016272 90463843 2 - by one flank and peak markers 11 18976208 86241447 2 - by one flank and peak markers 724555 rat Bp150 Blood pressure QTL 150 10 1.0E-4 36203 D10Rat27 37460 D10Rat93 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 704345 12939233 10 74127825 80788180 1 - by flanking markers 10 77091834 81887390 1 - by flanking markers 724577 SS.LEW-(D10Rat27-Igfbp4)/Ayd 10 75983662 80946110 1 - by flanking markers 10 73452992 78210622 1 - by flanking markers 724556 rat Pur2 Proteinuria QTL 2 10 5.5 62429 D10Uia2 34896 D10Rat17 66468 D10Mco57 urine protein amount (VT:0005160) urine protein level (CMO:0000591) increased urine protein level proteinuria 634617 12707388 10 22763210 93641934 1 - by flanking markers 10 22915259 95066632 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 10 22901497 93886300 1 - by flanking markers 10 22427500 90627625 1 - by flanking markers 724557 rat Plsm1 Polydactyly-luxate syndrome (PLS) morphotypes QTL 1 4 3.0E-4 2901 Il6 forelimb integrity trait (VT:0010562) front foot phalanges count (CMO:0001947) polydactyly polydactyly 632346 8997636 2901 Il6 4 1 25597824 5 - by peak with adj size 4 1 22959087 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 4 1 25545519 5 - by peak with adj size 4 1 27716890 5 - by peak with adj size 724558 rat Plsm2 Polydactyly-luxate syndrome (PLS) morphotypes QTL 2 4 3.0E-4 2004 A2m hindlimb integrity trait (VT:0010563) hind foot phalanges count (CMO:0001949) polydactyly polydactyly 632346 8997636 2004 A2m 4 198918089 243918089 5 - by peak with adj size 4 135628567 180628567 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 4 131834282 176834282 5 - by peak with adj size 4 132422778 177422778 5 - by peak with adj size 724559 rat Pancm1 Pancreatic morphology QTL 1 1 7.1 8.0 43424 D1Wox10 3750 Spn 11060 D1Wox23 islet of Langerhans morphology trait (VT:0005215) pancreatic islet damage composite score (CMO:0001156) abnormal pancreatic islet morphology type 2 diabetes mellitus 61083 9169130 3750 Spn 1 205576290 244066294 1 - by flanking markers 1 186391887 220639539 1 - by flanking markers Intercross 13MxWKY 61103 61112 WKY 13M 1 198585664 236763415 1 - by flanking markers 1 181759564 214537555 1 - by flanking markers 724560 rat Plsm3 Polydactyly-luxate syndrome (PLS) morphotypes QTL 3 7 3.0E-4 33721 D7Mit17 tibia length (VT:0004357) tibia length (CMO:0000450) short tibia Congenital Limb Deformities 632346 8997636 7 1 37162479 5 - by peak with adj size 7 1 35575619 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 7 1 37009673 5 - by peak with adj size 7 1 34000259 5 - by peak with adj size 724561 rat Plsm4 Polydactyly-luxate syndrome (PLS) morphotypes QTL 4 11 3.0E-4 3761 Sst forelimb integrity trait (VT:0010562) front foot phalanges count (CMO:0001947) polydactyly polydactyly 632346 8997636 11 57874854 93518069 5 - by peak with adj size 11 56625623 87759784 5 - by peak with adj size intercross SHR/OlaxBN-lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 11 57858810 90463843 5 - by peak with adj size 11 54457534 86241447 5 - by peak with adj size 724562 rat Rends1 Renal damage susceptibility QTL 1 1 0.05 60787 D1Wox6 43424 D1Wox10 kidney glomerulus integrity trait (VT:0010546) index of glomerular damage (CMO:0001135) abnormal kidney vasculature morphology;abnormal renal glomerulus morphology;increased urine protein level end stage renal disease;proteinuria 632218 10454439 1 138777913 244066407 1 - by flanking markers 1 131956599 220639653 1 - by flanking markers 61100 628908 SHR/Ola SHR.BN-(D1Mit3-Igf2)/Ipcv 1 137787261 236763528 1 - by flanking markers 737972 BN/Crl 1 169537671 214537671 4 - by one flank marker only 724563 rat Uae10 Urinary albumin excretion QTL 10 11 6.0 36906 D11Rat17 37512 D11Rat50 39698 D11Rat67 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 634617 12707388 11 31929422 90087579 1 - by flanking markers 11 28213024 84841212 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 11 28314665 86994795 1 - by flanking markers 11 27672410 82846715 1 - by flanking markers 724564 rat Uae11 Urinary albumin excretion QTL 11 13 5.7 11231 D13Wox5 37240 D13Rat63 38990 D13Rat58 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria Albuminuria 634617 12707388 13 55560677 87877411 1 - by flanking markers 13 46269934 80482429 1 - by flanking markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 13 64501351 82995671 2 - by one flank and peak markers 13 59492522 77046890 2 - by one flank and peak markers 724565 rat Tcas5 Tongue tumor susceptibility QTL 5 19 10.04 33581 D19Mit1 10418 D19Mit6 11471 D19Mit9 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 2503;2944 Nqo1;Junb semidominant 19 16155908 54715514 2 - by one flank and peak markers 19 11456899 41612881 2 - by one flank and peak markers intercross DAxWF 60997 61007 DA WF 19 5007571 43907843 2 - by one flank and peak markers 19 9977753 39654489 2 - by one flank and peak markers 724566 rat Uae12 Urinary albumin excretion QTL 12 19 5.0 39128 D19Rat34 66451 D19Uia1 39018 D19Rat29 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria Albuminuria 634617 12707388 19 2413720 72914587 2 - by one flank and peak markers 19 2264957 59218465 2 - by one flank and peak markers intercross SS/JrMcoxSHR/NHsd 724573 724574 SS/JrTol SHR/NHsd 19 2432963 62275575 2 - by one flank and peak markers 19 2187927 56457239 2 - by one flank and peak markers 724567 rat Tcas6 Tongue tumor susceptibility QTL 6 1 6.85 34037 D1Mit1 33959 D1Mit3 39428 D1Rat320 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 2466 Cyp2b1 semidominant 1 91268282 162692800 2 - by one flank and peak markers 1 92101613 146971983 2 - by one flank and peak markers intercross DAxWF 60997 61007 DA WF 1 95304961 156446783 2 - by one flank and peak markers 1 92948896 144267916 2 - by one flank and peak markers 724568 rat Uae13 Urinary albumin excretion QTL 13 2 4.4 35857 D2Rat36 34884 D2Rat57 39374 D2Rat126 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 634633;634617 12799471;12707388 2 187719129 243539067 2 - by one flank and peak markers 2 161170272 218568266 2 - by one flank and peak markers intercross SS/JrxSHR/Rkb 10041 631696 SS/Jr SHR/FubRkb 2 149114878 225501939 1 - by flanking markers 2 143157029 210020885 1 - by flanking markers 731164 rat Uae25 Urinary albumin excretion QTL 25 9 3.5 1.0E-4 36984 D9Rat29 36027 D9Rat3 36556 D9Rat10 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 9 28304251 107462796 1 - by flanking markers 9 22066101 99799902 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 9 29466970 107878528 1 - by flanking markers 9 25661188 100929786 1 - by flanking markers 731165 rat Uae21 Urinary albumin excretion QTL 21 4 2.4 1.0E-4 38458 D4Rat95 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 4 170855470 215855470 5 - by peak with adj size 4 108641841 153641841 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 4 106347236 151347236 5 - by peak with adj size 4 106649412 151649412 5 - by peak with adj size 731166 rat Mamtr2 Mammary tumor resistance QTL 2 2 1.0E-4 33822 D2Mit29 67798 D2Uwm14 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 724790 14522903 semidominant 2 5396621 10117085 1 - by flanking markers 2 5601528 10539334 1 - by flanking markers intercross WFxCOP 728387 WF.COP-(D2Mit29-D2Uwm13)/Uwm 2 5417336 10246458 1 - by flanking markers 2 7887772 12654247 1 - by flanking markers 731167 rat Glom4 Glomerulus QTL 4 2 2.4 0.0082 37018 D2Rat14 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 730279 14638907 2 39326015 84326015 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 2 20276981 65276981 5 - by peak with adj size 2 20304672 65304672 5 - by peak with adj size 731168 rat Bp154 Blood pressure QTL 154 1 3.4 2969 Klk1 43424 D1Wox10 621323 Phox2a arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure hypertension 730283 14623828 1 101196673 244066407 1 - by flanking markers 1 94624828 220639653 1 - by flanking markers backcross 731189 SHRSP.WKY-(Klk1-D1Rat116)/Izm 1 100131562 236763528 1 - by flanking markers 1 94642644 214537671 1 - by flanking markers 731169 rat Bp153 Blood pressure QTL 153 1 0.001 37974 D1Rat211 36550 D1Rat12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728381;2312639 14597851;19423552 Bp344 (sub_region) 1 35077728 37526296 1 - by flanking markers 17 1147796 3643283 1 - by flanking markers backcross 731190 SS.LEW-(D1Rat211-D1Rat18)/Mco 1 33667777 36129328 1 - by flanking markers 1 31050840 33492143 1 - by flanking markers 731170 rat Pur3 Proteinuria QTL 3 15 2.3 5.0E-4 37702 D15Rat66 urine protein amount (VT:0005160) urine protein excretion rate (CMO:0000759) increased urine protein level proteinuria 730279 14638907 15 1803102 46803102 5 - by peak with adj size 15 1 44351302 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 15 1 42844179 5 - by peak with adj size 15 1 41686771 5 - by peak with adj size 731171 rat Glom6 Glomerulus QTL 6 9 2.8 3.0E-4 35691 D9Rat5 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 730279 14638907 9 70670941 115670941 5 - by peak with adj size 9 62686917 107686917 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 9 70942881 115942881 5 - by peak with adj size 9 64573531 109573531 5 - by peak with adj size 731172 rat Bp151 Blood pressure QTL 151 3 0.04 10260 D3Rat52 39050 D3Rat130 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 724791;1599557 14517349;17143582 3 19410399 55227748 1 - by flanking markers 3 14051872 44551542 1 - by flanking markers backcross 731192 SS.LEW-(D3Rat52-D3Rat130)/Ayd 3 14090411 48562146 1 - by flanking markers 3 18311454 47233430 1 - by flanking markers 731173 rat Uae22 Urinary albumin excretion QTL 22 6 10.1 38608 D6Rat106 36191 D6Rat6 36990 D6Rat12 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279;1642911;1600609 14638907;17953514;17167120 2151;3851;70907 Arg2;Tgfb3;Actn1 6 78348236 132488565 1 - by flanking markers 6 68036028 123455207 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 6 68781170 147991367 2 - by one flank and peak markers 6 65531555 140994061 2 - by one flank and peak markers 731174 rat Uae23 Urinary albumin excretion QTL 23 7 2.4 0.0042 35304 D7Rat4 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 7 114463225 143501887 5 - by peak with adj size 7 112114092 143002779 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 7 114825174 145729302 5 - by peak with adj size 7 104603555 135012528 5 - by peak with adj size 731175 rat Uae20 Urinary albumin excretion QTL 20 1 3.5 0.0018 35909 D1Rat74 35457 D1Rat90 35945 D1Rat75 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 1 248763714 289137268 1 - by flanking markers 1 227005311 267111153 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 1 241482188 281795785 1 - by flanking markers 1 221264111 259647894 1 - by flanking markers 731176 rat Glom5 Glomerulus QTL 5 7 2.5 0.0035 35118 D7Rat7 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria;proteinuria 730279 14638907 7 106256195 143501887 5 - by peak with adj size 7 103894800 143002779 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 7 106564316 145729302 5 - by peak with adj size 7 96670164 135012528 5 - by peak with adj size 731177 rat Uae26 Urinary albumin excretion QTL 26 15 2.4 0.025 40106 D15Rat102 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 15 78999675 114627140 5 - by peak with adj size 15 75200650 109758846 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 15 75527634 111246239 5 - by peak with adj size 15 67588667 101769107 5 - by peak with adj size 731178 rat Oia7 Oil induced arthritis QTL 7 4 1.0E-4 60413 D4Got126 60422 D4Got136 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 730281;1642519;2307198 12915467;17665455;18540828 2976;2977;2978;619983;620537;1359528 Klrc1;Klrc2;Klrd1;C1s;C3ar1;Clec4a3 additive 4 222677930 223964695 1 - by flanking markers 4 159298584 160528447 1 - by flanking markers backcross 731193 DA.PVG-(D4Rat141-D4Mgh11) 4 155657051 156945571 1 - by flanking markers 4 156050654 157232313 1 - by flanking markers 731179 rat Mamtr3 Mammary tumor resistance QTL 3 2 1.0E-4 67800 D2Uwm17 36470 D2Rat16 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 407571689;724790 22993404;14522903 recessive 2 50381686 62691053 1 - by flanking markers 2 32051319 43376636 1 - by flanking markers intercross WFxCOP 728391 WF.COP-(D2Rat253-D2Uwm17)/Uwm 2 31224612 43643900 1 - by flanking markers 2 32373770 43665178 1 - by flanking markers 731180 rat Bp152 Blood pressure QTL 152 3 0.03 728034 D3Chm63 35795 D3Rat26 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 724791 14517349 3 61857234 101798901 1 - by flanking markers 3 51161661 90573782 1 - by flanking markers backcross 731194 SS.LEW-(D3Chm64-D3Rat17)/Ayd 3 55245276 95176874 1 - by flanking markers 3 53781112 91609953 1 - by flanking markers 731181 rat Uae27 Urinary albumin excretion QTL 27 X 2.7 0.0059 36111 DXRat8 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 X 1 44359160 5 - by peak with adj size X 18886934 63886934 5 - by peak with adj size backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub X 1 44092703 5 - by peak with adj size X 1 43491017 5 - by peak with adj size 731182 rat Uae24 Urinary albumin excretion QTL 24 8 6.4 35296 D8Rat53 36904 D8Rat19 36235 D8Rat35 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 730279 14638907 8 21869159 100352529 1 - by flanking markers 8 19815642 98451660 1 - by flanking markers backcross MWF/FubxSHR/Fub 731185 731186 MWF/Fub SHR/Fub 8 21813070 100873963 1 - by flanking markers 8 19331152 93965294 1 - by flanking markers 731183 rat Pia20 Pristane induced arthritis QTL 20 14 3.55 35713 D14Rat11 37030 D14Rat3 33551 D14Mit6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 730280 14624754 14 10676655 61976011 1 - by flanking markers 14 10340377 41608939 1 - by flanking markers backcross 731195 DA.E3-(D14Wox8-D14Rat64)/Rhd 14 10729268 61873323 1 - by flanking markers 14 9088978 39057237 1 - by flanking markers 731184 rat Mamtr4 Mammary tumor resistance QTL 4 2 3.0E-4 36205 D2Rat2 728007 D2M13Mit286 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 724790 14522903 semidominant 2 14095321 59095321 4 - by one flank marker only 2 14747814 59747814 4 - by one flank marker only intercross WFxCOP 728385 WF.COP-(D2Rat2-D2M13Mit286)/Uwm 2 14237830 59237830 4 - by one flank marker only 2 16491740 61491740 4 - by one flank marker only 734767 rat Niddm57 Non-insulin dependent diabetes mellitus QTL 57 1 37902 D1Rat169 42550 D1Rat459 body mass (VT:0001259) body weight (CMO:0000012) increased body weight;increased circulating cholesterol level Hypercholesterolemia;Hypertriglyceridemia;obesity 619679 11355573 1 251652807 289700417 1 - by flanking markers 1 229876870 267593558 1 - by flanking markers 734527 OLETF.F344-(D1Rat169-D1Rat459)/Got 1 244401175 282365384 1 - by flanking markers 1 224054293 260122809 1 - by flanking markers 734768 rat Niddm59 Non-insulin dependent diabetes mellitus QTL 59 1 40126 D1Rat306 42553 D1Rat461 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;decreased circulating cholesterol level;decreased total body fat amount;decreased triglyceride level obesity;type 2 diabetes mellitus 734465 12190994 1 268967725 288207792 1 - by flanking markers 1 248583506 266234812 1 - by flanking markers 734531 OLETF.F344-(D1Rat306-D1Rat461)/Got 1 235850810 280850810 4 - by one flank marker only 1 213843987 258843987 4 - by one flank marker only 734769 rat Niddm58 Non-insulin dependent diabetes mellitus QTL 58 1 36960 D1Rat76 42550 D1Rat459 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;decreased circulating insulin level;decreased circulating triglyceride level;decreased total body fat amount;improved glucose tolerance Insulin Resistance;obesity;type 2 diabetes mellitus 619683;2312611 11153534;19697080 additive Bw85 (maps to same region) 1 252243728 289700417 1 - by flanking markers 1 230411091 267593558 1 - by flanking markers 734528 OLETF.BN-(D1Rat76-D1Rat459)/Got 1 244992467 282365384 1 - by flanking markers 1 224569538 260122809 1 - by flanking markers 737818 rat Hcar12 Hepatocarcinoma resistance QTL 12 3 2.6 35745 D3Rat48 34411 D3Mgh14 35745 D3Rat48 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566 12154055 Hcar10 (interacts with);Hcar11 (interacts with);Hcar9 (interacts with) 3 35310614 130198834 1 - by flanking markers 3 25775548 118863223 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 3 30114912 123700444 1 - by flanking markers 3 29463235 118376539 1 - by flanking markers 737819 rat Hcas4 Hepatocarcinoma susceptibility QTL 4 16 4.43 33848 D16Mit2 10842 D16Mgh5 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) increased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566 12154055 Hcas3 (interacts with) 16 4954192 49892275 1 - by flanking markers 16 4304396 50266190 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 16 5013802 50169318 1 - by flanking markers 16 4227609 46975965 1 - by flanking markers 737820 rat Alc9 Alcohol consumption QTL 9 10 2.2 34361 D10Mgh25 39082 D10Rat118 41276 D10Rat182 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212;4890458;7401255 14634485;20705418;23596094 2401;61836;1304560;1311614;1359733;1563691 Crebbp;Clcn7;Fahd1;Gnptg;Trap1;Mapk8ip3 additive Alc10 (interacts with);Alc11 (interacts with);Alc12 (maps to same region,interacts with);Alc13 (interacts with);Alc4 (interacts with);Alc5 (maps to same region);Alc6 (interacts with);Alc7 (interacts with);Alc8 (interacts with);Foco17 (maps to same region) 10 4040517 19469666 1 - by flanking markers 10 5090008 19648894 1 - by flanking markers Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 10 5217199 19591669 1 - by flanking markers 10 5144027 19233348 1 - by flanking markers 737821 rat Hcar9 Hepatocarcinoma resistance QTL 9 4 3.7 35817 D4Rat40 34338 D4Mgh11 34174 D4Mgh7 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566 12154055 Hcar10 (interacts with);Hcar11 (interacts with);Hcar12 (interacts with) 4 165920699 230565226 1 - by flanking markers 4 106554769 171204531 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 4 105971071 168047091 2 - by one flank and peak markers 4 109866907 167139601 2 - by one flank and peak markers 737822 rat Alc10 Alcohol consumption QTL 10 12 2.2 11051 D12Mit2 34086 D12Mgh9 36490 D12Rat18 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212;7401255 14634485;23596094 additive Alc11 (interacts with);Alc12 (interacts with);Alc13 (interacts with);Alc4 (interacts with);Alc5 (interacts with);Alc6 (maps to same region);Alc7 (interacts with);Alc8 (interacts with);Alc9 (interacts with);Foco19 (maps to same region);Foco5 (maps to same region);Foco6 (maps to same region) 12 24662983 47758715 1 - by flanking markers 12 20932559 41447890 1 - by flanking markers Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 12 22650702 45946937 1 - by flanking markers 12 19610870 40218516 1 - by flanking markers 737823 rat Alc12 Alcohol consumption QTL 12 10 4.5 41276 D10Rat182 35012 D10Rat46 41524 D10Rat180 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212;7401255 14634485;23596094 additive Alc10 (interacts with);Alc11 (interacts with);Alc13 (interacts with);Alc4 (interacts with);Alc5 (maps to same region);Alc6 (interacts with);Alc7 (interacts with);Alc8 (interacts with);Alc9 (maps to same region,interacts with);Foco17 (maps to same region) 10 17443258 19620793 1 - by flanking markers 10 17515123 19815204 1 - by flanking markers Intercross HAD2xLAD2 731187 731188 Iusm:HAD2 Iusm:LAD2 10 17555386 19743866 1 - by flanking markers 10 17245513 19388279 1 - by flanking markers 737824 rat Hcar10 Hepatocarcinoma resistance QTL 10 8 2.9 36117 D8Rat46 35905 D8Rat21 33973 D8Mit2 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566;737837 12154055 Hcar11 (interacts with);Hcar12 (interacts with);Hcar9 (interacts with) 8 61319409 89073444 1 - by flanking markers 8 43313902 87122960 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 8 44219197 89542960 1 - by flanking markers 8 40713066 82925667 1 - by flanking markers 737825 rat Alc13 Alcohol consumption QTL 13 16 4.5 33848 D16Mit2 37854 D16Rat30 45312 D16Rat124 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212 14634485 additive Alc10 (interacts with);Alc11 (maps to same region);Alc12 (interacts with);Alc4 (interacts with);Alc5 (interacts with);Alc6 (interacts with);Alc7 (maps to same region);Alc8 (interacts with);Alc9 (interacts with) 16 4954192 18239063 1 - by flanking markers 16 4304396 16536977 1 - by flanking markers Intercross HAD2xLAD2 731187 731188 Iusm:HAD2 Iusm:LAD2 16 5013802 18360147 1 - by flanking markers 16 4227609 16039848 1 - by flanking markers 737826 rat Alc11 Alcohol consumption QTL 11 16 3.2 33848 D16Mit2 40234 D16Rat60 34066 D16Mgh1 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) alcohol preference alcohol use disorder 731212 14634485 additive Alc10 (interacts with);Alc12 (interacts with);Alc13 (maps to same region);Alc4 (interacts with);Alc5 (interacts with);Alc6 (interacts with);Alc7 (maps to same region);Alc8 (interacts with);Alc9 (interacts with) 16 4954192 63674088 1 - by flanking markers 16 4304396 64081533 1 - by flanking markers Intercross HAD1xLAD1 631844 631845 Iusm:HAD1 Iusm:LAD1 16 5013802 64012784 1 - by flanking markers 16 4227609 60252231 1 - by flanking markers 737827 rat Hcar11 Hepatocarcinoma resistance QTL 11 6 4.4 34835 D6Rat28 35198 D6Rat11 36665 D6Rat14 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased hepatoma incidence Experimental Liver Neoplasms 629566 12154055 Hcar10 (interacts with);Hcar12 (interacts with);Hcar9 (interacts with) 6 52556973 124634525 1 - by flanking markers 6 41300997 115238799 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 6 86422697 115379601 2 - by one flank and peak markers 6 82523650 110548006 2 - by one flank and peak markers 737828 rat Hcas3 Hepatocarcinoma susceptibility QTL 3 1 4.9 33959 D1Mit3 37982 D1Rat223 35615 D1Rat70 liver integrity trait (VT:0010547) liver tumorous lesion volume to total liver volume ratio (CMO:0001082) increased hepatoma incidence Experimental Liver Neoplasms;hepatocellular carcinoma 629566;737884 12154055;15185337 Hcas4 (interacts with) 1 162692213 250573008 1 - by flanking markers 1 146971846 228781113 1 - by flanking markers backcross BN/CrlixF344/Crli 737690 737691 F344/Crli BN/Crli 1 156446196 243311614 1 - by flanking markers 1 144267353 222987745 1 - by flanking markers 737856 rat Edpm10 Estrogen-dependent pituitary mass QTL 10 14 2.83 6.5 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 61074 9337394 intercross 10008 61109 BN/SsNHsd F344/NHsd 737973 rat Pia21 Pristane induced arthritis QTL 21 20 4.8 11428 D20Wox3 37594 D20Rat41 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) decreased susceptibility to induced joint inflammation Experimental Arthritis 631850;2307198;2300074;1582387;61031 12817024;18540828;18606636;16804090;10640775 dominant Pia1 (maps to same region) 20 6118863 6935875 1 - by flanking markers 20 3660646 4740814 1 - by flanking markers 737870 DA.E3-(D20Wox3-D20Mgh4)/Rhd 20 4039317 4855475 1 - by flanking markers 20 3621656 4606812 1 - by flanking markers 737974 rat Bp161 Blood pressure QTL 161 1 0.002 10923 D1Wox19 10165 D1Wox34 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 61051 9774356 Bp160 (maps to same region);Bp29 (interacts with) 1 182435183 204942418 1 - by flanking markers 1 168382329 185690881 1 - by flanking markers 629487 SHR.WKY-(D1Wox19-D1Wox34)/Njs 1 175447162 197963658 1 - by flanking markers 1 164747558 181133855 1 - by flanking markers 737975 rat Bw122 Body weight QTL 122 1 9.11 0.005 42553 D1Rat461 42550 D1Rat459 35457 D1Rat90 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 737696 14756694 1 288207586 289700417 1 - by flanking markers 1 266234605 267593558 1 - by flanking markers 737869 OLETF.BN-(D1Rat461-D1Rat459)/Got 1 280850604 282365384 1 - by flanking markers 1 258843780 260122809 1 - by flanking markers 737976 rat Pia24 Pristane induced arthritis QTL 24 6 44173 D6Wox5 37718 D6Rat90 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 728382 14611807 6 126582753 156897508 4 - by one flank marker only 6 117361909 147636619 4 - by one flank marker only 737873 DA.E3-(D6Wox5-D6Rat90)/Rhd 6 117355600 147991367 4 - by one flank marker only 6 112636280 140994061 4 - by one flank marker only 737977 rat Bp160 Blood pressure QTL 160 1 0.001 10923 D1Wox19 34011 D1Mit2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension 61051 9774356 Bp161 (maps to same region);Bp29 (interacts with) 1 204942418 249942418 4 - by one flank marker only 1 134980682 185690881 1 - by flanking markers 629482 WKY.SHR-(D1Wox19-D1Mit2)/Njs 1 197963658 242963658 4 - by one flank marker only 1 181133855 226133855 4 - by one flank marker only 737978 rat Pia23 Pristane induced arthritis QTL 23 4 5.3 10158 D4Arb16 34338 D4Mgh11 36143 D4Rat60 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 631850;2300074;1582387 12817024;18606636;16804090 dominant 4 196023944 230565226 1 - by flanking markers 4 133939407 171204531 1 - by flanking markers 737872 DA.E3-(D4Mit16-D4Mgh11)/Rhd 4 131532269 168047091 1 - by flanking markers 4 131730738 167139601 1 - by flanking markers 737979 rat Pia22 Pristane induced arthritis QTL 22 12 53.1 40986 D12Rat72 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 631850;629560;2300074;1582387 12817024;12571866;18606636;16804090 61307 Ncf1 dominant 12 4475957 49475957 5 - by peak with adj size 12 530865 45530865 5 - by peak with adj size 737871 DA.E3-(D12Got46-D12Rat26)/Rhd 12 2475687 47475687 5 - by peak with adj size 12 1 44465750 5 - by peak with adj size 738005 rat Anxrr11 Anxiety related response QTL 11 18 3.4 37568 D18Rat55 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity Hyperkinesis;anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 18 30846397 75846397 5 - by peak with adj size 18 32356601 77356601 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 18 31608424 76608424 5 - by peak with adj size 18 30039813 75039813 5 - by peak with adj size 738006 rat Anxrr14 Anxiety related response QTL 14 1 4.0 3.5E-4 32.0 34074 D1Mgh8 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) abnormal response to new environment 731213 12972953 Anxrr12 (maps to same region);Anxrr13 (interacts with,maps to same region);Anxrr15 (interacts with) 1 147499447 192499447 5 - by peak with adj size 1 133624682 178624682 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 1 141296374 186296374 5 - by peak with adj size 1 130636910 175636910 5 - by peak with adj size 738007 rat Anxrr7 Anxiety related response QTL 7 2 4.4 41300 D2Rat221 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased locomotor activity;increased anxiety-related response anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 2 142866854 187866854 5 - by peak with adj size 2 123254875 168254875 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 2 123456539 168456539 5 - by peak with adj size 2 118189491 163189491 5 - by peak with adj size 738008 rat Hcar14 Hepatocarcinoma resistance QTL 14 18 4.3 38146 D18Rat50 39278 D18Rat44 36816 D18Rat12 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion number (CMO:0001462) decreased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 18 52220612 86114102 1 - by flanking markers 18 53847682 86863412 1 - by flanking markers intercross 60998 70509 COP F344/NRrrc 18 53033494 87080053 1 - by flanking markers 18 51464733 83218561 1 - by flanking markers 738009 rat Sach4 Saccharine consumption QTL 4 4 4.9 1.6E-5 46.0 36540 D4Rat24 10048 D4Mit20 37100 D4Rat52 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) saccharin preference;saccharin preference alcohol use disorder 731213 12972953 3197 Npy Alc14 (maps to same region);Alc15 (interacts with);Alc16 (interacts with,maps to same region);Alc17 (interacts with);Sach5 (interacts with) 4 58395060 221511103 1 - by flanking markers 4 58421110 158108528 1 - by flanking markers intercross WKYxHEP 61103 738038 WKY HEP 4 58640017 154427984 1 - by flanking markers 4 59948935 154902892 1 - by flanking markers 738010 rat Lnnr3 Liver neoplastic nodule remodeling QTL 3 2 2.94 41538 D2Rat199 40786 D2Rat187 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 2 1 60242597 2 - by one flank and peak markers 2 1 41032214 4 - by one flank marker only intercross 60998 70509 COP F344/NRrrc 2 1 41179397 2 - by one flank and peak markers 2 1 41244106 2 - by one flank and peak markers 738011 rat Anxrr9 Anxiety related response QTL 9 8 6.1 35429 D8Rat7 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased locomotor activity;increased anxiety-related response anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with) 8 101323382 132457389 5 - by peak with adj size 8 98332663 129041809 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 8 102051964 133307652 5 - by peak with adj size 8 93535351 123900184 5 - by peak with adj size 738012 rat Anxrr3 Anxiety related response QTL 3 2 3.8 37880 D2Rat94 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) increased anxiety-related response anxiety disorder 737695;737687 14739700;14722724 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with);Stresp2 (interacts with);Stresp3 (interacts with) 2 27052767 72052767 5 - by peak with adj size 2 8682344 53682344 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 2 7893600 52893600 5 - by peak with adj size 2 9023519 54023519 5 - by peak with adj size 738013 rat Alc15 Alcohol consumption QTL 15 2 4.1 2.2E-4 18.0 38466 D2Rat118 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) abnormal alcohol consumption alcohol use disorder 731213 12972953 Alc14 (interacts with);Alc16 (interacts with);Alc17 (interacts with);Sach4 (interacts with);Sach5 (interacts with) 2 217431609 262431609 5 - by peak with adj size 2 192489056 237489056 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 2 199380312 244380312 5 - by peak with adj size 2 184165752 229165752 5 - by peak with adj size 738014 rat Anxrr15 Anxiety related response QTL 15 8 3.6 0.005 32.0 36327 D8Rat2 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) abnormal response to new environment 731213 12972953 Anxrr12 (interacts with);Anxrr13 (interacts with);Anxrr14 (interacts with) 8 103904881 132457389 5 - by peak with adj size 8 100915338 129041809 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 8 104682575 133307652 5 - by peak with adj size 8 95718998 123900184 5 - by peak with adj size 738015 rat Pia9 Pristane induced arthritis QTL 9 4 4.5 0.048 10561 D4Wox20 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 629560;629570;2307198 12571866;11090241;18540828 Pia11 (interacts with) 4 141344184 186344184 5 - by peak with adj size 4 81916057 126916057 5 - by peak with adj size 737859 DA.PVG.1AV1-(D4Mgh17-D4Rat56) 4 76567036 121567036 5 - by peak with adj size 4 80694870 125694870 5 - by peak with adj size 738016 rat Alc16 Alcohol consumption QTL 16 4 3.6 1.5E-4 35.0 36540 D4Rat24 10048 D4Mit20 35070 D4Rat57 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) alcohol preference alcohol use disorder 731213 12972953 3197 Npy Alc14 (maps to same region);Alc15 (interacts with);Alc17 (interacts with);Sach4 (interacts with,maps to same region);Sach5 (interacts with) 4 58395060 221511103 1 - by flanking markers 4 58421110 158108528 1 - by flanking markers intercross WKYxHEP 61103 738038 WKY HEP 4 58640017 154427984 1 - by flanking markers 4 59948935 154902892 1 - by flanking markers 738017 rat Hcas7 Hepatocarcinoma susceptibility QTL 7 15 2.91 38922 D15Rat38 41114 D15Rat89 35350 D15Rat3 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) increased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 15 2310393 57258002 1 - by flanking markers 15 2306220 43057384 2 - by one flank and peak markers intercross 60998 70509 COP F344/NRrrc 15 2327877 53535766 1 - by flanking markers 15 2266368 46921453 1 - by flanking markers 738018 rat Anxrr4 Anxiety related response QTL 4 5 5.1 35348 D5Rat45 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) decreased anxiety-related response anxiety disorder 737695;10053640;737687 14739700;21029000;14722724 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with);Scort27 (maps to same region);Stresp1 (interacts with);Stresp3 (interacts with) 5 140071351 177180328 5 - by peak with adj size 5 136765530 173096209 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 5 136354114 173707219 5 - by peak with adj size 5 130130159 166875058 5 - by peak with adj size 738019 rat Anxrr10 Anxiety related response QTL 10 3 3.9 39912 D3Rat180 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity Hyperkinesis;anxiety disorder 737695 14739700 Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 3 46967386 91967386 5 - by peak with adj size 3 36264666 81264666 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 3 40422921 85422921 5 - by peak with adj size 3 38517803 83517803 5 - by peak with adj size 738020 rat Pia8 Pristane induced arthritis QTL 8 1 4.7 34035 D1Mit15 11144 D1Wox11 34662 D1Mgh2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 629570;2307198;2300074;1582387;2302026 11090241;18540828;18606636;16804090;14674011 dominant Pia31 (maps to same region) 1 3228155 63399376 1 - by flanking markers 1 1595127 64145956 1 - by flanking markers intercross 631161 737950 DXE3/Ztm DA/Ztm 1 1 64407321 2 - by one flank and peak markers 1 1 65833076 2 - by one flank and peak markers 738021 rat Hcar13 Hepatocarcinoma resistance QTL 13 4 4.3 41102 D4Rat151 41578 D4Rat145 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) decreased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 4 1 31425512 4 - by one flank marker only 4 1 29414068 4 - by one flank marker only intercross 60998 70509 COP F344/NRrrc 4 1 31554484 4 - by one flank marker only 4 1 32584199 4 - by one flank marker only 738022 rat Anxrr13 Anxiety related response QTL 13 1 4.6 3.9E-4 24.0 34381 D1Mgh7 locomotor behavior trait (VT:0001392) number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514) abnormal response to new environment 731213 12972953 Anxrr12 (interacts with);Anxrr14 (interacts with,maps to same region);Anxrr15 (interacts with) 1 92100958 137100958 5 - by peak with adj size 1 83945235 128945235 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 1 91093646 136093646 5 - by peak with adj size 1 83547917 128547917 5 - by peak with adj size 738023 rat Alc17 Alcohol consumption QTL 17 6 3.1 0.003 38.0 35963 D6Rat46 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) alcohol preference alcohol use disorder 731213 12972953 Alc14 (interacts with);Alc15 (interacts with);Alc16 (interacts with);Sach4 (interacts with);Sach5 (interacts with) 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 738024 rat Sach5 Saccharine consumption QTL 5 6 3.9 3.9E-4 31.0 40624 D6Rat148 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) saccharin preference;saccharin preference alcohol use disorder 731213 12972953 Alc14 (interacts with);Alc15 (interacts with);Alc16 (interacts with);Alc17 (interacts with);Sach4 (interacts with) 6 9458699 54458699 5 - by peak with adj size 6 1 43326782 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 6 1 44570292 5 - by peak with adj size 6 1 43394190 5 - by peak with adj size 738025 rat Stresp3 Stress response QTL 3 X 4.61 0.0066 40448 DXRat127 10609 DXWox31 41530 DXRat104 stress-related behavior trait (VT:0010451) defensive burying - approach abnormal coping response;increased anxiety-related response 737687 14722724 additive Anxrr3 (interacts with);Anxrr4 (interacts with) X 107760007 154597545 2 - by one flank and peak markers X 124590224 160699376 2 - by one flank and peak markers intercross WKYxF344 61103 70509 WKY F344/NRrrc X 107886746 152409805 1 - by flanking markers X 100567703 150256146 1 - by flanking markers 738026 rat Lnnr5 Liver neoplastic nodule remodeling QTL 5 13 3.29 33733 D13Mit2 40568 D13Rat152 36506 D13Rat32 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 13 69987122 96143898 1 - by flanking markers 13 62072299 94306205 2 - by one flank and peak markers intercross 60998 70509 COP F344/NRrrc 13 65008245 91629354 1 - by flanking markers 13 59874408 85581182 1 - by flanking markers 738027 rat Lnnr6 Liver neoplastic nodule remodeling QTL 6 13 3.3 36506 D13Rat32 40568 D13Rat152 40568 D13Rat152 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 13 85295639 96143898 1 - by flanking markers 13 78189125 111154910 4 - by one flank marker only intercross 60998 70509 COP F344/NRrrc 13 80403559 91629354 1 - by flanking markers 13 74862117 85581182 1 - by flanking markers 738028 rat Anxrr12 Anxiety related response QTL 12 1 4.9 1.0E-5 29.0 34074 D1Mgh8 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) abnormal response to new environment 731213 12972953 Anxrr13 (interacts with);Anxrr14 (maps to same region);Anxrr15 (interacts with) 1 147499447 192499447 5 - by peak with adj size 1 133624682 178624682 5 - by peak with adj size intercross WKYxHEP 61103 738038 WKY HEP 1 141296374 186296374 5 - by peak with adj size 1 130636910 175636910 5 - by peak with adj size 738029 rat Stresp2 Stress response QTL 2 X 3.4 4.0E-4 39210 DXRat64 10558 DXWox30 40448 DXRat127 stress-related behavior trait (VT:0010451) defensive burying - approach abnormal coping response;increased anxiety-related response 737687 14722724 additive Anxrr3 (interacts with);Anxrr5 (interacts with) X 120192403 143175497 1 - by flanking markers X 11470971 145580610 1 - by flanking markers intercross WKYxF344 61103 70509 WKY F344/NRrrc X 120045041 143145818 1 - by flanking markers X 112934952 138400867 1 - by flanking markers 738030 rat Anxrr8 Anxiety related response QTL 8 7 4.1 38606 D7Rat110 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased locomotor activity;increased anxiety-related response anxiety disorder 737695;10053640 14739700;21029000 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr9 (interacts with);Scort27 (maps to same region) 7 54375321 99375321 5 - by peak with adj size 7 50941627 95941627 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 7 54259512 99259512 5 - by peak with adj size 7 46590070 91590070 5 - by peak with adj size 738031 rat Alc14 Alcohol consumption QTL 14 4 7.6 3.0E-5 61.0 36540 D4Rat24 10048 D4Mit20 37868 D4Rat124 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) alcohol preference alcohol use disorder 731213 12972953 3197 Npy Alc15 (interacts with);Alc16 (maps to same region);Alc17 (interacts with);Sach4 (maps to same region);Sach5 (interacts with) 4 58395060 221511103 1 - by flanking markers 4 58421110 158108528 1 - by flanking markers intercross WKYxHEP 61103 738038 WKY HEP 4 58640017 154427984 1 - by flanking markers 4 59948935 154902892 1 - by flanking markers 738032 rat Hcas5 Hepatocarcinoma susceptibility QTL 5 1 3.12 40486 D1Rat437 36169 D1Rat89 35945 D1Rat75 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) increased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 1 198796985 287349830 1 - by flanking markers 1 180678929 265343617 1 - by flanking markers intercross 60998 70509 COP F344/NRrrc 1 191825895 279986079 1 - by flanking markers 1 176426412 257976495 1 - by flanking markers 738033 rat Anxrr6 Anxiety related response QTL 6 7 4.1 37004 D7Rat181 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) abnormal anxiety-related response anxiety disorder 737695 14739700 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr5 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with) 7 22193116 67193116 5 - by peak with adj size 7 18504784 63504784 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 7 22168412 67168412 5 - by peak with adj size 7 15573889 60573889 5 - by peak with adj size 738034 rat Anxrr5 Anxiety related response QTL 5 6 5.9 39578 D6Rat117 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) decreased anxiety-related response anxiety disorder 737695;10053640;737687 14739700;21029000;14722724 Anxrr10 (interacts with);Anxrr11 (interacts with);Anxrr3 (interacts with);Anxrr4 (interacts with);Anxrr6 (interacts with);Anxrr7 (interacts with);Anxrr8 (interacts with);Anxrr9 (interacts with);Srcrt6 (maps to same region);Stresp1 (interacts with);Stresp2 (interacts with) 6 97798491 142798491 5 - by peak with adj size 6 88615514 133615514 5 - by peak with adj size intercross SHR/OlaxBN-Lx/Cub 61100 61117 SHR/Ola BN-Lx/Cub 6 88507712 133507712 5 - by peak with adj size 6 84130881 129130881 5 - by peak with adj size 738035 rat Stresp1 Stress response QTL 1 X 4.96 1.1E-5 38374 DXRat67 39210 DXRat64 38374 DXRat67 stress-related behavior trait (VT:0010451) defensive burying - coping abnormal coping response;increased anxiety-related response 737687 14722724 Anxrr4 (interacts with);Anxrr5 (interacts with) X 44859631 120192631 1 - by flanking markers X 11471200 62951569 1 - by flanking markers intercross WKYxF344 61103 70509 WKY F344/NRrrc X 44557974 120045269 1 - by flanking markers X 41304447 112935181 1 - by flanking markers 738036 rat Lnnr4 Liver neoplastic nodule remodeling QTL 4 13 3.64 35543 D13Rat21 35975 D13Rat7 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) decreased liver tumor incidence Experimental Liver Neoplasms 737884 15185337 13 1 52710812 2 - by one flank and peak markers 13 1 43835207 2 - by one flank and peak markers intercross 60998 70509 COP F344/NRrrc 13 1 47622148 2 - by one flank and peak markers 13 1 42356786 2 - by one flank and peak markers 738037 rat Hcas6 Hepatocarcinoma susceptibility QTL 6 14 2.93 35713 D14Rat11 41138 D14Rat94 37828 D14Rat39 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) increased hepatoma incidence Experimental Liver Neoplasms 737884 15185337 14 61976011 88669930 1 - by flanking markers 14 41608939 89192873 1 - by flanking markers intercross 60998 70509 COP F344/NRrrc 14 61873323 88870994 1 - by flanking markers 14 39057237 83368335 1 - by flanking markers 1298065 rat Scl16 Serum cholesterol level QTL 16 8 3.8 7.0 41026 D8Rat153 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2016 Acat1 8 33617573 78617573 5 - by peak with adj size 8 33897608 78897608 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 8 35041414 80041414 5 - by peak with adj size 8 30856404 75856404 5 - by peak with adj size 1298066 rat Bp159 Blood pressure QTL 159 13 0.004 3804 Syt2 61281 D13M1Mit108 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure;increased systemic arterial blood pressure;increased systemic arterial blood pressure hypertension;hypertension 61047;61040 9271663;9685318 13 56621954 101621954 4 - by one flank marker only 13 47690518 92690518 4 - by one flank marker only 737864 SS.SR-(D13Mit9-D13Mit1)/Jr 13 51569248 96569248 4 - by one flank marker only 13 46088046 91088046 4 - by one flank marker only 1298067 rat Scl15 Serum cholesterol level QTL 15 5 4.8 0.001 10.0 33678 D5Mit10 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 5 38938687 83938687 5 - by peak with adj size 5 35474610 80474610 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 5 34402409 79402409 5 - by peak with adj size 5 33215665 78215665 5 - by peak with adj size 1298068 rat Bp167 Blood pressure QTL 167 3 0.004 2534 Edn3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61042 7963489 2534 Edn3 3 156414290 183740530 5 - by peak with adj size 3 144002709 171063335 5 - by peak with adj size 10040 10041 SR/Jr SS/Jr 3 150368003 177699992 5 - by peak with adj size 3 141074471 169034231 5 - by peak with adj size 1298069 rat Bp168 Blood pressure QTL 168 10 5.5 33632 D10Mit10 66563 D10Mco6 44786 D10Wox6 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61040 9685318 3185 Nos2 10 27082535 101157704 1 - by flanking markers 10 27184741 102587587 1 - by flanking markers 10041 60999 SS/Jr LEW 10 27237530 101482600 1 - by flanking markers 10 26521957 98003205 1 - by flanking markers 1298070 rat Scl18 Serum cholesterol level QTL 18 5 3.7 7.0 35074 D5Rat23 blood LDL cholesterol amount (VT:0000181) calculated plasma low density lipoprotein cholesterol level (CMO:0001245) increased circulating LDL cholesterol level Hypercholesterolemia 737694 14739155 728889 Plin2 5 87410667 132410667 5 - by peak with adj size 5 84392127 129392127 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 5 83424556 128424556 5 - by peak with adj size 5 79584860 124584860 5 - by peak with adj size 1298071 rat Edpm12 Estrogen-dependent pituitary mass QTL 12 X 3.2 36301 DXRat9 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 629550 11003699 X 4687646 49687646 5 - by peak with adj size X 23620000 68620000 5 - by peak with adj size backcross 10008 61109 BN/SsNHsd F344/NHsd X 4282140 49282140 5 - by peak with adj size X 2927898 47927898 5 - by peak with adj size 1298072 rat Cia26 Collagen induced arthritis QTL 26 18 3.6 33814 D18Mit9 37488 D18Rat60 33814 D18Mit9 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 1285224;2307198;2300074;1582387 15334486;18540828;18606636;16804090 recessive Cia7 (interacts with) 18 57248312 87229863 5 - by peak with adj size 18 57870442 87265094 5 - by peak with adj size intercross 631182 737892 DA/BklArbN ACI/SegHsd 18 58196300 88201929 5 - by peak with adj size 18 54709769 83828827 5 - by peak with adj size 1298073 rat Cm13 Cardiac mass QTL 13 3 2.5 37510 D3Rat100 66449 D3Mco16 60801 D3Wox3 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight;increased systemic arterial blood pressure hypertension 69705 9922389 3 30841048 44344790 1 - by flanking markers 3 21201203 35237920 1 - by flanking markers 10040 10041 SR/Jr SS/Jr 3 25633366 39248391 1 - by flanking markers 3 25013911 38192233 1 - by flanking markers 1298074 rat Bp164 Blood pressure QTL 164 2 0.003 37018 D2Rat14 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728179 11980293 Bp165 (maps to same region) 2 61825950 235592880 1 - by flanking markers 2 165636169 210636169 4 - by one flank marker only 731191 SHRSP.WKY-(D2Rat14-D2Mgh12)/Gcrc 2 42776916 217498710 1 - by flanking markers 2 42804607 202447032 1 - by flanking markers 1298075 rat Scl17 Serum cholesterol level QTL 17 2 3.4 7.0 34864 D2Rat67 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 1298076 rat Bp166 Blood pressure QTL 166 2 9.0E-4 60798 D2Wox9 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728179 11980293 2756 Gstm2 Bp14 (maps to same region) 2 161271919 235592880 1 - by flanking markers 2 141259937 210636169 1 - by flanking markers 737863 SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc 2 141583337 217498710 1 - by flanking markers 2 136445150 202447032 1 - by flanking markers 1298077 rat Bp157 Blood pressure QTL 157 5 39600 D5Rat154 62518 D5Uia8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 619649;1643012;7495753 11875185;17938377;23757393 3170 Nfia Bp373 (sub_region) 5 79025214 124025214 4 - by one flank marker only 5 76964552 121964552 4 - by one flank marker only 728145 SS.LEW-(D5Rat130-D5Rat108)/Jr 1298078 rat Stresp5 Stress response QTL 5 10 2.99 2.5E-4 9.0 41394 D10Rat164 41584 D10Rat135 35256 D10Rat11 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 737981 15013833 10 43088682 108145987 1 - by flanking markers 10 43458380 108776963 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 10 43289657 108540162 1 - by flanking markers 10 42045676 104670812 1 - by flanking markers 1298079 rat Activ2 Activity QTL 2 8 9.5 1.0E-6 29.0 33858 D8Mit4 10169 D8Wox11 voluntary movement trait (VT:0003491) rearing measurement (CMO:0001515) increased exploration in new environment Hyperkinesis 631228 12660808 62388 Htr5b Activ1 (maps to same region) 8 44187546 89187546 4 - by one flank marker only 8 44484215 129041809 2 - by one flank and peak markers 61103 68186 WKY WKHA/N 8 45712344 90712344 4 - by one flank marker only 8 41866876 86866876 4 - by one flank marker only 1298080 rat Bp163 Blood pressure QTL 163 2 0.02 33739 D2Mit5 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased heart weight;increased systemic arterial blood pressure hypertension;hypertension 68910;69705;2301356 10642295;9922389;18819818 Bp132 (interacts with) 2 86560119 235592880 1 - by flanking markers 2 66680022 210636169 1 - by flanking markers 631280 WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc 2 66828049 217498710 1 - by flanking markers 2 66118275 202447032 1 - by flanking markers 1298081 rat Cia25 Collagen induced arthritis QTL 25 12 4.7 11053 D12Wox12 41962 D12Arb6 11053 D12Wox12 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis 1285224;1600250;2300074;1582387;2307198 15334486;17329308;18606636;16804090;18540828 61307 Ncf1 recessive Cia12 (maps to same region) 12 24663002 43150909 1 - by flanking markers 12 20932555 36894750 1 - by flanking markers intercross 631182 737892 DA/BklArbN ACI/SegHsd 12 22650721 41291738 1 - by flanking markers 12 19610889 35682913 1 - by flanking markers 1298082 rat Stresp4 Stress response QTL 4 4 34967 D4Rat15 36143 D4Rat60 36870 D4Rat33 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 737981 15013833 4 46704280 208908285 1 - by flanking markers 4 47889730 149560340 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 4 46898276 145611886 1 - by flanking markers 4 50119848 146803430 1 - by flanking markers 1298083 rat Bp158 Blood pressure QTL 158 2 2.62 2167 Atp1a1 2263 Camk2d arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 61038;61037 8040284;1363813 2 223440514 250484590 1 - by flanking markers 2 196657749 224108082 1 - by flanking markers 10041 60992 SS/Jr MNS 2 204003742 231132207 1 - by flanking markers 2 189020722 215287351 1 - by flanking markers 1298084 rat Thym4 Thymus enlargement QTL 4 1 10.68 2870 Igf2 11201 D1Mgh11 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) enlarged thymus Thymus Hyperplasia 70859 10792781 Thym1 (sub_region) 1 222722921 267722921 4 - by one flank marker only 1 202906624 247906624 4 - by one flank marker only 61118 61119 BUF/Mna WKY/NCrlCrlj 1 215828102 260828102 4 - by one flank marker only 1 197814409 242814409 4 - by one flank marker only 1298085 rat Bp165 Blood pressure QTL 165 2 6.0E-4 37018 D2Rat14 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 728179 11980293 Bp164 (maps to same region) 2 61825950 235592880 1 - by flanking markers 2 165636169 210636169 4 - by one flank marker only 737865 WKY.SHRSP-(D2Rat14-D2Mgh12) 2 42776916 217498710 1 - by flanking markers 2 42804607 202447032 1 - by flanking markers 1298086 rat Bp156 Blood pressure QTL 156 5 69549 D5Uwm31 34583 D5Rjr1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 619649;1643012;7495753 11875185;17938377;23757393 1308173 Dmrta2 Bp372 (sub_region) 5 93293117 138293117 4 - by one flank marker only 5 90916908 135916908 4 - by one flank marker only 728145 SS.LEW-(D5Rat130-D5Rat108)/Jr 5 89502294 134502294 4 - by one flank marker only 5 84132602 129132602 4 - by one flank marker only 1298087 rat Iddm18 Insulin dependent diabetes mellitus QTL 18 6 1.0E-4 42809 D6Rat184 39052 D6Rat101 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) increased body weight;increased circulating cholesterol level;increased circulating triglyceride level type 1 diabetes mellitus 619685 11327715 6 130448688 144756005 1 - by flanking markers 6 121381065 135964844 1 - by flanking markers 1549799 BB.SHR-(D6Rat184-D6Rat3)/K 6 121224054 135658578 1 - by flanking markers 6 116506292 130245370 1 - by flanking markers 1298088 rat Edpm11 Estrogen-dependent pituitary mass QTL 11 9 2.5 36157 D9Rat31 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) impaired basement membrane formation;pituitary gland hyperplasia Pituitary Neoplasms 629550 11003699 9 1217127 46217127 5 - by peak with adj size 9 1 39963583 5 - by peak with adj size backcross 10008 61109 BN/SsNHsd F344/NHsd 9 2355722 47355722 5 - by peak with adj size 9 1 43718459 5 - by peak with adj size 1298089 rat Scl14 Serum cholesterol level QTL 14 5 5.8 4.0E-4 12.0 33680 D5Mit13 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 737694 14739155 2479;3642 Cyp4a2;Scp2 5 117929881 162929881 5 - by peak with adj size 5 115772027 160772027 5 - by peak with adj size 634365 634366 SS/Hsd SR/Hsd 5 114140832 159140832 5 - by peak with adj size 5 108845856 153845856 5 - by peak with adj size 1298090 rat Bp155 Blood pressure QTL 155 5 3.8 58.5 34206 D5Mgh15 34168 D5Mgh22 11002 D5Mit15 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 731210 14678232 3193;3194 Nppa;Nppb Cm24 (maps to same region);Lanf1 (maps to same region);Strs2 (maps to same region) 5 160953783 171364494 1 - by flanking markers 5 157584492 167844579 1 - by flanking markers 70454 728194 WKY/N SHR/N 5 157212422 167739539 1 - by flanking markers 5 151006154 161165494 1 - by flanking markers 1298524 rat Oia8 Oil induced arthritis QTL 8 4 34174 D4Mgh7 33778 D4Mit21 34473 D4Mgh10 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 629560 12571866 RA20_H (maps to syntenic region) 4 200825021 244267149 2 - by one flank and peak markers 4 136668162 181668162 5 - by peak with adj size 737861 DA.PVG.1AV1-(D4Rat63-D4Rat203) 4 136351734 174694858 2 - by one flank and peak markers 4 138503169 173369699 2 - by one flank and peak markers 1298525 rat Cm1 Cardiac mass QTL 1 7 2.7 62494 D7Uia1 66593 D7Mco1 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight Cardiomegaly;hypertension 69710 9383281 7 108833186 112367543 1 - by flanking markers 7 105412922 108875615 1 - by flanking markers 10040 10041 SR/Jr SS/Jr 7 108889614 112429186 1 - by flanking markers 7 99736187 103146217 1 - by flanking markers 1298526 rat Arunc3 Aerobic running capacity QTL 3 3 2.2 35981 D3Rat56 38346 D3Rat98 35981 D3Rat56 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) decreased aerobic running capacity;increased aerobic running capacity 619535;1547852 12079278;16033863 735225;1305546;1309048;1311721 Serping1;Anapc2;Snapc4;Nmi dominant Arunc2 (interacts with) 3 2612834 38637167 1 - by flanking markers 3 3577905 30254280 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 3 2631421 33477544 1 - by flanking markers 3 8227194 33703538 1 - by flanking markers 1298527 rat Arunc2 Aerobic running capacity QTL 2 16 2.9 37174 D16Rat42 36608 D16Rat48 41324 D16Rat55 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) decreased aerobic running capacity;increased aerobic running capacity 619535;1547852 12079278;16033863 2015;69316;620427;628670;1306769 Acsl1;Irs2;Pdlim3;Ppif;Tm2d2 dominant Arunc3 (interacts with) 16 72850762 79690408 2 - by one flank and peak markers 16 73394189 79850195 2 - by one flank and peak markers 10011 734475 COP/OlaHsd DA/OlaHsd 16 73219638 80115794 2 - by one flank and peak markers 16 68532716 75029966 2 - by one flank and peak markers 1298528 rat Bp169 Blood pressure QTL 169 7 1.0E-4 66604 D7Mco7 39956 D7Rat131 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 69711;629613 11247666;12682779 Bp335 (sub_region);Bp61 (maps to same region);Bpq6_m (maps to syntenic region) 7 115335186 116059683 1 - by flanking markers 7 111882577 112979256 1 - by flanking markers 1299868 SS.SR-(D7Uia1-D7Mco7)/Jr 7 70421228 115421228 4 - by one flank marker only 7 61074194 106074194 4 - by one flank marker only 1298529 rat Arunc1 Aerobic running capacity QTL 1 16 4.0 35280 D16Rat19 39838 D16Rat109 37054 D16Rat17 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) decreased aerobic running capacity;increased aerobic running capacity 619535;1547852 12079278;16033863 2015;2061;3199;69316;620427;628670;1306769 Acsl1;Adrb3;Npy5r;Irs2;Pdlim3;Ppif;Tm2d2 dominant 16 35126908 63570711 1 - by flanking markers 16 35339929 63977788 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 16 35307110 63909364 1 - by flanking markers 16 31951520 60148445 1 - by flanking markers 1300075 rat Glom7 Glomerulus QTL 7 6 5.6 2.0E-7 33987 D6Mit8 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) abnormal renal glomerulus morphology Albuminuria 730279 14638907 6 84871080 129871080 5 - by peak with adj size 6 75061972 120061972 5 - by peak with adj size 731185 731186 MWF/Fub SHR/Fub 6 75449871 120449871 5 - by peak with adj size 6 71201409 116201409 5 - by peak with adj size 1300076 rat Glom8 Glomerulus QTL 8 6 7.0 9.0E-9 36990 D6Rat12 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) abnormal renal glomerulus morphology Albuminuria 730279 14638907 6 100970063 145970063 5 - by peak with adj size 6 91532057 136532057 5 - by peak with adj size 731185 731186 MWF/Fub SHR/Fub 6 91703409 136703409 5 - by peak with adj size 6 86894788 131894788 5 - by peak with adj size 1300107 rat Rf18 Renal function QTL 18 10 3.41 39226 D10Rat86 40488 D10Rat201 34896 D10Rat17 urine output (VT:0003620) timed urine volume (CMO:0000260) abnormal urine homeostasis;polyuria Polyuria;kidney disease 727992 14532335 10 81346666 101432356 1 - by flanking markers 10 82474813 102865929 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 81515116 101758478 1 - by flanking markers 10 78775516 98279596 1 - by flanking markers 1300108 rat Rf8 Renal function QTL 8 1 3.75 40028 D1Rat301 35457 D1Rat90 35457 D1Rat90 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;decreased renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 727992 14532335 Rf6 (interacts with);Rf7 (interacts with) 1 256444932 289137268 1 - by flanking markers 1 234595190 267111153 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 249206242 281795785 1 - by flanking markers 1 228581588 259647894 1 - by flanking markers 1300109 rat Rf13 Renal function QTL 13 4 3.91 35879 D4Rat67 36655 D4Rat70 39414 D4Rat204 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 4 224440904 248343840 2 - by one flank and peak markers 4 161028988 184893756 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 157423126 184226339 2 - by one flank and peak markers 4 157710145 182687754 2 - by one flank and peak markers 1300110 rat Stl7 Serum triglyceride level QTL 7 11 4.64 35483 D11Rat15 10375 D11Mgh1 35955 D11Rat38 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) abnormal circulating creatinine level;increased circulating triglyceride level;increased systemic arterial blood pressure Hypertriglyceridemia 727992 14532335 11 34054821 89808503 1 - by flanking markers 11 29744366 84560241 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 30435339 86714631 1 - by flanking markers 11 29528418 82566702 1 - by flanking markers 1300111 rat Rf12 Renal function QTL 12 3 3.78 39912 D3Rat180 36717 D3Rat17 40016 D3Rat168 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal glomerulus morphology;abnormal renal plasma flow rate;increased systemic arterial blood pressure;kidney inflammation hypertension;kidney disease 727992 14532335 Kidm4 (interacts with);Rf10 (interacts with);Rf11 (maps to same region) 3 69467333 133513825 1 - by flanking markers 3 58764506 121619110 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 62922868 127023997 1 - by flanking markers 3 61017749 121056321 1 - by flanking markers 1300112 rat Bp183 Blood pressure QTL 183 7 3.51 35559 D7Rat13 37774 D7Rat80 37774 D7Rat80 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 7 126904511 141946865 1 - by flanking markers 7 124315012 141301748 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 121654760 145729302 5 - by peak with adj size 7 111182207 135012528 5 - by peak with adj size 1300113 rat Bp176 Blood pressure QTL 176 3 3.9 36584 D3Rat6 40676 D3Rat142 37980 D3Rat114 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal kidney size;increased systemic arterial blood pressure hypertension 727992 14532335 Bp177 (interacts with) 3 158307259 171495734 1 - by flanking markers 3 147990566 159769019 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 153412455 165355668 1 - by flanking markers 3 145956084 157309487 1 - by flanking markers 1300114 rat Srn2 Serum renin concentration QTL 2 14 3.27 36536 D14Rat1 41990 D14Arb16 35965 D14Rat6 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal renin activity kidney disease 727992 14532335 14 4830815 22901310 1 - by flanking markers 14 4895894 22837299 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 4833233 23004027 1 - by flanking markers 14 3813074 21217635 1 - by flanking markers 1300115 rat Hrtrt7 Heart rate QTL 7 5 2.76 36279 D5Rat4 40992 D5Rat148 34216 D5Mgh6 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Bp180 (interacts with);Hrtrt8 (interacts with) 5 53302456 92225914 1 - by flanking markers 5 49767270 89261520 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 48722038 93587756 2 - by one flank and peak markers 5 47869062 90099692 2 - by one flank and peak markers 1300116 rat Hrtrt5 Heart rate QTL 5 4 3.76 38344 D4Rat106 41568 D4Rat200 34174 D4Mgh7 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt6 (interacts with) 4 179959725 215966084 1 - by flanking markers 4 117887605 154283969 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 115372758 150038284 1 - by flanking markers 4 116179486 151161268 1 - by flanking markers 1300117 rat Hrtrt8 Heart rate QTL 8 5 3.49 39686 D5Rat119 36279 D5Rat4 36618 D5Rat2 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased circulating triglyceride level;increased systemic arterial blood pressure Hypertriglyceridemia 727992 14532335 Bp180 (interacts with);Hrtrt7 (interacts with) 5 3239567 53302606 1 - by flanking markers 5 2965857 49767421 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 3251329 48722188 1 - by flanking markers 5 3844018 47869213 1 - by flanking markers 1300118 rat Bp190 Blood pressure QTL 190 15 2.94 34409 D15Mgh9 40516 D15Rat106 40516 D15Rat106 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) increased systemic arterial blood pressure hypertension 727992 14532335 15 93131834 109944957 1 - by flanking markers 15 89569706 106177917 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 89640684 106550657 1 - by flanking markers 15 82262520 98288169 1 - by flanking markers 1300119 rat Bp180 Blood pressure QTL 180 5 3.82 39176 D5Rat103 41798 D5Rat246 39168 D5Rat99 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Hrtrt7 (interacts with);Hrtrt8 (interacts with) 5 154014163 168107673 2 - by one flank and peak markers 5 151039725 164343989 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 150340838 164298744 2 - by one flank and peak markers 5 144358090 157869054 2 - by one flank and peak markers 1300120 rat Kidm7 Kidney mass QTL 7 15 3.55 34409 D15Mgh9 40516 D15Rat106 35497 D15Rat25 kidney mass (VT:0002707) left kidney wet weight to body weight ratio (CMO:0001954) abnormal kidney weight;abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 15 93131834 109944957 1 - by flanking markers 15 89569706 106177917 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 89640684 106550657 1 - by flanking markers 15 82262520 98288169 1 - by flanking markers 1300121 rat Hrtrt1 Heart rate QTL 1 1 3.7 34037 D1Mit1 35166 D1Rat33 41374 D1Rat265 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt2 (maps to same region) 1 67159157 123747809 2 - by one flank and peak markers 1 64744882 116153262 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 66113339 122614963 2 - by one flank and peak markers 1 65789093 115540829 2 - by one flank and peak markers 1300122 rat Wbc1 White blood cell count QTL 1 5 2.75 40992 D5Rat148 38510 D5Rat63 38828 D5Rat90 leukocyte quantity (VT:0000217) total white blood cell count (CMO:0000365) abnormal leukocyte cell number;increased leukocyte cell number Inflammation;heart disease 727992 14532335 5 92225721 149494629 1 - by flanking markers 5 89261341 147065912 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 130531300 145726262 2 - by one flank and peak markers 5 125392826 139989768 2 - by one flank and peak markers 1300123 rat Bp194 Blood pressure QTL 194 17 2.82 35116 D17Rat53 35697 D17Rat16 38348 D17Rat59 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 17 512253 37591626 1 - by flanking markers 17 7696509 41028541 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 519770 36283402 1 - by flanking markers 17 2115149 34551001 1 - by flanking markers 1300124 rat Cm4 Cardiac mass QTL 4 9 3.55 38604 D9Rat101 35819 D9Rat26 40170 D9Rat135 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) abnormal heart size;abnormal renal plasma flow rate;increased systemic arterial blood pressure Cardiomegaly;hypertension 727992 14532335 9 1 44725204 2 - by one flank and peak markers 9 1 37313370 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 9 1 45029794 2 - by one flank and peak markers 9 1 40594091 2 - by one flank and peak markers 1300125 rat Rf26 Renal function QTL 26 18 3.2 34182 D18Mgh3 37568 D18Rat55 39610 D18Rat91 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) decreased urine potassium level kidney disease 727992 14532335 18 53346447 66665061 1 - by flanking markers 18 54856651 69013303 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 54108474 67502122 1 - by flanking markers 18 52539863 65844950 1 - by flanking markers 1300126 rat Bp175 Blood pressure QTL 175 2 3.46 35290 D2Rat60 36241 D2Rat72 34858 D2Rat69 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;kidney inflammation hypertension 727992;10755344 14532335;22912817 Bp174 (maps to same region);Bp389 (maps to same region) 2 248961074 283538297 1 - by flanking markers 2 222939299 256217383 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 229606682 264899009 1 - by flanking markers 2 214226044 247136170 1 - by flanking markers 1300127 rat Srn1 Serum renin concentration QTL 1 7 3.87 36691 D7Rat27 41186 D7Rat139 38794 D7Rat73 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal renin activity kidney disease 727992 14532335 7 35931747 93795816 1 - by flanking markers 7 32004504 89945095 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 35867729 93155402 1 - by flanking markers 7 29409683 84928080 1 - by flanking markers 1300128 rat Rf16 Renal function QTL 16 6 3.89 35963 D6Rat46 35396 D6Rat35 39124 D6Rat62 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased renal plasma flow rate kidney disease 727992 14532335 6 23080221 44141213 1 - by flanking markers 6 13286615 35233017 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 13122958 34367603 1 - by flanking markers 6 5074497 34434305 1 - by flanking markers 1300129 rat Rf25 Renal function QTL 25 17 3.03 35274 D17Rat45 35827 D17Rat52 35687 D17Rat47 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) abnormal circulating creatinine level;abnormal renal filtration rate;decreased creatinine clearance kidney disease 727992 14532335 17 76512693 86907303 1 - by flanking markers 17 82277326 92594341 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 74852630 85183543 1 - by flanking markers 17 71003325 81153923 1 - by flanking markers 1300130 rat Rf20 Renal function QTL 20 11 4.44 35483 D11Rat15 35955 D11Rat38 40546 D11Rat71 kidney glomerulus integrity trait (VT:0010546) kidney glomerulus diameter (CMO:0001166) abnormal renal glomerulus morphology;increased systemic arterial blood pressure;kidney inflammation focal segmental glomerulosclerosis;hypertension 727992 14532335 11 34054821 66314226 1 - by flanking markers 11 29744366 62045696 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 30435339 63186373 1 - by flanking markers 11 29528418 60324829 1 - by flanking markers 1300131 rat Bp193 Blood pressure QTL 193 17 3.3 35258 D17Rat36 35687 D17Rat47 35274 D17Rat45 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 17 68744780 79573336 1 - by flanking markers 17 74663818 85072478 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 67004212 77922655 1 - by flanking markers 17 63640009 73951021 1 - by flanking markers 1300132 rat Bp182 Blood pressure QTL 182 7 3.49 35068 D7Rat32 41186 D7Rat139 38794 D7Rat73 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Bp181 (interacts with) 7 25506703 93795816 1 - by flanking markers 7 21790655 89945095 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 25365633 93155402 1 - by flanking markers 7 19654317 84928080 1 - by flanking markers 1300133 rat Rf24 Renal function QTL 24 16 3.64 40724 D16Rat87 39586 D16Rat76 40724 D16Rat87 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) abnormal circulating creatinine level;abnormal renal filtration rate;increased systemic arterial blood pressure hypertension 727992 14532335 16 4082652 22994297 1 - by flanking markers 16 3464719 22979073 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 16 4136355 23105837 1 - by flanking markers 16 3380150 21361552 1 - by flanking markers 1300134 rat Bp185 Blood pressure QTL 185 9 3.73 34815 D9Rat16 39380 D9Rat108 36908 D9Rat4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 9 66570118 112478017 1 - by flanking markers 9 58516719 103918256 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 9 66757444 112943287 1 - by flanking markers 9 61381434 104821652 1 - by flanking markers 1300135 rat Rf19 Renal function QTL 19 11 3.38 40546 D11Rat71 10375 D11Mgh1 36065 D11Rat6 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) abnormal circulating creatinine level;abnormal renal filtration rate;decreased urine protein level;increased systemic arterial blood pressure hypertension;proteinuria 727992 14532335 11 46280029 89808503 1 - by flanking markers 11 41711171 84560241 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 43090338 86714631 1 - by flanking markers 11 40946188 82566702 1 - by flanking markers 1300136 rat Rf22 Renal function QTL 22 14 3.9 35319 D14Rat16 40140 D14Rat95 40852 D14Rat90 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 727992 14532335 14 43697829 104803539 1 - by flanking markers 14 44934410 101647208 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 43910761 105074364 1 - by flanking markers 14 42262529 95023211 1 - by flanking markers 1300137 rat Bp186 Blood pressure QTL 186 10 3.57 34896 D10Rat17 35254 D10Rat2 35254 D10Rat2 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 10 93641751 110568670 1 - by flanking markers 10 95066219 110718848 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 93886117 110992275 1 - by flanking markers 10 90627439 107057807 1 - by flanking markers 1300138 rat Hrtrt9 Heart rate QTL 9 7 4.72 36691 D7Rat27 38794 D7Rat73 42215 D7Arb16 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;abnormal urine homeostasis;increased systemic arterial blood pressure hypertension 727992 14532335 7 35931747 61045154 1 - by flanking markers 7 32004504 57326584 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 35867729 61047824 1 - by flanking markers 7 29409683 53612950 1 - by flanking markers 1300139 rat Hrtrt6 Heart rate QTL 6 4 2.85 34238 D4Mgh2 38344 D4Rat106 41200 D4Rat169 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt5 (interacts with) 4 37552221 179959894 1 - by flanking markers 4 36611842 117887968 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 37703272 115372927 1 - by flanking markers 4 39524264 116179656 1 - by flanking markers 1300140 rat Srn3 Serum renin concentration QTL 3 14 3.19 35965 D14Rat6 34965 D14Rat10 36520 D14Rat7 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal renin activity kidney disease 727992 14532335 14 16262980 32957654 1 - by flanking markers 14 16432517 33157602 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 16336988 33163485 1 - by flanking markers 14 14875168 30883947 1 - by flanking markers 1300141 rat Bp178 Blood pressure QTL 178 4 36504 D4Rat2 34238 D4Mgh2 38908 D4Rat126 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 Bp179 (maps to same region) 4 6590796 37552486 1 - by flanking markers 4 5437007 36612108 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 6572939 37703537 1 - by flanking markers 4 10024901 39524530 1 - by flanking markers 1300142 rat Bp191 Blood pressure QTL 191 15 3.14 40434 D15Rat114 38696 D15Rat75 40434 D15Rat114 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 15 1 16828048 4 - by one flank marker only 15 1 14324156 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 1 12800829 4 - by one flank marker only 1300143 rat Rf14 Renal function QTL 14 6 2.92 35396 D6Rat35 41416 D6Rat126 36586 D6Rat26 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased creatinine clearance kidney disease 727992 14532335 6 44141046 90014325 1 - by flanking markers 6 35232849 80102311 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 34367436 80490628 1 - by flanking markers 6 34434137 77102317 1 - by flanking markers 1300144 rat Rf23 Renal function QTL 23 15 3.61 34910 D15Rat14 40516 D15Rat106 34409 D15Mgh9 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 727992 14532335 15 48493430 109944957 1 - by flanking markers 15 45870097 106177917 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 43097470 106550657 1 - by flanking markers 15 40631268 98288169 1 - by flanking markers 1300145 rat Rf7 Renal function QTL 7 1 2.96 37556 D1Rat130 35909 D1Rat74 40230 D1Rat295 urine creatinine amount (VT:0010540) urine creatinine level (CMO:0000125) abnormal renal filtration rate;decreased creatinine clearance kidney disease 727992 14532335 Rf8 (interacts with) 1 208178542 248763894 1 - by flanking markers 1 189900686 227005733 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 201146802 241482368 1 - by flanking markers 1 185145134 221264292 1 - by flanking markers 1300146 rat Rf17 Renal function QTL 17 8 2.9 35663 D8Rat51 41122 D8Rat159 36673 D8Rat49 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased renal plasma flow rate kidney disease 727992 14532335 8 30947236 75947236 4 - by one flank marker only 8 29559446 74559446 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 30918112 75918112 4 - by one flank marker only 8 28242912 73242912 4 - by one flank marker only 1300147 rat Bp187 Blood pressure QTL 187 11 3.67 35957 D11Rat22 41256 D11Rat61 35483 D11Rat15 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 11 11251738 75797949 1 - by flanking markers 11 9053659 50435443 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 11 1 72720192 2 - by one flank and peak markers 11 1 69446234 2 - by one flank and peak markers 1300148 rat Bp192 Blood pressure QTL 192 17 3.47 35697 D17Rat16 35687 D17Rat47 35258 D17Rat36 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 17 37591469 79573336 1 - by flanking markers 17 41028379 85072478 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 36283245 77922655 1 - by flanking markers 17 34550843 73951021 1 - by flanking markers 1300149 rat Cm6 Cardiac mass QTL 6 7 4.09 41130 D7Rat136 42215 D7Arb16 35068 D7Rat32 heart mass (VT:0007028) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart size;abnormal heart ventricle morphology;abnormal hematocrit;abnormal leukocyte cell number Cardiomegaly 727992 14532335 7 51264916 111529342 1 - by flanking markers 7 47145774 107950815 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 51252005 111589099 1 - by flanking markers 7 43747099 102228765 1 - by flanking markers 1300150 rat Cm3 Cardiac mass QTL 3 8 3.97 41454 D8Rat149 36161 D8Rat36 41122 D8Rat159 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) abnormal heart size Cardiomegaly 727992 14532335 8 57006953 58297648 1 - by flanking markers 8 57308742 58692901 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 58425679 59716199 1 - by flanking markers 8 54237814 55523877 1 - by flanking markers 1300151 rat Bp181 Blood pressure QTL 181 7 3.36 38794 D7Rat73 40966 D7Rat133 41186 D7Rat139 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 Bp182 (interacts with) 7 61044919 113165396 1 - by flanking markers 7 57326196 109727159 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 61047589 113228378 1 - by flanking markers 7 53612714 103945643 1 - by flanking markers 1300152 rat Bp195 Blood pressure QTL 195 20 3.46 34749 D20UW1 34908 D20Rat2 34749 D20UW1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 727992 14532335 20 6935868 12079657 1 - by flanking markers 20 3660638 9534510 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 20 4855468 9899946 1 - by flanking markers 20 3621649 9243559 1 - by flanking markers 1300153 rat Bp171 Blood pressure QTL 171 1 3.37 41374 D1Rat265 37970 D1Rat210 37930 D1Rat183 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 Bp170 (interacts with);Bp172 (maps to same region);Bp173 (interacts with) 1 95453405 159388156 1 - by flanking markers 1 90448902 145865373 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 94364073 153076991 1 - by flanking markers 1 90664883 143200202 1 - by flanking markers 1300154 rat Bp189 Blood pressure QTL 189 14 3.04 34965 D14Rat10 40852 D14Rat90 36287 D14Rat12 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 14 32957485 73407773 1 - by flanking markers 14 33157432 73956701 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 33163316 73391571 1 - by flanking markers 14 30883777 68757901 1 - by flanking markers 1300155 rat Bp174 Blood pressure QTL 174 2 4.09 37018 D2Rat14 41400 D2Rat216 40672 D2Rat202 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) abnormal urine homeostasis;increased systemic arterial blood pressure hypertension;proteinuria 727992 14532335 Bp175 (maps to same region) 2 61825950 79917090 2 - by one flank and peak markers 2 29321080 74321080 5 - by peak with adj size 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 42776916 62238534 2 - by one flank and peak markers 2 42804607 60653831 2 - by one flank and peak markers 1300156 rat Bp179 Blood pressure QTL 179 4 2.85 35847 D4Rat12 34238 D4Mgh2 38908 D4Rat126 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 Bp178 (maps to same region) 4 36467227 37552486 1 - by flanking markers 4 15744638 36612108 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 36615599 37703537 1 - by flanking markers 4 38465774 39524530 1 - by flanking markers 1300157 rat Rf21 Renal function QTL 21 12 4.4 35501 D12Rat2 37830 D12Rat36 34729 D12Mgh5 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) decreased renal plasma flow rate hypertension;kidney disease 727992 14532335 12 13827920 39392915 1 - by flanking markers 12 9628802 33216334 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 11764995 37522089 1 - by flanking markers 12 9318216 32103380 1 - by flanking markers 1300158 rat Bp173 Blood pressure QTL 173 1 3.48 35166 D1Rat33 37556 D1Rat130 38878 D1Rat139 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Bp170 (interacts with);Bp171 (interacts with);Bp172 (interacts with) 1 123747670 208178693 1 - by flanking markers 1 115946374 189900838 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 122614824 201146953 1 - by flanking markers 1 115540693 185145286 1 - by flanking markers 1300159 rat Kidm4 Kidney mass QTL 4 3 3.83 36717 D3Rat17 40676 D3Rat142 36584 D3Rat6 kidney mass (VT:0002707) right kidney wet weight to body weight ratio (CMO:0001953) abnormal kidney size;abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 Rf10 (interacts with);Rf12 (interacts with) 3 133062559 171495734 1 - by flanking markers 3 121618954 159769019 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 126575595 165355668 1 - by flanking markers 3 121056165 157309487 1 - by flanking markers 1300160 rat Hrtrt3 Heart rate QTL 3 2 3.62 40242 D2Rat194 40672 D2Rat202 37018 D2Rat14 heart pumping trait (VT:2000009) absolute change in heart rate (CMO:0000534) abnormal heart rate;increased heart rate;increased systemic arterial blood pressure heart disease;hypertension 727992 14532335 2 47825961 70871600 1 - by flanking markers 2 29237360 51821161 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 28727867 52507805 1 - by flanking markers 2 29971593 51729300 1 - by flanking markers 1300161 rat Rf10 Renal function QTL 10 3 3.57 41322 D3Rat137 38456 D3Rat77 36745 D3Rat1 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 Kidm4 (interacts with);Rf11 (interacts with);Rf12 (interacts with) 3 176504241 183740530 2 - by one flank and peak markers 3 163335007 171063335 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 170428815 177699992 2 - by one flank and peak markers 3 161192952 169034231 2 - by one flank and peak markers 1300162 rat Bp188 Blood pressure QTL 188 12 3.19 37830 D12Rat36 35431 D12Rat22 35431 D12Rat22 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 727992 14532335 12 39392710 53694105 1 - by flanking markers 12 33216127 46043557 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 37521884 51955754 1 - by flanking markers 12 32103174 45899022 1 - by flanking markers 1300163 rat Cardf1 Cardiac cell morphology QTL 1 13 4.18 36922 D13Rat4 38240 D13Rat91 36922 D13Rat4 aorta morphology trait (VT:0000272) artery lesion measurement (CMO:0000975) abnormal aorta morphology aortic disease 727992;70849 14532335;11721057 13 19680631 55853202 1 - by flanking markers 13 1265159 46912163 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 14441582 50799665 1 - by flanking markers 13 11929449 45417941 1 - by flanking markers 1300164 rat Rf15 Renal function QTL 15 6 3.12 35963 D6Rat46 36586 D6Rat26 35653 D6Rat42 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 6 23080221 67112973 1 - by flanking markers 6 13286615 56714969 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 13122958 57516539 1 - by flanking markers 6 5074497 54641141 1 - by flanking markers 1300165 rat Rf9 Renal function QTL 9 2 3.28 37456 D2Rat147 34461 D2Mgh12 36213 D2Rat40 kidney glomerulus integrity trait (VT:0010546) index of glomerular damage (CMO:0001135) abnormal renal glomerulus morphology;increased systemic arterial blood pressure;kidney inflammation focal segmental glomerulosclerosis;hypertension 727992 14532335 2 158383046 235592880 1 - by flanking markers 2 138700979 210636169 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 138901276 217498710 1 - by flanking markers 2 133914684 202447032 1 - by flanking markers 1300166 rat Kidm6 Kidney mass QTL 6 13 3.93 37844 D13Rat85 33644 D13Mit4 33644 D13Mit4 kidney mass (VT:0002707) single kidney wet weight to body weight ratio (CMO:0000622) abnormal kidney weight kidney disease 727992 14532335 13 79488981 97381801 1 - by flanking markers 13 72141292 90551272 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 74568378 92916783 1 - by flanking markers 13 69060519 86800898 1 - by flanking markers 1300167 rat Hrtrt2 Heart rate QTL 2 1 4.35 36568 D1Rat4 34037 D1Mit1 38782 D1Rat136 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 Hrtrt1 (maps to same region) 1 12920106 76895298 2 - by one flank and peak markers 1 11859997 63434427 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 11314489 75844121 2 - by one flank and peak markers 1 11481312 75088344 2 - by one flank and peak markers 1300168 rat Bp170 Blood pressure QTL 170 1 2.76 40230 D1Rat295 40028 D1Rat301 35909 D1Rat74 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 727992 14532335 Bp171 (interacts with);Bp172 (maps to same region);Bp173 (interacts with) 1 234174587 262883789 1 - by flanking markers 1 213554130 234595366 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 227107736 249206417 1 - by flanking markers 1 207702246 228581766 1 - by flanking markers 1300169 rat Bp177 Blood pressure QTL 177 3 2.96 38346 D3Rat98 39912 D3Rat180 41780 D3Rat227 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 Bp176 (interacts with) 3 38636977 69467440 1 - by flanking markers 3 30253942 58764827 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 33477354 62922975 1 - by flanking markers 3 33703347 61017857 1 - by flanking markers 1300170 rat Rf6 Renal function QTL 6 1 3.14 37610 D1Rat167 36568 D1Rat4 37610 D1Rat167 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;decreased renal plasma flow rate kidney disease 727992 14532335 Rf8 (interacts with) 1 5511572 12920275 1 - by flanking markers 1 4404877 11860328 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 3839159 11314658 1 - by flanking markers 1 4162807 11481482 1 - by flanking markers 1300171 rat Bp184 Blood pressure QTL 184 8 3.66 38670 D8Rat114 36327 D8Rat2 34180 D8Mgh1 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased systemic arterial blood pressure hypertension 727992 14532335 8 80428299 126404948 1 - by flanking markers 8 74281610 123415406 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 76103982 127182642 1 - by flanking markers 8 70513503 118219066 1 - by flanking markers 1300172 rat Bp172 Blood pressure QTL 172 1 3.56 37598 D1Rat176 41374 D1Rat265 34037 D1Mit1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 727992 14532335 Bp170 (maps to same region);Bp171 (maps to same region);Bp173 (interacts with) 1 36777313 95453561 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 35377508 94364229 1 - by flanking markers 1 32737273 90665040 1 - by flanking markers 1300173 rat Rf11 Renal function QTL 11 3 3.38 36717 D3Rat17 36584 D3Rat6 36797 D3Rat11 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate;increased systemic arterial blood pressure hypertension 727992 14532335 Rf10 (interacts with);Rf12 (maps to same region) 3 133062559 158307423 1 - by flanking markers 3 121618954 147990731 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 126575595 153412619 1 - by flanking markers 3 121056165 145956249 1 - by flanking markers 1300174 rat Bw15 Body weight QTL 15 12 2.93 40394 D12Rat89 35501 D12Rat2 40394 D12Rat89 body mass (VT:0001259) body weight loss (CMO:0001399) abnormal body weight 727992;2312611 14532335;19697080 Bw88 (maps to same region) 12 3966881 13828088 1 - by flanking markers 12 2957061 9628971 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 1 11765163 4 - by one flank marker only 12 1 9318387 4 - by one flank marker only 1300175 rat Cm5 Cardiac mass QTL 5 12 3.78 34729 D12Mgh5 35431 D12Rat22 37830 D12Rat36 heart mass (VT:0007028) heart left ventricle weight to body weight ratio (CMO:0000530) abnormal heart size;abnormal renal plasma flow rate;increased systemic arterial blood pressure Cardiomegaly 727992 14532335 12 33647399 53694105 1 - by flanking markers 12 29130180 46043557 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 31723565 51955754 1 - by flanking markers 12 28064433 45899022 1 - by flanking markers 1300176 rat Hrtrt10 Heart rate QTL 10 7 3.19 35382 D7Rat36 34880 D7Rat31 35382 D7Rat36 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased systemic arterial blood pressure hypertension 727992 14532335 7 2632014 32338830 1 - by flanking markers 7 1526177 28488710 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 2653138 32258115 1 - by flanking markers 7 664270 26029351 1 - by flanking markers 1300177 rat Cm2 Cardiac mass QTL 2 8 3.65 41122 D8Rat159 36003 D8Rat14 36809 D8Rat23 heart mass (VT:0007028) heart weight (CMO:0000017) abnormal heart rate;abnormal heart size;increased systemic arterial blood pressure Cardiomegaly;hypertension 727992 14532335 8 58965714 107492076 2 - by one flank and peak markers 8 58135371 104697495 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 59234112 108068306 2 - by one flank and peak markers 8 54259986 100382532 2 - by one flank and peak markers 1300178 rat Hrtrt4 Heart rate QTL 4 3 3.74 41780 D3Rat227 40016 D3Rat168 39912 D3Rat180 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;increased heart rate heart disease 727992 14532335 3 50522686 101095668 1 - by flanking markers 3 41054012 89859652 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 45406058 94467785 1 - by flanking markers 3 43827364 90905114 1 - by flanking markers 1300179 rat Kidm5 Kidney mass QTL 5 7 3.51 42215 D7Arb16 35559 D7Rat13 40966 D7Rat133 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight kidney disease 727992 14532335 7 51264830 126904662 1 - by flanking markers 7 47145687 124315164 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 51251919 145729302 2 - by one flank and peak markers 7 43747012 135012528 2 - by one flank and peak markers 1300180 rat Bw14 Body weight QTL 14 9 3.776 40738 D9Rat130 34815 D9Rat16 35819 D9Rat26 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 727992 14532335 9 26333329 66570294 1 - by flanking markers 9 20102034 58516896 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 9 27486036 66757620 1 - by flanking markers 9 23754024 61381613 1 - by flanking markers 1302404 rat Cia27 Collagen induced arthritis QTL 27 10 2.6 0.0045 10642 D10Mit12 34128 D10Mgh1 44839 D10Wox7 joint integrity trait (VT:0010548) experimental arthritis severity measurement (CMO:0001459) joint inflammation;joint swelling Experimental Arthritis 1302414;61063;1600534;2306769;2307198 9870869;16691185;18540828;19299744 Ean3 (maps to same region) 10 94240320 109962316 2 - by one flank and peak markers 10 95695048 110718848 2 - by one flank and peak markers 1302416 ACI.DA-(D10Rat2-D10Rat19)/Arb 10 79927661 112626471 5 - by peak with adj size 10 76452683 107211142 5 - by peak with adj size 1302786 rat Kidm8 Kidney mass QTL 8 5 28.15 33678 D5Mit10 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) enlarged kidney;increased blood urea nitrogen level polycystic kidney disease;uremia 629573 9097967 3334 Anks6 dominant 5 38938687 83938687 5 - by peak with adj size 5 35474610 80474610 5 - by peak with adj size 68118 728168 PKD WOK 5 34402409 79402409 5 - by peak with adj size 5 33215665 78215665 5 - by peak with adj size 1302787 rat Stl25 Serum triglyceride level QTL 25 1 2.7 0.0073 36592 D1Rat64 36757 D1Rat71 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating cholesterol level;increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 1 204172176 237556978 1 - by flanking markers 1 184857716 216663271 1 - by flanking markers intercross 60999 1302795 LEW HTG 1 197187728 230420772 1 - by flanking markers 1 180359209 210702199 1 - by flanking markers 1302788 rat Scl19 Serum cholesterol QTL 19 1 4.6 0.001 38792 D1Rat137 36432 D1Rat35 36765 D1Rat27 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia 1299960 14709677 1 95325941 131959064 1 - by flanking markers 1 90306033 124749065 1 - by flanking markers intercross 60999 1302795 LEW HTG 1 94225372 130917265 1 - by flanking markers 1 90532338 123479925 1 - by flanking markers 1302789 rat Stl26 Serum triglyceride level QTL 26 2 3.1 0.0035 35693 D2Rat55 37424 D2Rat111 35915 D2Rat61 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 2 1 237043265 2 - by one flank and peak markers 2 212168913 242131387 2 - by one flank and peak markers intercross 60999 1302795 LEW HTG 2 218957047 240977220 1 - by flanking markers 1302790 rat Scl20 Serum cholesterol level QTL 20 5 6.4 1.0E-4 41318 D5Rat147 36237 D5Rat49 38338 D5Rat108 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) decreased circulating cholesterol level 1299960;2312642 14709677;19584880 Scl64 (maps to same region) 5 89056339 176978545 1 - by flanking markers 5 86116638 172913795 1 - by flanking markers intercross 60999 1302795 LEW HTG 5 84963058 173504662 1 - by flanking markers 5 82394392 166664054 1 - by flanking markers 1302791 rat Stl29 Serum triglyceride level QTL 29 13 3.3 0.0011 45079 D13Wox8 33644 D13Mit4 37088 D13Rat34 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level;increased circulating triglyceride level Hypercholesterolemia;Hypertriglyceridemia;Metabolic Syndrome 1299960 14709677 13 95174535 97381801 1 - by flanking markers 13 88260176 90551272 1 - by flanking markers 60999 1302795 LEW HTG 13 90652874 92916783 1 - by flanking markers 13 84730788 86800898 1 - by flanking markers 1302792 rat Scl21 Serum cholesterol level QTL 21 12 3.8 0.0011 35923 D12Rat12 38952 D12Rat40 34898 D12Rat20 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) decreased circulating cholesterol level 1299960 14709677 12 10898188 54450796 2 - by one flank and peak markers 12 7754826 25802539 1 - by flanking markers 60999 1302795 LEW HTG 12 8954593 27911196 1 - by flanking markers 12 7196730 46669029 2 - by one flank and peak markers 1302793 rat Bw16 Body weight QTL 16 2 5.0 1.0E-4 34461 D2Mgh12 36213 D2Rat40 34234 D2Mgh9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 2 189197988 235592715 1 - by flanking markers 2 163154358 210636008 1 - by flanking markers intercross 60999 1302795 LEW HTG 2 169852800 217498545 1 - by flanking markers 2 157142209 202446871 1 - by flanking markers 1302794 rat Stl27 Serum triglyceride level QTL 27 2 4.4 1.0E-4 38576 D2Rat182 34005 D2Mit8 39512 D2Rat210 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypercholesterolemia 1299960 14709677 2 43009380 169047413 1 - by flanking markers 2 24474447 148790758 1 - by flanking markers intercross 60999 1302795 LEW HTG 2 23837491 149614623 1 - by flanking markers 2 25413423 143657569 1 - by flanking markers 1331720 rat Rf43 Renal function QTL 43 17 2.881 34276 D17Mgh2 35302 D17Rat9 38348 D17Rat59 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) increased renal vascular resistance kidney disease;renal hypertension 70849 11721057 Hrtrt15 (maps to same region) 17 17801320 24686091 1 - by flanking markers 17 21286331 28903238 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 15743755 22711729 1 - by flanking markers 17 15330613 23017269 1 - by flanking markers 1331721 rat Bp210 Blood pressure QTL 210 5 3.413 34443 D5Mgh8 35823 D5Rat50 41492 D5Rat178 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) increased heart rate;increased systemic arterial blood pressure heart disease;hypertension 70849 11721057 5 152731895 177161806 1 - by flanking markers 5 149757277 173096209 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 149029982 173687766 1 - by flanking markers 5 143069996 166846814 1 - by flanking markers 1331722 rat Thshl1 Thyroid stimulating hormone level QTL 1 6 11.7 1.0E-4 35659 D6Rat18 40144 D6Rat119 38634 D6Rat103 blood thyroid-stimulating hormone amount (VT:0005119) serum thyroid stimulating hormone level (CMO:0001248) increased circulating thyroid-stimulating hormone level thyroid gland disease 1302891;10053640 15514085;21029000 3911;68418;68420 Tshr;Dio2;Dio3 Srcrt6 (maps to same region) 6 103168026 120420482 1 - by flanking markers 6 93373975 111239430 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 6 93706176 111134673 1 - by flanking markers 6 89762877 106752806 1 - by flanking markers 1331723 rat Bw25 Body weight QTL 25 7 3.348 35841 D7Rat19 33969 D7Mit4 40784 D7Rat135 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 70849 11721057 Kidm9 (maps to same region) 7 102486192 104437717 1 - by flanking markers 7 98568413 100273797 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 101918330 103867802 1 - by flanking markers 7 93242123 94811326 1 - by flanking markers 1331724 rat Bp223 Blood pressure QTL 223 15 3.53715 34222 D15Mgh8 34160 D15Mgh5 34409 D15Mgh9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849 11721057 Rf42 (maps to same region) 15 84794264 106602195 1 - by flanking markers 15 80361961 102741337 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 81255292 103165069 1 - by flanking markers 15 73690518 95018228 1 - by flanking markers 1331725 rat Bp212 Blood pressure QTL 212 6 3.52475 33987 D6Mit8 33889 D6Mit16 40438 D6Rat163 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp211 (maps to same region);Bp213 (maps to same region) 6 107370981 143011457 1 - by flanking markers 6 97561873 134379784 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 97949772 133849286 1 - by flanking markers 6 93701310 128713626 1 - by flanking markers 1331726 rat Bp208 Blood pressure QTL 208 3 3.129 33810 D3Mit2 34178 D3Mgh23 34304 D3Mgh18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased renal plasma flow rate;increased systemic arterial blood pressure hypertension;kidney disease 70849 11721057 Bp207 (maps to same region) 3 154751509 177528867 1 - by flanking markers 3 143214619 164269487 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 148348517 171467264 1 - by flanking markers 3 141339013 162184794 1 - by flanking markers 1331727 rat Bp237 Blood pressure QTL 237 18 3.053 10689 D18Mit5 34043 D18Mit16 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp238 (maps to same region) 18 32348154 63072413 1 - by flanking markers 18 32458819 64900201 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 63897621 1 - by flanking markers 18 31359408 61698465 1 - by flanking markers 1331728 rat Bp214 Blood pressure QTL 214 7 2.825 33648 D7Mit5 33729 D7Mit10 40784 D7Rat135 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp215 (maps to same region);Bp216 (maps to same region) 7 88393619 134514043 2 - by one flank and peak markers 7 85089895 130953311 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 88365265 134673427 2 - by one flank and peak markers 7 80221299 124373579 2 - by one flank and peak markers 1331729 rat Rf42 Renal function QTL 42 15 3.071 33713 D15Mit3 34222 D15Mgh8 34619 D15Mgh11 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) decreased renal plasma flow rate;increased renal vascular resistance kidney disease;renal hypertension 70849 11721057 Bp223 (maps to same region) 15 22070681 84794402 1 - by flanking markers 15 19348148 80362100 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 15 18093208 81255430 1 - by flanking markers 15 17362897 73690657 1 - by flanking markers 1331730 rat Scl27 Serum cholesterol level QTL 27 18 3.826 37738 D18Rat57 33884 D18Mit8 33884 D18Mit8 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating HDL cholesterol level familial hyperlipidemia 70849 11721057 Rf44 (maps to same region);Scl28 (maps to same region) 18 53100479 61177004 1 - by flanking markers 18 54605732 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 53861252 61985812 1 - by flanking markers 18 52292875 59796643 1 - by flanking markers 1331731 rat Bp216 Blood pressure QTL 216 7 2.851 40784 D7Rat135 33780 D7Mit1 33729 D7Mit10 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp214 (maps to same region);Bp215 (maps to same region) 7 111453751 141760897 1 - by flanking markers 7 108021523 141116504 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 111519266 143965591 1 - by flanking markers 7 102297359 133492884 1 - by flanking markers 1331732 rat Srn4 Serum renin concentration QTL 4 1 4.467 34037 D1Mit1 10337 D1Mgh5 33931 D1Mit10 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) increased circulating renin level kidney disease 70849 11721057 Rf27 (maps to same region);Rf28 (maps to same region);Rf29 (maps to same region) 1 36630109 80946315 2 - by one flank and peak markers 1 33134446 78134446 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 36033165 79689689 2 - by one flank and peak markers 1 35239598 78430678 2 - by one flank and peak markers 1331733 rat Bp233 Blood pressure QTL 233 18 3.97196 34550 D18Mgh9 36123 D18Rat9 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 25675732 71374137 1 - by flanking markers 18 25620884 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 25961026 81761656 2 - by one flank and peak markers 18 24796977 79788953 2 - by one flank and peak markers 1331734 rat Bp204 Blood pressure QTL 204 2 3.61192 10582 D2Mit12 35064 D2Rat64 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 201404917 258546510 1 - by flanking markers 2 174730375 232307864 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 181990297 240020001 1 - by flanking markers 2 168358098 223265385 1 - by flanking markers 1331735 rat Rf44 Renal function QTL 44 18 2.981 34092 D18Mgh8 10689 D18Mit5 34550 D18Mgh9 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 70849 11721057 Scl27 (maps to same region);Scl28 (maps to same region) 18 19003327 32348275 2 - by one flank and peak markers 18 15852436 32458940 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 19251717 32670473 2 - by one flank and peak markers 18 18234564 31359530 2 - by one flank and peak markers 1331736 rat Bp227 Blood pressure QTL 227 18 2.791 36914 D18Rat18 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 47463943 61177004 1 - by flanking markers 18 48759354 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 48248877 61985812 1 - by flanking markers 18 46718763 59796643 1 - by flanking markers 1331737 rat Uae29 Urinary albumin excretion QTL 29 19 5.5 41262 D19Rat57 40904 D19Rat86 35881 D19Rat11 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) increased urine protein level Albuminuria;proteinuria 1300043 15161966 19 17616412 70892142 2 - by one flank and peak markers 19 5975093 57235101 2 - by one flank and peak markers 631695 631696 SS/JrRkb SHR/FubRkb 19 6506761 60220581 2 - by one flank and peak markers 19 4096155 55283277 2 - by one flank and peak markers 1331738 rat Bp209 Blood pressure QTL 209 4 2.979 34174 D4Mgh7 34477 D4Mgh12 34477 D4Mgh12 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Hrtrt13 (maps to same region) 4 200825021 244849512 1 - by flanking markers 4 161454762 187126005 5 - by peak with adj size 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 136351734 180689124 1 - by flanking markers 4 138503169 179293946 1 - by flanking markers 1331739 rat Hrtrt14 Heart rate QTL 14 12 3.56232 35501 D12Rat2 34031 D12Mit7 37478 D12Rat43 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate;increased heart rate variability cardiovascular system disease;hypertension 70849 11721057 Bp218 (maps to same region);Bp219 (maps to same region);Rf41 (maps to same region);Wbc2 (maps to same region) 12 13827920 16511686 2 - by one flank and peak markers 12 9628802 17773949 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 11764995 14489679 2 - by one flank and peak markers 12 9318216 12829686 2 - by one flank and peak markers 1331740 rat Bw26 Body weight QTL 26 14 3.028 36536 D14Rat1 38932 D14Rat36 10135 D14Wox11 body mass (VT:0001259) body weight (CMO:0000012) heart left ventricle hypertrophy;increased body weight;increased systemic arterial diastolic blood pressure heart disease;hypertension;obesity 70849 11721057 14 4830815 32833594 1 - by flanking markers 14 4895894 33040140 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 14 4833233 33040042 1 - by flanking markers 14 3813074 30767156 1 - by flanking markers 1331741 rat Bp232 Blood pressure QTL 232 18 3.59112 34340 D18Mgh7 37104 D18Rat1 37738 D18Rat57 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 20092556 86108580 2 - by one flank and peak markers 18 22353754 86857890 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 22603736 87074531 1 - by flanking markers 18 21372893 83213037 2 - by one flank and peak markers 1331742 rat Bp228 Blood pressure QTL 228 18 3.88752 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331743 rat Uae28 Urinary albumin excretion QTL 28 6 4.5 35911 D6Rat33 38006 D6Rat69 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) albuminuria;increased urine protein level Albuminuria;proteinuria 1300043 15161966 6 1 51646896 2 - by one flank and peak markers 6 1 28765971 5 - by peak with adj size 631695 631696 SS/JrRkb SHR/FubRkb 6 1 41917988 2 - by one flank and peak markers 6 1 34235784 5 - by peak with adj size 1331744 rat Bp217 Blood pressure QTL 217 8 3.398 33559 D8Mit5 33957 D8Mit16 33858 D8Mit4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure;increased urine protein level hypertension;proteinuria 70849 11721057 Cm30 (maps to same region) 8 33603024 62633993 1 - by flanking markers 8 32203394 61853629 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 33558660 62857995 1 - by flanking markers 8 30848154 58482492 1 - by flanking markers 1331745 rat Bp203 Blood pressure QTL 203 2 4.377 33727 D2Mit14 34495 D2Mgh29 34461 D2Mgh12 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 74641110 224018348 1 - by flanking markers 2 197256223 227310008 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 204585642 235290110 1 - by flanking markers 2 189599258 218414891 1 - by flanking markers 1331746 rat Kidm9 Kidney mass QTL 9 7 3.934 33648 D7Mit5 33755 D7Mit13 33557 D7Mit14 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) enlarged kidney kidney disease 70849 11721057 Bw25 (maps to same region);Kidm10 (maps to same region) 7 88393619 121978492 1 - by flanking markers 7 85089895 119050197 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 88365265 121986709 1 - by flanking markers 7 80221299 112308525 1 - by flanking markers 1331747 rat Hrtrt16 Heart rate QTL 16 20 3.163 34290 D18Mgh4 33997 D20Mit1 33997 D20Mit1 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 70849 11721057 20 28346715 57791882 5 - by peak with adj size 20 25673311 55268282 5 - by peak with adj size 10008 61499 BN/SsNHsd SS/JrHsdMcwi 20 26712323 56205956 5 - by peak with adj size 20 25209734 54435887 5 - by peak with adj size 1331748 rat Bp215 Blood pressure QTL 215 7 4.043 33755 D7Mit13 33780 D7Mit1 33729 D7Mit10 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp214 (maps to same region);Bp216 (maps to same region) 7 121978222 141760897 1 - by flanking markers 7 119049926 141116504 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 121986439 143965591 1 - by flanking markers 7 112308254 133492884 1 - by flanking markers 1331749 rat Hrtrt11 Heart rate QTL 11 1 2.973 11439 D1Mit30 33878 D1Mit27 34381 D1Mgh7 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 70849 11721057 Bp199 (maps to same region);Bp200 (maps to same region);Bp201 (maps to same region) 1 101048742 223075141 1 - by flanking markers 1 94473940 203303100 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 216213510 1 - by flanking markers 1 94494440 198211706 1 - by flanking markers 1331750 rat Bp220 Blood pressure QTL 220 13 2.98 34351 D13Mgh4 34483 D13Mgh9 11376 D13Mgh18 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849;1298024 11721057;11071381 BP19_H (maps to syntenic region);Bp221 (maps to same region) 13 47416073 92416073 4 - by one flank marker only 13 38489801 83489801 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 42310744 87310744 4 - by one flank marker only 13 37415584 82415584 4 - by one flank marker only 1331751 rat Bp199 Blood pressure QTL 199 1 3.60022 11439 D1Mit30 10951 D1Mit13 33959 D1Mit3 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp200 (maps to same region);Bp201 (maps to same region);Hrtrt11 (maps to same region) 1 101048742 205649793 1 - by flanking markers 1 94473940 186472032 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 198656062 1 - by flanking markers 1 94494440 181830018 1 - by flanking markers 1331752 rat Bw27 Body weight QTL 27 18 2.963 37738 D18Rat57 34182 D18Mgh3 33884 D18Mit8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 70849 11721057 Scl28 (maps to same region) 18 53100479 66665205 1 - by flanking markers 18 54605732 69013448 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 53861252 67502266 1 - by flanking markers 18 52292875 65845095 1 - by flanking markers 1331753 rat Bp231 Blood pressure QTL 231 18 3.643 11461 D18Mit1 37738 D18Rat57 33606 D18Mit3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 15314027 53100658 1 - by flanking markers 18 12406975 54605912 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 15539427 53861431 1 - by flanking markers 18 11944299 52293055 1 - by flanking markers 1331754 rat Bp230 Blood pressure QTL 230 18 4.61609 34092 D18Mgh8 36123 D18Rat9 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 34826999 71374137 2 - by one flank and peak markers 18 15852436 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 31361341 76361341 5 - by peak with adj size 18 29792965 74792965 5 - by peak with adj size 1331755 rat Bp219 Blood pressure QTL 219 12 3.041 37478 D12Rat43 34729 D12Mgh5 34031 D12Mit7 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp218 (maps to same region);Hrtrt14 (maps to same region);Kidm11 (maps to same region);Rf41 (maps to same region);Wbc2 (maps to same region) 12 15169677 33647522 1 - by flanking markers 12 11416955 29130304 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 13127211 31723688 1 - by flanking markers 12 11073825 28064557 1 - by flanking markers 1331756 rat Rf34 Renal function QTL 34 5 4.16275 34226 D5Mgh1 33981 D5Mit4 34212 D5Mgh5 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) decreased renal plasma flow rate kidney disease 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 742398 97315322 2 - by one flank and peak markers 5 1 94516069 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 1 93273395 2 - by one flank and peak markers 5 1 90450412 2 - by one flank and peak markers 1331757 rat Cdexp1 CD45RC expression in CD8 T cells QTL 1 9 4.3 17.5 631290 D9Wox24 44552 D9Wox21 60669 D9Got8 CD8-positive T cell quantity (VT:0008077) blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990) abnormal CD8-positive, alpha beta T cell morphology autoimmune disease 1302824 15322174 recessive 9 1 9858600 2 - by one flank and peak markers 9 1 26311568 5 - by peak with adj size 631593 631594 LEW/Rj BN/Rj 9 10869391 15509311 1 - by flanking markers 9 1024537 67509080 1 - by flanking markers 1331758 rat Bp207 Blood pressure QTL 207 3 2.848 33838 D3Mit18 33927 D3Mit3 33808 D3Mit4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp208 (maps to same region) 3 123827331 148388048 1 - by flanking markers 3 112334733 136402080 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 117303473 141971336 1 - by flanking markers 3 112287552 135181505 1 - by flanking markers 1331759 rat Hrtrt13 Heart rate QTL 13 4 3.54628 33991 D4Mit28 33832 D4Mit27 11377 D4Mit1 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate;increased heart rate variability cardiovascular system disease;hypertension 70849 11721057 Bp209 (maps to same region) 4 173580126 233483643 1 - by flanking markers 4 111754988 172369380 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 108876717 169215811 1 - by flanking markers 4 110275411 168266883 1 - by flanking markers 1331760 rat Bp206 Blood pressure QTL 206 2 3.62454 34334 D2Mgh21 34461 D2Mgh12 10387 D2Mgh26 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 75985115 235592880 1 - by flanking markers 2 56214854 210636169 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 56244671 217498710 1 - by flanking markers 2 56043031 202447032 1 - by flanking markers 1331761 rat Bp218 Blood pressure QTL 218 12 2.973 37478 D12Rat43 34455 D12Mgh8 34729 D12Mgh5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp219 (maps to same region);Hrtrt14 (maps to same region);Rf41 (maps to same region);Wbc2 (maps to same region) 12 15169677 52125243 2 - by one flank and peak markers 12 11416955 46782294 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 13127211 50320041 2 - by one flank and peak markers 12 11073825 45055165 2 - by one flank and peak markers 1331762 rat Rf40 Renal function QTL 40 10 3.873 34359 D10Mgh11 34648 D10Mgh14 34359 D10Mgh11 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) increased renal vascular resistance kidney disease;renal hypertension 70849 11721057 10 23722820 65109346 1 - by flanking markers 10 29974190 65379965 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 23861015 66539843 1 - by flanking markers 10 29299504 64155584 1 - by flanking markers 1331763 rat Wbc2 White blood cell count QTL 2 12 3.162 34246 D12Mgh3 34455 D12Mgh8 34729 D12Mgh5 leukocyte quantity (VT:0000217) total white blood cell count (CMO:0000365) increased leukocyte cell number Inflammation;heart disease 70849 11721057 Bp218 (maps to same region);Bp219 (maps to same region);Hrtrt14 (maps to same region) 12 29257552 38037368 2 - by one flank and peak markers 12 25271823 32988661 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 27285473 36161779 2 - by one flank and peak markers 12 24234777 31894213 2 - by one flank and peak markers 1331764 rat Bp205 Blood pressure QTL 205 2 3.476 36145 D2Rat73 34278 D2Mgh14 34425 D2Mgh1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 45399390 62179292 1 - by flanking markers 2 26101088 42866342 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 26267995 43133606 1 - by flanking markers 2 26999571 43154682 1 - by flanking markers 1331765 rat Hrtrt15 Heart rate QTL 15 17 4.094 34276 D17Mgh2 36329 D17Rat32 35302 D17Rat9 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate;increased heart rate variability cardiovascular system disease;hypertension 70849 11721057 Rf43 (maps to same region) 17 17801320 62813877 1 - by flanking markers 17 21286331 36519723 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 17 15743755 61036897 1 - by flanking markers 17 15330613 55836425 1 - by flanking markers 1331766 rat Bp236 Blood pressure QTL 236 18 3.022 11461 D18Mit1 10689 D18Mit5 34340 D18Mgh7 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 15314027 32348275 1 - by flanking markers 18 12406975 32458940 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 15539427 32670473 1 - by flanking markers 18 11944299 31359530 1 - by flanking markers 1331767 rat Hrtrt12 Heart rate QTL 12 2 3.373 34495 D2Mgh29 34505 D2Mgh16 33763 D2Mit15 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Cm29 (maps to same region) 2 74640967 275789260 1 - by flanking markers 2 227309864 250463890 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 235289967 257110527 1 - by flanking markers 2 218414747 240841241 1 - by flanking markers 1331768 rat Kidm10 Kidney mass QTL 10 7 4.62096 33648 D7Mit5 33729 D7Mit10 33557 D7Mit14 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) enlarged kidney kidney disease 70849 11721057 Kidm9 (maps to same region) 7 88393619 143398775 2 - by one flank and peak markers 7 85089895 140651095 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 7 88365265 133365265 4 - by one flank marker only 7 80221299 125221299 4 - by one flank marker only 1331769 rat Rf39 Renal function QTL 39 8 3.871 33858 D8Mit4 11225 D8Mgh15 33957 D8Mit16 urine output (VT:0003620) timed urine volume (CMO:0000260) polyuria kidney disease 70849 11721057 Cm30 (maps to same region) 8 44187546 105956241 1 - by flanking markers 8 44484215 103672447 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 45712344 80003418 2 - by one flank and peak markers 8 41866876 75097878 2 - by one flank and peak markers 1331770 rat Bp234 Blood pressure QTL 234 18 3.807 33884 D18Mit8 36123 D18Rat9 34182 D18Mgh3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 61176840 71374137 1 - by flanking markers 18 62228896 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 61985648 73018740 2 - by one flank and peak markers 18 59796478 71893566 2 - by one flank and peak markers 1331771 rat Rf35 Renal function QTL 35 5 4.36965 34226 D5Mgh1 36558 D5Rat19 34212 D5Mgh5 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) increased systemic arterial blood pressure hypertension 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf34 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 4566363 93491357 2 - by one flank and peak markers 5 378448 90620456 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 1 89432042 2 - by one flank and peak markers 5 729470 86724018 2 - by one flank and peak markers 1331772 rat Cdexp2 CD45RC expression in CD8 T cells QTL 2 20 5.7 22.5 34749 D20UW1 37872 D20Rat31 37594 D20Rat41 CD8-positive T cell quantity (VT:0008077) blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990) abnormal CD8-positive, alpha beta T cell morphology autoimmune disease 1302824 15322174 additive 20 6935868 12972703 1 - by flanking markers 20 3660638 10410227 1 - by flanking markers 631593 631594 LEW/Rj BN/Rj 20 4855468 10800530 1 - by flanking markers 20 3621649 10078919 1 - by flanking markers 1331773 rat Scl26 Serum cholesterol level QTL 26 5 3.065 34212 D5Mgh5 36558 D5Rat19 34419 D5Mgh25 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level familial hyperlipidemia 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region) 5 49028773 93491357 1 - by flanking markers 5 45499364 90620456 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 44404276 89432042 1 - by flanking markers 5 43726656 86724018 1 - by flanking markers 1331774 rat Bp226 Blood pressure QTL 226 18 4.41065 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331775 rat Bp235 Blood pressure QTL 235 18 3.201 34092 D18Mgh8 10689 D18Mit5 34550 D18Mgh9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 19003327 32348275 2 - by one flank and peak markers 18 15852436 32458940 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 19251717 32670473 2 - by one flank and peak markers 18 18234564 31359530 2 - by one flank and peak markers 1331776 rat Bp225 Blood pressure QTL 225 18 2.829 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331777 rat Bw24 Body weight QTL 24 3 3.503 34336 D3Mgh7 35380 D3Rat27 34146 D3Mgh6 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 70849;2298688 11721057;18612083 Bw82 (maps to same region) 3 45609749 99297680 1 - by flanking markers 3 36556706 87981257 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 40523593 92654473 1 - by flanking markers 3 39454637 89115240 1 - by flanking markers 1331778 rat Rf28 Renal function QTL 28 1 4.66 34433 D1Mgh3 10337 D1Mgh5 33931 D1Mit10 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) increased urine potassium level kidney disease 70849 11721057 Rf27 (maps to same region);Rf29 (maps to same region);Srn4 (maps to same region) 1 47428369 80946315 1 - by flanking markers 1 40204051 78134446 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 46113461 79689689 1 - by flanking markers 1 45803140 78430678 1 - by flanking markers 1331779 rat Rf38 Renal function QTL 38 6 2.876 34138 D6Mgh8 11241 D6Mit3 34184 D6Mgh11 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;kidney failure hypertension 70849 11721057 Rf37 (maps to same region) 6 44763886 85163291 1 - by flanking markers 6 32764436 75049644 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 34995656 75623393 1 - by flanking markers 6 32074428 72227641 1 - by flanking markers 1331780 rat Bp238 Blood pressure QTL 238 18 3.269 36914 D18Rat18 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region) 18 47463943 61177004 1 - by flanking markers 18 48759354 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 48248877 61985812 1 - by flanking markers 18 46718763 59796643 1 - by flanking markers 1331781 rat Scl28 Serum cholesterol level QTL 28 18 3.995 11461 D18Mit1 34550 D18Mgh9 34340 D18Mgh7 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating cholesterol level Hypercholesterolemia 70849 11721057 Bw27 (maps to same region);Rf44 (maps to same region);Scl27 (maps to same region) 18 15314027 25675871 1 - by flanking markers 18 12406975 25621024 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 15539427 25961165 1 - by flanking markers 18 11944299 24797117 1 - by flanking markers 1331782 rat Rf36 Renal function QTL 36 5 3.296 40386 D5Rat131 39378 D5Rat149 33981 D5Mit4 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate hypertension 70849 11721057 Rf32 (maps to same region);Rf33 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Scl26 (maps to same region) 5 39377361 104771061 1 - by flanking markers 5 35390492 101506667 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 85800910 100745614 2 - by one flank and peak markers 5 83840598 97059958 2 - by one flank and peak markers 1331783 rat Bp221 Blood pressure QTL 221 13 3.72886 37844 D13Rat85 33644 D13Mit4 33644 D13Mit4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;increased systemic arterial diastolic blood pressure hypertension 70849;10755344 11721057;22912817 Bp220 (maps to same region);Bp222 (maps to same region);Bp387 (maps to same region) 13 79488981 97381801 1 - by flanking markers 13 72141292 90551272 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 74568378 92916783 1 - by flanking markers 13 69060519 86800898 1 - by flanking markers 1331784 rat Bp222 Blood pressure QTL 222 13 2.944 34076 D13Mgh1 33947 D13Mit9 34351 D13Mgh4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp221 (maps to same region) 13 26674672 63533335 1 - by flanking markers 13 7538626 55033994 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 13 21482481 58537177 1 - by flanking markers 13 17694436 53050594 1 - by flanking markers 1331785 rat Rf27 Renal function QTL 27 1 4.643 35885 D1Rat8 10337 D1Mgh5 34433 D1Mgh3 urine sodium amount (VT:0006274) urine sodium level (CMO:0000129) kidney disease;renal hypertension 70849 11721057 Rf28 (maps to same region);Rf29 (maps to same region);Srn4 (maps to same region) 1 32915602 80946315 1 - by flanking markers 1 29683182 78134446 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 31489454 79689689 1 - by flanking markers 1 28879780 78430678 1 - by flanking markers 1331786 rat Kidm11 Kidney mass QTL 11 12 3.571 37478 D12Rat43 34246 D12Mgh3 34031 D12Mit7 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) enlarged kidney;increased kidney weight hypertension 70849 11721057 Bp219 (maps to same region);Rf41 (maps to same region) 12 15169677 29257669 1 - by flanking markers 12 11416955 25271941 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 13127211 27285590 1 - by flanking markers 12 11073825 24234895 1 - by flanking markers 1331787 rat Rf41 Renal function QTL 41 12 2.998 34086 D12Mgh9 34729 D12Mgh5 34086 D12Mgh9 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate hypertension 70849 11721057 Bp218 (maps to same region);Bp219 (maps to same region);Hrtrt14 (maps to same region);Kidm11 (maps to same region) 12 33647522 47758580 1 - by flanking markers 12 29130304 41447755 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 12 31723688 45946802 1 - by flanking markers 12 28064557 40218380 1 - by flanking markers 1331788 rat Rf45 Renal function QTL 45 19 2.818 33917 D19Mit4 5001959 D19Mit14 33602 D19Mit10 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) abnormal renal plasma flow rate hypertension 70849 11721057 19 28094796 63229168 2 - by one flank and peak markers 19 16770857 49024175 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 19 17028003 52538299 2 - by one flank and peak markers 19 15605023 46559041 2 - by one flank and peak markers 1331789 rat Rf37 Renal function QTL 37 6 3.224 11241 D6Mit3 40438 D6Rat163 33987 D6Mit8 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;abnormal urination pattern 70849 11721057 Rf38 (maps to same region) 6 85163175 129578985 2 - by one flank and peak markers 6 75049527 120074417 2 - by one flank and peak markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 75623277 120276465 2 - by one flank and peak markers 6 72202632 115200186 2 - by one flank and peak markers 1331790 rat Bp201 Blood pressure QTL 201 1 3.127 33878 D1Mit27 34009 D1Mit34 33945 D1Mit18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp199 (maps to same region);Bp200 (maps to same region);Hrtrt11 (maps to same region) 1 223074949 252776464 1 - by flanking markers 1 203302907 230963799 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 216213318 245529710 1 - by flanking markers 1 198211513 225126682 1 - by flanking markers 1331791 rat Cm31 Cardiac mass QTL 31 10 3.84606 34359 D10Mgh11 10466 D10Mit1 34718 D10Mgh23 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight;increased systemic arterial blood pressure Cardiomegaly;hypertension 70849 11721057 10 23722820 93929812 1 - by flanking markers 10 29974190 95369088 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 10 23861015 112626471 2 - by one flank and peak markers 10 29299504 107211142 2 - by one flank and peak markers 1331792 rat Rf29 Renal function QTL 29 1 4.589 34037 D1Mit1 10337 D1Mgh5 33931 D1Mit10 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) increased urine potassium level kidney disease 70849 11721057 Rf27 (maps to same region);Rf28 (maps to same region);Srn4 (maps to same region) 1 36630109 80946315 2 - by one flank and peak markers 1 33134446 78134446 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 36033165 79689689 2 - by one flank and peak markers 1 35239598 78430678 2 - by one flank and peak markers 1331793 rat Bp200 Blood pressure QTL 200 1 3.71601 11439 D1Mit30 34399 D1Mgh9 34011 D1Mit2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849 11721057 Bp199 (maps to same region);Bp201 (maps to same region);Hrtrt11 (maps to same region) 1 101048742 195235510 1 - by flanking markers 1 94473940 176855135 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 188289386 1 - by flanking markers 1 94494440 172949803 1 - by flanking markers 1331794 rat Bp202 Blood pressure QTL 202 2 3.66819 34114 D2Mgh15 35064 D2Rat64 34495 D2Mgh29 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 70849;10755344 11721057;22912817 Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Bp389 (maps to same region);Cm29 (maps to same region);Hrtrt12 (maps to same region) 2 166536839 258546510 1 - by flanking markers 2 146228221 232307864 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 147122993 240020001 1 - by flanking markers 2 141194931 223265385 1 - by flanking markers 1331795 rat Rf30 Renal function QTL 30 3 3.708 34336 D3Mgh7 35380 D3Rat27 34146 D3Mgh6 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) abnormal urine homeostasis;abnormal urine osmolality hypertension 70849 11721057 3 45609749 99297680 1 - by flanking markers 3 36556706 87981257 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 3 40523593 92654473 1 - by flanking markers 3 39454637 89115240 1 - by flanking markers 1331796 rat Thshl2 Thyroid stimulating hormone level QTL 2 5 2.3 39378 D5Rat149 37864 D5Rat93 40262 D5Rat157 blood thyroid-stimulating hormone amount (VT:0005119) serum thyroid stimulating hormone level (CMO:0001248) increased circulating thyroid-stimulating hormone level thyroid gland disease 1302891;10053640 15514085;21029000 2504 Dio1 Scort26 (maps to same region) 5 104751414 157347193 1 - by flanking markers 5 101506332 154014139 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 5 100723739 153577831 1 - by flanking markers 5 97059760 147465714 1 - by flanking markers 1331797 rat Bp213 Blood pressure QTL 213 6 3.291 34126 D6Mgh4 33889 D6Mit16 39256 D6Rat78 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp211 (maps to same region);Bp212 (maps to same region) 6 117391806 143011457 1 - by flanking markers 6 108503674 134379784 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 108154445 133849286 1 - by flanking markers 6 104085867 128713626 1 - by flanking markers 1331798 rat Bp224 Blood pressure QTL 224 18 3.53873 10689 D18Mit5 33884 D18Mit8 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp229 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 32348154 61177004 1 - by flanking markers 18 32458819 62229060 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 32670352 61985812 1 - by flanking markers 18 31359408 59796643 1 - by flanking markers 1331799 rat Bp211 Blood pressure QTL 211 6 3.66407 11241 D6Mit3 39256 D6Rat78 40438 D6Rat163 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp212 (maps to same region);Bp213 (maps to same region) 6 85163175 145434939 1 - by flanking markers 6 75049527 136649854 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 6 75623277 136426962 1 - by flanking markers 6 72202632 130919985 1 - by flanking markers 1331800 rat Scl25 Serum cholesterol level QTL 25 1 3.013 11439 D1Mit30 34011 D1Mit2 34381 D1Mgh7 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 70849 11721057 1 101048742 128153174 2 - by one flank and peak markers 1 94473940 134980682 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 1 99983293 127203999 2 - by one flank and peak markers 1 94494440 117601394 2 - by one flank and peak markers 1331801 rat Rf33 Renal function QTL 33 5 4.149 34212 D5Mgh5 34583 D5Rjr1 10826 D5Mgh23 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;kidney failure hypertension 70849 11721057 Rf32 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 49028773 138293117 1 - by flanking markers 5 45499364 135916908 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 44404276 134502294 1 - by flanking markers 5 43726656 129132602 1 - by flanking markers 1331802 rat Srn5 Serum renin concentration QTL 5 4 3.045 36554 D4Rat47 11377 D4Mit1 34174 D4Mgh7 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) abnormal circulating renin level hypertension 70849 11721057 Rf31 (maps to same region) 4 178652560 224309034 2 - by one flank and peak markers 4 115896404 160896404 4 - by one flank marker only 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 116726724 157291438 2 - by one flank and peak markers 4 119428175 157578333 2 - by one flank and peak markers 1331803 rat Rf32 Renal function QTL 32 5 2.798 34583 D5Rjr1 34443 D5Mgh8 34443 D5Mgh8 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) abnormal renal vascular resistance;kidney failure hypertension 70849 11721057 Rf33 (maps to same region);Rf34 (maps to same region);Rf35 (maps to same region);Rf36 (maps to same region);Scl26 (maps to same region) 5 138292944 152732057 1 - by flanking markers 5 135900621 149757440 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 5 134502121 149030144 1 - by flanking markers 5 129132428 143070159 1 - by flanking markers 1331804 rat Cm30 Cardiac mass QTL 30 8 3.77443 35663 D8Rat51 11225 D8Mgh15 33913 D8Mit13 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased body weight;increased heart weight Cardiomegaly;obesity 70849 11721057 Bp217 (maps to same region);Rf39 (maps to same region) 8 30947236 105956241 1 - by flanking markers 8 29559446 103672447 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 8 30918112 58858224 2 - by one flank and peak markers 8 28242912 53961020 2 - by one flank and peak markers 1331805 rat Cm29 Cardiac mass QTL 29 2 3.50746 34114 D2Mgh15 35064 D2Rat64 34461 D2Mgh12 heart mass (VT:0007028) heart wet weight (CMO:0000069) increased heart weight Cardiomegaly 70849 11721057 Bp202 (maps to same region);Bp203 (maps to same region);Bp204 (maps to same region);Bp205 (maps to same region);Bp206 (maps to same region);Hrtrt12 (maps to same region) 2 166536839 258546510 1 - by flanking markers 2 146228221 232307864 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 2 147122993 240020001 1 - by flanking markers 2 141194931 223265385 1 - by flanking markers 1331806 rat Bp229 Blood pressure QTL 229 18 4.36484 36914 D18Rat18 36123 D18Rat9 37738 D18Rat57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 70849 11721057 Bp224 (maps to same region);Bp225 (maps to same region);Bp226 (maps to same region);Bp227 (maps to same region);Bp228 (maps to same region);Bp230 (maps to same region);Bp231 (maps to same region);Bp232 (maps to same region);Bp233 (maps to same region);Bp234 (maps to same region);Bp235 (maps to same region);Bp236 (maps to same region);Bp237 (maps to same region);Bp238 (maps to same region) 18 47463943 71374137 1 - by flanking markers 18 48759354 72901291 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 18 48248877 59473805 2 - by one flank and peak markers 18 46718763 57867167 2 - by one flank and peak markers 1331807 rat Rf31 Renal function QTL 31 4 2.988 34238 D4Mgh2 34230 D4Mgh24 33757 D4Mit2 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) abnormal urine homeostasis;abnormal urine osmolality hypertension 70849 11721057 Srn5 (maps to same region) 4 37552221 140028145 1 - by flanking markers 4 36611842 73752590 1 - by flanking markers 10008 61499 BN/SsNHsd SS/JrHsdMcwi 4 37703272 75345433 1 - by flanking markers 4 39524264 74726312 1 - by flanking markers 1331837 rat Bw23 Body weight QTL 23 8 4.19 7.0E-5 10178 D8Wox4 11223 D8Wox6 44494 D8Got144 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1300044 15164172 8 49155635 105948812 1 - by flanking markers 8 85328126 103665018 2 - by one flank and peak markers 10017 60985 GK/KyoSwe BN 8 50529563 106506973 1 - by flanking markers 8 46531722 99083736 1 - by flanking markers 1331838 rat Niddm61 Non-insulin dependent diabetes mellitus QTL 61 8 3.53 4.0E-4 10819 D8Got43 11223 D8Wox6 44445 D8Got99 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level;increased insulin secretion type 2 diabetes mellitus 1300044 15164172 8 39232847 105948812 1 - by flanking markers 8 38003289 103665018 1 - by flanking markers 10017 60985 GK/KyoSwe BN 8 39230130 106506973 1 - by flanking markers 8 36469535 99083736 1 - by flanking markers 1331839 rat Eae18b Experimental allergic encephalomyelitis QTL 18b 10 5.8 0.03 42921 D10Rat243 36916 D10Rat58 37170 D10Rat123 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) paralysis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 1302437;4145472 15240732;19865101 3644;3645;1586495 Ccl11;Ccl2;Ccl1 recessive 10 63463237 70966782 1 - by flanking markers 10 67774947 71067824 1 - by flanking markers Intercross 1331833 DA.ACI-(D10Rat15-D10Rat29) 10 64550912 70202084 1 - by flanking markers 10 61248303 67785171 1 - by flanking markers 1354580 rat Scort1 Serum corticosterone level QTL 1 1 3.4 36105 D1Rat51 34194 D1Mgh14 37184 D1Rat188 blood corticosterone amount (VT:0005345) blood corticosterone level (CMO:0001172) abnormal circulating corticosterone level hypertension 1302893 15452030 1 173583273 285604895 1 - by flanking markers 1 159782445 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 167394665 278228889 1 - by flanking markers 1 156677124 256448636 1 - by flanking markers 1354581 rat Bp247 Blood pressure QTL 247 17 4.5 38884 D17Rat94 35473 D17Rat58 38772 D17Rat102 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) abnormal systemic arterial blood pressure;increased pulse pressure hypertension 1302893 15452030 17 1 75089871 2 - by one flank and peak markers 17 1 81039660 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 1 73413148 2 - by one flank and peak markers 17 1 69599340 2 - by one flank and peak markers 1354582 rat Stl11 Serum triglyceride level QTL 11 7 3.42 35773 D7Rat8 34393 D7Mgh20 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 7 129105387 143501887 4 - by one flank marker only 7 126748283 143002779 4 - by one flank marker only 61014 70509 OLETF F344/NRrrc 7 129412003 145729302 4 - by one flank marker only 7 119513385 135012528 4 - by one flank marker only 1354583 rat Despr3 Despair related QTL3 5 4.98 2.0E-4 3.6 37112 D5Rat40 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 61105 61109 WKY/NHsd F344/NHsd 1354584 rat Despr6 Despair related QTL 6 16 3.1 0.0067 2.3 42022 D16Arb5 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 16 1 41109533 5 - by peak with adj size 16 1 40096603 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 16 1 41240937 5 - by peak with adj size 16 1 39533930 5 - by peak with adj size 1354585 rat Eae18a Experimental allergic encephalomyelitis QTL 18a 10 7.5 4.0E-4 11479 D10Mit8 1303359 D10Got166 1303357 D10Got165 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) paralysis Experimental Autoimmune Encephalomyelitis;multiple sclerosis 1302437;2293859;2306769 15240732;16624898;19299744 additive Eae23 (sub_region);Ean3 (maps to same region) 10 55422036 60141913 1 - by flanking markers 10 55851702 60865280 1 - by flanking markers Intercross 1331824 DA.ACI-(D10Rat219-D10Rat29) 10 55678976 60404791 1 - by flanking markers 10 53797385 58445852 1 - by flanking markers 1354586 rat Despr1 Despair related QTL 1 2 4.88 0.0035 1.9 39914 D2Rat188 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894;1358767 15457344;15685431 Stresp13 (maps to same region) 1 122414658 167414658 5 - by peak with adj size 2 1 23400664 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1354587 rat Kidm21 Kidney mass QTL 21 10 3.3 41030 D10Rat183 36319 D10Rat26 40978 D10Rat168 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) abnormal kidney weight hypertension 1302893 15452030 10 15188449 62219555 2 - by one flank and peak markers 10 15274216 62791536 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 10 15375474 62469074 2 - by one flank and peak markers 10 15028513 60430477 2 - by one flank and peak markers 1354588 rat Bvd4 Brain ventricular dilatation QTL 4 17 5.31 0.001 38464 D17Rat79 39318 D17Rat65 10348 D17Mit4 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 17 54261257 88435496 1 - by flanking markers 17 62026925 93930006 1 - by flanking markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 17 56224296 86731080 1 - by flanking markers 17 53498828 82479847 1 - by flanking markers 1354589 rat Bw31 Body weight QTL 31 3 3.3 38346 D3Rat98 35086 D3Rat31 35947 D3Rat45 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893;2298688 15452030;18612083 Bw82 (maps to same region) 3 38636977 87839442 1 - by flanking markers 3 30253942 76620970 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 3 33477354 81136227 1 - by flanking markers 3 33703347 78196190 1 - by flanking markers 1354590 rat Despr11 Despair related QTL 11 3 3.1E-5 4.8 41162 D3Rat181 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894;2312611 15457344;19697080 Gluco46 (maps to same region) 3 36534996 81534996 5 - by peak with adj size 3 25754538 70754538 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 3 29908255 74908255 5 - by peak with adj size 3 28468571 73468571 5 - by peak with adj size 1354591 rat Cm36 Cardiac mass QTL 36 1 4.1 35220 D1Rat29 37184 D1Rat188 38564 D1Rat140 heart left ventricle mass (VT:0007031) calculated heart weight (CMO:0000073) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 1 110018554 226102807 1 - by flanking markers 1 103149923 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 219232156 1 - by flanking markers 1 102813953 201278233 1 - by flanking markers 1354592 rat Rf50 Renal function QTL 50 2 3.5 36902 D2Rat270 35643 D2Rat21 33765 D2Mit35 urine output (VT:0003620) timed urine volume (CMO:0000260) polyuria hypertension 1302893 15452030 2 73465326 95410202 1 - by flanking markers 2 53661468 75806439 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 54436698 75687607 1 - by flanking markers 2 53822747 74786777 1 - by flanking markers 1354593 rat Stl12 Serum triglyceride level QTL 12 11 3.36 34725 D11Mgh3 34118 D11Mgh2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 11 72739687 93518069 4 - by one flank marker only 11 68234781 87759784 4 - by one flank marker only 61014 70509 OLETF F344/NRrrc 11 69649708 90463843 4 - by one flank marker only 11 66422148 86241447 4 - by one flank marker only 1354594 rat Despr10 Despair related QTL 10 2 2.49E-6 7.8 41152 D2Rat220 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 2 139475534 184475534 5 - by peak with adj size 2 119504072 164504072 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 2 119789823 164789823 5 - by peak with adj size 2 114654253 159654253 5 - by peak with adj size 1354595 rat Despr4 Despair related QTL 4 8 2.16 0.0036 1.8 37742 D8Rat163 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 8 10411269 55411269 5 - by peak with adj size 8 9008612 54008612 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 8 10388439 55388439 5 - by peak with adj size 8 7688955 52688955 5 - by peak with adj size 1354596 rat Bw32 Body weight QTL 32 17 4.5 35176 D17Rat2 35585 D17Rat151 38884 D17Rat94 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893;2312611 15452030;19697080 Bw91 (maps to same region) 17 5553716 65440857 1 - by flanking markers 17 9988620 71570057 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 63676140 1 - by flanking markers 17 4299130 60781592 1 - by flanking markers 1354597 rat Kidm13 Kidney mass QTL 13 3 2.9 10678 D3Mgh21 40934 D3Rat165 42139 D3Arb8 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) abnormal kidney weight hypertension 1302893 15452030 3 48366676 115471051 1 - by flanking markers 3 39052756 103304908 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 3 43295930 108914061 1 - by flanking markers 3 41874578 104104347 1 - by flanking markers 1354598 rat Srn6 Serum renin concentration QTL 6 5 3.8 37440 D5Rat84 39478 D5Rat204 37944 D5Rat83 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) abnormal circulating renin level;decreased circulating renin level Metabolic Syndrome;cardiovascular system disease;kidney disease 1302893 15452030 5 75720253 160966475 1 - by flanking markers 5 71971592 157597184 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 5 71552569 157225114 1 - by flanking markers 5 69540295 151018848 1 - by flanking markers 1354599 rat Bw29 Body weight QTL 29 1 3.46 0.001 7.0 40798 D1Rat256 body mass (VT:0001259) body weight (CMO:0000012) weight loss Adrenal Insufficiency 1302889 15252022 1 35632458 80632458 5 - by peak with adj size 1 31371950 76371950 5 - by peak with adj size 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 1 34449112 79449112 5 - by peak with adj size 1 33449848 78449848 5 - by peak with adj size 1354600 rat Salc2 Saline consumption QTL 2 19 9.91 0.001 29.8 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 drinking behavior trait (VT:0001422) saline drink intake rate (CMO:0001627) abnormal drinking behavior Adrenal Insufficiency 1302889 15252022 3094 Nr3c2 19 42098191 52509704 1 - by flanking markers 19 25548711 39854409 2 - by one flank and peak markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 19 31194301 41686140 1 - by flanking markers 19 27530207 37947399 1 - by flanking markers 1354601 rat Slep1 Serum leptin concentration QTL 1 2 5.39 0.065 60793 D2Wox3 34234 D2Mgh9 33850 D2Mit30 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 737686 14724732 dominant 2 62195476 218191419 1 - by flanking markers 2 42882523 191378271 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 2 43149788 198704485 1 - by flanking markers 2 43171017 184114403 1 - by flanking markers 1354602 rat Bw35 Body weight QTL 35 1 12.2 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354603 rat Bp243 Blood pressure QTL 243 2 3.9 38976 D2Rat124 33765 D2Mit35 36902 D2Rat270 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) abnormal systemic arterial blood pressure;increased systemic arterial diastolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 2 45317613 155139446 1 - by flanking markers 2 1 131530924 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 2 26186097 135654963 1 - by flanking markers 2 26917817 127469484 1 - by flanking markers 1354604 rat Bw36 Body weight QTL 36 3 2.9 38346 D3Rat98 40934 D3Rat165 42139 D3Arb8 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893;2298688 15452030;18612083 Bw82 (maps to same region) 3 38636977 115471051 1 - by flanking markers 3 30253942 103304908 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 3 33477354 108914061 1 - by flanking markers 3 33703347 104104347 1 - by flanking markers 1354605 rat Rf48 Renal function QTL 48 2 2.9 35643 D2Rat21 38466 D2Rat118 41300 D2Rat221 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) abnormal circulating creatinine level hypertension 1302893 15452030 2 95410090 239931716 1 - by flanking markers 2 75806326 214989298 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 75687495 221880419 1 - by flanking markers 2 74786664 206665859 1 - by flanking markers 1354606 rat Bp246 Blood pressure QTL 246 1 3.6 35220 D1Rat29 33945 D1Mit18 40876 D1Rat278 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) abnormal systemic arterial blood pressure;increased pulse pressure hypertension 1302893 15452030 1 110018554 246119106 1 - by flanking markers 1 103149923 224426393 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 238830534 1 - by flanking markers 1 102813953 218753816 1 - by flanking markers 1354607 rat Gmadr1 Adrenal mass QTL 1 19 5.83 24.4 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) small adrenal glands Adrenal Insufficiency;adrenal gland disease 1302889 15252022 3094 Nr3c2 19 42098191 52509704 1 - by flanking markers 19 25548711 39854409 2 - by one flank and peak markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 19 31194301 41686140 1 - by flanking markers 19 27530207 37947399 1 - by flanking markers 1354608 rat Cm33 Cardiac mass QTL 33 10 2.8 36087 D10Rat156 34813 D10Rat16 36319 D10Rat26 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 10 56440444 96133217 1 - by flanking markers 10 56930545 97589703 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 10 56698730 101698730 4 - by one flank marker only 10 54809292 99809292 4 - by one flank marker only 1354609 rat Niddm62 Non-insulin dependent diabetes mellitus QTL 62 2 4.72 6.0E-6 34204 D2Mgh7 34461 D2Mgh12 35423 D2Rat41 insulin secretion trait (VT:0003564) plasma insulin level (CMO:0000342) impaired glucose tolerance;increased circulating insulin level;increased insulin secretion hyperinsulinism;type 2 diabetes mellitus 1302801 15266047 62007;70972 Ensa;Hao2 2 177516922 235592880 1 - by flanking markers 2 156142685 210636169 1 - by flanking markers 10017 60985 GK/KyoSwe BN 2 158159186 217498710 1 - by flanking markers 2 150540301 202447032 1 - by flanking markers 1354610 rat Bw34 Body weight QTL 34 1 4.1 38564 D1Rat140 34194 D1Mgh14 37184 D1Rat188 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893 15452030 1 167997630 285604895 1 - by flanking markers 1 154074905 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 278228889 1 - by flanking markers 1 151162512 256448636 1 - by flanking markers 1354611 rat Despr2 Despair related QTL 2 3 3.03 0.0028 1.9 38318 D3Rat71 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 3 108960777 153960777 5 - by peak with adj size 3 97595472 142595472 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 3 102466149 147466149 5 - by peak with adj size 3 97084464 142084464 5 - by peak with adj size 1354612 rat Foco1 Food consumption QTL 1 4 8.87 37592 D4Rat141 35625 D4Rat14 34943 D4Rat30 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) abnormal food intake Adrenal Insufficiency 1302889 15252022 4 44024417 210231569 1 - by flanking markers 4 41729771 151158666 1 - by flanking markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 4 43414792 146942075 1 - by flanking markers 4 44463908 148090542 1 - by flanking markers 1354613 rat Kidm14 Kidney mass QTL 14 17 6.2 35176 D17Rat2 36011 D17Rat17 38884 D17Rat94 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight hypertension 1302893 15452030 17 5553716 39651411 1 - by flanking markers 17 9988620 42344987 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 37790462 1 - by flanking markers 17 4299130 35837242 1 - by flanking markers 1354614 rat Hpcl1 Hepatic cholesterol level QTL 1 10 3.3 33909 D10Mit4 3138 Myh3 33909 D10Mit4 liver cholesterol amount (VT:0010498) liver cholesterol level (CMO:0001597) abnormal cellular cholesterol metabolism;increased cholesterol level 629576 9600105 69423 Srebf1 10 36354729 53396227 1 - by flanking markers 10 36649906 53800677 1 - by flanking markers 61098 68049 BXH/Ipcv HXB-1-43/Ipcv 10 36584373 53645194 1 - by flanking markers 10 35392267 51793994 1 - by flanking markers 1354615 rat Cm32 Cardiac mass QTL 32 1 5.2 35220 D1Rat29 37184 D1Rat188 36105 D1Rat51 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 1 110018554 226102807 1 - by flanking markers 1 103149923 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 219232156 1 - by flanking markers 1 102813953 201278233 1 - by flanking markers 1354616 rat Despr12 Despair related QTL 12 6 0.0012 2.1 35963 D6Rat46 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894;1358767 15457344;15685431 Stresp10 (maps to same region) 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 1354617 rat Bp240 Blood pressure QTL 240 2 4.0 38976 D2Rat124 41788 D2Rat275 36902 D2Rat270 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial blood pressure Metabolic Syndrome;hypertension 1302893 15452030 2 45317613 103494306 1 - by flanking markers 2 24496771 82826337 2 - by one flank and peak markers Intercross 10021 10022 LH/Mav LN/Mav 2 26186097 83819822 1 - by flanking markers 2 26917817 81754745 1 - by flanking markers 1354618 rat Kidm15 Kidney mass QTL 15 1 5.0 36105 D1Rat51 37184 D1Rat188 40876 D1Rat278 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight hypertension 1302893 15452030 1 173583273 226102807 1 - by flanking markers 1 159782445 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 167394665 219232156 1 - by flanking markers 1 156677124 201278233 1 - by flanking markers 1354619 rat Bp242 Blood pressure QTL 242 17 6.3 38884 D17Rat94 35473 D17Rat58 37494 D17Rat98 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial systolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 17 30089871 75089871 4 - by one flank marker only 17 47055924 81039660 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 28413148 73413148 4 - by one flank marker only 17 24599340 69599340 4 - by one flank marker only 1354620 rat Kidm19 Kidney mass QTL 19 1 4.0 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354621 rat Rf47 Renal function QTL 47 13 3.7 39804 D13Rat111 40468 D13Rat163 35997 D13Rat26 kidney renin amount (VT:0010559) kidney renin level (CMO:0002166) abnormal circulating renin level hypertension 1302893 15452030 13 40421740 112605698 1 - by flanking markers 13 32030139 105788017 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 13 35301263 107975663 1 - by flanking markers 13 30395351 101056920 1 - by flanking markers 1354622 rat Kidm16 Kidney mass QTL 16 2 3.0 41788 D2Rat275 36962 D2Rat63 38960 D2Rat93 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) abnormal kidney weight hypertension 1302893 15452030 2 103494092 257699856 1 - by flanking markers 2 82826122 231465091 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 83819608 239166203 1 - by flanking markers 2 81754530 222436696 1 - by flanking markers 1354623 rat Rf46 Renal function QTL 46 1 3.8 35220 D1Rat29 38564 D1Rat140 34922 D1Rat43 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) abnormal circulating creatinine level hypertension 1302893 15452030 1 110018554 167997883 1 - by flanking markers 1 103149923 154075310 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 108986301 161784422 1 - by flanking markers 1 102813953 151162766 1 - by flanking markers 1354624 rat Cm35 Cardiac mass QTL35 1 5.7 37560 D1Rat155 34194 D1Mgh14 33945 D1Mit18 heart left ventricle mass (VT:0007031) calculated heart weight (CMO:0000073) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 1 199702920 285604895 1 - by flanking markers 1 181524849 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 192639698 278228889 1 - by flanking markers 1 177227632 256448636 1 - by flanking markers 1354625 rat Despr7 Despair related QTL 7 16 3.16 0.016 2.0 40052 D16Rat75 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894 15457344 16 1612700 46612700 5 - by peak with adj size 16 1632183 46632183 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 16 1728297 46728297 5 - by peak with adj size 16 1 44977551 5 - by peak with adj size 1354626 rat Bvd1 Brain ventricular dilatation QTL 1 9 3.73 0.001 38048 D9Rat90 36325 D9Rat1 35789 D9Rat2 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 9 81176785 119437586 1 - by flanking markers 9 73454285 110864247 1 - by flanking markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 9 81411073 119983851 1 - by flanking markers 9 75712843 111552878 1 - by flanking markers 1354627 rat Despr14 Despair related QTL 14 8 0.0056 2.0 37742 D8Rat163 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 8 10411269 55411269 5 - by peak with adj size 8 9008612 54008612 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 8 10388439 55388439 5 - by peak with adj size 8 7688955 52688955 5 - by peak with adj size 1354628 rat Stl13 Serum triglyceride level QTL 13 17 3.8 38772 D17Rat102 35585 D17Rat151 36011 D17Rat17 blood triglyceride amount (VT:0002644) blood triglyceride level (CMO:0000118) abnormal triglyceride level;increased circulating VLDL cholesterol level;increased circulating triglyceride level Hypercholesterolemia;Hypertriglyceridemia;Metabolic Syndrome 1302893 15452030 17 25980198 65440857 1 - by flanking markers 17 27118351 71570057 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 24030618 63676140 1 - by flanking markers 17 21293039 60781592 1 - by flanking markers 1354629 rat Scl31 Serum cholesterol level QTL 31 17 4.1 38884 D17Rat94 35585 D17Rat151 36329 D17Rat32 blood cholesterol amount (VT:0000180) blood total cholesterol level (CMO:0000051) abnormal circulating cholesterol level;increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1302893 15452030 17 60186503 65440857 2 - by one flank and peak markers 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 58397260 63676140 2 - by one flank and peak markers 17 50890908 60781592 2 - by one flank and peak markers 1354630 rat Cm34 Cardiac mass QTL 34 17 8.7 35176 D17Rat2 35473 D17Rat58 38884 D17Rat94 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) abnormal heart size;heart left ventricle hypertrophy Left Ventricular Hypertrophy;Metabolic Syndrome 1302893 15452030 17 5553716 75089871 1 - by flanking markers 17 9988620 81039660 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 73413148 1 - by flanking markers 17 4299130 69599340 1 - by flanking markers 1354631 rat Swd2 Spike wave discharge measurement QTL 2 5 3.64 2.0E-4 39168 D5Rat99 39700 D5Rat185 34206 D5Mgh15 brain electrophysiology trait (VT:0010557) brain total spike-and-wave discharge duration (CMO:0001740) increased spike-wave discharge type II childhood absence epilepsy 1302436 15270755 5 161060798 174683006 1 - by flanking markers 5 157691737 170688737 1 - by flanking markers Intercross 10000 737924 ACI/N WAG/Rij 5 157319671 171194163 1 - by flanking markers 5 151113452 164465185 1 - by flanking markers 1354632 rat Scl29 Serum cholesterol level QTL 29 6 3.74 35390 D6Rat36 36729 D6Rat23 11141 D6Arb12 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 737686 14724732 6 50735827 84567936 1 - by flanking markers 6 35883625 74436995 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 6 37608980 75023446 1 - by flanking markers 6 35098709 71636405 1 - by flanking markers 1354633 rat Bw28 Body weight QTL 28 19 6.04 60781 D19Wox3 11390 D19Wox4 3094 Nr3c2 body mass (VT:0001259) body weight (CMO:0000012) weight loss Adrenal Insufficiency 1302889 15252022 3094 Nr3c2 19 42098191 52509704 1 - by flanking markers 19 25548711 39854409 2 - by one flank and peak markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 19 31194301 41686140 1 - by flanking markers 19 27530207 37947399 1 - by flanking markers 1354634 rat Kidm12 Kidney mass QTL 12 1 3.9 38564 D1Rat140 37184 D1Rat188 40876 D1Rat278 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) abnormal kidney weight hypertension 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354635 rat Bp245 Blood pressure QTL 245 17 6.0 38884 D17Rat94 35473 D17Rat58 36329 D17Rat32 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure;increased systemic arterial blood pressure Metabolic Syndrome;hypertension 1302893 15452030 17 50537489 75089871 2 - by one flank and peak markers 17 36039660 81039660 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 48660252 73413148 2 - by one flank and peak markers 17 42073160 69599340 2 - by one flank and peak markers 1354636 rat Lmblg1 Limb length QTL 1 1 6.4 38564 D1Rat140 37184 D1Rat188 36105 D1Rat51 tibia length (VT:0004357) tibia length (CMO:0000450) abnormal tibia morphology 1302893 15452030 1 167997630 226102807 1 - by flanking markers 1 154074905 206567907 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 219232156 1 - by flanking markers 1 151162512 201278233 1 - by flanking markers 1354637 rat Scl30 Serum cholesterol level QTL 30 7 3.7 35068 D7Rat32 39012 D7Rat98 34051 D7Mit28 blood cholesterol amount (VT:0000180) blood total cholesterol level (CMO:0000051) abnormal circulating cholesterol level;increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1302893 15452030 7 25506703 57077089 1 - by flanking markers 7 21790655 53398255 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 7 25365633 57064364 1 - by flanking markers 7 19654317 49753746 1 - by flanking markers 1354638 rat Insul1 Insulin level QTL 1 17 4.8 35176 D17Rat2 35473 D17Rat58 36329 D17Rat32 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) abnormal circulating insulin level Metabolic Syndrome 1302893 15452030 17 5553716 75089871 1 - by flanking markers 17 9988620 81039660 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 73413148 1 - by flanking markers 17 4299130 69599340 1 - by flanking markers 1354639 rat Spl5 Serum phospholipid level QTL 5 7 3.9 35068 D7Rat32 10880 D7Mgh22 34051 D7Mit28 blood LDL phospholipid amount (VT:0010505) blood low density lipoprotein phospholipid level (CMO:0001568) abnormal circulating LDL cholesterol level hypertension 1302893 15452030 7 25506703 60319594 1 - by flanking markers 7 21790655 56589443 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 7 25365633 60317612 1 - by flanking markers 7 19654317 52888450 1 - by flanking markers 1354640 rat Scl32 Serum cholesterol level QTL 32 17 5.4 38884 D17Rat94 35585 D17Rat151 36331 D17Mit12 blood HDL cholesterol amount (VT:0000184) blood high density lipoprotein cholesterol level (CMO:0000052) abnormal circulating HDL cholesterol level;increased circulating HDL cholesterol level Hypercholesterolemia;Metabolic Syndrome 1302893 15452030 17 20440857 65440857 4 - by one flank marker only 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 18676140 63676140 4 - by one flank marker only 17 15781592 60781592 4 - by one flank marker only 1354641 rat Bvd2 Brain ventricular dilatation QTL 2 10 6.36 0.001 39928 D10Rat189 35254 D10Rat2 41382 D10Rat136 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 10 96247437 110568670 1 - by flanking markers 10 79981838 110718848 5 - by peak with adj size backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 10 96520816 110992275 1 - by flanking markers 10 93223816 107057807 1 - by flanking markers 1354642 rat Despr15 Despair related QTL 15 20 0.0027 3.1 35188 D20Rat1 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 20 1 26689404 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 20 1 24652101 5 - by peak with adj size 20 1 24159021 5 - by peak with adj size 1354643 rat Foco2 Food consumption QTL 2 1 7.17 1.0E-4 14.4 40798 D1Rat256 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) abnormal food intake Adrenal Insufficiency 1302889 15252022 1 35632458 80632458 5 - by peak with adj size 1 31371950 76371950 5 - by peak with adj size 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 1 34449112 79449112 5 - by peak with adj size 1 33449848 78449848 5 - by peak with adj size 1354644 rat Spl4 Serum phospholipid level QTL 4 7 4.9 35068 D7Rat32 39012 D7Rat98 34051 D7Mit28 blood phospholipid amount (VT:0006084) blood phospholipid level (CMO:0001169) abnormal circulating phospholipid level hypertension 1302893 15452030 7 25506703 57077089 1 - by flanking markers 7 21790655 53398255 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 7 25365633 57064364 1 - by flanking markers 7 19654317 49753746 1 - by flanking markers 1354645 rat Swd1 Spike wave discharge measurement QTL 1 9 3.91 1.2E-4 40510 D9Rat109 41672 D9Rat163 38536 D9Rat103 brain electrophysiology trait (VT:0010557) mean duration of a single type I spike-and-wave discharge train (CMO:0002064) increased spike-wave discharge type I childhood absence epilepsy 1302436 15270755 9 106780549 109609577 1 - by flanking markers 9 100495066 101209445 1 - by flanking markers Intercross 10000 737924 ACI/N WAG/Rij 9 107198926 110038814 1 - by flanking markers 9 101597509 102302863 1 - by flanking markers 1354646 rat Kidm18 Kidney mass QTL 18 1 5.7 38564 D1Rat140 34194 D1Mgh14 37184 D1Rat188 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 1 167997630 285604895 1 - by flanking markers 1 154074905 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 278228889 1 - by flanking markers 1 151162512 256448636 1 - by flanking markers 1354647 rat Despr8 Despair related QTL 8 1 3.41E-5 7.3 39666 D1Rat246 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 1 1 26064717 5 - by peak with adj size 1 1 24936947 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1 1 24368159 5 - by peak with adj size 1 1 24744506 5 - by peak with adj size 1354648 rat Bp239 Blood pressure QTL 239 2 0.001 2044 Adh1c 33739 D2Mit5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 629612;10755344 9260980;22912817 Bp389 (maps to same region) 2 86560306 262090818 1 - by flanking markers 2 66680209 235799396 1 - by flanking markers 1357190 SS.MNS-(Adh1-D2Mit5)/Mco 2 66828236 243550655 1 - by flanking markers 2 66118463 226797303 1 - by flanking markers 1354649 rat Kidm17 Kidney mass QTL 17 2 2.9 41788 D2Rat275 36081 D2Rat294 38960 D2Rat93 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 2 103494092 262435073 1 - by flanking markers 2 82826122 236153712 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 2 83819608 243901375 1 - by flanking markers 2 81754530 227146641 1 - by flanking markers 1354650 rat Despr5 Despair related QTL 5 9 4.01 0.0017 2.9 40738 D9Rat130 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) behavioral despair depressive disorder 1302894;2312611 15457344;19697080 Gluco54 (maps to same region) 9 3833388 48833388 5 - by peak with adj size 9 1 42602240 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 9 4986095 49986095 5 - by peak with adj size 9 1254084 46254084 5 - by peak with adj size 1354651 rat Lmblg2 Limb length QTL 2 17 6.0 35176 D17Rat2 35473 D17Rat58 38884 D17Rat94 tibia length (VT:0004357) tibia length (CMO:0000450) abnormal tibia morphology 1302893 15452030 17 5553716 75089871 1 - by flanking markers 17 9988620 81039660 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 17 3336972 73413148 1 - by flanking markers 17 4299130 69599340 1 - by flanking markers 1354652 rat Kidm20 Kidney mass QTL 20 1 4.3 37560 D1Rat155 34194 D1Mgh14 33945 D1Mit18 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) abnormal kidney weight hypertension 1302893 15452030 1 199702920 285604895 1 - by flanking markers 1 181524849 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 192639698 278228889 1 - by flanking markers 1 177227632 256448636 1 - by flanking markers 1354653 rat Despr9 Despair related QTL 9 1 1.9E-4 2.7 39152 D1Rat147 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 1 192322095 237322095 5 - by peak with adj size 1 172723568 217723568 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1 185390068 230390068 5 - by peak with adj size 1 167909849 212909849 5 - by peak with adj size 1354654 rat Spl7 Serum phospholipid level QTL 7 17 5.5 38884 D17Rat94 35585 D17Rat151 36329 D17Rat32 blood phospholipid amount (VT:0006084) blood phospholipid level (CMO:0001169) abnormal circulating phospholipid level hypertension 1302893 15452030 17 60186503 65440857 2 - by one flank and peak markers 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 58397260 63676140 2 - by one flank and peak markers 17 50890908 60781592 2 - by one flank and peak markers 1354655 rat Bp241 Blood pressure QTL 241 13 3.9 41340 D13Rat116 40468 D13Rat163 41588 D13Rat128 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial systolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 13 46437046 112605698 1 - by flanking markers 13 37458331 105788017 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 13 62975663 107975663 4 - by one flank marker only 13 56056920 101056920 4 - by one flank marker only 1354656 rat Bvd3 Brain ventricular dilatation QTL 3 11 3.64 0.001 41256 D11Rat61 37512 D11Rat50 37942 D11Rat46 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890;68196 15473982;11178739 Bvd6 (sub_region) 11 75797786 90087579 1 - by flanking markers 11 77341660 84841212 2 - by one flank and peak markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 11 72720029 86994795 1 - by flanking markers 11 69446070 82846715 1 - by flanking markers 1354657 rat Despr13 Despair related QTL 13 15 0.0022 2.6 36516 D15Rat1 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) behavioral despair depressive disorder 1302894 15457344 15 1 34660252 5 - by peak with adj size 15 1 31488303 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 15 1 30597196 5 - by peak with adj size 15 1 29912054 5 - by peak with adj size 1354658 rat Spl8 Serum phospholipid level QTL 8 17 3.8 38884 D17Rat94 35585 D17Rat151 38772 D17Rat102 blood VLDL phospholipid amount (VT:0010507) blood very low density lipoprotein phospholipid level (CMO:0001571) abnormal circulating VLDL cholesterol level hypertension 1302893 15452030 17 1 65440857 2 - by one flank and peak markers 17 1 71570057 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 1 63676140 2 - by one flank and peak markers 17 1 60781592 2 - by one flank and peak markers 1354659 rat Scl68 Serum cholesterol level QTL 68 17 3.9 38884 D17Rat94 35585 D17Rat151 36331 D17Mit12 blood VLDL cholesterol amount (VT:0005144) blood very low density lipoprotein cholesterol level (CMO:0000648) abnormal circulating VLDL cholesterol level hypertension 1302893 15452030 17 20440857 65440857 4 - by one flank marker only 17 26570057 71570057 4 - by one flank marker only intercross 10021 10022 LH/Mav LN/Mav 17 18676140 63676140 4 - by one flank marker only 17 15781592 60781592 4 - by one flank marker only 1354660 rat Salc1 Saline consumption QTL 1 4 11.26 20.8 37592 D4Rat141 35625 D4Rat14 34943 D4Rat30 drinking behavior trait (VT:0001422) saline drink intake rate (CMO:0001627) abnormal drinking behavior Adrenal Insufficiency 1302889 15252022 4 44024417 210231569 1 - by flanking markers 4 41729771 151158666 1 - by flanking markers 1354669 1354670 BN/OrlIcoCrlf F344/IcoCrlf 4 43414792 146942075 1 - by flanking markers 4 44463908 148090542 1 - by flanking markers 1354661 rat Bw33 Body weight QTL 33 1 5.2 38564 D1Rat140 34194 D1Mgh14 36021 D1Rat115 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight obesity 1302893 15452030 1 167997630 285604895 1 - by flanking markers 1 154074905 263699089 1 - by flanking markers intercross 10021 10022 LH/Mav LN/Mav 1 161784169 278228889 1 - by flanking markers 1 151162512 256448636 1 - by flanking markers 1354662 rat Rf49 Renal function QTL 49 17 2.9 38884 D17Rat94 35473 D17Rat58 38772 D17Rat102 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) abnormal circulating creatinine level hypertension 1302893 15452030 17 1 75089871 2 - by one flank and peak markers 17 1 81039660 2 - by one flank and peak markers intercross 10021 10022 LH/Mav LN/Mav 17 1 73413148 2 - by one flank and peak markers 17 1 69599340 2 - by one flank and peak markers 1354663 rat Bvd5 Brain ventricular dilatation QTL 5 17 3.51 0.001 33882 D17Mit2 41762 D17Rat154 41762 D17Rat154 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) abnormal brain ventricle morphology;hydrocephaly hydrocephalus 1302890 15473982 17 35195242 87045172 1 - by flanking markers 17 38353858 92741218 1 - by flanking markers backcrosstoH-Tx/Hcj 61109 68189 F344/NHsd HTX/Hcj 17 33303627 85321557 1 - by flanking markers 17 31990784 81292925 1 - by flanking markers 1354664 rat Slep2 Serum leptin concentration QTL 2 6 4.49 0.08 37142 D6Rat80 36729 D6Rat23 35390 D6Rat36 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 737686 14724732 dominant 6 1111498 84567936 1 - by flanking markers 6 1301952 74436995 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 6 1120393 75023446 1 - by flanking markers 6 16536140 71636405 1 - by flanking markers 1354665 rat Stl10 Serum triglyceride level QTL 10 4 3.57 34200 D4Mgh1 35625 D4Rat14 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia 737686 14724732 4 18184531 44024417 1 - by flanking markers 4 17617956 41729771 1 - by flanking markers 61014 70509 OLETF F344/NRrrc 4 18222187 43414792 1 - by flanking markers 4 21333343 44463908 1 - by flanking markers 1354666 rat Bp244 Blood pressure QTL 244 13 4.9 37316 D13Rat53 40468 D13Rat163 40948 D13Rat120 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) abnormal systemic arterial blood pressure;increased systemic arterial diastolic blood pressure Metabolic Syndrome;hypertension 1302893 15452030 13 1 112605698 2 - by one flank and peak markers 13 1 105788017 2 - by one flank and peak markers Intercross 10021 10022 LH/Mav LN/Mav 13 1 107975663 2 - by one flank and peak markers 13 1 101056920 2 - by one flank and peak markers 1357335 rat Bw39 Body weight QTL 39 1 3.3 32.0 2870 Igf2 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) obesity 69707;1303386 9530522;14640890 1 222722921 270717037 1 - by flanking markers 1 202906624 247322277 1 - by flanking markers backcross 61107 61110 BB/OK SHR/Mol 1 215828102 260828102 4 - by one flank marker only 1 197814409 242814409 4 - by one flank marker only 1357336 rat Gluco6 Glucose level QTL 6 7 3.4 33670 D7Mit2 33969 D7Mit4 33749 D7Mit3 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543) abnormal glucose tolerance;impaired glucose tolerance Insulin Resistance;glucose intolerance 619533 12016513 additive 7 104437717 125794079 1 - by flanking markers 7 100273797 123191595 1 - by flanking markers 629499 BXS/Ipcv 7 103867802 126080176 1 - by flanking markers 7 94811326 116294265 1 - by flanking markers 1357337 rat Gluco3 Glucose level QTL 3 12 4.0E-4 34025 D12Mit8 34439 D12Mgh1 adipocyte glucose uptake trait (VT:0004185) absolute change in adipocyte glucose uptake (CMO:0000873) abnormal adipocyte glucose uptake Metabolic Syndrome;type 2 diabetes mellitus 61078 9171835 dominant 12 1 15941791 4 - by one flank marker only 12 1 12240883 4 - by one flank marker only 61096 61097 SHR/NCruk WKY/NCruk 1357338 rat Stl17 Serum triglyceride level QTL 17 7 3.23 34096 D7Mgh4 34499 D7Mgh7 34555 D7Mgh6 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level familial hyperlipidemia 1357168 11374884 7 77531388 122402852 1 - by flanking markers 7 74244916 119494569 1 - by flanking markers 67935 1357345 WOKW DA/K 7 77428234 122421148 1 - by flanking markers 7 69736356 112729554 1 - by flanking markers 1357339 rat Stl14 Serum triglyceride level QTL 14 7 3.45 1.0E-4 33780 D7Mit1 34096 D7Mgh4 33670 D7Mit2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Hypertriglyceridemia;Metabolic Syndrome 1357168 11374884 7 122402980 141760721 1 - by flanking markers 7 119494698 141116327 1 - by flanking markers 67935 1357345 WOKW DA/K 7 122421276 143965415 1 - by flanking markers 7 112729683 133492707 1 - by flanking markers 1357340 rat Bp250 Blood pressure QTL 250 10 1.0E-4 631289 D10M11Mit119 631291 D10M11Mit84 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619625 9607182 10 100446517 112146223 4 - by one flank marker only 10 101848470 146848470 4 - by one flank marker only 631588 SS.MNS-(D10Mit11-Vamp2)/Mco 1357341 rat Gluco5 Glucose level QTL 5 4 6.4 11310 D4Bro1 adipocyte free fatty acid secretion trait (VT:0010465) absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446) abnormal circulating free fatty acids level Metabolic Syndrome;type 2 diabetes mellitus 61078 9171835 recessive 4 1 29789968 5 - by peak with adj size 4 1 28615362 5 - by peak with adj size 61096 61097 SHR/NCruk WKY/NCruk 4 1 29778604 5 - by peak with adj size 4 1 33250345 5 - by peak with adj size 1357342 rat Bw40 Body weight QTL 40 4 0.001 60732 D4Mit6 3753 Spr body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 69707 9530522 3197;3753 Npy;Spr 4 141978848 181496612 1 - by flanking markers 4 75732943 119369308 1 - by flanking markers 61107 1357346 BB/OK BB.SHR-(D4Mit6-Spr)/K 4 77307388 116916073 1 - by flanking markers 4 76647384 117676292 1 - by flanking markers 1357343 rat Gluco4 Glucose level QTL 4 4 2.0E-5 11310 D4Bro1 adipocyte glucose uptake trait (VT:0004185) adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874) abnormal adipocyte glucose uptake Metabolic Syndrome;type 2 diabetes mellitus 61078 9171835 recessive 4 1 29789968 5 - by peak with adj size 4 1 28615362 5 - by peak with adj size 61096 61097 SHR/NCruk WKY/NCruk 4 1 29778604 5 - by peak with adj size 4 1 33250345 5 - by peak with adj size 1357344 rat Bp249 Blood pressure QTL 249 10 1.0E-4 66552 D10Mco1 66563 D10Mco6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 619626 9096100 10 68786307 101157704 1 - by flanking markers 10 69986912 102587587 1 - by flanking markers 631587 631588 SS.MNS-(D10M11Mit119-D10Mit11)/Jr SS.MNS-(D10Mit11-Vamp2)/Mco 10 69123603 101482600 1 - by flanking markers 10 66743655 98003205 1 - by flanking markers 1357396 rat Bw44 Body weight QTL 44 5 4.19 34216 D5Mgh6 34041 D5Mit5 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1357168 11374884 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers 67935 1357345 WOKW DA/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 1357397 rat Bw41 Body weight QTL 41 1 4.19 1.0E-4 34662 D1Mgh2 33660 D1Mit9 33660 D1Mit9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1357168 11374884 1 24875821 50204515 1 - by flanking markers 1 22842898 43840628 1 - by flanking markers 67935 1357345 WOKW DA/K 1 23406428 49547474 1 - by flanking markers 1 22340647 49361612 1 - by flanking markers 1357398 rat Slep3 Serum leptin concentration QTL 3 8 3.43 33858 D8Mit4 33628 D8Mit6 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 1357168 11374884 8 11331573 44187546 1 - by flanking markers 8 9581375 44484215 1 - by flanking markers 67935 1357345 WOKW DA/K 8 11373509 45712344 1 - by flanking markers 8 9712463 41866876 1 - by flanking markers 1357399 rat Bw45 Body weight QTL 45 1 3.05 11060 D1Wox23 10674 D1Mgh12 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body weight Metabolic Syndrome;obesity 1357168 11374884 1 232642738 270717037 1 - by flanking markers 1 212121314 247322277 1 - by flanking markers 67935 1357345 WOKW DA/K 1 225689973 270689973 4 - by one flank marker only 1 206329708 251329708 4 - by one flank marker only 1357400 rat Bw62 Body weight QTL62 1 4.05 34662 D1Mgh2 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) increased total body fat amount obesity 1357168 11374884 1 24875821 69875821 4 - by one flank marker only 1 22842898 67842898 4 - by one flank marker only 67935 1357345 WOKW DA/K 1 23406428 68406428 4 - by one flank marker only 1 22340647 67340647 4 - by one flank marker only 1357401 rat Bw43 Body weight QTL 43 1 3.75 34662 D1Mgh2 33660 D1Mit9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1357168 11374884 1 24875821 50204515 1 - by flanking markers 1 22842898 43840628 1 - by flanking markers 67935 1357345 WOKW DA/K 1 23406428 49547474 1 - by flanking markers 1 22340647 49361612 1 - by flanking markers 1357402 rat Bw46 Body weight QTL 46 5 4.47 34216 D5Mgh6 34041 D5Mit5 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body weight Metabolic Syndrome;obesity 1357168 11374884 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers 67935 1357345 WOKW DA/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 1357403 rat Slep4 Serum leptin concentration QTL 4 16 3.91 33638 D16Mit4 10660 D16Mgh3 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level obesity 1357168 11374884 16 8979177 29485011 1 - by flanking markers 16 9964433 30560825 1 - by flanking markers 67935 1357345 WOKW DA/K 16 1 10660736 4 - by one flank marker only 16 1 9639137 4 - by one flank marker only 1357404 rat Bw42 Body weight QTL 42 1 4.49 1.0E-4 11060 D1Wox23 10674 D1Mgh12 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1357168 11374884 1 232642738 270717037 1 - by flanking markers 1 212121314 247322277 1 - by flanking markers 67935 1357345 WOKW DA/K 1 225689973 270689973 4 - by one flank marker only 1 206329708 251329708 4 - by one flank marker only 1357990 rat Ael1 Aortic elastin QTL 1 2 3.1 9.1E-4 9.2 43467 D2Got24 aorta elastin amount (VT:0003905) aortic elastin decreased aorta elastin content cardiovascular system disease 1334448 15668357 dominant 2 38074337 83074337 5 - by peak with adj size 2 18905511 63905511 5 - by peak with adj size 60985 1357985 BN LOU/Ins 2 19016465 64016465 5 - by peak with adj size 2 19076825 64076825 5 - by peak with adj size 1357991 rat Ael2 Aortic elastin QTL 2 2 4.2 7.1E-5 10201 D2Wox26 aorta elastin amount (VT:0003905) aortic elastin decreased aorta elastin content cardiovascular system disease 1334448 15668357 recessive 60985 1357985 BN LOU/Ins 1358185 rat Ept6 Estrogen-induced pituitary tumorigenesis QTL 6 3 6.7 11.0 41830 D3Rat277 34347 D3Mgh16 34186 D3Mgh9 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept17 (maps to same region) 3 11361817 31948244 1 - by flanking markers 3 6373454 22341164 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 3 571136 6000866 2 - by one flank and peak markers 3 6537645 10778823 2 - by one flank and peak markers 1358186 rat Ept2 Estrogen-induced pituitary tumorigenesis QTL 2 3 8.3 35451 D3Rat21 39050 D3Rat130 35795 D3Rat26 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept16 (maps to same region) 3 55227748 121789152 1 - by flanking markers 3 44551542 110215186 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 3 48562146 115249962 1 - by flanking markers 3 47233430 110362260 1 - by flanking markers 1358187 rat Emca1 Estrogen-induced mammary cancer QTL 1 5 4.4 36275 D5Rat57 35961 D5Rat53 36187 D5Rat30 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1358124;2291885;1642522 15611180;18057545;16885383 Emca8 (maps to same region) 5 106951761 158498929 1 - by flanking markers 5 103677659 155120876 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 5 102945579 154732228 1 - by flanking markers 5 99216724 148607142 1 - by flanking markers 1358188 rat Ept9 Estrogen-induced pituitary tumorigenesis QTL 9 10 3.9 7.0 35256 D10Rat11 36203 D10Rat27 33690 D10Mit7 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept18 (maps to same region) 10 74127968 99184058 1 - by flanking markers 10 77092169 100633512 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 10 75983805 99492217 1 - by flanking markers 10 73453136 96120911 1 - by flanking markers 1358189 rat Cstrr1 Cold stress response QTL 1 1 1.0E-4 60784 D1Wox29 11359 D1Arb21 catecholamine amount (VT:0010543) urine norepinephrine level (CMO:0001629) abnormal sensory capabilities/reflexes/nociception;increased circulating noradrenaline level;increased systemic arterial blood pressure autonomic nervous system disease;hypertension 1302892 15480093 Bp84 (sub_region) 1 131822204 206277202 1 - by flanking markers 1 124614679 187092492 1 - by flanking markers 1302636 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers 1358190 rat Ept1 Estrogen-induced pituitary tumorigenesis QTL 1 6 4.4 1357998 D6Rat150 35683 D6Rat39 37142 D6Rat80 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449;2292503 15687265;18420736 Ept15 (maps to same region) 6 8018013 31405507 1 - by flanking markers 6 1 8184962 2 - by one flank and peak markers 737892 1358153 ACI/SegHsd COP/CrCrl 6 8083222 21515439 1 - by flanking markers 6 9843312 20338915 1 - by flanking markers 1358191 rat Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 1 3.8 34971 D1Rat81 37294 D1Rat133 36083 D1Rat119 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449 15687265 1 217288730 272245217 1 - by flanking markers 1 197770157 250119666 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 1 210360774 264802828 1 - by flanking markers 1 192825253 243914732 1 - by flanking markers 1358192 rat Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 1 3.4 40964 D1Rat259 37688 D1Rat192 37688 D1Rat192 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1334449 15687265 1 25764938 79995195 1 - by flanking markers 1 23633441 77148378 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 1 24297799 78748000 1 - by flanking markers 1 77494165 122494165 4 - by one flank marker only 1358193 rat Emca2 Estrogen-induced mammary cancer QTL 2 18 1.6 37514 D18Rat43 36548 D18Rat27 36444 D18Rat21 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1358124;2291885;1642522 15611180;18057545;16885383 Emca7 (interacts with) 18 18780787 67591915 1 - by flanking markers 18 18562790 66652461 1 - by flanking markers 737892 1358153 ACI/SegHsd COP/CrCrl 18 19031030 68436105 1 - by flanking markers 18 18007599 63571040 1 - by flanking markers 1358200 rat Insglur2 Insulin/glucose ratio QTL 2 19 4.1 41262 D19Rat57 2993 Lcat blood glucose amount (VT:0000188) serum glucose level (CMO:0000543);serum insulin level (CMO:0000358) insulin resistance Insulin Resistance 619533 12016513 19 48783830 70892012 1 - by flanking markers 19 35784966 57234802 1 - by flanking markers 629499 BXS/Ipcv 19 37916799 60220451 1 - by flanking markers 19 33838214 55283146 1 - by flanking markers 1358201 rat Gluco12 Glucose level QTL12 4 1.6 35913 D4Rat10 10800 D4Wox27 10800 D4Wox27 adipocyte glucose uptake trait (VT:0004185) adipocyte maximal glucose uptake (CMO:0000870) abnormal glucose homeostasis;abnormal intestinal glucose absorption Insulin Resistance 1357415 15752738 4 3096419 26659360 1 - by flanking markers 4 460590 26280781 1 - by flanking markers 631286 631577 WKY/Izm SHR/Izm 4 3044114 26753655 1 - by flanking markers 4 5218392 29593287 1 - by flanking markers 1358202 rat Gluco11 Glucose level QTL 11 4 2.4 0.02 35409 D4Rat34 34338 D4Mgh11 11381 D4Mgh17 adipocyte glucose uptake trait (VT:0004185) absolute change in adipocyte glucose uptake (CMO:0000873) abnormal glucose homeostasis;abnormal intestinal glucose absorption Insulin Resistance 1357415 15752738 4 151090671 230565226 1 - by flanking markers 4 85014031 171204531 1 - by flanking markers 631286 631577 WKY/Izm SHR/Izm 4 86438317 168047091 1 - by flanking markers 4 85379421 167139601 1 - by flanking markers 1358203 rat Stl19 Serum triglyceride level QTL 19 4 2.8 0.002 10800 D4Wox27 38728 D4Rat122 35913 D4Rat10 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level;increased triglyceride level Hypertriglyceridemia;Metabolic Syndrome 1357415 15752738 4 3096322 64737743 1 - by flanking markers 4 460493 64750077 1 - by flanking markers 631286 631577 WKY/Izm SHR/Izm 4 3044017 64915903 1 - by flanking markers 4 5218294 65958103 1 - by flanking markers 1358204 rat Insglur1 Insulin/glucose ratio QTL 1 3 3.8 33608 D3Mit14 33927 D3Mit3 33808 D3Mit4 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543);serum insulin level (CMO:0000358) insulin resistance Insulin Resistance 619533 12016513 additive 3 129091119 148388048 1 - by flanking markers 3 115996080 136402080 1 - by flanking markers 629499 BXS/Ipcv 3 120917788 141971336 1 - by flanking markers 3 115638168 135181505 1 - by flanking markers 1358292 rat Cm37 Cardiac mass QTL 37 1 6.2 8.1E-7 17.5 36866 D1Rat73 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1334448 15668357 1 223613389 268613389 5 - by peak with adj size 1 201920676 246920676 5 - by peak with adj size 60985 1357985 BN LOU/Ins 1 216324817 261324817 5 - by peak with adj size 1 196248093 241248093 5 - by peak with adj size 1358293 rat Bw38 Body weight QTL 38 3 6.0 3.1E-6 18.6 1358021 D3Wox33 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;increased body weight 1334448 15668357 60985 1357985 BN LOU/Ins 3 56735995 101735995 5 - by peak with adj size 1358294 rat Bw37 Body weight QTL 37 1 5.0 1.1E-5 15.0 38940 D1Rat159 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight;increased body weight 1334448 15668357 1 195776722 240776722 5 - by peak with adj size 1 176292515 221292515 5 - by peak with adj size 60985 1357985 BN LOU/Ins 1 188850303 233850303 5 - by peak with adj size 1 171310381 216310381 5 - by peak with adj size 1358295 rat Aocep1 Aortic cell protein QTL 1 17 6.1 7.1E-7 16.1 45488 D17Got80 thoracic aorta cellular protein amount (VT:0010598) aortic cell percentage increased cell mass cardiovascular system disease 1334448 15668357 17 46097577 91097577 5 - by peak with adj size 17 51995423 96995423 5 - by peak with adj size 60985 1357985 BN LOU/Ins 17 44356157 89356157 5 - by peak with adj size 17 40990005 85990005 5 - by peak with adj size 1358296 rat Ael3 Aortic elastin QTL 3 14 3.7 5.1E-4 9.7 38932 D14Rat36 aorta elastin amount (VT:0003905) aortic elastin decreased aorta elastin content cardiovascular system disease 1334448 15668357 additive 14 10333529 55333529 5 - by peak with adj size 14 10539919 55539919 5 - by peak with adj size 60985 1357985 BN LOU/Ins 14 10539977 55539977 5 - by peak with adj size 14 8267090 53267090 5 - by peak with adj size 1358352 rat Srcrt3 Stress Responsive Cort QTL 3 4 2.29 35847 D4Rat12 36143 D4Rat60 38656 D4Rat128 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal corticosterone level 1598980 16895972 4 36467227 208908285 1 - by flanking markers 4 8819982 149560340 2 - by one flank and peak markers 61105 61109 WKY/NHsd F344/NHsd 4 36615599 145611886 1 - by flanking markers 4 38465774 146803430 1 - by flanking markers 1358353 rat Srcrtb2 Stress Responsive Cort Basal QTL 2 5 3.48 0.003 40716 D5Rat124 34144 D5Mgh11 40386 D5Rat131 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal corticosterone level 1598980;2312611 16895972;19697080 Gluco47 (maps to same region) 5 23635353 80745947 1 - by flanking markers 5 19206257 77484299 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 5 18847913 76608178 1 - by flanking markers 5 18873947 74251464 1 - by flanking markers 1358354 rat Srcrt5 Stress Responsive Cort QTL 5 15 3.38 39122 D15Rat40 35321 D15Rat27 38106 D15Rat50 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 1598980 16895972 15 108749721 111756589 2 - by one flank and peak markers 15 106152589 107060711 2 - by one flank and peak markers 61105 61109 WKY/NHsd F344/NHsd 15 105348517 108369033 2 - by one flank and peak markers 15 98150001 99043291 2 - by one flank and peak markers 1358355 rat Srcrt4 Stress Responsive Cort QTL 4 6 6.39 38634 D6Rat103 36191 D6Rat6 39650 D6Rat111 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) decreased circulating corticosterone level 1598980;10053640 16895972;21029000 1595901 Serpina6 Srcrt6 (maps to same region) 6 112535839 132488565 1 - by flanking markers 6 104481235 123455207 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 6 104363890 147991367 2 - by one flank and peak markers 6 100364669 140994061 2 - by one flank and peak markers 1358356 rat Srcrt1 Stress Responsive Cort QTL1 2 3.66 39076 D2Rat170 36962 D2Rat63 39118 D2Rat139 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) increased circulating corticosterone level 1598980 16895972 2 194748054 257699856 1 - by flanking markers 2 167857161 231465091 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 2 175403337 239166203 1 - by flanking markers 2 161699179 222436696 1 - by flanking markers 1358357 rat Srcrtb1 Stress Responsive Cort Basal QTL 1 3 6.36 0.002 34186 D3Mgh9 37010 D3Rat49 35054 D3Rat55 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) abnormal corticosterone level 1598980 16895972 3 8648011 33340453 1 - by flanking markers 3 4010230 23762628 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 3 3285929 28136884 1 - by flanking markers 3 8658162 27494778 1 - by flanking markers 1358358 rat Sradr6 Stress Responsive Adrenal Weight QTL 6 18 2.49 11461 D18Mit1 37412 D18Rat40 39444 D18Rat96 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 18 15314027 60695947 1 - by flanking markers 18 12406975 62106220 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 18 15539427 61499684 1 - by flanking markers 18 11944299 59330563 1 - by flanking markers 1358359 rat Sradr1 Stress Responsive Adrenal Weight QTL 1 1 4.74 34037 D1Mit1 36432 D1Rat35 35308 D1Rat24 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 1 27404590 131959064 2 - by one flank and peak markers 1 28716493 124749065 2 - by one flank and peak markers 61105 61109 WKY/NHsd F344/NHsd 1 25951907 130917265 2 - by one flank and peak markers 1 30882023 123479925 2 - by one flank and peak markers 1358360 rat Sradr2 Stress Responsive Adrenal Weight QTL 2 2 10.24 38960 D2Rat93 38522 D2Rat164 41152 D2Rat220 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 2 152901512 192362483 1 - by flanking markers 2 133459258 157917105 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 2 133399373 173020198 1 - by flanking markers 2 129164097 152195315 1 - by flanking markers 1358361 rat Sradr5 Stress Responsive Adrenal Weight QTL 5 7 5.55 42215 D7Arb16 39144 D7Rat88 36731 D7Rat24 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980;2312611 16895972;19697080 Gluco53 (maps to same region) 7 51264830 118470274 1 - by flanking markers 7 47145687 114883369 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 7 51251919 118477612 1 - by flanking markers 7 43747012 108555253 1 - by flanking markers 1358362 rat Srcrt2 Stress Responsive Cort QTL 2 3 2.78 37510 D3Rat100 41228 D3Rat152 41162 D3Rat181 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) decreased circulating corticosterone level 1598980;2312611 16895972;19697080 Gluco46 (maps to same region) 3 44344790 146691568 1 - by flanking markers 3 35237920 134686096 1 - by flanking markers 61105 61109 WKY/NHsd F344/NHsd 3 39248391 140271184 1 - by flanking markers 3 38192233 133483320 1 - by flanking markers 1358363 rat Sradr3 Stress Responsive Adrenal Weight QTL 3 4 6.19 38656 D4Rat128 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 4 122835386 167835386 5 - by peak with adj size 4 56690161 101690161 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 4 58166424 103166424 5 - by peak with adj size 4 57486946 102486946 5 - by peak with adj size 1358364 rat Sradr4 Stress Responsive Adrenal Weight QTL 4 4 4.92 39054 D4Rat137 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) abnormal adrenal gland morphology 1598980 16895972 4 194518814 239518814 5 - by peak with adj size 4 132846974 177846974 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 4 128602727 173602727 5 - by peak with adj size 1358885 rat Bp251 Blood pressure QTL 251 3 3.8 0.06 35617 D3Rat54 36717 D3Rat17 40122 D3Rat186 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 3 15999179 133513825 1 - by flanking markers 3 10267741 121619110 1 - by flanking markers 60999 1302795 LEW HTG 3 10639528 127023997 1 - by flanking markers 3 14489145 121056321 1 - by flanking markers 1358886 rat Bp260 Blood pressure QTL 260 1 3.67 43423 D1Got228 38564 D1Rat140 36757 D1Rat71 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 1 167997883 253469877 1 - by flanking markers 1 154075310 231726050 1 - by flanking markers 60999 1302795 LEW HTG 1 161784422 246226103 1 - by flanking markers 1 151162766 225824951 1 - by flanking markers 1358887 rat Bw50 Body weight QTL 50 2 2.39 36213 D2Rat40 38576 D2Rat182 35250 D2Rat13 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386;61058 14640890;9329963 2 43009608 189197858 1 - by flanking markers 2 24474676 163154227 1 - by flanking markers 60999 1302795 LEW HTG 2 23837719 169852670 1 - by flanking markers 2 25413652 157142078 1 - by flanking markers 1358888 rat Bp264 Blood pressure QTL 264 3 4.43 35617 D3Rat54 36717 D3Rat17 34146 D3Mgh6 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 3 15999179 133513825 1 - by flanking markers 3 10267741 121619110 1 - by flanking markers 60999 1302795 LEW HTG 3 10639528 127023997 1 - by flanking markers 3 14489145 121056321 1 - by flanking markers 1358889 rat Bp261 Blood pressure QTL 261 5 2.86 37242 D5Rat77 38338 D5Rat108 60808 D5Wox25 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 5 97128212 137108002 2 - by one flank and peak markers 5 94084025 134872385 2 - by one flank and peak markers 60999 1302795 LEW HTG 5 93037304 133313852 2 - by one flank and peak markers 5 90067849 128034027 2 - by one flank and peak markers 1358890 rat Bp259 Blood pressure QTL 259 1 3.06 36757 D1Rat71 10674 D1Mgh12 41418 D1Rat304 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 1 237556833 270717037 1 - by flanking markers 1 216662939 247322277 1 - by flanking markers 60999 1302795 LEW HTG 1 230420627 282645769 2 - by one flank and peak markers 1 210702053 260522016 2 - by one flank and peak markers 1358891 rat Bp265 Blood pressure QTL 265 7 2.21 39938 D7Rat141 39652 D7Rat115 40784 D7Rat135 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 7 92475985 142937382 1 - by flanking markers 7 88583730 142441286 1 - by flanking markers 60999 1302795 LEW HTG 7 91832949 145158140 1 - by flanking markers 7 83591953 134666232 1 - by flanking markers 1358892 rat Kidm26 Kidney mass QTL 26 8 3.69 41522 D8Rat164 11222 D8Mgh3 36235 D8Rat35 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 8 29878681 105968579 1 - by flanking markers 8 28414004 103684785 1 - by flanking markers 60999 1302795 LEW HTG 8 29867983 106526740 1 - by flanking markers 8 27205715 99103503 1 - by flanking markers 1358893 rat Bp263 Blood pressure QTL 263 8 5.01 36904 D8Rat19 38484 D8Rat171 37072 D8Rat59 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) hypertension 1303386 14640890 8 100352377 131417183 1 - by flanking markers 8 98451122 127956046 1 - by flanking markers 60999 1302795 LEW HTG 8 100873811 133307652 4 - by one flank marker only 8 93965141 123900184 4 - by one flank marker only 1358894 rat Kidm24 Kidney mass QTL 24 2 4.03 38576 D2Rat182 36213 D2Rat40 38576 D2Rat182 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358895 rat Bp254 Blood pressure QTL 254 5 3.6 3.0E-4 36177 D5Rat9 38338 D5Rat108 41424 D5Rat156 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389;2316920 12545249;19556729 5 64593776 137108002 1 - by flanking markers 5 61080077 134872385 1 - by flanking markers 60999 1302795 LEW HTG 5 60072951 133313852 1 - by flanking markers 5 58829236 128034027 1 - by flanking markers 1358896 rat Bp262 Blood pressure QTL 262 8 2.89 41522 D8Rat164 11222 D8Mgh3 36235 D8Rat35 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure hypertension 1303386 14640890 8 29878681 105968579 1 - by flanking markers 8 28414004 103684785 1 - by flanking markers 60999 1302795 LEW HTG 8 29867983 106526740 1 - by flanking markers 8 27205715 99103503 1 - by flanking markers 1358897 rat Stresp6 Stress response QTL 6 10 4.17 0.022 10.2 33909 D10Mit4 34648 D10Mgh14 10949 D10Wox11 blood norepinephrine amount (VT:0005663) plasma norepinephrine level (CMO:0001010) increased circulating noradrenaline level 1332590 15547139 dominant 10 36354729 65109346 1 - by flanking markers 10 36649906 65379965 1 - by flanking markers 1302795 1354669 HTG BN/OrlIcoCrlf 10 36584373 66539843 1 - by flanking markers 10 35392267 64155584 1 - by flanking markers 1358898 rat Bp255 Blood pressure QTL 255 1 3.6 37732 D1Rat208 41060 D1Rat307 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 1 215445861 274378630 1 - by flanking markers 1 195927908 252497797 1 - by flanking markers 60999 1302795 LEW HTG 1 208517798 266948272 1 - by flanking markers 1 191019702 246062233 1 - by flanking markers 1358899 rat Kidm23 Kidney mass QTL 23 2 3.88 38576 D2Rat182 36213 D2Rat40 41538 D2Rat199 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358900 rat Bw48 Body weight QTL 48 2 4.88 35915 D2Rat61 36213 D2Rat40 34234 D2Mgh9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 2 88594475 189197988 1 - by flanking markers 2 163154358 227150051 1 - by flanking markers 60999 1302795 LEW HTG 2 68865414 169852800 1 - by flanking markers 2 157142078 211086598 2 - by one flank and peak markers 1358901 rat Cm38 Cardiac mass QTL 38 2 2.0 38576 D2Rat182 36213 D2Rat40 39512 D2Rat210 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358902 rat Bw47 Body weight QTL 47 1 1.67 36765 D1Rat27 36592 D1Rat64 38564 D1Rat140 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 1 95301716 204172352 1 - by flanking markers 1 90282040 184857893 1 - by flanking markers 60999 1302795 LEW HTG 1 94201400 197187904 1 - by flanking markers 1 90508614 180359386 1 - by flanking markers 1358903 rat Bp252 Blood pressure QTL 252 8 7.0 1.0E-4 36904 D8Rat19 38484 D8Rat171 37072 D8Rat59 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 8 100352377 131417183 1 - by flanking markers 8 98451122 127956046 1 - by flanking markers 60999 1302795 LEW HTG 8 100873811 133307652 4 - by one flank marker only 8 93965141 123900184 4 - by one flank marker only 1358904 rat Cm39 Cardiac mass QTL 39 2 2.26 38576 D2Rat182 36213 D2Rat40 41538 D2Rat199 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358905 rat Hrtrt17 Heart rate QTL 17 3 5.9 1.4E-5 10293 D3Mit7 34198 D3Mgh8 3632 Scn2a heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 1358133 9286932 2958;3632 Kcnj3;Scn2a 3 16721683 100057615 2 - by one flank and peak markers 3 6662627 88648585 2 - by one flank and peak markers 61010 61103 SHRSP WKY 3 10094081 93415837 2 - by one flank and peak markers 3 10861912 89878372 2 - by one flank and peak markers 1358906 rat Bp253 Blood pressure QTL 253 8 4.0 4.0E-4 36117 D8Rat46 36904 D8Rat19 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303389 12545249 8 61319409 100352529 1 - by flanking markers 8 43313902 98451660 1 - by flanking markers 60999 1302795 LEW HTG 8 44219197 100873963 1 - by flanking markers 8 40713066 93965294 1 - by flanking markers 1358907 rat Cm40 Cardiac mass QTL 40 8 1.89 41522 D8Rat164 11222 D8Mgh3 41522 D8Rat164 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 8 29878681 105968579 1 - by flanking markers 8 28414004 103684785 1 - by flanking markers 60999 1302795 LEW HTG 8 29867983 106526740 1 - by flanking markers 8 27205715 99103503 1 - by flanking markers 1358908 rat Bw49 Body weight QTL 49 2 3.36 36213 D2Rat40 38576 D2Rat182 34005 D2Mit8 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 2 43009608 189197858 1 - by flanking markers 2 24474676 163154227 1 - by flanking markers 60999 1302795 LEW HTG 2 23837719 169852670 1 - by flanking markers 2 25413652 157142078 1 - by flanking markers 1358909 rat Kidm25 Kidney mass QTL 25 5 1.87 37242 D5Rat77 38338 D5Rat108 60808 D5Wox25 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight hypertension 1303386 14640890 5 97128212 137108002 2 - by one flank and peak markers 5 94084025 134872385 2 - by one flank and peak markers 60999 1302795 LEW HTG 5 93037304 133313852 2 - by one flank and peak markers 5 90067849 128034027 2 - by one flank and peak markers 1358910 rat Kidm27 Kidney mass QTL 27 2 5.77 38576 D2Rat182 36213 D2Rat40 35272 D2Rat19 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358911 rat Kidm28 Kidney mass QTL 28 2 5.42 38576 D2Rat182 36213 D2Rat40 38576 D2Rat182 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight;increased kidney weight hypertension 1303386 14640890 2 43009380 189197988 1 - by flanking markers 2 24474447 163154358 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 169852800 1 - by flanking markers 2 25413423 157142209 1 - by flanking markers 1358912 rat Bw51 Body weight QTL 51 8 2.95 35388 D8Rat37 37072 D8Rat59 39574 D8Rat139 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 1303386 14640890 8 54031714 115113003 1 - by flanking markers 8 54364071 112242906 1 - by flanking markers 60999 1302795 LEW HTG 8 55435004 115812386 2 - by one flank and peak markers 8 51351728 107062046 2 - by one flank and peak markers 1358913 rat Cm41 Cardiac mass QTL 41 2 2.73 38576 D2Rat182 35693 D2Rat55 38266 D2Rat136 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 237043265 1 - by flanking markers 2 24474447 212169089 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 218957222 1 - by flanking markers 2 25413423 203928301 1 - by flanking markers 1358914 rat Bp266 Blood pressure QTL 266 7 39938 D7Rat141 39652 D7Rat115 35681 D7Rat5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1303386 14640890 7 92475985 142937382 1 - by flanking markers 7 88583730 142441286 1 - by flanking markers 60999 1302795 LEW HTG 7 91832949 145158140 1 - by flanking markers 7 83591953 134666232 1 - by flanking markers 1358915 rat Stresp7 Stress response QTL 7 10 3.52 9.6 34718 D10Mgh23 11308 D10Wox20 11308 D10Wox20 blood norepinephrine amount (VT:0005663) plasma norepinephrine level (CMO:0001010) increased circulating noradrenaline level 1332590 15547139 codominant 10 81479737 90085597 1 - by flanking markers 10 68955627 110718848 5 - by peak with adj size 1302795 1354669 HTG BN/OrlIcoCrlf 10 81649775 90297007 1 - by flanking markers 10 78899655 87307728 1 - by flanking markers 1358916 rat Kidm22 Kidney mass QTL 22 1 3.32 36757 D1Rat71 10674 D1Mgh12 43423 D1Got228 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight hypertension 1303386 14640890 1 237556833 270717037 1 - by flanking markers 1 216662939 247322277 1 - by flanking markers 60999 1302795 LEW HTG 1 230420627 262031693 2 - by one flank and peak markers 1 210702053 240947965 2 - by one flank and peak markers 1358917 rat Cm42 Cardiac mass QTL 42 2 2.82 38576 D2Rat182 35693 D2Rat55 41538 D2Rat199 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly 1303386 14640890 2 43009380 237043265 1 - by flanking markers 2 24474447 212169089 1 - by flanking markers 60999 1302795 LEW HTG 2 23837491 218957222 1 - by flanking markers 2 25413423 203928301 1 - by flanking markers 1359017 rat Hrtrt21 Heart rate QTL 21 10 2.4 36319 D10Rat26 42373 D10Rat267 40788 D10Rat145 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 625381 11882571 10 54914324 99914324 4 - by one flank marker only 10 68526078 101292630 2 - by one flank and peak markers Recombinant inbred 61098 61099 BXH/Ipcv HXB/Ipcv 10 55224855 100224855 4 - by one flank marker only 10 51772940 96772940 4 - by one flank marker only 1359018 rat Hrtrt20 Heart rate QTL 20 1 3.08 41012 D1Rat287 41110 D1Rat292 36460 D1Rat69 heart pumping trait (VT:2000009) heart rate (CMO:0000002) increased heart rate heart disease 625381 11882571 1 208389496 228799992 2 - by one flank and peak markers 1 190114247 208110419 2 - by one flank and peak markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 1 201358068 221983732 2 - by one flank and peak markers 1 185356336 202902618 2 - by one flank and peak markers 1359019 rat Hrtrt19 Heart rate QTL 19 2 2.9 35849 D2Rat62 41066 D2Rat247 36962 D2Rat63 heart pumping trait (VT:2000009) heart rate (CMO:0000002) decreased heart rate Bradycardia;heart disease 625381 11882571 2 254867191 261576629 1 - by flanking markers 2 228663949 234266109 2 - by one flank and peak markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 2 236318496 243026643 1 - by flanking markers 2 219753301 226277316 1 - by flanking markers 1359020 rat Ppulsi2 Prepulse inhibition QTL 2 18 2.71 37738 D18Rat57 35282 D18Rat5 prepulse inhibition trait (VT:0003088) acoustic startle response measurement (CMO:0001519) abnormal prepulse inhibition schizophrenia 629579 12426667 18 53100479 76260776 1 - by flanking markers 18 54605732 77452533 1 - by flanking markers 10008 1358112 BN/SsNHsd WKY/NCrl 18 53861252 77151443 1 - by flanking markers 18 52292875 73997283 1 - by flanking markers 1359021 rat Bp271 Blood pressure QTL 271 8 1.8 34723 D8Mgh9 37038 D8Rat40 42849 D8Rat219 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure hypertension 625381 11882571 8 29548704 49334354 2 - by one flank and peak markers 8 27021985 49403011 2 - by one flank and peak markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 8 28168023 50708951 2 - by one flank and peak markers 8 26644912 46711092 2 - by one flank and peak markers 1359022 rat Ppulsi1 Prepulse inhibition QTL 1 2 3.63 36466 D2Rat34 36876 D2Rat88 prepulse inhibition trait (VT:0003088) acoustic startle response measurement (CMO:0001519) abnormal prepulse inhibition schizophrenia 629579 12426667 2 161739948 248335979 1 - by flanking markers 2 141755026 222281918 1 - by flanking markers 10008 1358112 BN/SsNHsd WKY/NCrl 2 142053350 228984665 1 - by flanking markers 2 136916935 213594495 1 - by flanking markers 1359023 rat Bp272 Blood pressure QTL 272 6 2.5 37142 D6Rat80 42778 D6Rat171 37142 D6Rat80 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure hypertension 625381 11882571 6 1111498 38512233 1 - by flanking markers 6 1301952 27253998 1 - by flanking markers recombinantinbred 61098 61099 BXH/Ipcv HXB/Ipcv 6 1120393 28706721 1 - by flanking markers 6 16536140 27261739 1 - by flanking markers 1359030 rat Bp277 Blood pressure QTL 277 2 38362 D2Rat161 10712 D2Mgh10 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure hypertension 629618 12209022 2 138120195 219929405 1 - by flanking markers 2 118264490 163264490 4 - by one flank marker only 1358992 SHR.WKY-(D2Rat40-D2Rat50) 2 118446646 200453484 1 - by flanking markers 2 114837527 185876470 1 - by flanking markers 1359031 rat Bp275 Blood pressure QTL 275 2 10712 D2Mgh10 35849 D2Rat62 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 629618 12209022 2 219929245 254867363 1 - by flanking markers 2 183664122 228664122 4 - by one flank marker only 1359001 WKY.SHR-(D2Rat42-D2Rat139) 2 200453324 236318668 1 - by flanking markers 2 185876309 219753474 1 - by flanking markers 1359032 rat Hrtrt18 Heart rate QTL 18 2 36213 D2Rat40 36773 D2Rat50 heart pumping trait (VT:2000009) heart rate (CMO:0000002) abnormal heart rate;decreased heart rate Bradycardia;heart disease 629618 12209022 2 189197858 227035367 1 - by flanking markers 2 163154227 200390471 1 - by flanking markers 1358992 SHR.WKY-(D2Rat40-D2Rat50) 2 169852670 207612467 1 - by flanking markers 2 157142078 192625452 1 - by flanking markers 1359033 rat Bp273 Blood pressure QTL 273 8 33559 D8Mit5 34415 D8Mgh6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) abnormal touch/ nociception;decreased systemic arterial blood pressure hypertension 1358955 12388796 2345;2347;2351 Chrna3;Chrna5;Chrnb4 8 33603024 65467051 1 - by flanking markers 8 32203394 64762616 1 - by flanking markers 61106 SHR.BN-(D8Mit5-D8Mgh6)/Ipcv 8 33558660 65717592 1 - by flanking markers 8 30848154 61290444 1 - by flanking markers 1359034 rat Bp274 Blood pressure QTL 274 2 35643 D2Rat21 35148 D2Rat27 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 629618 12209022 2 95410090 116297798 1 - by flanking markers 2 75806326 96482076 1 - by flanking markers 1358999 WKY.SHR-(D2Rat174-D2Rat28) 2 75687495 96556760 1 - by flanking markers 2 74786664 94359546 1 - by flanking markers 1359035 rat Bp276 Blood pressure QTL 276 2 38362 D2Rat161 34005 D2Mit8 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure hypertension 629618 12209022 2 138120195 169047413 1 - by flanking markers 2 118264490 148790758 1 - by flanking markers 1359006 WKY.SHR-(D2Rat27-D2Rat243) 2 118446646 149614623 1 - by flanking markers 2 114837527 143657569 1 - by flanking markers 1549827 rat Scl46 Serum cholesterol level QTL 46 4 3.5 42147 D4Arb15 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 4 198947905 243947905 5 - by peak with adj size 4 135601855 180601855 5 - by peak with adj size 1302711 1549801 ExHC/Seac BN/Seac 4 131864442 176864442 5 - by peak with adj size 4 132396220 177396220 5 - by peak with adj size 1549828 rat Bp258 Blood pressure QTL 258 2 0.03 1358052 D2Chm90 1358031 D2Chm225 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1357413;1599557;7421500;7421631 15738349;17143582;23814039;19461651 Bp310 (interacts with);Bp346 (interacts with);Bp368 (sub_region) 2 167706439 177627084 1 - by flanking markers 2 147424195 156267340 1 - by flanking markers 1358165 SS.MNS-(D2Chm51-D2Rat341)/Ayd 2 148295267 158268703 1 - by flanking markers 2 142323368 150650069 1 - by flanking markers 1549829 rat Scl48 Serum cholesterol level QTL 48 12 5.0 37830 D12Rat36 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 12 16892812 54450796 5 - by peak with adj size 12 10716230 46782294 5 - by peak with adj size 1302711 1549801 ExHC/Seac BN/Seac 12 15021986 52716770 5 - by peak with adj size 12 9603277 46669029 5 - by peak with adj size 1549830 rat Bss1 Bone structure and strength QTL 1 1 4.8 40534 D1Rat291 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) abnormal bone strength bone disease 1549683 16059631 1 197197749 242197749 5 - by peak with adj size 1 177666790 222666790 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 1 190282646 235282646 5 - by peak with adj size 1 172609619 217609619 5 - by peak with adj size 1549831 rat Bss6 Bone structure and strength QTL 6 10 4.0 41170 D10Rat146 lumbar vertebra strength trait (VT:0010574) vertebra ultimate force (CMO:0001678) abnormal bone strength bone disease 1549683 16059631 10 60260619 105260619 5 - by peak with adj size 10 61314296 106314296 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 10 60450007 105450007 5 - by peak with adj size 10 57576521 102576521 5 - by peak with adj size 1549832 rat Bss3 Bone structure and strength QTL 3 4 11.0 35070 D4Rat57 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure bone disease 1549683 16059631 4 174127594 219127594 5 - by peak with adj size 4 112039347 157039347 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 4 109636356 154636356 5 - by peak with adj size 4 109827074 154827074 5 - by peak with adj size 1549833 rat Bp257 Blood pressure QTL 257 2 0.003 2613 Fgg 1358039 D2Chm57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1357413;1599557;7421500;7421631 15738349;17143582;23814039;19461651 Bp279 (interacts with);Bp310 (interacts with);Bp363 (sub_region);Bp364 (sub_region);Bp365 (sub_region) 2 201401700 219177325 1 - by flanking markers 2 174727312 192363025 1 - by flanking markers 1358169 SS.MNS-(D2Chm25-D2Rat131)/Ayd 2 181987080 199696953 1 - by flanking markers 2 168354880 185122374 1 - by flanking markers 1549834 rat Scl45 Serum cholesterol level QTL 45 14 5.8 41406 D14Rat88 40140 D14Rat95 38070 D14Rat43 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851;2300117 16061941;18753676 Scl59 (sub_region) 14 65509916 104803539 1 - by flanking markers 14 66611911 101647208 1 - by flanking markers 1302711 1549801 ExHC/Seac BN/Seac 14 51818462 105074364 2 - by one flank and peak markers 14 50023211 95023211 4 - by one flank marker only 1549835 rat Tcas7 Tongue tumor susceptibility QTL 7 19 0.001 11472 D19Wox8 10418 D19Mit6 tongue integrity trait (VT:0010553) squamous cell carcinoma of the head and neck tumor number (CMO:0001876) increased tongue tumor incidence Tongue Neoplasms 1358147 15876484 Tcas1 (sub_region) 19 35433730 54715514 1 - by flanking markers 19 26536747 41612881 1 - by flanking markers 1358921 WF.DA-(D19Mit1-D19Mit6)/Kop 19 24455726 43907843 1 - by flanking markers 19 24817978 39654489 1 - by flanking markers 1549836 rat Bss2 Bone structure and strength QTL 2 2 7.5 34864 D2Rat67 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone strength;abnormal bone structure bone disease 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 1549837 rat Hcar15 Hepatocarcinoma resistance QTL 15 1 0.05 34074 D1Mgh8 10674 D1Mgh12 36866 D1Rat73 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) decreased apoptosis;decreased hepatoma incidence;decreased liver tumor incidence Experimental Liver Neoplasms 1358145 15771619 1 169999389 270717037 1 - by flanking markers 1 156124624 247322277 1 - by flanking markers 2304125 DRH.F344-(D1Mgh8-D1Mgh12)/Shigm 1 163796316 282763074 2 - by one flank and peak markers 1 153136852 260522016 2 - by one flank and peak markers 1549838 rat Bss4 Bone structure and strength QTL 4 5 9.2 35060 D5Rat29 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone strength;abnormal bone structure bone disease 1549683 16059631 3001 Lepr 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 1549839 rat Bw52 Body weight QTL 52 4 1.0E-4 43802 D4Got41 3811 Tacr1 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight obesity 1358143 15833945 628871 Gimap5 4 60179409 178095041 1 - by flanking markers 4 60262965 116780394 1 - by flanking markers 1357980 BB.SHR-(D4Got41-Tacr1)/K 4 60439127 113416139 1 - by flanking markers 4 61697658 115089733 1 - by flanking markers 1549840 rat Bss5 Bone structure and strength QTL 5 7 9.8 37236 D7Rat51 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure bone disease 1549683 16059631 7 32058288 77058288 5 - by peak with adj size 7 28333735 73333735 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 7 32035053 77035053 5 - by peak with adj size 7 24751841 69751841 5 - by peak with adj size 1549841 rat Bp256 Blood pressure QTL 256 2 0.03 1358030 D2Chm33 1358052 D2Chm90 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1357413;1599557;7421500;7421631 15738349;17143582;23814039;19461651 Bp279 (interacts with);Bp310 (interacts with);Bp345 (interacts with);Bp367 (sub_region) 2 162041036 167706680 1 - by flanking markers 2 142068645 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 142355464 148295508 1 - by flanking markers 2 137219876 142323610 1 - by flanking markers 1549842 rat Bp248 Blood pressure QTL 248 16 0.01 36892 D16Rat12 1358042 D16Chm66 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure hypertension 1300037 15080379 Bp75 (sub_region) 16 1084304 3406223 1 - by flanking markers 16 350121 3080985 1 - by flanking markers 1358168 SS.LEW-(D16Mit2-D16Chm23)/Ayd 16 1090054 3439762 1 - by flanking markers 16 380245 2995463 1 - by flanking markers 1549843 rat Bw53 Body weight QTL 53 4 1.0E-4 43802 D4Got41 2590 Fabp1 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight obesity 1358143 15833945 628871 Gimap5 4 60179409 163844105 1 - by flanking markers 4 60262965 104415981 1 - by flanking markers 1358922 BB.WOKW-(D4Got41-Fabp1)/K 4 60439127 99066957 1 - by flanking markers 4 61697658 103194791 1 - by flanking markers 1549844 rat Bss7 Bone structure and strength QTL 7 15 6.4 40516 D15Rat106 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure bone disease 1549683 16059631 15 87444850 114627140 5 - by peak with adj size 15 83677810 109758846 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 15 84050550 111246239 5 - by peak with adj size 15 75788062 101769107 5 - by peak with adj size 1549845 rat Scl44 Serum cholesterol level QTL 44 5 6.0 41350 D5Rat132 36275 D5Rat57 37950 D5Rat95 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 5 45401839 158499076 1 - by flanking markers 5 41498818 155121024 1 - by flanking markers 1302711 1549801 ExHC/Seac BN/Seac 5 40777918 154732375 1 - by flanking markers 5 40128307 148607290 1 - by flanking markers 1549846 rat Scl47 Serum cholesterol level QTL 47 10 3.6 36751 D10Rat25 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Hypercholesterolemia 1547851 16061941 10 52002683 97002683 5 - by peak with adj size 10 54091148 99091148 5 - by peak with adj size 1302711 1549801 ExHC/Seac BN/Seac 10 53104718 98104718 5 - by peak with adj size 10 50574707 95574707 5 - by peak with adj size 1549847 rat Bss8 Bone structure and strength QTL 8 19 4.0 38432 D19Rat32 lumbar vertebra strength trait (VT:0010574) vertebra ultimate force (CMO:0001678) abnormal bone strength bone disease 1549683 16059631 19 1 32364000 5 - by peak with adj size 19 1 32421352 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 19 1 32379055 5 - by peak with adj size 19 1 31963836 5 - by peak with adj size 1549848 rat Bvd6 Brain ventricular dilatation QTL 6 11 3.1 1.0E-4 4.5 39084 D11Rat93 41692 D11Rat89 37942 D11Rat46 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) hydrocephaly hydrocephalus 68693;68196 11178739;11178739 3761 Sst Bvd3 (sub_region) 11 72432813 89414405 1 - by flanking markers 11 67930910 87759784 2 - by one flank and peak markers 60994 68189 F344 HTX/Hcj 11 69342319 86312439 1 - by flanking markers 11 66113321 82169223 1 - by flanking markers 1549897 rat Stresp12 Stress response QTL 12 13 3.35 3.4 38396 D13Rat77 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 additive 13 48547327 93547327 5 - by peak with adj size 13 40675437 85675437 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 13 43575717 88575717 5 - by peak with adj size 13 38433408 83433408 5 - by peak with adj size 1549898 rat Neuinf3 Neuroinflammation QTL 3 10 26.4 59985 D10Got6 33591 D10Mit14 34361 D10Mgh25 nervous system integrity trait (VT:0010566) MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980) abnormal level of surface class II molecules autoimmune disease of the nervous system 1358146;1358788 15821736;14586010 619813 Ciita additive Neuinf2 (sub_region) 10 1728277 4281241 1 - by flanking markers 10 3219701 5339859 1 - by flanking markers 737658 737950 PVG.1AV1 DA/Ztm 10 2847625 5460218 1 - by flanking markers 10 3406320 5387112 1 - by flanking markers 1549899 rat Stresp8 Stress response QTL 8 7 4.37 8.0E-4 0.5 37360 D7Rat68 stress-related behavior trait (VT:0010451) defensive burying duration (CMO:0001961) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 7 100168740 143501887 5 - by peak with adj size 7 97285400 142285400 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 7 100192194 145192194 5 - by peak with adj size 7 90482196 135012528 5 - by peak with adj size 1549900 rat Iddm20 Insulin dependent diabetes mellitus QTL 20 17 3.7 38992 D17Rat61 40000 D17Rat115 pancreas integrity trait (VT:0010560) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) autoimmune response;hyperglycemia Experimental Diabetes Mellitus 1358924;2313174 15793267;19720792 3796 Syk incomplete_dominance 17 16076494 25280219 1 - by flanking markers 17 19877005 27819082 1 - by flanking markers 1304487 1359010 BBDR/Wor WF.BBDR-ART2a/Wor 17 14009679 23316697 1 - by flanking markers 17 13986773 21975515 1 - by flanking markers 1549901 rat Neudeg2 Neurodegradation QTL 2 5 4.0 0.0 39160 D5Rat73 38548 D5Rat82 39186 D5Rat70 nervous system integrity trait (VT:0010566) mononuclear cell count (CMO:0002119) decreased motor neuron number;increased double-negative T cell number central nervous system disease;neurodegenerative disease 1358788;1358768;2317162 14586010;15894332;19526058 additive Neudeg1 (interacts with) 5 29676862 49366257 1 - by flanking markers 5 25602274 45822846 1 - by flanking markers 629486 737950 PVG/OlaHsd DA/Ztm 5 24956212 44747071 1 - by flanking markers 5 24838710 44045280 1 - by flanking markers 1549902 rat Bp269 Blood pressure QTL 269 12 41962 D12Arb6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial diastolic blood pressure hypertension 1358144 15809361 12 20650729 54450796 5 - by peak with adj size 12 14356765 46782294 5 - by peak with adj size 69369 631576 SS LEW/CrlCrlj 12 18752593 52716770 5 - by peak with adj size 12 13182736 46669029 5 - by peak with adj size 1549903 rat Bp267 Blood pressure QTL 267 1 10333 D1Arb33 34381 D1Mgh7 36765 D1Rat27 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial diastolic blood pressure;increased systemic arterial systolic blood pressure hypertension 1358144 15809361 3175;1306420 Klk1b3;Klk7 1 80380367 114601028 1 - by flanking markers 1 77541583 106445306 1 - by flanking markers 69369 631576 SS LEW/CrlCrlj 1 79134941 113593716 1 - by flanking markers 1 77876254 106047988 1 - by flanking markers 1549904 rat Neuinf1 Neuroinflammation QTL 1 5 3.0 0.0 41492 D5Rat178 41798 D5Rat246 35823 D5Rat50 nervous system integrity trait (VT:0010566) blood T lymphocyte count (CMO:0000110) increased double-negative T cell number central nervous system disease 1358788;1358768 14586010;15894332 additive 5 164789054 177180328 2 - by one flank and peak markers 5 161449395 173096209 4 - by one flank marker only 629486 737950 PVG/OlaHsd DA/Ztm 5 161084664 173707219 2 - by one flank and peak markers 5 154828214 166875058 2 - by one flank and peak markers 1549905 rat Stresp10 Stress response QTL 10 6 6.83 0.0066 2.7 35963 D6Rat46 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 Bp141 (maps to same region);Despr12 (maps to same region) 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 1549907 rat Neuinf2 Neuroinflammation QTL 2 10 27.0 0.0 37464 D10Rat95 38062 D10Rat96 nervous system integrity trait (VT:0010566) MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980) abnormal level of surface class II molecules Experimental Autoimmune Encephalomyelitis;autoimmune disease of the nervous system 1358146;1358788;1358768;7242893 15821736;14586010;15894332;18292553 additive Neuinf3 (sub_region) 10 5044836 5243736 1 - by flanking markers 10 6172805 6380753 1 - by flanking markers 629486 737950 PVG/OlaHsd DA/Ztm 10 6229289 6429075 1 - by flanking markers 10 6154377 6357896 1 - by flanking markers 1549908 rat Neudeg1 Neurodegradation QTL 1 8 5.5 0.0 37742 D8Rat163 40736 D8Rat129 41794 D8Rat205 nervous system integrity trait (VT:0010566) logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986) decreased motor neuron number;motor neuron degeneration neurodegenerative disease 1358768;1358788;2317162 15894332;14586010;19526058 additive Neudeg2 (interacts with) 8 32911182 100850022 1 - by flanking markers 8 31508524 98947320 1 - by flanking markers 629486 737950 PVG/OlaHsd DA/Ztm 8 32888352 101374135 1 - by flanking markers 8 30188867 94457446 1 - by flanking markers 1549909 rat Stresp11 Stress response QTL 11 8 6.83 0.0019 2.1 37818 D8Rat66 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 Activ1 (maps to same region) 8 80157100 125157100 5 - by peak with adj size 8 78008525 123008525 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 8 80697934 125697934 5 - by peak with adj size 8 73473045 118473045 5 - by peak with adj size 1549910 rat Bw54 Body weight QTL 54 1 0.05 37356 D1Rat225 35457 D1Rat90 body mass (VT:0001259) body weight (CMO:0000012) abnormal fat pad morphology;increased body weight obesity 1358859 15883013 3360 Pnlip additive Bw115 (maps to same region);Niddm24 (maps to same region) 1 283061367 289137268 1 - by flanking markers 1 261180160 267111153 1 - by flanking markers 1358995 F344.OLETF-(D1Rat166-D1Rat90)/Tj 1 236795785 281795785 4 - by one flank marker only 1 214647894 259647894 4 - by one flank marker only 1549911 rat Stresp9 Stress response QTL 9 1 6.13 0.0035 1.7 39116 D1Rat145 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1549912 rat Bp268 Blood pressure QTL 268 10 41962 D12Arb6 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure;increased systemic arterial systolic blood pressure hypertension 1358144;1625680 15809361;17460389 12 20650729 54450796 5 - by peak with adj size 12 14356765 46782294 5 - by peak with adj size 69369 631576 SS LEW/CrlCrlj 12 18752593 52716770 5 - by peak with adj size 12 13182736 46669029 5 - by peak with adj size 1549913 rat Stresp13 Stress response QTL 13 2 4.56 0.0011 1.8 39914 D2Rat188 stress-related behavior trait (VT:0010451) post-insult time to onset of defensive burying response (CMO:0001962) abnormal coping response;decreased coping response;increased anxiety-related response anxiety disorder 1358767 15685431 Despr1 (maps to same region) 1 122414658 167414658 5 - by peak with adj size 2 1 23400664 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 1554317 rat Bmd4 Bone mineral density QTL 4 10 9.4 1.0E-4 35386 D10Rat8 36249 D10Rat45 36886 D10Rat32 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896;2316850 16180139;19841953 2161;2711;2920;3926;620677;620826;621140;621625;708568;1307023;1307496;1307522;1359691 Asgr2;Slc2a4;Irf1;Ube2i;Ltc4s;Akap1;G3bp1;Aurkb;Rabep1;Rhot1;Plxdc1;Rnps1;Rflnb 10 20046466 102560630 1 - by flanking markers 10 20233281 104013574 1 - by flanking markers 60994 60999 F344 LEW 10 20170031 102897474 1 - by flanking markers 10 19816042 99406971 1 - by flanking markers 1554318 rat Bmd5 Bone mineral density QTL 5 19 12.1 1.0E-4 35547 D19Rat25 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896 16180139 19 20855340 65855340 5 - by peak with adj size 19 8121935 53121935 5 - by peak with adj size 60994 60999 F344 LEW 1554319 rat Bmd2 Bone mineral density QTL 2 2 13.4 1.0E-4 35613 D2Rat59 38362 D2Rat161 38584 D2Rat91 lumbar vertebra area (VT:0010570) lumbar vertebra cross-sectional area (CMO:0001689) increased bone mineral density osteoporosis 1553896 16180139 2 138120342 247933461 1 - by flanking markers 2 118264840 221131552 1 - by flanking markers 60994 60999 F344 LEW 2 118446793 228582621 1 - by flanking markers 2 114837675 212549332 1 - by flanking markers 1554320 rat Bmd1 Bone mineral density QTL 1 1 12.2 1.0E-4 41498 D1Rat266 41058 D1Rat245 38782 D1Rat136 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896;2293187 16180139;17907919 Bmd10 (interacts with);Bmd15 (interacts with) 1 249747 89565657 2 - by one flank and peak markers 1 390736 74903688 2 - by one flank and peak markers 60994 60999 F344 LEW 1 254393 86904217 2 - by one flank and peak markers 1 509108 86060548 2 - by one flank and peak markers 1554321 rat Bmd3 Bone mineral density QTL 3 8 7.9 1.0E-4 36934 D8Rat10 37580 D8Rat99 35018 D8Rat15 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) increased bone mineral density osteoporosis 1553896 16180139 8 61081077 117431943 1 - by flanking markers 8 43561064 129041809 2 - by one flank and peak markers 60994 60999 F344 LEW 8 44458129 118087517 1 - by flanking markers 8 40952565 123900184 2 - by one flank and peak markers 1556747 rat Calcic1 Intracellular calcium level QTL 1 12 3.6 19.8 34729 D12Mgh5 34373 D12Mgh6 2174 Atp2a2 platelet calcium amount (VT:0010500) platelet intracellular calcium level (CMO:0000922) hypertension 1547855 15882549 2174 Atp2a2 12 33647399 49270175 2 - by one flank and peak markers 12 29130180 42387195 1 - by flanking markers 631604 1556748 SHR/Snk F344/Snk 12 31723565 47433663 2 - by one flank and peak markers 12 28064433 40130419 2 - by one flank and peak markers 1558640 rat Prcs2 Prostate cancer susceptibility QTL 2 20 3.3 37594 D20Rat41 35657 D20Rat5 34872 D20Rat3 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hyperplasia Prostatic Neoplasms 1358944 15805257 69328 Cdkn1a dominant 20 6118659 21025734 1 - by flanking markers 20 4740609 18411969 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 20 4039113 18872273 1 - by flanking markers 20 4606607 17617956 1 - by flanking markers 1558641 rat Cm47 Cardiac mass QTL 47 6 2.9 0.001 34126 D6Mgh4 33977 D6Mit4 34306 D6Mgh5 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 6 70194178 117391806 1 - by flanking markers 6 59946874 108503674 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 6 60606431 108154445 1 - by flanking markers 6 57730540 104085867 1 - by flanking markers 1558642 rat Prcr2 Prostate cancer resistance QTL 2 1 4.3 38028 D1Rat121 38134 D15Rat45 37974 D1Rat211 prostate integrity trait (VT:0010571) area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hypoplasia Prostatic Neoplasms 1358944 15805257 1 23292314 45739646 1 - by flanking markers 1 21288064 38490502 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 1 21812623 44409802 1 - by flanking markers 1 20763158 44095856 1 - by flanking markers 1558643 rat Cm44 Cardiac mass QTL 44 10 4.8 3.68E-5 34445 D10Mgh6 34128 D10Mgh1 3177 Ngfr heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw57 (maps to same region) 10 63366082 103048942 2 - by one flank and peak markers 10 67677924 100865886 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 64648175 102149713 2 - by one flank and peak markers 10 61345276 99703528 2 - by one flank and peak markers 1558644 rat Cm45 Cardiac mass QTL 45 13 3.6 0.002 11375 D13Arb8 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 13 34129640 79129640 5 - by peak with adj size 13 25198204 70198204 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 13 29076934 74076934 5 - by peak with adj size 13 23692969 68692969 5 - by peak with adj size 1558645 rat Bw55 Body weight QTL 55 1 3.2 0.004 621323 Phox2a body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 Bw59 (maps to same region) 1 150585707 195585707 5 - by peak with adj size 1 136792830 181792830 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 1 144395993 189395993 5 - by peak with adj size 1 133680936 178680936 5 - by peak with adj size 1558646 rat Swd5 Spike wave discharge measurement QTL 5 8 3.45 3.6E-4 12.0 44394 D8Got49 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge frequency (CMO:0001742) absence seizures childhood absence epilepsy 1553898 15030491 8 17667379 62667379 5 - by peak with adj size 8 16442230 61442230 5 - by peak with adj size 1354669 1554304 BN/OrlIcoCrlf GAERS/Mave 8 17666555 62666555 5 - by peak with adj size 8 14906751 59906751 5 - by peak with adj size 1558647 rat Cm46 Cardiac mass QTL 46 3 5.4 5.5E-6 33862 D3Mit9 34347 D3Mgh16 34198 D3Mgh8 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw56 (maps to same region);Cm43 (maps to same region);Cm48 (maps to same region) 3 11361817 39535971 1 - by flanking markers 3 6373454 26674018 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000866 34394121 1 - by flanking markers 3 10778823 30356773 1 - by flanking markers 1558648 rat Smcn1 Smooth muscle cell number QTL 1 2 0.039 3407 Prlr 40466 D2Rat303 blood vessel smooth muscle cell quantity (VT:0010525) aorta smooth muscle cell count per unit vessel length (CMO:0001646) vascular smooth muscle hyperplasia aortic disease 1357419 15741507 2071 Agtr1b 2 84360850 155130826 1 - by flanking markers 2 59507966 131522430 1 - by flanking markers 1357978 SS.MNS-(D2Mit6-D2Rat303)/Ayd 2 60131410 135646395 1 - by flanking markers 2 59134147 127460910 1 - by flanking markers 1558649 rat Bw58 Body weight QTL 58 18 3.4 5.0E-4 34290 D18Mgh4 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 18 56512589 87229863 5 - by peak with adj size 18 57085070 87265094 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 18 57448678 88201929 5 - by peak with adj size 1558650 rat Cm48 Cardiac mass QTL 48 3 4.0 1.0E-4 33862 D3Mit9 34347 D3Mgh16 34347 D3Mgh16 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw56 (maps to same region);Cm43 (maps to same region);Cm46 (maps to same region) 3 11361817 39535971 1 - by flanking markers 3 6373454 26674018 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 3 6000866 34394121 1 - by flanking markers 3 10778823 30356773 1 - by flanking markers 1558651 rat Swd3 Spike wave discharge measurement QTL 3 4 4.62 2.4E-5 13.7 43803 D4Got39 60456 D4Got74 10144 D4Mgh16 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge frequency (CMO:0001742) absence seizures childhood absence epilepsy 1553898 15030491 4 56868238 157791280 1 - by flanking markers 4 56704868 91916048 1 - by flanking markers 1354669 1554304 BN/OrlIcoCrlf GAERS/Mave 4 57101077 92990863 1 - by flanking markers 4 58432133 92991462 1 - by flanking markers 1558652 rat Bw57 Body weight QTL 57 10 4.2 8.0E-4 2493 Ace 34128 D10Mgh1 67318 D10Arb12 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311;2312611 16097372;19697080 Bw87 (maps to same region);Cm44 (maps to same region) 10 92325331 93965127 2 - by one flank and peak markers 10 93730129 95381455 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 94170766 112626471 4 - by one flank marker only 10 89327017 90930437 2 - by one flank and peak markers 1558653 rat Prcr1 Prostate cancer resistance QTL 1 2 5.0 20.3 36093 D2Rat26 36213 D2Rat40 38362 D2Rat161 prostate integrity trait (VT:0010571) area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hypoplasia Prostatic Neoplasms 1358944 15805257 3098 Mme dominant 2 113748813 189197988 1 - by flanking markers 2 73374972 163154358 2 - by one flank and peak markers 737892 1547866 ACI/SegHsd F344/Jcl 2 93995316 169852800 1 - by flanking markers 2 72532993 157142209 2 - by one flank and peak markers 1558654 rat Bw56 Body weight QTL 56 3 4.5 1.71E-5 34347 D3Mgh16 33862 D3Mit9 34347 D3Mgh16 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 Cm43 (maps to same region);Cm46 (maps to same region);Cm48 (maps to same region) 3 11361699 39536215 1 - by flanking markers 3 6373335 26674263 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000748 34394365 1 - by flanking markers 3 10778704 30357018 1 - by flanking markers 1558655 rat Swd4 Spike wave discharge measurement QTL 4 7 3.68 2.0E-4 12.0 34511 D7Mgh5 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge severity grade (CMO:0001988) absence seizures childhood absence epilepsy 1553898 15030491 7 96625708 141625708 5 - by peak with adj size 7 93320292 138320292 5 - by peak with adj size 1354669 1554304 BN/OrlIcoCrlf GAERS/Mave 7 96630946 141630946 5 - by peak with adj size 7 86983365 131983365 5 - by peak with adj size 1558656 rat Prcs1 Prostate cancer susceptibility QTL 1 19 5.0 17.6 38032 D19Rat101 39212 D19Rat46 40998 D19Rat75 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) abnormal prostate gland morphology;abnormal prostate gland physiology;increased prostate gland tumor incidence;prostate gland hyperplasia Prostatic Neoplasms 1358944 15805257 19 27017884 49665957 1 - by flanking markers 19 16245310 36472155 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 19 15939528 38798459 1 - by flanking markers 19 15114598 34521833 1 - by flanking markers 1558657 rat Cm43 Cardiac mass QTL 43 3 6.6 2.93E-8 33862 D3Mit9 34347 D3Mgh16 34198 D3Mgh8 heart mass (VT:0007028) heart wet weight (CMO:0000069) cardiac hypertrophy;increased heart weight Cardiomegaly 1554311 16097372 Bw56 (maps to same region);Cm46 (maps to same region);Cm48 (maps to same region) 3 11361817 39535971 1 - by flanking markers 3 6373454 26674018 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000866 34394121 1 - by flanking markers 3 10778823 30356773 1 - by flanking markers 1558658 rat Bw59 Body weight QTL 59 1 3.5 3.0E-4 36580 D1Rat112 body mass (VT:0001259) body weight (CMO:0000012) abnormal body weight;increased body weight 1554311 16097372 Bw55 (maps to same region) 1 203609197 248609197 5 - by peak with adj size 1 184074275 229074275 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 1 196738546 241738546 5 - by peak with adj size 1 178784622 223784622 5 - by peak with adj size 1558659 rat Tescar1 Testicular tumor resistance QTL 1 11 3.9 39504 D11Rat88 39084 D11Rat93 testis integrity trait (VT:0010572) percentage of study population developing testis tumors during a period of time (CMO:0001261) increased testis tumor incidence Testicular Neoplasms 1358944 15805257 11 324296 72433053 1 - by flanking markers 11 597138 67931151 1 - by flanking markers 737892 1547866 ACI/SegHsd F344/Jcl 11 325031 69342559 1 - by flanking markers 11 1041931 66113562 1 - by flanking markers 1559055 rat Bp278 Blood pressure QTL 278 17 0.04 38706 D17Rat84 12903975 D17Chm71 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1547847;1601352;1599557 15632271;17420333;17143582 17 23473207 68473207 4 - by one flank marker only 17 29603712 72799224 1 - by flanking markers 1559033 1559035 SS.LEW-(D17Rat65-Prl)/Ayd SS.LEW-(D17Chm14-D17Rat181)/Ayd 17 21490950 66490950 4 - by one flank marker only 17 23653184 68653184 4 - by one flank marker only 1559282 rat Emca5 Estrogen-induced mammary cancer QTL 5 3 3.9 41780 D3Rat227 40440 D3Rat210 37980 D3Rat114 mammary gland integrity trait (VT:0010552) percentage of study population developing mammary tumors during a period of time (CMO:0000948) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 dominant 3 50522686 183740530 2 - by one flank and peak markers 3 41054012 171063335 2 - by one flank and peak markers 10008 737892 BN/SsNHsd ACI/SegHsd 3 45406058 177699992 2 - by one flank and peak markers 3 43827364 169034231 2 - by one flank and peak markers 1559283 rat Emca4 Estrogen-induced mammary cancer QTL 4 7 3.7 34999 D7Rat44 36661 D7Rat15 35841 D7Rat19 mammary gland integrity trait (VT:0010552) percentage of study population developing mammary tumors during a period of time (CMO:0000948) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 dominant Emca8 (interacts with);Ept7 (maps to same region) 7 69590305 110975995 1 - by flanking markers 7 66201980 107428439 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 7 69399586 111043530 1 - by flanking markers 7 62004452 101773158 1 - by flanking markers 1576302 rat Schws4 Schwannoma susceptibility QTL 4 6 0.0078 42328 D6Rat218 5503130 NGB 33662 D6Mit1 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300;11556249 16003739;21427360 727780 Gpx2 6 96954540 120415502 2 - by one flank and peak markers 6 86446712 111234448 2 - by one flank and peak markers 1566454 1566456 BDIV/Zte BDIX/Zte 6 87418448 111129520 2 - by one flank and peak markers 6 83190345 106747639 2 - by one flank and peak markers 1576303 rat Ept7 Estrogen-induced pituitary tumorigenesis QTL 7 7 3.7 34999 D7Rat44 36661 D7Rat15 35841 D7Rat19 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1566582;1642526;8662361;1642522 17876666;24448715;16885383 3130;3904;621120 Myc;Trhr;Cdk4 recessive Emca4 (maps to same region) 7 69590305 110975995 1 - by flanking markers 7 66201980 107428439 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 7 69399586 111043530 1 - by flanking markers 7 62004452 101773158 1 - by flanking markers 1576304 rat Schws7 Schwannoma susceptibility QTL 7 10 0.0115 44670 D10Got1 36249 D10Rat45 34254 D10Mgh12 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300;11554205 16003739;26530423 10 3662335 20046466 1 - by flanking markers 10 4697541 20233281 1 - by flanking markers 1566454 1566456 BDIV/Zte BDIX/Zte 10 4835638 20170031 1 - by flanking markers 11554329 BDIX.BDIV-D10Got1-D10Rat45/Zte 10 4765527 19816042 1 - by flanking markers 1576305 rat Emca6 Estrogen-induced mammary cancer QTL 6 4 5.8 35625 D4Rat14 40322 D4Rat202 38262 D4Rat103 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 recessive Ept5 (maps to same region) 4 44024230 222493466 1 - by flanking markers 4 41729583 159115617 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 4 43414605 155469929 1 - by flanking markers 4 44463720 155883716 1 - by flanking markers 1576306 rat Schws3 Schwannoma susceptibility QTL 3 3 0.001 33810 D3Mit2 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300 16003739 3 132251620 177251620 5 - by peak with adj size 3 120714678 165714678 5 - by peak with adj size 1566454 1566456 BDIV/Zte BDIX/Zte 3 125848628 170848628 5 - by peak with adj size 3 118839124 163839124 5 - by peak with adj size 1576307 rat Cia28 Collagen induced arthritis QTL 28 10 35256 D10Rat11 61275 D10Arb22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) Experimental Arthritis 1359065;1642451;2307198 15944295;17673937;18540828 10 99184058 107484761 1 - by flanking markers 10 100633512 110718848 4 - by one flank marker only 1299877 DA.F344-(D10Rat204-D10Arb22)/Arb 10 99492217 107857673 1 - by flanking markers 10 96120911 104060283 1 - by flanking markers 1576308 rat Schws1 Schwannoma susceptibility QTL 1 10 0.0041 34053 D10Mit3 34202 D10Mgh16 10662 D10Wox23 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300;11554205 16003739;26530423 10 41091453 105757970 1 - by flanking markers 10 41339689 107260629 1 - by flanking markers 1566454 1566456 BDIV/Zte BDIX/Zte 10 41260363 106105607 1 - by flanking markers 11554327 BDIX.BDIV-D10Mit3-D10Mgh16/Zte 10 40035094 102359817 1 - by flanking markers 1576309 rat Emca7 Estrogen-induced mammary cancer QTL 7 6 4.0 39190 D6Rat68 38390 D6Rat81 35140 D6Rat22 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885 16885383;18057545 dominant Emca2 (interacts with) 6 2516723 120995129 1 - by flanking markers 6 2802670 111967837 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 6 2537030 111715717 1 - by flanking markers 6 15107216 107351382 1 - by flanking markers 1576310 rat Schws2 Schwannoma susceptibility QTL 2 1 0.029 33646 D1Mit4 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) increased incidence of induced tumors neurilemmoma 1559300 16003739 1566454 1566456 BDIV/Zte BDIX/Zte 1576311 rat Pia26 Pristane induced arthritis QTL 26 10 33565 D10Mit9 35513 D10Rat24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint swelling Experimental Arthritis;Experimental Arthritis 1359065;2300006;2302383;1358860;2307198 15944295;18706093;18668563;15641042;18540828 3612;3965;1307740;1308885;1309749 Ncor1;Trpv2;Natd1;Trim41;Trim16 10 31740635 78195122 1 - by flanking markers 10 31931622 79229233 1 - by flanking markers 1358990 DA.F344-(D10Mit9-D10Rat24)/Nsi 10 31919397 78343192 1 - by flanking markers 10 31224026 75632053 1 - by flanking markers 1576312 rat Emca8 Estrogen-induced mammary cancer QTL 8 5 4.1 39722 D5Rat134 35651 D5Rat37 37950 D5Rat95 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1559271;1642522;2291885;7364727 16885383;18057545;23151807 dominant Emca1 (maps to same region);Emca4 (interacts with) 5 55977668 151220567 1 - by flanking markers 5 52434178 148460381 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 5 51418671 147487820 1 - by flanking markers 5 50328551 141643988 1 - by flanking markers 1576313 rat Pia25 Pristane induced arthritis QTL 25 10 35256 D10Rat11 61275 D10Arb22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) Experimental Arthritis 1359065 15944295 10 99184058 107484761 1 - by flanking markers 10 100633512 110718848 4 - by one flank marker only 1299877 DA.F344-(D10Rat204-D10Arb22)/Arb 10 99492217 107857673 1 - by flanking markers 10 96120911 104060283 1 - by flanking markers 1576314 rat Eutr1 Estrogen induced uterine response QTL 1 5 38744 D5Rat116 36811 D5Rat16 36558 D5Rat19 uterus integrity trait (VT:0010575) pyometritis severity score (CMO:0002009) reproductive system inflammation Inflammation;bacterial infectious disease 1559292 16284801 incomplete_dominance 5 1521341 82842091 1 - by flanking markers 5 1220773 79863911 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 5 1525098 78720537 1 - by flanking markers 5 2138965 166875058 2 - by one flank and peak markers 1576315 rat Schws6 Schwannoma susceptibility QTL 6 15 0.0069 34357 D15Mgh4 nervous system integrity trait (VT:0010566) post-insult time of death (CMO:0002005) increased incidence of induced tumors neurilemmoma 1559300 16003739 15 64956643 109956643 5 - by peak with adj size 15 60849424 105849424 5 - by peak with adj size 1566454 1566456 BDIV/Zte BDIX/Zte 15 61447766 106447766 5 - by peak with adj size 15 53806152 98806152 5 - by peak with adj size 1576316 rat Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 4 3.8 38262 D4Rat103 39414 D4Rat204 34174 D4Mgh7 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 1566582;1642526;1642522 17876666;16885383 2688;3556;3849;3903;69062;621083;632283 Ghrhr;Ret;Tgfa;Trh;Cdkn1b;Ccnd2;Ghrl dominant Emca6 (maps to same region) 4 149135946 243120755 1 - by flanking markers 4 82700691 182307104 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 4 84475257 178931073 1 - by flanking markers 4 83428419 177635233 1 - by flanking markers 1576317 rat Eutr2 Estrogen induced uterine response QTL 2 5 0.01 36113 D5Rat1 34041 D5Mit5 uterus integrity trait (VT:0010575) pyometritis severity score (CMO:0002009) reproductive system inflammation Inflammation;bacterial infectious disease 1559291 16284802 5 39876314 112058005 1 - by flanking markers 5 35911094 109163425 1 - by flanking markers 1331830 F344.BN-(D5Rat1-D5Mit5)/Dlw 5 35225432 108092802 1 - by flanking markers 5 34730116 104251008 1 - by flanking markers 1576318 rat Schws5 Schwannoma susceptibility QTL 5 13 0.0351 42383 D13Rat191 nervous system integrity trait (VT:0010566) post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019) increased incidence of induced tumors neurilemmoma 1559300 16003739 13 72405088 117405088 5 - by peak with adj size 13 65464406 110464406 5 - by peak with adj size 1566454 1566456 BDIV/Zte BDIX/Zte 1576319 rat Cia29 Collagen induced arthritis QTL 29 10 36496 D10Rat37 10641 D10Wox22 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) Experimental Arthritis 1359065 15944295 10 34910943 94240491 1 - by flanking markers 10 35131252 95695218 1 - by flanking markers 1359004 DA.F344-(D10Mit9-D10Rat11)/Nsi 10 35139424 80139424 4 - by one flank marker only 10 33973921 78973921 4 - by one flank marker only 1578646 rat Bmd18 Bone mineral density QTL 18 15 5.2 41564 D15Rat80 40516 D15Rat106 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307 16461031 15 30309351 109944957 1 - by flanking markers 15 25506124 106177917 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 15 26381041 106550657 1 - by flanking markers 15 22806240 98288169 1 - by flanking markers 1578647 rat Bmd17 Bone mineral density QTL 17 15 4.0 41564 D15Rat80 40516 D15Rat106 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 15 30309351 109944957 1 - by flanking markers 15 25506124 106177917 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 15 26381041 106550657 1 - by flanking markers 15 22806240 98288169 1 - by flanking markers 1578648 rat Bss11 Bone structure and strength QTL 11 2 4.7 38362 D2Rat161 39878 D2Rat242 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 2 138120195 247064731 1 - by flanking markers 2 118264490 220244597 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 2 118446646 227707979 1 - by flanking markers 2 114837527 211674221 1 - by flanking markers 1578649 rat Bmd8 Bone mineral density QTL 8 1 4.9 35891 D1Rat19 41498 D1Rat266 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307 16461031 1 50173150 95173150 4 - by one flank marker only 1 43872710 88872710 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 1 49578577 94578577 4 - by one flank marker only 1 49393172 94393172 4 - by one flank marker only 1578650 rat Bmd6 Bone mineral density QTL 6 1 12.2 41058 D1Rat245 38782 D1Rat136 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 1 249747 44907799 1 - by flanking markers 1 390736 37647484 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 254393 43579402 1 - by flanking markers 1 509108 43284926 1 - by flanking markers 1578651 rat Bmd7 Bone mineral density QTL 7 1 14.2 41058 D1Rat245 38782 D1Rat136 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307 16461031 1 249747 44907799 1 - by flanking markers 1 390736 37647484 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 254393 43579402 1 - by flanking markers 1 509108 43284926 1 - by flanking markers 1578652 rat Bmd15 Bone mineral density QTL 15 7 5.2 37262 D7Rat64 38198 D7Rat69 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307;2293187 16461031;17907919 Bmd1 (interacts with) 7 12857572 67991627 1 - by flanking markers 7 11379354 64612198 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 7 12687850 67801690 1 - by flanking markers 7 9866467 60460686 1 - by flanking markers 1578653 rat Vnigr3 Vascular neointimal growth QTL 3 3 3.1 11278 D3Arb12 artery morphology trait (VT:0002191) artery neointimal hyperplastic lesion area (CMO:0001414) artery occlusion;vascular smooth muscle hyperplasia Hyperplasia 1578306;2316923 16434542;20026763 3 144554463 183740530 5 - by peak with adj size 3 132947812 171063335 5 - by peak with adj size 10008 724574 BN/SsNHsd SHR/NHsd 3 138374177 177699992 5 - by peak with adj size 3 130656562 169034231 5 - by peak with adj size 1578654 rat Bss10 Bone structure and strength QTL 10 1 4.0 35891 D1Rat19 37092 D1Rat52 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 1 50173150 176864669 1 - by flanking markers 1 43872710 162735928 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 49578577 169852184 1 - by flanking markers 1 49393172 159356837 1 - by flanking markers 1578655 rat Bmd11 Bone mineral density QTL 11 4 11.0 41458 D4Rat153 41616 D4Rat193 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307;2300256 16461031;18728226 4 89422120 134422120 4 - by one flank marker only 4 93201451 138201451 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 24631874 69631874 4 - by one flank marker only 4 90850165 135850165 4 - by one flank marker only 1578656 rat Vnigr2 Vascular neointimal growth QTL 2 3 4.2 11278 D3Arb12 artery morphology trait (VT:0002191) lesioned artery residual lumen area (CMO:0001417) Hyperplasia 1578306 16434542 3 144554463 183740530 5 - by peak with adj size 3 132947812 171063335 5 - by peak with adj size 10008 724574 BN/SsNHsd SHR/NHsd 3 138374177 177699992 5 - by peak with adj size 3 130656562 169034231 5 - by peak with adj size 1578657 rat Bss12 Bone structure and strength QTL 12 4 8.9 37378 D4Rat123 39916 D4Rat175 femur morphology trait (VT:0000559) femoral neck cross-sectional area (CMO:0001697) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 120851785 165851785 4 - by one flank marker only 4 61483655 106483655 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 56092756 101092756 4 - by one flank marker only 4 60220938 105220938 4 - by one flank marker only 1578658 rat Bss13 Bone structure and strength QTL 13 4 8.0 37378 D4Rat123 39916 D4Rat175 femur strength trait (VT:0010010) femoral neck polar moment of inertia (CMO:0001670) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 120851785 165851785 4 - by one flank marker only 4 61483655 106483655 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 56092756 101092756 4 - by one flank marker only 4 60220938 105220938 4 - by one flank marker only 1578659 rat Tspe1 Trichinella spiralis expulsion QTL 1 9 4.8 11.0 34815 D9Rat16 35843 D9Rat13 35172 D9Rat19 parasite quantity (VT:0010441) logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024) decreased susceptibility to parasitic infection Nematode Infections;Parasitic Intestinal Diseases 1578305 16465509 2299;620123 Cd28;Icos 9 66570118 71564273 1 - by flanking markers 9 58516719 62957638 1 - by flanking markers 61111 1302627 DA/Slc F344/NSlc 9 66757444 71010122 1 - by flanking markers 9 61381434 65691299 1 - by flanking markers 1578660 rat Bss19 Bone structure and strength QTL 19 15 4.3 41564 D15Rat80 40516 D15Rat106 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307 16461031 15 30309351 109944957 1 - by flanking markers 15 25506124 106177917 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 15 26381041 106550657 1 - by flanking markers 15 22806240 98288169 1 - by flanking markers 1578661 rat Bss20 Bone structure and strength QTL 20 18 3.7 37578 D18Rat65 39278 D18Rat44 femur morphology trait (VT:0000559) femoral neck cross-sectional area (CMO:0001697) abnormal bone structure osteoporosis 1578307 16461031 18 15466312 86114102 1 - by flanking markers 18 12245097 86863412 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 18 15695872 87080053 1 - by flanking markers 18 11791518 83218561 1 - by flanking markers 1578662 rat Bss15 Bone structure and strength QTL 15 4 19.6 37378 D4Rat123 35070 D4Rat57 femur width (VT:1000666) femoral neck width (CMO:0001695) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 151627684 196627684 4 - by one flank marker only 4 89539438 134539438 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 87136446 132136446 4 - by one flank marker only 4 87327165 132327165 4 - by one flank marker only 1578663 rat Bss18 Bone structure and strength QTL 18 10 3.6 38542 D10Rat132 35254 D10Rat2 femur width (VT:1000666) femoral neck width (CMO:0001695) abnormal bone structure osteoporosis 1578307 16461031 10 99844504 110568670 1 - by flanking markers 10 101222719 110718848 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 10 100155035 110992275 1 - by flanking markers 10 96703043 107057807 1 - by flanking markers 1578664 rat Bmd9 Bone mineral QTL density 9 2 5.0 36912 D2Rat1 38950 D2Rat173 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 2 9324722 67988414 1 - by flanking markers 2 9670332 49013509 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 2 9444679 49615930 1 - by flanking markers 2 11852062 49003364 1 - by flanking markers 1578665 rat Bss16 Bone structure and strength QTL 16 6 4.4 38006 D6Rat69 35140 D6Rat22 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307 16461031 6 6120187 85538444 1 - by flanking markers 6 6265856 75462111 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 6 6161722 76002731 1 - by flanking markers 6 11735669 72593685 1 - by flanking markers 1578666 rat Vnigr1 Vascular neointimal growth QTL 1 3 4.6 41210 D3Rat145 36745 D3Rat1 11278 D3Arb12 artery morphology trait (VT:0002191) artery lumen area (CMO:0001409) Hyperplasia 1578306 16434542 3 162615336 180128021 1 - by flanking markers 3 151160532 170016653 1 - by flanking markers 10008 724574 BN/SsNHsd SHR/NHsd 3 156381661 176418101 1 - by flanking markers 3 149040888 168026850 1 - by flanking markers 1578667 rat Bss21 Bone structure and strength QTL 21 18 3.5 37578 D18Rat65 39278 D18Rat44 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 18 15466312 86114102 1 - by flanking markers 18 12245097 86863412 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 18 15695872 87080053 1 - by flanking markers 18 11791518 83218561 1 - by flanking markers 1578668 rat Bmd14 Bone mineral density QTL 14 6 3.8 38006 D6Rat69 35140 D6Rat22 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 1578307 16461031 6 6120187 85538444 1 - by flanking markers 6 6265856 75462111 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 6 6161722 76002731 1 - by flanking markers 6 11735669 72593685 1 - by flanking markers 1578669 rat Bss9 Bone structure and strength QTL 9 1 6.3 41058 D1Rat245 38782 D1Rat136 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307 16461031 1 249747 44907799 1 - by flanking markers 1 390736 37647484 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 1 254393 43579402 1 - by flanking markers 1 509108 43284926 1 - by flanking markers 1578670 rat Bss14 Bone structure and strength QTL 14 4 16.4 37378 D4Rat123 35070 D4Rat57 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) abnormal bone structure osteoporosis 1578307;2300256 16461031;18728226 4 151627684 196627684 4 - by one flank marker only 4 89539438 134539438 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 87136446 132136446 4 - by one flank marker only 4 87327165 132327165 4 - by one flank marker only 1578671 rat Bmd10 Bone mineral density QTL 10 2 5.4 36912 D2Rat1 35915 D2Rat61 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307;2293187 16461031;17907919 Bmd1 (interacts with) 2 9324722 88595515 1 - by flanking markers 2 9670332 227150249 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 2 9444679 68866454 1 - by flanking markers 1578672 rat Bmd16 Bone mineral density QTL 16 10 6.2 38542 D10Rat132 35254 D10Rat2 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307 16461031 10 99844504 110568670 1 - by flanking markers 10 101222719 110718848 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 10 100155035 110992275 1 - by flanking markers 10 96703043 107057807 1 - by flanking markers 1578673 rat Bmd13 Bone mineral density QTL 13 5 4.9 41560 D5Rat153 39600 D5Rat154 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density osteoporosis 1578307 16461031 5 111095780 156095780 4 - by one flank marker only 5 108589975 153589975 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 5 107119214 152119214 4 - by one flank marker only 5 103689353 148689353 4 - by one flank marker only 1578674 rat Bmd12 Bone mineral density QTL 12 4 3.8 41458 D4Rat153 37340 D4Rat84 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 1578307 16461031 4 201313537 246313537 4 - by one flank marker only 4 140398530 185398530 4 - by one flank marker only 61109 1298093 F344/NHsd LEW/NHsd 4 137171018 182171018 4 - by one flank marker only 4 135699135 180699135 4 - by one flank marker only 1578675 rat Bss17 Bone structure and strength QTL 17 9 3.8 37468 D9Rat162 35623 D9Rat41 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) abnormal bone structure osteoporosis 1578307 16461031 9 1861508 14478042 1 - by flanking markers 9 4796492 8991332 1 - by flanking markers 61109 1298093 F344/NHsd LEW/NHsd 9 1907834 15555026 1 - by flanking markers 9 3368652 13533896 1 - by flanking markers 1578754 rat Stresp16 Stress response QTL 16 3 4.0 0.001 33927 D3Mit3 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 recessive 3 125887975 170887975 5 - by peak with adj size 3 113902006 158902006 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 3 119471263 164471263 5 - by peak with adj size 3 112681431 157681431 5 - by peak with adj size 1578755 rat Pur5 Proteinuria QTL 5 8 3.3 1.0E-4 33559 D8Mit5 41310 D8Rat130 34763 D8Rat62 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520;2314528 16534143;19176703 8 33603024 100888674 1 - by flanking markers 8 32203394 98986263 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 8 33558660 109028082 2 - by one flank and peak markers 8 30848154 101699754 2 - by one flank and peak markers 1578756 rat Iddm22 Insulin dependent diabetes mellitus QTL 22 1 2.7 38202 D1Rat229 33931 D1Mit10 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) abnormal pancreatic islet morphology;hyperglycemia;increased susceptibility to autoimmune disorder hyperglycemia;type 1 diabetes mellitus;type 1 diabetes mellitus 1547853 16075370 3732 Sod2 1 13788254 58788254 4 - by one flank marker only 1578710 1578713 LEW.1AR1-iddm/Ztm BN/Ztm 1 50522714 57861469 1 - by flanking markers 1 11835181 56835181 4 - by one flank marker only 1578757 rat Pur6 Proteinuria QTL 6 9 3.3 0.005 62516 D9Uia4 66431 D9Mco6 61287 D9Uia6 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 9 67265475 99638395 2 - by one flank and peak markers 9 59247346 105580061 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 9 67451664 99920892 2 - by one flank and peak markers 9 62072275 96470995 2 - by one flank and peak markers 1578758 rat Tcas9 Tongue tumor susceptibility QTL 9 6 3.29 35647 D6Rat55 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 6 1 25028411 5 - by peak with adj size 6 1 25291384 5 - by peak with adj size 60997 61007 DA WF 6 1 25048718 5 - by peak with adj size 6 1 37618905 5 - by peak with adj size 1578759 rat Uae30 Urinary albumin excretion QTL 30 1 3.3 0.003 36703 D1Rat86 37168 D1Rat158 36703 D1Rat86 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 1 167535765 281205119 1 - by flanking markers 1 153578547 259173275 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 1 161321256 273791893 1 - by flanking markers 1 150700247 252085048 1 - by flanking markers 1578760 rat Cm53 Cardiac mass QTL 53 9 3.3 1.0E-4 66431 D9Mco6 61287 D9Uia6 61287 D9Uia6 heart mass (VT:0007028) heart wet weight (CMO:0000069) decreased heart weight Albuminuria;proteinuria 1578520 16534143 9 60951935 105951935 5 - by peak with adj size 9 77171049 105579863 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 9 61186278 106186278 5 - by peak with adj size 9 56771635 101771635 5 - by peak with adj size 1578761 rat Stresp21 Stress response QTL 21 10 3.3 39102 D10Rat71 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) anxiety disorder 1549862 16151695 recessive 10 7355194 52355194 5 - by peak with adj size 10 7041744 52041744 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 10 7521450 52521450 5 - by peak with adj size 10 6375746 51375746 5 - by peak with adj size 1578762 rat Toxo1 Toxoplasma gondii resistance QTL 1 10 37986 D10Rat116 37720 D10Rat80 brain integrity trait (VT:0010579) percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028) decreased susceptibility to parasitic infection toxoplasmosis 1578521 16407112 10 53807244 61030524 1 - by flanking markers 10 54220109 61798393 1 - by flanking markers 631593 631594 LEW/Rj BN/Rj 10 54057616 61300905 1 - by flanking markers 10 52200030 59378278 1 - by flanking markers 1578763 rat Kidm29 Kidney mass QTL 29 1 3.3 1.0E-4 35174 D1Rat66 66610 D1Mco35 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) abnormal kidney morphology Albuminuria;proteinuria 1578520 16534143 1 203383063 290094216 2 - by one flank and peak markers 1 183946692 267910886 2 - by one flank and peak markers 10041 724574 SS/Jr SHR/NHsd 1 196395041 282763074 2 - by one flank and peak markers 1 179567751 260522016 2 - by one flank and peak markers 1578764 rat Stresp19 Stress response QTL 19 19 3.6 0.001 41174 D19Rat71 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 recessive 19 29822065 72914587 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 19 18993982 62275575 5 - by peak with adj size 19 15630201 57337602 5 - by peak with adj size 1578765 rat Klgr1 Kidney lesion grade QTL 1 8 3.3 1.0E-4 41310 D8Rat130 33559 D8Mit5 34763 D8Rat62 kidney morphology trait (VT:0002135) organ lesion measurement (CMO:0000677) Albuminuria;proteinuria 1578520 16534143 8 33603128 100888495 1 - by flanking markers 8 32203499 98986085 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 8 33558660 109028082 2 - by one flank and peak markers 8 30848154 101699754 2 - by one flank and peak markers 1578766 rat Tcas11 Tongue tumor susceptibility QTL 11 5 4.12 22.7 34467 D5Mgh16 11072 D5Mgh2 2324 Cdkn2b tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 1578522 16527513 Tcas8 (maps to same region) 5 21842328 171522628 1 - by flanking markers 5 17517235 168005953 1 - by flanking markers 60997 734761 DA WF/Kga 5 47745646 167946134 2 - by one flank and peak markers 5 46711509 161317411 2 - by one flank and peak markers 1578767 rat Stresp17 Stress response QTL 17 5 4.3 0.01 35076 D5Rat6 blood aldosterone amount (VT:0005346) plasma aldosterone level (CMO:0000551) anxiety disorder 1549862 16151695 dominant 5 33639290 78639290 5 - by peak with adj size 5 30030683 75030683 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 5 29078899 74078899 5 - by peak with adj size 5 27955440 72955440 5 - by peak with adj size 1578768 rat Stresp22 Stress response QTL 22 16 2.8 40320 D16Rat66 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) anxiety disorder 1549862 16151695 additive 16 38671706 83671706 5 - by peak with adj size 16 39026337 84026337 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 16 39000021 84000021 5 - by peak with adj size 16 35288870 80288870 5 - by peak with adj size 1578769 rat Uae31 Urinary albumin excretion QTL 31 8 3.3 0.001 41310 D8Rat130 33559 D8Mit5 34763 D8Rat62 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520;2314528 16534143;19176703 8 33603128 100888495 1 - by flanking markers 8 32203499 98986085 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 8 33558660 109028082 2 - by one flank and peak markers 8 30848154 101699754 2 - by one flank and peak markers 1578770 rat Stresp23 Stress response QTL 23 1 60784 D1Wox29 11359 D1Arb21 kidney sympathetic nerve activity (VT:0004050) stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786) increased heart rate;increased renal sympathetic nerve activity;increased systemic arterial blood pressure anxiety disorder 1578503 16239369 1 131822204 206277202 1 - by flanking markers 1 124614679 187092492 1 - by flanking markers 1302636 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers 1578771 rat Stresp20 Stress response QTL 20 8 3.7 0.05 10302 D8Mgh14 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 recessive 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 1578772 rat Stresp14 Stress response QTL 14 2 5.0 0.001 40478 D2Rat277 38256 D2Rat115 39090 D2Rat180 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) anxiety disorder 1549862 16151695 2071 Agtr1b dominant 2 104097430 151745540 1 - by flanking markers 2 83433833 158985677 2 - by one flank and peak markers 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 2 84424139 132130578 1 - by flanking markers 2 82345893 130923501 1 - by flanking markers 1578773 rat Iddm23 Insulin dependent diabetes mellitus QTL 23 20 2.9 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) abnormal pancreatic islet morphology;hyperglycemia;increased susceptibility to autoimmune disorder hyperglycemia;type 1 diabetes mellitus;type 1 diabetes mellitus 1547853 16075370 1311139 Aire 1578710 1578713 LEW.1AR1-iddm/Ztm BN/Ztm 1578774 rat Tcas8 Tongue tumor susceptibility QTL 8 5 3.47 34377 D5Mgh4 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723;1578522 11429048;16527513 Tcas11 (maps to same region) 60997 61007 DA WF 1578775 rat Iddm21 Insulin dependent diabetes mellitus QTL 21 1 4.13 42536 D1Rat496 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) abnormal pancreatic islet morphology;hyperglycemia;increased susceptibility to autoimmune disorder hyperglycemia;type 1 diabetes mellitus;type 1 diabetes mellitus 1547853 16075370 2915;1308521 Ins1;Nkx2-3 1578710 1578713 LEW.1AR1-iddm/Ztm BN/Ztm 1578776 rat Stresp18 Stress response QTL 18 5 2.9 35076 D5Rat6 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) anxiety disorder 1549862 16151695 recessive 5 33639290 78639290 5 - by peak with adj size 5 30030683 75030683 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 5 29078899 74078899 5 - by peak with adj size 5 27955440 72955440 5 - by peak with adj size 1578777 rat Stresp15 Stress response QTL 15 2 2.0 0.05 40478 D2Rat277 blood aldosterone amount (VT:0005346) plasma aldosterone level (CMO:0000551) anxiety disorder 1549862 16151695 2071 Agtr1b dominant 2 81597542 126597542 5 - by peak with adj size 2 60933945 105933945 5 - by peak with adj size 1354669 1554301 BN/OrlIcoCrlf WKHA/Bord 2 61924251 106924251 5 - by peak with adj size 2 59846005 104846005 5 - by peak with adj size 1578778 rat Pur4 Proteinuria QTL 4 1 3.3 0.003 36703 D1Rat86 37168 D1Rat158 36703 D1Rat86 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 1 167535765 281205119 1 - by flanking markers 1 153578547 259173275 1 - by flanking markers 10041 724574 SS/Jr SHR/NHsd 1 161321256 273791893 1 - by flanking markers 1 150700247 252085048 1 - by flanking markers 1578779 rat Tcas10 Tongue tumor susceptibility QTL 10 10 3.12 11479 D10Mit8 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) increased tongue tumor incidence Tongue Neoplasms 634723 11429048 10 32922090 77922090 5 - by peak with adj size 10 33351756 78351756 5 - by peak with adj size 60997 61007 DA WF 10 33179030 78179030 5 - by peak with adj size 10 31297439 76297439 5 - by peak with adj size 1578780 rat Cm52 Cardiac mass QTL 52 1 3.3 1.0E-4 66589 D1Mco25 37168 D1Rat158 heart mass (VT:0007028) heart wet weight (CMO:0000069) decreased heart weight Albuminuria;proteinuria 1578520 16534143 1 84046907 251024519 2 - by one flank and peak markers 1 81342810 225814178 2 - by one flank and peak markers 10041 724574 SS/Jr SHR/NHsd 1 82788437 239853971 2 - by one flank and peak markers 1 81591954 219808434 2 - by one flank and peak markers 1579915 rat Bp280 Blood pressure QTL 280 10 0.001 37150 D10Rat204 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1559293;1601352;1599557;2292238 16286573;17420333;17143582;18398331 Bp310 (sub_region) 10 93421499 112200500 4 - by one flank marker only 10 94837236 99588446 1 - by flanking markers 1579894 SS.LEW-(D10Rat204-D10Rat9)/Ayd 10 93662786 112626471 4 - by one flank marker only 10 90404397 107211142 4 - by one flank marker only 1579916 rat Bp270 Blood pressure QTL 270 2 0.003 1579094 D2Chm277 3407 Prlr arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased mean systemic arterial blood pressure hypertension 1358142;1599557;7421500 15827238;17143582;23814039 Bp310 (interacts with) 2 76472547 84554681 1 - by flanking markers 2 56722060 59701221 1 - by flanking markers 1549795 1579896 SS.LEW-(D2Rat199-D2Rat143)/Ayd SS.LEW-(D2Rat18-D2Chm277)/Ayd 2 56736401 60325686 1 - by flanking markers 2 56531912 59324719 1 - by flanking markers 1579917 rat Bp282 Blood pressure QTL 282 10 0.001 1579039 D10Chm169 1578994 D10Chm147 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 1559293;1599557;2292238 16286573;17143582;18398331 Bp312 (sub_region) 10 69442184 70215618 1 - by flanking markers 10 70654166 71447820 1 - by flanking markers 1579898 SS.LEW-(D10Chm128-D10Chm121)/Ayd 10 69808793 70581793 1 - by flanking markers 10 67400316 68164786 1 - by flanking markers 1579918 rat Bp279 Blood pressure QTL 279 10 0.01 1578839 D10Chm79 1578891 D10Chm29 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1559293;1599557;7421500;2292238 16286573;17143582;23814039;18398331 Bp256 (interacts with);Bp257 (interacts with);Bp308 (sub_region);Bp309 (sub_region);Bp310 (interacts with);Bp315 (interacts with);Bp346 (interacts with);Bp347 (interacts with);Bp365 (interacts with);Bp38 (interacts with) 10 73626664 75002634 1 - by flanking markers 10 74524802 76098661 1 - by flanking markers 1579901 SS.LEW-(D10Chm224-D10Chm6)/Ayd 10 73727917 75099909 1 - by flanking markers 10 71115217 72606468 1 - by flanking markers 1579919 rat Bp281 Blood pressure QTL 281 10 0.01 44776 D10Got92 1579130 D10Chm154 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1559293;1599557;2292238 16286573;17143582;18398331 Bp311 (sub_region) 10 76919480 97996556 1 - by flanking markers 10 77956239 99440638 1 - by flanking markers 724577 728384 SS.LEW-(D10Rat27-Igfbp4)/Ayd SS.LEW-(D10Rat24-Igfbp4)/Ayd 10 77055741 98282519 1 - by flanking markers 1579914 SS.LEW-(D10Mco30-D10Got92)/Ayd 10 74372084 94965338 1 - by flanking markers 1581497 rat Esta1 Estrogen-induced thymic atrophy QTL 1 10 0.1 36683 D10Rat42 34445 D10Mgh6 34318 D10Mgh10 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 1579780 16688534 incomplete_dominance 10 21575051 63366218 1 - by flanking markers 10 4831560 67678060 2 - by one flank and peak markers 10008 737892 BN/SsNHsd ACI/SegHsd 10 21707766 64648311 1 - by flanking markers 10 21329805 61345413 1 - by flanking markers 1581499 rat Esta2 Estrogen-induced thymic atrophy QTL 2 2 0.08 33727 D2Mit14 39240 D2Rat92 35915 D2Rat61 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 1579780 16688534 2 224018348 262226379 1 - by flanking markers 2 197256223 235940600 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 2 204585642 243689611 1 - by flanking markers 2 189599258 226936289 1 - by flanking markers 1581500 rat Renag1 Renal agenesis QTL 1 14 36053 D14Rat4 39774 D14Rat89 kidney development trait (VT:0000527) percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940) 1580355 16845468 incomplete_dominance 14 9714765 72873313 1 - by flanking markers 14 9428445 73480320 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 14 9756435 72854397 1 - by flanking markers 14 8170668 68298175 1 - by flanking markers 1581502 rat Esta3 Estrogen-induced thymic atrophy QTL 3 2 0.08 36466 D2Rat34 33727 D2Mit14 36466 D2Rat34 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 1579780 16688534 2 161739948 224018437 1 - by flanking markers 2 141755026 197256313 1 - by flanking markers 10008 737892 BN/SsNHsd ACI/SegHsd 2 142053350 204585731 1 - by flanking markers 2 136916935 189599348 1 - by flanking markers 1581503 rat Cm58 Cardiac mass QTL 58 3 2.7 0.05 4.0 41780 D3Rat227 36717 D3Rat17 11261 D3Wox9 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 recessive 3 50522686 133513825 1 - by flanking markers 3 41054012 121619110 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 3 45406058 127023997 1 - by flanking markers 3 43827364 121056321 1 - by flanking markers 1581505 rat Rf54 Renal function QTL 54 5 38338 D5Rat108 36677 D5Rat31 kidney physiology trait (VT:0002136) kidney 20-HETE level (CMO:0001854) renal hypertension 1578407 16396943 2479;68945;628846;631356 Cyp4a2;Cyp4a1;Cyp4a8;Cyp4a3 5 137107818 142265366 1 - by flanking markers 5 134871897 139996194 1 - by flanking markers 1579899 1579902 SS.LEW-(D5Rat130-D5Rat31)/JrMcwi SS.LEW-(D5Rat130-D5Rat108)/JrMcwi 5 133313668 138454239 1 - by flanking markers 5 128033842 133011550 1 - by flanking markers 1581509 rat Cm57 Cardiac mass QTL 57 17 4.5 0.05 5.0 35735 D17Rat49 35827 D17Rat52 35827 D17Rat52 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 67385 Cacnb2 additive 17 86907303 86961249 1 - by flanking markers 17 70094251 97296363 5 - by peak with adj size 631275 631276 WKY/Cfd WKHA/Cfd 17 85183543 85236284 1 - by flanking markers 17 81153923 81208154 1 - by flanking markers 1581510 rat Cm54 Cardiac mass QTL 54 5 3.4 0.05 4.0 35545 D5Rat28 34210 D5Mgh14 40376 D5Rat173 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 recessive 5 129313212 153256206 1 - by flanking markers 5 126963761 150236260 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 5 125455818 149568944 1 - by flanking markers 5 120740824 143608494 1 - by flanking markers 1581512 rat Cm55 Cardiac mass QTL 55 17 2.8 0.05 5.0 34827 D17Rat12 36996 D17Rat31 34120 D17Mgh5 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 additive 17 29605177 63569326 1 - by flanking markers 17 33277173 65478569 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 17 27690959 61794615 1 - by flanking markers 17 27027949 56836890 1 - by flanking markers 1581516 rat Cm56 Cardiac mass QTL 56 12 4.2 0.05 3.0 34439 D12Mgh1 41956 D12Arb13 41956 D12Arb13 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 dominant 12 10334345 15941661 1 - by flanking markers 12 7382953 12240754 1 - by flanking markers 631275 631276 WKY/Cfd WKHA/Cfd 12 1 30749723 5 - by peak with adj size 12 1 29333307 5 - by peak with adj size 1581517 rat Bp284 Blood pressure QTL 284 9 1578935 D9Mco14 3555 Resp18 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1334447;2302803 15655120;18854752 3555 Resp18 Bp333 (maps to same region) 9 82125291 82246695 1 - by flanking markers 9 74436883 74558151 1 - by flanking markers 1579897 1579908 SS.SR-(D9Rat69-D9Mco14)/Mco SS.SR-(D9Mco95-Resp18)/Mco 9 82356030 82477136 1 - by flanking markers 9 76650629 76771824 1 - by flanking markers 1581519 rat Cm59 Cardiac mass QTL 59 15 2.8 0.05 3.0 34162 D15Mgh6 37500 D15Rat41 36149 D15Rat26 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578726 16245027 additive 15 100267081 107428111 2 - by one flank and peak markers 15 96375862 103677388 2 - by one flank and peak markers 631275 631276 WKY/Cfd WKHA/Cfd 15 96777066 104003672 2 - by one flank and peak markers 15 88853470 95840528 2 - by one flank and peak markers 1581544 rat Rf52 Renal function QTL 52 1 0.05 42282 D1Rat475 35457 D1Rat90 10674 D1Mgh12 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) 1578626 16541022 1 260169923 289137268 1 - by flanking markers 1 238613503 267111153 1 - by flanking markers 1579695 1579700 ACI.FHH-(D1Rat298-D1Rat90)/Eur ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur 1 252948438 281795785 1 - by flanking markers 1 232156370 259647894 1 - by flanking markers 1581546 rat Pur13 Proteinuria QTL 13 3 2.93 0.0335 51.8 35356 D3Rat5 35086 D3Rat31 34411 D3Mgh14 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 3 87839442 161185362 1 - by flanking markers 3 76620970 148642985 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 3 81136227 154416635 1 - by flanking markers 3 78196190 146592722 1 - by flanking markers 1581550 rat Pur8 Proteinuria QTL 8 6 10361 D6Wox13 11241 D6Mit3 66623 D6Uia5 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 6 85163291 144273721 1 - by flanking markers 6 75049644 136451997 1 - by flanking markers 1579696 SS.SHR-(D6Wox13-D6Rat84)/Mco 6 75623393 136142742 1 - by flanking markers 6 72227641 130729205 1 - by flanking markers 1581552 rat Pur12 Proteinuria QTL 12 2 5.19 9.0E-4 34.9 37016 D2Rat30 39754 D2Rat223 37456 D2Rat147 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 2 135417671 173567664 1 - by flanking markers 2 116504240 153393151 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 2 115721880 154182196 1 - by flanking markers 2 112103657 148076632 1 - by flanking markers 1581553 rat Pur14 Proteinuria QTL 14 17 5.3 1.0E-4 36.7 37386 D17Rat76 43082 D17Rat142 38992 D17Rat61 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 17 10600735 18672009 1 - by flanking markers 17 13930240 22447143 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 17 8424467 16620067 1 - by flanking markers 17 7979968 16317111 1 - by flanking markers 1581554 rat Pur11 Proteinuria QTL 11 13 37240 D13Rat63 33923 D13Mit1 11231 D13Wox5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level proteinuria 1578520 16534143 13 14282000 87877309 1 - by flanking markers 13 25430276 80482326 1 - by flanking markers 1579697 SS.SHR-(D13Rat63-D13Mit1)/Mco 13 9016906 82995569 1 - by flanking markers 13 5994833 77046787 1 - by flanking markers 1581555 rat Eae19 Experimental allergic encephalomyelitis QTL 19 15 4.7 34357 D15Mgh4 40106 D15Rat102 37584 D15Rat71 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) Experimental Autoimmune Encephalomyelitis 1549617 15716504 15 87456591 101499751 1 - by flanking markers 15 83349371 97700727 1 - by flanking markers 60997 737658 DA PVG.1AV1 15 83947714 98027710 1 - by flanking markers 15 76306099 90088744 1 - by flanking markers 1581557 rat Eae16 Experimental allergic encephalomyelitis QTL 16 8 3.8 36097 D8Rat56 36781 D8Rat11 37324 D8Rat75 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) CNS inflammation;abnormal voluntary movement Experimental Autoimmune Encephalomyelitis;Experimental Autoimmune Encephalomyelitis;Paresis;multiple sclerosis 629629 12517974 recessive 8 9505886 118551460 1 - by flanking markers 8 8294860 115338082 1 - by flanking markers 737657 737658 LEW.1AV1 PVG.1AV1 8 9531047 119211942 1 - by flanking markers 8 8462195 110921472 1 - by flanking markers 1581559 rat Eae18 Experimental allergic encephalomyelitis QTL 18 10 2.0E-5 35254 D10Rat2 35228 D10Rat29 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) Experimental Autoimmune Encephalomyelitis 1302800;2293859;2296064 11486278;16624898;18453595 Eae23 (sub_region);Eau9 (maps to same region) 10 67642304 110568486 1 - by flanking markers 10 23843272 68843272 4 - by one flank marker only 1331816 DA.ACI-(D10Rat2-D10Rat29)/Kini 10 67988218 110992091 1 - by flanking markers 10 107057622 107211142 4 - by one flank marker only 1581561 rat Eae22 Experimental allergic encephalomyelitis QTL 22 4 60421 D4Got135 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) Experimental Autoimmune Encephalomyelitis 1547849 15634914 4 190919460 235919460 5 - by peak with adj size 4 145746752 187126005 5 - by peak with adj size 60997 737658 DA PVG.1AV1 1581563 rat Uae33 Urinary albumin excretion QTL 33 6 10361 D6Wox13 11241 D6Mit3 66623 D6Uia5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 6 85163291 144273721 1 - by flanking markers 6 75049644 136451997 1 - by flanking markers 1579696 SS.SHR-(D6Wox13-D6Rat84)/Mco 6 75623393 136142742 1 - by flanking markers 6 72227641 130729205 1 - by flanking markers 1581565 rat Pur10 Proteinuria QTL 10 11 1.0E-4 37512 D11Rat50 39698 D11Rat67 37512 D11Rat50 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level proteinuria 1578520 16534143 11 50441007 90087331 1 - by flanking markers 11 45797929 84840963 1 - by flanking markers 1579691 SS.SHR-(D11Mgh3-D11Rat31)/Mco 11 47264023 86994547 1 - by flanking markers 11 44803318 82846466 1 - by flanking markers 1581566 rat Eae21 Experimental allergic encephalomyelitis QTL 21 4 6.2 43012 D14Rat113 60419 D4Got132 60418 D4Got131 body mass (VT:0001259) maximum body weight loss to initial body weight ratio (CMO:0001400) Experimental Autoimmune Encephalomyelitis 1547849 15634914 4 224422165 225566369 2 - by one flank and peak markers 4 162206044 162362144 2 - by one flank and peak markers 60997 737658 DA PVG.1AV1 4 157399119 158564471 2 - by one flank and peak markers 4 157680158 158841762 2 - by one flank and peak markers 1581568 rat Rf53 Renal function QTL 53 3 38686 D3Rat84 36759 D3Rat59 33808 D3Mit4 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) 1578626 16541022 3 64689438 176609927 1 - by flanking markers 3 53876762 163443738 1 - by flanking markers 1579678 1579700 ACI.FHH-(D3Wox2-D3Rat59)/Eur ACI.FHH-(D1Rat475-D1Rat90)(D3Rat84-D3Rat59)/Eur 3 58204463 170534769 1 - by flanking markers 3 56395968 161299569 1 - by flanking markers 1581569 rat Uae32 Urinary albumin excretion QTL 32 2 1.0E-4 35915 D2Rat61 66661 D2Mco18 38312 D2Rat179 urine protein amount (VT:0005160) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520;1625111 16534143;17504948 2 88594475 100298539 1 - by flanking markers 2 79796977 227150051 1 - by flanking markers 1579703 SS.SHR-(D2Rat61-D2Mco18)/Mco 2 68865414 80632096 1 - by flanking markers 2 78665619 219826953 2 - by one flank and peak markers 1581570 rat Eae17 Experimental allergic encephalomyelitis QTL 17 13 4.1 39436 D13Rat142 37180 D13Rat64 34833 D13Rat19 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) CNS inflammation;abnormal voluntary movement Experimental Autoimmune Encephalomyelitis;Experimental Autoimmune Encephalomyelitis;Paresis;multiple sclerosis 629629 12517974 dominant 13 17433838 113098593 1 - by flanking markers 13 28645448 106366082 1 - by flanking markers 737657 737658 LEW.1AV1 PVG.1AV1 13 12193394 108478121 1 - by flanking markers 13 8897350 101631289 1 - by flanking markers 1581572 rat Uae35 Urinary albumin excretion QTL 35 11 1.0E-4 37512 D11Rat50 39698 D11Rat67 37512 D11Rat50 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 11 50441007 90087331 1 - by flanking markers 11 45797929 84840963 1 - by flanking markers 1579691 SS.SHR-(D11Mgh3-D11Rat31)/Mco 11 47264023 86994547 1 - by flanking markers 11 44803318 82846466 1 - by flanking markers 1581573 rat Uae36 Urinary albumin excretion QTL 36 13 37240 D13Rat63 33923 D13Mit1 11231 D13Wox5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 13 14282000 87877309 1 - by flanking markers 13 25430276 80482326 1 - by flanking markers 1579697 SS.SHR-(D13Rat63-D13Mit1)/Mco 13 9016906 82995569 1 - by flanking markers 13 5994833 77046787 1 - by flanking markers 1581574 rat Eae20 Experimental allergic encephalomyelitis QTL 20 4 7.8 43012 D14Rat113 60419 D4Got132 34473 D4Mgh10 nervous system integrity trait (VT:0010566) percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047) Experimental Autoimmune Encephalomyelitis 1547849 15634914 4 219525801 225566369 2 - by one flank and peak markers 4 155974180 162362144 2 - by one flank and peak markers 60997 737658 DA PVG.1AV1 4 152482121 158564471 2 - by one flank and peak markers 4 153031106 158841762 2 - by one flank and peak markers 1581576 rat Pur7 Proteinuria QTL 7 2 1.0E-4 35915 D2Rat61 66661 D2Mco18 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 1578520 16534143 2 88594475 100298539 1 - by flanking markers 2 79796977 227150051 1 - by flanking markers 1579703 SS.SHR-(D2Rat61-D2Mco18)/Mco 2 68865414 80632096 1 - by flanking markers 1581577 rat Pur15 Proteinuria QTL 15 20 4.38 2.0E-4 23.6 37632 D20Rat49 35657 D20Rat5 34872 D20Rat3 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 1578625 16390874 20 10844023 21025734 1 - by flanking markers 20 8286533 18411969 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 20 8654341 18872273 1 - by flanking markers 20 8042410 17617956 1 - by flanking markers 1581578 rat Cm49 Cardiac mass QTL 49 2 4.9 0.01 34005 D2Mit8 35915 D2Rat61 34497 D2Mgh24 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 1578627 16286240 2609;61973;621276;628721;631398 Fgf2;Trpc3;Trpc4;Sclt1;Kcnmb2 2 88595515 169047256 1 - by flanking markers 2 148790600 227150249 1 - by flanking markers 60994 1302620 F344 SHR/Kyo 2 68866454 149614466 1 - by flanking markers 2 127447387 143657569 2 - by one flank and peak markers 1581580 rat Uae34 Urinary albumin excretion QTL 34 9 66431 D9Mco6 62516 D9Uia4 61287 D9Uia6 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 9 67265475 99638395 2 - by one flank and peak markers 9 59247627 105579863 1 - by flanking markers 1579702 SS.SHR-(D9Wox16-D9Rat64)/Mco 9 67451664 99920892 2 - by one flank and peak markers 9 62072275 96470995 2 - by one flank and peak markers 1582197 rat Gluco27 Glucose level QTL 27 14 3.4 6.0E-4 15.0 41986 D14Arb10 39030 D14Rat38 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582199 rat Insul5 Insulin level QTL 5 17 3.4 0.0119 12.0 40956 D17Rat107 38706 D17Rat84 40956 D17Rat107 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582201 rat Sffal2 Serum free fatty acids level QTL 2 14 4.0 2.0E-4 20.0 39030 D14Rat38 35897 D14Rat22 35897 D14Rat22 blood free fatty acid amount (VT:0001553) serum free fatty acids level (CMO:0000547) Metabolic Syndrome 1580752 15728334 14 102293972 106705037 1 - by flanking markers 14 99079814 102509397 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 102549183 106641756 1 - by flanking markers 14 92553886 95876975 1 - by flanking markers 1582203 rat Gluco19 Glucose level QTL 19 9 3.3 0.001 15.0 38036 D9Rat64 36027 D9Rat3 38036 D9Rat64 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Bw64 (interacts with) 9 98715385 107462796 1 - by flanking markers 9 91131330 99799902 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 9 99041068 107878528 1 - by flanking markers 9 92491589 100929786 1 - by flanking markers 1582204 rat Livw1 Liver weight QTL 1 1 3.6 3.0E-4 13.0 35591 D1Rat47 34399 D1Mgh9 41532 D1Rat280 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) increased liver weight Metabolic Syndrome 1580752 15728334 1 172296302 195235510 1 - by flanking markers 1 158511072 176855135 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 1 166100317 188289386 1 - by flanking markers 1 155422851 172949803 1 - by flanking markers 1582206 rat Kidm33 Kidney mass QTL 33 1 6.9 23.0 35851 D1Rat68 37902 D1Rat169 10768 D1Wox22 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight Metabolic Syndrome 1580752 15728334 1 212591076 251652933 1 - by flanking markers 1 193069836 229876997 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 1 205603081 244401301 1 - by flanking markers 1 188377360 224054420 1 - by flanking markers 1582208 rat Kidm32 Kidney mass QTL 32 17 3.9 0.0018 14.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) increased kidney weight Metabolic Syndrome 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582209 rat Gluco20 Glucose level QTL 20 14 3.8 5.0E-4 17.0 41986 D14Arb10 39030 D14Rat38 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Gluco24 (interacts with) 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582210 rat Bw71 Body weight QTL 71 3 3.3 0.0012 11.0 35589 D3Rat37 42664 D3Rat257 41296 D3Rat166 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 73270750 126355468 1 - by flanking markers 3 62558027 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 66711607 119830094 1 - by flanking markers 3 64655305 115665732 1 - by flanking markers 1582212 rat Livw2 Liver weight QTL 2 5 3.5 4.0E-4 12.0 38512 D5Rat80 39952 D5Rat158 60808 D5Wox25 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) increased liver weight Metabolic Syndrome 1580752 15728334 5 106525895 127710319 2 - by one flank and peak markers 5 103701215 125255195 2 - by one flank and peak markers intercross 728161 737899 PD/Cub BN/Cub 5 102498468 123852688 2 - by one flank and peak markers 5 99016066 119085810 2 - by one flank and peak markers 1582213 rat Insul6 Insulin level QTL 6 3 3.7 9.0E-4 13.0 38236 D3Rat213 41132 D3Rat143 41132 D3Rat143 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 Sffal1 (interacts with) intercross 728161 737899 PD/Cub BN/Cub 1582214 rat Stl21 Serum triglyceride level QTL 21 15 3.1 0.022 11.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582216 rat Bw65 Body weight QTL 65 3 6.3 19.0 41296 D3Rat166 42664 D3Rat257 41296 D3Rat166 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Insul8 (interacts with) 3 113470189 126355468 1 - by flanking markers 3 101359810 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 106900427 119830094 1 - by flanking markers 3 102200529 115665732 1 - by flanking markers 1582218 rat Bw74 Body weight QTL 74 3 3.9 0.0021 13.0 34146 D3Mgh6 42664 D3Rat257 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 61249840 126355468 1 - by flanking markers 3 50522618 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 119830094 1 - by flanking markers 3 53184593 115665732 1 - by flanking markers 1582219 rat Bw63 Body weight QTL 63 3 3.8 0.001 12.0 38328 D3Rat81 42664 D3Rat257 41296 D3Rat166 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 107333676 126355468 1 - by flanking markers 3 86696150 116023640 2 - by one flank and peak markers intercross 728161 737899 PD/Cub BN/Cub 3 100730984 119830094 1 - by flanking markers 3 96127817 115665732 1 - by flanking markers 1582221 rat Kidm30 Kidney mass QTL 30 3 3.5 8.0E-4 12.0 35589 D3Rat37 42664 D3Rat257 41296 D3Rat166 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) increased kidney weight Metabolic Syndrome 1580752 15728334 3 73270750 126355468 1 - by flanking markers 3 62558027 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 66711607 119830094 1 - by flanking markers 3 64655305 115665732 1 - by flanking markers 1582222 rat Epfw2 Epididymal fat weight QTL 2 8 3.2 5.0E-4 14.0 36161 D8Rat36 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 8 34506868 79506868 5 - by peak with adj size 8 34808657 79808657 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 8 35925594 80925594 5 - by peak with adj size 8 31737729 76737729 5 - by peak with adj size 1582224 rat Epfw4 Epididymal fat weight QTL 4 17 3.5 0.0058 12.0 40956 D17Rat107 38706 D17Rat84 40956 D17Rat107 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582225 rat Bw67 Body weight QTL 67 17 6.2 1.0E-4 19.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752;2312611 15728334;19697080 Bw64 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Bw91 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582226 rat Bw64 Body weight QTL 64 17 4.2 0.0017 13.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Gluco19 (interacts with);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582227 rat Gluco30 Glucose level QTL 30 15 3.6 3.0E-4 13.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Insul8 (interacts with) 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582228 rat Epfw3 Epididymal fat weight QTL 3 15 4.1 2.0E-4 14.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582229 rat Stl20 Serum triglyceride level QTL 20 8 3.2 0.0033 14.0 36872 D8Rat43 44411 D8Got72 36872 D8Rat43 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome 1580752 15728334 8 51241951 51710641 1 - by flanking markers 8 51577566 52065790 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 8 52644745 53117620 1 - by flanking markers 8 48630131 49147989 1 - by flanking markers 1582230 rat Bw78 Body weight QTL 78 5 3.2 0.0016 11.0 39952 D5Rat158 38338 D5Rat108 10454 D5Wox12 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased total body fat amount Metabolic Syndrome;obesity 1580752 15728334 5 127710120 137108002 1 - by flanking markers 5 125254995 134872385 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 5 123852489 133313852 1 - by flanking markers 5 119085612 128034027 1 - by flanking markers 1582232 rat Gluco25 Glucose level QTL 25 4 3.6 0.0023 16.0 35721 D4Rat76 37592 D4Rat141 37592 D4Rat141 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 4 150964994 210231755 1 - by flanking markers 4 84886545 151158853 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 4 86312589 146942261 1 - by flanking markers 4 85253748 148090731 1 - by flanking markers 1582233 rat Insul10 Insulin level QTL 10 3 5.4 0.0015 18.0 38236 D3Rat213 41132 D3Rat143 38236 D3Rat213 blood insulin amount (VT:0001560) serum insulin level times blood glucose level (CMO:0002040) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 intercross 728161 737899 PD/Cub BN/Cub 1582234 rat Gluco18 Glucose level QTL 18 1 3.4 3.0E-4 12.0 39320 D1Rat220 36432 D1Rat35 39320 D1Rat220 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 1 86959064 131959064 4 - by one flank marker only 1 79749065 124749065 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 1 85917265 130917265 4 - by one flank marker only 1 78479925 123479925 4 - by one flank marker only 1582235 rat Insul8 Insulin level QTL 8 16 3.3 0.0063 15.0 33848 D16Mit2 33652 D16Mit5 33848 D16Mit2 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 Bw65 (interacts with);Gluco30 (interacts with) 16 1 27496499 5 - by peak with adj size 16 1 26804456 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 16 1 27556253 5 - by peak with adj size 16 1 26727669 5 - by peak with adj size 1582236 rat Gluco22 Glucose level QTL 22 14 3.3 0.0164 15.0 41986 D14Arb10 39030 D14Rat38 41986 D14Arb10 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582237 rat Kidm34 Kidney mass QTL 34 4 4.0 1.0E-4 19.0 37592 D4Rat141 36486 D4Rat68 10049 D4Wox16 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) increased kidney weight Metabolic Syndrome 1580752 15728334 4 210231569 233267140 1 - by flanking markers 4 151158666 172169650 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 4 146942075 168998263 1 - by flanking markers 4 148090542 168069246 1 - by flanking markers 1582238 rat Bw68 Body weight QTL 68 3 3.2 0.0064 11.0 34146 D3Mgh6 42664 D3Rat257 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 3 61249840 126355468 1 - by flanking markers 3 50522618 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 119830094 1 - by flanking markers 3 53184593 115665732 1 - by flanking markers 1582239 rat Epfw1 Epididymal fat weight QTL 1 3 4.5 6.0E-4 16.0 34146 D3Mgh6 42664 D3Rat257 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) abnormal abdominal fat pad morphology Metabolic Syndrome 1580752 15728334 3 61249840 126355468 1 - by flanking markers 3 50522618 116023640 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 119830094 1 - by flanking markers 3 53184593 115665732 1 - by flanking markers 1582240 rat Sffal1 Serum free fatty acids level QTL 1 7 3.4 0.0021 12.0 38306 D7Rat97 35681 D7Rat5 35681 D7Rat5 blood free fatty acid amount (VT:0001553) serum free fatty acids level (CMO:0000547) Metabolic Syndrome 1580752 15728334 Insul6 (interacts with) 7 126176882 133771186 1 - by flanking markers 7 123574473 131350792 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 7 126463649 134098026 1 - by flanking markers 7 116677010 124049952 1 - by flanking markers 1582241 rat Bw70 Body weight QTL 70 17 4.6 3.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw73 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582242 rat Gluco28 Glucose level QTL 28 15 3.3 8.0E-4 11.0 35120 D15Rat6 34409 D15Mgh9 35120 D15Rat6 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582243 rat Bw66 Body weight QTL 66 8 3.4 0.0048 15.0 36161 D8Rat36 37324 D8Rat75 36161 D8Rat36 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 8 57006784 91507228 1 - by flanking markers 8 57308572 89558994 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 8 58425510 91990535 1 - by flanking markers 8 54237644 85365202 1 - by flanking markers 1582244 rat Bw79 Body weight QTL 79 15 4.0 2.0E-4 14.0 35120 D15Rat6 34409 D15Mgh9 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased total body fat amount Metabolic Syndrome;obesity 1580752 15728334 15 37103190 93131991 1 - by flanking markers 15 32638412 89569864 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 15 33219101 89640841 1 - by flanking markers 15 28030665 82262678 1 - by flanking markers 1582245 rat Bw73 Body weight QTL 73 17 4.6 4.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw76 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582246 rat Cm60 Cardiac mass QTL 60 2 5.8 24.0 35272 D2Rat19 33620 D2Mit6 35272 D2Rat19 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;Metabolic Syndrome 1580752 15728334 2 79200355 98153468 1 - by flanking markers 2 58117457 77630814 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 2 57715603 78466260 1 - by flanking markers 2 57605612 76539510 1 - by flanking markers 1582248 rat Insul7 Insulin level QTL 7 3 3.9 0.0041 14.0 41132 D3Rat143 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 intercross 728161 737899 PD/Cub BN/Cub 1582249 rat Bw77 Body weight QTL 77 3 3.2 0.0025 12.0 34146 D3Mgh6 35589 D3Rat37 34146 D3Mgh6 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) increased total body fat amount Metabolic Syndrome;obesity 1580752 15728334 3 61249840 73270928 1 - by flanking markers 3 50522618 62558206 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 3 54630948 66711785 1 - by flanking markers 3 53184593 64655484 1 - by flanking markers 1582250 rat Gluco26 Glucose level QTL 26 14 3.3 9.0E-4 15.0 41986 D14Arb10 35897 D14Rat22 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 106705037 1 - by flanking markers 14 78978644 102509397 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 106641756 1 - by flanking markers 14 73415323 95876975 1 - by flanking markers 1582251 rat Gluco24 Glucose level QTL 24 15 3.2 8.0E-4 11.0 35120 D15Rat6 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 Gluco20 (interacts with) 15 14603280 59603280 5 - by peak with adj size 15 10138595 55138595 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 15 10719191 55719191 5 - by peak with adj size 15 5530756 50530756 5 - by peak with adj size 1582252 rat Sual1 Serum uric acid level QTL 1 3 3.4 0.0123 12.0 38328 D3Rat81 41296 D3Rat166 38328 D3Rat81 blood uric acid amount (VT:0010302) blood uric acid level (CMO:0000501) Metabolic Syndrome 1580752 15728334 3 107333676 113470358 1 - by flanking markers 3 56359980 101359980 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 3 100730984 106900596 1 - by flanking markers 3 96127817 102200699 1 - by flanking markers 1582254 rat Kidm31 Kidney mass QTL 31 8 3.0 36161 D8Rat36 37324 D8Rat75 36161 D8Rat36 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) increased kidney weight Metabolic Syndrome 1580752 15728334 8 57006784 91507228 1 - by flanking markers 8 57308572 89558994 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 8 58425510 91990535 1 - by flanking markers 8 54237644 85365202 1 - by flanking markers 1582255 rat Gluco29 Glucose level QTL 29 14 3.1 0.0025 14.0 41986 D14Arb10 39030 D14Rat38 41986 D14Arb10 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 78146760 102294177 1 - by flanking markers 14 78978644 99080020 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 14 78172765 102549388 1 - by flanking markers 14 73415323 92554092 1 - by flanking markers 1582256 rat Insul9 Insulin level QTL 9 3 4.4 0.0016 15.0 38236 D3Rat213 41132 D3Rat143 41132 D3Rat143 blood insulin amount (VT:0001560) absolute change in serum insulin level (CMO:0002038) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 1580752 15728334 intercross 728161 737899 PD/Cub BN/Cub 1582257 rat Gluco21 Glucose level QTL 21 2 3.1 0.0035 11.0 41358 D2Rat217 36213 D2Rat40 66654 D2Mco14 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 2 141390480 189197988 1 - by flanking markers 2 121545310 163154358 1 - by flanking markers intercross 728161 737899 PD/Cub BN/Cub 2 121750419 169852800 1 - by flanking markers 2 118111229 157142209 1 - by flanking markers 1582258 rat Bw76 Body weight QTL 76 17 4.6 5.0E-4 16.0 40956 D17Rat107 38706 D17Rat84 38706 D17Rat84 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw64 (maps to same region);Bw67 (maps to same region);Bw70 (maps to same region);Bw73 (maps to same region);Epfw4 (maps to same region);Insul5 (maps to same region);Kidm32 (maps to same region) 17 11839249 23473342 1 - by flanking markers 17 15245341 29604237 1 - by flanking markers 728161 737899 PD/Cub BN/Cub 17 9730263 21491085 1 - by flanking markers 17 9201365 23653323 1 - by flanking markers 1582259 rat Gluco23 Glucose level QTL 23 14 3.1 8.0E-4 14.0 39030 D14Rat38 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome;hyperglycemia 1580752 15728334 14 79794074 115151701 5 - by peak with adj size 14 76579917 112194335 5 - by peak with adj size intercross 728161 737899 PD/Cub BN/Cub 14 80049285 115493446 5 - by peak with adj size 14 70053989 104886043 5 - by peak with adj size 1582260 rat Bw72 Body weight QTL 72 7 3.2 0.0043 15.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw69 (maps to same region);Bw75 (maps to same region) 7 20386476 44693197 1 - by flanking markers 7 1 41004865 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 7 20215583 44668493 1 - by flanking markers 7 15795565 38073970 1 - by flanking markers 1582261 rat Bw69 Body weight QTL 69 7 3.2 0.0048 14.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw72 (maps to same region);Bw75 (maps to same region) 7 20386476 44693197 1 - by flanking markers 7 1 41004865 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 7 20215583 44668493 1 - by flanking markers 7 15795565 38073970 1 - by flanking markers 1582262 rat Bw75 Body weight QTL 75 7 3.0 0.0038 14.0 36900 D7Rat37 37004 D7Rat181 36900 D7Rat37 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1580752 15728334 Bw69 (maps to same region);Bw72 (maps to same region) 7 20386476 44693197 1 - by flanking markers 7 1 41004865 4 - by one flank marker only intercross 728161 737899 PD/Cub BN/Cub 7 20215583 44668493 1 - by flanking markers 7 15795565 38073970 1 - by flanking markers 1598805 rat Memor8 Memory QTL 8 2 3.0 33747 D2Mit10 10200 D2Mgh11 1303105 Dear exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 2 177277106 223460027 1 - by flanking markers 2 155920709 197555821 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 157914311 204022555 1 - by flanking markers 2 150341585 189039377 1 - by flanking markers 1598807 rat Glom12 Glomerulus QTL 12 5 2.7 33678 D5Mit10 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 5 38938687 83938687 5 - by peak with adj size 5 35474610 80474610 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 34402409 79402409 5 - by peak with adj size 5 33215665 78215665 5 - by peak with adj size 1598809 rat Memor15 Memory QTL 15 X 4.4 40522 DXRat98 34783 DXRat21 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 X 122686596 144384190 2 - by one flank and peak markers X 9007287 160699376 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 110957467 155957467 5 - by peak with adj size X 103312877 148312877 5 - by peak with adj size 1598811 rat Bp291 Blood pressure QTL 291 11 1.9 34150 D11Mgh5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1581737 16720678 11 25137329 70137329 5 - by peak with adj size 11 20656936 65656936 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 11 21944229 66944229 5 - by peak with adj size 1598813 rat Memor9 Memory QTL 9 2 2.7 39040 D2Rat169 34864 D2Rat67 35613 D2Rat59 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 2 234324242 269740088 1 - by flanking markers 2 207443643 243502158 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 214870793 251212353 1 - by flanking markers 2 199341726 234244620 1 - by flanking markers 1598814 rat Mcs13 Mammary carcinoma susceptibility QTL 13 5 1.0E-4 1581996 D5Uwm65 1582030 D5Uwm66 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) Experimental Mammary Neoplasms 1559294 16266982 5 72838045 76105732 1 - by flanking markers 5 65553185 73080336 1 - by flanking markers 1581627 1581632 WF.WKY-(D5Uwm66-D5Uwm67)/Uwm WF.WKY-(D5Uwm65-D5Uwm60)/Uwm 5 68395096 71941113 1 - by flanking markers 5 63190890 69927503 1 - by flanking markers 1598816 rat Memor12 Memory QTL 12 20 2.4 37792 D20Rat29 38836 D20Rat37 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 20 5747478 50747478 4 - by one flank marker only 20 3055886 48055886 4 - by one flank marker only intercross 1582184 1582190 SR/JrHsd SS/JrHsd 20 4108956 49108956 4 - by one flank marker only 20 2606836 47606836 4 - by one flank marker only 1598817 rat Glom13 Glomerulus QTL 13 1 2.2 11201 D1Mgh11 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598819 rat Bp292 Blood pressure QTL 292 5 4.3 38916 D5Rat106 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737;7364997 16720678;22860086 Bp359 (sub_region) 5 137693256 177180328 5 - by peak with adj size 5 134356746 173096209 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 133943857 173707219 5 - by peak with adj size 5 127798274 166875058 5 - by peak with adj size 1598821 rat Rf55 Renal function QTL 55 1 6.3 36866 D1Rat73 36169 D1Rat89 41680 D1Rat376 renal blood flow trait (VT:2000006) ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239) 1579884 16303858 1 246113306 287349830 1 - by flanking markers 1 224420592 265343617 1 - by flanking markers intercross 629509 629520 FHH/EurMcwi FHH-Chr 1BN/Mcwi 1 238824734 279986079 1 - by flanking markers 1 218748008 257976495 1 - by flanking markers 1598823 rat Memor16 Memory QTL 16 9 1.9 40022 D9Rat152 39362 D9Rat92 37604 D9Rat76 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 9 24616151 54591542 1 - by flanking markers 9 18410299 47035878 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 25754320 54885226 1 - by flanking markers 9 22133322 49968732 1 - by flanking markers 1598824 rat Memor4 Memory QTL 4 8 2.5 33628 D8Mit6 41026 D8Rat153 36673 D8Rat49 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 8 11331331 56117827 1 - by flanking markers 8 9581132 56397678 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 8 11373267 57541668 1 - by flanking markers 8 9712220 53356647 1 - by flanking markers 1598826 rat Anxrr20 Anxiety related response QTL 20 18 3.04 36638 D18Rat14 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) anxiety disorder 1578499 16490266 18 45470403 87229863 5 - by peak with adj size 18 44524337 87265094 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 18 46319476 88201929 5 - by peak with adj size 18 41432971 83828827 5 - by peak with adj size 1598828 rat Glom14 Glomerulus QTL 14 15 2.5 40554 D15Rat93 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 15 44708822 89708822 5 - by peak with adj size 15 40091127 85091127 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 15 41068094 86068094 5 - by peak with adj size 15 34054139 79054139 5 - by peak with adj size 1598830 rat Bp288 Blood pressure QTL 288 1 3.5 11201 D1Mgh11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598832 rat Glom11 Glomerulus QTL 11 18 2.9 40918 D18Rat80 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 18 49752721 86965151 3 - by peak only 18 54435837 87265094 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598833 rat Bp295 Blood pressure QTL 295 2 3.5 1303105 Dear arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 2 181146893 226146893 5 - by peak with adj size 2 154238265 199238265 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 161745602 206745602 5 - by peak with adj size 2 147798556 192798556 5 - by peak with adj size 1598834 rat Memor11 Memory QTL 11 9 2.5 37604 D9Rat76 33999 D9Mit5 39362 D9Rat92 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 620218 Creb1 9 40929725 89766058 1 - by flanking markers 9 33496794 75633613 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 41261034 90024806 1 - by flanking markers 9 36962359 77814038 1 - by flanking markers 1598835 rat Anxrr18 Anxiety related response QTL 18 2 2.98 39118 D2Rat139 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) anxiety disorder 1578499 16490266 2 236268996 281268996 5 - by peak with adj size 2 210033012 255033012 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 2 217743855 262743855 5 - by peak with adj size 2 200990457 245990457 5 - by peak with adj size 1598837 rat Memor13 Memory QTL 13 X 3.2 36952 DXRat11 36735 DXRat32 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 X 44619917 154597545 2 - by one flank and peak markers X 62691290 160699376 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 44320616 158345622 2 - by one flank and peak markers X 41052407 146860749 2 - by one flank and peak markers 1598838 rat Bp290 Blood pressure QTL 290 2 1.9 10200 D2Mgh11 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 2 200959916 245959916 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 181522444 226522444 5 - by peak with adj size 2 166539266 211539266 5 - by peak with adj size 1598839 rat Rf56 Renal function QTL 56 1 10805 D1Mgh13 36169 D1Rat89 renal blood flow trait (VT:2000006) ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239) 1579884 16303858 1 274224224 287349830 1 - by flanking markers 1 252340389 265343617 1 - by flanking markers 1582193 FHH.FHH.1BN-(D1Mgh13-D1Rat89)/Mcwi 1 266793821 279986079 1 - by flanking markers 1 245907761 257976495 1 - by flanking markers 1598841 rat Memor7 Memory QTL 7 11 34150 D11Mgh5 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 11 25137329 70137329 5 - by peak with adj size 11 20656936 65656936 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 11 21944229 66944229 5 - by peak with adj size 1598842 rat Glom10 Glomerulus QTL 10 11 3.4 41734 D11Rat101 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 11 1 37535625 5 - by peak with adj size 11 1 35465693 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 11 1 33867429 5 - by peak with adj size 11 1 35331169 5 - by peak with adj size 1598843 rat Cm63 Cardiac mass QTL 63 6 2.6 37142 D6Rat80 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) decreased heart weight Cardiomegaly;Hypotension 1581737 16720678 6 1 23611623 5 - by peak with adj size 6 1 23802078 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 6 1 23620518 5 - by peak with adj size 6 1 39036266 5 - by peak with adj size 1598845 rat Mcs14 Mammary carcinoma susceptibility QTL 14 5 1.0E-4 1582044 D5Uwm67 1582002 D5Uwm61 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) Experimental Mammary Neoplasms 1559294;5684388 16266982;21205740 Mcs28 (sub_region);Mcs29 (sub_region) 5 82897463 87363048 1 - by flanking markers 5 79919505 84434576 1 - by flanking markers 1581641 WF.WKY-(D5Uwm68-D5Mit4)/Uwm 5 78777540 83269259 1 - by flanking markers 5 76369776 80813390 1 - by flanking markers 1598846 rat Bp293 Blood pressure QTL 293 5 3.9 35074 D5Rat23 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737;7364997 16720678;22860086 621139 Bsnd 5 87410667 132410667 5 - by peak with adj size 5 84392127 129392127 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 83424556 128424556 5 - by peak with adj size 5 79584860 124584860 5 - by peak with adj size 1598847 rat Cm62 Cardiac mass QTL 62 5 3.4 33680 D5Mit13 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 5 117929881 162929881 5 - by peak with adj size 5 115772027 160772027 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 114140832 159140832 5 - by peak with adj size 5 108845856 153845856 5 - by peak with adj size 1598849 rat Memor17 Memory QTL 17 9 2.2 39362 D9Rat92 36556 D9Rat10 33999 D9Mit5 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 9 54591357 76457525 1 - by flanking markers 9 47035692 68493058 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 54885041 76677636 1 - by flanking markers 9 49968546 71098346 1 - by flanking markers 1598850 rat Bp297 Blood pressure QTL 297 1 2.1 34868 D1Rat45 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 1 137638872 182638872 5 - by peak with adj size 1 123689796 168689796 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 131334152 176334152 5 - by peak with adj size 1 121006655 166006655 5 - by peak with adj size 1598852 rat Anxrr19 Anxiety related response QTL 19 10 5.07 39038 D10Rat104 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) anxiety disorder 1578499 16490266 additive 10 19219508 64219508 5 - by peak with adj size 10 19468218 64468218 5 - by peak with adj size 61105 61109 WKY/NHsd F344/NHsd 10 19402814 64402814 5 - by peak with adj size 10 18167841 63167841 5 - by peak with adj size 1598853 rat Memor3 Memory QTL 3 1 4.5 34868 D1Rat45 35525 D1Rat116 37184 D1Rat188 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 1 160138797 239429964 1 - by flanking markers 1 146189650 218467340 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 153834077 232297227 1 - by flanking markers 1 143506580 212458660 1 - by flanking markers 1598854 rat Memor10 Memory QTL 10 3 2.0 36584 D3Rat6 36759 D3Rat59 41322 D3Rat137 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 3 158307259 176609927 1 - by flanking markers 3 147990566 163443738 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 3 153412455 170534769 1 - by flanking markers 3 145956084 161299569 1 - by flanking markers 1598855 rat Bp294 Blood pressure QTL 294 12 3.5 33911 D12Mit6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 12 1 38944117 5 - by peak with adj size 12 1 35270263 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 12 1 36919844 5 - by peak with adj size 12 1 34851688 5 - by peak with adj size 1598856 rat Memor1 Memory QTL 1 X 1.9 40522 DXRat98 34783 DXRat21 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581736;1581615 14665699;16837653 X 122686596 144384190 2 - by one flank and peak markers X 9007287 160699376 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 110957467 155957467 5 - by peak with adj size X 103312877 148312877 5 - by peak with adj size 1598858 rat Cm61 Cardiac mass QTL 61 20 3.6 38836 D20Rat37 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598859 rat Cm66 Cardiac mass QTL 66 5 2.0 35074 D5Rat23 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 5 87410667 132410667 5 - by peak with adj size 5 84392127 129392127 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 83424556 128424556 5 - by peak with adj size 5 79584860 124584860 5 - by peak with adj size 1598861 rat Cm64 Cardiac mass QTL 64 5 2.9 38916 D5Rat106 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 5 137693256 177180328 5 - by peak with adj size 5 134356746 173096209 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 133943857 173707219 5 - by peak with adj size 5 127798274 166875058 5 - by peak with adj size 1598862 rat Glom9 Glomerulus QTL 9 2 3.5 38362 D2Rat161 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) abnormal mesangial cell morphology focal segmental glomerulosclerosis;kidney disease 1581737 16720678 2 115620268 160620268 5 - by peak with adj size 2 95764665 140764665 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 95946719 140946719 5 - by peak with adj size 2 92337601 137337601 5 - by peak with adj size 1598863 rat Cm65 Cardiac mass QTL 65 2 2.3 38362 D2Rat161 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Cardiomegaly;hypertension 1581737 16720678 2 115620268 160620268 5 - by peak with adj size 2 95764665 140764665 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 95946719 140946719 5 - by peak with adj size 2 92337601 137337601 5 - by peak with adj size 1598865 rat Bp296 Blood pressure QTL 296 2 2.1 38610 D2Rat143 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 2 103385014 148385014 5 - by peak with adj size 2 83736074 128736074 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 2 83656855 128656855 5 - by peak with adj size 2 81018907 126018907 5 - by peak with adj size 1598866 rat Bp287 Blood pressure QTL 287 1 5.1 34868 D1Rat45 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 1 137638872 182638872 5 - by peak with adj size 1 123689796 168689796 5 - by peak with adj size intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 131334152 176334152 5 - by peak with adj size 1 121006655 166006655 5 - by peak with adj size 1598868 rat Mcs12 Mammary carcinoma susceptibility QTL 12 5 1.0E-4 1581988 D5Uwm62 1582038 D5Uwm64 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) Experimental Mammary Neoplasms 1559294;1601189;5684386;6893465 16266982;17404222;21846333;1559294 Mcs23 (sub_region);Mcs24 (sub_region) 5 64739245 65886550 1 - by flanking markers 5 61238737 62299211 1 - by flanking markers 1581629 1581630 WF.WKY-(D5Wox8-D5Uwm62)/Uwm WF.WKY-(D5Uwm63-D5Uwm64)/Uwm 5 60225095 61370302 1 - by flanking markers 5 58973449 60051321 1 - by flanking markers 1598869 rat Memor6 Memory QTL 6 20 3.1 38180 D20Rat27 37792 D20Rat29 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615 16837653 20 32704500 57791882 2 - by one flank and peak markers 20 28656553 55268282 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 20 30913481 56205956 2 - by one flank and peak markers 20 29244388 54435887 2 - by one flank and peak markers 1598870 rat Bp289 Blood pressure QTL 289 20 2.4 38836 D20Rat37 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1581737 16720678 intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1598871 rat Memor5 Memory QTL 5 17 5.3 37402 D17Rat78 10348 D17Mit4 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581615;7394833 16837653;23469157 2402 Crem Memor18 (sub_region) 17 44407867 87106905 2 - by one flank and peak markers 17 47628673 94800809 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 17 42541872 85446768 2 - by one flank and peak markers 17 40540041 80387013 2 - by one flank and peak markers 1598872 rat Memor14 Memory QTL 14 X 4.5 36735 DXRat32 40522 DXRat98 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) abnormal learning/memory/conditioning;abnormal social investigation Memory Disorders;learning disability 1581615 16837653 X 101168680 144204814 2 - by one flank and peak markers X 1 118123026 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 101333032 146333032 4 - by one flank marker only X 93956491 138956491 4 - by one flank marker only 1598873 rat Memor2 Memory QTL 2 X 2.5 36111 DXRat8 36952 DXRat11 35331 DXRat25 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) abnormal object recognition memory;abnormal spatial learning Memory Disorders;learning disability 1581736;1581615 14665699;16837653 X 21859080 44620040 1 - by flanking markers X 41386788 62691414 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd X 21592623 44320739 1 - by flanking markers X 20990947 41052531 1 - by flanking markers 1598875 rat Bp286 Blood pressure QTL 286 3 2.0 9.0E-4 1582000 D3Mco44 66731 D2Mco36 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure;increased kidney weight Hypotension 1581650;2306800 17028336;19255363 68438;629471;1306721 Oprl1;Rgs19;Rtel1 Bp335 (interacts with) 2 65484323 110484323 4 - by one flank marker only 1582185 1582188 SS.SR-(D3Mco36-D3Got166)/Jr SS.SR-(D3Mco36-D3Mco46)/Jr 1598877 rat Bp285 Blood pressure QTL 285 3 1.5 0.03 1582056 D3Mco81 1582102 D3Mco75 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1581650;2306800 17028336;19255363 3781 Eef1a2 Bp335 (interacts with) 3 138104861 183104861 4 - by one flank marker only 3 122541511 167541511 4 - by one flank marker only 1582185 1582187 SS.SR-(D3Mco36-D3Got166)/Jr SS.SR-(D3Mco24-D3Got130)/Jr 3 128986468 173986468 4 - by one flank marker only 3 120538241 165538241 4 - by one flank marker only 1599689 rat Iddm24 Insulin dependent diabetes mellitus QTL 24 8 4.72 0.001 40246 D8Rat121 39624 D8Rat118 41446 D8Rat119 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased urine glucose level;insulitis Experimental Diabetes Mellitus 1624306;2299158 17389329 8 121647985 126827827 1 - by flanking markers 8 118705293 123876328 1 - by flanking markers 1599674 BBDP.WF-(D8Rat59-D8Sunn1467)/Sunn 8 120870965 127609447 2 - by one flank and peak markers 8 112834440 118649220 2 - by one flank and peak markers 1600358 rat Mamtr5 Mammary tumor resistance QTL 5 5 40716 D5Rat124 39276 D5Rat114 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence;increased tumor growth/size Experimental Mammary Neoplasms;adenocarcinoma 1599390;1643011 17230524;17597107 5 23635353 68635353 4 - by one flank marker only 5 19206257 64206257 4 - by one flank marker only 1599763 SPRD.WKY-(D5Rat190-D5Rat114)/Ibmm 5 18847913 63847913 4 - by one flank marker only 5 18873947 63873947 4 - by one flank marker only 1600360 rat Mcs16 Mammary carcinoma susceptibility QTL 16 1 2.4 39666 D1Rat246 36626 D1Rat15 39666 D1Rat246 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 1 3564603 45053773 1 - by flanking markers 1 2436832 37799020 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 1 1868045 43724576 1 - by flanking markers 1 2244390 43433040 1 - by flanking markers 1600362 rat Mcs19 Mammary carcinoma susceptibility QTL 19 5 2.5 40574 D5Rat196 41560 D5Rat153 40574 D5Rat196 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 5 107265415 111096270 1 - by flanking markers 5 103956411 108590465 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 5 103265614 107119704 1 - by flanking markers 5 99485997 103690167 1 - by flanking markers 1600363 rat Hc6 Hypercalciuria QTL 6 1 2.7 35741 D1Rat32 33830 D1Mit32 37902 D1Rat169 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) increased urine calcium level;nephrolithiasis Kidney Calculi 1582396 16611718 3562;620771;727801 Rgs10;Ptpre;Nadsyn1 1 202649657 272443364 1 - by flanking markers 1 112148733 250430505 1 - by flanking markers 1598804 WKY.GHS-(D1Rat32-D1Mit32) 1 195598053 265002735 1 - by flanking markers 1 203995416 244113296 2 - by one flank and peak markers 1600365 rat Mcs20 Mammary carcinoma susceptibility QTL 20 9 3.0 35623 D9Rat41 39246 D9Rat63 41772 D9Rat158 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 9 14477917 46933391 1 - by flanking markers 9 8991206 39691794 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 9 15554901 47249201 1 - by flanking markers 9 13533770 42791750 1 - by flanking markers 1600367 rat Mcs15 Mammary carcinoma susceptibility QTL 15 10 4.5 44808 D10Got124 34128 D10Mgh1 35627 D10Rat12 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1581951 16568087 2218 Brca1 10 88338460 107179398 2 - by one flank and peak markers 10 89575059 108822775 2 - by one flank and peak markers 1598797 WF.WKY-(D10Got124-D10Rat187)/Uwm 10 88544136 107545372 2 - by one flank and peak markers 10 85565469 103884409 2 - by one flank and peak markers 1600369 rat Hcas8 Hepatocarcinoma susceptibility QTL 8 16 33652 D16Mit5 40052 D16Rat75 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) increased hepatocyte proliferation;increased hepatoma incidence Experimental Liver Neoplasms 1599590 17079458 16 1 24112769 4 - by one flank marker only 16 1 24132402 4 - by one flank marker only 1599755 F344.BN-(D16Mit5-D16Rat75) 16 1 24228366 4 - by one flank marker only 16 1 22477621 4 - by one flank marker only 1600371 rat Mcs21 Mammary carcinoma susceptibility QTL 21 10 3.0 39102 D10Rat71 37986 D10Rat116 39102 D10Rat71 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) increased mammary adenocarcinoma incidence;increased tumor incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;2302423;1581951 16596452;19052818;16568087 10 29855098 53807373 1 - by flanking markers 10 29541648 54220239 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 10 30021354 54057745 1 - by flanking markers 10 28875650 52200160 1 - by flanking markers 1600373 rat Mamtr6 Mammary tumor resistance QTL 6 18 40096 D18Rat102 39278 D18Rat44 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased incidence of tumors by chemical induction;increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599390;1643011;2302423 17230524;17597107;19052818 18 20030289 86114102 1 - by flanking markers 18 19892650 86863412 1 - by flanking markers 1599760 SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm 18 20285758 87080053 1 - by flanking markers 18 19278901 83218561 1 - by flanking markers 1600374 rat Mcs17 Mammary carcinoma susceptibility QTL 17 1 3.0 38954 D1Rat181 35372 D1Rat88 35372 D1Rat88 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 1 222579288 267579288 4 - by one flank marker only 1 202763018 247763018 4 - by one flank marker only backcross 737895 737962 WKY/Ztm SPRD/Ztm 1 215684498 260684498 4 - by one flank marker only 1 197670404 242670404 4 - by one flank marker only 1600375 rat Mcs22 Mammary carcinoma susceptibility QTL 22 18 3.3 37568 D18Rat55 36638 D18Rat14 36638 D18Rat14 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) increased mammary adenocarcinoma incidence;increased tumor incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;2302423;1581951 16596452;19052818;16568087 18 53346348 67970489 1 - by flanking markers 18 54856551 67024547 1 - by flanking markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 18 54108375 68819562 1 - by flanking markers 18 52539763 63933058 1 - by flanking markers 1600376 rat Arunc5 Aerobic running capacity QTL 5 3 0.21 40204 D3Rat233 34411 D3Mgh14 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) increased aerobic running capacity 1598978 17179209 3 85198834 130198834 4 - by one flank marker only 3 73863223 118863223 4 - by one flank marker only 1599769 COP.DA-(D3Rat233-D3Mgh14)/Mco 3 78700444 123700444 4 - by one flank marker only 3 73376539 118376539 4 - by one flank marker only 1600378 rat Arunc4 Aerobic running capacity QTL 4 16 0.03 36892 D16Rat12 38444 D16Rat90 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) increased aerobic running capacity 1598978 17179209 620427;1306769 Pdlim3;Tm2d2 16 1084304 85597057 1 - by flanking markers 16 350121 85734479 1 - by flanking markers 1599764 COP.DA-(D16Rat12-D16Rat90)/Mco 16 1090054 86162972 1 - by flanking markers 16 380245 80345693 1 - by flanking markers 1600379 rat Mcs18 Mammary carcinoma susceptibility QTL 18 2 2.6 33822 D2Mit29 37018 D2Rat14 36089 D2Rat4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 1599317;1581951 16596452;16568087 2 5396621 61826080 1 - by flanking markers 2 5601528 35247994 2 - by one flank and peak markers backcross 737895 737962 WKY/Ztm SPRD/Ztm 2 5417336 42777046 1 - by flanking markers 2 7887772 42804738 1 - by flanking markers 1600380 rat Niddm70 Non-insulin dependent diabetes mellitus QTL 70 1 3.1 8.0E-4 11.0 34244 D1Mgh10 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 1598974 16783636 1 201410613 246410613 5 - by peak with adj size 1 181780342 226780342 5 - by peak with adj size 1600339 BN.GK-(D1Wox18-D1Got254)/Ox 1 194554354 239554354 5 - by peak with adj size 1 176550523 221550523 5 - by peak with adj size 1600382 rat Edcs3 Endometrial carcinoma susceptibility QTL3 20 3.5 0.003 11207 D20Wox5 37490 D20Rat21 11207 D20Wox5 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 2252;3020;3817;3818;3876 Ddr1;Lta;Tap1;Tap2;Tnf 20 4113091 5240382 1 - by flanking markers 20 1675005 2780205 1 - by flanking markers intercross 737945 737947 BN/Han BDII/Ztm 20 1 25653396 5 - by peak with adj size 20 1 25159026 5 - by peak with adj size 1600384 rat Niddm66 Non-insulin dependent diabetes mellitus QTL 66 1 5.0E-6 9.6 1600324 D1Swe8 43448 D1Got251 10097 D1Smu2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 1599587;2316628;2312611 16951059;19965390;19697080 additive Gluco51 (maps to same region) 1 281763458 282550389 1 - by flanking markers 1 259866528 260641846 1 - by flanking markers 1600342 1600344 F344.GK-(D1Got250-D1Rat90)/Swe F344.GK-(D1Rat175-D1Rat90)/Swe 1 274353782 275138914 1 - by flanking markers 1 252645447 253439819 1 - by flanking markers 1600386 rat Calcic2 Intracellular calcium level QTL 2 12 0.001 34729 D12Mgh5 34373 D12Mgh6 platelet physiology trait (VT:0005464) platelet intracellular calcium level (CMO:0000922) cardiac hypertrophy hypertension 1599588 17261463 2174 Atp2a2 12 33647399 54450796 4 - by one flank marker only 12 29130180 42387195 1 - by flanking markers 1600338 SHR.F344-(D12Mgh5-D12Mgh6)/Snk 12 31723565 52716770 4 - by one flank marker only 12 28064433 46669029 4 - by one flank marker only 1600388 rat Niddm67 Non-insulin dependent diabetes mellitus QTL 67 1 5.84 4.0E-6 19.0 43370 D1Wox8 43454 D1Got254 11060 D1Wox23 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 1598974 16783636 1 220370900 286341689 1 - by flanking markers 1 200882874 264367394 1 - by flanking markers intercross 737972 4889464 BN/Crl GK/Ox 1 213476630 278978026 1 - by flanking markers 1 195804352 257091168 1 - by flanking markers 1600390 rat Niddm64 Non-insulin dependent diabetes mellitus QTL 64 1 0.003 4.0 43443 D1Got247 1600322 D1Swe3 1600318 D1Swe2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 1599587;2312611 16951059;19697080 1310974 Sorcs3 Gluco51 (maps to same region) 1 276009949 276520579 1 - by flanking markers 1 254291806 254810043 1 - by flanking markers 1600344 1600345 F344.GK-(D1Rat175-D1Rat90)/Swe F344.GK-(D1Rat83-D1Rat376)/Swe 1 268570074 269078983 1 - by flanking markers 1 247683763 248192604 1 - by flanking markers 1600391 rat Edcs2 Endometrial carcinoma susceptibility QTL2 12 3.5 0.01 34268 D12Mgh4 41956 D12Arb13 33911 D12Mit6 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 2559;3124 Epo;Muc17 12 10334345 32251246 1 - by flanking markers 12 7382953 27853771 1 - by flanking markers intercross 737945 737947 BN/Han BDII/Ztm 12 8249608 20590080 2 - by one flank and peak markers 12 6833190 17870186 2 - by one flank and peak markers 1600392 rat Bw123 Body weight QTL 123 1 0.001 5.1 34935 D1Rat83 37398 D1Rat175 34935 D1Rat83 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight type 2 diabetes mellitus 1599587;2312611 16951059;19697080 additive Bw85 (maps to same region) 1 251517075 290094216 5 - by peak with adj size 1 229633779 267910886 5 - by peak with adj size 1600345 F344.GK-(D1Rat83-D1Rat376)/Swe 1 244087148 282763074 5 - by peak with adj size 1 223201027 260522016 5 - by peak with adj size 1600394 rat Edcs1 Endometrial carcinoma susceptibility QTL1 11 2.9 0.04 34130 D11Mgh6 33899 D11Mit4 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 2139;1584977 App;Ets2 11 22660494 28704954 2 - by one flank and peak markers 11 19445919 24982397 2 - by one flank and peak markers intercross 737947 737962 BDII/Ztm SPRD/Ztm 11 19016272 25069932 2 - by one flank and peak markers 11 18976208 24697116 2 - by one flank and peak markers 1600395 rat Niddm69 Non-insulin dependent diabetes mellitus QTL 69 1 4.14 2.0E-4 13.0 43370 D1Wox8 43454 D1Got254 70473 D1mD19Mit11 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 1598974 16783636 1 220370900 286341689 1 - by flanking markers 1 200882874 264367394 1 - by flanking markers intercross 737972 4889464 BN/Crl GK/Ox 1 213476630 278978026 1 - by flanking markers 1 195804352 257091168 1 - by flanking markers 1600396 rat Niddm68 Non-insulin dependent diabetes mellitus QTL 68 1 4.97 3.0E-4 13.0 43370 D1Wox8 43454 D1Got254 10580 D1Smu5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 1598974 16783636 1 220370900 286341689 1 - by flanking markers 1 200882874 264367394 1 - by flanking markers 1600339 BN.GK-(D1Wox18-D1Got254)/Ox 1 213476630 278978026 1 - by flanking markers 1 195804352 257091168 1 - by flanking markers 1600397 rat Edcs4 Endometrial carcinoma susceptibility QTL 4 1 2.2 33646 D1Mit4 10674 D1Mgh12 40028 D1Rat301 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 1 248611683 270717037 2 - by one flank and peak markers 1 221868279 247322277 2 - by one flank and peak markers intercross 737947 737962 BDII/Ztm SPRD/Ztm 1 226706329 271706329 5 - by peak with adj size 1 206081677 251081677 5 - by peak with adj size 1600398 rat Edcs5 Endometrial carcinoma susceptibility QTL 5 17 2.2 45485 D17Wox9 33707 D17Mit5 34120 D17Mgh5 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) increased endometrial carcinoma incidence Endometrial Neoplasms;Endometrioid Carcinomas 1599853;1599856 15796960;11745480 17 63969458 76361876 1 - by flanking markers 17 65900398 82125463 1 - by flanking markers backcross 737947 737962 BDII/Ztm SPRD/Ztm 17 62195703 74702206 1 - by flanking markers 17 57246723 70852846 1 - by flanking markers 1600399 rat Niddm65 Non-insulin dependent diabetes mellitus QTL 65 1 0.004 3.9 1600320 D1Swe4 41680 D1Rat376 60230 D1Got244 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) type 2 diabetes mellitus 1599587;2312611 16951059;19697080 1305910 Sorcs1 Gluco51 (maps to same region) 1 277075545 277574233 2 - by one flank and peak markers 1 255386328 255970652 2 - by one flank and peak markers 1600346 F344.GK-(D1Swe4-D1Rat85)/Swe 1 269633949 270137485 2 - by one flank and peak markers 1 248746112 249254376 2 - by one flank and peak markers 1641833 rat Alc21 Alcohol consumption QTL 21 4 8.6 1.0E-4 34282 D4Mgh15 34902 D4Rat55 35409 D4Rat34 drinking behavior trait (VT:0001422) ethanol drink intake rate (CMO:0001407) increased alcohol consumption alcohol use disorder;alcohol use disorder 61483;1578304;8662401 9660316;16470346;24611993 3197;70547 Npy;Crhr2 additive 4 55118586 190188644 1 - by flanking markers 4 54879077 127941994 1 - by flanking markers intercross 634380 634381 iP/Iusm iNP/Iusm 4 55375865 125671711 1 - by flanking markers 4 56698790 126192555 1 - by flanking markers 1641885 rat Alcrsp9 Alcohol response QTL 9 7 41106 D7Rat147 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439 15608595 7 31391058 76391058 5 - by peak with adj size 7 27664404 72664404 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 7 31381529 76381529 5 - by peak with adj size 7 24099606 69099606 5 - by peak with adj size 1641887 rat Alcrsp14 Alcohol response QTL 14 15 36313 D15Rat5 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 15 2470818 47470818 5 - by peak with adj size 15 1 44953103 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 15 1 43521446 5 - by peak with adj size 15 1 42356671 5 - by peak with adj size 1641889 rat Colcr6 Colorectal carcinoma resistance QTL 6 15 2.9 0.0126 34222 D15Mgh8 38178 D15Rat63 38178 D15Rat63 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 15 84794264 112515839 1 - by flanking markers 15 80361961 107849649 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 15 81255292 109133904 1 - by flanking markers 15 73690518 99794247 1 - by flanking markers 1641891 rat Alcrsp17 Alcohol response QTL 17 2 35162 D2Rat38 34858 D2Rat69 38054 D2Rat138 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 2 175354307 272813962 1 - by flanking markers 2 155101972 247295816 1 - by flanking markers intercross 1641861 HAS.LAS-(D2Rat53-D2Rat138)/Rar 2 155965557 254121739 1 - by flanking markers 2 149559561 249053267 2 - by one flank and peak markers 1641893 rat Alcrsp7 Alcohol response QTL 7 20 38324 D20Rat32 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 20 1 28385430 5 - by peak with adj size 20 1 27477794 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 20 1 26305996 5 - by peak with adj size 20 1 27339237 5 - by peak with adj size 1641894 rat Alcrsp12 Alcohol response QTL 12 9 39362 D9Rat92 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 9 32091449 77091449 5 - by peak with adj size 9 24535785 69535785 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 9 32385133 77385133 5 - by peak with adj size 9 27468639 72468639 5 - by peak with adj size 1641895 rat Bp298 Blood pressure QTL 298 1 60784 D1Wox29 11359 D1Arb21 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal baroreceptor physiology;decreased mean systemic arterial blood pressure Hypotension;Myocardial Ischemia 1600255;2302408 17327494;19047583 1 131822204 206277202 1 - by flanking markers 1 124614679 187092492 1 - by flanking markers 1600343 SHRSP.WKY-(D1Wox29-D1Arb21)/Izm 1 130779148 199254774 1 - by flanking markers 1 123350408 182418476 1 - by flanking markers 1641897 rat Alcrsp1 Alcohol response QTL 1 1 36432 D1Rat35 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 1334439;2317807 15608595;19500156 Alcrsp19 (sub_region) 1 109458992 154458992 5 - by peak with adj size 1 102248992 147248992 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 1 108417193 153417193 5 - by peak with adj size 1 100979852 145979852 5 - by peak with adj size 1641898 rat Colcr4 Colorectal carcinoma resistance QTL4 6 3.71 7.0E-4 35683 D6Rat39 40044 D6Rat154 41064 D6Rat134 intestine integrity trait (VT:0010554) well differentiated malignant colorectal tumor surface area measurement (CMO:0002077) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 6 31405370 75363063 1 - by flanking markers 6 33021033 64955579 2 - by one flank and peak markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 6 21515302 65784818 1 - by flanking markers 6 20338777 62613667 1 - by flanking markers 1641900 rat Alcrsp11 Alcohol response QTL 11 14 39030 D14Rat38 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 14 79794074 115151701 5 - by peak with adj size 14 76579917 112194335 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 14 80049285 115493446 5 - by peak with adj size 14 70053989 104886043 5 - by peak with adj size 1641901 rat Alcrsp6 Alcohol response QTL 6 13 36506 D13Rat32 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 13 62795692 107795692 5 - by peak with adj size 13 55689252 100689252 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 13 57903612 102903612 5 - by peak with adj size 13 52362171 97362171 5 - by peak with adj size 1641902 rat Colcr7 Colorectal carcinoma resistance QTL 7 17 3.35 0.0044 35116 D17Rat53 38348 D17Rat59 35116 D17Rat53 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 17 512253 25386885 1 - by flanking markers 17 7696509 27724805 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 17 519770 23422380 1 - by flanking markers 17 2115149 21881669 1 - by flanking markers 1641903 rat Alcrsp3 Alcohol response QTL 3 5 39186 D5Rat70 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 5 17946863 62946863 5 - by peak with adj size 5 13886258 58886258 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 5 13288888 58288888 5 - by peak with adj size 5 12689285 57689285 5 - by peak with adj size 1641904 rat Alcrsp4 Alcohol response QTL 4 6 35659 D6Rat18 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 6 80668101 125668101 5 - by peak with adj size 6 70874239 115874239 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 6 71206251 116206251 5 - by peak with adj size 6 67262953 112262953 5 - by peak with adj size 1641905 rat Colcr1 Colorectal carcinoma resistance QTL 1 4 4.3 3.0E-4 38118 D4Rat133 38908 D4Rat126 38118 D4Rat133 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 4 1 26562180 4 - by one flank marker only 4 1 26178440 4 - by one flank marker only intercross 737892 1641864 ACI/SegHsd WF/CrCrli 4 1 26654881 4 - by one flank marker only 4 1 29494328 4 - by one flank marker only 1641906 rat Alcrsp16 Alcohol response QTL 16 13 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 intercross 1578696 1578700 LAS1 HAS1 1641908 rat Teswt1 Testicular weight QTL 1 7 3.28 33648 D7Mit5 33969 D7Mit4 testis mass (VT:1000644) both testes wet weight (CMO:0000175) decreased testis weight 1625009;8662361 16651691;24448715 3130 Myc 7 88393619 104437717 1 - by flanking markers 7 85089895 100273797 1 - by flanking markers intercross 629500 LEXF/Stm 7 88365265 103867802 1 - by flanking markers 7 80221299 94811326 1 - by flanking markers 1641910 rat Colcr3 Colorectal carcinoma resistance QTL 3 18 5.02 7.0E-6 38010 D18Rat46 38350 D18Rat38 38010 D18Rat46 intestine integrity trait (VT:0010554) poorly differentiated malignant colorectal tumor number (CMO:0002076);poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 2123 Apc 18 2495834 22914913 1 - by flanking markers 18 2571631 22807391 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 18 2477096 23184414 1 - by flanking markers 18 2249477 22066430 1 - by flanking markers 1641911 rat Alcrsp13 Alcohol response QTL 13 9 36157 D9Rat31 response to alcohol trait (VT:0010489) brain neurotensin receptor 1 density (CMO:0002068) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 9 1217127 46217127 5 - by peak with adj size 9 1 39963583 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 9 2355722 47355722 5 - by peak with adj size 9 1 43718459 5 - by peak with adj size 1641912 rat Alcrsp18 Alcohol response QTL 18 5 39186 D5Rat70 35651 D5Rat37 39402 D5Rat139 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 5 40446731 151220567 1 - by flanking markers 5 36386126 148460381 1 - by flanking markers intercross 1641854 HAS.LAS-(D5Rat70-D5Rat37)/Rar 5 35788756 147487820 1 - by flanking markers 5 35189153 141643988 1 - by flanking markers 1641913 rat Colcr2 Colorectal carcinoma resistance QTL 2 15 6.57 0.0197 38922 D15Rat38 37106 D15Rat31 37106 D15Rat31 intestine integrity trait (VT:0010554) colorectal tumor number (CMO:0001794);poorly differentiated malignant colorectal tumor number (CMO:0002076) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 15 2310393 30216604 1 - by flanking markers 15 2306220 25410881 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 15 2327877 26288802 1 - by flanking markers 15 2266368 22711984 1 - by flanking markers 1641915 rat Colcr9 Colorectal carcinoma resistance QTL 9 20 2.97 0.0024 35212 D20Rat13 33876 D20Mit4 35212 D20Rat13 intestine integrity trait (VT:0010554) benign colorectal tumor number (CMO:0001795) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 20 27567584 36993999 1 - by flanking markers 20 1 32560683 4 - by one flank marker only intercross 737892 1641864 ACI/SegHsd WF/CrCrli 20 2999707 47999707 5 - by peak with adj size 20 1530655 46530655 5 - by peak with adj size 1641917 rat Colcr5 Colorectal carcinoma resistance QTL 5 6 3.18 9.0E-4 34098 D6Mgh3 37076 D6Rat1 39052 D6Rat101 intestine integrity trait (VT:0010554) benign colorectal tumor number (CMO:0001795) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 6 136507025 153672040 1 - by flanking markers 6 127683728 144152572 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 6 127286494 144745573 1 - by flanking markers 6 122549046 137801795 1 - by flanking markers 1641918 rat Alcrsp15 Alcohol response QTL 16 12 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1600610;1334439 16953387;15608595 intercross 1578696 1578700 LAS1 HAS1 1641919 rat Alc22 Alcohol consumption QTL 22 4 5.0E-4 37438 D4Rat119 34902 D4Rat55 drinking behavior trait (VT:0001422) ethanol drink intake rate (CMO:0001407) increased alcohol consumption alcohol use disorder 1578304;1624272;8662401;7394775 16470346;17451403;24611993;23312492 2092;3197;3729;68368;70547;735049;1307836;1308501;1310949;1311418 Akr1b1;Npy;Snca;Grid2;Crhr2;Dgki;Zfp212;Ppm1k;Sos1;Baiap1 additive Bw126 (sub_region) 4 145188644 190188644 4 - by one flank marker only 4 62832008 127941994 1 - by flanking markers 1641877 NP.P-(D4Rat119-D4Rat55)/Iusm 4 62947687 125671711 1 - by flanking markers 4 81192555 126192555 4 - by one flank marker only 1641920 rat Colcs1 Colorectal carcinoma susceptibility QTL 1 5 2.99 0.0055 39406 D5Rat205 35823 D5Rat50 39250 D5Rat74 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 5 132161806 177161806 4 - by one flank marker only intercross 737892 1641864 ACI/SegHsd WF/CrCrli 5 128687766 173687766 4 - by one flank marker only 5 121846814 166846814 4 - by one flank marker only 1641922 rat Alcrsp8 Alcohol response QTL 8 5 39186 D5Rat70 39402 D5Rat139 39186 D5Rat70 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439;1600610 15608595;16953387 5 40446731 74918556 1 - by flanking markers 5 36386126 71377566 1 - by flanking markers intercross 1578696 1578700 LAS1 HAS1 5 35788756 70742105 1 - by flanking markers 5 35189153 68564008 1 - by flanking markers 1641923 rat Colcr8 Colorectal carcinoma resistance QTL 8 18 3.1 0.0014 38350 D18Rat38 37738 D18Rat57 37738 D18Rat57 intestine integrity trait (VT:0010554) poorly differentiated malignant colorectal tumor number (CMO:0002076) increased colon adenoma incidence Colorectal Neoplasms 1625309;5128610 17510081;21390212 18 22914726 53100658 1 - by flanking markers 18 22807203 54605912 1 - by flanking markers intercross 737892 1641864 ACI/SegHsd WF/CrCrli 18 23184227 53861431 1 - by flanking markers 18 22066242 52293055 1 - by flanking markers 1641925 rat Alcrsp2 Alcohol response QTL 2 2 35162 D2Rat38 38054 D2Rat138 35313 D2Rat53 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 2 175354307 256283467 1 - by flanking markers 2 155101972 230157845 1 - by flanking markers intercross 1578696 1578700 LAS1 HAS1 2 155965557 237742948 1 - by flanking markers 2 149559561 221167075 1 - by flanking markers 1641926 rat Teswt2 Testicular weight QTL 2 1 2.82 33753 D1Mit5 10445 D1Wox25 testis mass (VT:1000644) both testes wet weight (CMO:0000175) decreased testis weight 1625009 16651691 1 222606650 266214325 1 - by flanking markers 1 202790380 247790380 4 - by one flank marker only intercross 629500 LEXF/Stm 1 215711860 258765521 1 - by flanking markers 1 197697768 238755659 1 - by flanking markers 1641927 rat Alcrsp10 Alcohol response QTL 10 11 35323 D11Rat24 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) alcohol preference alcohol-induced mental disorder 1334439 15608595 11 12960007 57960007 5 - by peak with adj size 11 9165656 54165656 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 11 9351274 54351274 5 - by peak with adj size 11 8436674 53436674 5 - by peak with adj size 1641928 rat Alcrsp5 Alcohol response QTL 5 12 39332 D12Rat52 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) alcohol preference;impaired righting response alcohol-induced mental disorder 1334439 15608595 12 20209592 54450796 5 - by peak with adj size 12 13948769 46782294 5 - by peak with adj size intercross 1578696 1578700 LAS1 HAS1 12 18342477 52716770 5 - by peak with adj size 12 12812385 46669029 5 - by peak with adj size 1642290 rat Bp299 Blood pressure QTL 299 10 1642083 D10Mco88 1642081 D10Mco89 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1599269;1642602 17218081;17893371 69069;621743 Ccl5;Ddx52 Bp300 (sub_region);Bp301 (sub_region);Bp302 (sub_region) 10 70280918 71638303 1 - by flanking markers 10 71513116 72685167 1 - by flanking markers intercross 1642272 SS.LEW-(D10Mco84-D10Got93)/Mco 10 70647089 71727943 1 - by flanking markers 10 68230134 69282520 1 - by flanking markers 1642976 rat Bp301 Blood pressure QTL 301 10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial blood pressure hypertension 1642602;2303163 17893371;8829824 727916;1309875;1585229 Rffl;Lig3;LOC688779 Bp299 (sub_region) intercross 1642968 SS.LEW-(D10Mco84-D10Rat58)/Mco 1642980 rat Bp300 Blood pressure QTL 300 10 44761 D10Got88 66492 D10Mco62 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 1642602;2303163 17893371;8829824 3647;619957;620441;1303147;1303200;1566204;1596171 Ccl3;Wfdc18;Ccl4;Wfdc21;Ccl6;Heatr6;LOC689133 Bp299 (sub_region) 10 70433545 70763527 1 - by flanking markers 10 71662573 72063491 1 - by flanking markers intercross 1642969 SS.LEW-(D10Mco84-D10Mco134)/Mco 10 70800069 112626471 4 - by one flank marker only 10 68383129 107211142 4 - by one flank marker only 1642982 rat Bp302 Blood pressure QTL 302 10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial blood pressure Hypotension 1642602;2303163 17893371;8829824 71048;620757;1310708;1561538;1564411;1582982;1582997;1583007;1584095;1584109;1588811 Ap2b1;Pex12;Fndc8;Slfn14;Slfn3;Gsta4l1;LOC688910;Slfn1;LOC688871;LOC688857;LOC688477 Bp299 (sub_region) intercross 1642972 SS.LEW-(D10Mco84-D10Mco143)/Mco 1643004 rat Pain2 Pain QTL 2 7 1.0 37382 D7Rat113 35264 D7Rat18 mechanical nociception trait (VT:0002734) self mutilation severity score (CMO:0002145) abnormal pain threshold Pain 1643003 17560719 7 12498167 106942302 1 - by flanking markers 7 10973606 103612887 1 - by flanking markers intercross 1581623 1581640 LA/Humd HA/Humd 7 12328467 106995532 1 - by flanking markers 7 9462246 98011544 1 - by flanking markers 1643006 rat Pain1 Pain QTL 1 2 3.63 0.005 26.0 36145 D2Rat73 36659 D2Rat17 mechanical nociception trait (VT:0002734) self mutilation severity score (CMO:0002145) abnormal pain threshold Pain 1643003 17560719 Pain1_m (maps to syntenic region) 2 45399390 67058673 1 - by flanking markers 2 26101088 48244982 1 - by flanking markers intercross 1581623 1581640 LA/Humd HA/Humd 2 26267995 48676716 1 - by flanking markers 2 26999571 48268661 1 - by flanking markers 2289982 rat Bp303 Blood pressure QTL 303 10 36203 D10Rat27 35513 D10Rat24 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 628510;1643425 11641286;18175179 Bp304 (sub_region);Bp305 (sub_region) 10 74127825 78195122 1 - by flanking markers 10 77091834 79229233 1 - by flanking markers intercross 1641871 SS.MNS-(D10Mco62-D10Mco31)/Jr 10 75983662 78343192 1 - by flanking markers 10 73452992 75632053 1 - by flanking markers 2289983 rat Bp304 Blood pressure QTL 304 10 39500 D10Rat193 38286 D10Rat112 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1643425 18175179 Bp303 (sub_region) 10 74001821 76667915 1 - by flanking markers 10 77219626 77679394 1 - by flanking markers intercross 2289827 SS.MNS-(D10Mco30-D10Mco31)/Jr 10 76109491 76802057 1 - by flanking markers 10 73579541 74119158 1 - by flanking markers 2289985 rat Bp305 Blood pressure QTL 305 10 1642087 D10Mco84 39500 D10Rat193 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 1643425 18175179 Bp303 (sub_region) 10 69542746 74002046 1 - by flanking markers 10 70757255 77219852 1 - by flanking markers intercross 2289819 SS.MNS-(D10Mco62-D10Got99)/Mco 10 69910832 76109716 1 - by flanking markers 10 67502108 73579767 1 - by flanking markers 2290005 rat Mcs24 Mammary carcinoma susceptibility QTL 24 5 69527 D5Uwm29 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1601189 17404222 1305229;1305465 Frmpd1;Fbxo10 Mcs12 (sub_region) 5 72784931 117784931 4 - by one flank marker only 5 70181758 115181758 4 - by one flank marker only 61105 737908 WKY/NHsd WF/NHsd 5 68838385 113838385 4 - by one flank marker only 5 64719390 109719390 4 - by one flank marker only 2290007 rat Mcs23 Mammary carcinoma susceptibility QTL 23 5 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 1601189 17404222 1305465 Fbxo10 Mcs12 (sub_region) 61105 737908 WKY/NHsd WF/NHsd 2290372 rat Gluco33 Glucose level QTL 33 7 2.71 38788 D7Rat72 41252 D7Rat149 35178 D7Rat47 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Experimental Diabetes Mellitus 1626640;2326163 17213368;20530722 7 14768165 36408841 1 - by flanking markers 7 13170547 32454105 1 - by flanking markers intercross 1357181 1357191 CDR/Ygl CDS/Ygl 7 26508887 36346595 2 - by one flank and peak markers 7 20555705 29891047 2 - by one flank and peak markers 2290374 rat Gluco32 Glucose level QTL 32 4 6.27 39194 D4Rat115 35625 D4Rat14 41888 D4Rat282 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) decreased circulating insulin level;increased circulating glucose level Experimental Diabetes Mellitus 1626640;2326163 17213368;20530722 621465 Ica1 Gluco61 (maps to same region) 4 34996009 44024417 1 - by flanking markers 4 34206019 41729771 1 - by flanking markers intercross 1357181 1357191 CDR/Ygl CDS/Ygl 4 35138860 43414792 1 - by flanking markers 4 37177950 44463908 1 - by flanking markers 2290375 rat Gluco34 Glucose level QTL 34 X 2.75 36111 DXRat8 33575 DXMit5 33575 DXMit5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Experimental Diabetes Mellitus 1626640;2326163 17213368;20530722 X 21859080 44765347 1 - by flanking markers X 41386788 62894306 1 - by flanking markers intercross 1357181 1357191 CDR/Ygl CDS/Ygl X 21592623 44468300 1 - by flanking markers X 20990947 41203591 1 - by flanking markers 2290393 rat Uae37 Urinary albumin excretion QTL 37 6 1.0E-4 38608 D6Rat106 36191 D6Rat6 36990 D6Rat12 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria;increased urine protein level Albuminuria 1642911 17953514 6 78348236 132488565 1 - by flanking markers 6 68036028 123455207 1 - by flanking markers intercross 1641831 MWF-Chr 6SHR/Rkb 6 68781170 147991367 2 - by one flank and peak markers 6 65531555 140994061 2 - by one flank and peak markers 2290448 rat Scl54 Serum cholesterol level QTL 54 5 2.93 40330 D5Rat130 33680 D5Mit13 33985 D5Mit11 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 5 36590997 140429983 1 - by flanking markers 5 32701659 138272129 1 - by flanking markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 5 31926122 136640934 1 - by flanking markers 5 31663789 131345958 1 - by flanking markers 2290450 rat Scl57 Serum cholesterol level QTL 57 9 4.15 37604 D9Rat76 41600 D9Rat110 33999 D9Mit5 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 9 40929725 102148004 1 - by flanking markers 9 33496794 94217673 1 - by flanking markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 9 41261034 102531865 1 - by flanking markers 9 36962359 95410867 1 - by flanking markers 2290451 rat Scl58 Serum cholesterol level QTL 58 11 3.48 41734 D11Rat101 34150 D11Mgh5 34130 D11Mgh6 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 SCL37_H (maps to syntenic region) 11 15035502 47637447 1 - by flanking markers 11 12965570 43157054 1 - by flanking markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 11 11367306 44444347 1 - by flanking markers 11 12831046 25121472 2 - by one flank and peak markers 2290452 rat Scl56 Serum cholesterol level QTL 56 3 2.26 35795 D3Rat26 37510 D3Rat100 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 SCL103_H (maps to syntenic region) 3 1 101798901 2 - by one flank and peak markers 3 1 90573782 2 - by one flank and peak markers intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 3 1 95176874 2 - by one flank and peak markers 3 1 91609953 2 - by one flank and peak markers 2290453 rat Scl55 Serum cholesterol level QTL 55 2 2.83 38976 D2Rat124 36466 D2Rat34 40292 D2Rat196 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased cholesterol level Hypercholesterolemia 2290428 17620956 2 45317613 161740132 1 - by flanking markers 2 96755420 141755420 4 - by one flank marker only intercross;intercross 1582184 2290429 SR/JrHsd SS-Tg(ApoC3-CETP)53Opaz 2 26186097 142053534 1 - by flanking markers 2 26917817 136917119 1 - by flanking markers 2292216 rat Bw80 Body weight QTL 80 1 3.23 0.0019 35551 D1Rat117 34971 D1Rat81 36960 D1Rat76 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Body Weight Changes 1626643;2312611 16700878;19697080 Bw85 (maps to same region) 1 240604381 272245383 1 - by flanking markers 1 219629755 250119874 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 233490105 264802994 1 - by flanking markers 1 213533809 243914901 1 - by flanking markers 2292218 rat Kidm35 Kidney mass QTL 35 1 38854 D1Rat168 36960 D1Rat76 35551 D1Rat117 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) decreased kidney weight Body Weight Changes 1626643 16700878 1 224224750 252243871 1 - by flanking markers 1 204621918 230411453 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 217372257 244992610 1 - by flanking markers 1 199368955 224569684 1 - by flanking markers 2292220 rat Bp306 Blood pressure QTL 306 1 3.47 8.7E-4 35311 D1Rat54 34971 D1Rat81 38854 D1Rat168 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1626643 16700878 Bp42 (maps to same region) 1 181904317 272245383 1 - by flanking markers 1 167931220 250119874 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 174905700 264802994 1 - by flanking markers 1 164310393 243914901 1 - by flanking markers 2292222 rat Bp307 Blood pressure QTL 307 1 3.06 0.0014 35311 D1Rat54 35551 D1Rat117 38854 D1Rat168 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 1626643 16700878 1 181904317 240604513 1 - by flanking markers 1 167931220 219629888 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 1 174905700 233490237 1 - by flanking markers 1 164310393 213533942 1 - by flanking markers 2292232 rat Pur16 Proteinuria QTL 16 13 17.2 45025 D13Got8 34833 D13Rat19 41978 D13Arb5 urine total protein amount (VT:0000032) urine protein level (CMO:0000591) increased urine protein level proteinuria 2292230 18064521 71024 Actr3 Pur1 (sub_region) 13 46171139 52282100 1 - by flanking markers 13 37191203 43437366 1 - by flanking markers backcross 61118 61119 BUF/Mna WKY/NCrlCrlj 13 41060057 47227923 1 - by flanking markers 13 36155723 41961389 1 - by flanking markers 2292436 rat Bp310 Blood pressure QTL 310 10 1579093 D10Chm14 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;6480214;7421500 18398331;22124177;23814039 1307333 Abca8a Bp256 (interacts with);Bp257 (interacts with);Bp258 (interacts with);Bp270 (interacts with);Bp279 (interacts with);Bp280 (sub_region);Bp312 (interacts with);Bp315 (interacts with);Bp345 (interacts with);Bp346 (interacts with);Bp347 (interacts with);Bp361 (interacts with);Bp365 (interacts with);Bp369 (interacts with);Bp38 (interacts with) 10 97793396 112200500 4 - by one flank marker only 10 99233734 99588446 1 - by flanking markers intercross 1579903 SS.LEW-(D10Chm10-D10Rat11)/Ayd 10 98079221 112626471 4 - by one flank marker only 10 94759759 107211142 4 - by one flank marker only 2292438 rat Bp311 Blood pressure QTL 311 10 44781 D10Got112 36958 D10Rat9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238 18398331 Bp281 (sub_region) 10 78816241 112200500 4 - by one flank marker only 10 79857808 99588446 1 - by flanking markers intercross 2292386 SS.LEW-(D10Chm155-D10Rat127)/Ayd 10 78970279 112626471 4 - by one flank marker only 10 76246085 107211142 4 - by one flank marker only 2292439 rat Bp309 Blood pressure QTL 309 10 1578839 D10Chm79 1579166 D10Chm3 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;6480214;1559293 18398331;22124177;16286573 2364;620683;1308349;1561541 Cltc;Rps6kb1;Trim37;Prr11 Bp279 (sub_region);Bp308 (interacts with) 10 73626664 75641342 1 - by flanking markers 10 74524802 75428239 1 - by flanking markers intercross 2292387 SS.LEW-(D10Chm224-D10Chm259)/Ayd 10 73727917 74459500 1 - by flanking markers 10 71115217 71966743 1 - by flanking markers 2292440 rat Bp312 Blood pressure QTL 312 10 1578931 D10Chm171 1578994 D10Chm147 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;7421500;8657382 18398331;23814039;23773896 620455;1308645;1561538;1564411;1583007 Slfn4;Slfn2;Slfn14;Slfn3;Slfn1 Bp282 (sub_region);Bp310 (interacts with) 10 69797667 70215618 1 - by flanking markers 10 71032534 71447820 1 - by flanking markers intercross 2292388 SS.LEW-(D10Chm246-D10Chm257)/Ayd 10 70166960 70581793 1 - by flanking markers 10 67750049 68164786 1 - by flanking markers 2292441 rat Bp308 Blood pressure QTL 308 10 1579031 D10Chm4 1578891 D10Chm29 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2292238;6480214 18398331;22124177 708563;735028;1305204;1310306;1588724;1592081 Tspoap1;Ppm1e;Rnf43;Mtmr4;LOC689764;Mpo Bp279 (sub_region);Bp309 (interacts with) 10 30002634 75002634 4 - by one flank marker only 10 31098661 76098661 4 - by one flank marker only intercross 2292390 SS.LEW-(D10Rat194-D10Chm243)/Ayd 10 30099909 75099909 4 - by one flank marker only 10 27606468 72606468 4 - by one flank marker only 2292589 rat Emca10 Estrogen-induced mammary cancer QTL 10 6 0.048 37142 D6Rat80 41266 D6Rat146 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 2292503 18420736 6 1111498 46111498 4 - by one flank marker only 6 1301952 46301952 4 - by one flank marker only 2292564 ACI.COP-(D6Rat80-D6Rat146)/Shul 6 1120393 46120393 4 - by one flank marker only 6 16536140 61536140 4 - by one flank marker only 2292591 rat Esta4 Estrogen-induced thymic atrophy QTL 4 3 39050 D3Rat130 37980 D3Rat114 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) thymus atrophy thymoma 2292503 18420736 3 55227530 160347840 1 - by flanking markers 3 44551252 149496698 1 - by flanking markers 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul 3 48561928 155263151 1 - by flanking markers 3 47233211 147415807 1 - by flanking markers 2292613 rat Ept16 Estrogen-induced pituitary tumorigenesis QTL 16 3 8.3 35451 D3Rat21 39050 D3Rat130 35795 D3Rat26 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept2 (maps to same region) 3 55227748 121789152 1 - by flanking markers 3 44551542 110215186 1 - by flanking markers intercross 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul 3 48562146 115249962 1 - by flanking markers 3 47233430 110362260 1 - by flanking markers 2292615 rat Ept17 Estrogen-induced pituitary tumorigenesis QTL 17 3 6.7 11.0 41830 D3Rat277 34347 D3Mgh16 34186 D3Mgh9 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept6 (maps to same region) 3 11361817 31948244 1 - by flanking markers 3 6373454 22341164 1 - by flanking markers intercross 2292566 ACI.COP-(D3Rat130-D3Rat114)/Shul 3 571136 6000866 2 - by one flank and peak markers 3 6537645 10778823 2 - by one flank and peak markers 2292616 rat Ept15 Estrogen-induced pituitary tumorigenesis QTL 15 6 4.4 1357998 D6Rat150 35683 D6Rat39 37142 D6Rat80 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept1 (maps to same region) 6 8018013 31405507 1 - by flanking markers 6 1 8184962 2 - by one flank and peak markers intercross 2292564 ACI.COP-(D6Rat80-D6Rat146)/Shul 6 8083222 21515439 1 - by flanking markers 6 9843312 20338915 1 - by flanking markers 2292617 rat Ept18 Estrogen-induced pituitary tumorigenesis QTL 18 10 3.9 7.0 35256 D10Rat11 36203 D10Rat27 33690 D10Mit7 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) pituitary gland hyperplasia Pituitary Neoplasms 2292503;7175546 18420736;2292503 Ept9 (maps to same region) 10 74127968 99184058 1 - by flanking markers 10 77092169 100633512 1 - by flanking markers intercross 2292567 ACI.COP-(D10Mgh20-D10Rat4)/Shul 10 75983805 99492217 1 - by flanking markers 10 73453136 96120911 1 - by flanking markers 2293083 rat Iddm25 Insulin dependent diabetes mellitus QTL 25 1 4.18 10951 D1Mit13 36960 D1Rat76 11060 D1Wox23 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 2870;2916 Igf2;Ins2 Iddm10 (maps to same region);Iddm9 (maps to same region) 1 205649453 252243871 1 - by flanking markers 1 186471692 230411453 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 1 198655722 244992610 1 - by flanking markers 1 181829673 224569684 1 - by flanking markers 2293084 rat Iddm26 Insulin dependent diabetes mellitus QTL 26 2 2.9 36091 D2Rat44 36876 D2Rat88 42110 D2Arb16 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106;10043114 1446803;19168599;24920533 1307992 Ptpn22 Iddm3 (maps to same region) 2 208261410 248335979 1 - by flanking markers 2 181710214 222281918 1 - by flanking markers intercross 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 2 188838511 228984665 1 - by flanking markers 2 174930955 213594495 1 - by flanking markers 2293085 rat Iddm29 Insulin dependent diabetes mellitus QTL 29 6 7.66 34098 D6Mgh3 44208 D6Got167 37076 D6Rat1 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 Iddm28 (interacts with);Iddm8 (maps to same region) 6 136507025 156159363 1 - by flanking markers 6 127683728 146651354 1 - by flanking markers 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 6 127286494 147249902 1 - by flanking markers 6 122549046 140286318 1 - by flanking markers 2293086 rat Iddm30 Insulin dependent diabetes mellitus QTL 30 12 3.82 44938 D12Got11 36101 D12Rat15 37272 D12Rat28 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 3447 Ptpn11 12 12281726 33889801 1 - by flanking markers 12 8901318 29369703 1 - by flanking markers intercross 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 12 10175889 31975590 1 - by flanking markers 12 8449490 28302290 1 - by flanking markers 2293087 rat Iddm27 Insulin dependent diabetes mellitus QTL 27 3 2.68 35799 D3Rat24 37980 D3Rat114 36882 D3Rat7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 3 108753156 160347840 1 - by flanking markers 3 96506745 149496698 1 - by flanking markers intercross 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 3 102152812 155263151 1 - by flanking markers 3 97551417 147415807 1 - by flanking markers 2293088 rat Iddm28 Insulin dependent diabetes mellitus QTL 28 6 5.21 36729 D6Rat23 42786 D6Rat169 38494 D6Rat88 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2293011;2299158;2303106 1446803;19168599 Iddm29 (interacts with) 6 75798693 84567798 1 - by flanking markers 6 65393789 74436856 1 - by flanking markers intercross 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 6 66222612 75023308 1 - by flanking markers 6 63040562 71636266 1 - by flanking markers 2293089 rat Iddm31 Insulin dependent diabetes mellitus QTL 31 14 4.7 36536 D14Rat1 33551 D14Mit6 36536 D14Rat1 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140);blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2299158;2303106;2293011 19168599;1446803 14 4830815 19816660 1 - by flanking markers 14 4895894 19800418 1 - by flanking markers intercross 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 14 4833233 19909932 1 - by flanking markers 14 3813074 18274691 1 - by flanking markers 2293140 rat Bp313 Blood pressure QTL 313 1 66611 D1Mco36 2292719 D1Mco101 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2291850;9685377 18324438;25231251 69305 Nr2f2 Bp314 (interacts with);Bp375 (sub_region);Bp376 (sub_region);Bp94 (sub_region) 1 130267716 175267716 4 - by one flank marker only 1 122991895 167991895 4 - by one flank marker only intercross 2292653 SS.LEW-(D1Mco36-D1Mco101)/Mco 1 129208943 174208943 4 - by one flank marker only 1 121833674 166833674 4 - by one flank marker only 2293142 rat Bp314 Blood pressure QTL 314 1 2292749 D1Mco85 35016 D1Rat106 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2291850 18324438 Bp313 (interacts with);Bp94 (sub_region) 1 101282094 146282094 4 - by one flank marker only 1 94471673 139471673 4 - by one flank marker only intercross 2292652 SS.LEW-(D1Mco85-D1Rat49)/Mco 1 100354344 145354344 4 - by one flank marker only 1 92184926 137184926 4 - by one flank marker only 2293341 rat Glom15 Glomerulus QTL 15 13 9.1 36506 D13Rat32 34945 D13Rat51 39262 D13Rat86 kidney glomerulus integrity trait (VT:0010546) kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269) glomerulonephritis glomerulonephritis;nephritis 2293335;2325762 16482158;20488952 71069 Fcgr2a 13 85295639 113387165 1 - by flanking markers 13 78189125 106076220 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 13 80403559 108770687 1 - by flanking markers 13 74862117 101339893 1 - by flanking markers 2293343 rat Glom16 Glomerulus QTL 16 16 7.4 39456 D16Rat88 34894 D16Rat29 41618 D16Rat82 kidney glomerulus integrity trait (VT:0010546) kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269) glomerulonephritis glomerulonephritis;nephritis 2293335;2293336;2325762 16482158;18443593;20488952 2945 Jund 16 1534408 48959444 1 - by flanking markers 16 819225 49333382 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 16 1550187 49247447 1 - by flanking markers 16 832236 46053497 1 - by flanking markers 2293642 rat Bss37 Bone structure and strength QTL 37 5 4.64 1.0E-4 35545 D5Rat28 39478 D5Rat204 42185 D5Arb1 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) abnormal bone structure osteoporosis 2293455 18158281 5 129313212 160966475 1 - by flanking markers 5 126963761 157597184 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 5 125455818 157225114 1 - by flanking markers 5 120740824 151018848 1 - by flanking markers 2293644 rat Bmd29 Bone mineral density QTL 29 7 5.4 1.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 7 78253693 123378833 1 - by flanking markers 7 74658964 120536775 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293646 rat Bss25 Bone structure and strength QTL 25 10 10.96 1.0E-4 36283 D10Rat15 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 10 72743019 112200500 5 - by peak with adj size 10 74167134 110718848 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 73008136 112626471 5 - by peak with adj size 10 69738412 107211142 5 - by peak with adj size 2293648 rat Bmd31 Bone mineral density QTL 31 17 4.5 1.0E-4 38150 D17Rat80 34827 D17Rat12 34827 D17Rat12 femur size trait (VT:1000369) femoral neck cortical cross-sectional area (CMO:0001702) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 17 6945553 29605354 1 - by flanking markers 17 10044240 33277509 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 17 4716067 27691136 1 - by flanking markers 17 4354487 27028127 1 - by flanking markers 2293650 rat Bss31 Bone structure and strength QTL 31 6 5.05 1.0E-4 35653 D6Rat42 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 6 8559248 53559248 5 - by peak with adj size 6 1 42401411 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 43665660 5 - by peak with adj size 6 1 42487980 5 - by peak with adj size 2293652 rat Bmd22 Bone mineral density QTL 22 10 4.9 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293654 rat Bss30 Bone structure and strength QTL 30 1 32.65 1.0E-4 36460 D1Rat69 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293655 rat Bss36 Bone structure and strength QTL 36 1 10.66 1.0E-4 37902 D1Rat169 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) abnormal bone structure osteoporosis 2293455 18158281 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2293656 rat Bss28 Bone structure and strength QTL 28 6 6.79 1.0E-4 35653 D6Rat42 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure osteoporosis 2293455 18158281 6 8559248 53559248 5 - by peak with adj size 6 1 42401411 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 43665660 5 - by peak with adj size 6 1 42487980 5 - by peak with adj size 2293658 rat Bmd23 Bone mineral density QTL 23 18 7.3 1.0E-4 38146 D18Rat50 34975 D18Rat13 34975 D18Rat13 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 18 52220612 67678102 1 - by flanking markers 18 53847682 66720186 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 53033494 68524999 1 - by flanking markers 18 51464733 63636873 1 - by flanking markers 2293659 rat Bmd35 Bone mineral density QTL 35 4 4.5 1.0E-4 37850 D4Rat104 36562 D4Rat72 36562 D4Rat72 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) increased bone mineral density osteoporosis 2293456 18282130 4 201377951 247013637 1 - by flanking markers 4 140454608 186104310 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 4 136908430 182878540 1 - by flanking markers 4 137755016 181392681 1 - by flanking markers 2293661 rat Bss50 Bone structure and strength QTL 50 18 4.64 3.0E-4 37578 D18Rat65 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 18 1 37966407 5 - by peak with adj size 18 1 34745192 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 1 38195967 5 - by peak with adj size 18 1 34291613 5 - by peak with adj size 2293663 rat Bss33 Bone structure and strength QTL 33 10 9.34 1.0E-4 36283 D10Rat15 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 10 72743019 112200500 5 - by peak with adj size 10 74167134 110718848 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 73008136 112626471 5 - by peak with adj size 10 69738412 107211142 5 - by peak with adj size 2293664 rat Bmd28 Bone mineral density QTL 28 17 5.1 1.0E-4 38150 D17Rat80 34827 D17Rat12 34827 D17Rat12 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 17 6945553 29605354 1 - by flanking markers 17 10044240 33277509 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 17 4716067 27691136 1 - by flanking markers 17 4354487 27028127 1 - by flanking markers 2293666 rat Bmd38 Bone mineral density QTL 38 5 4.4 40562 D5Rat187 35132 D5Rat3 femur size trait (VT:1000369) femoral neck cortical cross-sectional area (CMO:0001702) increased bone mineral density osteoporosis 2293456 18282130 5 13440622 58440622 4 - by one flank marker only 5 8464827 40137122 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 5 8632285 53632285 4 - by one flank marker only 5 8948228 53948228 4 - by one flank marker only 2293667 rat Bss42 Bone structure and strength QTL 42 7 7.25 1.0E-4 35919 D7Rat23 lumbar vertebra size trait (VT:0010518) lumbar vertebra cross-sectional area (CMO:0001689) abnormal bone strength osteoporosis 2293455 18158281 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293669 rat Bmd33 Bone mineral density QTL 33 10 4.5 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur strength trait (VT:0010010) femoral neck polar moment of inertia (CMO:0001670) increased bone mineral density osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293671 rat Bss44 Bone structure and strength QTL 44 2 10.97 1.0E-4 39874 D2Rat198 37330 D2Rat181 40462 D2Rat280 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) abnormal bone strength osteoporosis 2293455 18158281 2 62186976 173967037 1 - by flanking markers 2 42874025 153832507 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 43141290 154583160 1 - by flanking markers 2 43162366 148478373 1 - by flanking markers 2293673 rat Bss27 Bone structure and strength QTL 27 1 18.63 1.0E-4 36460 D1Rat69 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293674 rat Bss39 Bone structure and strength QTL 39 1 7.1 1.0E-4 37902 D1Rat169 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) abnormal bone structure osteoporosis 2293455 18158281 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2293676 rat Bmd19 Bone mineral density QTL 19 2 10.7 1.0E-4 39874 D2Rat198 40462 D2Rat280 40462 D2Rat280 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 2 62186976 133866167 1 - by flanking markers 2 42874025 87874025 4 - by one flank marker only intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 43141290 114164944 1 - by flanking markers 2 43162366 111362592 1 - by flanking markers 2293677 rat Bss41 Bone structure and strength QTL 41 1 9.38 1.0E-4 36460 D1Rat69 lumbar vertebra size trait (VT:0010518) lumbar vertebra cross-sectional area (CMO:0001689) abnormal bone strength osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293678 rat Bss24 Bone structure and strength QTL 24 7 6.71 1.0E-4 35919 D7Rat23 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293679 rat Bmd30 Bone mineral density QTL 30 10 3.5 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293680 rat Bss40 Bone structure and strength QTL 40 10 5.66 1.0E-4 33630 D10Mit17 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) abnormal bone structure osteoporosis 2293455 18158281 10 1 35358590 5 - by peak with adj size 10 1 35460104 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 1 35538813 5 - by peak with adj size 10 1 35225947 5 - by peak with adj size 2293682 rat Bmd24 Bone mineral density QTL 24 2 8.9 1.0E-4 39874 D2Rat198 40462 D2Rat280 40462 D2Rat280 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 2 62186976 133866167 1 - by flanking markers 2 42874025 87874025 4 - by one flank marker only intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 43141290 114164944 1 - by flanking markers 2 43162366 111362592 1 - by flanking markers 2293684 rat Bmd26 Bone mineral density QTL 26 12 4.4 2.0E-4 40408 D12Rat91 39060 D12Rat30 40408 D12Rat91 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 12 19953929 40290100 1 - by flanking markers 12 16387455 34112949 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 12 17960865 38409001 1 - by flanking markers 12 15872653 32974238 1 - by flanking markers 2293685 rat Bmd21 Bone mineral density QTL 21 7 4.2 3.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 7 78253693 123378833 1 - by flanking markers 7 74658964 120536775 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293686 rat Bmd36 Bone mineral density QTL 36 15 7.4 1.0E-4 40084 D15Rat117 40882 D15Rat97 40084 D15Rat117 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) increased bone mineral density osteoporosis 2293456 18282130 15 43570947 82573380 1 - by flanking markers 15 38542355 78048493 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 39749557 79033707 1 - by flanking markers 15 33611058 71477291 1 - by flanking markers 2293687 rat Bss26 Bone structure and strength QTL 26 13 4.6 1.0E-4 39262 D13Rat86 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 13 75695127 118718031 5 - by peak with adj size 13 68910877 111154910 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 13 71230858 114033958 5 - by peak with adj size 13 65103704 106807694 5 - by peak with adj size 2293688 rat Bss29 Bone structure and strength QTL 29 15 5.31 1.0E-4 40084 D15Rat117 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) abnormal bone structure osteoporosis 2293455 18158281 15 21071031 66071031 5 - by peak with adj size 15 16042557 61042557 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 17249641 62249641 5 - by peak with adj size 15 11111142 56111142 5 - by peak with adj size 2293689 rat Bss47 Bone structure and strength QTL 47 1 7.25 1.0E-4 36460 D1Rat69 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293690 rat Bss45 Bone structure and strength QTL 45 16 5.13 1.0E-4 40234 D16Rat60 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) abnormal bone strength osteoporosis 2293455 18158281 16 41174014 86174014 5 - by peak with adj size 16 41581459 86581459 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 16 41512710 86512710 5 - by peak with adj size 16 37752156 82752156 5 - by peak with adj size 2293691 rat Bmd37 Bone mineral density QTL 37 15 6.6 1.0E-4 40084 D15Rat117 40882 D15Rat97 40882 D15Rat97 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) increased bone mineral density osteoporosis 2293456 18282130 15 43570947 82573380 1 - by flanking markers 15 38542355 78048493 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 39749557 79033707 1 - by flanking markers 15 33611058 71477291 1 - by flanking markers 2293693 rat Bss22 Bone structure and strength QTL 22 1 33.52 1.0E-4 36460 D1Rat69 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2293694 rat Bss38 Bone structure and strength QTL 38 1 7.05 1.0E-4 37902 D1Rat169 femur strength trait (VT:0010010) femur stiffness (CMO:0001674) abnormal bone structure osteoporosis 2293455 18158281 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2293696 rat Bmd32 Bone mineral density QTL 32 7 5.1 1.0E-4 35919 D7Rat23 37802 D7Rat78 35919 D7Rat23 femur strength trait (VT:0010010) femoral neck polar moment of inertia (CMO:0001670) increased bone mineral density osteoporosis 2293456 18282130 7 78253693 123378833 1 - by flanking markers 7 74658964 120536775 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293697 rat Bmd39 Bone mineral density QTL 39 8 38742 D8Rat111 35018 D8Rat15 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) increased bone mineral density osteoporosis 2293456 18282130 8 56813094 105836747 1 - by flanking markers 8 57109012 103548876 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 8 58230766 106394378 1 - by flanking markers 8 54043744 98968765 1 - by flanking markers 2293698 rat Bss43 Bone structure and strength QTL 43 10 5.33 1.0E-4 37900 D10Rat124 lumbar vertebra size trait (VT:0010518) lumbar vertebra cross-sectional area (CMO:0001689) abnormal bone strength osteoporosis 2293455 18158281 10 61889555 106889555 5 - by peak with adj size 10 62984501 107984501 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 62096293 107096293 5 - by peak with adj size 10 59209888 104209888 5 - by peak with adj size 2293699 rat Bss49 Bone structure and strength QTL 49 12 5.61 1.0E-4 39060 D12Rat30 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 12 17789999 54450796 5 - by peak with adj size 12 11612769 46782294 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 12 15908900 52716770 5 - by peak with adj size 12 10474137 46669029 5 - by peak with adj size 2293700 rat Bmd27 Bone mineral density QTL 27 1 6.6 1.0E-4 37902 D1Rat169 36874 D1Rat82 37902 D1Rat169 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 1 251652807 272078414 1 - by flanking markers 1 229876870 249951685 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 244401175 264636028 1 - by flanking markers 1 224054293 243747962 1 - by flanking markers 2293701 rat Bmd34 Bone mineral density QTL 34 1 8.3 1.0E-4 37902 D1Rat169 36874 D1Rat82 37902 D1Rat169 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) increased bone mineral density osteoporosis 2293456 18282130 1 251652807 272078414 1 - by flanking markers 1 229876870 249951685 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 244401175 264636028 1 - by flanking markers 1 224054293 243747962 1 - by flanking markers 2293702 rat Bss34 Bone structure and strength QTL 34 13 4.61 1.0E-4 39262 D13Rat86 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 13 75695127 118718031 5 - by peak with adj size 13 68910877 111154910 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 13 71230858 114033958 5 - by peak with adj size 13 65103704 106807694 5 - by peak with adj size 2293703 rat Bss48 Bone structure and strength QTL 48 7 16.05 1.0E-4 37802 D7Rat78 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) abnormal bone strength osteoporosis 2293455 18158281 7 100878730 143501887 5 - by peak with adj size 7 98036672 143002779 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2293704 rat Bss35 Bone structure and strength QTL 35 18 4.59 2.0E-4 38146 D18Rat50 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 18 29720732 74720732 5 - by peak with adj size 18 31347802 76347802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 30533614 75533614 5 - by peak with adj size 18 28964853 73964853 5 - by peak with adj size 2293705 rat Bmd25 Bone mineral density QTL 25 10 7.1 1.0E-4 40302 D10Rat162 37900 D10Rat124 40302 D10Rat162 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density;increased compact bone thickness osteoporosis 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 2293706 rat Bmd20 Bone mineral density QTL 20 6 4.3 2.0E-4 35963 D6Rat46 35653 D6Rat42 35963 D6Rat46 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2293456 18282130 6 23080221 31059317 1 - by flanking markers 6 13286615 19901481 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 13122958 21165729 1 - by flanking markers 6 5074497 19988050 1 - by flanking markers 2293707 rat Bss32 Bone structure and strength QTL 32 7 7.64 1.0E-4 35919 D7Rat23 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) abnormal bone structure osteoporosis 2293455 18158281 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2293708 rat Bss46 Bone structure and strength QTL 46 18 8.8 1.0E-4 37578 D18Rat65 34975 D18Rat13 38146 D18Rat50 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) abnormal bone strength osteoporosis 2293455 18158281 18 15466312 67678102 1 - by flanking markers 18 12245097 66720186 1 - by flanking markers intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 15695872 68524999 1 - by flanking markers 18 11791518 63636873 1 - by flanking markers 2293709 rat Bss23 Bone structure and strength QTL 23 6 5.18 1.0E-4 35653 D6Rat42 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) abnormal bone structure osteoporosis 2293455 18158281 6 8559248 53559248 5 - by peak with adj size 6 1 42401411 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 43665660 5 - by peak with adj size 6 1 42487980 5 - by peak with adj size 2293833 rat Kiddil8 Kidney dilation QTL 8 2 2.9 35849 D2Rat62 36241 D2Rat72 38554 D2Rat112 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) hydronephrosis 2293631 18523158 Kiddil7 (maps to same region) 2 254867191 283538297 1 - by flanking markers 2 228663949 256217383 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 2 236318496 264899009 1 - by flanking markers 2 219753301 247136170 1 - by flanking markers 2293835 rat Kiddil5 Kidney dilation QTL 5 2 3.8 37018 D2Rat14 36213 D2Rat40 41400 D2Rat216 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hematuria;hydronephrosis Hematuria;hydronephrosis 2293631 18523158 2071 Agtr1b 2 61825950 189197988 1 - by flanking markers 2 118154358 163154358 4 - by one flank marker only backcross 631594 1357985 BN/Rj LOU/Ins 2 42776916 169852800 1 - by flanking markers 2 42804607 157142209 1 - by flanking markers 2293837 rat Kiddil1 Kidney dilation QTL 1 6 3.7 33993 D6Mit2 38290 D6Rat76 38268 D6Rat102 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 Kiddil3 (maps to same region) 6 94275468 117085239 1 - by flanking markers 6 84287190 108790535 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 84763275 108464097 1 - by flanking markers 6 81132889 104393926 1 - by flanking markers 2293839 rat Kiddil2 Kidney dilation QTL 2 6 4.8 35134 D6Rat41 33993 D6Mit2 42778 D6Rat171 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 2859;1311209 Id2;Emilin1 Kiddil4 (maps to same region) 6 31931908 94275614 1 - by flanking markers 6 20798926 84287337 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 22042854 84763421 1 - by flanking markers 6 20866422 81133036 1 - by flanking markers 2293840 rat Kiddil9 Kidney dilation QTL 9 4 2.9 35278 D4Rat46 37592 D4Rat141 36898 D4Rat80 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 4 185640598 210231755 1 - by flanking markers 4 122550935 151158853 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 4 120400597 146942261 1 - by flanking markers 4 120926564 148090731 1 - by flanking markers 2293841 rat Kiddil4 Kidney dilation QTL 4 6 4.4 35134 D6Rat41 33993 D6Mit2 42778 D6Rat171 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 2859;1311209 Id2;Emilin1 Kiddil2 (maps to same region) 6 31931908 94275614 1 - by flanking markers 6 20798926 84287337 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 22042854 84763421 1 - by flanking markers 6 20866422 81133036 1 - by flanking markers 2293842 rat Kiddil3 Kidney dilation QTL 3 6 4.3 33993 D6Mit2 38290 D6Rat76 38268 D6Rat102 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 Kiddil1 (maps to same region) 6 94275468 117085239 1 - by flanking markers 6 84287190 108790535 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 6 84763275 108464097 1 - by flanking markers 6 81132889 104393926 1 - by flanking markers 2293843 rat Kiddil6 Kidney dilation QTL 6 2 3.1 37018 D2Rat14 37672 D2Rat87 41400 D2Rat216 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hydronephrosis hydronephrosis 2293631 18523158 2071 Agtr1b 2 61825950 215123776 1 - by flanking markers 2 144377723 189377723 4 - by one flank marker only backcross 631594 1357985 BN/Rj LOU/Ins 2 42776916 195645082 1 - by flanking markers 2 42804607 182042367 1 - by flanking markers 2293844 rat Kiddil7 Kidney dilation QTL 7 2 3.5 35849 D2Rat62 36241 D2Rat72 38554 D2Rat112 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) abnormal kidney pelvis morphology;hematuria;hydronephrosis Hematuria;hydronephrosis 2293631 18523158 Kiddil8 (maps to same region) 2 254867191 283538297 1 - by flanking markers 2 228663949 256217383 1 - by flanking markers backcross 631594 1357985 BN/Rj LOU/Ins 2 236318496 264899009 1 - by flanking markers 2 219753301 247136170 1 - by flanking markers 2298475 rat Eau6 Experimental allergic uveoretinitis QTL 6 7 0.0029 10431 D7Wox18 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation Experimental Autoimmune Uveitis 2296064 18453595 2454;2896;3735;71040;621312;628675 Cyp11b2;Il2rb;Sox10;Txn2;St13;Mapk15 Niddm14 (maps to same region) 7 93629275 138629275 5 - by peak with adj size 7 90478161 135478161 5 - by peak with adj size intercross 61109 1298093 F344/NHsd LEW/NHsd 7 93726906 138726906 5 - by peak with adj size 7 84257275 129257275 5 - by peak with adj size 2298477 rat Eau4 Experimental allergic uveoretinitis QTL 4 3 0.0011 10502 D3Mgh10 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 2031;2200;2327;2810;2954;3267;61965;61998;68326;620228;620811;621320;628786;1303179 Ada;Bcl2l1;Cebpb;Hnf4a;Kcnb1;Pck1;Ptpn1;Ywhab;Vapb;Slco4a1;Slc12a5;Mmp9;Slc13a3;Bpi recessive Iddm13 (maps to same region) 3 152328805 183740530 5 - by peak with adj size 3 139485124 171063335 5 - by peak with adj size intercross 61109 1298093 F344/NHsd LEW/NHsd 3 146232777 177699992 5 - by peak with adj size 3 137398739 169034231 5 - by peak with adj size 2298478 rat Eau8 Experimental allergic uveoretinitis QTL 8 19 0.0163 10418 D19Mit6 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation Experimental Autoimmune Uveitis 2296064 18453595 2406;2444;2503;2825;2835;620573;620981;631410;1304832;1359653;1591020 Bcar1;Ctrb1;Nqo1;Hp;Hsd11b2;Cyba;Calb2;Vac14;Aars1;Kars1;Adat1 Cia14 (maps to same region) 19 32215458 72914587 5 - by peak with adj size 19 19112825 59218465 5 - by peak with adj size intercross 61109 1298093 F344/NHsd LEW/NHsd 19 21407787 62275575 5 - by peak with adj size 19 17154433 57337602 5 - by peak with adj size 2298479 rat Eau5 Experimental allergic uveoretinitis QTL 5 2 0.0021 34461 D2Mgh12 34401 D2Mgh22 67315 D2Arb24 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 2263;2591;3810;69228;69238;70498;70967;620047;620241 Camk2d;Fabp2;Tacr3;Cxxc4;Prss12;Nfkb1;Casp6;Il2;Lef1 additive Cia10 (maps to same region) 2 235592715 272824647 1 - by flanking markers 2 210636008 247306073 1 - by flanking markers intercross 61109 1298093 F344/NHsd LEW/NHsd 2 217498545 254132424 1 - by flanking markers 2 202446871 237938339 1 - by flanking markers 2298480 rat Eau7 Experimental allergic uveoretinitis QTL 7 10 0.0049 34318 D10Mgh10 61279 D10Arb3 33565 D10Mit9 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 2425;2592;2897;2898;2900;2907;2920;3702;621149;628704;628847;1564790 Csf1r;Fabp6;Il3;Il4;Il5;Il9r;Irf1;Slc22a5;Slc22a4;Il12b;Mapk9;Scgb3a2 additive Eae3 (maps to same region);Pia15 (maps to same region) 10 35428387 35954931 1 - by flanking markers 10 35713561 36254741 1 - by flanking markers intercross 61109 1298093 F344/NHsd LEW/NHsd 10 35669573 36185929 1 - by flanking markers 10 27957626 34490668 2 - by one flank and peak markers 2298481 rat Eau9 Experimental allergic uveoretinitis QTL 9 10 0.0169 41939 D10Arb27 34274 D10Mgh5 41298 D10Rat153 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) abnormal uvea morphology;decreased susceptibility to experimental autoimmune uveoretinitis;eye inflammation;increased susceptibility to experimental autoimmune uveoretinitis Experimental Autoimmune Uveitis 2296064 18453595 3185;3644;3645;3647;3830;69069;620441;629472 Nos2;Ccl11;Ccl2;Ccl3;Hnf1b;Ccl5;Ccl4;Cdk5r1 additive Eae18 (maps to same region) 10 67971352 85302564 1 - by flanking markers 10 69160380 86317054 1 - by flanking markers intercross 61109 1298093 F344/NHsd LEW/NHsd 10 68305037 85514044 1 - by flanking markers 10 65927233 82565079 1 - by flanking markers 2298495 rat Eae23 Experimental allergic encephalomyelitis QTL 23 10 16.93 1631253 D10Wox42 41254 D10Rat159 42370 D10Rat238 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis duration (CMO:0001424) CNS inflammation;weight loss Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2293859 16624898 70906;619913;631374;1308200;1309457 Aipl1;Tekt1;Slc13a5;Pitpnm3;Med31 additive Eae18 (sub_region);Eae18a (sub_region);Eae3 (sub_region) 10 56926196 64030303 1 - by flanking markers 10 57438568 63167167 1 - by flanking markers intercross 2298494 Kini:DA,PVG-G10 10 57180653 63976874 1 - by flanking markers 10 55273696 60677262 1 - by flanking markers 2298542 rat Neuinf11 Neuroinflammation QTL 11 3 3.9 36657 D3Rat58 35443 D3Rat30 10260 D3Rat52 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 3 15478680 86480754 1 - by flanking markers 3 10829503 75308165 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 3 10119318 79772001 1 - by flanking markers 3 15005422 76927699 1 - by flanking markers 2298544 rat Neuinf9 Neuroinflammation QTL 9 10 4.6 44672 D10Got12 37450 D10Rat133 36496 D10Rat37 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 10 4695640 64823355 1 - by flanking markers 10 5761138 65668639 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 10 5877536 64401490 2 - by one flank and peak markers 10 5801990 62146030 2 - by one flank and peak markers 2298545 rat Neuinf8 Neuroinflammation QTL 8 1 4.6 37960 D1Rat196 35667 D1Rat107 35268 D1Rat34 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 1 59282428 167925457 1 - by flanking markers 1 55083934 154002647 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 1 58354072 161711996 1 - by flanking markers 1 57336763 151090257 1 - by flanking markers 2298546 rat Neuinf4 Neuroinflammation QTL 4 1 5.1 38230 D1Rat234 37658 D1Rat247 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 1 1 30115455 5 - by peak with adj size 1 1 41225199 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 1 1 28468970 5 - by peak with adj size 1 1 28736750 5 - by peak with adj size 2298547 rat Neuinf5 Neuroinflammation QTL 5 7 3.7 37382 D7Rat113 39094 D7Rat58 41516 D7Rat148 nervous system integrity trait (VT:0010566) spinal cord Cd74 protein level (CMO:0002131) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 7 12498167 67382413 1 - by flanking markers 7 10973606 87034412 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 7 12328467 67193263 1 - by flanking markers 7 9462246 58265113 1 - by flanking markers 2298548 rat Neuinf7 Neuroinflammation QTL 7 10 3.4 37450 D10Rat133 35627 D10Rat12 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 10 64823161 112200500 2 - by one flank and peak markers 10 65668446 110718848 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 10 75544754 112626471 5 - by peak with adj size 10 72224939 107211142 5 - by peak with adj size 2298549 rat Neuinf12 Neuroinflammation QTL 12 15 3.5 37794 D15Rat48 38578 D15Rat73 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 15 1 65959514 2 - by one flank and peak markers 15 1 61161186 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 15 1 62301382 2 - by one flank and peak markers 15 1 55302115 2 - by one flank and peak markers 2298550 rat Neuinf6 Neuroinflammation QTL 6 7 3.3 36715 D7Rat30 37382 D7Rat113 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 7 1 34212335 2 - by one flank and peak markers 7 1 30339432 2 - by one flank and peak markers 737945 2312352 BN/Han LEW.1N 7 1 34147172 2 - by one flank and peak markers 7 1 27829089 2 - by one flank and peak markers 2298551 rat Neuinf10 Neuroinflammation QTL 10 11 3.7 35933 D11Rat12 37942 D11Rat46 41240 D11Rat83 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) abnormal level of surface class II molecules autoimmune disease of the nervous system 2298540;2311085 19525015 additive 11 35759925 85534312 1 - by flanking markers 11 31988113 81091531 1 - by flanking markers 737945 2312352 BN/Han LEW.1N 11 32155520 82443118 1 - by flanking markers 11 31239134 78851519 1 - by flanking markers 2299160 rat Iddm35 Insulin dependent diabetes mellitus QTL 35 18 2.79 39582 D18Rat109 42052 D18Arb6 40002 D18Rat116 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 18 4393832 61757227 1 - by flanking markers 18 4320091 76880933 2 - by one flank and peak markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 18 4407513 62570466 1 - by flanking markers 18 4207941 60377792 1 - by flanking markers 2299161 rat Iddm33 Insulin dependent diabetes mellitus QTL 33 2 2.98 35599 D2Rat82 34858 D2Rat69 36876 D2Rat88 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 1307992 Ptpn22 2 239538172 272813962 1 - by flanking markers 2 214633709 247295816 1 - by flanking markers 2293012 ACI.BBDP-(RT1u)(Gimap5)/Sunn 2 221488355 254121739 1 - by flanking markers 2 206312063 220876787 2 - by one flank and peak markers 2299162 rat Iddm32 Insulin dependent diabetes mellitus QTL 32 2 2.36 36693 D2Rat75 34005 D2Mit8 39090 D2Rat180 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 620047;1307384;1359309 Il2;Il21;Adad1 2 100298393 169047413 1 - by flanking markers 2 79796790 148790758 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 2 80631950 149614623 1 - by flanking markers 2 78665616 143657569 1 - by flanking markers 2299163 rat Iddm34 Insulin dependent diabetes mellitus QTL 34 7 2.71 36015 D7Rat21 35034 D7Rat2 1633865 D7Wox48 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) increased circulating glucose level type 1 diabetes mellitus 2303106;2299158 19168599 7 100609080 143501887 2 - by one flank and peak markers 7 96517746 137757704 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 7 100028953 145729302 2 - by one flank and peak markers 7 91281130 135012528 2 - by one flank and peak markers 2300002 rat Iddm36 Insulin dependent diabetes mellitus QTL 36 17 1.98 35354 D17Rat6 37402 D17Rat78 36185 D17Rat11 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level type 1 diabetes mellitus 2299158;2303106 19168599 17 12655344 44408022 1 - by flanking markers 17 16053169 47628829 1 - by flanking markers 2293012 2306717 ACI.BBDP-(RT1u)(Gimap5)/Sunn BBDP/WorSunn 17 10529709 42542027 1 - by flanking markers 17 9991286 40540197 1 - by flanking markers 2300157 rat Bmd66 Bone mineral density QTL 66 18 13.1 1.0E-4 38146 D18Rat50 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 18 29720732 74720732 5 - by peak with adj size 18 31347802 76347802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 30533614 75533614 5 - by peak with adj size 18 28964853 73964853 5 - by peak with adj size 2300159 rat Bmd61 Bone mineral density QTL 61 14 5.3 1.0E-4 39204 D14Rat54 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 14 1 27589631 5 - by peak with adj size 14 1 27616586 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 14 1 27597761 5 - by peak with adj size 14 1 26541967 5 - by peak with adj size 2300161 rat Bmd43 Bone mineral density QTL 43 1 8.4 1.0E-4 36460 D1Rat69 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2300163 rat Bmd64 Bone mineral density QTL 64 16 5.3 1.0E-4 40234 D16Rat60 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 16 41174014 86174014 5 - by peak with adj size 16 41581459 86581459 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 16 41512710 86512710 5 - by peak with adj size 16 37752156 82752156 5 - by peak with adj size 2300164 rat Bmd44 Bone mineral density QTL 44 1 5.4 1.0E-4 39532 D1Rat261 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd45 (interacts with) 1 59474685 104474685 5 - by peak with adj size 1 56601368 101601368 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 58209327 103209327 5 - by peak with adj size 1 56949932 101949932 5 - by peak with adj size 2300165 rat Bmd49 Bone mineral density QTL 49 2 4.8 1.0E-4 40462 D2Rat280 lumbar vertebra mineral mass (VT:0010511) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 2 111366095 156366095 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 2300167 rat Bmd63 Bone mineral density QTL 63 15 5.9 1.0E-4 40084 D15Rat117 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 15 21071031 66071031 5 - by peak with adj size 15 16042557 61042557 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 17249641 62249641 5 - by peak with adj size 15 11111142 56111142 5 - by peak with adj size 2300168 rat Bmd47 Bone mineral density QTL 47 2 6.6 1.0E-4 39874 D2Rat198 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 2 39687057 84687057 5 - by peak with adj size 2 20374107 65374107 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 20641371 65641371 5 - by peak with adj size 2 20662448 65662448 5 - by peak with adj size 2300170 rat Bmd45 Bone mineral density QTL 45 2 12.1 1.0E-4 40462 D2Rat280 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd41 (interacts with);Bmd44 (interacts with);Bmd59 (interacts with) 2 111366095 156366095 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 2300171 rat Bmd58 Bone mineral density QTL 58 10 4.9 1.0E-4 40302 D10Rat162 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 10 28547602 73547602 5 - by peak with adj size 10 28599269 73599269 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 28789280 73789280 5 - by peak with adj size 10 26944628 71944628 5 - by peak with adj size 2300172 rat Bmd57 Bone mineral density QTL 57 10 9.8 1.0E-4 36283 D10Rat15 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 10 72743019 112200500 5 - by peak with adj size 10 74167134 110718848 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 10 73008136 112626471 5 - by peak with adj size 10 69738412 107211142 5 - by peak with adj size 2300173 rat Bmd62 Bone mineral density QTL 62 15 12.8 1.0E-4 40084 D15Rat117 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105;2316850 18707222;19153792;19841953 1308288;1311147;1312015;1359146;1592114 Lcp1;Mdp1;Xpo4;Pdhb;Esd Bmd67 (interacts with) 15 21071031 66071031 5 - by peak with adj size 15 16042557 61042557 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 15 17249641 62249641 5 - by peak with adj size 15 11111142 56111142 5 - by peak with adj size 2300174 rat Bmd42 Bone mineral density QTL 42 1 8.4 1.0E-4 36460 D1Rat69 lumbar vertebra mineral mass (VT:0010511) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2300175 rat Bmd40 Bone mineral density QTL 40 1 15.4 1.0E-4 37902 D1Rat169 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 2300176 rat Bmd51 Bone mineral density QTL 51 6 11.7 1.0E-4 35963 D6Rat46 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109 18707222 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 2300177 rat Bmd65 Bone mineral density QTL 65 18 19.7 1.0E-4 38146 D18Rat50 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 18 29720732 74720732 5 - by peak with adj size 18 31347802 76347802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 30533614 75533614 5 - by peak with adj size 18 28964853 73964853 5 - by peak with adj size 2300178 rat Bmd54 Bone mineral density QTL 54 7 5.3 1.0E-4 35919 D7Rat23 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 7 55753806 100753806 5 - by peak with adj size 7 52159077 97159077 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 7 55495689 100495689 5 - by peak with adj size 7 47651439 92651439 5 - by peak with adj size 2300179 rat Bmd50 Bone mineral density QTL 50 4 5.9 1.0E-4 38262 D4Rat103 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd60 (interacts with) 4 126636060 171636060 5 - by peak with adj size 4 60200806 105200806 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 4 61975371 106975371 5 - by peak with adj size 4 60928534 105928534 5 - by peak with adj size 2300180 rat Bmd67 Bone mineral density QTL 67 18 4.8 1.0E-4 37578 D18Rat65 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd62 (interacts with) 18 1 37966407 5 - by peak with adj size 18 1 34745192 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 18 1 38195967 5 - by peak with adj size 18 1 34291613 5 - by peak with adj size 2300181 rat Bmd55 Bone mineral density QTL 55 8 5.7 1.0E-4 35018 D8Rat15 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 8 83336673 128336673 5 - by peak with adj size 8 81048802 126048802 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 8 83894304 128894304 5 - by peak with adj size 8 76468691 121468691 5 - by peak with adj size 2300182 rat Bmd56 Bone mineral density QTL 56 8 5.4 36327 D8Rat2 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd53 (interacts with) 8 103904881 132457389 5 - by peak with adj size 8 100915338 129041809 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 8 104682575 133307652 5 - by peak with adj size 8 95718998 123900184 5 - by peak with adj size 2300183 rat Bmd60 Bone mineral density QTL 60 14 5.7 1.0E-4 39204 D14Rat54 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd50 (interacts with);Bmd68 (interacts with) 14 1 27589631 5 - by peak with adj size 14 1 27616586 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 14 1 27597761 5 - by peak with adj size 14 1 26541967 5 - by peak with adj size 2300184 rat Bmd53 Bone mineral density QTL 53 7 5.4 1.0E-4 37802 D7Rat78 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd56 (interacts with) 7 100878730 143501887 5 - by peak with adj size 7 98036672 143002779 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2300185 rat Bmd46 Bone mineral density QTL 46 2 8.4 1.0E-4 40462 D2Rat280 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 2 111366095 156366095 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 2300186 rat Bmd59 Bone mineral density QTL 59 12 7.1 1.0E-4 39060 D12Rat30 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd45 (interacts with) 12 17789999 54450796 5 - by peak with adj size 12 11612769 46782294 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 12 15908900 52716770 5 - by peak with adj size 12 10474137 46669029 5 - by peak with adj size 2300187 rat Bmd41 Bone mineral density QTL 41 1 8.9 1.0E-4 36460 D1Rat69 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd45 (interacts with) 1 196094744 241094744 5 - by peak with adj size 1 176612333 221612333 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 1 189170900 234170900 5 - by peak with adj size 1 171629477 216629477 5 - by peak with adj size 2300188 rat Bmd68 Bone mineral density QTL 68 20 6.4 1.0E-4 37792 D20Rat29 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109;2303105 18707222;19153792 Bmd60 (interacts with) 20 28247365 57791882 5 - by peak with adj size 20 25555772 55268282 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 20 26608843 56205956 5 - by peak with adj size 20 25106722 54435887 5 - by peak with adj size 2300189 rat Bmd48 Bone mineral density QTL 48 2 5.8 1.0E-4 36031 D2Rat54 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 2 212470173 257470173 5 - by peak with adj size 2 187512114 232512114 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 2 194378622 239378622 5 - by peak with adj size 2 179335906 224335906 5 - by peak with adj size 2300190 rat Bmd52 Bone mineral density QTL 52 6 11.2 1.0E-4 35963 D6Rat46 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) abnormal bone mineral density osteoporosis 2300109 18707222 6 580292 45580292 5 - by peak with adj size 6 1 35786687 5 - by peak with adj size intercross 10011 734475 COP/OlaHsd DA/OlaHsd 6 1 35623029 5 - by peak with adj size 6 1 27574569 5 - by peak with adj size 2300197 rat Scl59 Serum cholesterol level QTL 59 14 38070 D14Rat43 43032 D14Rat132 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) decreased circulating cholesterol level Hypercholesterolemia 2300117 18753676 1309450 Ppp4r3b Scl45 (sub_region) 14 78419915 110102984 1 - by flanking markers 14 79256324 107101727 1 - by flanking markers 2300195 EHC.BN-(D14Rat43-D14Rat132)/Kyu 14 78446303 110402569 1 - by flanking markers 14 55147478 100147478 4 - by one flank marker only 2300218 rat Hpcl2 Hepatic cholesterol level QTL 2 10 34100 D10Mgh3 69423 Srebf1 liver cholesterol amount (VT:0010498) liver cholesterol level (CMO:0001597) increased cholesterol level steatotic liver disease 1643359 18071061 69423 Srebf1 10 46348035 98640137 1 - by flanking markers 10 46483646 100090301 1 - by flanking markers intercross 2300217 SHR.BN-(D10Mgh3-Srebf1)/Ipcv 10 46593021 98939209 1 - by flanking markers 10 45029650 95600334 1 - by flanking markers 2300324 rat Fetw1 Fetal weight QTL 1 1 12.1 0.005 40.0 39312 D1Rat212 35569 D1Rat30 41498 D1Rat266 fetal growth trait (VT:0004201) fetal body weight (CMO:0002080) abnormal fetal growth/weight/body size Metabolic Syndrome 2300320 16914718 1 89791366 107050002 1 - by flanking markers 1 55540384 100540384 4 - by one flank marker only 61098 61099 BXH/Ipcv HXB/Ipcv 1 88634585 106002500 1 - by flanking markers 1 85424647 100358001 1 - by flanking markers 2300326 rat Plaw1 Placental weight QTL 1 15 15.0 0.005 43.0 36663 D15Rat21 41308 D15Rat107 40252 D15Rat101 placenta mass (VT:0004257) placenta wet weight (CMO:0002088) decreased placenta weight Metabolic Syndrome 2300320 16914718 15 79317523 112781949 1 - by flanking markers 15 74779702 109758846 4 - by one flank marker only 61098 61099 BXH/Ipcv HXB/Ipcv 15 75761024 109400896 1 - by flanking markers 15 68327165 100062518 1 - by flanking markers 2301398 rat Kidm38 Kidney mass QTL 38 10 0.002 1578983 D10Chm156 2875 Igfbp4 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 10 86759484 98999296 1 - by flanking markers 10 87834315 100429624 1 - by flanking markers 728384 SS.LEW-(D10Rat24-Igfbp4)/Ayd 10 86962563 99303173 1 - by flanking markers 10 84007272 95933025 1 - by flanking markers 2301400 rat Cm68 Cardiac mass QTL 68 3 0.001 728036 D3Chm60 39584 D3Rat206 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight hypertension 1599557 17143582 3 36274422 79557281 1 - by flanking markers 3 27762470 68832545 1 - by flanking markers 2301248 SS.LEW-(D3Got33-D3Chm68)/Ayd 3 31103589 72989078 1 - by flanking markers 3 31426403 70668733 1 - by flanking markers 2301402 rat Bp316 Blood pressure QTL 316 8 0.005 35018 D8Rat15 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1302764;1599557 15257171;17143582 8 60836747 105836747 4 - by one flank marker only 8 58548876 103548876 4 - by one flank marker only 1357180 SS.LEW-(D8Chm14-D8Rat16)/Ayd 8 61394378 106394378 4 - by one flank marker only 8 53968765 98968765 4 - by one flank marker only 2301404 rat Bp321 Blood pressure QTL 321 16 0.05 1358042 D16Chm66 39456 D16Rat88 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1599557 17143582 16 1534551 3405986 1 - by flanking markers 16 819369 3080748 1 - by flanking markers 2301247 SS.LEW-(D16Got3-D16Rat112)/Ayd 16 1550330 3439525 1 - by flanking markers 16 832380 2995225 1 - by flanking markers 2301405 rat Cm69 Cardiac mass QTL 69 10 0.031 1578987 D10Chm229 1578931 D10Chm171 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal heart weight 1599557;1559293 17143582;16286573 10 68361762 69797898 1 - by flanking markers 10 69555329 71032765 1 - by flanking markers 1579907 SS.LEW-(D10Chm128-D10Chm169)/Ayd 10 68697928 70167191 1 - by flanking markers 10 66319447 67750281 1 - by flanking markers 2301406 rat Kidm39 Kidney mass QTL 39 16 0.002 38834 D16Rat35 1358034 D16Chm63 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 16 3263508 17347173 1 - by flanking markers 16 2935812 16359278 1 - by flanking markers 1358161 SS.LEW-(D16Rat38-D16Chm66)/Ayd 16 3296688 17464293 1 - by flanking markers 16 2851709 15884239 1 - by flanking markers 2301408 rat Kidm36 Kidney mass QTL 36 2 0.002 10153 D2Wox37 2044 Adh1c kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 2 225014411 262102977 1 - by flanking markers 2 198324984 235811584 1 - by flanking markers 1358167 SS.MNS-(D2Wox27-Adh1)/Ayd 2 205583921 243562243 1 - by flanking markers 2 190613715 226808892 1 - by flanking markers 2301409 rat Cm70 Cardiac mass QTL 70 18 0.001 38430 D18Rat62 1578949 D18Chm91 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) abnormal heart weight 1599557 17143582 18 7012157 15053556 1 - by flanking markers 18 6934443 12677409 1 - by flanking markers 2301249 SS.LEW-(D18Rat30-D18Chm29)/Ayd 18 7057769 15274626 1 - by flanking markers 18 6791251 12205285 1 - by flanking markers 2301410 rat Bp317 Blood pressure QTL 317 18 0.004 11462 D18Wox7 40842 D18Rat101 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1578386;1599557 16278234;17143582 18 15314151 27453328 1 - by flanking markers 18 12406948 27431087 1 - by flanking markers 2301382 SS.LEW-(D18Chm91-D18Rat67)/Ayd 18 15539551 27743236 1 - by flanking markers 18 11944273 26548295 1 - by flanking markers 2301411 rat Bp320 Blood pressure QTL 320 3 0.001 35378 D3Rat61 43758 D3Wox1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1599557 17143582 3 158115782 182470017 1 - by flanking markers 3 147852788 168149595 1 - by flanking markers 2301246 SS.LEW-(D3Rat61-D3Wox1)/Ayd 3 153381237 174632112 1 - by flanking markers 3 145925360 166177555 1 - by flanking markers 2301412 rat Kidm40 Kidney mass QTL 40 17 0.001 12904060 D17Chm70 39318 D17Rat65 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557 17143582 17 43435496 88435496 4 - by one flank marker only 17 72287524 93930006 1 - by flanking markers 1559032 1559037 SS.LEW-(D17Rat65-D17Chm2)/Ayd SS.LEW-(D17Chm9-D17Rat97)/Ayd 17 41731080 86731080 4 - by one flank marker only 17 37479847 82479847 4 - by one flank marker only 2301413 rat Bp318 Blood pressure QTL 318 18 0.002 40842 D18Rat101 1579069 D18Chm56 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1578386;1599557;7421500 16278234;17143582;23814039 Bp347 (interacts with) 18 27453116 47711248 1 - by flanking markers 18 27430874 49015091 1 - by flanking markers 2301381 SS.LEW-(D18Chm41-D18Rat92)/Ayd 18 27743024 48499517 1 - by flanking markers 18 26548082 46969551 1 - by flanking markers 2301414 rat Kidm37 Kidney mass QTL 37 3 0.001 39584 D3Rat206 36717 D3Rat17 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) abnormal kidney weight 1599557;724791 17143582;14517349 3 79476405 133513825 1 - by flanking markers 3 68816911 121619110 1 - by flanking markers 1357981 SS.LEW-(D3Mco21-D3Rat17)/Ayd 3 72973445 127023997 1 - by flanking markers 3 70653097 121056321 1 - by flanking markers 2301415 rat Cm67 Cardiac mass QTL 67 2 0.003 66535 D2Mco8 3195 Npr1 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) abnormal aortic weight;abnormal heart weight;decreased kidney weight hypertension 1599557 17143582 2 192132537 209287892 1 - by flanking markers 2 158146823 182740242 1 - by flanking markers 1358172 SS.MNS-(D2Chm25-Fgg)/Ayd 2 172795683 189857032 1 - by flanking markers 2 152413072 175950118 1 - by flanking markers 2301416 rat Bp315 Blood pressure QTL 315 8 0.008 39028 D8Rat70 34723 D8Mgh9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1302764;1599557;7421500 15257171;17143582;23814039 Bp279 (interacts with);Bp310 (interacts with) 8 8714659 53714659 4 - by one flank marker only 8 7408118 52408118 4 - by one flank marker only 1357189 SS.LEW-(D8Rat56-D8Rat51)/Ayd 8 8738677 53738677 4 - by one flank marker only 8 7670578 52670578 4 - by one flank marker only 2301417 rat Bp319 Blood pressure QTL 319 18 0.002 37568 D18Rat55 62466 D18Uia6 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) abnormal systemic arterial blood pressure hypertension 1578386;1599557;8657072 16278234;17143582;21602714 1564431 Alpk2 18 53346348 78640858 1 - by flanking markers 18 54856551 79195912 1 - by flanking markers 2301386 SS.LEW-(D18Rat61-D18Rat45)/Ayd 18 54108375 79575348 1 - by flanking markers 18 52539763 76104388 1 - by flanking markers 2301962 rat Cm72 Cardiac mass QTL 72 13 4.12 10462 D13Mgh13 34567 D13Kid1 11232 D13Arb7 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) heart left ventricle hypertrophy hypertension 2301936 18925692 13 41256240 69865404 2 - by one flank and peak markers 13 23769973 68769973 5 - by peak with adj size intercross 10016 631602 GH/Omr BN/Elh 13 36147533 64868393 2 - by one flank and peak markers 13 31241331 58363171 2 - by one flank and peak markers 2301964 rat Bp323 Blood pressure QTL 323 6 4.3 33993 D6Mit2 11241 D6Mit3 33828 D6Mit9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 additive Bp322 (interacts with);Bp324 (interacts with) 6 85163291 94275468 1 - by flanking markers 6 75049644 84287190 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 6 75623393 84763275 1 - by flanking markers 6 72227641 81132889 1 - by flanking markers 2301966 rat Bp322 Blood pressure QTL 322 2 3.58 34204 D2Mgh7 34461 D2Mgh12 34292 D2Mgh8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 additive Bp323 (interacts with);Bp324 (interacts with) 2 177516922 235592880 1 - by flanking markers 2 156142685 210636169 1 - by flanking markers F2 intercross 10016 631602 GH/Omr BN/Elh 2 158159186 217498710 1 - by flanking markers 2 150540301 202447032 1 - by flanking markers 2301967 rat Cm73 Cardiac mass QTL 73 10 4.55 33585 D10Mit6 33690 D10Mit7 34669 D10Mgh20 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) heart left ventricle hypertrophy hypertension 2301936 18925692 10 14644150 92109374 2 - by one flank and peak markers 10 14721135 92841289 2 - by one flank and peak markers intercross 10016 631602 GH/Omr BN/Elh 10 14827894 92423564 2 - by one flank and peak markers 10 14487011 89062041 2 - by one flank and peak markers 2301969 rat Bp324 Blood pressure QTL 324 18 4.05 34290 D18Mgh4 34218 D18Mgh2 34270 D18Mgh6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 Bp322 (interacts with);Bp323 (interacts with) 18 61092546 79012526 1 - by flanking markers 18 62313296 79585008 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 18 61901354 79948616 1 - by flanking markers 18 59712417 76477814 1 - by flanking markers 2301970 rat Bw81 Body weight QTL 81 3 5.19 10678 D3Mgh21 34316 D3Mgh2 33808 D3Mit4 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 2301936 18925692 3 48366676 169801169 1 - by flanking markers 3 39052756 158038027 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 3 43295930 163640485 1 - by flanking markers 3 41874578 155617519 1 - by flanking markers 2301971 rat Cm71 Cardiac mass QTL 71 3 4.63 10678 D3Mgh21 34316 D3Mgh2 33808 D3Mit4 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) heart left ventricle hypertrophy hypertension 2301936 18925692 3 48366676 169801169 1 - by flanking markers 3 39052756 158038027 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 3 43295930 163640485 1 - by flanking markers 3 41874578 155617519 1 - by flanking markers 2301972 rat Bp325 Blood pressure QTL 325 6 4.8 34643 D6Pas1 11241 D6Mit3 33828 D6Mit9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2301936 18925692 6 7513619 85163291 1 - by flanking markers 6 7680593 75049644 1 - by flanking markers intercross 10016 631602 GH/Omr BN/Elh 6 1 75623393 2 - by one flank and peak markers 6 1 72227641 2 - by one flank and peak markers 2302038 rat Pia31 Pristane induced arthritis QTL 31 1 5.5 0.001 36550 D1Rat12 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Pia8 (maps to same region) 1 15026219 60026219 5 - by peak with adj size 17 1 26143121 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 1 13629251 58629251 5 - by peak with adj size 1 10992065 55992065 5 - by peak with adj size 2302040 rat Pia35 Pristane induced arthritis QTL 35 1 3.8 0.001 10445 D1Wox25 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Eae7 (maps to same region) 1 243714234 288714234 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 1 236265430 281265430 5 - by peak with adj size 1 216255568 260522016 5 - by peak with adj size 2302042 rat Pia38 Pristane induced arthritis QTL 38 12 3.5 0.001 11449 D12Wox14 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 Cia12 (maps to same region);Pia4 (maps to same region) 12 4514063 49514063 5 - by peak with adj size 12 568621 45568621 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 12 2513442 47513442 5 - by peak with adj size 12 1 44503507 5 - by peak with adj size 2302043 rat Pia27 Pristane induced arthritis QTL 27 11 18.6 0.001 10376 D11Wox6 11044 D11Wox5 11044 D11Wox5 blood immunoglobulin amount (VT:0002460) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 dominant 11 89808347 90495881 1 - by flanking markers 11 84560085 85432136 1 - by flanking markers intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 11 86714475 87444587 1 - by flanking markers 11 82566545 83440803 1 - by flanking markers 2302045 rat Pia39 Pristane induced arthritis QTL 39 14 4.9 0.001 38932 D14Rat36 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G2a level (CMO:0002116) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 recessive Pia6 (maps to same region) 14 10333529 55333529 5 - by peak with adj size 14 10539919 55539919 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 14 10539977 55539977 5 - by peak with adj size 14 8267090 53267090 5 - by peak with adj size 2302047 rat Pia34 Pristane induced arthritis QTL 34 19 5.8 0.001 33581 D19Mit1 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Eae8 (maps to same region) intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 2302049 rat Pia32 Pristane induced arthritis QTL 32 4 5.1 0.001 33933 D4Mit16 blood autoantibody amount (VT:0003725) serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 recessive Pia7 (interacts with) 4 169786277 214786277 5 - by peak with adj size 4 107728559 152728559 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 4 105277348 150277348 5 - by peak with adj size 4 105789505 150789505 5 - by peak with adj size 2302051 rat Pia28 Pristane induced arthritis QTL 28 4 5.3 0.001 35325 D4Rat41 blood autoantibody amount (VT:0003725) serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive 4 140044845 185044845 5 - by peak with adj size 4 74123346 119123346 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 4 75258970 120258970 5 - by peak with adj size 4 73630210 118630210 5 - by peak with adj size 2302053 rat Pia33 Pristane induced arthritis QTL 33 5 5.0 0.001 11072 D5Mgh2 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G level (CMO:0002102) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 dominant 16 39315759 84315759 3 - by peak only 5 1 40017184 3 - by peak only intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 2302055 rat Pia30 Pristane induced arthritis QTL 30 3 3.5 0.001 11263 D3Wox14 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 3 35956364 80956364 5 - by peak with adj size 3 25222506 70222506 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 3 29321714 74321714 5 - by peak with adj size 3 27936919 72936919 5 - by peak with adj size 2302057 rat Pia29 Pristane induced arthritis QTL 29 16 3.6 0.001 34007 D16Mit3 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 recessive 16 24569673 69569673 5 - by peak with adj size 16 24934312 69934312 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 16 24846541 69846541 5 - by peak with adj size 16 21735975 66735975 5 - by peak with adj size 2302059 rat Pia36 Pristane induced arthritis QTL 36 1 3.8 0.001 11144 D1Wox11 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 Cia2 (maps to same region) 1 40899304 85899304 5 - by peak with adj size 1 41645883 86645883 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 1 41907249 86907249 5 - by peak with adj size 1 43333002 88333002 5 - by peak with adj size 2302060 rat Pia37 Pristane induced arthritis QTL 37 12 6.1 0.001 34070 D12Mgh7 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) increased susceptibility to induced arthritis;joint swelling rheumatoid arthritis 2302026 14674011 additive Apr1 (maps to same region) 12 20591035 54450796 5 - by peak with adj size 12 14334630 46782294 5 - by peak with adj size intercross 634373 634374 DA/ZtmRhd E3/ZtmRhd 12 18729043 52716770 5 - by peak with adj size 12 13198157 46669029 5 - by peak with adj size 2302273 rat Gluco35 Glucose level QTL 35 3 5.3 0.001 42126 D3Arb18 33901 D3Mit12 33901 D3Mit12 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 Gluco39 (maps to same region) 3 90520542 126035097 1 - by flanking markers 3 79283621 114574752 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 3 83817637 119509260 1 - by flanking markers 3 80800231 114297550 1 - by flanking markers 2302275 rat Gluco37 Glucose level QTL 37 13 3.8 36922 D13Rat4 11375 D13Arb8 41978 D13Arb5 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 13 19680631 56629737 1 - by flanking markers 13 1265159 47698301 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 13 14441582 51577031 1 - by flanking markers 13 11929449 46193066 1 - by flanking markers 2302276 rat Bw82 Body weight QTL 82 3 4.32 34336 D3Mgh7 42139 D3Arb8 11261 D3Wox9 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 2298688 18612083 Bw117 (maps to same region);Bw24 (maps to same region);Bw31 (maps to same region);Bw36 (maps to same region) 3 45609749 71439037 1 - by flanking markers 3 36556706 60697201 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 3 40523593 64880586 1 - by flanking markers 3 39454637 62951183 1 - by flanking markers 2302277 rat Gluco38 Glucose level QTL 38 14 5.8 33953 D14Mit1 34890 D14Rat9 67231 D14Arb18 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 Bw5 (maps to same region);Pia6 (maps to same region) 14 12623297 29969376 1 - by flanking markers 14 12386493 30087990 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 14 12680424 30155192 1 - by flanking markers 14 11030622 28035204 1 - by flanking markers 2302278 rat Gluco36 Glucose level QTL 36 8 4.2 40746 D8Rat162 33973 D8Mit2 36117 D8Rat46 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level diabetes mellitus 2298688 18612083 Niddm21 (maps to same region) 8 32227585 52686094 1 - by flanking markers 8 30878636 53049477 1 - by flanking markers intercross 631219 1302627 SDT/Jcl F344/NSlc 8 32201981 54065241 1 - by flanking markers 8 29502665 50095447 1 - by flanking markers 2302365 rat Gluco40 Glucose level QTL 40 17 4.79 16.7 45514 D17Wox8 45485 D17Wox9 33707 D17Mit5 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome 619689 10720472 17 63969577 87905751 1 - by flanking markers 17 65900518 93489534 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 17 62195822 86194199 1 - by flanking markers 17 57246843 82046127 1 - by flanking markers 2302367 rat Slep5 Serum leptin concentration QTL 5 8 3.43 33858 D8Mit4 33628 D8Mit6 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 619689 10720472 8 11331573 44187546 1 - by flanking markers 8 9581375 44484215 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 8 11373509 45712344 1 - by flanking markers 8 9712463 41866876 1 - by flanking markers 2302369 rat Scl60 Serum cholesterol level QTL 60 5 3.13 34210 D5Mgh14 34206 D5Mgh15 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased circulating cholesterol level Metabolic Syndrome 619689 10720472 5 153255850 171364652 1 - by flanking markers 5 150236110 167844737 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 5 149568588 167739697 1 - by flanking markers 5 143608201 161165651 1 - by flanking markers 2302371 rat Stl22 Serum triglyceride level QTL 22 4 5.15 18.2 10800 D4Wox27 33757 D4Mit2 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome 619689 10720472 4 3096322 55539285 1 - by flanking markers 4 460493 55370202 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 4 3044017 55791834 1 - by flanking markers 4 5218294 57114705 1 - by flanking markers 2302373 rat Gluco39 Glucose level QTL 39 3 5.01 24.2 34240 D3Mgh1 34228 D3Mgh5 33927 D3Mit3 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level Metabolic Syndrome 619689;2298688 10720472;18612083 recessive Gluco35 (maps to same region) 3 109733980 176999783 1 - by flanking markers 3 97524000 163778606 1 - by flanking markers 737957 1357345 WOKW/K DA/K 3 103141944 170934860 1 - by flanking markers 3 98535386 161695835 1 - by flanking markers 2302375 rat Bw83 Body weight QTL 83 1 4.87 2.0E-4 30.7 33753 D1Mit5 10674 D1Mgh12 body mass (VT:0001259) body weight (CMO:0000012) increased body mass index;increased body weight Metabolic Syndrome;obesity 619689 10720472 Bw18 (maps to same region);Niddm1 (maps to same region);Niddm7 (maps to same region) 1 222606650 270717037 1 - by flanking markers 1 202790380 247322277 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 1 215711860 260711860 4 - by one flank marker only 1 197697768 242697768 4 - by one flank marker only 2302377 rat Scl61 Serum cholesterol level QTL 61 17 4.36 12.5 33790 D17Mit3 45450 D17Wox3 33882 D17Mit2 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) increased circulating cholesterol level Metabolic Syndrome 619689 10720472 17 29981162 54244197 1 - by flanking markers 17 33639527 62009961 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 17 28073589 56207236 1 - by flanking markers 17 27389946 53481766 1 - by flanking markers 2302378 rat Insul11 Insulin level QTL 11 1 3.25 33959 D1Mit3 10674 D1Mgh12 33753 D1Mit5 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level Metabolic Syndrome 619689 10720472 dominant 1 162692213 270717037 1 - by flanking markers 1 146971846 247322277 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 1 156446196 274977688 2 - by one flank and peak markers 1 144267353 251128347 2 - by one flank and peak markers 2302380 rat Slep6 Serum leptin concentration QTL 6 16 3.36 10660 D16Mgh3 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 619689 10720472 16 1 31479065 5 - by peak with adj size 16 1 32464321 5 - by peak with adj size intercross 737957 1357345 WOKW/K DA/K 16 1 33160624 5 - by peak with adj size 16 1 32139025 5 - by peak with adj size 2302381 rat Bw84 Body weight QTL 84 5 4.47 15.9 34216 D5Mgh6 34041 D5Mit5 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) increased body mass index;increased body weight Metabolic Syndrome;obesity 619689 10720472 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers intercross 737957 1357345 WOKW/K DA/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 2303028 rat Bp329 Blood pressure QTL 329 13 42997 D13Rat179 45069 D13Got53 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678;10755344 17566075;22912817 3654;67366;619761;620349 Sele;Pla2g4a;Fmo3;Ptgs2 Bp328 (interacts with);Bp387 (maps to same region) 13 68591963 83929327 1 - by flanking markers 13 60669450 76779489 1 - by flanking markers intercross 2302984 SS.BN-(D13Rat151-D13Rat197)/Mcwi 13 63611283 79034003 1 - by flanking markers 13 58497872 73485113 1 - by flanking markers 2303030 rat Bp327 Blood pressure QTL 327 13 39804 D13Rat111 39208 D13Rat88 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 2446;620465 Ctse;Cxcr4 Bp326 (interacts with);Bp328 (interacts with) 13 40421740 51509512 1 - by flanking markers 13 32030139 42627837 1 - by flanking markers intercross 2302985 SS.BN-(D13Rat111-D13Got22)/Mcwi 13 35301263 46444796 1 - by flanking markers 13 30395351 41184251 1 - by flanking markers 2303031 rat Bp326 Blood pressure QTL 326 13 35975 D13Rat7 39032 D13Rat60 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 Bp327 (interacts with);Bp328 (interacts with) 13 19518130 32069874 1 - by flanking markers 13 1084268 13053933 1 - by flanking markers intercross 2302987 SS.BN-(D13Rat7-D13Rat60)/Mcwi 13 14279081 26919398 1 - by flanking markers 13 11766535 23001904 1 - by flanking markers 2303032 rat Bp328 Blood pressure QTL 328 13 39208 D13Rat88 38240 D13Rat91 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 1625678 17566075 2048;3554;621137;1303151 Adora1;Ren;Rnpep;Adipor1 Bp326 (interacts with);Bp327 (interacts with);Bp329 (interacts with) 13 51509286 55853202 1 - by flanking markers 13 42627610 46912163 1 - by flanking markers intercross 2293145 SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi 13 46444570 50799665 1 - by flanking markers 13 41184022 45417941 1 - by flanking markers 2303118 rat Mamtr7 Mammary tumor resistance QTL 7 10 0.003 37526 D10Rat91 41584 D10Rat135 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) decreased incidence of tumors by chemical induction;increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 2302423 19052818 10 8619955 108145987 1 - by flanking markers 10 9762188 108776963 1 - by flanking markers intercross 2303116 SPRD.WKY-(D10Rat91-D10Rat135)/Ibmm 10 9841807 108540162 1 - by flanking markers 10 9658275 104670812 1 - by flanking markers 2303120 rat Mamtr8 Mammary tumor resistance QTL 8 18 0.001 10689 D18Mit5 39278 D18Rat44 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) decreased incidence of tumors by chemical induction;increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms;adenocarcinoma 2302423 19052818 18 32348154 86114102 1 - by flanking markers 18 32458819 86863412 1 - by flanking markers intercross 1599760 SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm 18 32670352 87080053 1 - by flanking markers 18 31359408 83218561 1 - by flanking markers 2303168 rat Bp330 Blood pressure QTL 330 4 4.25 0.017 2901 Il6 34367 D4Mgh8 11015 D4Mit24 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial systolic blood pressure Hypotension 2303163 8829824 3197 Npy 4 3095536 208551950 1 - by flanking markers 4 456799 149181446 1 - by flanking markers intercross 61119 1302620 WKY/NCrlCrlj SHR/Kyo 4 3043231 145254791 1 - by flanking markers 4 5214602 146446691 1 - by flanking markers 2303170 rat Bp332 Blood pressure QTL 332 9 3.73 0.027 11312 D9Bro1 33842 D9Mit6 10404 D9Mit2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial systolic blood pressure hypertension 2303163;2302803 8829824;18854752 2421 Crygc Bp333 (maps to same region) 9 59092893 82501727 2 - by one flank and peak markers 9 1526958 74813097 1 - by flanking markers intercross 61119 1302620 WKY/NCrlCrlj SHR/Kyo 9 60810298 82732466 2 - by one flank and peak markers 9 55847841 77026453 2 - by one flank and peak markers 2303171 rat Bp331 Blood pressure QTL 331 8 5.57 0.005 34415 D8Mgh6 10054 D8Wox10 10054 D8Wox10 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2303163 8829824 3346 Plcd1 8 65466908 127239811 1 - by flanking markers 8 64762472 124310219 1 - by flanking markers intercross 61119 1302620 WKY/NCrlCrlj SHR/Kyo 8 65717449 128033050 1 - by flanking markers 8 61290298 119084929 1 - by flanking markers 2303178 rat Bp334 Blood pressure QTL 334 9 3.7 0.01 61287 D9Uia6 2302873 D9Mco93 44654 D9Got111 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) decreased mean systemic arterial blood pressure 2302803;6903249 18854752;21814219 Bp108 (interacts with);Bp34 (interacts with);Pur31 (sub_region) 9 83451810 97845437 1 - by flanking markers 9 77170797 90249887 1 - by flanking markers intercross 2303153 SS.SHR-(D9Rat7-D9Mco93)/Mco 9 83686153 98164303 1 - by flanking markers 9 79271511 91616855 1 - by flanking markers 2303180 rat Bp333 Blood pressure QTL 333 9 0.001 2302913 D9Mco76 2302927 D9Mco85 44654 D9Got111 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005);mean arterial blood pressure (CMO:0000009);systolic blood pressure (CMO:0000004) decreased mean systemic arterial blood pressure;decreased urine protein level 2302803;6903249 18854752;21814219 Bp108 (maps to same region);Bp284 (maps to same region);Bp332 (maps to same region);Bp34 (maps to same region);Bp356 (sub_region);Cm28 (maps to same region) 9 61414200 82659881 1 - by flanking markers 9 53933135 76456066 1 - by flanking markers intercross 2303154 SS.SHR-(D9Wox16-D9Mco85)/Mco 9 61730923 82890620 1 - by flanking markers 9 56627713 78595166 1 - by flanking markers 2303559 rat Gluco54 Glucose level QTL 54 9 2.0 40738 D9Rat130 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Despr5 (maps to same region);Niddm26 (maps to same region) 9 3833388 48833388 5 - by peak with adj size 9 1 42602240 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 9 4986095 49986095 5 - by peak with adj size 9 1254084 46254084 5 - by peak with adj size 2303561 rat Bw91 Body weight QTL 91 17 2.0 36225 D17Rat15 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw32 (maps to same region);Bw67 (maps to same region) 17 11720316 56720316 5 - by peak with adj size 17 15228042 60228042 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 17 9827304 54827304 5 - by peak with adj size 17 8868462 53868462 5 - by peak with adj size 2303563 rat Bw89 Body weight QTL 89 13 6.0 35997 D13Rat26 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 13 42337041 87337041 5 - by peak with adj size 13 34327911 79327911 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 13 37346348 82346348 5 - by peak with adj size 13 32284471 77284471 5 - by peak with adj size 2303564 rat Gluco43 Glucose level QTL 43 8 3.0 36872 D8Rat43 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 8 28742006 73742006 5 - by peak with adj size 8 29077622 74077622 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 8 30144800 75144800 5 - by peak with adj size 8 26130187 71130187 5 - by peak with adj size 2303566 rat Bw90 Body weight QTL 90 16 2.0 42022 D16Arb5 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 16 1 41109533 5 - by peak with adj size 16 1 40096603 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 16 1 41240937 5 - by peak with adj size 16 1 39533930 5 - by peak with adj size 2303568 rat Bw88 Body weight QTL 88 12 3.0 40394 D12Rat89 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw120 (maps to same region);Bw15 (maps to same region) 12 1 26466956 5 - by peak with adj size 12 1 25457135 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303569 rat Gluco44 Glucose level QTL 44 12 2.0 39332 D12Rat52 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm27 (maps to same region) 12 20209592 54450796 5 - by peak with adj size 12 13948769 46782294 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 12 18342477 52716770 5 - by peak with adj size 12 12812385 46669029 5 - by peak with adj size 2303570 rat Gluco48 Glucose level QTL 48 8 2.0 36416 D8Rat31 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 8 52418503 97418503 5 - by peak with adj size 8 53621297 98621297 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 8 55659105 100659105 5 - by peak with adj size 8 49805831 94805831 5 - by peak with adj size 2303571 rat Bw92 Body weight QTL 92 18 3.0 41878 D18Rat121 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 18 51056414 87229863 5 - by peak with adj size 18 51949129 87265094 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 18 51375816 88201929 5 - by peak with adj size 18 48520044 83828827 5 - by peak with adj size 2303572 rat Insul13 Insulin level QTL 13 8 2.0 36872 D8Rat43 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) increased circulating insulin level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm11 (maps to same region) 8 28742006 73742006 5 - by peak with adj size 8 29077622 74077622 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 8 30144800 75144800 5 - by peak with adj size 8 26130187 71130187 5 - by peak with adj size 2303574 rat Gluco42 Glucose level QTL 42 5 2.0 36689 D5Rat14 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive Niddm25 (maps to same region) 5 60025669 105025669 5 - by peak with adj size 5 57040762 102040762 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 5 55903593 100903593 5 - by peak with adj size 5 53496719 98496719 5 - by peak with adj size 2303575 rat Insul14 Insulin level QTL 14 12 4.0 40702 D12Rat69 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) increased circulating insulin level Metabolic Syndrome 2303512;2312611 19697080 additive 12 2495424 47495424 5 - by peak with adj size 12 1 43562201 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 12 492578 45492578 5 - by peak with adj size 12 1 42450532 5 - by peak with adj size 2303576 rat Gluco45 Glucose level QTL 45 1 4.0 39116 D1Rat145 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303577 rat Gluco47 Glucose level QTL 47 5 3.0 40386 D5Rat131 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive Srcrtb2 (maps to same region) 5 16877438 61877438 5 - by peak with adj size 5 12890569 57890569 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303578 rat Gluco50 Glucose level QTL 50 20 2.0 37792 D20Rat29 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive 20 28247365 57791882 5 - by peak with adj size 20 25555772 55268282 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 20 26608843 56205956 5 - by peak with adj size 20 25106722 54435887 5 - by peak with adj size 2303579 rat Insul12 Insulin level QTL 12 1 4.0 39116 D1Rat145 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) increased circulating insulin level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm35 (maps to same region) 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303580 rat Gluco49 Glucose level QTL 49 17 2.0 36526 D17Rat46 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 619766 Cdc123 additive 17 55646725 92503511 5 - by peak with adj size 17 61100283 97296363 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 17 53991947 90843779 5 - by peak with adj size 17 50040271 86533673 5 - by peak with adj size 2303581 rat Bw85 Body weight QTL 85 1 4.0 39116 D1Rat145 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw115 (maps to same region);Bw123 (maps to same region);Bw80 (maps to same region);Niddm45 (maps to same region);Niddm58 (maps to same region) 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303582 rat Gluco53 Glucose level QTL 53 7 3.0 36731 D7Rat24 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm19 (maps to same region);Sradr5 (maps to same region) intercross 61105 61109 WKY/NHsd F344/NHsd 2303584 rat Gluco55 Glucose level QTL 55 18 2.0 41878 D18Rat121 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive 18 51056414 87229863 5 - by peak with adj size 18 51949129 87265094 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 18 51375816 88201929 5 - by peak with adj size 18 48520044 83828827 5 - by peak with adj size 2303585 rat Bw86 Body weight QTL 86 4 4.0 39194 D4Rat115 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 4 12496123 57496123 5 - by peak with adj size 4 11706134 56706134 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 4 12638974 57638974 5 - by peak with adj size 4 14678065 59678065 5 - by peak with adj size 2303586 rat Gluco52 Glucose level QTL 52 5 2.0 40262 D5Rat157 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm30 (maps to same region) intercross 61105 61109 WKY/NHsd F344/NHsd 2303587 rat Bw93 Body weight QTL 93 20 13.0 37792 D20Rat29 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive 20 28247365 57791882 5 - by peak with adj size 20 25555772 55268282 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 20 26608843 56205956 5 - by peak with adj size 20 25106722 54435887 5 - by peak with adj size 2303589 rat Bw87 Body weight QTL 87 10 2.0 41042 D10Rat134 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome 2303512;2312611 19697080 additive Bw57 (maps to same region) 10 84714875 112200500 5 - by peak with adj size 10 86057484 110718848 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 10 85079943 112626471 5 - by peak with adj size 10 81285008 107211142 5 - by peak with adj size 2303591 rat Gluco41 Glucose level QTL 41 1 2.0 35057 D1Rat39 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm23 (maps to same region) 1 110672269 155672269 5 - by peak with adj size 1 103483490 148483490 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 1 109634374 154634374 5 - by peak with adj size 1 102168504 147168504 5 - by peak with adj size 2303592 rat Gluco51 Glucose level QTL 51 1 3.0 39116 D1Rat145 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level Metabolic Syndrome 2303512;2312611 19697080 additive Niddm1 (maps to same region);Niddm24 (maps to same region);Niddm35 (maps to same region);Niddm44 (maps to same region);Niddm64 (maps to same region);Niddm65 (maps to same region);Niddm66 (maps to same region);Niddm7 (maps to same region) 1 247303551 290094216 5 - by peak with adj size 1 225366432 267910886 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 2303593 rat Gluco46 Glucose level QTL 46 3 3.0 41162 D3Rat181 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating glucose level Metabolic Syndrome 2312611;2303512 19697080 additive Despr11 (maps to same region);Srcrt2 (maps to same region) 3 36534996 81534996 5 - by peak with adj size 3 25754538 70754538 5 - by peak with adj size intercross 61105 61109 WKY/NHsd F344/NHsd 3 29908255 74908255 5 - by peak with adj size 3 28468571 73468571 5 - by peak with adj size 2303615 rat Vencon7 Ventilatory control QTL 7 5 0.001 38740 D5Rat113 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 5 57457500 102457500 5 - by peak with adj size 5 54207464 99207464 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 5 53309568 98309568 5 - by peak with adj size 5 50983895 95983895 5 - by peak with adj size 2303618 rat Vencon1 Ventilatory control QTL 1 5 3.8 40262 D5Rat157 respiration trait (VT:0001943) oxygen consumption (CMO:0002169) 2303609 intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 2303620 rat Vencon4 Ventilatory control QTL 4 3 3.9 36826 D3Rat12 36745 D3Rat1 36826 D3Rat12 respiration trait (VT:0001943) tidal volume (CMO:0000222) 2303609 3 139333901 180128021 1 - by flanking markers 3 127988419 170016653 1 - by flanking markers intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 3 132875075 176418101 1 - by flanking markers 3 127162703 168026850 1 - by flanking markers 2303622 rat Vencon6 Ventilatory control QTL 6 1 0.001 37870 D1Rat170 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 1 177035811 222035811 5 - by peak with adj size 1 158856292 203856292 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 1 169971964 214971964 5 - by peak with adj size 1 154561505 199561505 5 - by peak with adj size 2303623 rat Vencon2 Ventilatory control QTL 2 4 3.8 36926 D4Rat66 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 2303609 4 201935420 246935420 5 - by peak with adj size 4 138523557 183523557 5 - by peak with adj size 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 4 134917642 179917642 5 - by peak with adj size 4 135204660 180204660 5 - by peak with adj size 2303624 rat Vencon5 Ventilatory control QTL 5 6 4.45 35198 D6Rat11 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 2303609 6 102134434 147134434 5 - by peak with adj size 6 92738204 137738204 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 6 92879510 137879510 5 - by peak with adj size 6 88047916 133047916 5 - by peak with adj size 2303626 rat Vencon10 Ventilatory control QTL 10 20 0.001 38760 D20Rat39 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 20 22585245 57791882 5 - by peak with adj size 20 19840721 55268282 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 20 20858470 56205956 5 - by peak with adj size 20 19190721 54435887 5 - by peak with adj size 2303627 rat Vencon8 Ventilatory control QTL 8 17 0.001 34827 D17Rat12 respiration trait (VT:0001943) tidal volume (CMO:0000222) 2303609 17 7105265 52105265 5 - by peak with adj size 17 10777341 55777341 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 17 5191047 50191047 5 - by peak with adj size 17 4528038 49528038 5 - by peak with adj size 2303628 rat Vencon9 Ventilatory control QTL 9 19 0.005 35547 D19Rat25 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 2303609 19 20855340 65855340 5 - by peak with adj size 19 8121935 53121935 5 - by peak with adj size intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 2303629 rat Vencon3 Ventilatory control QTL 3 7 7.25 39016 D7Rat103 36099 D7Rat25 41106 D7Rat147 respiration trait (VT:0001943) respiration rate (CMO:0000289) 2303609 7 47909781 63596644 1 - by flanking markers 7 44462790 60576660 1 - by flanking markers intercross 2303610 2303611 SD/HsdCwr BN/HsdMcwiCwr 7 47895099 63372754 1 - by flanking markers 7 41109692 56793354 1 - by flanking markers 2305926 rat Iddm37 Insulin dependent diabetes mellitus QTL 37 20 6.0 40208 D20Rat47 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) insulitis type 1 diabetes mellitus 2305925;2313174 19720792 69418 Ubd additive Iddm14 (interacts with) 20 4059279 49059279 4 - by one flank marker only 20 1616332 46616332 4 - by one flank marker only 2313181 2313209 LEW.1WR1/WorBrm WF.ART2/Wor 20 2018654 47018654 4 - by one flank marker only 20 1527842 46527842 4 - by one flank marker only 2306545 rat Iddm39 Insulin dependent diabetes mellitus QTL 39 4 43814 D4Got59 738065 D4Rhw6 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased susceptibility to autoimmune diabetes;insulitis type 1 diabetes mellitus 2306526;6480201 19351909;21925515 628765;628871;1305041;1564570;1565750 Gimap4;Gimap5;Gimap6;Gimap8;Gimap7 4 142703528 143059388 1 - by flanking markers 4 76492967 76829366 1 - by flanking markers 2306543 BBDR.F344-(D4Got59-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/Rhw 4 78039977 78371222 1 - by flanking markers 4 77356721 77687411 1 - by flanking markers 2306547 rat Iddm38 Insulin dependent diabetes mellitus QTL 38 4 39266 D4Rat102 36181 D4Rat26 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased susceptibility to autoimmune diabetes;insulitis type 1 diabetes mellitus 2306526 19351909 4 66205169 135563631 1 - by flanking markers 4 66220947 69183485 1 - by flanking markers 2306533 BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/2Rhw 4 66394000 70773654 1 - by flanking markers 4 67386669 70362197 1 - by flanking markers 2306787 rat Ean3 Experimental allergic neuritis QTL 3 10 3.1 11479 D10Mit8 41468 D10Rat155 1637892 D10Got236 nervous system integrity trait (VT:0010566) body weight loss (CMO:0001399) demyelination;muscle weakness;weight loss Body Weight Changes;Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 Cia27 (maps to same region);Eae18a (maps to same region) 10 55422036 69020609 1 - by flanking markers 10 55851702 70229954 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 10 55678976 69385767 1 - by flanking markers 10 53797385 66979128 1 - by flanking markers 2306789 rat Ean6 Experimental allergic neuritis QTL 6 12 4.9 11051 D12Mit2 36025 D12Rat23 44974 D12Got48 nervous system integrity trait (VT:0010566) experimental autoimmune neuritis severity score (CMO:0001528) demyelination;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 61307 Ncf1 Eae5 (maps to same region);Pia4 (maps to same region) 12 24662983 29163190 1 - by flanking markers 12 20932559 25367251 1 - by flanking markers 2306784 Kini:DA,PVG-G12 12 22650702 27190240 1 - by flanking markers 12 19610870 24139202 1 - by flanking markers 2306790 rat Ean1 Experimental allergic neuritis QTL 1 20 0.05 nervous system integrity trait (VT:0010566) experimental autoimmune neuritis severity score (CMO:0001528) demyelination;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306736 15342198 intercross 737657 LEW.1AV1 2306792 rat Ean4 Experimental allergic neuritis QTL 4 10 4.0 39750 D10Rat190 66715 D10Mco15 40628 D10Rat142 nervous system integrity trait (VT:0010566) IFNG-secreting splenocyte count (CMO:0002122) abnormal interferon-gamma secretion;demyelination;increased T cell proliferation;increased activated T cell number;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 co-recessive Oia4 (maps to same region) 10 86774898 97028928 1 - by flanking markers 10 87849516 98392508 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 10 86977861 97308569 1 - by flanking markers 10 84022321 93995963 1 - by flanking markers 2306793 rat Ean5 Experimental allergic neuritis QTL 5 10 4.7 66715 D10Mco15 39114 D10Rat87 39114 D10Rat87 nervous system integrity trait (VT:0010566) IFNG-secreting splenocyte count (CMO:0002122) abnormal interferon-gamma secretion;demyelination;increased T cell proliferation;increased activated T cell number;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 Oia3 (maps to same region) 10 75057195 97028717 1 - by flanking markers 10 76043832 98392296 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 10 75045391 97308358 1 - by flanking markers 10 72552416 93995749 1 - by flanking markers 2306794 rat Ean2 Experimental allergic neuritis QTL 2 4 6.4 38262 D4Rat103 36978 D4Rat38 40586 D4Rat231 nervous system integrity trait (VT:0010566) IFNG-secreting splenocyte count (CMO:0002122) abnormal interferon-gamma secretion;demyelination;increased T cell proliferation;increased activated T cell number;muscle weakness Experimental Autoimmune Neuritis;Guillain-Barre syndrome;Muscle Weakness 2306769 19299744 Cia3 (maps to same region) 4 149135946 162264045 1 - by flanking markers 4 82700691 96313512 1 - by flanking markers intercross 2306784 Kini:DA,PVG-G12 4 84475257 97479149 1 - by flanking markers 4 83428419 95853334 1 - by flanking markers 2306821 rat Bp335 Blood pressure QTL 335 7 0.001 1627404 D7Mco19 66604 D7Mco7 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 629613;2306800 12682779;19255363 2453;62037;1306132;1306316;1307850;1312017;1359378 Cyp11b1;Arc;Ly6d;Jrk;Gml;Lynx1;Them6 Bp169 (sub_region);Bp285 (interacts with);Bp286 (interacts with) 7 115828017 116100169 1 - by flanking markers 7 112800232 113014423 1 - by flanking markers intercross 2306816 SS.SR-(D7Mco19-D7Mco7)/Jr 7 115922628 145729302 4 - by one flank marker only 7 106571501 135012528 4 - by one flank marker only 2306850 rat Pia40 Pristane induced arthritis QTL 40 20 1.0E-4 41466 D20Rat45 40208 D20Rat47 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) decreased susceptibility to induced joint inflammation;joint inflammation Experimental Arthritis 2306838 19180494 20 4059395 8810219 1 - by flanking markers 20 1616449 5447380 1 - by flanking markers intercross 2306842 E3.DA-(D20Rat45-D20Rat47)/Rhd 20 2018770 6567419 1 - by flanking markers 20 1527959 5304575 1 - by flanking markers 2306899 rat Bp338 Blood pressure QTL 338 4 0.071 36870 D4Rat33 35635 D4Rat54 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 codominant Bp21 (maps to same region) 4 146540904 184799673 1 - by flanking markers 4 80205349 121829076 1 - by flanking markers intercross 2306894 SHR.BN-(D4Rat33-D4Rat54)/Jk 4 81874073 119546974 1 - by flanking markers 4 81006124 120102625 1 - by flanking markers 2306901 rat Bp337 Blood pressure QTL 337 2 0.01 40954 D2Rat226 36081 D2Rat294 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 recessive Bp19 (maps to same region) 2 197020226 262435073 1 - by flanking markers 2 170338294 236153712 1 - by flanking markers intercross 2306895 SHR.BN-(D2Rat226-D2Rat294)/Jk 2 177680772 243901375 1 - by flanking markers 2 164073756 227146641 1 - by flanking markers 2306902 rat Bp339 Blood pressure QTL 339 16 0.01 40724 D16Rat87 34066 D16Mgh1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 recessive Bp23 (maps to same region) 16 4082652 45651269 1 - by flanking markers 16 3464719 46137590 1 - by flanking markers intercross 2306893 SHR.BN-(D16Rat87-D16Mgh1)/Jk 16 4136355 45905331 1 - by flanking markers 16 3380150 43025077 1 - by flanking markers 2306903 rat Bp336 Blood pressure QTL 336 2 0.01 37558 D2Rat114 37952 D2Rat123 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 2306880 19126752 codominant Bp18 (maps to same region) 2 55361257 131889716 1 - by flanking markers 2 36432989 112326568 1 - by flanking markers intercross 2306892 SHR.BN-(D2Rat114-D2Rat123)/Jk 2 36245223 112175725 1 - by flanking markers 2 64366971 109366971 4 - by one flank marker only 2306968 rat Anxrr23 Anxiety related response QTL 23 15 4.83 34910 D15Rat14 35611 D15Rat11 45269 D15Wox3 reflex trait (VT:0001961) amplitude of the acoustic startle response (CMO:0001520) increased anxiety-related response 625384;10053640 11932246;21029000 additive Srcrt8 (maps to same region) 15 48493430 56554042 1 - by flanking markers 15 45870097 51526246 1 - by flanking markers intercross 2306961 2306962 RLA/Verh RHA/Verh 15 43097470 52831189 1 - by flanking markers 15 40631268 46187442 1 - by flanking markers 2306970 rat Anxrr22 Anxiety related response QTL 22 10 5.95 34445 D10Mgh6 38844 D10Rat101 36019 D10Rat18 fear/anxiety-related behavior trait (VT:1000241) number of periods of voluntary immobility (CMO:0001045) increased anxiety-related response 625384 11932246 additive 10 63366082 101365609 1 - by flanking markers 10 67677924 102796362 1 - by flanking markers intercross 2306961 2306962 RLA/Verh RHA/Verh 10 64648175 101691360 1 - by flanking markers 10 61345276 98211570 1 - by flanking markers 2306971 rat Anxrr21 Anxiety related response QTL 21 5 9.47 38768 D5Rat100 60485 D5Got42 43930 D5Wox4 fear/anxiety-related behavior trait (VT:1000241) number of entries into a discrete space in an experimental apparatus (CMO:0000960) decreased grooming behavior;impaired passive avoidance behavior;increased anxiety-related response 2313899;625384 18971309;11932246 additive 5 70180341 132878299 1 - by flanking markers 5 68843563 130756605 1 - by flanking markers intercross 2306961 2306962 RLA/Verh RHA/Verh 5 65696672 129038896 1 - by flanking markers 5 66174080 124160948 1 - by flanking markers 2307172 rat Activ4 Activity QTL 4 16 3.71 2.3E-4 39200 D16Rat32 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity;increased exploration in new environment acute stress disorder 2306974 19089625 16 1 32781388 5 - by peak with adj size 16 1 33735317 5 - by peak with adj size intercross 61008 2292168 WAG ISIAH 16 1 34465490 5 - by peak with adj size 16 1 33418960 5 - by peak with adj size 2307174 rat Activ3 Activity QTL 3 2 4.83 5.8E-5 38280 D2Rat157 36876 D2Rat88 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) hyperactivity;increased exploration in new environment acute stress disorder 2306974 19089625 2 241761764 248335979 1 - by flanking markers 2 216711618 222281918 1 - by flanking markers intercross 61008 2292168 WAG ISIAH 2 183984665 228984665 4 - by one flank marker only 2 168594495 213594495 4 - by one flank marker only 2312418 rat Kidm41 Kidney mass QTL 41 12 3.7 1.0E-4 11052 D12Wox11 41958 D12Arb14 kidney mass (VT:0002707) single kidney wet weight to body weight ratio (CMO:0000622) decreased kidney weight anti-basement membrane glomerulonephritis 2312387 19448344 recessive 12 4344844 24663198 2 - by one flank and peak markers 12 665384 20932760 2 - by one flank and peak markers 61111 1358112 DA/Slc WKY/NCrl 12 1 22650917 4 - by one flank marker only 12 1 19611090 4 - by one flank marker only 2312420 rat Pur17 Proteinuria QTL 17 1 7.1 1.0E-4 36105 D1Rat51 33945 D1Mit18 37732 D1Rat208 urine protein amount (VT:0005160) urine total protein excretion rate (CMO:0000756) increased urine protein level anti-basement membrane glomerulonephritis;proteinuria 2312387 19448344 recessive 1 173583273 246119106 1 - by flanking markers 1 159782445 224426393 1 - by flanking markers backcross 61111 1358112 DA/Slc WKY/NCrl 1 167394665 238830534 1 - by flanking markers 1 156677124 218753816 1 - by flanking markers 2312558 rat Glom17 Glomerulus QTL 17 1 3.9 0.001 37834 D1Rat164 39462 D1Rat289 39314 D1Rat216 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 1 184213481 215717121 1 - by flanking markers 1 170218208 201628746 2 - by one flank and peak markers backcross 737905 1331815 LEW/Maas LEW/Mol 1 177235071 208786962 1 - by flanking markers 1 166532971 191278129 1 - by flanking markers 2312560 rat Pur20 Proteinuria QTL 20 6 2.1 0.005 38282 D6Rat79 37076 D6Rat1 37076 D6Rat1 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) cortical renal glomerulopathies;increased urine protein level focal segmental glomerulosclerosis;proteinuria 2312422 18682577 6 139739945 153672040 1 - by flanking markers 6 131029751 144152572 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 6 130561943 144745573 1 - by flanking markers 6 125628133 137801795 1 - by flanking markers 2312562 rat Pur18 Proteinuria QTL 18 5 2.6 0.001 38744 D5Rat116 40256 D5Rat190 40250 D5Rat125 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) cortical renal glomerulopathies;increased urine protein level focal segmental glomerulosclerosis;proteinuria 2312422 18682577 5 1521341 29109277 1 - by flanking markers 5 1220773 24978263 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 5 1525098 33001026 2 - by one flank and peak markers 5 2138965 32656739 2 - by one flank and peak markers 2312564 rat Glom18 Glomerulus QTL 18 1 2.4 0.003 41012 D1Rat287 36950 D1Rat77 37162 D1Rat72 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 1 208389496 259703697 1 - by flanking markers 1 190114247 238037551 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 1 201358068 252480016 1 - by flanking markers 1 185356336 231689108 1 - by flanking markers 2312566 rat Glom20 Glomerulus QTL 20 11 3.6 0.001 36065 D11Rat6 10375 D11Mgh1 38558 D11Rat64 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 11 49765505 89808503 1 - by flanking markers 11 45232526 84560241 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 11 46583209 86714631 1 - by flanking markers 11 44285759 82566702 1 - by flanking markers 2312567 rat Glom19 Glomerulus QTL 19 4 1.9 0.006 41458 D4Rat153 36143 D4Rat60 35325 D4Rat41 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 4 116181405 208908285 2 - by one flank and peak markers 4 43686352 149560340 2 - by one flank and peak markers backcross 737905 1331815 LEW/Maas LEW/Mol 4 49906054 145611886 2 - by one flank and peak markers 4 45456990 146803430 2 - by one flank and peak markers 2312568 rat Glom21 Glomerulus QTL 21 18 2.0 0.005 35511 D18Rat31 37608 D18Rat53 35511 D18Rat31 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) cortical renal glomerulopathies focal segmental glomerulosclerosis 2312422 18682577 18 5401204 41422831 1 - by flanking markers 18 5270273 42006239 1 - by flanking markers backcross 737905 1331815 LEW/Maas LEW/Mol 18 5430134 41781619 1 - by flanking markers 18 5185858 40503530 1 - by flanking markers 2312569 rat Pur19 Proteinuria QTL 19 4 3.4 0.001 41458 D4Rat153 35325 D4Rat41 36870 D4Rat33 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) cortical renal glomerulopathies;increased urine protein level focal segmental glomerulosclerosis;proteinuria 2312422 18682577 4 130537030 162544932 2 - by one flank and peak markers 4 63787419 96623433 2 - by one flank and peak markers backcross 737905 1331815 LEW/Maas LEW/Mol 4 65989243 97759057 2 - by one flank and peak markers 4 65882107 96130297 2 - by one flank and peak markers 2312598 rat Bp340 Blood pressure QTL 340 18 0.05 39518 D18Rat113 40782 D18Rat99 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial diastolic blood pressure;increased systemic arterial systolic blood pressure hypertension 2312571 19620519 18 1 32165443 4 - by one flank marker only 18 1 31654862 4 - by one flank marker only intercross 2312580 SHR.BN-(D18Rat113-D18Rat82)/Ipcv 18 3719547 32487870 1 - by flanking markers 18 1 30558703 4 - by one flank marker only 2312600 rat Bp341 Blood pressure QTL 341 18 0.05 37412 D18Rat40 41356 D18Rat82 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) increased systemic arterial systolic blood pressure hypertension 2312571 19620519 18 60695794 72695235 1 - by flanking markers 18 62106066 73666623 1 - by flanking markers 2312579 SHR.BN-(D18Rat40-D18Rat82)/Ipcv 18 61499531 73016546 1 - by flanking markers 18 59330409 70263868 1 - by flanking markers 2312659 rat Slep7 Serum leptin concentration QTL 7 3 0.001 34228 D3Mgh5 36745 D3Rat1 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 2312642 19584880 61883;61965 Ghrh;Ptpn1 BW17_H (maps to syntenic region);Bw94 (maps to same region);Mlepq1_m (maps to syntenic region) 3 109733850 180128021 1 - by flanking markers 3 97523869 170016653 1 - by flanking markers intercross 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K 3 103141814 176418101 1 - by flanking markers 3 98535255 168026850 1 - by flanking markers 2312660 rat Bw95 Body weight QTL 95 16 0.05 39456 D16Rat88 45369 D16Wox7 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) increased total body fat amount Metabolic Syndrome 2312642 19584880 Insul16 (maps to same region);Slep9 (maps to same region);Stl23 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312662 rat Slep8 Serum leptin concentration QTL 8 10 0.05 34330 D10Mgh2 35665 D10Rat4 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 2312642 19584880 621087 Socs3 Insul15 (maps to same region);Scl65 (maps to same region) 10 60533612 105533612 4 - by one flank marker only 10 106422174 107033716 1 - by flanking markers intercross 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K 10 60875260 105875260 4 - by one flank marker only 10 57134272 102134272 4 - by one flank marker only 2312663 rat Slep9 Serum leptin concentration QTL 9 16 0.001 39456 D16Rat88 45369 D16Wox7 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) increased circulating leptin level Metabolic Syndrome 2312642 19584880 Bw95 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312664 rat Scl62 Serum cholesterol level QTL 62 3 0.05 33782 D3Mit10 37588 D3Rat189 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 3 1 44863303 4 - by one flank marker only 3 1 35797756 4 - by one flank marker only intercross 2312644 DA.WOKW-(D3Mit10-D3Rat189)/K 3 1 39773425 4 - by one flank marker only 3 1 38710544 4 - by one flank marker only 2312666 rat Insul16 Insulin level QTL 16 16 0.01 39456 D16Rat88 45369 D16Wox7 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 2312642 19584880 Bw95 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312668 rat Scl65 Serum cholesterol level QTL 65 10 0.001 34330 D10Mgh2 35665 D10Rat4 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 Slep8 (maps to same region) 10 60533612 105533612 4 - by one flank marker only 10 106422174 107033716 1 - by flanking markers intercross 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K 10 60875260 105875260 4 - by one flank marker only 10 57134272 102134272 4 - by one flank marker only 2312669 rat Stl23 Serum triglyceride level QTL 23 16 0.01 39456 D16Rat88 45369 D16Wox7 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) increased circulating triglyceride level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 Bw95 (maps to same region) 16 1534408 62873174 1 - by flanking markers 16 819225 63306215 1 - by flanking markers intercross 2312645 DA.WOKW-(D16Rat88-D16Wox7)/K 16 1550187 63210301 1 - by flanking markers 16 832236 59492508 1 - by flanking markers 2312670 rat Bw94 Body weight QTL 94 3 0.01 34228 D3Mgh5 36745 D3Rat1 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) increased total body fat amount Metabolic Syndrome 2312642 19584880 61883;61965 Ghrh;Ptpn1 BW17_H (maps to syntenic region);Mlepq1_m (maps to syntenic region);Scl63 (maps to same region);Slep7 (maps to same region) 3 109733850 180128021 1 - by flanking markers 3 97523869 170016653 1 - by flanking markers intercross 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K 3 103141814 176418101 1 - by flanking markers 3 98535255 168026850 1 - by flanking markers 2312671 rat Scl64 Serum cholesterol level QTL 64 5 0.001 34216 D5Mgh6 34041 D5Mit5 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 Mbsyd_m (maps to syntenic region);Scl20 (maps to same region) 5 75334610 112058005 1 - by flanking markers 5 71814715 109163425 1 - by flanking markers intercross 2312646 DA.WOKW-(D5Mgh6-D5Mit5)/K 5 71154828 108092802 1 - by flanking markers 5 68984307 104251008 1 - by flanking markers 2312672 rat Insul15 Insulin level QTL 15 10 0.01 34330 D10Mgh2 35665 D10Rat4 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) increased circulating insulin level Metabolic Syndrome;hyperinsulinism 2312642 19584880 621087 Socs3 Slep8 (maps to same region) 10 60533612 105533612 4 - by one flank marker only 10 106422174 107033716 1 - by flanking markers intercross 2312648 DA.WOKW-(D10Mgh2-D10Rat4)/K 10 60875260 105875260 4 - by one flank marker only 10 57134272 102134272 4 - by one flank marker only 2312673 rat Scl63 Serum cholesterol level QTL 63 3 0.001 34228 D3Mgh5 36745 D3Rat1 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) increased cholesterol level Metabolic Syndrome;familial hyperlipidemia 2312642 19584880 61883;61965 Ghrh;Ptpn1 BW17_H (maps to syntenic region);Bw94 (maps to same region);Mlepq1_m (maps to syntenic region) 3 109733850 180128021 1 - by flanking markers 3 97523869 170016653 1 - by flanking markers intercross 2312647 DA.WOKW-(D3Mgh5-D3Rat1)/K 3 103141814 176418101 1 - by flanking markers 3 98535255 168026850 1 - by flanking markers 2313046 rat Bss78 Bone structure and strength QTL 78 8 3.5 1.0E-4 33559 D8Mit5 34310 D8Mgh4 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss75 (maps to same region);Bss76 (maps to same region);Bss77 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313048 rat Bss84 Bone structure and strength QTL 84 14 3.1 1.0E-4 33692 D14Mit12 60700 D14Mgh11 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss81 (maps to same region);Bss82 (maps to same region);Bss83 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313049 rat Bss72 Bone structure and strength QTL 72 3 2.6 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bmd77 (maps to same region);Bss73 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313051 rat Bss57 Bone structure and strength QTL 57 1 3.7 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313053 rat Bss51 Bone structure and strength QTL 51 1 3.8 1.0E-4 37984 D1Rat232 36640 D1Rat14 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd69 (maps to same region);Bss52 (maps to same region) 1 1 36395668 4 - by one flank marker only 17 1 2481129 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 1 34993530 4 - by one flank marker only 1 1 32356093 4 - by one flank marker only 2313055 rat Bw96 Body weight QTL 96 10 3.6 1.0E-4 33666 D10Mit16 33891 D10Mit5 body mass (VT:0001259) body weight (CMO:0000012) increased bone mineral density osteoporosis 2312767 19113924 Bmd80 (maps to same region) 10 19835926 21392459 1 - by flanking markers 10 20018844 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 19958696 21524070 1 - by flanking markers 10 19606483 64606483 4 - by one flank marker only 2313057 rat Bss76 Bone structure and strength QTL 76 8 3.0 1.0E-4 33559 D8Mit5 34310 D8Mgh4 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss75 (maps to same region);Bss77 (maps to same region);Bss78 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313059 rat Bss55 Bone structure and strength QTL 55 1 3.2 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313060 rat Bss71 Bone structure and strength QTL 71 1 2.6 1.0E-4 34134 D1Mgh1 10878 D12Wox9 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone mineral density;decreased bone strength osteoporosis 2312767 19113924 1 125208389 205564501 1 - by flanking markers 1 119780411 186388966 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 124090312 169090312 4 - by one flank marker only 1 118944747 163944747 4 - by one flank marker only 2313062 rat Bmd73 Bone mineral density QTL 73 1 3.9 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313064 rat Bmd71 Bone mineral density QTL 71 10 0.9 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) decreased bone mineral density osteoporosis 2312767 19113924 Bss61 (maps to same region);Bss62 (maps to same region);Bss63 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313065 rat Bss67 Bone structure and strength QTL 67 1 3.1 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia area (VT:1000281) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313066 rat Bss63 Bone structure and strength QTL 63 10 1.4 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss61 (maps to same region);Bss62 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313067 rat Bss77 Bone structure and strength QTL 77 8 3.1 1.0E-4 33559 D8Mit5 34310 D8Mgh4 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss75 (maps to same region);Bss76 (maps to same region);Bss78 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313069 rat Bss68 Bone structure and strength QTL 68 1 2.9 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia size trait (VT:0100001) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313070 rat Bss52 Bone structure and strength QTL 52 1 4.4 1.0E-4 37984 D1Rat232 36640 D1Rat14 body length (VT:0001256) body length (CMO:0000013) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd69 (maps to same region);Bss51 (maps to same region) 1 1 36395668 4 - by one flank marker only 17 1 2481129 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 1 34993530 4 - by one flank marker only 1 1 32356093 4 - by one flank marker only 2313072 rat Bss53 Bone structure and strength QTL 53 1 4.3 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313073 rat Bmd75 Bone mineral density QTL 75 2 4.1 1.0E-4 36173 D10Rat23 34401 D2Mgh22 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 2 250573351 272824647 1 - by flanking markers 2 224179988 247306073 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 2 231224020 254132424 1 - by flanking markers 2 215377404 237938339 1 - by flanking markers 2313075 rat Bss66 Bone structure and strength QTL 66 1 3.4 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313076 rat Bss74 Bone structure and strength QTL 74 3 2.0 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bmd77 (maps to same region);Bss72 (maps to same region);Bss73 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313077 rat Bss69 Bone structure and strength QTL 69 1 3.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313078 rat Bss54 Bone structure and strength QTL 54 1 3.5 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313079 rat Bss73 Bone structure and strength QTL 73 3 1.5 37010 D3Rat49 11260 D3Mit8 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bmd77 (maps to same region);Bss72 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313080 rat Bss65 Bone structure and strength QTL 65 15 3.9 1.0E-4 42006 D15Arb2 34222 D15Mgh8 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 15 71993218 84794402 1 - by flanking markers 15 67190176 80362100 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 15 68366508 81255430 1 - by flanking markers 15 60990468 73690657 1 - by flanking markers 2313081 rat Bss64 Bone structure and strength QTL 64 10 1.3 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss61 (maps to same region);Bss62 (maps to same region);Bss63 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313082 rat Bss85 Bone structure and strength QTL 85 18 0.8 1.0E-4 34059 D18Mit2 34236 D18Mgh5 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 18 14473035 59473035 4 - by one flank marker only 18 15584909 60584909 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 18 14678852 59678852 4 - by one flank marker only 18 14951337 59951337 4 - by one flank marker only 2313083 rat Bmd74 Bone mineral density QTL 74 1 4.0 1.0E-4 10442 D1Wox16 34134 D1Mgh1 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 1 84871364 127336420 1 - by flanking markers 1 81947770 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 83656882 126240667 1 - by flanking markers 1 82174743 118944897 1 - by flanking markers 2313084 rat Bss83 Bone structure and strength QTL 83 14 2.9 1.0E-4 33692 D14Mit12 60700 D14Mgh11 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss81 (maps to same region);Bss82 (maps to same region);Bss84 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313085 rat Bss59 Bone structure and strength QTL 59 5 2.9 1.0E-4 39686 D5Rat119 34639 D5Pas1 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 5 3239567 30952938 1 - by flanking markers 5 2965857 26938988 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5 3251329 26252076 1 - by flanking markers 5 3844018 26141981 1 - by flanking markers 2313086 rat Bss60 Bone structure and strength QTL 60 8 4.1 1.0E-4 33973 D8Mit2 34310 D8Mgh4 tibia length (VT:0004357) tibia length (CMO:0000450) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 8 52685897 88595536 1 - by flanking markers 8 53049279 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 54065044 89058369 1 - by flanking markers 8 50095249 82460899 1 - by flanking markers 2313087 rat Bmd80 Bone mineral density QTL 80 10 3.2 1.0E-4 33666 D10Mit16 33891 D10Mit5 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 Bw96 (maps to same region) 10 19835926 21392459 1 - by flanking markers 10 20018844 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 19958696 21524070 1 - by flanking markers 10 19606483 64606483 4 - by one flank marker only 2313088 rat Bss75 Bone structure and strength QTL 75 8 3.1 1.0E-4 33559 D8Mit5 34310 D8Mgh4 body length (VT:0001256) body length, nose to rump (CMO:0000079) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss76 (maps to same region);Bss77 (maps to same region);Bss78 (maps to same region) 8 33603024 88595536 1 - by flanking markers 8 32203394 86628010 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 33558660 89058369 1 - by flanking markers 8 30848154 82460899 1 - by flanking markers 2313089 rat Bss81 Bone structure and strength QTL 81 14 3.4 1.0E-4 33692 D14Mit12 60700 D14Mgh11 body length (VT:0001256) body length, nose to rump (CMO:0000079) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss82 (maps to same region);Bss83 (maps to same region);Bss84 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313090 rat Bmd69 Bone mineral density QTL 69 1 4.4 1.0E-4 37984 D1Rat232 36640 D1Rat14 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) decreased bone mineral density osteoporosis 2312767 19113924 Bss51 (maps to same region);Bss52 (maps to same region) 1 1 36395668 4 - by one flank marker only 17 1 2481129 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 1 34993530 4 - by one flank marker only 1 1 32356093 4 - by one flank marker only 2313092 rat Bmd72 Bone mineral density QTL 72 1 2.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region);Bss70 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313093 rat Bmd77 Bone mineral density QTL 77 3 2.2 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) increased bone mineral density osteoporosis 2312767 19113924 Bmd76 (maps to same region);Bss72 (maps to same region);Bss73 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313094 rat Bss58 Bone structure and strength QTL 58 1 3.7 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313095 rat Bss62 Bone structure and strength QTL 62 10 1.5 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss61 (maps to same region);Bss63 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313096 rat Bmd78 Bone mineral density QTL 78 5 3.1 1.0E-4 34136 D5Mgh21 34467 D5Mgh16 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 5 154034053 171522762 1 - by flanking markers 5 151060403 168006088 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5 150360936 167946134 1 - by flanking markers 5 144377876 161317411 1 - by flanking markers 2313097 rat Bss70 Bone structure and strength QTL 70 1 3.5 1.0E-4 36568 D1Rat4 10442 D1Wox16 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) decreased bone mass;decreased bone mineral density;decreased bone strength osteoporosis 2312767 19113924 Bmd72 (maps to same region);Bmd73 (maps to same region);Bss66 (maps to same region);Bss67 (maps to same region);Bss68 (maps to same region);Bss69 (maps to same region) 1 12920106 84871565 1 - by flanking markers 1 11859997 81947972 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 11314489 83657083 1 - by flanking markers 1 11481312 82174945 1 - by flanking markers 2313098 rat Bmd70 Bone mineral density QTL 70 1 3.6 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) decreased bone mineral density osteoporosis 2312767 19113924 Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss56 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313099 rat Bss56 Bone structure and strength QTL 56 1 2.4 1.0E-4 38782 D1Rat136 34134 D1Mgh1 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd70 (maps to same region);Bss53 (maps to same region);Bss54 (maps to same region);Bss55 (maps to same region);Bss57 (maps to same region);Bss58 (maps to same region) 1 44907605 127336420 1 - by flanking markers 1 37646940 119780561 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 43579208 126240667 1 - by flanking markers 1 43284731 118944897 1 - by flanking markers 2313100 rat Bss82 Bone structure and strength QTL 82 14 3.0 1.0E-4 33692 D14Mit12 60700 D14Mgh11 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss81 (maps to same region);Bss83 (maps to same region);Bss84 (maps to same region) 14 40124755 85124755 4 - by one flank marker only 14 40156028 85156028 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 40315610 85315610 4 - by one flank marker only 14 37669719 82669719 4 - by one flank marker only 2313101 rat Bmd76 Bone mineral density QTL 76 3 3.6 1.0E-4 37010 D3Rat49 11260 D3Mit8 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 Bmd77 (maps to same region);Bss72 (maps to same region);Bss73 (maps to same region);Bss74 (maps to same region) 3 33340297 58322647 1 - by flanking markers 3 23762471 47588420 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 28136728 51687917 1 - by flanking markers 3 27494621 50302886 1 - by flanking markers 2313102 rat Bmd79 Bone mineral density QTL 79 7 2.3 1.0E-4 33969 D7Mit4 33816 D7Mit11 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 2312767 19113924 7 104385465 126236887 1 - by flanking markers 7 100273558 123635849 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 7 103815550 126525386 1 - by flanking markers 7 94811085 116738842 1 - by flanking markers 2313103 rat Bss80 Bone structure and strength QTL 80 10 2.0 1.0E-4 34110 D10Mgh13 35254 D10Rat2 tibia strength trait (VT:1000284) tibia midshaft endosteal cross-sectional area (CMO:0001716) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss79 (maps to same region) 11 61504312 87759784 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 65992275 110992275 4 - by one flank marker only 10 62057807 107057807 4 - by one flank marker only 2313104 rat Bss61 Bone structure and strength QTL 61 10 0.9 1.0E-4 33591 D10Mit14 33891 D10Mit5 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bmd71 (maps to same region);Bss62 (maps to same region);Bss63 (maps to same region);Bss64 (maps to same region) 10 4281142 21392459 1 - by flanking markers 10 5339759 21607865 1 - by flanking markers intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 5460119 21524070 1 - by flanking markers 10 5387014 50387014 4 - by one flank marker only 2313105 rat Bss79 Bone structure and strength QTL 79 10 1.8 1.0E-4 34110 D10Mgh13 35254 D10Rat2 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) decreased bone mass;decreased bone strength osteoporosis 2312767 19113924 Bss80 (maps to same region) 11 61504312 87759784 4 - by one flank marker only intercross 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 65992275 110992275 4 - by one flank marker only 10 62057807 107057807 4 - by one flank marker only 2313395 rat Anxrr26 Anxiety related response QTL 26 19 36972 D19Rat21 35028 D19Rat2 36972 D19Rat21 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 19 65454505 68775038 1 - by flanking markers 19 52161990 55455363 1 - by flanking markers intercross 2313384 Wild/Nov 19 54735217 58072143 1 - by flanking markers 19 49976481 53225766 1 - by flanking markers 2313397 rat Coatc1 Coat color QTL1 14 7.0 37624 D14Rat68 coat/hair pigmentation trait (VT:0010463) coat/hair color measurement (CMO:0001808) white spotting 2313383 19363126 additive 14 19985846 64985846 5 - by peak with adj size 14 21150250 66150250 5 - by peak with adj size intercross 2313384 Wild/Nov 14 20189386 65189386 5 - by peak with adj size 14 18541332 63541332 5 - by peak with adj size 2313399 rat Anxrr28 Anxiety related response QTL 28 6 42802 D6Rat229 10777 D6Wox11 42809 D6Rat184 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 6 113838592 147058880 2 - by one flank and peak markers 6 99749898 138261655 1 - by flanking markers intercross 2313384 Wild/Nov 6 104381930 138066274 2 - by one flank and peak markers 6 100671796 132340886 2 - by one flank and peak markers 2313400 rat Anxrr25 Anxiety related response QTL 25 8 2.3 41518 D8Rat135 38140 D8Rat72 35537 D8Rat12 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 8 95458335 121667168 1 - by flanking markers 8 93585899 118725315 1 - by flanking markers intercross 2313384 Wild/Nov 8 95963141 122354314 1 - by flanking markers 8 89265192 114019816 1 - by flanking markers 2313401 rat Anxrr27 Anxiety related response QTL 27 4 11378 D4Wox30 10144 D4Mgh16 11378 D4Wox30 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 4 33498841 61427664 1 - by flanking markers 4 32648616 61646915 1 - by flanking markers intercross 2313384 Wild/Nov 4 33637803 61708341 1 - by flanking markers 4 17933508 62933508 4 - by one flank marker only 2313402 rat Anxrr24 Anxiety related response QTL 24 1 5.1 38426 D1Rat191 33959 D1Mit3 10334 D1Wox14 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) increased aggression towards humans;increased anxiety-related response 2313383 19363126 additive 1 50601416 162692800 1 - by flanking markers 1 43426139 146971983 1 - by flanking markers intercross 2313384 Wild/Nov 1 49147799 156446783 1 - by flanking markers 1 48963584 144267916 1 - by flanking markers 2313854 rat Bp343 Blood pressure QTL 343 17 3.9 33882 D17Mit2 34120 D17Mgh5 2070 Agtr1a life span trait (VT:0005372) age at time of death (CMO:0001193) abnormal induced morbidity/mortality;abnormal pilomotor reflex;increased systemic arterial blood pressure;lethargy;mortality/aging;seizures;weight loss Polyuria;hypertension;malignant hypertension;malignant hypertension;visual epilepsy 619627 10432379 2070 Agtr1a Bp342 (interacts with) 17 35195242 51171794 1 - by flanking markers 17 38353858 59104944 1 - by flanking markers intercross 629501 1298093 SD-Tg(Ren2)27 LEW/NHsd 17 33303627 53475276 1 - by flanking markers 17 31990784 50909196 1 - by flanking markers 2313856 rat Bp342 Blood pressure QTL 342 10 4.4 1.0E-4 11308 D10Wox20 35256 D10Rat11 2493 Ace life span trait (VT:0005372) age at time of death (CMO:0001193) abnormal induced morbidity/mortality;abnormal pilomotor reflex;increased systemic arterial blood pressure;lethargy;mortality/aging;seizures;weight loss Polyuria;hypertension;malignant hypertension;visual epilepsy 2313695;619627 19307186;10432379 2493 Ace Bp343 (interacts with) 10 90085487 99184250 1 - by flanking markers 10 91455572 100633982 1 - by flanking markers intercross 629501 1298093 SD-Tg(Ren2)27 LEW/NHsd 10 90296897 99492409 1 - by flanking markers 10 87307617 96121100 1 - by flanking markers 2314011 rat Gluco56 Glucose level QTL 56 1 35615 D1Rat70 39982 D1Rat323 36580 D1Rat112 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) increased circulating glucose level hyperglycemia 2316693;9587420 20068026;25236446 1311779 Tpcn2 additive 1 224635116 227059170 1 - by flanking markers 1 205040948 207483209 1 - by flanking markers 2314009 NMcwi:HS 1 217776868 220128172 1 - by flanking markers 1 199773958 202166723 1 - by flanking markers 2316649 rat Bp344 Blood pressure QTL 344 1 2315162 D1Mco102 2315160 D1Mco129 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure Hypotension 2312639;9685377 19423552;25231251 1309747;1310046 Ice1;Adamts16 BP47_H (maps to syntenic region);Bp153 (sub_region) 1 36290530 37078065 1 - by flanking markers 17 2374083 3178843 1 - by flanking markers 2316654 2316655 SS.LEW-(D1Mco102-D1Mco129)/1Mco SS.LEW-(D1Mco102-D1Mco129)/2Mco 1 34888392 35680732 1 - by flanking markers 1 32249735 33038814 1 - by flanking markers 2316896 rat Gluco57 Glucose level QTL 57 1 7.2 35945 D1Rat75 10805 D1Mgh13 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 1 256846704 274224361 1 - by flanking markers 1 235098616 252340527 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 1 249607907 266793958 1 - by flanking markers 1 228985440 245907899 1 - by flanking markers 2316947 rat Rf58 Renal function QTL 58 7 7.8 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) kidney failure focal segmental glomerulosclerosis;kidney failure;type 2 diabetes mellitus 2316856 19584172 Pur22 (maps to same region) 7 77892975 123587717 2 - by one flank and peak markers 7 72552109 120746007 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 7 55072862 123602998 1 - by flanking markers 7 68938720 113886318 2 - by one flank and peak markers 2316949 rat Gluco60 Glucose level QTL 60 10 3.7 33585 D10Mit6 35254 D10Rat2 35503 D10Rat20 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 10 14644150 110568670 1 - by flanking markers 10 14721135 110718848 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 10 14827894 110992275 1 - by flanking markers 10 14487011 107057807 1 - by flanking markers 2316950 rat Scl66 Serum cholesterol level QTL 66 8 4.1 34062 D8Mgh2 33559 D8Mit5 35899 D8Rat47 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level familial hyperlipidemia;type 2 diabetes mellitus 2316856 19584172 8 33603128 112967014 1 - by flanking markers 8 32203499 110106272 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 8 33558764 113580387 1 - by flanking markers 8 30848259 105647037 1 - by flanking markers 2316952 rat Pur22 Proteinuria QTL 22 7 5.2 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 urine protein amount (VT:0005160) urine protein level (CMO:0000591) increased urine protein level proteinuria;type 2 diabetes mellitus 2316856 19584172 Rf58 (maps to same region) 7 77892975 123587717 2 - by one flank and peak markers 7 72552109 120746007 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 7 55072862 123602998 1 - by flanking markers 7 68938720 113886318 2 - by one flank and peak markers 2316954 rat Rf57 Renal function QTL 57 5 0.0 33981 D5Mit4 34322 D5Mgh10 34144 D5Mgh11 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) kidney failure focal segmental glomerulosclerosis;kidney failure;type 2 diabetes mellitus 2316856 19584172 5 65595291 97315057 1 - by flanking markers 5 62098775 94515803 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 5 61086653 93273130 1 - by flanking markers 5 59793528 90450144 1 - by flanking markers 2316955 rat Stl24 Serum triglyceride level QTL 24 7 7.1 36422 D7Rat26 10449 D7Mit16 34555 D7Mgh6 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level familial hyperlipidemia;type 2 diabetes mellitus 2316856 19584172 7 77892975 123587717 2 - by one flank and peak markers 7 72552109 120746007 2 - by one flank and peak markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 7 55072862 123602998 1 - by flanking markers 7 68938720 113886318 2 - by one flank and peak markers 2316957 rat Pur21 Proteinuria QTL 21 5 6.2 35306 D5Rat26 34322 D5Mgh10 35144 D5Rat13 urine protein amount (VT:0005160) urine protein level (CMO:0000591) increased urine protein level proteinuria;type 2 diabetes mellitus 2316856 19584172 additive 5 65595291 121495621 1 - by flanking markers 5 62098775 119332868 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 5 61086653 117554114 1 - by flanking markers 5 59793528 113558156 1 - by flanking markers 2316958 rat Gluco58 Glucose level QTL 58 4 10.0 35895 D4Rat1 37340 D4Rat84 35797 D4Rat16 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 4 7858962 246313537 1 - by flanking markers 4 6690606 185398530 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 4 7850904 182171018 1 - by flanking markers 4 11320076 180699135 1 - by flanking markers 2316959 rat Gluco59 Glucose level QTL 59 5 4.7 35306 D5Rat26 11072 D5Mgh2 34144 D5Mgh11 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) increased circulating glucose level hyperglycemia;type 2 diabetes mellitus 2316856 19584172 recessive 5 21842328 121495621 1 - by flanking markers 5 17517235 119332868 1 - by flanking markers intercross 10017 61498 GK/KyoSwe BN/NHsdMcwi 5 35661945 117554267 2 - by one flank and peak markers 5 34944474 113558310 2 - by one flank and peak markers 2317027 rat Aia22 Adjuvant induced arthritis QTL 22 13 2.29 6.1 35975 D13Rat7 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 1 42018230 5 - by peak with adj size 13 1 23584369 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 13 1 36779181 5 - by peak with adj size 13 1 34266636 5 - by peak with adj size 2317029 rat Aia19 Adjuvant induced arthritis QTL 19 10 2.98 8.8 41468 D10Rat155 36319 D10Rat26 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 10 69020437 112200500 4 - by one flank marker only 10 70229781 110718848 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 69385595 112626471 4 - by one flank marker only 10 66978955 107211142 4 - by one flank marker only 2317030 rat Wbc5 White blood cell count QTL 5 8 3.21 0.005 9.0 42244 D8Arb6 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) decreased leukocyte cell number inflammatory bowel disease;leukopenia 2316974 19526527 recessive 8 11490219 56490219 5 - by peak with adj size 8 10116155 55116155 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 11448251 56448251 5 - by peak with adj size 8 8736635 53736635 5 - by peak with adj size 2317032 rat Ginf2 Gastrointestinal inflammation QTL 2 8 3.21 0.005 9.0 41522 D8Rat164 liver integrity trait (VT:0010547) liver granuloma severity score (CMO:0002157) granulomatous inflammation;intestinal inflammation Enterocolitis;inflammatory bowel disease 2316974 19526527 recessive 8 7378774 52378774 5 - by peak with adj size 8 5914098 50914098 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 7368076 52368076 5 - by peak with adj size 8 4705810 49705810 5 - by peak with adj size 2317034 rat Aia9 Adjuvant induced arthritis QTL 9 13 4.62 12.8 35975 D13Rat7 40662 D13Rat113 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19518130 42226993 1 - by flanking markers 13 1084268 33188609 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 13 14279081 37124697 1 - by flanking markers 13 11766535 32331607 1 - by flanking markers 2317035 rat Aia16 Adjuvant induced arthritis QTL 16 7 2.71 9.5 36731 D7Rat24 37374 D7Rat99 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 7 68456672 113456672 4 - by one flank marker only 7 65025373 110025373 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 7 68518460 113518460 4 - by one flank marker only 7 59238038 104238038 4 - by one flank marker only 2317036 rat Livw3 Liver weight QTL 3 8 2.43 0.01 7.1 41522 D8Rat164 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) decreased liver weight inflammatory bowel disease 2316974 19526527 additive 8 7378774 52378774 5 - by peak with adj size 8 5914098 50914098 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 7368076 52368076 5 - by peak with adj size 8 4705810 49705810 5 - by peak with adj size 2317038 rat Ginf3 Gastrointestinal inflammation QTL 3 17 2.89 0.005 8.4 37926 D17Rat62 liver integrity trait (VT:0010547) liver granuloma severity score (CMO:0002157) granulomatous inflammation;intestinal inflammation Enterocolitis;inflammatory bowel disease 2316974 19526527 dominant 17 55528137 92503511 5 - by peak with adj size 17 60979997 97296363 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 17 53871488 90843779 5 - by peak with adj size 17 49920154 86533673 5 - by peak with adj size 2317039 rat Aia6 Adjuvant induced arthritis QTL 6 10 4.31 13.8 41468 D10Rat155 36319 D10Rat26 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 recessive 10 69020437 112200500 4 - by one flank marker only 10 70229781 110718848 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 69385595 112626471 4 - by one flank marker only 10 66978955 107211142 4 - by one flank marker only 2317040 rat Aia21 Adjuvant induced arthritis QTL 21 13 2.75 7.3 40662 D13Rat113 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19726927 64726927 5 - by peak with adj size 13 10688543 55688543 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 13 14624631 59624631 5 - by peak with adj size 13 9831541 54831541 5 - by peak with adj size 2317041 rat Aia14 Adjuvant induced arthritis QTL 14 2 3.29 8.6 36093 D2Rat26 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 additive 2 91248901 136248901 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 2 71495404 116495404 5 - by peak with adj size 2317042 rat Aia20 Adjuvant induced arthritis QTL 20 10 3.38 12.0 36319 D10Rat26 34274 D10Mgh5 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 10 40302564 85302564 4 - by one flank marker only 10 41317054 86317054 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 40514044 85514044 4 - by one flank marker only 10 37565079 82565079 4 - by one flank marker only 2317043 rat Aia7 Adjuvant induced arthritis QTL 7 10 3.82 12.6 36319 D10Rat26 34274 D10Mgh5 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 10 40302564 85302564 4 - by one flank marker only 10 41317054 86317054 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 10 40514044 85514044 4 - by one flank marker only 10 37565079 82565079 4 - by one flank marker only 2317044 rat Aia23 Adjuvant induced arthritis QTL 23 13 2.3 6.5 35975 D13Rat7 40662 D13Rat113 joint integrity trait (VT:0010548) ankle joint diameter (CMO:0002148) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19518130 42226993 1 - by flanking markers 13 1084268 33188609 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 13 14279081 37124697 1 - by flanking markers 13 11766535 32331607 1 - by flanking markers 2317045 rat Aia11 Adjuvant induced arthritis QTL 11 17 4.06 11.5 35585 D17Rat151 39044 D17Rat89 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 17 65440692 71966023 1 - by flanking markers 17 71569891 77806121 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 17 63675975 70261772 1 - by flanking markers 17 60781426 86533673 4 - by one flank marker only 2317046 rat Aia8 Adjuvant induced arthritis QTL 8 13 3.9700000286102295 10.399999618530273 40662 D13Rat113 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 13 19726927 64726927 5 - by peak with adj size 13 10688543 55688543 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 13 14624631 59624631 5 - by peak with adj size 13 9831541 54831541 5 - by peak with adj size 2317047 rat Wbc4 White blood cell count QTL 4 7 0.01 38322 D7Rat63 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) decreased leukocyte cell number inflammatory bowel disease;leukopenia 2316974 19526527 7 1 38285714 5 - by peak with adj size 7 1 36741943 5 - by peak with adj size 737926 737932 F344/NCrl LEW/Crl 7 1 38119654 5 - by peak with adj size 7 1 35342956 5 - by peak with adj size 2317048 rat Ginf1 Gastrointestinal inflammation QTL 1 8 3.52 0.005 10.2 41522 D8Rat164 cecum mucosa thickness (VT:0010234) enterocolitis severity score (CMO:0002138) granulomatous inflammation;intestinal inflammation Enterocolitis;inflammatory bowel disease 2316974 19526527 recessive 8 7378774 52378774 5 - by peak with adj size 8 5914098 50914098 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 7368076 52368076 5 - by peak with adj size 8 4705810 49705810 5 - by peak with adj size 2317050 rat Aia24 Adjuvant induced arthritis QTL 24 15 2.06 7.5 41636 D15Rat123 34222 D15Mgh8 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 15 63333669 84794402 1 - by flanking markers 15 58412001 80362100 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 15 59651151 81255430 1 - by flanking markers 15 52847908 73690657 1 - by flanking markers 2317051 rat Aia18 Adjuvant induced arthritis QTL 18 8 2.42 10.3 42244 D8Arb6 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 8 11490219 56490219 5 - by peak with adj size 8 10116155 55116155 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 8 11448251 56448251 5 - by peak with adj size 8 8736635 53736635 5 - by peak with adj size 2317052 rat Aia17 Adjuvant induced arthritis QTL 17 7 2.13 5.7 37374 D7Rat99 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 7 90956573 135956573 5 - by peak with adj size 7 87525274 132525274 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 7 91018361 136018361 5 - by peak with adj size 7 81737938 126737938 5 - by peak with adj size 2317053 rat Aia25 Adjuvant induced arthritis QTL 25 17 2.69 7.9 35585 D17Rat151 34120 D17Mgh5 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 17 51171794 65440692 1 - by flanking markers 17 59104944 71569891 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 17 53475276 63675975 1 - by flanking markers 17 50909196 60781426 1 - by flanking markers 2317054 rat Aia12 Adjuvant induced arthritis QTL 12 17 4.24 11.0 35585 D17Rat151 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 17 42940774 87940774 5 - by peak with adj size 17 49069974 94069974 5 - by peak with adj size 737926 737932 F344/NCrl LEW/Crl 17 41176057 86176057 5 - by peak with adj size 17 38281509 83281509 5 - by peak with adj size 2317055 rat Aia10 Adjuvant induced arthritis QTL 10 15 3.41 8.9 40516 D15Rat106 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 recessive 15 87444850 114627140 5 - by peak with adj size 15 83677810 109758846 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 15 84050550 111246239 5 - by peak with adj size 15 75788062 101769107 5 - by peak with adj size 2317056 rat Wbc3 White blood cell count QTL 3 5 2.51 0.01 36187 D5Rat30 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) decreased leukocyte cell number inflammatory bowel disease;leukopenia 2316974 19526527 recessive 5 115070246 160070246 5 - by peak with adj size 5 112840801 157840801 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 5 111278451 156278451 5 - by peak with adj size 5 105999803 150999803 5 - by peak with adj size 2317057 rat Aia27 Adjuvant induced arthritis QTL 27 20 2.83 13.7 41562 D20Rat46 37888 D20Rat34 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 20 5499214 29787701 1 - by flanking markers 20 3039759 37383914 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 20 3402111 27968216 1 - by flanking markers 20 2892597 26381954 1 - by flanking markers 2317058 rat Aia13 Adjuvant induced arthritis QTL 13 2 2.9 8.1 33620 D2Mit6 37664 D2Rat167 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 recessive 2 98037122 99636963 1 - by flanking markers 2 77630629 79118861 1 - by flanking markers intercross 737926 737932 F344/NCrl LEW/Crl 2 78321410 79969856 1 - by flanking markers 2 76539322 77991361 1 - by flanking markers 2317059 rat Aia15 Adjuvant induced arthritis QTL 15 7 2.46 7.4 36422 D7Rat26 34999 D7Rat44 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 dominant 7 24590450 69590450 4 - by one flank marker only 7 21202126 66202126 4 - by one flank marker only intercross 737926 737932 F344/NCrl LEW/Crl 7 55072862 69399731 1 - by flanking markers 7 17004598 62004598 4 - by one flank marker only 2317060 rat Aia26 Adjuvant induced arthritis QTL 26 17 3.22 8.4 35585 D17Rat151 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) joint inflammation inflammatory bowel disease;rheumatoid arthritis 2316974 19526527 17 42940774 87940774 5 - by peak with adj size 17 49069974 94069974 5 - by peak with adj size intercross 737926 737932 F344/NCrl LEW/Crl 17 41176057 86176057 5 - by peak with adj size 17 38281509 83281509 5 - by peak with adj size 2317577 rat Eae24 Experimental allergic encephalomyelitis QTL 24 4 37012 D4Rat25 60806 D4Wox7 36181 D4Rat26 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419);percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047);post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) CNS inflammation Experimental Autoimmune Encephalomyelitis 2317591;2317711 19675581 4 65802990 138066698 1 - by flanking markers 4 65821936 71729738 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 65987814 73372824 1 - by flanking markers 4 66993185 72752834 1 - by flanking markers 2317586 rat Eae25 Experimental allergic encephalomyelitis QTL 25 4 9.300000190734863 11009 D4Wox21 42705 D4Rat265 43816 D4Got64 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis duration (CMO:0001424);experimental autoimmune encephalomyelitis severity score (CMO:0001419);percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047);post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) CNS inflammation;weight loss Experimental Autoimmune Encephalomyelitis 2317591;2317711 19675581 4 144235277 148715224 1 - by flanking markers 4 78039509 82266081 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 79559380 84053053 1 - by flanking markers 4 78882817 83007655 1 - by flanking markers 2317587 rat Eae26 Experimental allergic encephalomyelitis QTL 26 4 40586 D4Rat231 10560 D4Mit12 36462 D4Rat36 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation;weight loss Experimental Autoimmune Encephalomyelitis 2317711;2317591 19675581 4 154593964 163844298 1 - by flanking markers 4 88462327 104416171 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 89777552 99067150 1 - by flanking markers 4 88656681 103194984 1 - by flanking markers 2317588 rat Eae27 Experimental allergic encephalomyelitis QTL 27 4 10560 D4Mit12 39990 D4Rat177 40014 D4Rat233 nervous system integrity trait (VT:0010566) percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047) CNS inflammation Experimental Autoimmune Encephalomyelitis 2317711;2317591 19675581 4 163844120 175325053 1 - by flanking markers 4 104415992 114074165 1 - by flanking markers 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 99066972 110635449 1 - by flanking markers 4 103194805 112478794 1 - by flanking markers 2317750 rat Glom26 Glomerulus QTL 26 15 4.3 38200 D15Rat54 41010 D15Rat96 41564 D15Rat80 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 15 19494318 76140870 1 - by flanking markers 15 14072029 71533203 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 15 15492360 72568189 1 - by flanking markers 15 12496141 65205939 1 - by flanking markers 2317752 rat Glom23 Glomerulus QTL 23 2 3.6 40892 D2Rat234 35340 D2Rat70 38054 D2Rat138 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 2 228015546 281850471 1 - by flanking markers 2 201223893 254933362 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 2 208594330 263179188 1 - by flanking markers 2 193452645 245889826 1 - by flanking markers 2317753 rat Glom24 Glomerulus QTL 24 5 3.1 35352 D5Rat33 35771 D5Rat22 35771 D5Rat22 kidney glomerulus integrity trait (VT:0010546) kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 5 105287339 145698175 1 - by flanking markers 5 102024381 143540180 1 - by flanking markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 5 101265591 141912026 1 - by flanking markers 5 97570330 136479578 1 - by flanking markers 2317754 rat Glom25 Glomerulus QTL 25 10 3.5 41478 D10Rat186 38514 D10Rat105 38514 D10Rat105 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 10 86167133 112200500 5 - by peak with adj size 10 86810917 110718848 5 - by peak with adj size intercross 1298093 1358112 LEW/NHsd WKY/NCrl 10 86566908 112626471 5 - by peak with adj size 10 82685200 107211142 5 - by peak with adj size 2317755 rat Glom22 Glomerulus QTL 22 1 3.8 36640 D1Rat14 36568 D1Rat4 39666 D1Rat246 urine protein amount (VT:0005160) urine protein level (CMO:0000591) glomerulonephritis glomerulonephritis;nephritis 2293335;7207868 16482158 1 12920275 36395486 1 - by flanking markers 1 1 11860328 2 - by one flank and peak markers intercross 1298093 1358112 LEW/NHsd WKY/NCrl 1 11314658 34993348 1 - by flanking markers 1 11481482 32355910 1 - by flanking markers 2317833 rat Alcrsp19 Alcohol response QTL 19 1 12.4 0.001 36432 D1Rat35 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 2317807;1334439 19500156;15608595 Alcrsp1 (sub_region) 1 109458992 154458992 5 - by peak with adj size 1 102248992 147248992 5 - by peak with adj size intercross 1578694 1578715 AT ANT 1 108417193 153417193 5 - by peak with adj size 1 100979852 145979852 5 - by peak with adj size 2317840 rat Alcrsp20 Alcohol response QTL 20 6 2.4000000953674316 0.63 37718 D6Rat90 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 intercross intercross 1578694 1578715 AT ANT 2317848 rat Alcrsp21 Alcohol response QTL 21 19 1.899999976158142 0.05 35376 D19Rat12 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 19 12034075 57034075 5 - by peak with adj size 19 4997213 49997213 5 - by peak with adj size intercross intercross 1578694 1578715 AT ANT 19 1044648 46044648 5 - by peak with adj size 19 3204777 48204777 5 - by peak with adj size 2317851 rat Alcrsp22 Alcohol response QTL 22 20 3.2 0.05 38324 D20Rat32 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 2317807 19500156 20 1 28385430 5 - by peak with adj size 20 1 27477794 5 - by peak with adj size intercoss 1578694 1578715 AT ANT 20 1 26305996 5 - by peak with adj size 20 1 27339237 5 - by peak with adj size 2317879 rat Alcrsp27 Alcohol response QTL 27 14 3.3 0.63 40342 D14Rat92 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference;impaired righting response Ataxia;alcohol-induced mental disorder 2317807 19500156 14 62674474 107674474 5 - by peak with adj size 14 62384564 107384564 5 - by peak with adj size intercross 1578694 1578715 AT ANT 14 61993178 106993178 5 - by peak with adj size 14 56631369 101631369 5 - by peak with adj size 2317880 rat Alcrsp25 Alcohol response QTL 25 20 2.3 37446 D20Rat54 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 20 19560735 57791882 5 - by peak with adj size 20 18303073 55268282 5 - by peak with adj size intercross 1578694 1578715 AT ANT 20 17827096 56205956 5 - by peak with adj size 20 17697550 54435887 5 - by peak with adj size 2317882 rat Alcrsp24 Alcohol response QTL 24 8 3.2 0.05 36039 D8Rat58 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 8 1 25960178 5 - by peak with adj size 8 1 25539735 5 - by peak with adj size intercross 1578694 1578715 AT ANT 8 1 25942267 5 - by peak with adj size 8 1 25902202 5 - by peak with adj size 2317883 rat Alcrsp26 Alcohol response QTL 26 3 1.8 0.63 36745 D3Rat1 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 3 157627942 183740530 5 - by peak with adj size 3 147516452 171063335 5 - by peak with adj size intercross 1578694 1578715 AT ANT 3 153918022 177699992 5 - by peak with adj size 3 145526770 169034231 5 - by peak with adj size 2317885 rat Alcrsp28 Alcohol response QTL 28 2 2.1 0.63 36574 D2Rat68 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 2 248320486 285068071 5 - by peak with adj size 2 222136025 258207540 5 - by peak with adj size intercross 1578694 1578715 AT ANT 2 229793522 266435125 5 - by peak with adj size 2 212828222 249053267 5 - by peak with adj size 2317886 rat Alcrsp23 Alcohol response QTL 23 2 2.4 0.63 42596 D2Rat339 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) abnormal motor coordination/balance;alcohol preference Ataxia;alcohol-induced mental disorder 2317807 19500156 intercross 1578694 1578715 AT ANT 2 96844330 141844330 5 - by peak with adj size 2324617 rat Coatc2 Coat color QTL 2 14 0.001 90.0 38932 D14Rat36 36287 D14Rat12 45176 D14Got40 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810) abnormal coat/hair pigmentation 2317982 20364790 recessive Coatc4 (interacts with) 14 32833464 61886417 1 - by flanking markers 14 33039698 41707592 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 14 33039912 61783215 1 - by flanking markers 14 30767025 39153750 1 - by flanking markers 2324619 rat Coatc4 Coat color QTL 4 17 0.001 18.0 35176 D17Rat2 38772 D17Rat102 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810);pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811) abnormal coat/hair pigmentation 2317982 20364790 Coatc2 (interacts with) 17 5553716 25980421 1 - by flanking markers 17 9988620 27118575 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 17 3336972 24030841 1 - by flanking markers 17 4299130 21293263 1 - by flanking markers 2324620 rat Coatc3 Coat color QTL 3 15 7.0 36313 D15Rat5 35611 D15Rat11 35120 D15Rat6 coat/hair pigmentation trait (VT:0010463) pigmented coat/hair area to total coat/hair area ratio (CMO:0001810) abnormal coat/hair pigmentation 2317982 20364790 15 24970714 56554042 1 - by flanking markers 15 22452603 51526246 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 15 21021342 52831189 1 - by flanking markers 15 19856566 46187442 1 - by flanking markers 2324621 rat Coatc5 Coat color QTL 5 17 9.0 36225 D17Rat15 35687 D17Rat47 10349 D17Arb7 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) abnormal coat/hair pigmentation 2317982 20364790 17 33949701 79573336 1 - by flanking markers 17 37727971 85072478 1 - by flanking markers intercross 1302631 1302729 BN/SsNSlc LEA/Tj 17 32055882 77922655 1 - by flanking markers 17 31368391 73951021 1 - by flanking markers 2325725 rat Eae31 Experimental allergic encephalomyelitis QTL 31 1 39006 D1Rat193 35851 D1Rat68 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2324646;6892695 20072140;20072140 2899;1304950 Il4r;Il21r 1 201022827 212591221 1 - by flanking markers 1 183163129 193070197 1 - by flanking markers intercross 2298494 2306784 Kini:DA,PVG-G10 Kini:DA,PVG-G12 1 193968438 205603226 1 - by flanking markers 1 178810256 188377506 1 - by flanking markers 2325726 rat Eae30 Experimental allergic encephalomyelitis QTL 30 1 39316 D1Rat217 40922 D1Rat270 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2324646;6892695 20072140;20072140 1311983 Rgma 1 131506554 136616701 1 - by flanking markers 1 124308081 130290315 1 - by flanking markers intercross 2298494 2306784 Kini:DA,PVG-G10 Kini:DA,PVG-G12 1 130458716 135612014 1 - by flanking markers 1 123053310 128593844 1 - by flanking markers 2325727 rat Pia41 Pristane induced arthritis QTL 41 1 39006 D1Rat193 1629174 D1Got334 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) CNS inflammation;increased susceptibility to induced arthritis;joint swelling Experimental Arthritis;multiple sclerosis;rheumatoid arthritis 2324646;6892695 20072140;20072140 2899;1304950 Il4r;Il21r 1 201022827 204626168 1 - by flanking markers 1 183163129 185328208 1 - by flanking markers 2298494 2306784 Kini:DA,PVG-G10 Kini:DA,PVG-G12 1 193968438 197643128 1 - by flanking markers 1 178810256 180814005 1 - by flanking markers 2325836 rat Bp346 Blood pressure QTL 346 10 0.001 44781 D10Got112 2875 Igfbp4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185;6480214;7421500 18806617;22124177;23814039 2323022 Tom1l3 Bp258 (interacts with);Bp279 (interacts with);Bp310 (interacts with) 10 78816241 86759484 1 - by flanking markers 10 79857808 87834315 1 - by flanking markers 2325798 SS.LEW-(D10Got112-Igfbp4)/Ayd 10 78970279 86962563 1 - by flanking markers 10 76246085 84007272 1 - by flanking markers 2325838 rat Bp347 Blood pressure QTL 347 16 0.001 1358050 D16Chm48 1358041 D16Chm60 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185;7421500;11573640 18806617;23814039;27391979 1595469 Tasor Bp279 (interacts with);Bp310 (interacts with);Bp318 (interacts with) 16 2471921 3491557 1 - by flanking markers 16 2116303 3165043 1 - by flanking markers 2325801 2325803 SS.LEW-(D16Chm36-D16Mit2)/Ayd SS.LEW-(D16Rat112-D16Chm60)/Ayd 16 1 3525217 4 - by one flank marker only 16 1 3080679 4 - by one flank marker only 2325839 rat Bp348 Blood pressure QTL 348 18 0.001 1579149 D18Chm3 1579055 D18Chm52 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185 18806617 18 26454805 43276109 1 - by flanking markers 18 26435325 44551526 1 - by flanking markers 2301381 2301385 SS.LEW-(D18Chm41-D18Rat92)/Ayd SS.LEW-(D18Rat29-D18Rat55)/Ayd 18 26743404 43659626 1 - by flanking markers 18 25570985 70570985 4 - by one flank marker only 2325840 rat Bp345 Blood pressure QTL 345 3 0.001 10260 D3Rat52 728024 D3Chm57 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 2301185;7421500;9685142 18806617;23814039;25380161 Bp256 (interacts with);Bp310 (interacts with) 3 19410399 34290625 1 - by flanking markers 3 14051872 24716931 1 - by flanking markers 2325796 SS.LEW-(D3Rat52-D3Chm57)/Ayd 3 14090411 29084626 1 - by flanking markers 3 18311454 28441896 1 - by flanking markers 4145117 rat Mcs27 Mammary carcinoma susceptibility QTL 27 13 1.0E-4 41346 D13Rat123 37314 D13Rat101 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 4143380 20737482 Mcs26 (maps to same region) 13 53846466 58314767 1 - by flanking markers 13 44872181 49428577 1 - by flanking markers intercross 2293145 SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi 13 48776655 53264877 1 - by flanking markers 13 43437904 47841255 1 - by flanking markers 4145118 rat Mcs26 Mammary carcinoma susceptibility QTL 26 6 1.0E-4 40144 D6Rat119 42200 D6Arb3 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 4143380 20737482 Mcs27 (maps to same region) 6 120420333 147057860 1 - by flanking markers 6 111239053 138260635 1 - by flanking markers intercross 4145088 SS.BN-(D6Rat119-D6Arb3)/Mcwi 6 111134524 138065254 1 - by flanking markers 6 106752656 132339866 1 - by flanking markers 4145119 rat Mcs25 Mammary carcinoma susceptibility QTL 25 6 1.0E-4 39716 D6Rat149 35198 D6Rat11 mammary gland integrity trait (VT:0010552) ratio of deaths to total study population during a period of time (CMO:0001023) Drug-Related Side Effects and Adverse Reactions 4143380 20737482 6 6959479 124634525 1 - by flanking markers 6 7161389 115238799 1 - by flanking markers intercross 4145090 4145091 SS.BN-(D6Rat149-D6Got171)/Mcwi SS.BN-(D6Rat149-D6Arb3)/Mcwi 6 7009971 115379601 1 - by flanking markers 6 10894415 110548006 1 - by flanking markers 4889419 rat Cstrr2 Cold stress response QTL 2 1 0.05 38112 D1Rat171 60203 D1Got154 urine catecholamine amount (VT:0010502) absolute change in urine norepinephrine level (CMO:0001634) abnormal response of heart to induced stress;increased urine noradrenaline level autonomic nervous system disease;hypertension 4889147 21063213 Stresp24 (maps to same region) 1 172767534 175466596 1 - by flanking markers 1 158964262 161961786 1 - by flanking markers 4889411 SHRSP.WKY-(D1Smu13-D1Wox33)/Izm 1 166577232 169318847 1 - by flanking markers 1 155866514 158592016 1 - by flanking markers 4889428 rat Stresp24 Stress response QTL 24 1 0.05 38112 D1Rat171 11019 D1Wox33 heart pumping trait (VT:2000009) absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162) abnormal sensory capabilities/reflexes/nociception;increased circulating noradrenaline level autonomic nervous system disease;hypertension 4889147 21063213 Cstrr2 (maps to same region) 1 172767534 174300801 1 - by flanking markers 1 158964262 160755065 1 - by flanking markers 4889414 WKY.SHRSP-(D1Rat171-D1Wox33)/Izm 1 166577232 211577232 4 - by one flank marker only 1 155866514 200866514 4 - by one flank marker only 4889451 rat Eae29 Experimental allergic encephalomyelitis QTL 29 1 5.51 39234 D1Rat248 35685 D1Rat10 43193 D1Got11 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 2317711;4888518 21041731 1303169 Il22ra2 1 7306802 86917075 1 - by flanking markers 1 6253932 25271177 1 - by flanking markers 4889450 DA.PVG.1AV1-(D1Rat248-D1Rat10)/Kini 1 5655772 85706974 1 - by flanking markers 1 5925877 24697545 1 - by flanking markers 4889492 rat Pancm2 Pancreatic morphology QTL 2 10 3.2 44840 D10Got156 pancreatic beta cell morphology trait (VT:0005217) ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814) decreased pancreatic beta cell mass type 2 diabetes mellitus 4889455 20878524 10 79903416 112200500 5 - by peak with adj size 10 81350126 110718848 5 - by peak with adj size intercross 737972 4889464 BN/Crl GK/Ox 10 80239190 112626471 5 - by peak with adj size 10 76748906 107211142 5 - by peak with adj size 4889494 rat Scort2 Serum corticosterone level QTL 2 1 4.2 1634688 D1Got308 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) decreased circulating corticosterone level type 2 diabetes mellitus 4889455 20878524 1 87808001 132808001 5 - by peak with adj size 1 80851478 125851478 5 - by peak with adj size intercross 737972 4889464 BN/Crl GK/Ox 1 86776571 131776571 5 - by peak with adj size 1 80592172 125592172 5 - by peak with adj size 4889511 rat Gluco61 Glucose level QTL 61 4 4.7 0.001 39194 D4Rat115 41888 D4Rat282 43767 D4Got15 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) decreased circulating insulin level;decreased pancreas weight;increased circulating glucose level Experimental Diabetes Mellitus 2326163 20530722 621465;1584719 Ica1;Ndufa4 Gluco32 (maps to same region) 4 34996009 38909359 1 - by flanking markers 4 34206019 38029988 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 4 35138860 39073276 1 - by flanking markers 4 37177950 40869000 1 - by flanking markers 4889521 rat Gluco62 Glucose level QTL 62 11 2.82 0.001 40158 D11Rat65 39356 D11Rat41 35955 D11Rat38 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) decreased circulating insulin level;decreased pancreas weight;increased circulating glucose level Experimental Diabetes Mellitus 2326163 20530722 11 64210638 90233310 1 - by flanking markers 11 56625258 67465962 2 - by one flank and peak markers 1357181 1357191 CDR/Ygl CDS/Ygl 11 60109842 87141948 1 - by flanking markers 11 55136729 82993457 1 - by flanking markers 4889606 rat Gluco63 Glucose level QTL 63 13 2.86 0.003 37554 D13Rat57 34124 D13Mgh6 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) decreased circulating insulin level;decreased pancreas weight;increased circulating glucose level Experimental Diabetes Mellitus 2326163 20530722 13 91468337 118718031 2 - by one flank and peak markers 13 84280242 111154910 2 - by one flank and peak markers 1357181 1357191 CDR/Ygl CDS/Ygl 13 86833393 114033958 2 - by one flank and peak markers 13 80753256 106807694 2 - by one flank and peak markers 4889610 rat Pancm3 Pancreatic morphology QTL 3 20 3.75 0.001 35657 D20Rat5 37792 D20Rat29 37652 D20Rat26 pancreas mass (VT:0010144) pancreas wet weight (CMO:0000626) increased pancreas weight Experimental Diabetes Mellitus 2326163 20530722 20 21025611 50747478 1 - by flanking markers 20 18411845 48055886 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 20 18872150 49108956 1 - by flanking markers 20 17617832 47606836 1 - by flanking markers 4889834 rat Pur24 Proteinuria QTL 24 2 5.8 0.014 34234 D2Mgh9 34461 D2Mgh12 10712 D2Mgh10 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 2 218191291 235592880 1 - by flanking markers 2 191378142 210636169 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 2 198704357 217498710 1 - by flanking markers 2 184114274 202447032 1 - by flanking markers 4889848 rat Pur25 Proteinuria QTL 25 6 14.0 0.003 36452 D6Rat25 40588 D6Rat165 34306 D6Mgh5 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 6 69405371 103458909 2 - by one flank and peak markers 6 58941174 93819252 2 - by one flank and peak markers 631572 631573 SBH/Ygl SBN/Ygl 6 59803065 94001333 2 - by one flank and peak markers 6 56728562 90198260 2 - by one flank and peak markers 4889852 rat Pur26 Proteinuria QTL 26 9 15.0 0.001 33999 D9Mit5 40510 D9Rat109 34088 D9Mgh2 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 9 89765913 106780702 1 - by flanking markers 9 75633467 100495220 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 9 90024661 107199079 1 - by flanking markers 9 77813894 101597663 1 - by flanking markers 4889857 rat Pur27 Proteinuria QTL 27 20 12.2 0.001 37594 D20Rat41 35657 D20Rat5 38324 D20Rat32 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 2231;3426;69418;628596 C2;Psmb8;Ubd;Tubb5 recessive 20 6118659 21025734 1 - by flanking markers 20 4740609 18411969 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 20 4039113 18872273 1 - by flanking markers 20 4606607 17617956 1 - by flanking markers 4889859 rat Pur28 Proteinuria QTL 28 11 19.5 0.001 36095 D11Rat7 34118 D11Mgh2 35955 D11Rat38 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 11 51082377 81545905 2 - by one flank and peak markers 11 46499941 77591279 2 - by one flank and peak markers 631572 631573 SBH/Ygl SBN/Ygl 11 47901049 78471527 2 - by one flank and peak markers 11 45459323 75190161 2 - by one flank and peak markers 4889861 rat Pur29 Proteinuria QTL 29 13 13.8 0.005 34351 D13Mgh4 37554 D13Rat57 37844 D13Rat85 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 recessive 13 47416073 91468484 1 - by flanking markers 13 38489801 84280390 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 13 42310744 86833540 1 - by flanking markers 13 37415584 80753406 1 - by flanking markers 4889870 rat Pur30 Proteinuria QTL 30 20 19.0 0.005 37632 D20Rat49 39998 D20Rat64 43144 D20Rat67 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) increased urine protein level proteinuria 4889613 20876844 2231;3426;69418;628596 C2;Psmb8;Ubd;Tubb5 recessive 20 10844023 32781021 1 - by flanking markers 20 8286533 28734502 1 - by flanking markers 631572 631573 SBH/Ygl SBN/Ygl 20 8654341 30991290 1 - by flanking markers 20 8042410 29322208 1 - by flanking markers 4889891 rat Eae32 Experimental allergic encephalomyelitis QTL 32 17 4.8 2.0E-4 34827 D17Rat12 45464 D17Got49 45469 D17Got45 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 4889889;629629 20856809;12517974 1306984 Btn1a1 17 29605177 39973813 1 - by flanking markers 17 33277173 42659723 1 - by flanking markers 2298494 Kini:DA,PVG-G10 17 27690959 38110914 1 - by flanking markers 17 27027949 36146731 1 - by flanking markers 4889894 rat Eae33 Experimental allergic encephalomyelitis QTL 33 17 5.2 1.0E-4 34120 D17Mgh5 38092 D17Rat95 60143 D17Got120 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) CNS inflammation Experimental Autoimmune Encephalomyelitis;multiple sclerosis 4889889;629629 20856809;12517974 3831 Zeb1 17 51171698 92351300 1 - by flanking markers 17 59104847 66993271 1 - by flanking markers 2298494 4889890 Kini:DA,PVG-G10 DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini 17 53475180 90690466 1 - by flanking markers 17 50909099 86022412 1 - by flanking markers 4889919 rat Bss86 Bone structure and strength QTL 86 1 4.1 36610 D1Rat20 10442 D1Wox16 tibia area (VT:1000281) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone strength osteoporosis 4889918 20699128 1 55091281 84871565 1 - by flanking markers 1 48777689 81947972 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 53851348 83657083 1 - by flanking markers 1 53895117 82174945 1 - by flanking markers 4889929 rat Bss87 Bone structure and strength QTL 87 1 6.7 36610 D1Rat20 10442 D1Wox16 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) decreased bone strength osteoporosis 4889918 20699128 1 55091281 84871565 1 - by flanking markers 1 48777689 81947972 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 53851348 83657083 1 - by flanking markers 1 53895117 82174945 1 - by flanking markers 4889933 rat Bss88 Bone structure and strength QTL 88 6 3.8 34184 D6Mgh11 33897 D3Mit19 tibia size trait (VT:0100001) tibia total bone volume (CMO:0001724) decreased bone strength osteoporosis 4889918 20699128 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4889938 rat Bss89 Bone structure and strength QTL 89 8 3.8 33973 D8Mit2 34310 D8Mgh4 tibia size trait (VT:0100001) tibia cortical bone volume (CMO:0001725) decreased bone strength osteoporosis 4889918 20699128 8 52685897 88595536 1 - by flanking markers 8 53049279 86628010 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 54065044 89058369 1 - by flanking markers 8 50095249 82460899 1 - by flanking markers 4889943 rat Bss90 Bone structure and strength QTL 90 9 4.1 34088 D9Mgh2 36908 D9Rat4 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) decreased bone strength osteoporosis 4889918 20699128 9 92471883 98282881 1 - by flanking markers 9 84432884 90697021 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 9 92741297 98606834 1 - by flanking markers 9 86369631 92058970 1 - by flanking markers 4889948 rat Bss91 Bone structure and strength QTL 91 10 4.0 34274 D10Mgh5 34485 D10Mgh4 tibia area (VT:1000281) tibia midshaft total cross-sectional area (CMO:0001715) decreased bone strength osteoporosis 4889918 20699128 10 85302342 95372987 1 - by flanking markers 10 86316831 96799937 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 10 85513822 95638337 1 - by flanking markers 10 82564856 92369470 1 - by flanking markers 4889951 rat Bss92 Bone structure and strength QTL 92 14 3.9 10773 D14Mit10 35897 D14Rat22 tibia area (VT:1000281) tibia-fibula cortical bone total cross-sectional area (CMO:0001721) decreased bone strength osteoporosis 4889918 20699128 14 81093112 106705037 1 - by flanking markers 14 87960277 102509397 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 14 87458772 106641756 1 - by flanking markers 14 82057471 95876975 1 - by flanking markers 4889955 rat Bss93 Bone structure and strength QTL 93 17 4.4 34827 D17Rat12 10348 D17Mit4 tibia size trait (VT:0100001) tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727) decreased bone strength osteoporosis 4889918 20699128 17 29605177 65757501 1 - by flanking markers 17 33277173 71214857 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 17 27690959 63994435 1 - by flanking markers 17 27027949 60463643 1 - by flanking markers 4889962 rat Bss94 Bone structure and strength QTL 94 1 3.8 33660 D1Mit9 10442 D1Wox16 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) decreased bone strength osteoporosis 4889918 20699128 1 50204369 84871565 1 - by flanking markers 1 43840481 81947972 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 49547328 83657083 1 - by flanking markers 1 49361465 82174945 1 - by flanking markers 4889966 rat Bss95 Bone structure and strength QTL 95 3 4.4 33782 D3Mit10 36047 D3Rat46 tibia area (VT:1000281) tibia-fibula cross-sectional area (CMO:0001718) decreased bone strength osteoporosis 4889918 20699128 3 1 42991394 4 - by one flank marker only 3 1 33871290 4 - by one flank marker only 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 1 37891710 4 - by one flank marker only 3 1 36847613 4 - by one flank marker only 4889969 rat Bss96 Bone structure and strength QTL 96 4 4.9 33656 D4Mit9 11015 D4Mit24 tibia size trait (VT:0100001) tibia cortical bone volume (CMO:0001725) decreased bone strength osteoporosis 4889918 20699128 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 4889972 rat Bss97 Bone structure and strength QTL 97 4 5.6 33656 D4Mit9 11015 D4Mit24 tibia size trait (VT:0100001) tibia total bone volume (CMO:0001724) decreased bone strength osteoporosis 4889918 20699128 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 4889975 rat Bmd81 Bone mineral density QTL 81 3 4.3 37588 D3Rat189 11260 D3Mit8 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) increased bone mineral density osteoporosis 4889918 20699128 3 44863125 58322647 1 - by flanking markers 3 35797577 47588420 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 3 39773247 51687917 1 - by flanking markers 3 38710365 50302886 1 - by flanking markers 5135224 rat Leukc1 Leukocyte quantity QTL 1 19 36709 D19Rat8 41262 D19Rat57 eosinophil quantity (VT:0002602) blood eosinophil count (CMO:0000033) increased eosinophil cell number Eosinophilia 5135221 16151696 1312024;1582810 Irf8;Zfpm1 recessive 19 59631471 70892142 1 - by flanking markers 19 12235101 57235101 4 - by one flank marker only backcross 1302670 1302728 ACI/NSlc MES/Slc 19 48830712 60220581 1 - by flanking markers 19 44340214 55283277 1 - by flanking markers 5135226 rat Leukc2 Leukocyte quantity QTL 2 2 41358 D2Rat217 35162 D2Rat38 eosinophil quantity (VT:0002602) blood eosinophil count (CMO:0000033) increased eosinophil cell number Eosinophilia 5135221 16151696 additive 2 141390480 175354471 1 - by flanking markers 2 121545310 155102371 1 - by flanking markers 1302670 1302728 ACI/NSlc MES/Slc 2 121750419 155965721 1 - by flanking markers 2 118111229 149559726 1 - by flanking markers 5508828 rat Leukc3 Leukocyte quantity QTL 3 1 37754 D1Rat123 37902 D1Rat169 eosinophil quantity (VT:0002602) blood eosinophil count (CMO:0000033) increased eosinophil cell number Eosinophilia 5135221;5135222 16151696;17090969 1 245518822 251652933 1 - by flanking markers 1 223729174 229876997 1 - by flanking markers 1302670 1302728 ACI/NSlc MES/Slc 1 238220189 244401301 1 - by flanking markers 1 218108584 224054420 1 - by flanking markers 5684888 rat Pia42 Pristane induced arthritis QTL 42 12 11051 D12Mit2 38410 D12Rat53 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) joint inflammation Experimental Arthritis 1302414;1600250 17329308 12 24662983 50380790 1 - by flanking markers 12 20932559 43863270 1 - by flanking markers 1643007 DA.ACI-(D12Wox12-D12Rat53)/Arb 12 22650702 48598906 1 - by flanking markers 12 19610870 42828880 1 - by flanking markers 5684946 rat Bss98 Bone structure and strength QTL 98 15 3.9 0.0026 39940 D15Rat109 33614 D15Mit2 33614 D15Mit2 tibia strength trait (VT:1000284) tibia ultimate force (CMO:0001734) osteopetrosis 5684953 21818327 15 1094146 19829680 1 - by flanking markers 15 1007318 16365960 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 15 1105890 15828368 1 - by flanking markers 15 1058250 14481294 1 - by flanking markers 5684963 rat Bss99 Bone structure and strength QTL 99 6 3.1 34184 D6Mgh11 33897 D3Mit19 tibia area (VT:1000281) tibia area measurement (CMO:0001382) osteopetrosis 5684953 21818327 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5684973 rat Bss100 Bone structure and strength QTL 100 8 4.7 33973 D8Mit2 34310 D8Mgh4 33973 D8Mit2 tibia area (VT:1000281) tibia area measurement (CMO:0001382) osteoporosis 5684953 21818327 8 52685897 88595536 1 - by flanking markers 8 53049279 86628010 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 54065044 89058369 1 - by flanking markers 8 50095249 82460899 1 - by flanking markers 5684990 rat Bmd82 Bone mineral density QTL 82 2 2.8 11156 D2Mit24 34383 D2Mgh5 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 2 84360871 126162742 1 - by flanking markers 2 59700886 106523545 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 2 60325352 106432915 1 - by flanking markers 2 59324377 103795077 1 - by flanking markers 5684992 rat Bmd83 Bone mineral density QTL 82 6 4.8 34184 D6Mgh11 33897 D3Mit19 33897 D3Mit19 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 10017 2302067 GK/KyoSwe F344/DuCrlSwe 5684993 rat Bmd84 Bone mineral density QTL 84 8 4.1 33887 D8Mit3 33973 D8Mit2 33973 D8Mit2 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 8 45061464 52686094 1 - by flanking markers 8 45291674 53049477 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 8 46588437 54065241 1 - by flanking markers 8 42692684 50095447 1 - by flanking markers 5684996 rat Bmd85 Bone mineral density QTL 85 2 4.7 0.024 11156 D2Mit24 34383 D2Mgh5 34383 D2Mgh5 tibia mineral mass (VT:1000283) bone mineral density (CMO:0001226) osteoporosis 5684953 21818327 2 84360871 126162742 1 - by flanking markers 2 59700886 106523545 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 2 60325352 106432915 1 - by flanking markers 2 59324377 103795077 1 - by flanking markers 5684998 rat Bss101 Bone structure and strength QTL 101 1 3.6 35467 D1Rat7 33660 D1Mit9 tibia strength trait (VT:1000284) tibia ultimate force (CMO:0001734) osteoporosis 5684953 21818327 1 17683508 50204515 1 - by flanking markers 1 15999377 43840628 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 16143143 49547474 1 - by flanking markers 1 15431621 49361612 1 - by flanking markers 5684999 rat Bss102 Bone structure and strength QTL 102 1 5.5 7.2E-7 35467 D1Rat7 33660 D1Mit9 34662 D1Mgh2 tibia strength trait (VT:1000284) tibia stiffness (CMO:0001735) osteoporosis 5684953 21818327 1 17683508 50204515 1 - by flanking markers 1 15999377 43840628 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 1 16143143 49547474 1 - by flanking markers 1 15431621 49361612 1 - by flanking markers 5685002 rat Bss103 Bone structure and strength QTL 103 15 2.8 33614 D15Mit2 62030 Myh7 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) osteoporosis 5684953 21818327 15 19829554 37544317 1 - by flanking markers 15 16365832 33094595 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 15 15828242 33657761 1 - by flanking markers 15 14481165 28469888 1 - by flanking markers 5685004 rat Bss104 Bone structure and strength QTL 104 X 3.9 34825 DXRat20 39724 DXRat103 34825 DXRat20 tibia area (VT:1000281) tibia area measurement (CMO:0001382) osteoporosis 5684953 21818327 X 121580137 134700747 1 - by flanking markers X 10563466 134157626 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe X 121442246 134627946 1 - by flanking markers X 113805422 126975220 1 - by flanking markers 5685009 rat Bmd86 Bone mineral density QTL 86 4 3.7 33656 D4Mit9 11015 D4Mit24 tibia mineral mass (VT:1000283) bone mineral density (CMO:0001226) osteoporosis 5684953 21818327 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 5685012 rat Bmd87 Bone mineral density QTL 87 4 5.1 33656 D4Mit9 11015 D4Mit24 33656 D4Mit9 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) osteoporosis 5684953 21818327 4 55067578 144249450 1 - by flanking markers 4 54828069 78039637 1 - by flanking markers 10017 2302067 GK/KyoSwe F344/DuCrlSwe 4 55324857 79575658 1 - by flanking markers 4 56647776 78882945 1 - by flanking markers 5686842 rat Rf59 Renal function QTL 59 3 43714 D3Got102 60365 D3Got121 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) increased urine protein level Albuminuria 5684423 21127141 Albq5_m (maps to syntenic region) 3 153428179 160798463 1 - by flanking markers 3 141890118 149038578 1 - by flanking markers 5686832 ACI.FHH-(D1Mit18-D1Rat90)(D3Got102-D3Got149)(D14Mit11-D14Rat33)(D14Rat65-D14Rat90)/Mcwi 3 147072047 154807958 1 - by flanking markers 3 140069424 146976080 1 - by flanking markers 6478680 rat Anxrr29 Anxiety related response QTL 29 4 9.2E-4 14.0 34493 D4Mgh27 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 4 168999347 213999347 5 - by peak with adj size 4 106808891 151808891 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478684 rat Anxrr30 Anxiety related response QTL 30 4 8.7E-4 14.0 35721 D4Rat76 defecation behavior trait (VT:0010462) defecation rate (CMO:0000998) increased anxiety-related response anxiety disorder 6218999 21516450 4 128465092 173465092 5 - by peak with adj size 4 62386644 107386644 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 63812687 108812687 5 - by peak with adj size 4 62753847 107753847 5 - by peak with adj size 6478686 rat Anxrr31 Anxiety related response QTL 31 4 0.00998 9.0 38912 D4Rat131 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 additive intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478693 rat Anxrr32 Anxiety related response QTL 32 4 9.2E-4 14.0 34338 D4Mgh11 locomotor behavior trait (VT:0001392) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478700 rat Anxrr33 Anxiety related response QTL 33 4 0.00896 10.0 34338 D4Mgh11 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 dominant 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478718 rat Anxrr34 Anxiety related response QTL 34 4 0.00896 10.0 34338 D4Mgh11 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478720 rat Alc23 Alcohol consumption QTL 23 4 0.00509 11.0 40536 D4Rat206 drinking behavior trait (VT:0001422) ethanol drink intake rate to body weight ratio (CMO:0001616) increased alcohol consumption alcohol use disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478724 rat Anxrr35 Anxiety related response QTL 35 4 0.00449 41102 D4Rat151 defecation behavior trait (VT:0010462) defecation measurement (CMO:0000997) increased anxiety-related response anxiety disorder 6218999 21516450 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 6478728 rat Anxrr36 Anxiety related response QTL 36 4 0.01061 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 dominant intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478733 rat Anxrr37 Anxiety related response QTL 37 4 9.5E-4 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478737 rat Anxrr38 Anxiety related response QTL 38 4 0.00159 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478740 rat Anxrr39 Anxiety related response QTL 39 4 0.07528 34493 D4Mgh27 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 4 168999347 213999347 5 - by peak with adj size 4 106808891 151808891 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478743 rat Anxrr40 Anxiety related response QTL 40 4 0.83076 35721 D4Rat76 defecation behavior trait (VT:0010462) defecation rate (CMO:0000998) increased anxiety-related response anxiety disorder 6218999 21516450 4 128465092 173465092 5 - by peak with adj size 4 62386644 107386644 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 63812687 108812687 5 - by peak with adj size 4 62753847 107753847 5 - by peak with adj size 6478745 rat Anxrr41 Anxiety related response QTL 41 4 0.04995 38912 D4Rat131 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478748 rat Anxrr42 Anxiety related response QTL 42 4 0.28008 34338 D4Mgh11 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478754 rat Anxrr43 Anxiety related response QTL 43 4 0.14035 34338 D4Mgh11 locomotor behavior trait (VT:0001392) distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493) increased anxiety-related response anxiety disorder 6218999 21516450 4 208065149 248343840 5 - by peak with adj size 4 148704454 187126005 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 145547014 184226339 5 - by peak with adj size 4 144639524 182687754 5 - by peak with adj size 6478757 rat Anxrr44 Anxiety related response QTL 44 4 0.01087 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478760 rat Anxrr45 Anxiety related response QTL 45 4 0.06717 34106 D4Mgh6 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 dominant 4 175184431 220184431 5 - by peak with adj size 4 113136999 158136999 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 110702761 155702761 5 - by peak with adj size 4 110870972 155870972 5 - by peak with adj size 6478763 rat Anxrr46 Anxiety related response QTL 46 4 0.07428 34106 D4Mgh6 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 175184431 220184431 5 - by peak with adj size 4 113136999 158136999 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 110702761 155702761 5 - by peak with adj size 4 110870972 155870972 5 - by peak with adj size 6478766 rat Anxrr47 Anxiety related response QTL 47 4 0.09637 41102 D4Rat151 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 6478769 rat Anxrr48 Anxiety related response QTL 48 4 0.02514 41102 D4Rat151 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 6478772 rat Anxrr49 Anxiety related response QTL 49 4 0.15488 35721 D4Rat76 defecation behavior trait (VT:0010462) defecation rate (CMO:0000998) increased anxiety-related response anxiety disorder 6218999 21516450 4 128465092 173465092 5 - by peak with adj size 4 62386644 107386644 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 63812687 108812687 5 - by peak with adj size 4 62753847 107753847 5 - by peak with adj size 6478775 rat Anxrr50 Anxiety related response QTL 50 4 0.66021 38912 D4Rat131 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) increased anxiety-related response anxiety disorder 6218999 21516450 inducing agent: subcutaneous injection of estradiol benzoate (10ug/0.1ml) and progesterone (5mg/kg) in a injection volume of 1mg/kg;intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 6478778 rat Anxrr51 Anxiety related response QTL 51 4 0.25384 35088 D4Rat59 locomotor behavior trait (VT:0001392) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) increased anxiety-related response anxiety disorder 6218999 21516450 4 186880256 231880256 5 - by peak with adj size 4 127547983 172547983 5 - by peak with adj size intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 123587009 168587009 5 - by peak with adj size 4 124778595 169778595 5 - by peak with adj size 6478782 rat Anxrr52 Anxiety related response QTL 52 4 0.02091 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6478785 rat Anxrr53 Anxiety related response QTL 53 4 0.01397 40536 D4Rat206 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) increased anxiety-related response anxiety disorder 6218999 21516450 intercross 6218997 6219002 SHR/NCrlAnra LEW/HsdUnibAnra 4 155386197 184226339 5 - by peak with adj size 6480225 rat Gdil1 Gastrointestinal dilation QTL 1 2 42121 D2Arb7 35643 D2Rat21 33739 D2Mit5 enteric ganglion morphology trait (VT:0001045) length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836) aganglionic megacolon Hirschsprung's disease;Total Intestinal Aganglionosis;Waardenburg Syndrome Type 4 6480215;6480217;10402048 22132166;21915282;25790447 2677;1305942 Gdnf;Rai14 2 76649726 95410202 1 - by flanking markers 2 57161998 75806439 1 - by flanking markers intercross 6480218 6480223 AR-Ednrbsl/Hkv F344.AR-Ednrbsl/Hkv 2 58344100 75687607 1 - by flanking markers 2 56660879 74786777 1 - by flanking markers 6480773 rat Gluco64 Glucose level QTL 64 1 5.09 34244 D1Mgh10 43384 D1Got189 38854 D1Rat168 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) impaired glucose tolerance glucose intolerance 2303512;6893578;9587420 22947656;25236446 1311779 Tpcn2 1 223910550 225482294 1 - by flanking markers 1 204280278 205897680 1 - by flanking markers 2314009 NMcwi:HS 1 217054291 218614387 1 - by flanking markers 1 199050459 200611765 1 - by flanking markers 6480777 rat Insul17 Insulin level QTL 17 1 3.86 36239 D1Rat111 33878 D1Mit27 38954 D1Rat181 blood insulin amount (VT:0001560) blood insulin level area under curve (AUC) (CMO:0000351) increased circulating insulin level hyperinsulinism;type 2 diabetes mellitus 2303512;6893578 22947656 1 222009015 223075141 1 - by flanking markers 1 202350579 203303100 1 - by flanking markers 2314009 NMcwi:HS 1 215097781 216213510 1 - by flanking markers 1 197260913 198211706 1 - by flanking markers 6480780 rat Insul18 Insulin level QTL 18 1 4.11 38326 D1Rat129 43384 D1Got189 40534 D1Rat291 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level hyperinsulinism;type 2 diabetes mellitus 2303512;6893578;9587420 22947656;25236446 1311779 Tpcn2 1 218337839 225482294 1 - by flanking markers 1 198853034 205897680 1 - by flanking markers 2314009 NMcwi:HS 1 206950905 218614387 2 - by one flank and peak markers 1 189607473 200611765 2 - by one flank and peak markers 6480783 rat Insul19 Insulin level QTL 19 1 4.33 38326 D1Rat129 43384 D1Got189 34244 D1Mgh10 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) increased circulating insulin level hyperinsulinism;type 2 diabetes mellitus 2303512;6893578;9587420 22947656;25236446 1311779 Tpcn2 1 218337839 225482294 1 - by flanking markers 1 198853034 205897680 1 - by flanking markers 2314009 NMcwi:HS 1 215494321 218614387 2 - by one flank and peak markers 1 197489281 200611765 2 - by one flank and peak markers 6480786 rat Bw97 Body weight QTL 97 1 5.03 34009 D1Mit34 41610 D1Rat300 41392 D1Rat302 body mass (VT:0001259) body weight (CMO:0000012) Weight Gain 2303512;6893578 22947656 1 252776360 255263602 1 - by flanking markers 1 230963695 233551254 1 - by flanking markers 2314009 NMcwi:HS 1 245529606 248013094 1 - by flanking markers 1 225126575 227604520 1 - by flanking markers 6893332 rat Cm74 Cardiac mass QTL 74 6 0.4 0.64 34126 D6Mgh4 33977 D6Mit4 34306 D6Mgh5 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 6 70194178 117391806 1 - by flanking markers 6 59946874 108503674 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 6 60606431 108154445 1 - by flanking markers 6 57730540 104085867 1 - by flanking markers 6893336 rat Cm75 Cardiac mass QTL 75 10 0.1 0.87 34445 D10Mgh6 34128 D10Mgh1 3177 Ngfr heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 10 63366082 103048942 2 - by one flank and peak markers 10 67677924 100865886 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 64648175 102149713 2 - by one flank and peak markers 10 61345276 99703528 2 - by one flank and peak markers 6893338 rat Cm76 Cardiac mass QTL 76 13 0.0 0.99 11375 D13Arb8 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 13 34129640 79129640 5 - by peak with adj size 13 25198204 70198204 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 13 29076934 74076934 5 - by peak with adj size 13 23692969 68692969 5 - by peak with adj size 6893340 rat Cm77 Cardiac mass QTL 77 6 0.26 0.57 33993 D6Mit2 33828 D6Mit9 33977 D6Mit4 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 6 46021394 94275468 1 - by flanking markers 6 34039461 84287190 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 6 36260288 84763275 1 - by flanking markers 6 33309549 81132889 1 - by flanking markers 6893342 rat Cm78 Cardiac mass QTL 78 10 0.1 0.88 34318 D10Mgh10 35563 D10Rat21 34445 D10Mgh6 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 10 35954931 82495564 1 - by flanking markers 10 36254741 83528010 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 10 36185929 82675365 1 - by flanking markers 10 42876766 79813922 2 - by one flank and peak markers 6893344 rat Cm79 Cardiac mass QTL 79 13 1.5 0.04 35925 D13Rat41 11115 D13Mgh7 11375 D13Arb8 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) increased heart weight Left Ventricular Hypertrophy 1554311 16097372 13 54128085 72173144 1 - by flanking markers 13 45161605 64281346 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 13 49058507 67207219 1 - by flanking markers 13 43720770 62022792 1 - by flanking markers 6893347 rat Bw98 Body weight QTL 98 1 0.2 0.53 621323 Phox2a body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 1 150585707 195585707 5 - by peak with adj size 1 136792830 181792830 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 1 144395993 189395993 5 - by peak with adj size 1 133680936 178680936 5 - by peak with adj size 6893350 rat Bw99 Body weight QTL 99 1 0.87 0.16 10792 D10Wox10 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 16898761 61898761 5 - by peak with adj size 10 17185640 62185640 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 17121542 62121542 5 - by peak with adj size 10 15906665 60906665 5 - by peak with adj size 6893352 rat Bw100 Body weight QTL 100 1 0.33 0.6 10792 D10Wox10 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 16898761 61898761 5 - by peak with adj size 10 17185640 62185640 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 17121542 62121542 5 - by peak with adj size 10 15906665 60906665 5 - by peak with adj size 6893355 rat Bw101 Body weight QTL 101 3 0.4 0.38 34347 D3Mgh16 33862 D3Mit9 34347 D3Mgh16 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 3 11361699 39536215 1 - by flanking markers 3 6373335 26674263 1 - by flanking markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 3 6000748 34394365 1 - by flanking markers 3 10778704 30357018 1 - by flanking markers 6893357 rat Bw102 Body weight QTL 102 10 0.5 0.36 3177 Ngfr 34128 D10Mgh1 2493 Ace body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 83198396 104688792 2 - by one flank and peak markers 10 84262804 106479988 2 - by one flank and peak markers 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 10 83389828 104994768 2 - by one flank and peak markers 10 80515287 101325465 2 - by one flank and peak markers 6893359 rat Bw103 Body weight QTL 103 18 1.2 0.12 34290 D18Mgh4 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 18 56512589 87229863 5 - by peak with adj size 18 57085070 87265094 5 - by peak with adj size 1558660 1558661 SHRSP/Tkyo WKY/Tkyo 18 57448678 88201929 5 - by peak with adj size 6893361 rat Bw104 Body weight QTL 104 1 0.59 0.27 621323 Phox2a body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 1 150585707 195585707 5 - by peak with adj size 1 136792830 181792830 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 1 144395993 189395993 5 - by peak with adj size 1 133680936 178680936 5 - by peak with adj size 6893363 rat Bw105 Body weight QTL 105 3 2.6 0.0036 34347 D3Mgh16 33862 D3Mit9 34347 D3Mgh16 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 3 11361699 39536215 1 - by flanking markers 3 6373335 26674263 1 - by flanking markers 1558661 1558662 WKY/Tkyo SHR/Tkyo 3 6000748 34394365 1 - by flanking markers 3 10778704 30357018 1 - by flanking markers 6893366 rat Bw106 Body weight QTL 106 10 0.3 0.47 36624 D10Rat13 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 10 73201303 112200500 5 - by peak with adj size 10 74652410 110718848 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 10 73467158 112626471 5 - by peak with adj size 10 70199100 107211142 5 - by peak with adj size 6893368 rat Bw107 Body weight QTL 107 18 0.3 0.5 34290 D18Mgh4 body mass (VT:0001259) body weight (CMO:0000012) decreased body weight Left Ventricular Hypertrophy 1554311 16097372 18 56512589 87229863 5 - by peak with adj size 18 57085070 87265094 5 - by peak with adj size 1558661 1558662 WKY/Tkyo SHR/Tkyo 18 57448678 88201929 5 - by peak with adj size 6893678 rat Bw108 Body weight QTL 108 4 2.6 0.006 13.9 38728 D4Rat122 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 recessive 4 42237617 87237617 5 - by peak with adj size 4 42249950 87249950 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 4 42415777 87415777 5 - by peak with adj size 4 43457976 88457976 5 - by peak with adj size 6893681 rat Bw109 Body weight QTL 109 12 2.3 0.004 13.3 39814 D12Rat57 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 recessive 12 1 23736622 5 - by peak with adj size 12 1 25938641 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 12 1 23758197 5 - by peak with adj size 12 1 23297788 5 - by peak with adj size 6893683 rat Bw110 Body weight QTL 110 18 2.7 0.002 13.1 34182 D18Mgh3 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 additive 18 44165133 87229863 5 - by peak with adj size 18 46513375 87265094 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 18 45002194 88201929 5 - by peak with adj size 18 43345022 83828827 5 - by peak with adj size 6893685 rat Bw111 Body weight QTL 111 20 2.7 0.004 12.2 37872 D20Rat31 body mass (VT:0001259) body weight (CMO:0000012) increased body weight hypertension 61516 11015598 recessive 20 1 35472592 5 - by peak with adj size 20 1 32910115 5 - by peak with adj size 10041 724574 SS/Jr SHR/NHsd 20 1 33300419 5 - by peak with adj size 20 1 32578807 5 - by peak with adj size 6903292 rat Stl28 Serum triglyceride level QTL 28 5 2.6 0.0073 66655 D5Mco21 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 1299960 14709677 5 34199087 79199087 5 - by peak with adj size 5 30606308 75606308 5 - by peak with adj size 60999 1302795 LEW HTG 5 29641661 74641661 5 - by peak with adj size 5 28515489 73515489 5 - by peak with adj size 6903294 rat Stl30 Serum triglyceride level QTL 30 16 2.6 0.0013 66392 D16Mco7 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Hypertriglyceridemia;Metabolic Syndrome 1299960 14709677 16 28056288 73056288 5 - by peak with adj size 16 28455247 73455247 5 - by peak with adj size 60999 1302795 LEW HTG 16 28340315 73340315 5 - by peak with adj size 16 25152793 70152793 5 - by peak with adj size 6903300 rat Scl33 Serum cholesterol QTL 33 8 2.0 0.0125 37072 D8Rat59 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 8 92612869 132457389 5 - by peak with adj size 8 89742772 129041809 5 - by peak with adj size 60999 1302795 LEW HTG 6903303 rat Scl34 Serum cholesterol QTL 34 1 2.5 0.0033 36592 D1Rat64 37754 D1Rat123 37732 D1Rat208 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 1 204172176 245519018 1 - by flanking markers 1 184857716 223729371 1 - by flanking markers 60999 1302795 LEW HTG 1 197187728 238220385 1 - by flanking markers 1 180359209 218108781 1 - by flanking markers 6903306 rat Scl35 Serum cholesterol QTL 35 5 2.6 0.0073 66655 D5Mco21 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 5 34199087 79199087 5 - by peak with adj size 5 30606308 75606308 5 - by peak with adj size 60999 1302795 LEW HTG 5 29641661 74641661 5 - by peak with adj size 5 28515489 73515489 5 - by peak with adj size 6903308 rat Scl36 Serum cholesterol QTL 36 1 2.0 0.0125 38202 D1Rat229 38792 D1Rat137 35106 D1Rat335 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) increased circulating cholesterol level Hypercholesterolemia;Metabolic Syndrome 1299960 14709677 1 40688397 95326185 2 - by one flank and peak markers 1 53013200 90306478 2 - by one flank and peak markers 60999 1302795 LEW HTG 1 50522714 94225616 1 - by flanking markers 1 53863041 90532583 2 - by one flank and peak markers 6903312 rat Bw112 Body weight QTL 112 2 3.2 0.0013 34234 D2Mgh9 34005 D2Mit8 36213 D2Rat40 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 2 169047413 218191291 1 - by flanking markers 2 148790758 191378142 1 - by flanking markers 60999 1302795 LEW HTG 2 149614623 198704357 1 - by flanking markers 2 143657569 184114274 1 - by flanking markers 6903316 rat Bw113 Body weight QTL 113 5 2.0 0.0103 41424 D5Rat156 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 5 95828682 140828682 5 - by peak with adj size 5 93245548 138245548 5 - by peak with adj size 60999 1302795 LEW HTG 5 91884213 136884213 5 - by peak with adj size 5 87765973 132765973 5 - by peak with adj size 6903319 rat Bw114 Body weight QTL 114 16 2.7 0.0037 35005 D16Rat6 body mass (VT:0001259) body weight (CMO:0000012) increased body weight Metabolic Syndrome;obesity 1299960 14709677 16 136462 45136462 5 - by peak with adj size 16 172013 45172013 5 - by peak with adj size 60999 1302795 LEW HTG 16 244593 45244593 5 - by peak with adj size 16 1 43534949 5 - by peak with adj size 6903345 rat Bp349 Blood pressure QTL 349 18 3.9 33884 D18Mit8 36914 D18Rat18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 47464114 61176840 1 - by flanking markers 18 48759666 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 48249048 61985648 1 - by flanking markers 18 46718935 59796478 1 - by flanking markers 6903347 rat Bp350 Blood pressure QTL 350 18 4.4 33884 D18Mit8 10689 D18Mit5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 32348275 61176840 1 - by flanking markers 18 32458940 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 32670473 61985648 1 - by flanking markers 18 31359530 59796478 1 - by flanking markers 6903349 rat Bp351 Blood pressure QTL 351 18 3.5 33884 D18Mit8 36914 D18Rat18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp352 (maps to same region);Bp54 (sub_region) 18 47464114 61176840 1 - by flanking markers 18 48759666 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 48249048 61985648 1 - by flanking markers 18 46718935 59796478 1 - by flanking markers 6903351 rat Bp352 Blood pressure QTL 352 18 3.3 33884 D18Mit8 36914 D18Rat18 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp351 (maps to same region);Bp54 (sub_region) 18 47464114 61176840 1 - by flanking markers 18 48759666 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 48249048 61985648 1 - by flanking markers 18 46718935 59796478 1 - by flanking markers 6903353 rat Bp353 Blood pressure QTL 353 18 2.8 33884 D18Mit8 34340 D18Mgh7 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial diastolic blood pressure;salt-sensitive hypertension hypertension 69700;7327193 11015589;24023717 2004 A2m Bp54 (sub_region) 18 61176840 87229863 4 - by one flank marker only 18 62228896 87265094 4 - by one flank marker only 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 22604764 61985648 1 - by flanking markers 18 59796478 83828827 4 - by one flank marker only 6903356 rat Bp354 Blood pressure QTL 354 18 4.6 33884 D18Mit8 34092 D18Mgh8 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 61176840 87229863 4 - by one flank marker only 18 15852579 62228896 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 61985648 88201929 4 - by one flank marker only 18 59796478 83828827 4 - by one flank marker only 6903359 rat Bp355 Blood pressure QTL 355 18 3.6 33884 D18Mit8 11461 D18Mit1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure;salt-sensitive hypertension hypertension 69700 11015589 Bp54 (sub_region) 18 15314271 61176840 1 - by flanking markers 18 62228896 80277631 1 - by flanking markers 61498 61499 BN/NHsdMcwi SS/JrHsdMcwi 18 15539671 61985648 1 - by flanking markers 18 11944544 59796478 1 - by flanking markers 6903937 rat Bp356 Blood pressure QTL 356 9 0.001 2302905 D9Mco72 6903888 D9Mco105 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial diastolic blood pressure;decreased systemic arterial systolic blood pressure Hypotension 6903249 21814219 Bp333 (sub_region) 9 52352690 97352690 4 - by one flank marker only 9 44842118 89842118 4 - by one flank marker only 6903925 SS.SHR-(D9Mco72-D9Mco105)/Mco 9 52686874 57216771 1 - by flanking markers 9 47902208 52283252 1 - by flanking markers 6903941 rat Pur31 Proteinuria QTL 31 9 0.036 36924 D9Rat7 37724 D9Rat84 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) decreased urine protein level proteinuria 6903249 21814219 Bp334 (sub_region) 9 83453664 91313982 1 - by flanking markers 9 77172934 83316504 1 - by flanking markers 6903936 SS.SHR-(D9Rat7-D9Rat84)/Mco 9 46579769 91579769 4 - by one flank marker only 9 40194188 85194188 4 - by one flank marker only 6907110 rat Mcs28 Mammary carcinoma susceptibility QTL 28 5 6904173 D5Uwm82 6904193 D5Uwm92 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) decreased mammary gland tumor incidence Experimental Mammary Neoplasms 5684388 21205740 Mcs14 (sub_region) 5 84254534 84549684 1 - by flanking markers 6907090 WF.WKY-(D5Uwm78-D5Uwm93)/Uwm 5 80154593 80451339 1 - by flanking markers 5 77743239 78039084 1 - by flanking markers 6907115 rat Mcs29 Mammary carcinoma susceptibility QTL 29 5 6904179 D5Uwm85 6904185 D5Uwm88 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary gland tumor incidence Experimental Mammary Neoplasms 5684388 21205740 Mcs14 (sub_region) 5 84329164 84499632 1 - by flanking markers 6907100 WF.WKY-(D5Uwm82-D5Uwm91)/Uwm 5 80229223 80401274 1 - by flanking markers 5 77816155 77988860 1 - by flanking markers 6907363 rat Bp357 Blood pressure QTL 357 2 4.1 0.002 10386 D2Wox15 11108 D2Wox19 10386 D2Wox15 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) increased systemic arterial blood pressure hypertension 61058 9329963 2 162863444 207863444 4 - by one flank marker only 2 136212270 181212270 4 - by one flank marker only 60990 61015 LH/MavRrrc LN/MavRrrc 2 143447078 188447078 4 - by one flank marker only 2 129540907 174540907 4 - by one flank marker only 6909122 rat Insul22 Insulin level QTL 22 4 4.63 36127 D4Rat9 34943 D4Rat30 35625 D4Rat14 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) decreased circulating insulin level 1626640 17213368 dominant 4 23916923 140915120 1 - by flanking markers 4 23537363 74625985 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 4 23991721 76238799 1 - by flanking markers 4 26907285 75585128 1 - by flanking markers 6909128 rat Pancm4 Pancreatic morphology QTL 4 4 11.35 36127 D4Rat9 34943 D4Rat30 35675 D4Rat28 pancreas mass (VT:0010144) pancreas wet weight (CMO:0000626) decreased pancreas weight 1626640 17213368 4 23916923 140915120 1 - by flanking markers 4 23537363 74625985 1 - by flanking markers 1357181 1357191 CDR/Ygl CDS/Ygl 4 23991721 76238799 1 - by flanking markers 4 26907285 75585128 1 - by flanking markers 7175096 rat Tcs1 T cell selection QTL 1 20 1303324 Brd2 1303306 Cuta T cell selection trait (VT:0004917) expression 7175101;8662970 22391806 20 7323184 7592657 1 - by flanking markers 20 4864606 5176689 1 - by flanking markers 634373 2307301 DA/ZtmRhd DA.LEW.RT1f-(D20Wox15-D20Wox13)/Rhd 20 3910555 5533640 1 - by flanking markers 12743640 DA.E3-(RT1-DMa-Ggnbp1) 20 4727078 5024580 1 - by flanking markers 7175099 rat Tcs2 T cell selection QTL 2 20 735096 RT1-DMb 620731 Btnl2 T cell selection trait (VT:0004917) expression 7175101;8662970 22391806 20 6236503 7288114 1 - by flanking markers 20 4625383 4829535 1 - by flanking markers 634373 2307301 DA/ZtmRhd DA.LEW.RT1f-(D20Wox15-D20Wox13)/Rhd 20 3945383 4156365 1 - by flanking markers 20 4504002 4693102 1 - by flanking markers 7204484 rat Bp358 Blood pressure QTL 358 12 0.001 5683878 D12Hmgc3 5683884 D12Hmgc6 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) increased mean systemic arterial blood pressure;increased urine protein level Albuminuria;hypertension;proteinuria 7204442;8693701;9685385 22868394;25001272;25320330 12 17102817 24300160 1 - by flanking markers 5683890 SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi 12 15085585 22283507 1 - by flanking markers 12 13008296 19212979 1 - by flanking markers 7205510 rat Activ5 Activity QTL 5 16 3.78 2.8E-4 41248 D16Rat58 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) acute stress disorder 2306974 19089625 16 46234202 90051983 5 - by peak with adj size 16 46718586 90238779 5 - by peak with adj size F2 of reciprocal crosses 61008 2292168 WAG ISIAH 16 46558188 90668790 5 - by peak with adj size 16 42396345 84729064 5 - by peak with adj size 7207480 rat Bss105 Bone structure and strength QTL 105 4 8.1 35070 D4Rat57 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 1549683 16059631 4 174127594 219127594 5 - by peak with adj size 4 112039347 157039347 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 4 109636356 154636356 5 - by peak with adj size 4 109827074 154827074 5 - by peak with adj size 7207481 rat Bss106 Bone structure and strength QTL 106 5 7.9 35060 D5Rat29 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207482 rat Bss107 Bone structure and strength QTL 107 2 7.0 34864 D2Rat67 femur strength trait (VT:0010010) femur ultimate force (CMO:0001675) 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 7207484 rat Bss108 Bone structure and strength QTL 108 2 5.3 34864 D2Rat67 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 7207486 rat Bss109 Bone structure and strength QTL 109 5 35060 D5Rat29 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207488 rat Bss110 Bone structure and strength QTL 1 5 8.4 35060 D5Rat29 femur strength trait (VT:0010010) femur stiffness (CMO:0001674) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207490 rat Bss111 Bone structure and strength QTL 111 2 6.4 34864 D2Rat67 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 1549683 16059631 2 247240006 285068071 5 - by peak with adj size 2 221002002 258207540 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 2 228712271 266435125 5 - by peak with adj size 2 211744537 249053267 5 - by peak with adj size 7207491 rat Bss112 Bone structure and strength QTL 112 5 7.0 35060 D5Rat29 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 1549683 16059631 5 116062529 161062529 5 - by peak with adj size 5 113689301 158689301 5 - by peak with adj size 61109 1298093 F344/NHsd LEW/NHsd 5 112279412 157279412 5 - by peak with adj size 5 106906205 151906205 5 - by peak with adj size 7207805 rat Bmd88 Bone mineral density QTL 88 9 4.0 40738 D9Rat130 40916 D9Rat123 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 2293456 18282130 9 26333329 63071752 1 - by flanking markers 9 20102034 55470344 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 9 27486036 63264281 1 - by flanking markers 9 23754024 58157242 1 - by flanking markers 7207808 rat Bmd89 Bone mineral density QTL 89 2 4.1 40462 D2Rat280 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) 2293456 18282130 2 111366095 156366095 5 - by peak with adj size 10011 734475 COP/OlaHsd DA/OlaHsd 2 91664872 136664872 5 - by peak with adj size 2 88862519 133862519 5 - by peak with adj size 7207811 rat Bmd90 Bone mineral density QTL 90 10 5.2 40302 D10Rat162 37900 D10Rat124 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 2293456 18282130 10 51047525 84389655 1 - by flanking markers 10 51099067 85484602 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 10 51289203 84596393 1 - by flanking markers 10 49444551 81709989 1 - by flanking markers 7207814 rat Bmd91 Bone mineral density QTL 91 9 3.5 40080 D9Rat144 40738 D9Rat130 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 2293456 18282130 9 26333448 88080598 1 - by flanking markers 9 20102447 81885455 1 - by flanking markers 10011 734475 COP/OlaHsd DA/OlaHsd 9 27486155 88333183 1 - by flanking markers 9 23754144 83851531 1 - by flanking markers 7207885 rat Glom27 Glomerulus QTL 27 13 3.9 34945 D13Rat51 36699 D13Rat1 39262 D13Rat86 kidney glomerulus integrity trait (VT:0010546) kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139) glomerulonephritis anti-basement membrane glomerulonephritis;crescentic glomerulonephritis 7207870 22445570 2599;71069;631331 Fcer1g;Fcgr2a;Fcgr2b 13 29680295 113387011 1 - by flanking markers 13 10556042 106075835 1 - by flanking markers 737922 1358112 LEW/SsNHsd WKY/NCrl 13 24502279 108770533 1 - by flanking markers 13 20605871 101339738 1 - by flanking markers 7243862 rat Mcs30 Mammary carcinoma susceptibility QTL 30 12 8.62 39814 D12Rat57 41960 D12Arb2 39744 D12Rat59 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7327193;7243871 24023717 1307034 Fry 12 1236564 12361764 1 - by flanking markers 12 1581198 3438700 2 - by one flank and peak markers 10011 61109 COP/OlaHsd F344/NHsd 12 1258139 10257059 1 - by flanking markers 12 797729 8525593 1 - by flanking markers 7247442 rat Uae39 Urinary albumin excretion QTL 39 19 66451 D19Uia1 39128 D19Rat34 40950 D19Rat74 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 1578520 16534143 19 2413720 69195220 2 - by one flank and peak markers 19 2264957 50012399 2 - by one flank and peak markers 10041 724574 SS/Jr SHR/NHsd 19 2432963 47217667 2 - by one flank and peak markers 19 2187927 46708701 2 - by one flank and peak markers 7365049 rat Bp359 Blood pressure QTL 359 5 7365009 rs105835643 7365016 rs106808193 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 7364997;10755344 22860086;22912817 68945;737548 Cyp4a1;EDN2 Bp292 (sub_region) 5 137146119 143913027 1 - by flanking markers 5 134909988 141744732 1 - by flanking markers 7365043 SS.SR-(rs65785750-rs106808193)/Opaz 5 133351969 140120264 1 - by flanking markers 5 128071929 134724733 1 - by flanking markers 7387227 rat Uae40 Urinary albumin excretion QTL 40 4 2.9 0.0052 7387228 rs8168428 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 4 15986671 60986671 5 - by peak with adj size 4 15103232 60103232 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 4 16149941 61149941 5 - by peak with adj size 4 17946999 62946999 5 - by peak with adj size 7387235 rat Uae41 Urinary albumin excretion QTL 41 10 5.26 0.1874 7387245 rs8165230 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 10 1 28393470 5 - by peak with adj size 10 1 29537210 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 10 1 29592136 5 - by peak with adj size 10 1 29497586 5 - by peak with adj size 7387267 rat Uae42 Urinary albumin excretion QTL 42 14 0.61 7387248 rs105610447 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 14 23845575 68845575 5 - by peak with adj size 14 24876732 69876732 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 18 21639491 66639491 5 - by peak with adj size 14 22167967 67167967 5 - by peak with adj size 7387280 rat Uae43 Urinary albumin excretion QTL 43 13 5.69 0.4174 7387249 rs8156450 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 13 77035361 118718031 5 - by peak with adj size 13 70309799 111154910 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 13 72583716 114033958 5 - by peak with adj size 13 66451204 106807694 5 - by peak with adj size 7387283 rat Uae44 Urinary albumin excretion QTL 44 20 0.1712 7387255 rs8153618 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117 20159938 additive 20 1 29437823 5 - by peak with adj size 20 1 26162594 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 20 1 27357423 5 - by peak with adj size 20 1 26123605 5 - by peak with adj size 7387289 rat Uae45 Urinary albumin excretion QTL 45 1 2.86 0.0021 7387284 rs8158000 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7387321;7365117 22968639;20159938 additive 1 251578826 290094216 5 - by peak with adj size 1 229695468 267910886 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 1 244148899 282763074 5 - by peak with adj size 1 223262787 260522016 5 - by peak with adj size 7387292 rat Kidm42 Kidney mass QTL 42 12 3.03 4.0E-4 7387286 rs8164304 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) increased kidney weight Albuminuria 7365117 20159938 additive 12 1 40333461 5 - by peak with adj size 12 1 36719145 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 12 1 38334225 5 - by peak with adj size 12 1 36247923 5 - by peak with adj size 7387306 rat Bw124 Body weight QTL 124 3 3.2 3.0E-4 7387301 rs8152181 body mass (VT:0001259) body weight (CMO:0000012) increased body weight obesity 7365117 20159938 additive 3 95458497 140458497 5 - by peak with adj size 3 83621705 128621705 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 3 88910015 133910015 5 - by peak with adj size 3 84091273 129091273 5 - by peak with adj size 7387312 rat Bw125 Body weight QTL 125 10 3.0 0.0047 7387304 rs8163932 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight (CMO:0000356) increased retroperitoneal fat pad weight obesity 7365117 20159938 additive 10 67668577 112200500 5 - by peak with adj size 10 69039078 110718848 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 10 67880046 112626471 5 - by peak with adj size 10 64890616 107211142 5 - by peak with adj size 7387318 rat Stl32 Serum triglyceride level QTL 32 2 3.2 3.0E-4 7387293 rs8160961 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) increased circulating triglyceride level Albuminuria 7365117 20159938 additive 2 41645759 86645759 5 - by peak with adj size 2 22134570 67134570 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 2 22612952 67612952 5 - by peak with adj size 2 22384627 67384627 5 - by peak with adj size 7394701 rat Uae46 Urinary albumin excretion QTL 46 1 3.6 0.0056 37902 D1Rat169 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) albuminuria Albuminuria 7365117;7387321 20159938;22968639 additive 1 229152870 274152870 5 - by peak with adj size 1 207376933 252376933 5 - by peak with adj size backcross 629462 737972 ZUC-LeprfaSte-/- BN/Crl 1 221901238 266901238 5 - by peak with adj size 1 201554356 246554356 5 - by peak with adj size 7394708 rat Emca11 Estrogen-induced mammary cancer QTL 11 5 41576 D5Rat151 36687 D5Rat25 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 7364727 23151807 2323;2324 Cdkn2a;Cdkn2b 5 107580080 120980183 1 - by flanking markers 5 104231741 118805723 1 - by flanking markers 5135475 ACI.BN-(D5Rat60-D5Rat115)/Shul 5 103580245 117037276 1 - by flanking markers 5 99753548 113061097 1 - by flanking markers 7394710 rat Emca12 Estrogen-induced mammary cancer QTL 12 5 60485 D5Got42 37362 D5Rat86 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 7364727 23151807 2325 Cdkn2c 5 132878119 142889552 1 - by flanking markers 5 130756424 140741152 1 - by flanking markers 5135472 ACI.BN-(D5Uwm70-D5Rat32)/Shul 5 129038716 139099229 1 - by flanking markers 5 124160767 133749643 1 - by flanking markers 7394712 rat Emca13 Estrogen-induced mammary cancer QTL 13 5 41076 D5Rat121 41576 D5Rat151 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) increased mammary adenocarcinoma incidence Experimental Mammary Neoplasms 7364727 23151807 5 14314206 107580201 1 - by flanking markers 5 9396684 104231900 1 - by flanking markers 5509087 ACI.BN-(D5Rat113-D5Rat159)/Shul 5 9514842 103580403 1 - by flanking markers 5 9823266 99753708 1 - by flanking markers 7394826 rat Bw126 Body weight QTL 126 4 0.002 10144 D4Mgh16 1310809 Lancl2 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight 7394775 23312492 3197;70547;1310809;1589007 Npy;Crhr2;Lancl2;Jazf1 Alc22 (sub_region) 4 61427427 153387979 1 - by flanking markers 4 61646674 87236803 1 - by flanking markers 7394818 P.NP-(D4Mgh16-D4Rat173)/Iusm 4 61708103 88565113 1 - by flanking markers 4 62933269 87483707 1 - by flanking markers 7394837 rat Memor18 Memory QTL 18 17 7394842 rs65978719 35258 D17Rat36 exploratory behavior trait (VT:0010471) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) abnormal spatial learning Memory Disorders;learning disability 7394833 23469157 1594794 Smokxl1 Memor5 (sub_region) 17 23744952 68744952 4 - by one flank marker only 17 29663991 74663991 4 - by one flank marker only 17 61355300 67004384 1 - by flanking markers 17 56396477 63640182 1 - by flanking markers 7411542 rat Bw127 Body weight QTL 127 6 5.5 0.001 14.3 37298 D6Rat105 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 6 7284088 52284088 5 - by peak with adj size 6 1 41116093 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 42388212 5 - by peak with adj size 6 1 41223769 5 - by peak with adj size 7411545 rat Bw128 Body weight QTL 128 12 5.2 0.001 22.0 11051 D12Mit2 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 620500;620514 Acacb;Acads Niddm27 (maps to same region) 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411547 rat Bw129 Body weight QTL 129 6 0.001 34729 D12Mgh5 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411549 rat Bw130 Body weight QTL 130 19 5.0 0.001 25.3 11389 D19Mgh2 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 2068;2835;3094 Agrp;Hsd11b2;Nr3c2 Niddm38 (maps to same region) 19 30001115 72914587 5 - by peak with adj size 19 17363203 59218465 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 19177495 62275575 5 - by peak with adj size 19 15455860 57337602 5 - by peak with adj size 7411551 rat Bw131 Body weight QTL 131 2 29.6 0.001 23.7 37816 D2Rat145 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 69309 Fabp4 2 89894169 134894169 5 - by peak with adj size 2 69731592 114731592 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 70132175 115132175 5 - by peak with adj size 2 67942638 112942638 5 - by peak with adj size 7411555 rat Bw132 Body weight QTL 132 2 0.001 35340 D2Rat70 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 620500 Acacb 2 259350386 285068071 5 - by peak with adj size 2 232433276 258207540 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 2 240679103 266435125 5 - by peak with adj size 2 223389739 249053267 5 - by peak with adj size 7411558 rat Bw133 Body weight QTL 133 4 13.84 0.001 5.4 37592 D4Rat141 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 4 187731662 232731662 5 - by peak with adj size 4 128658759 173658759 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 124442168 169442168 5 - by peak with adj size 4 125590636 170590636 5 - by peak with adj size 7411561 rat Bw134 Body weight QTL 134 5 24.0 0.001 22.8 34057 D5Mit17 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 5 55954492 100954492 5 - by peak with adj size 5 52659478 97659478 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 51804426 96804426 5 - by peak with adj size 5 49463600 94463600 5 - by peak with adj size 7411564 rat Bw135 Body weight QTL 135 5 0.001 39066 D5Rat71 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 5 95532085 140532085 5 - by peak with adj size 5 92932036 137932036 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 91585539 136585539 5 - by peak with adj size 5 87468046 132468046 5 - by peak with adj size 7411566 rat Bw136 Body weight QTL 136 7 10.4 0.001 7.1 37382 D7Rat113 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 7 1 34998235 5 - by peak with adj size 7 1 33473674 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 1 34828535 5 - by peak with adj size 7 1 31962314 5 - by peak with adj size 7411569 rat Bw137 Body weight QTL 137 7 0.001 37258 D7Rat107 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 7 28217659 73217659 5 - by peak with adj size 7 25365521 70365521 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 28204653 73204653 5 - by peak with adj size 7 21921195 66921195 5 - by peak with adj size 7411571 rat Bw138 Body weight QTL 138 9 14.3 0.001 5.8 35575 D9Rat22 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 9 37329677 82329677 5 - by peak with adj size 9 29793022 74793022 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 37642351 82642351 5 - by peak with adj size 9 32535505 77535505 5 - by peak with adj size 7411573 rat Bw139 Body weight QTL 139 14 4.7 0.001 1.8 39426 D14Rat77 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 14 1 41243137 5 - by peak with adj size 14 1 41281546 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 14 1 41333960 5 - by peak with adj size 7411575 rat Bw140 Body weight QTL 140 17 30.2 0.001 26.3 35707 D17Rat43 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 17 54069664 92503511 5 - by peak with adj size 17 59837302 97296363 5 - by peak with adj size 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 52410957 90843779 5 - by peak with adj size 17 48560935 86533673 5 - by peak with adj size 7411577 rat Bw141 Body weight QTL 141 17 0.001 35719 D17Rat51 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 17 69178062 92503511 5 - by peak with adj size 17 74087839 97296363 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 67512657 90843779 5 - by peak with adj size 17 62619516 86533673 5 - by peak with adj size 7411579 rat Bw142 Body weight QTL 142 19 12.7 0.001 6.6 36436 D19Rat4 body mass (VT:0001259) body weight gain (CMO:0000420) increased body weight Body Weight 7401255 23596094 19 46986857 72914587 5 - by peak with adj size 19 33684571 59218465 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411582 rat Foco3 Food consumption QTL 3 5 7.5 0.001 13.8 39066 D5Rat71 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 5 95532085 140532085 5 - by peak with adj size 5 92932036 137932036 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 91585539 136585539 5 - by peak with adj size 5 87468046 132468046 5 - by peak with adj size 7411584 rat Foco4 Food consumption QTL 4 6 4.3 0.001 6.0 35683 D6Rat39 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 6 8905438 53905438 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 44015370 5 - by peak with adj size 6 1 42838846 5 - by peak with adj size 7411586 rat Foco5 Food consumption QTL 5 12 5.4 0.001 19.0 11051 D12Mit2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 Alc10 (maps to same region) 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411588 rat Foco6 Food consumption QTL 6 12 0.001 34729 D12Mgh5 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 620500;620514 Acacb;Acads Alc10 (maps to same region);Alc6 (maps to same region) 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411590 rat Foco7 Food consumption QTL 7 19 6.8 0.001 19.6 39128 D19Rat34 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 19 1 24913847 5 - by peak with adj size 19 1 24765162 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 19 1 24933090 5 - by peak with adj size 19 1 24688055 5 - by peak with adj size 7411592 rat Foco8 Food consumption QTL 8 9 7.4 0.001 45.6 41556 D9Rat132 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 9 1 39272707 5 - by peak with adj size 9 1 33599535 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 1 40383872 5 - by peak with adj size 9 1 37999212 5 - by peak with adj size 7411595 rat Foco9 Food consumption QTL 9 12 4.0 0.001 20.2 11051 D12Mit2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411597 rat Foco10 Food consumption QTL 10 12 0.001 34729 D12Mgh5 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 620500;620514 Acacb;Acads 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411599 rat Foco11 Food consumption QTL 11 1 18.5 0.001 6.5 33646 D1Mit4 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411601 rat Foco12 Food consumption QTL 12 5 19.7 0.001 8.5 39066 D5Rat71 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 5 95532085 140532085 5 - by peak with adj size 5 92932036 137932036 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 91585539 136585539 5 - by peak with adj size 5 87468046 132468046 5 - by peak with adj size 7411603 rat Foco13 Food consumption QTL 13 6 5.5 0.001 1.6 37298 D6Rat105 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 6 7284088 52284088 5 - by peak with adj size 6 1 41116093 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 1 42388212 5 - by peak with adj size 6 1 41223769 5 - by peak with adj size 7411605 rat Foco14 Food consumption QTL 14 7 24.1 0.001 22.4 36099 D7Rat25 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 7 41096572 86096572 5 - by peak with adj size 7 38076588 83076588 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 40872682 85872682 5 - by peak with adj size 7 34293282 79293282 5 - by peak with adj size 7411607 rat Foco15 Food consumption QTL 15 7 0.001 40900 D7Rat134 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 7 85533213 130533213 5 - by peak with adj size 7 81536235 126536235 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 85595369 130595369 5 - by peak with adj size 7 75918751 120918751 5 - by peak with adj size 7411609 rat Foco16 Food consumption QTL 16 9 25.6 0.001 9.5 34286 D9Mgh6 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 9 11237901 56237901 5 - by peak with adj size 9 5373734 50373734 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 12425463 57425463 5 - by peak with adj size 9 8952560 53952560 5 - by peak with adj size 7411611 rat Foco17 Food consumption QTL 17 10 18.7 0.001 9.1 36249 D10Rat45 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 727858 Npw Alc12 (maps to same region);Alc5 (maps to same region);Alc9 (maps to same region);Kcal2_m (maps to same region) 10 1 42546405 5 - by peak with adj size 10 1 42733142 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 1 42669970 5 - by peak with adj size 10 1 42315980 5 - by peak with adj size 7411614 rat Foco18 Food consumption QTL 18 10 0.001 38936 D10Rat98 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 10 46483741 91483741 5 - by peak with adj size 10 47691367 92691367 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 10 46848346 91848346 5 - by peak with adj size 10 44441699 89441699 5 - by peak with adj size 7411641 rat Foco19 Food consumption QTL 19 12 27.7 0.001 13.2 34729 D12Mgh5 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 Alc10 (maps to same region);Alc6 (maps to same region) 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 7411643 rat Foco20 Food consumption QTL 20 12 0.001 38410 D12Rat53 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 620500 Acacb 12 27880729 54450796 5 - by peak with adj size 12 21363209 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 26098845 52716770 5 - by peak with adj size 12 20328819 46669029 5 - by peak with adj size 7411646 rat Foco21 Food consumption QTL 21 15 23.7 0.001 7.5 36602 D15Rat29 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 15 85887326 109758846 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411648 rat Foco22 Food consumption QTL 22 16 15.0 0.001 5.5 36988 D16Rat15 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 16 57386398 90051983 5 - by peak with adj size 16 57547058 90238779 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 57816357 90668790 5 - by peak with adj size 16 52726464 84729064 5 - by peak with adj size 7411650 rat Foco23 Food consumption QTL 23 20 20.7 0.001 6.7 34280 D20Mgh4 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 Kcal2_m (maps to syntenic region) 20 1 30410692 5 - by peak with adj size 20 1 29380417 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 28375393 5 - by peak with adj size 20 1 29191651 5 - by peak with adj size 7411652 rat Foco24 Food consumption QTL 24 20 0.001 35327 D20Rat10 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 20 15583813 57791882 5 - by peak with adj size 20 11142700 55268282 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 13834309 56205956 5 - by peak with adj size 20 11757515 54435887 5 - by peak with adj size 7411654 rat Foco25 Food consumption QTL 25 7 9.3 0.001 11.5 40900 D7Rat134 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 7 85533213 130533213 5 - by peak with adj size 7 81536235 126536235 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7 85595369 130595369 5 - by peak with adj size 7 75918751 120918751 5 - by peak with adj size 7411656 rat Foco26 Food consumption QTL 26 9 9.8 0.001 7.4 35575 D9Rat22 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 9 37329677 82329677 5 - by peak with adj size 9 29793022 74793022 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 9 37642351 82642351 5 - by peak with adj size 9 32535505 77535505 5 - by peak with adj size 7411658 rat Foco27 Food consumption QTL 27 11 16.2 0.001 15.1 37942 D11Rat46 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 11 63034217 93518069 5 - by peak with adj size 11 58591436 87759784 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 11 59943023 90463843 5 - by peak with adj size 11 56351424 86241447 5 - by peak with adj size 7411660 rat Foco28 Food consumption QTL 28 12 10.9 0.001 11.9 11051 D12Mit2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 12 2163091 47163091 5 - by peak with adj size 12 1 43432667 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 150810 45150810 5 - by peak with adj size 12 1 42110980 5 - by peak with adj size 7411662 rat Foco29 Food consumption QTL 29 13 20.8 0.001 17.4 34140 D13Mgh2 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 13 19195754 64195754 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 13 14096330 59096330 5 - by peak with adj size 13 9313465 54313465 5 - by peak with adj size 7411664 rat Foco30 Food consumption QTL 30 16 11.0 0.001 5.8 40906 D16Rat73 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 16 1224948 46224948 5 - by peak with adj size 16 1223376 46223376 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 16 1340741 46340741 5 - by peak with adj size 16 1 44588133 5 - by peak with adj size 7411666 rat Foco31 Food consumption QTL 31 17 11.4 0.001 9.9 39752 D17Rat118 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 17 16409641 61409641 5 - by peak with adj size 17 19150649 64150649 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 7411668 rat Foco32 Food consumption QTL 32 20 8.0 0.001 7.0 40318 D20Rat60 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) increased body weight;increased food intake Body Weight 7401255 23596094 20 1 39737376 5 - by peak with adj size 20 1 37105774 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 20 1 37550487 5 - by peak with adj size 20 1 36600972 5 - by peak with adj size 7411712 rat Strs4 Sensitivity to stroke QTL 4 1 8.7 10337 D1Mgh5 37384 D1Rat161 37176 D1Rat178 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia Stroke 7411685 23690346 Strs1 (maps to same region) 1 80946174 97911264 1 - by flanking markers 1 78134304 91611235 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 1 79689548 124689548 4 - by one flank marker only 1 78430536 123430536 4 - by one flank marker only 7411719 rat Strs5 Sensitivity to stroke QTL 5 18 9.4 39308 D18Rat73 34182 D18Mgh3 37628 D18Rat41 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia Stroke 7411685 23690346 18 50804228 66665205 1 - by flanking markers 18 52290789 69013448 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 18 51609032 67502266 1 - by flanking markers 18 49999958 65845095 1 - by flanking markers 7411722 rat Strs6 Sensitivity to stroke QTL 6 5 3.9 36103 D5Rat36 34706 D5Mgh18 3193 Nppa cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia Stroke 7411685 23690346 5 144173708 147610023 1 - by flanking markers 5 141999859 145186817 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 5 140387005 143846157 1 - by flanking markers 5 134972980 138113556 1 - by flanking markers 7411725 rat Strs7 Sensitivity to stroke QTL 7 15 3.8 620732 Ephx2 34805 D15Rat32 37954 D15Rat61 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) brain ischemia;increased systemic arterial blood pressure Stroke;hypertension 7411685 23690346 15 48799823 59747340 1 - by flanking markers 15 45497660 54808556 1 - by flanking markers 631577 631599 SHR/Izm SHRSP/Izm 15 42757241 56027084 1 - by flanking markers 15 40289901 49308583 1 - by flanking markers 7421626 rat Bp360 Blood pressure QTL 360 1 0.001 35891 D1Rat19 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 1 5173266 50173266 4 - by one flank marker only 1 1 43872827 4 - by one flank marker only 7421599 SS.LEW-(D1Chm64-D1Rat19)/Ayd 1 4578693 49578693 4 - by one flank marker only 1 4393289 49393289 4 - by one flank marker only 7421628 rat Bp361 Blood pressure QTL 361 1 0.001 62475 D1Uia4 39428 D1Rat320 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 Bp310 (interacts with) 1 63580258 126980655 1 - by flanking markers 1 64343599 119536913 1 - by flanking markers 7421606 SS.LEW-(D1Uia4-D1Rat320)/Ayd 1 64588516 125875986 1 - by flanking markers 1 66023617 118608521 1 - by flanking markers 7421630 rat Bp362 Blood pressure QTL 362 1 0.001 39428 D1Rat320 34517 D1Mgh32 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 1 126980427 269885827 1 - by flanking markers 1 119536684 247882384 1 - by flanking markers 7421603 SS.LEW-(D1Rat320-D1Mgh32)/Ayd 1 125875758 262433692 1 - by flanking markers 1 118608292 241799120 1 - by flanking markers 7488904 rat Bp363 Blood pressure QTL 363 2 0.001 38068 D2Rat155 3195 Npr1 3195 Npr1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 3195 Npr1 Bp257 (sub_region);Bp364 (interacts with) 2 206293779 209287892 1 - by flanking markers 2 179581946 182740242 1 - by flanking markers 7421645 SS.MNS-(D2Rat155-D2Chm419)/Ayd 2 186889035 189857032 1 - by flanking markers 2 172982062 175950118 1 - by flanking markers 7488925 rat Bp364 Blood pressure QTL 364 2 0.001 61810 Ctsk arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 61810 Ctsk Bp257 (sub_region);Bp363 (interacts with) 2 193659473 238659473 5 - by peak with adj size 2 167900261 212900261 5 - by peak with adj size 7421643 SS.MNS-(D2Chm254-D2Chm161)/Ayd 2 174160958 219160958 5 - by peak with adj size 2 160564068 205564068 5 - by peak with adj size 7488927 rat Bp365 Blood pressure QTL 365 2 0.008 620905 Prkab2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500;9685142 19461651;23814039;25380161 620905 Prkab2 Bp257 (sub_region);Bp279 (interacts with);Bp310 (interacts with) 2 196817598 241817598 5 - by peak with adj size 2 170004527 215004527 5 - by peak with adj size 7421647 SS.MNS-(D2Chm161-D2Chm410)/Ayd 2 177339806 222339806 5 - by peak with adj size 2 162765032 207765032 5 - by peak with adj size 7488929 rat Bp366 Blood pressure QTL 366 2 0.001 34759 D2Rat52 2167 Atp1a1 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 2167 Atp1a1 2 219408246 227502148 2 - by one flank and peak markers 2 192478177 200866813 2 - by one flank and peak markers 7421654 SS.MNS-(D2Chm366-D2Rat52)/Ayd 2 199954569 208081195 2 - by one flank and peak markers 2 184974550 193094998 2 - by one flank and peak markers 7488931 rat Bp367 Blood pressure QTL 367 2 0.001 1358019 D2Chm122 1358052 D2Chm90 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 621826 Pfn2 Bp256 (sub_region) 2 164047103 167706680 1 - by flanking markers 2 144445607 147424436 1 - by flanking markers 1358156 SS.MNS-(D2Rat183-D2Chm113)/Ayd 2 144631170 148295508 1 - by flanking markers 2 139401804 142323610 1 - by flanking markers 7488933 rat Bp368 Blood pressure QTL 368 2 0.004 1358052 D2Chm90 3098 Mme arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased systemic arterial blood pressure Hypotension 7421631;7421500 19461651;23814039 3098 Mme Bp258 (sub_region) 2 167706439 173278946 1 - by flanking markers 2 147424195 153114515 1 - by flanking markers 7421636 SS.MNS-(D2Chm90-D2Rat38)/Ayd 2 148295267 153880910 1 - by flanking markers 2 142323368 147803808 1 - by flanking markers 7488963 rat Bp369 Blood pressure QTL 369 17 0.001 628708 Zp4 67385 Cacnb2 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500;9685142 23814039;25380161 Bp310 (interacts with);Bp370 (interacts with) 17 67248685 83762100 1 - by flanking markers 17 69576957 89078870 1 - by flanking markers 7421621 SS.LEW-(D17Chm131-D17Chm93)/Ayd 17 65497359 82019219 1 - by flanking markers 17 59005649 77910000 1 - by flanking markers 7488966 rat Bp370 Blood pressure QTL 370 17 0.001 38706 D17Rat84 45485 D17Wox9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) decreased mean systemic arterial blood pressure Hypotension 7421500 23814039 Bp369 (interacts with) 17 23473207 63969577 1 - by flanking markers 17 29603712 65900518 1 - by flanking markers 7421623 SS.LEW-(D17Rat84-D17Chm17)/Ayd 17 21490950 62195822 1 - by flanking markers 17 23653184 57246843 1 - by flanking markers 7771603 rat Bp371 Blood pressure QTL 371 2 1.0E-5 7495817 rs106870553 7495821 rs64088007 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased mean systemic arterial blood pressure;decreased systemic arterial diastolic blood pressure;decreased systemic arterial systolic blood pressure 7495755 23861781 1303105 Dear Memor19 (maps to same region) 2 203270720 206602006 1 - by flanking markers 2 176635705 179892073 1 - by flanking markers 7771589 SS.SR-(D2Rat352-rs63922710)/Opaz 2 183864092 187196901 1 - by flanking markers 2 170201741 173290301 1 - by flanking markers 7771605 rat Memor19 Memory QTL 19 2 1.0E-5 7495817 rs106870553 7495821 rs64088007 exploratory behavior trait (VT:0010471) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) impaired spatial learning Memory Disorders;learning disability 7495755 23861781 1303105 Dear Bp371 (maps to same region) 2 203270720 206602006 1 - by flanking markers 2 176635705 179892073 1 - by flanking markers 7771589 SS.SR-(D2Rat352-rs63922710)/Opaz 2 183864092 187196901 1 - by flanking markers 2 170201741 173290301 1 - by flanking markers 7771612 rat Cm80 Cardiac mass QTL 80 1 8.4 34922 D1Rat43 35909 D1Rat74 41012 D1Rat287 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) decreased heart left ventricle weight;heart left ventricle hypertrophy hypertension 7771608 23901062 1 168015290 248763894 2 - by one flank and peak markers 1 153222955 227005733 2 - by one flank and peak markers 737926 1581618 F344/NCrl SHRSP/Bbb 1 144634295 241482368 1 - by flanking markers 1 149448574 221264292 2 - by one flank and peak markers 7794739 rat Bp372 Blood pressure QTL 372 5 0.0058 7777093 D5Mco58 7794805 D5Mco41 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 7495753 23757393 70987;1307814;1309582 Faf1;Zyg11b;Zyg11a Bp156 (sub_region);Bp373 (interacts with) 7794700 SS.LEW-(D5Mco39-D5Mco41)/Mco 5 122679716 130167412 1 - by flanking markers 5 117913688 125222967 1 - by flanking markers 7794743 rat Bp373 Blood pressure QTL 373 5 0.0058 7794807 D5Mco42 7794818 D5Mco47 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) decreased systemic arterial systolic blood pressure 7495753 23757393 1307610 Raver2 Bp157 (sub_region);Bp372 (interacts with) 7794704 SS.LEW-(D5Mco42-D5Mco47)/2Mco 5 116151740 120258073 1 - by flanking markers 5 112175546 116047089 1 - by flanking markers 7794784 rat Mcs31 Mammary carcinoma susceptibility QTL 31 9 2.98 33999 D9Mit5 36325 D9Rat1 41600 D9Rat110 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 628634 Prlh 9 89765913 119437586 1 - by flanking markers 9 75633467 110864247 1 - by flanking markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 9 90024661 119983851 1 - by flanking markers 9 77813894 111552878 1 - by flanking markers 7794788 rat Mcs32 Mammary carcinoma susceptibility QTL 32 1 2.61 35166 D1Rat33 36325 D9Rat1 37560 D1Rat155 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 2991;1308810 Anpep;Blm 1 123747670 275658314 2 - by one flank and peak markers 1 115946374 247103468 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 1 122614824 262664716 2 - by one flank and peak markers 1 115540693 238914717 2 - by one flank and peak markers 7794791 rat Mcs33 Mammary carcinoma susceptibility QTL 33 5 1.93 33680 D5Mit13 38916 D5Rat106 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 620293 Ece1 5 140429780 177180328 2 - by one flank and peak markers 5 138271925 173096209 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 5 136640731 173707219 2 - by one flank and peak markers 5 131345754 166875058 2 - by one flank and peak markers 7794793 rat Mcs34 Mammary carcinoma susceptibility QTL 34 18 1.54 40576 D18Rat127 40918 D18Rat80 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) increased mammary gland tumor incidence Experimental Mammary Neoplasms 7794780 23967281 3031 Smad2 18 64771076 83650204 2 - by one flank and peak markers 18 66439387 87265094 2 - by one flank and peak markers intercross 1582184 1582190 SR/JrHsd SS/JrHsd 8552782 rat Vie1 Viral induced encephalitis QTL 1 4 26.4 1626708 D4Kini1 42156 D4Arb25 7241149 D4Kini3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 621001 Calcr Bw143 (maps to same region);Bw144 (maps to same region);Vie4 (maps to same region);Vie5 (maps to same region) 4 31693512 148193854 1 - by flanking markers 4 31074957 81729616 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 31825560 83531021 1 - by flanking markers 4 34430484 82490359 1 - by flanking markers 8552791 rat Vie2 Viral induced encephalitis QTL 2 3 4.1 36584 D3Rat6 36759 D3Rat59 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 3 158307259 183740530 2 - by one flank and peak markers 3 147990566 171063335 2 - by one flank and peak markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 3 153412455 177699992 2 - by one flank and peak markers 3 145956084 169034231 2 - by one flank and peak markers 8552796 rat Vie3 Viral induced encephalitis QTL 3 6 2.6 37848 D6Rat100 40332 D6Rat152 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 6 110589216 156897508 2 - by one flank and peak markers 6 100709370 147636619 2 - by one flank and peak markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 6 101207574 147991367 2 - by one flank and peak markers 6 96833997 140994061 2 - by one flank and peak markers 8552801 rat Bw143 Body weight QTL 143 4 7.3 1626708 D4Kini1 42156 D4Arb25 7241149 D4Kini3 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) abnormal body weight Body Weight Changes 7240516 22761571 Bw144 (maps to same region);Vie1 (maps to same region);Vie4 (maps to same region);Vie5 (maps to same region) 4 31693512 148193854 1 - by flanking markers 4 31074957 81729616 1 - by flanking markers intercross;measurement method: 45 days old rats were infected in the whiskers area with 2X106 PFU of HSV-1 and change in body weight from the day of infection to 5 days post-infection (d0-d5)determined 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 31825560 83531021 1 - by flanking markers 4 34430484 82490359 1 - by flanking markers 8552803 rat Bw144 Body weight QTL 144 4 16.0 39704 D4Rat222 42156 D4Arb25 1626708 D4Kini1 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) abnormal body weight Body Weight Changes 7240516 22761571 Bw143 (maps to same region);Vie1 (maps to same region);Vie4 (maps to same region);Vie5 (maps to same region) 4 19564454 31693512 1 - by flanking markers 4 19044128 31074957 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 19618866 31825560 1 - by flanking markers 4 22710685 34430484 1 - by flanking markers 8552805 rat Bw145 Body weight QTL 145 10 2.2 38824 D10Rat78 36878 D10Rat219 35228 D10Rat29 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) abnormal body weight Body Weight Changes 7240516 22761571 10 42987979 80884595 1 - by flanking markers 10 43361250 81986757 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 10 43188659 81042642 1 - by flanking markers 10 41944526 78307017 1 - by flanking markers 8552807 rat Vie4 Viral induced encephalitis QTL 4 4 7.3 1626708 D4Kini1 10144 D4Mgh16 7241149 D4Kini3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 Bw143 (maps to same region);Bw144 (maps to same region);Vie1 (maps to same region);Vie5 (maps to same region) 4 61427664 148193854 1 - by flanking markers 4 61646915 81729616 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 61708341 83531021 1 - by flanking markers 4 62933508 82490359 1 - by flanking markers 8552809 rat Vie5 Viral induced encephalitis QTL 5 4 25.3 1626708 D4Kini1 42156 D4Arb25 7241149 D4Kini3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) brain inflammation Herpes Simplex Encephalitis 7240516 22761571 Bw143 (maps to same region);Bw144 (maps to same region);Vie1 (maps to same region);Vie4 (maps to same region) 4 31693512 148193854 1 - by flanking markers 4 31074957 81729616 1 - by flanking markers intercross 2307156 2307157 DA/ZtmKini PVG.1AV1/Kini 4 31825560 83531021 1 - by flanking markers 4 34430484 82490359 1 - by flanking markers 8552891 rat Epfw5 Epididymal fat weight QTL 5 1 4.4 38570 D1Rat240 11202 D1Wox28 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) decreased epididymal fat pad weight Weight Loss 8552892 24099777 1303323 Slc22a18 1 217580043 262580043 4 - by one flank marker only 1 198079308 243079308 4 - by one flank marker only intercross 629465 631577 SHR/NCrlCrlj SHR/Izm 1 210652654 255652654 4 - by one flank marker only 1 193113876 238113876 4 - by one flank marker only 8552900 rat Pigfal1 Plasma insulin-like growth factor 1 level QTL 1 1 7.4 14.5 37960 D1Rat196 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 1 36782523 81782523 5 - by peak with adj size 1 32584029 77584029 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 1 35854167 80854167 5 - by peak with adj size 1 34836858 79836858 5 - by peak with adj size 8552903 rat Pigfal2 Plasma insulin-like growth factor 1 level QTL 2 4 7.3 147.7 38776 D4Rat142 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 4 1 28376172 5 - by peak with adj size 4 1 27327405 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 1 28352196 5 - by peak with adj size 4 1 31934116 5 - by peak with adj size 8552906 rat Pigfal3 Plasma insulin-like growth factor 1 level QTL 3 4 41102 D4Rat151 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 4 7944365 52944365 5 - by peak with adj size 4 6913861 51913861 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 4 8052189 53052189 5 - by peak with adj size 4 10084089 55084089 5 - by peak with adj size 8552908 rat Pigfal4 Plasma insulin-like growth factor 1 level QTL 4 5 6.6 11.3 34168 D5Mgh22 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 5 138453703 177180328 5 - by peak with adj size 5 135084412 173096209 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 5 134712342 173707219 5 - by peak with adj size 5 128506074 166875058 5 - by peak with adj size 8552910 rat Pigfal5 Plasma insulin-like growth factor 1 level QTL 5 6 4.3 9.1 35911 D6Rat33 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 6 29146795 74146795 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 6 19417887 64417887 5 - by peak with adj size 8552912 rat Pigfal6 Plasma insulin-like growth factor 1 level QTL 6 12 5.0 9.1 61278 D12Arb5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 12 11147464 54450796 5 - by peak with adj size 12 6630245 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223630 52716770 5 - by peak with adj size 12 5564498 46669029 5 - by peak with adj size 8552918 rat Pigfal7 Plasma insulin-like growth factor 1 level QTL 7 12 34729 D12Mgh5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 12 11147460 54450796 5 - by peak with adj size 12 6630242 46782294 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 12 9223626 52716770 5 - by peak with adj size 12 5564495 46669029 5 - by peak with adj size 8552920 rat Pigfal8 Plasma insulin-like growth factor 1 level QTL 8 15 3.0 4.5 40358 D15Rat110 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 15 1 41712083 5 - by peak with adj size 15 1 36290302 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 15 1 37708474 5 - by peak with adj size 15 1 34723002 5 - by peak with adj size 8552928 rat Pigfal9 Plasma insulin-like growth factor 1 level QTL 9 17 9.0 15.4 34120 D17Mgh5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 17 28671746 73671746 5 - by peak with adj size 17 36604895 81604895 5 - by peak with adj size intercross 1354670 7401261 F344/IcoCrlf LOU/NimrOlaHsd 17 30975228 75975228 5 - by peak with adj size 17 28409147 73409147 5 - by peak with adj size 8552935 rat Pigfal10 Plasma insulin-like growth factor 1 level QTL 10 19 5.7 9.7 35959 D19Rat15 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) abnormal circulating insulin-like growth factor I level Insulin-Like Growth Factor I Deficiency;disease of metabolism 7794844 24028904 19 4307913 49307913 5 - by peak with adj size 19 1 3792